[{"hash":"712052476919120832","title":"Hypoxia-responsive transcription and development","description":"Dominant themes are transcriptional regulation (DNA-templated transcription, circadian control) and hypoxia/HIF-1alpha signaling, with immune/developmental and xenobiotic-response processes; together these suggest genes co-regulated under hypoxic or stress conditions that influence developmental pathways.","confidence":"Medium","size":29,"edges":199,"triangles":949,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":20},{"id":"GO:0060574","count":17},{"id":"GO:0061419","count":17},{"id":"GO:0009410","count":17},{"id":"GO:0021502","count":17}]},{"hash":"1841788758642676977","title":"Eye and neural development","description":"The top GO terms cluster around embryonic eye morphogenesis and camera-type eye development, along with cerebellum development, rhombomere 5 development, and motor neuron axon guidance, indicating a cohesive program of ocular and neural patterning and morphogenesis. While some terms touch broader development, the dominant theme is eye and nervous system construction during development. ","confidence":"High","size":29,"edges":321,"triangles":1831,"max_degree":28,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":15},{"id":"GO:0000122","count":13},{"id":"GO:0048048","count":13},{"id":"GO:0043010","count":12},{"id":"GO:0060441","count":12}]},{"hash":"1873696273771708224","title":"Developmental signaling and stress responses","description":"This cluster aggregates proteins linked to various developmental processes (lung mesenchyme development, Schwann cell development, tricuspid valve morphogenesis) and signaling/stress pathways (MAPK cascade, apoptotic process, response to toxic substance, vitamin D3 metabolism). The convergence of developmental terms with stress- and signaling-related GO terms suggests a theme of signaling that coordinates development and cellular stress responses.","confidence":"High","size":29,"edges":189,"triangles":533,"max_degree":23,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070640","count":29},{"id":"GO:0072709","count":29},{"id":"GO:0000196","count":29},{"id":"GO:0060484","count":29},{"id":"GO:0006915","count":29}]},{"hash":"2280367609307230083","title":"Immune Activation and Vascular/Lymphatic Morphogenesis","description":"The top GO terms cluster around immune signaling and activation (platelet activation, basophil activation, leukocyte tethering/rolling, Fc-gamma receptor signaling, NK cell chemotaxis regulation), with additional developmental morphogenesis terms for vessels/lymphatics and kidneys, suggesting an immune-vascular context. Confidence: Medium","confidence":"","size":29,"edges":404,"triangles":3600,"max_degree":28,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":29},{"id":"GO:0072177","count":29},{"id":"GO:0072287","count":29},{"id":"GO:0036303","count":29},{"id":"GO:0090403","count":29}]},{"hash":"761255409796115872","title":"Neuronal development and axon guidance","description":"This cluster shows strong enrichment for neural development and connectivity processes: CNS neurogenesis and axonogenesis, retinal ganglion cell axon guidance, ROBO/roundabout signaling, synapse assembly, and myelination, along with corpus callosum development and CNS projection neuron wiring. The presence of cell surface receptor tyrosine kinase signaling supports growth and guidance cues, with angiogenesis accompanying neural development. Together these terms point to neural development and axon pathfinding in the CNS, justifying this label.","confidence":"High","size":29,"edges":230,"triangles":819,"max_degree":25,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007169","count":13},{"id":"GO:0071372","count":13},{"id":"GO:0051965","count":13},{"id":"GO:0031290","count":13},{"id":"GO:0035385","count":13}]},{"hash":"841469790707987149","title":"Chromatin Remodeling and Transcription Regulation","description":"The top GO terms cluster around chromatin assembly, heterochromatin formation, and transcription regulation (e.g., DNA replication-dependent chromatin assembly, rDNA heterochromatin, transcription initiation-coupled remodeling), plus centromere-related chromatin maintenance and sister chromatid cohesion. This points to a cohesive module of proteins modulating chromatin structure to control RNA polymerase II activity and genome stability, with a few immune-related terms likely reflecting broader regulatory roles.","confidence":"High","size":29,"edges":383,"triangles":3082,"max_degree":28,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000122","count":23},{"id":"GO:0051290","count":22},{"id":"GO:0071169","count":21},{"id":"GO:0006335","count":19},{"id":"GO:0000183","count":19}]},{"hash":"864512835856555584","title":"Unknown","description":"The top terms cover a broad mix of developmental processes (myelination, spleen and cartilage development, cortex migration, gonad development) and core nuclear functions (DNA replication, recombination, transcription regulation) with no clear shared function tying them together. There are no observed edges or interactions, suggesting no cohesive pathway or theme. Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0022011","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0006310","count":3},{"id":"GO:0075015","count":3}]},{"hash":"238704166268113043","title":"RNA metabolism and translation with antiviral responses","description":"Dominant GO terms are translation and RNA processing (translation, translation termination, rRNA catabolic process, miRNA processing) together with antiviral and toxin/stress responses (response to virus/toxic substance/antibiotic, negative regulation of viral genome replication). This pattern points to a cluster of proteins involved in RNA metabolism and protein synthesis, potentially linked to host defense and stress responses, with a few neural development annotations that may reflect multifunctionality. ","confidence":"Medium","size":29,"edges":404,"triangles":3601,"max_degree":28,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":18},{"id":"GO:0009636","count":7},{"id":"GO:0045071","count":7},{"id":"GO:0009615","count":6},{"id":"GO:0006415","count":5}]},{"hash":"1068848996057552981","title":"Neuronal development and synapse formation","description":"These proteins cluster around neural development and synaptic maturation: axonogenesis, dendritic spine morphogenesis, excitatory postsynaptic potential, and synapse assembly are central, along with corpus callosum and Schwann cell development, indicating broad CNS/PNS maturation and connectivity. Regulatory processes like DNA-templated transcription and mRNA processing support neural gene expression programs. The abscisic acid term is likely an annotation anomaly, but does not override the neural theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0009738","count":4},{"id":"GO:0014044","count":4},{"id":"GO:0007409","count":4},{"id":"GO:0048320","count":4}]},{"hash":"1341569301313047028","title":"Immune signaling and developmental processes","description":"This cluster shows GO terms centered on immune signaling (innate immune response, mast cell degranulation, neutrophil clearance, STAT phosphorylation) and broad development signals (nervous system development, myoblast fusion, lung mesenchyme development, VEGF-PDGF\u2013driven proliferation). The mix suggests proteins participating in signaling cascades that influence both immune responses and tissue development rather than a single specific function. The connectivity is low (single edge, no triangles), consistent with a diverse, multifunctional set rather than a tight functional module.","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042523","count":11},{"id":"GO:0007399","count":11},{"id":"GO:0097350","count":11},{"id":"GO:0007520","count":11},{"id":"GO:0051092","count":10}]},{"hash":"510263989550974882","title":"Nucleocytoplasmic transport and cell cycle","description":"This cluster centers on nuclear transport and chromosome management: terms like ribosomal protein import into nucleus, NLS-bearing protein import, mRNA transport, and nuclear pore complex assembly anchor a nucleocytoplasmic trafficking theme, while mitotic sister chromatid separation and meiotic cohesion point to cell-cycle processes. The presence of GTPase activity regulation aligns with Ran-dependent transport, supporting a cohesive functional grouping around nucleus-cytoplasm trafficking and chromosome segregation during cell division.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0097011","count":6},{"id":"GO:0006610","count":6},{"id":"GO:0051028","count":6}]},{"hash":"2054583874304849547","title":"Axon Guidance and Neural Crest Migration","description":"The cluster is dominated by GO terms tied to neuronal development and connectivity\u2014axonal fasciculation, branchiomotor neuron axon guidance, trigeminal nerve organization, neural crest cell migration, semaphorin-plexin signaling in axon guidance, cell adhesion, and synapse assembly\u2014suggesting roles in axon pathfinding and neural structure formation. A single term on complement activation appears as an outlier but does not change the overall neural-development theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007413","count":12},{"id":"GO:0014068","count":12},{"id":"GO:0021785","count":11},{"id":"GO:0021637","count":11},{"id":"GO:0036486","count":11}]},{"hash":"1772639554102005185","title":"Dopaminergic neural signaling and sensory perception","description":"This cluster is dominated by neural and sensory processes: dopaminergic synaptic transmission, visual perception and learning, and sensory perception of pain, along with cocaine-induced behavioral responses. Signaling regulation via ERK cascades and GTPases further supports a theme of neural communication and behavioral modulation. A couple of terms (heart development, prostaglandin response) are less central but may reflect shared signaling pathways. ","confidence":"High","size":29,"edges":375,"triangles":2912,"max_degree":28,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":13},{"id":"GO:0007507","count":13},{"id":"GO:0071380","count":12},{"id":"GO:0008542","count":12},{"id":"GO:0007601","count":12}]},{"hash":"1677946494396571911","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000447","count":7},{"id":"GO:0000480","count":7},{"id":"GO:0000472","count":7},{"id":"GO:0048265","count":7},{"id":"GO:0030433","count":6}]},{"hash":"85914784016471185","title":"Embryonic Development and Morphogenesis","description":"The proteins cluster around broad developmental programs, especially placental/trophoblast differentiation, endocrine system development, heart/endocardial EMT, cartilage morphogenesis, and left-right patterning, plus transcriptional regulation and ECM remodeling. While a term like complement activation is less directly tied, the dominant theme is embryonic development and tissue morphogenesis across multiple lineages.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0003323","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0060806","count":5}]},{"hash":"1565424678449962205","title":"Dopaminergic Synaptic Signaling and Perception","description":"This cluster centers on neural signaling and sensory processing, with strong enrichment for dopaminergic synaptic transmission, cocaine response, visual and pain perception, and ERK signaling with protein phosphorylation, suggesting a cohesive theme of neural signaling and sensory processing.","confidence":"High","size":29,"edges":249,"triangles":814,"max_degree":23,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":26},{"id":"GO:0008542","count":25},{"id":"GO:0007507","count":25},{"id":"GO:0007601","count":25},{"id":"GO:0071380","count":25}]},{"hash":"943300288009272293","title":"Wnt-regulated cell proliferation and migration during development","description":"The cluster centers on regulation of cell cycle and proliferation (mitotic cytokinesis, cell cycle), cell migration, and modulation of canonical Wnt signaling, with links to embryonic limb morphogenesis and development. This suggests a cohesive developmental program where proliferation and movement are fine-tuned by Wnt pathway activity.","confidence":"High","size":29,"edges":296,"triangles":1546,"max_degree":28,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0016477","count":15},{"id":"GO:0043065","count":15},{"id":"GO:0090090","count":15},{"id":"GO:0015991","count":15},{"id":"GO:0008285","count":15}]},{"hash":"2220903479230052854","title":"Neural development and cell division with vesicle trafficking","description":"The terms cluster around brain development and cell division, with strong signals for Wnt signaling and mitotic spindle assembly, plus vesicle trafficking activities (ER\u2013Golgi transport and COPII budding). A unifying theme is the coordination of developmental signaling with cell cycle processes and intracellular transport, suggesting a neural development context where proliferation is coupled with vesicle trafficking.","confidence":"Medium","size":29,"edges":46,"triangles":13,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0007420","count":7},{"id":"GO:0032258","count":7},{"id":"GO:0033138","count":7},{"id":"GO:0035900","count":6}]},{"hash":"246034145842427718","title":"Coagulation, complement activation, and fibrinolysis","description":"The top GO terms are dominated by blood coagulation, complement activation (classical and lectin pathways), and fibrinolysis/plasminogen activation, with supportive terms for collagen catabolic remodeling and smooth muscle migration. This suggests a functional cluster centered on the coagulation cascade, its regulation, and clot remodeling, with a consistent emphasis on complement involvement.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0006958","count":9},{"id":"GO:0007596","count":9},{"id":"GO:0030574","count":9},{"id":"GO:0001867","count":8},{"id":"GO:0000122","count":8}]},{"hash":"1303642271828576925","title":"Neuronal signaling and spine morphogenesis","description":"The cluster\u2019s top terms strongly point to neuronal function and synaptic plasticity, including glutamatergic synaptic transmission, dendritic spine morphogenesis, and sensory perception of sound, which together reflect neural connectivity and plasticity. Regulation of Rho signaling supports cytoskeletal changes underlying spine formation, while proteolysis and protein catabolic processes relate to turnover of synaptic proteins. Although apoptosis and xenobiotic response appear, the dominant theme is neuronal signaling and spine development.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006508","count":5},{"id":"GO:0035023","count":4},{"id":"GO:0042493","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0006355","count":3}]},{"hash":"549683890419946710","title":"Diverse Transmembrane Transport","description":"The top GO terms point to transport across membranes for a wide range of substrates (neurotransmitter vesicle loading; xenobiotics; sugars like galactose and fucose; vitamins; ions such as sodium and phosphate; and other small molecules). This suggests the cluster largely comprises membrane transporters handling multiple substrates rather than a single specific function, justifying a label of diverse transmembrane transport.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":4},{"id":"GO:0006855","count":4},{"id":"GO:0015757","count":4},{"id":"GO:1900754","count":4},{"id":"GO:0015739","count":4}]},{"hash":"1413443629694386998","title":"Epidermal Differentiation and Cell-adhesion","description":"This cluster features keratinocyte differentiation, Notch signaling in skin, and cell\u2013cell adhesion terms (homophilic/heterophilic), all indicating epidermal development and barrier formation. Additional terms about hair orientation and TNF response support a skin-relevant adhesive signaling program, with oxidant detoxification suggesting epidermal redox regulation.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0055114","count":14},{"id":"GO:0098869","count":10},{"id":"GO:0051965","count":8},{"id":"GO:0010042","count":7},{"id":"GO:0007220","count":7}]},{"hash":"2215004936471551197","title":"Hexosamine metabolism and pentose phosphate pathway","description":"Most GO terms indicate amino-sugar and carbohydrate metabolism, notably glucosamine/N-acetylglucosamine catabolic and UDP-N-acetylglucosamine biosynthetic processes, together with oxidative pentose phosphate shunt activity. This points to a shared role in hexosamine turnover and PPP-driven NADPH production. A couple of terms (menaquinone biosynthesis, dephosphorylation) are less aligned but do not dominate the set.","confidence":"High","size":29,"edges":2,"triangles":0,"max_degree":2,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0019509","count":4},{"id":"GO:0005975","count":4},{"id":"GO:0006043","count":4},{"id":"GO:0019262","count":4},{"id":"GO:0006048","count":4}]},{"hash":"873137364738045009","title":"DNA Damage Response and Apoptosis","description":"Based on the top GO terms, the cluster is enriched for apoptotic processes and DNA repair/ catabolic activities (base-excision repair, DNA catabolic process), indicating a shared role in DNA damage response and programmed cell death. Other terms like cellular response to cAMP and translation regulation suggest broader stress signaling, but the strongest signal is DNA damage response coupled with apoptosis, justifying this label.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0006308","count":4},{"id":"GO:0071320","count":4},{"id":"GO:0017148","count":3},{"id":"GO:0014912","count":3}]},{"hash":"1283674350053303247","title":"Rho GTPase\u2013driven cytoskeletal remodeling and polarity","description":"Based on the GO terms, the cluster is enriched for regulation and activation of Rho/small GTPases, GTPase signaling, actin cytoskeleton organization, and processes like filopodium assembly and cell polarity, pointing to a cohesive role in cytoskeletal dynamics and cell shape control. Some terms related to neuronal signaling appear but do not outweigh the dominant cytoskeletal theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":8},{"id":"GO:0090630","count":8},{"id":"GO:0071963","count":7},{"id":"GO:0007205","count":7},{"id":"GO:0007605","count":7}]},{"hash":"1280481804243965036","title":"Unknown","description":"Top terms are spread across actin organization, translation, angiogenesis, stem cell differentiation, receptor trafficking, and synaptic regulation, with some obsolete GO terms. This broad mix provides no single cohesive function to bind the cluster, and the presence of obsolete terms suggests annotation noise rather than a shared biological theme.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070584","count":3},{"id":"GO:0051764","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0006744","count":2}]},{"hash":"1211513707498305470","title":"Immune Response to Biotic Stimuli","description":"The majority of top GO terms point to host defense and immune signaling (host-mediated suppression of symbiont invasion; responses to interferon-alpha/beta; general response to biotic stimulus). Some terms about endosomal transport, insulin response, and bone/neuromuscular development may reflect broader cellular processes linked to signaling or incidental associations, but they do not undermine the immune-focused theme. Overall, the cluster centers on immune/biotic-response functions.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046597","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0035456","count":3},{"id":"GO:0035455","count":3},{"id":"GO:0044381","count":3}]},{"hash":"1740899502385420712","title":"Heart development and conduction system signaling","description":"The terms point to cardiac development and patterning (right atrium morphogenesis, venous endothelial differentiation) with specific emphasis on the conduction system (regulation of SA node cell action potential) and key signaling pathways (Notch, Wnt) plus calcium handling (calcium release into cytosol). Negative regulation of serine/threonine kinase activity fits general signaling control in this context, suggesting a cohesive role in heart formation and electrical function.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007205","count":14},{"id":"GO:0003270","count":13},{"id":"GO:0071901","count":13},{"id":"GO:0060843","count":13},{"id":"GO:0003213","count":13}]},{"hash":"1196400696982447922","title":"Fatty acid oxidation and lipid metabolism","description":"The top GO terms point to lipid-related processes: carnitine metabolic process, fatty acid beta-oxidation, and epoxygenase P450 pathways, suggesting a cluster enriched for lipid metabolism and energy production. A heart development term hints at tissue-specific metabolic roles, which can accompany lipid utilization in cardiac contexts. Some items (translation, DNA recombination, symbiont entry) are broader cellular processes and less tied to lipid metabolism, but the dominant signal is lipid catabolism and related signaling. Overall, a lipid metabolism\u2013driven cluster is most representative.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019254","count":3},{"id":"GO:0033540","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0006310","count":2},{"id":"GO:0046718","count":2}]},{"hash":"1518859763059370847","title":"Embryonic morphogenesis across tissues","description":"The GO terms are dominated by embryonic development and morphogenesis across diverse tissues (e.g., EMT in heart cushion formation, cartilage morphogenesis, left-right patterning, mesoderm development, hair follicle morphogenesis, endocrine system development), suggesting a broad developmental program rather than a tissue-specific process.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":29},{"id":"GO:0060536","count":29},{"id":"GO:0060972","count":29},{"id":"GO:0003323","count":29},{"id":"GO:0060021","count":29}]},{"hash":"174012629308395205","title":"Mitotic Cell Cycle and Spindle Assembly","description":"The top GO terms are dominated by mitosis-related processes (mitotic cell cycle, mitotic spindle assembly) and by protein interaction and signaling activities (homooligomerization/heterotrimerization, autophosphorylation, and kinase activity regulation). This points to a cluster of proteins involved in the cell division machinery and phosphorylation-driven control, with some related terms like muscle development and hypoxia response that can intersect with cell cycle processes. Therefore, the label captures the core theme of mitotic apparatus function and regulation.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051260","count":9},{"id":"GO:0070208","count":8},{"id":"GO:0000278","count":8},{"id":"GO:0048741","count":7},{"id":"GO:0043547","count":7}]},{"hash":"847527261138179274","title":"Endocytic Regulation of Receptor Signaling","description":"The top terms point to GPCR internalization and clathrin-dependent endocytosis, accompanied by ubiquitination and signaling pathways (insulin/IGF signaling), suggesting a cluster centered on endocytic trafficking that modulates receptor-mediated signaling and metabolic responses. Peripheral development terms may reflect broader annotation rather than core function.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0002031","count":6},{"id":"GO:0072583","count":6},{"id":"GO:2001275","count":5},{"id":"GO:0048009","count":5},{"id":"GO:0046676","count":5}]},{"hash":"710231265514832047","title":"Cell cycle and angiogenesis regulation","description":"The top GO terms are dominated by mitotic processes (cell division, mitotic cell cycle, G1/S transition, re-entry into the mitotic cell cycle) and angiogenesis (angiogenesis and positive regulation of angiogenesis), indicating a core theme of cell proliferation and blood vessel formation. Other terms like insulin receptor signaling and retinoic acid response suggest supportive growth signaling and transcriptional regulation, but the strongest signal centers on proliferation and angiogenic control.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0000278","count":2}]},{"hash":"1534911269871446356","title":"Cell adhesion in neural development and immune signaling","description":"The top GO terms include both cell\u2013cell adhesion (homophilic/heterophilic) and actin cytoskeleton regulation tied to adhesion, along with nervous system development (axon guidance, fasciculation). At the same time, immune functions appear (complement activation, NK/T cell regulation, B cell activation). This suggests a theme of adhesion-mediated signaling and cytoskeletal remodeling that influences both neural development and immune cell interactions, rather than a single narrow pathway.","confidence":"Medium","size":29,"edges":37,"triangles":2,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":14},{"id":"GO:0007157","count":14},{"id":"GO:0002859","count":13},{"id":"GO:0007399","count":13},{"id":"GO:0090138","count":13}]},{"hash":"1205275077201719314","title":"GPCR signaling in cardiovascular and immune regulation","description":"These proteins show strong ties to G protein-coupled receptor signaling and its downstream pathways (GPCR pathway regulation, adenylate cyclase-inhibiting serotonin signaling), along with vascular smooth muscle contraction and heart-rate-related regulation. Additional terms involve dendritic cell chemotaxis and dopamine secretion regulation, indicating broader GPCR-centered signaling impacting cardiovascular, neural, and immune functions. ","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":29},{"id":"GO:0031649","count":29},{"id":"GO:2000420","count":29},{"id":"GO:0001997","count":29},{"id":"GO:0045745","count":29}]},{"hash":"650404785330275292","title":"Diverse metabolite biosynthesis","description":"This cluster centers on biosynthesis of a wide range of specialized metabolites (antibiotics, tropane alkaloids, retinoids, phylloquinone, mycolic acids, poly-hydroxybutyrate) and related small-molecule pathways, with some catabolic terms also present; the common thread is production of diverse metabolites rather than a single pathway, so \u201cDiverse metabolite biosynthesis\u201d seems appropriate.","confidence":"Medium","size":29,"edges":226,"triangles":717,"max_degree":26,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":19},{"id":"GO:0042619","count":14},{"id":"GO:0006729","count":13},{"id":"GO:0042376","count":13},{"id":"GO:0071768","count":13}]},{"hash":"823672371702277181","title":"Chromosome segregation and septin dynamics","description":"Top GO terms center on sister chromatid cohesion, biorientation, spindle orientation checkpoints, and septin ring organization, pointing to chromosome segregation during cell division and associated cytoskeletal/septin dynamics. The link to chromosome localization and GTPase regulation supports a coordinated control module for segregation and cytokinesis.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051754","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0031578","count":3},{"id":"GO:0032186","count":3},{"id":"GO:0031134","count":3}]},{"hash":"312683404671603635","title":"Ubiquitin-Proteasome Regulation of TNF/NF-\u03baB Signaling","description":"The top GO terms cluster around ubiquitination and ubiquitin-dependent protein degradation (including ubiquitin-dependent proteolysis, polyubiquitination, and autoubiquitination) and ERAD, along with regulatory roles in apoptosis and TNF-mediated signaling and NF-\u03baB pathway components. This suggests a functional grouping of proteins involved in tagging substrates for degradation and modulating TNF/NF-\u03baB signaling cascades, rather than a single structural or metabolic activity. Hence, a label focused on ubiquitin-mediated regulation linked to TNF/NF-\u03baB signaling best captures the shared theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0016567","count":8},{"id":"GO:0051865","count":8},{"id":"GO:0000209","count":7},{"id":"GO:0030433","count":7}]},{"hash":"1444459316812125255","title":"GPCR-Mediated Heart and Vascular Regulation","description":"The cluster is enriched for GO terms tied to G protein-coupled receptor signaling, including positive regulation of GPCR pathways, heart contraction regulation, vascular smooth muscle contraction, and dopaminergic/serotonergic signaling. Together these terms point to proteins involved in GPCR-triggered signaling that modulates cardiac function and vascular tone, with related immune/motility processes (e.g., dendritic cell chemotaxis, dopamine secretion) that fit a cohesive GPCR-centered cardiovascular regulatory theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":28},{"id":"GO:0031649","count":28},{"id":"GO:2000420","count":28},{"id":"GO:0001997","count":28},{"id":"GO:0045745","count":28}]},{"hash":"1756164782752875633","title":"Nuclear DNA replication and RNA processing","description":"The top GO terms point to core nuclear processes: DNA replication and cell cycle progression, PARylation, plus extensive RNA metabolism including mRNA export, spliceosome-mediated splicing, and regulation of translation initiation. This suggests a cohesive cluster centered on nucleic acid synthesis/duplication and subsequent gene expression control at the RNA level.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007049","count":4},{"id":"GO:0070212","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0006406","count":2},{"id":"GO:0045292","count":2}]},{"hash":"1496956959499690320","title":"mRNA deadenylation and decay","description":"The terms point to mRNA tail shortening, deadenylation-dependent decay and decapping, plus exonucleolytic RNA processing and P-body assembly, with additional hints of post-transcriptional regulation. This pattern suggests a cohesive cluster centered on mRNA turnover and post-transcriptional control.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000289","count":5},{"id":"GO:0045944","count":4},{"id":"GO:0000288","count":4},{"id":"GO:0000290","count":4},{"id":"GO:0090503","count":3}]},{"hash":"1597466699868269956","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000447","count":5},{"id":"GO:0000480","count":4},{"id":"GO:0000472","count":4},{"id":"GO:0003323","count":3},{"id":"GO:0060707","count":3}]},{"hash":"1466820771135159840","title":"Spliceosome-Associated RNA Processing and Deubiquitinases","description":"The cluster is dominated by GO terms for mRNA processing and spliceosomal complex assembly, pointing to RNA splicing activity. The presence of multiple deubiquitination terms across several ubiquitin linkages (K29, K11, K48, K6) suggests regulation of RNA processing or spliceosome components by ubiquitin signaling. Other terms (endosome-to-Golgi transport, NFAT signaling) are present but less central, so the overall theme centers on RNA processing modulated by deubiquitination.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":3},{"id":"GO:0000245","count":3},{"id":"GO:0035523","count":2},{"id":"GO:2000780","count":2},{"id":"GO:1901315","count":2}]},{"hash":"1231393198143210125","title":"Vertebrate embryonic development and sensory organogenesis","description":"The top GO terms cluster around vertebrate development across multiple tissues, notably neural and sensory systems (midbrain development, visual perception, inner ear development, glial differentiation), plus early embryogenesis (primitive streak formation) and organogenesis (roof of mouth, pituitary, uterine development, outflow tract morphogenesis), suggesting a group of transcriptional regulators shaping developmental programs. This aligns to a coherent theme of embryonic tissue specification and neural/sensory organ formation.","confidence":"High","size":28,"edges":3,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":17},{"id":"GO:0030901","count":15},{"id":"GO:0060021","count":12},{"id":"GO:0060065","count":12},{"id":"GO:0021983","count":12}]},{"hash":"1525497915823474044","title":"Neural crest\u2013driven craniofacial and nervous system development","description":"The terms cluster around neural crest derivatives and nervous system formation (neural crest cell migration, peripheral nervous system neuron development, motor neuron axon guidance) with supporting craniofacial/ear development terms, indicating a developmental program centered on neural crest\u2013mediated morphogenesis.","confidence":"High","size":28,"edges":15,"triangles":0,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0048839","count":12},{"id":"GO:0006366","count":11},{"id":"GO:0090009","count":11},{"id":"GO:0090190","count":10}]},{"hash":"2285775725433248278","title":"Cerebellar development and neural signaling","description":"The cluster is enriched for GO terms tied to cerebellar development, including cerebellar cortex formation and Bergmann glial differentiation, plus regulation of axon regeneration, which together point to cerebellar neurodevelopment and neural connectivity. While terms like insulin receptor signaling and T cell receptor signaling suggest broader signaling roles, the strongest and most recurrent themes center on cerebellar neurodevelopment. ","confidence":"Medium","size":28,"edges":363,"triangles":2918,"max_degree":27,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034501","count":22},{"id":"GO:0048679","count":22},{"id":"GO:0060020","count":22},{"id":"GO:0021697","count":22},{"id":"GO:0045736","count":22}]},{"hash":"506839529955052759","title":"Developmental signaling and morphogenesis","description":"This cluster is enriched for developmental and morphogenesis-related GO terms (lung-associated mesenchyme development, Schwann cell development, tricuspid valve morphogenesis) and is accompanied by signaling and stress-related terms (MAPK cascade, apoptotic process, response to toxic substance). While some terms like vitamin D3 metabolism and ABA signaling are broader or cross-kingdom, the overall theme centers on developmental signaling and tissue shaping with associated cellular responses. ","confidence":"High","size":28,"edges":334,"triangles":2320,"max_degree":27,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070640","count":28},{"id":"GO:0072709","count":28},{"id":"GO:0000196","count":28},{"id":"GO:0060484","count":28},{"id":"GO:0006915","count":28}]},{"hash":"1569515068263763393","title":"Motor neuron axon guidance and migration","description":"The top GO terms cluster around neuronal development, especially lateral motor column neuron migration, peripheral nervous system axonogenesis, motor neuron axon guidance, and cell\u2013matrix adhesion, which together point to motor neuron pathfinding and migration. Some terms like platelet aggregation and certain metabolic processes are less central, but the dominant signal supports a motor neuron development/axon guidance theme.","confidence":"High","size":28,"edges":367,"triangles":3012,"max_degree":27,"top_function":"wound healing","top_go_terms":[{"id":"GO:0097477","count":12},{"id":"GO:0070527","count":12},{"id":"GO:0048936","count":10},{"id":"GO:0007160","count":10},{"id":"GO:0008045","count":10}]},{"hash":"426086820392760008","title":"Neurodevelopmental signaling","description":"The cluster is dominated by GO terms related to nervous system development, including hippocampus development and axonogenesis, with supporting signals in dopamine response and MAPK/JNK pathways. A few immune-related terms appear but likely reflect shared signaling components rather than a primary immune function. Overall, the core theme is neural development and associated signaling, justifying a neurodevelopmental signaling label.","confidence":"High","size":28,"edges":121,"triangles":165,"max_degree":22,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050771","count":28},{"id":"GO:0043366","count":28},{"id":"GO:0021766","count":28},{"id":"GO:0007399","count":28},{"id":"GO:0033138","count":28}]},{"hash":"1540866846359727433","title":"Membrane trafficking and exocytosis","description":"The cluster is dominated by vesicle docking and exocytosis-related terms (e.g., vesicle docking involved in exocytosis; melanosome transport; positive regulation of protein localization to the plasma membrane), pointing to a core theme of membrane targeting and secretion. Additional terms related to wound healing and cell proliferation fit with cell migration and tissue remodeling, while some other terms may reflect context-dependent responses; overall, the shared function appears to be vesicle trafficking to the plasma membrane and secretion.","confidence":"High","size":28,"edges":212,"triangles":799,"max_degree":26,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903078","count":28},{"id":"GO:0042832","count":28},{"id":"GO:0008283","count":28},{"id":"GO:1903395","count":28},{"id":"GO:0006904","count":28}]},{"hash":"216787840089554266","title":"mRNA maturation and splicing regulation","description":"These proteins cluster around post-transcriptional RNA processing: spliceosome-mediated regulation of mRNA splicing (including alternative splicing), mRNA export from the nucleus, mRNA stability control, poly(A) tail regulation, and related mRNA modification and translation reinitiation steps. The shared functions point to a cohesive group dedicated to RNA maturation and regulation rather than transcriptional control alone.","confidence":"High","size":28,"edges":212,"triangles":612,"max_degree":24,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":19},{"id":"GO:0031047","count":18},{"id":"GO:0048026","count":18},{"id":"GO:0048025","count":18},{"id":"GO:0006406","count":17}]},{"hash":"390508204525374532","title":"Cardiovascular and musculoskeletal development","description":"These proteins cluster around developmental processes spanning heart development, angiogenesis, muscle formation (myoblast fusion), and bone maturation (ossification), as well as cardiac electrophysiology (SA node action potentials) and mechanotransduction. The convergence of these GO terms suggests a coordinated program guiding heart, vessel, muscle, and bone development, with supporting signaling (NF-kappaB) and membrane/trafficking processes that facilitate these changes.","confidence":"High","size":28,"edges":10,"triangles":2,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":7},{"id":"GO:0001525","count":6},{"id":"GO:0043123","count":6},{"id":"GO:0071260","count":6},{"id":"GO:0098907","count":5}]},{"hash":"717673579722722445","title":"Unknown","description":"The top GO terms span redox/metabolic processes (oxidation-reduction, redox homeostasis, thiamine and tetrahydrofolate metabolism) and also RNA processing and broad development (spliceosome-mediated splicing, histone demethylation, neural precursor proliferation, erythrocyte differentiation, pituitary development). There is no clear single functional theme linking these terms, suggesting a heterogeneous set of functions or annotation noise among the proteins. ","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":12},{"id":"GO:0045454","count":11},{"id":"GO:0071320","count":9},{"id":"GO:0009228","count":9},{"id":"GO:0046653","count":9}]},{"hash":"162552809113679365","title":"Ribosome Biogenesis and Translation Machinery","description":"Proteins in this cluster are enriched for translation and ribosome biogenesis, including cytoplasmic translation and ribosomal large subunit export from nucleus, indicating a core role in ribosome assembly and protein synthesis. The presence of cell cycle and mitotic cohesion terms suggests these processes may be coordinated with cell division, but the strongest signal centers on ribosome production and translation.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0042254","count":6},{"id":"GO:0051301","count":5},{"id":"GO:0007064","count":5},{"id":"GO:0002181","count":4}]},{"hash":"2256624079010668531","title":"Glycosylation and neuronal signaling","description":"The cluster centers on protein glycosylation processes (N-linked glycosylation, N-glycan processing) and synaptic functions (excitatory postsynaptic potential, synaptic vesicle endocytosis), with a parallel signaling component from tyrosine phosphorylation. This combination suggests a theme around glycosylation-modulated neuronal signaling and synaptic machinery.","confidence":"Medium","size":28,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050731","count":3},{"id":"GO:0006491","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0042403","count":2}]},{"hash":"671682881222368147","title":"Developmental Regulation and Organ Development","description":"The top GO terms are largely about developmental processes (skeletal muscle fiber development, lung development, lymphangiogenesis, and regulation of EMT) plus regulation of transcription and chromatin modification, suggesting a theme centered on developmental biology and gene expression control. There are a few terms that seem out of place (lipid A biosynthetic process, behavioral fear response), which may reflect annotation noise or broader functional overlap. The absence of edges indicates these proteins are not tightly connected genomically, aligning with a broad, multi-function developmental/regulatory cluster rather than a single cohesive pathway.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0048741","count":4},{"id":"GO:0060013","count":3},{"id":"GO:0010719","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0030324","count":3}]},{"hash":"1675170650719821332","title":"Ubiquitin-dependent proteolysis in muscle development","description":"The cluster is dominated by GO terms tied to ubiquitin biology and protein catabolism (K48- and K11-linked deubiquitination, monoubiquitinated protein deubiquitination, and ubiquitin-dependent proteolysis), indicating proteins involved in the ubiquitin-proteasome system. The presence of heart development and fast/slow muscle fiber transition terms suggests a muscle-related context, aligning the label with ubiquitin-mediated proteolysis in muscle development. Some terms (like social behavior) are unrelated noise but do not override the predominant ubiquitin-centric signal.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071108","count":6},{"id":"GO:0006511","count":6},{"id":"GO:1903070","count":5},{"id":"GO:0035871","count":5},{"id":"GO:0035176","count":4}]},{"hash":"1146792383425516551","title":"Bacterial central metabolism and biosynthetic pathways","description":"This cluster combines core energy metabolism (glycolysis, TCA cycle, beta-oxidation) with diverse bacterial biosynthetic/catabolic routes, including menaquinone and phylloquinone biosynthesis, amino acid catabolism, and even antibiotic biosynthesis, along with cell wall organization. The common thread appears to be broad bacterial metabolism and biosynthesis linked to central carbon flux, rather than a single, narrow function.","confidence":"Medium","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":13},{"id":"GO:0006096","count":10},{"id":"GO:0017000","count":10},{"id":"GO:0006635","count":6},{"id":"GO:0010124","count":6}]},{"hash":"1421172678264061707","title":"Transcriptional regulation and chromatin remodeling","description":"Based on GO terms such as negative regulation of transcription by RNA polymerase II, DNA-templated transcription, chromatin remodeling and histone deacetylation, the cluster appears enriched for regulators of gene expression through chromatin state modification. Some terms about apoptosis and differentiation are present, suggesting downstream effects, but the shared theme centers on transcriptional control and chromatin dynamics.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0006351","count":7},{"id":"GO:0043046","count":7},{"id":"GO:0043044","count":7},{"id":"GO:0016575","count":6}]},{"hash":"972417693417921850","title":"Cytoskeletal regulation in epithelial and endothelial cells","description":"The cluster centers on cytoskeletal dynamics such as stress fiber assembly and Rac/Rho signaling, plus processes like endothelial lumen formation and brush border assembly, which reflect cytoskeleton-driven remodeling in epithelial and vascular contexts.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051497","count":6},{"id":"GO:0006915","count":5},{"id":"GO:0097498","count":5},{"id":"GO:0035021","count":5},{"id":"GO:0035024","count":5}]},{"hash":"364283056364391808","title":"Embryonic Morphogenesis and Chromatin Regulation","description":"Top GO terms indicate strong involvement in developmental morphogenesis (uterus morphogenesis, somite axis specification, blastocyst formation, neural tube closure) and reproductive regulation (estradiol secretion). The accompanying chromatin-related terms (histone demethylation, heterochromatin regulation, ncRNA transcription) and ribosome biogenesis suggest coordinated control of gene expression during development. This supports a coherent theme of embryogenesis with chromatin remodeling and transcriptional regulation.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0061038","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0034720","count":3},{"id":"GO:1901726","count":3},{"id":"GO:0032525","count":3}]},{"hash":"53656924859059334","title":"Craniofacial and vascular development with coagulation","description":"The GO terms center on craniofacial development (roof of mouth), multicellular growth, angiogenesis, and coagulation-related processes (fibrinolysis, plasminogen activation), plus EMT in heart development and biomineral tissue formation. Together these indicate a cluster of proteins involved in developmental formation of craniofacial structures and vasculature with remodeling and coagulation functions.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":7},{"id":"GO:0035264","count":7},{"id":"GO:0000122","count":6},{"id":"GO:0045766","count":6},{"id":"GO:0001867","count":6}]},{"hash":"1482290205257969576","title":"Neural signaling and sensory-behavioral processing","description":"The cluster centers on brain-related signaling and sensory/behavioral responses: dopaminergic synaptic transmission, ERK signaling, and behaviors such as cocaine response, along with visual perception and learning, and pain perception. While there are a couple of vascular/developmental brain terms, the dominant theme is neural signaling tied to sensory processing and behavior, supporting this label.","confidence":"High","size":28,"edges":266,"triangles":1288,"max_degree":26,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":26},{"id":"GO:0002035","count":26},{"id":"GO:0008542","count":26},{"id":"GO:0007601","count":26},{"id":"GO:0010759","count":26}]},{"hash":"1773594966598780228","title":"B cell signaling and innate immune defense","description":"This cluster\u2019s top GO terms are strongly immune-related, including B cell receptor signaling pathway, innate immune response, and defense response to virus, indicating a core theme of immune signaling and antiviral defense. Dendritic cell differentiation further supports an adaptive-innate immune interplay. Although a couple of terms relate to development or morphogenesis, the immune terms dominate, making this the most representative theme for the cluster.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0086091","count":3}]},{"hash":"2028088693572565296","title":"Brain development and inflammatory signaling","description":"This cluster centers on brain development but also prominently features signaling and inflammatory pathways (NF-kappaB, IL-1\u03b2, DAG, sphingolipid metabolism, thrombin receptor signaling), suggesting a neural-developmental program with lipid- and inflammation-related signaling.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007420","count":6},{"id":"GO:0016310","count":5},{"id":"GO:0006648","count":3},{"id":"GO:0032651","count":3},{"id":"GO:0051092","count":3}]},{"hash":"387130836398511090","title":"Neural development and synaptic signaling","description":"This cluster is dominated by GO terms for nervous system development, hippocampus development, and calcium-dependent exocytosis, along with dopamine response and signaling pathway regulation, pointing to a cohesive role in neuronal growth and synaptic transmission. Some immune-related terms are present but appear peripheral to the main neural-centric theme.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":24},{"id":"GO:0045956","count":24},{"id":"GO:0050771","count":23},{"id":"GO:0043366","count":23},{"id":"GO:0021766","count":23}]},{"hash":"1847539589082946554","title":"LPS-triggered innate immune response","description":"The top GO terms are dominated by innate immune response and cellular response to lipopolysaccharide, suggesting a common theme around host defense signaling in response to Gram-negative bacterial components. Some terms (e.g., ubiquitination regulation, lipid biosynthesis) are less directly tied to immunity, indicating the connection is present but not exclusively defining the cluster.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0031397","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0045600","count":4},{"id":"GO:0061014","count":4}]},{"hash":"680709482117485066","title":"Mitochondrial energy metabolism and protein import","description":"The cluster shows strong mitochondrial signals: proton-motive-force-driven ATP synthesis, ubiquinone biosynthesis, and protein import into the mitochondrial matrix, along with protein folding and translation\u2014together indicating mitochondrial biogenesis and bioenergetics. Some transcription-related terms appear, suggesting coordination with nuclear gene expression, but the core theme is mitochondrial function. ","confidence":"High","size":28,"edges":377,"triangles":3250,"max_degree":27,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0030150","count":4},{"id":"GO:0006355","count":3},{"id":"GO:0015986","count":3},{"id":"GO:0006744","count":2}]},{"hash":"657270353744704065","title":"Signaling and vesicle trafficking","description":"The GO terms point to a core theme of intracellular signaling (small GTPases, peptidyl-threonine phosphorylation, NFAT pathway, IGF receptor signaling) and membrane trafficking (ER-to-Golgi transport). Although terms cover immune, neural, and metabolic contexts, the shared function appears to be signaling networks linked to vesicle transport and regulation of downstream pathways, with phosphorylation as a common mechanism.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0043029","count":5},{"id":"GO:0048009","count":4},{"id":"GO:0051531","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0060079","count":4}]},{"hash":"1295569262345835374","title":"Neuronal signaling and synaptic function","description":"The Top Terms are dominated by nervous system processes: neuromuscular posture control, potassium ion transmembrane transport (neuronal excitability), synaptic vesicle clustering, regulation of neuron apoptosis, and visual perception. These together suggest a cohesive theme of neural signaling and synaptic machinery, with a few outliers (renal development, host-symbiont interactions) likely representing annotation noise or gene pleiotropy. Confidence: High.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050884","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0043524","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0046597","count":3}]},{"hash":"1387852289708449139","title":"Dopaminergic GPCR signaling and thermogenesis","description":"The set centers on dopamine-related synaptic transmission and GPCR-coupled signaling that activates adenylyl cyclase, with physiological outputs in blood pressure regulation and diet-induced thermogenesis, plus energy metabolism and membrane potential changes. This points to neuronal circuits where dopamine modulates energy expenditure and cardiovascular readiness via GPCR pathways.","confidence":"Medium","size":28,"edges":13,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":18},{"id":"GO:0010579","count":18},{"id":"GO:0045777","count":18},{"id":"GO:0022900","count":18},{"id":"GO:0002024","count":17}]},{"hash":"1603414576642486646","title":"Neural sensory perception and drug response","description":"The predominant GO terms point to neural functions and sensory processing (visual learning, visual perception, sensory perception of pain) and to drug- and behavior-related responses (response to morphine, behavioral response to cocaine). Additional terms touch on brain physiology (brain renin-angiotensin system) and signaling (positive regulation of GTPase activity) that can influence neural function. The combination suggests a cluster centered on neural/sensory processing and pharmacological behavioral responses rather than non-neural processes.","confidence":"Medium","size":28,"edges":6,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":25},{"id":"GO:0019233","count":25},{"id":"GO:0007507","count":25},{"id":"GO:0043547","count":25},{"id":"GO:0002035","count":25}]},{"hash":"1639154166437039717","title":"GPCR signaling in cardiovascular regulation","description":"The top GO terms center on GPCR signaling and its downstream effects, including regulation of heart contraction and vascular smooth muscle contraction, serotonin receptor signaling, GTPase activity, and dopamine secretion. Additional terms touch immune and neural-immune functions such as dendritic cell chemotaxis and eosinophil regulation, suggesting a broader GPCR-mediated signaling role that connects cardiovascular regulation with immune and neural processes. Overall, the proteins seem to cluster around GPCR-driven signaling that modulates cardiovascular physiology and related pathways.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":23},{"id":"GO:0031649","count":23},{"id":"GO:2000420","count":23},{"id":"GO:0001997","count":23},{"id":"GO:0045745","count":23}]},{"hash":"2166609310842676154","title":"Musculoskeletal Development and Mechanotransduction","description":"The cluster is enriched for skeletal muscle regeneration, bone development, collagen fibril organization, cellular responses to mechanical stimuli, and signal transduction, suggesting a core theme of mechanotransduction guiding musculoskeletal development and extracellular matrix remodeling. Regulatory processes like ubiquitination and CDK activity modulation may reflect broader control during differentiation; heart and brain terms appear but are less represented. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043403","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0045736","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0071260","count":3}]},{"hash":"261240640946378644","title":"Gene Expression Regulation and RNA Processing","description":"The top GO terms point to nuclear processes controlling gene expression, including transcription regulation (negative regulation of RNA Pol II), mRNA processing and splicing, rRNA maturation, and chromatin/DNA methylation-related regulation. Taken together, these terms suggest a cohesive role in regulating gene expression at multiple levels\u2014from transcription initiation and chromatin state to RNA processing and export. This cluster represents gene expression control via transcriptional and post-transcriptional processes.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0000055","count":2},{"id":"GO:0006346","count":2},{"id":"GO:0006349","count":2}]},{"hash":"1549088029072838678","title":"Neuro-immune signaling and development","description":"The terms show a mix of innate immune signaling (innate immune response, dsRNA response, interferon-\u03b2 production, LPS signaling) and neural development processes (axonal fasciculation, synapse assembly), all tied together by intracellular signal transduction. This suggests a cluster centered on signaling pathways that connect immune responses with nervous system development, rather than a single, narrow function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0001701","count":4},{"id":"GO:0035556","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0043330","count":3}]},{"hash":"1986188398523808291","title":"Unknown","description":"The Top Terms span development (midbrain-hindbrain boundary development, dorsal/ventral axis polarity), immune processes (immunoglobulin production, immune response), and remodeling/metabolism (bone remodeling, blood coagulation, cholesterol transport, integrin activation) with no clear, single functional theme tying them together, so there isn\u2019t a cohesive label to assign.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033622","count":2},{"id":"GO:0030917","count":2},{"id":"GO:0032367","count":2},{"id":"GO:0002642","count":2},{"id":"GO:2001274","count":2}]},{"hash":"1519114659946351374","title":"GPCR-driven cardiovascular signaling","description":"These proteins cluster around G protein-coupled receptor (GPCR) signaling and its downstream effects, including regulation of heart contraction by catecholamines, smooth muscle contraction, and adenylate cyclase pathways. The top terms emphasize GPCR signaling and cardiovascular regulation (e.g., heart contraction, vascular smooth muscle contraction, and GPCR pathway modulation), with additional linkage to chemotaxis, all pointing to a cohesive GPCR-mediated signaling module affecting cardiovascular physiology.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035625","count":25},{"id":"GO:0033861","count":24},{"id":"GO:0031649","count":24},{"id":"GO:2000420","count":24},{"id":"GO:0001997","count":24}]},{"hash":"1251347334188801707","title":"Immune signaling via NF-kappaB and interferon","description":"The most represented terms are immune-related: innate and adaptive immune responses, B cell receptor signaling, type II interferon production, and canonical NF-kappaB signaling, suggesting a cluster focused on immune signaling and response. A smaller set about translation initiation may reflect regulation of protein synthesis during activation but does not override the immune-centric theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006446","count":3},{"id":"GO:0007520","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0010765","count":3},{"id":"GO:0002250","count":3}]},{"hash":"868879896736397760","title":"Protein Quality Control via Ubiquitination and Autophagy","description":"The cluster is strongly enriched for post-translational modification and degradation terms: protein sumoylation, deubiquitination, macroautophagy, and ubiquitin-dependent ERAD, pointing to a coherent role in proteostasis and cellular quality control. The other terms (defense to fungus, amygdala development, and cell cycle regulation) appear as ancillary or broader functional associations, but do not override the central theme of protein turnover and regulation.","confidence":"High","size":27,"edges":289,"triangles":1805,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":14},{"id":"GO:0016579","count":11},{"id":"GO:0016236","count":9},{"id":"GO:0030433","count":8},{"id":"GO:0006777","count":7}]},{"hash":"1604535713031905580","title":"Developmental and immune signaling network","description":"The set includes developmental processes (Wnt signaling, axial mesoderm formation, dendritic spine morphogenesis) and immune signaling (T cell receptor signaling, muramyl dipeptide response), with supporting roles in RNA processing, DNA repair, and apoptosis, suggesting a cluster of regulators coordinating signaling and gene regulation across development and immunity.","confidence":"Medium","size":27,"edges":144,"triangles":275,"max_degree":21,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0060997","count":7},{"id":"GO:0009190","count":6},{"id":"GO:0090263","count":6},{"id":"GO:0045736","count":5},{"id":"GO:0032495","count":5}]},{"hash":"1177431996920233082","title":"Embryonic development and transcriptional regulation","description":"The top GO terms cluster around broad embryogenesis and organ morphogenesis (inner ear, endocrine pancreas, neural crest migration, cranial skeleton, primitive streak, digestive tract morphogenesis, ureteric bud branching) and, separately, mechanisms of gene expression control (negative and general transcription regulation, chromatin remodeling). This combination points to proteins that regulate development through transcriptional control, rather than a single tissue-specific function.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0048839","count":8},{"id":"GO:0090190","count":8},{"id":"GO:0031018","count":8},{"id":"GO:0001755","count":8}]},{"hash":"1139204391158888844","title":"Metabolism-Linked Immune Signaling","description":"The cluster\u2019s top GO terms span metabolic processes (L-serine biosynthesis, L-alanine catabolic process, pyridoxine and retinol metabolic processes) alongside immune and signaling pathways (Notch signaling, monocyte activation, cellular response to interleukin-1, and response to cAMP). This mix suggests proteins involved in basic metabolism that also participate in immune or inflammatory signaling rather than a single cohesive pathway.","confidence":"Medium","size":27,"edges":4,"triangles":1,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006564","count":6},{"id":"GO:0007219","count":6},{"id":"GO:0042853","count":5},{"id":"GO:0008615","count":5},{"id":"GO:0051591","count":5}]},{"hash":"281678560959761299","title":"Immune Activation and T Cell Signaling","description":"The top terms are dominated by immune processes: phagocytosis recognition, complement activation, T cell costimulation, and positive regulation of T cell proliferation, pointing to an immune activation cluster. Several terms related to development (lung mesenchyme, lateral mesoderm fate, FGFR signaling in brain development) may reflect gene multifunctionality or annotation noise, but they do not outweigh the immune signal.","confidence":"High","size":27,"edges":9,"triangles":7,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006910","count":10},{"id":"GO:0031295","count":8},{"id":"GO:0035584","count":7},{"id":"GO:0042102","count":7},{"id":"GO:0006958","count":7}]},{"hash":"1166428386513590332","title":"Innate Immune Response and Chemokine Production","description":"Based on the GO terms, the cluster is dominated by innate immunity, including innate immune response, chemokine production, neutrophil chemotaxis, cytotoxicity, and immunological memory. A few terms like development and transcription regulation are peripheral, but the core signals point to an immune-related module. Confidence: Medium","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0045087","count":4},{"id":"GO:0032602","count":4},{"id":"GO:0060021","count":3},{"id":"GO:0051592","count":3}]},{"hash":"1668415117655411634","title":"Calcium/NFAT signaling in heart and brain","description":"Top GO terms point to calcium-dependent signaling, especially calcineurin-NFAT regulation, with links to cardiac muscle contraction and memory-related processes. While some terms (e.g., bioluminescence, obsolete annotations) may be noisy, the core theme is calcium- and phosphatase-mediated signaling impacting heart and neural function, plus related signaling pathways like VEGF and cell shape regulation.","confidence":"Medium","size":27,"edges":44,"triangles":9,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":19},{"id":"GO:0007616","count":18},{"id":"GO:0006469","count":18},{"id":"GO:0060048","count":18},{"id":"GO:0007614","count":17}]},{"hash":"157768523314408287","title":"Rho-Actin Cytoskeleton Regulation","description":"The cluster shows enrichment for regulation of Rho protein signaling and actin crosslink formation, plus terminal web assembly and related cytoskeletal processes, suggesting a common theme of cytoskeletal dynamics and signaling that govern cell shape, movement, and division. Some terms reflect niche processes (ascospore formation, karyogamy, cardiac hypertrophy signaling), but the dominant signal centers on cytoskeletal regulation mediated by Rho pathways.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0007409","count":4},{"id":"GO:0000742","count":4},{"id":"GO:0051764","count":4},{"id":"GO:0030437","count":4}]},{"hash":"1348867915090374999","title":"DNA Damage Response, Apoptosis, and Innate Immunity","description":"The cluster centers on apoptosis and p53-mediated DNA damage signaling, with proteasomal degradation and cell cycle-related processes (mitotic spindle assembly), while also including innate immune responses (dsRNA sensing, interferon-beta production, LPS signaling), suggesting a stress-response program that links cell fate decisions to immune signaling.","confidence":"Medium","size":27,"edges":75,"triangles":73,"max_degree":26,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090307","count":11},{"id":"GO:0031146","count":11},{"id":"GO:0006915","count":9},{"id":"GO:0042771","count":9},{"id":"GO:0043547","count":8}]},{"hash":"1505635645005039745","title":"MAPK signaling and development regulation","description":"The proteins map to signaling cascades (positive regulation of JNK and ERK pathways, small GTPase-mediated signaling) and to developmental processes (brain development, dendrite development, epithelial polarity) as well as growth-related processes (cell cycle). This pattern suggests a cluster of regulators that integrate MAPK signaling with cellular architecture and development, rather than a single, isolated function.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0043552","count":6},{"id":"GO:0090162","count":6},{"id":"GO:0007049","count":6},{"id":"GO:0046330","count":5},{"id":"GO:0034198","count":5}]},{"hash":"183621609227139230","title":"DNA Repair and Genome Maintenance","description":"The cluster is dominated by GO terms related to DNA repair, replication, and telomere maintenance, indicating a set of proteins focused on genome stability and DNA damage response. Although some immune signaling terms (innate immune response, NF-kappaB related) appear, the core theme centers on repairing DNA and ensuring correct replication.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006281","count":6},{"id":"GO:0071479","count":5},{"id":"GO:0006260","count":4},{"id":"GO:0006284","count":4},{"id":"GO:0006261","count":4}]},{"hash":"1025861396483422682","title":"Social behavior and synaptic plasticity","description":"Most of the top GO terms cluster around neural processes governing social behavior and communication (social behavior, vocalization, male mating behavior) and learning/memory (long-term memory, visual learning) through synaptic changes (long-term potentiation/depression). A cohesive theme is thus proteins involved in social behavior circuits and learning via synaptic plasticity, with some broader sensory references. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":5},{"id":"GO:0035176","count":5},{"id":"GO:0008542","count":4},{"id":"GO:1900273","count":4},{"id":"GO:0071625","count":3}]},{"hash":"1508998812069342082","title":"Androgen signaling and prostate development","description":"The set is dominated by GO terms tied to male sex differentiation, prostate gland development, and steroid hormone receptor complex assembly, suggesting a core theme around androgen signaling in male tissues. There are also terms related to unfolded protein response and ubiquitination, which may reflect general cellular stress or quality control in secretory pathways, but they are secondary to the main hormone-driven development signal. Overall, the cluster seems best described by androgen receptor\u2013mediated prostate biology.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0046661","count":12},{"id":"GO:0071357","count":12},{"id":"GO:0051348","count":12},{"id":"GO:0030850","count":12},{"id":"GO:0006986","count":12}]},{"hash":"107452567265390096","title":"Visual and dopaminergic neural signaling","description":"This cluster is dominated by terms for visual perception/learning and dopaminergic synaptic transmission, plus related signaling (ERK cascade) and behavioral responses (cocaine). Together these indicate a focus on neural sensory processing and reward-related dopamine signaling, with some cross-talk to broader development terms. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":25},{"id":"GO:0019233","count":25},{"id":"GO:0007507","count":25},{"id":"GO:0007601","count":25},{"id":"GO:0071380","count":25}]},{"hash":"1377238690758373896","title":"Neural signaling and synapse organization","description":"The top GO terms cluster around neuronal communication, synapse targeting, and behavior: regulation of grooming and vocalization, protein localization to synapse, glutamate secretion, receptor clustering, and junctional/adherens assembly, plus sensory perception of light. This combination strongly suggests a neural signaling and synapse-focused module governing neural communication and behavioral responses, with some terms touching on myelin-related localization. Confidence: High.","confidence":"","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:2000821","count":15},{"id":"GO:0070433","count":15},{"id":"GO:0043113","count":15},{"id":"GO:0071625","count":14},{"id":"GO:0035418","count":13}]},{"hash":"266240537242519854","title":"Tissue morphogenesis and cell adhesion","description":"This cluster shows a strong representation of cell adhesion terms (heterophilic and homophilic), plus extracellular matrix and basement membrane development (ossification, glomerular basement membrane), and organ morphogenesis (retina morphogenesis, multicellular organism development). While there are a few immune-related terms, the dominant theme ties to cell\u2013cell and cell\u2013ECM interactions that drive tissue formation and development, so the label reflects a cohesive functional theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":15},{"id":"GO:0043931","count":13},{"id":"GO:0048661","count":11},{"id":"GO:0060042","count":11},{"id":"GO:0006958","count":11}]},{"hash":"1101209711877241432","title":"ER-Golgi transport and ribosome biogenesis","description":"Top GO terms indicate strong representation of ER-Golgi vesicle transport and retrograde Golgi-ER transport, as well as ribosomal large subunit biogenesis and LSU rRNA maturation. These points suggest the cluster centers on secretory pathway function alongside ribosome assembly, with additional signals of cell growth and development that may reflect broader cellular roles. Thus, the name captures the dominant themes of vesicle trafficking and ribosome biogenesis.","confidence":"Medium","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0000463","count":3},{"id":"GO:0006890","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006351","count":2}]},{"hash":"2176402097478328984","title":"Proteoglycan Biosynthesis with Inflammatory Signaling","description":"The cluster is dominated by GO terms for proteoglycan biosynthesis (chondroitin sulfate, heparan sulfate, proteoglycan) and related glycosylation processes, pointing to a core role in assembling extracellular matrix components. The presence of extrinsic apoptotic signaling, death-inducing signaling complex assembly, TNF production, and NF-kappaB signaling terms suggests these proteins also participate in inflammatory and apoptotic pathways, potentially linking proteoglycan metabolism to TNF/NF-\u03baB\u2013driven responses.","confidence":"Medium","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0050650","count":4},{"id":"GO:0006486","count":4},{"id":"GO:0015012","count":4},{"id":"GO:0030210","count":4},{"id":"GO:0097192","count":3}]},{"hash":"1160665340035099650","title":"Embryonic development and tissue morphogenesis","description":"This cluster is dominated by GO terms related to developmental processes across multiple tissues (endocardial EMT, cartilage morphogenesis, left/right patterning, pancreatic development, trophoblast and placental development, hair follicle morphogenesis, endocrine system development). Although there are a couple of general cellular-process terms (splicing, ubiquitin-dependent catabolic process), the common theme is embryonic development and tissue morphogenesis, suggesting these proteins collectively participate in organogenesis and lineage specification.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":9},{"id":"GO:0060536","count":9},{"id":"GO:0060972","count":9},{"id":"GO:0003323","count":9},{"id":"GO:0060707","count":9}]},{"hash":"1419709595264588345","title":"Mitochondrial central carbon metabolism","description":"The TOP terms center on energy metabolism: TCA cycle, mitochondrial electron transport (NADH to ubiquinone), and regulation of pyruvate decarboxylation to acetyl-CoA, with supporting signals from glycolysis and thiamine biosynthesis. This points to a cohesive cluster of proteins involved in mitochondrial energy production and central carbon metabolism, despite a few noisy, obsolete GO terms. ","confidence":"High","size":27,"edges":179,"triangles":404,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0006099","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0009083","count":2},{"id":"GO:0006096","count":2}]},{"hash":"850710796129604497","title":"Actin-based immune cell adhesion and migration","description":"The top GO terms cluster around actin-rich protrusions (filopodium and lamellipodium assembly), integrin activation, and Rho/GTPase signaling, all core to cytoskeletal remodeling, cell adhesion, and migration in immune cells. T cell activation via TCR/MHC interactions and hyaluronan metabolism further support coordinated immune cell activation and movement.","confidence":"","size":27,"edges":4,"triangles":0,"max_degree":4,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0046847","count":21},{"id":"GO:0033622","count":19},{"id":"GO:0045792","count":19},{"id":"GO:0030032","count":19},{"id":"GO:0002291","count":19}]},{"hash":"635341217060219289","title":"Mitochondrial energy metabolism and apoptosis","description":"The top GO terms are dominated by mitochondrial functions: NADH dehydrogenase to ubiquinone, complex II assembly, and mitochondrial translation/transcription, alongside apoptotic processes. Additional signals like ubiquitination and NF-kappaB regulation fit cellular stress responses linked to mitochondrial function. This suggests a cohesive theme around mitochondrial energy metabolism and mitochondrial-mediated apoptosis.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":2},{"id":"GO:0034553","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0043123","count":2}]},{"hash":"1341104177955074327","title":"ER Stress Response and Protein Folding","description":"The proteins are enriched for terms related to endoplasmic reticulum protein folding, ER stress and unfolded protein response, and ER-associated quality control (with supporting redox homeostasis). Transcription-related terms may reflect downstream regulatory responses. Overall, the cluster centers on ER protein quality control and stress response.","confidence":"High","size":27,"edges":37,"triangles":17,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034975","count":9},{"id":"GO:0045454","count":9},{"id":"GO:0000122","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0030433","count":6}]},{"hash":"808422033122289570","title":"Neural and organ development","description":"Top GO terms point to developmental processes across nervous system formation and organogenesis (nervous system development, midbrain-hindbrain boundary development, lung development, blood vessel remodeling, larval muscle development), plus regulation of differentiation timing and transcription. This suggests the cluster represents proteins involved in broader developmental programs rather than a single pathway, especially neural development and organ patterning.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0001974","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0030324","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1534476351438417018","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":17,"triangles":16,"max_degree":7,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0042273","count":7},{"id":"GO:0006412","count":6},{"id":"GO:0000463","count":6},{"id":"GO:0002181","count":5},{"id":"GO:0042254","count":3}]},{"hash":"633526605249759173","title":"LPS-induced NF-kappaB signaling","description":"The cluster centers on NF-kappaB pathway activity \u2014 including positive regulation of NF-kappaB transcription factor activity and canonical NF-kappaB signal transduction \u2014 and response to lipopolysaccharide, indicating an innate immune/inflammatory signaling theme. Additional terms for actin filament organization, Rho signaling, and ER stress response suggest concurrent cytoskeletal remodeling and cellular stress typical of activated immune cells. Overall, the dominant theme is NF-kappaB\u2013driven inflammatory signaling with related cytoskeletal dynamics.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0007015","count":3},{"id":"GO:0070373","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0043123","count":2}]},{"hash":"1665259086050108041","title":"Neural signaling and sensory perception","description":"The cluster is heavily enriched for GO terms tied to neural activity and perception: sensory perception of pain, visual perception/learning, dopaminergic synaptic transmission, and behavioral responses to cocaine, which together point to neural signaling and sensory processing. Additional signals such as cellular response to prostaglandin E and ERK cascade regulation are consistent with activity-dependent pathways in neurons. A few terms like heart development and macrophage chemotaxis appear, but the dominant pattern is neuronal communication and sensory function.","confidence":"High","size":27,"edges":49,"triangles":9,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":22},{"id":"GO:0071380","count":21},{"id":"GO:0006468","count":21},{"id":"GO:0008542","count":21},{"id":"GO:0007601","count":21}]},{"hash":"1939801955921095209","title":"Cardiac adrenergic GPCR signaling","description":"This cluster is dominated by GO terms for adenylate cyclase-activating GPCR signaling, GPCR pathway regulation, and heart/blood vessel functions (epinephrine/norepinephrine\u2013driven heart contraction, vascular smooth muscle contraction, and blood pressure regulation), indicating a central theme of adrenergic GPCR signaling controlling cardiac function and vascular tone. Energy-related terms (electron transport chain, heat generation) likely reflect metabolic support for contraction but do not redefine the main theme. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":26},{"id":"GO:0035025","count":26},{"id":"GO:0045777","count":26},{"id":"GO:0022900","count":26},{"id":"GO:0033861","count":25}]},{"hash":"824685164563742268","title":"GPCR-Mediated Cardiovascular Signaling","description":"Based on the GO terms, this cluster centers on GPCR signaling and its regulation, including serotonin receptor signaling, cAMP pathways, and downstream effects such as heart contraction and vascular smooth muscle activity, plus receptor-mediated modulation of dopamine and dendritic cell chemotaxis. The convergence on GPCR-driven signal transduction with cardiovascular and neural-immune readouts suggests a cohesive role in GPCR-mediated signaling affecting cardiovascular regulation.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":24},{"id":"GO:0031649","count":24},{"id":"GO:2000420","count":24},{"id":"GO:0001997","count":24},{"id":"GO:0045745","count":24}]},{"hash":"1762968226972361769","title":"Autonomic GPCR Signaling and Cardiovascular Regulation","description":"This cluster centers on GPCR signaling and its downstream regulation of cardiovascular and neural processes. The most represented GO terms include positive regulation of GPCR signaling, serotonin receptor\u2013mediated adenylate cyclase inhibition, and regulation of heart contraction by adrenergic signals, plus vascular smooth muscle contraction and dopamine secretion modulation. Immune cell trafficking via GPCR pathways (dendritic cell chemotaxis) also appears, suggesting a broader theme of GPCR-driven regulation across tissues.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":27},{"id":"GO:0031649","count":27},{"id":"GO:2000420","count":27},{"id":"GO:0001997","count":27},{"id":"GO:0045745","count":27}]},{"hash":"769230639659535535","title":"Unknown","description":"The top terms cover immune signaling, growth factor responses, cell division, chromatin modification, and protein degradation, with several terms marked obsolete and no connecting edges tying the proteins to a single function. There isn\u2019t a clear, cohesive theme to label the cluster, so it remains Unknown with no confidence.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097011","count":4},{"id":"GO:0006378","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0051225","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1035157214151712942","title":"Unknown","description":"The top GO terms are highly diverse, covering ubiquitin-mediated proteolysis, circadian rhythm regulation, muscle differentiation, tRNA modification, flower development, immune signaling, and various morphogenesis processes. There is no clear, single functional theme linking these terms, so a cohesive label cannot be assigned.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:0042752","count":12},{"id":"GO:0035914","count":9},{"id":"GO:0031591","count":8},{"id":"GO:0009911","count":8}]},{"hash":"1079052980950800794","title":"Rho GTPase and GPCR signaling","description":"The dominant shared function among the GO terms is signaling mediated by small GTPases and GPCR pathways: regulation of Rho protein signal transduction, small GTPase-mediated signal transduction, and G protein-coupled acetylcholine receptor signaling. This suggests the proteins are enriched for signaling components rather than purely enzymatic or developmental roles. Other terms such as proteolysis, digestion, heart development, and transcription appear but are less central to the main theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0007213","count":4},{"id":"GO:0007596","count":4}]},{"hash":"505588247913982176","title":"Ubiquitin-Dependent Proteolysis and Innate Immunity","description":"Dominant terms center on ubiquitin-dependent protein catabolism (ERAD, autoubiquitination, K6-linked ubiquitination) and innate immune signaling (defense against virus, TNF signaling, I-kappaB phosphorylation), implying a cluster of ubiquitin-proteasome regulators modulating immune responses.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":22},{"id":"GO:0045087","count":14},{"id":"GO:0030433","count":13},{"id":"GO:1903265","count":13},{"id":"GO:0051607","count":13}]},{"hash":"932063310842604531","title":"Neural development and ECM remodeling","description":"Based on the Top Terms, the proteins predominantly relate to nervous system development, including CNS development, axonal fasciculation, myelination, and synapse assembly. Collagen fibril organization points to extracellular matrix remodeling that supports neural tissue, while otolith morphogenesis and skeletal development terms reflect broader developmental roles. An innate immune response term may reflect glial functions but does not override the dominant neural development theme. Therefore the label captures the core function of the cluster.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001501","count":12},{"id":"GO:0007413","count":12},{"id":"GO:0007417","count":11},{"id":"GO:0014068","count":11},{"id":"GO:0030199","count":10}]},{"hash":"1827824715710906826","title":"Redox Homeostasis and Oxidative Stress Response","description":"This cluster is dominated by GO terms for cellular oxidant detoxification, redox homeostasis, cellular response to oxidative stress, and protein deglutathionylation, all signaling a cohesive focus on managing reactive oxygen species and maintaining redox balance. Some terms (methylamine metabolism, sodium transporter regulation) are ancillary but do not override the central redox theme.","confidence":"High","size":26,"edges":317,"triangles":2436,"max_degree":25,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0098869","count":15},{"id":"GO:0045454","count":13},{"id":"GO:0030416","count":11},{"id":"GO:0055114","count":10},{"id":"GO:2000651","count":7}]},{"hash":"947989862402438172","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":206,"triangles":755,"max_degree":25,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000398","count":7},{"id":"GO:0070935","count":6},{"id":"GO:0033129","count":6},{"id":"GO:1902416","count":6},{"id":"GO:0000278","count":5}]},{"hash":"64511552889816457","title":"Cardiovascular and metabolic organogenesis","description":"The top GO terms cluster around heart development, pancreatic morphogenesis, and adipocyte differentiation, plus cholesterol homeostasis and retinoic acid signaling. This points to a cohesive developmental program governing formation of cardiac and metabolic organs (heart, pancreas, fat tissue) with lipid regulation, rather than a single linear function. The connections to transcription factor activity (even if obsolete terms) reinforce coordinated gene regulation during organogenesis.","confidence":"High","size":26,"edges":58,"triangles":66,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":21},{"id":"GO:0045444","count":21},{"id":"GO:0051091","count":20},{"id":"GO:0035116","count":19},{"id":"GO:0072369","count":19}]},{"hash":"1556297718487178368","title":"Spliceosome-regulated mRNA processing","description":"The top GO terms cluster around spliceosome-mediated mRNA processing, including multiple aspects of splicing regulation (cis and alternative), along with mRNA export, stability, poly(A) tail regulation, and related RNA modification and translation reinitiation. This points to a coherent theme of post-transcriptional control and maturation of mRNA via spliceosome-driven pathways. ","confidence":"High","size":26,"edges":321,"triangles":2510,"max_degree":25,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":20},{"id":"GO:0048025","count":19},{"id":"GO:0045292","count":18},{"id":"GO:0048026","count":17},{"id":"GO:0031047","count":17}]},{"hash":"947421186262901690","title":"Embryogenesis and organ morphogenesis","description":"The cluster\u2019s top GO terms cluster around developmental processes and tissue formation, including oocyte localization in egg chamber formation, limb joint morphogenesis, renal vesicle formation, and heart-related development (regulation of heart rate by cardiac conduction, cardiac outflow tract proliferation). Additional terms on cell cycle and apoptosis reflect proliferation and remodeling that accompany development. Taken together, these terms suggest a cohesive developmental/morphogenetic program rather than a single housekeeping function.","confidence":"High","size":26,"edges":306,"triangles":2211,"max_degree":25,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":12},{"id":"GO:0015991","count":10},{"id":"GO:0030720","count":9},{"id":"GO:0043065","count":9},{"id":"GO:0003340","count":9}]},{"hash":"618070503009520689","title":"Innate Immune Signaling and Inflammatory Regulation","description":"The cluster is driven by innate immune response and regulation of TNF production, with several signaling pathways (Rap, Ral) and metabolic/signaling processes (insulin receptor signaling, focal adhesion regulation) that commonly interface with immune signaling; a few transcription-related terms likely reflect general cellular machinery rather than a separate module, but overall the theme centers on immune signaling and inflammation.","confidence":"Medium","size":26,"edges":94,"triangles":137,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0032760","count":5},{"id":"GO:0010667","count":5},{"id":"GO:0051973","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0051123","count":3}]},{"hash":"1614081229135729902","title":"Innate Immunity and Coagulation","description":"The cluster is dominated by innate immune and coagulation-related GO terms, including defense responses to fungi, neutrophil-mediated killing, leukocyte migration, blood coagulation, and plasminogen activation. While transcription regulation terms are present, the strongest cohesive signal is the link between immune defense and hemostasis, suggesting a module coordinating inflammation with vascular/coagulation processes. The midbrain development term may reflect pleiotropic transcription factors rather than a core theme of the cluster.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0030901","count":9},{"id":"GO:0045944","count":8},{"id":"GO:1903142","count":8},{"id":"GO:0001878","count":7}]},{"hash":"1238700429950052479","title":"Cell proliferation and ribosome biogenesis","description":"The set shows strong enrichment for cell division and mitotic cell cycle terms, plus ribosome biogenesis and translation-related processes, indicating a coordinated group involved in cell growth, division, and protein synthesis. This justifies a label centered on proliferation together with ribosome biogenesis.","confidence":"High","size":26,"edges":2,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0000747","count":6},{"id":"GO:0042254","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0035948","count":5}]},{"hash":"431364890989346211","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048105","count":26},{"id":"GO:0072137","count":26},{"id":"GO:0060901","count":26},{"id":"GO:0007420","count":26},{"id":"GO:0060490","count":26}]},{"hash":"1204382788971492260","title":"Neural and Muscular Development","description":"The top GO terms cluster around differentiation and development across neural, sensory, muscular, and cardiac lineages (axonogenesis, Schwann cell development, visual and sensory perception, myoblast fusion, heart development, multicellular organism development). There is also regulation of signaling and cell cycle activity, which can accompany developmental processes. The presence of abscisic acid-activated signaling likely reflects annotation noise across species. Overall, the theme is developmental programs coordinating tissue specification and organ formation in the nervous, sensory, and muscular systems.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007601","count":16},{"id":"GO:0007275","count":16},{"id":"GO:0007409","count":15},{"id":"GO:0019233","count":14},{"id":"GO:0009738","count":14}]},{"hash":"40708834994829798","title":"Spliceosome-Mediated mRNA Processing Regulation","description":"The top GO terms cluster around splicing and post-transcriptional mRNA processing, including spliceosome-mediated splicing, splice site recognition, regulation of alternative splicing, mRNA export, and mRNA modification. There are also signals for mRNA stability regulation and translation reinitiation, indicating a broader mRNA maturation and control program. Together these terms strongly point to proteins involved in splicing and processing of mRNA, justifying a label centered on mRNA splicing/processing regulation.","confidence":"High","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":26},{"id":"GO:0006406","count":18},{"id":"GO:0000380","count":18},{"id":"GO:0060211","count":18},{"id":"GO:0045292","count":18}]},{"hash":"1066803477263326670","title":"Immune signaling and actin cytoskeleton remodeling","description":"The GO terms point to immune system signaling events (B cell affinity maturation, B cell receptor signaling, interleukin-4 production, interleukin-7 response) together with cytoskeletal dynamics (regulation of Rho and Ras signaling, lamellipodium assembly, PI3K activity). This suggests a cohesive theme of immune cell activation paired with actin-driven motility and shape changes. Confidence: High","confidence":"","size":26,"edges":6,"triangles":0,"max_degree":3,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":19},{"id":"GO:0046580","count":17},{"id":"GO:0030593","count":16},{"id":"GO:0030032","count":16},{"id":"GO:0043552","count":15}]},{"hash":"1833002850952381588","title":"Glutamatergic Synaptic Transmission","description":"The top GO terms converge on excitatory synaptic activity and glutamate receptor signaling, including ionotropic glutamate receptor signaling, excitatory postsynaptic potentials, and regulation of synaptic transmission. Ion transport terms (sodium/potassium) and receptor internalization further support a neuronal glutamatergic synapse theme, making this a coherent label for the cluster.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0010226","count":2},{"id":"GO:0050806","count":2},{"id":"GO:0060992","count":2}]},{"hash":"731274834166559589","title":"Unknown","description":"These proteins have a mix of neural signaling, immune regulation, and broad developmental terms, with no clear shared pathway or interconnections (edges are zero). The diverse GO annotations do not point to a cohesive function, so a confident, representative label cannot be assigned.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060079","count":5},{"id":"GO:0043278","count":5},{"id":"GO:0046959","count":5},{"id":"GO:0033089","count":4},{"id":"GO:0045086","count":4}]},{"hash":"2064268400602590526","title":"Cardiac morphogenesis and heart development","description":"The cluster is dominated by GO terms tied to heart structure formation and development, including pulmonary artery, coronary artery, and pericardium morphogenesis, and involves signaling pathways (Notch, Wnt) and adhesion processes known to guide cardiac morphogenesis. While one term related to gamma-delta T cell differentiation is present, the overarching theme is cardiac development and tissue organization. High","confidence":"","size":26,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007157","count":19},{"id":"GO:2001027","count":18},{"id":"GO:0044332","count":18},{"id":"GO:1900127","count":18},{"id":"GO:0003270","count":17}]},{"hash":"2025057600443619272","title":"GPCR signaling with cardiovascular and immune roles","description":"This cluster centers on GPCR-related processes: positive regulation of GPCR signaling, serotonin receptor signaling (adenylate cyclase-inhibiting), regulation of GTPase activity, and dopamine secretion regulation. It also includes cardiovascular-related terms (heart contraction regulation, vascular smooth muscle contraction) and immune-affected processes (dendritic cell chemotaxis, eosinophil extravasation). The mix suggests proteins acting within GPCR signaling networks that influence both cardiovascular function and some immune cell behaviors, rather than a single tightly connected complex. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":25},{"id":"GO:0031649","count":25},{"id":"GO:2000420","count":25},{"id":"GO:0001997","count":25},{"id":"GO:0045745","count":25}]},{"hash":"1089866749149055586","title":"Pyroptosis and inflammatory cytokine production","description":"This cluster is dominated by GO terms tied to innate immunity, inflammatory cell death, and cytokine production (apoptotic process; pyroptotic inflammatory response; interleukin-1 beta and interleukin-18 production; innate immune response). Ubiquitination and NF-kappaB-related terms suggest regulation of these immune pathways, while a few terms like mitotic spindle assembly may reflect background associations or annotation noise. Overall, the core theme appears to be innate immune signaling coupled with pyroptosis and cytokine production.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006915","count":10},{"id":"GO:1990001","count":10},{"id":"GO:0045087","count":10},{"id":"GO:0016567","count":10},{"id":"GO:0070269","count":10}]},{"hash":"725019452927426805","title":"Immunometabolic Signaling","description":"The top GO terms mix immune activation (T cell activation via TCR-MHC) with metabolic and signaling pathways (insulin/IGF receptor signaling, glycogen biosynthesis, fatty acid transport, PI3K/Ras/Rho signaling). This suggests a theme where immune cell activation is closely tied to cellular metabolic signaling, i.e., immunometabolism. The lack of network edges doesn\u2019t contradict this broad functional link, given multi-function annotations. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0030212","count":20},{"id":"GO:0002291","count":19},{"id":"GO:2001275","count":19},{"id":"GO:0035023","count":19},{"id":"GO:0048009","count":19}]},{"hash":"29508673049640605","title":"Mitotic Cell Cycle Regulation","description":"The cluster is dominated by GO terms about G1/S transition, regulation of the cell cycle, and cyclin-dependent kinase activity, indicating a core module of mitotic cycle control and related transcriptional regulation; a few tissue-specific terms appear incidental.","confidence":"High","size":26,"edges":6,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000082","count":12},{"id":"GO:0000122","count":11},{"id":"GO:0045737","count":11},{"id":"GO:0071157","count":11},{"id":"GO:0006351","count":11}]},{"hash":"31259005207360805","title":"Ubiquitin-Proteasome\u2013Mediated Protein Degradation","description":"This cluster is strongly defined by ubiquitin-dependent protein catabolic processes and polyubiquitination, including SCF-dependent proteasomal degradation, pointing to proteostasis as the core function. The presence of circadian rhythm regulation terms suggests clock protein turnover via the ubiquitin-proteasome system, while links to neuronal stress signaling and DNA damage checkpoints imply broader roles in stress responses and neuron function. Overall, it represents a module centered on ubiquitin-proteasome\u2013mediated protein turnover.","confidence":"High","size":26,"edges":2,"triangles":0,"max_degree":2,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:0031146","count":12},{"id":"GO:0042752","count":11},{"id":"GO:1903378","count":11},{"id":"GO:0030433","count":10}]},{"hash":"205973452917076448","title":"Neurovascular development and innate immunity","description":"The proteins show strong signals for nervous system development (nervous system development, myelination, synapse assembly) and vascular/skeletal development (heart development, angiogenesis, skeletal system development), alongside innate immune responses (innate immune response, defense response to Gram-positive bacterium, response to lipopolysaccharide). This pattern suggests a developmental program coordinating neural and vascular growth with immune signaling, rather than a single isolated pathway.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050830","count":14},{"id":"GO:0045087","count":14},{"id":"GO:0014068","count":14},{"id":"GO:0051965","count":13},{"id":"GO:0007507","count":13}]},{"hash":"786349772379062583","title":"Ribosome biogenesis and translation","description":"GO terms indicate core roles in ribosome assembly and protein synthesis: cytoplasmic translation, ribosome biogenesis, ribosomal subunit export from the nucleus, and rRNA maturation processes. A nervous system development term appears as a less central annotation, but the dominant signal is ribosome-related functions.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0002181","count":3},{"id":"GO:0042274","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0000055","count":2},{"id":"GO:1903955","count":2}]},{"hash":"2252089250471006063","title":"Hippo-Wnt Growth Regulation and Craniofacial Development","description":"This cluster is dominated by terms tied to growth control and development, notably Hippo signaling and positive regulation of canonical Wnt signaling, alongside negative regulation of cell proliferation, apoptosis, keratinocyte differentiation, and embryonic cranial skeleton morphogenesis. The convergence on growth-control pathways and craniofacial development suggests a coherent theme of Hippo/Wnt\u2013mediated growth regulation and patterning affecting skin and craniofacial tissues.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008285","count":17},{"id":"GO:0006397","count":16},{"id":"GO:0006915","count":16},{"id":"GO:0060044","count":16},{"id":"GO:0035329","count":16}]},{"hash":"759360153790160248","title":"Ubiquitin-Dependent Immunity and Circadian Regulation","description":"The dominant GO terms point to ubiquitin-mediated protein turnover (ubiquitin-dependent catabolism, ubiquitination) and immune-related processes (germinal center formation, type 2 immune response, T cell differentiation). The presence of circadian rhythm regulation suggests temporal control of these immune functions. Together, these indicate a cluster centered on ubiquitin signaling in adaptive immunity, with circadian modulation.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0042787","count":21},{"id":"GO:0042752","count":11},{"id":"GO:0016567","count":8},{"id":"GO:0043380","count":8},{"id":"GO:2000176","count":8}]},{"hash":"2054048945771981291","title":"Neural stimulus-response signaling","description":"The GO terms emphasize neural and sensory processes (pain perception, vision), signaling pathways (neuropeptide signaling, prostaglandin response), and stimulus-driven behaviors (cocaine response). Temperature-related responses also fit into environmental stimulus processing. A few terms pertain to immune function, but they are less central to the dominant theme of neural sensory signaling, supporting a Neural stimulus-response signaling label.","confidence":"Medium","size":26,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":20},{"id":"GO:0002024","count":19},{"id":"GO:0071502","count":19},{"id":"GO:0071380","count":16},{"id":"GO:0030168","count":16}]},{"hash":"2266238845593945736","title":"Inflammation and vascular regulation","description":"The top GO terms cluster around inflammatory signaling (inflammatory response, response to LPS), coagulation and vascular regulation (blood coagulation, vasoconstriction, smooth muscle contraction), and thermoregulation/pain (temperature stimulus, diet-induced thermogenesis, pain perception), with saliva secretion suggesting exocrine involvement. This points to a coherent theme of innate immune-inflammatory response coupled with vascular control.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":25},{"id":"GO:0002024","count":24},{"id":"GO:0045986","count":24},{"id":"GO:0032496","count":24},{"id":"GO:0006954","count":24}]},{"hash":"55017025022023424","title":"GPCR Signaling Regulation and Catecholamine Response","description":"This cluster is dominated by GO terms related to regulation of GPCR signaling and downstream pathways (including GTPase activity and adenylate cyclase inhibition), plus physiological outputs linked to catecholamine signaling (heart contraction modulation by epinephrine/norepinephrine), vascular smooth muscle contraction, and neurotransmitter/immune cell dynamics (dopamine secretion and dendritic cell chemotaxis). The common thread appears to be modulation of GPCR-driven signaling cascades influencing cardiovascular, neural, and immune functions. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":24},{"id":"GO:0031649","count":24},{"id":"GO:2000420","count":24},{"id":"GO:0001997","count":24},{"id":"GO:0045745","count":24}]},{"hash":"1484146963671959628","title":"Cardiovascular and Neuroimmune GPCR Signaling","description":"This cluster centers on GPCR-related signaling and its downstream effects on heart contraction, vascular smooth muscle, and neural-immune processes (dopamine/serotonin signaling, dendritic cell chemotaxis, immune regulation), suggesting a shared GPCR-mediated regulatory role across cardiovascular and neural-immune contexts.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":26},{"id":"GO:0031649","count":26},{"id":"GO:2000420","count":26},{"id":"GO:0001997","count":26},{"id":"GO:0045745","count":26}]},{"hash":"408326945509201760","title":"Calcium- and GPCR-mediated vascular and metabolic signaling","description":"The top GO terms point to GPCR-activated signaling, calcium release and regulation (including release into cytosol), vascular functions (blood pressure regulation, coagulation), and metabolic processes (thermogenesis, electron transport). This suggests a cohesive theme of calcium- and GPCR-driven signaling that interfaces vascular regulation with metabolic energy control, even though some terms (pain, phototransduction) reflect broader signaling contexts. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":12},{"id":"GO:0010579","count":11},{"id":"GO:0035025","count":11},{"id":"GO:0022900","count":11},{"id":"GO:0007596","count":11}]},{"hash":"1563142102338329264","title":"Ion Channel\u2013Mediated Synaptic Signaling in Neurons","description":"The top GO terms cluster around ion transmembrane transport (K, Na, Ca), membrane depolarization, excitatory and inhibitory (EPSP/GABA) signaling, and sensory/behavioral processes (auditory perception, locomotion, taste aversion) with a note on circadian sleep regulation, pointing to neuronal ion transport and synaptic communication governing behavior and rhythmic activity.","confidence":"High","size":26,"edges":101,"triangles":132,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":23},{"id":"GO:0060079","count":22},{"id":"GO:0035725","count":22},{"id":"GO:0007626","count":20},{"id":"GO:0001661","count":20}]},{"hash":"2235844371244325657","title":"GPCR Signaling Regulation in Heart and Immune System","description":"The top GO terms cluster around GPCR signaling and its regulation, including positive regulation of GPCR signaling, adenylate cyclase-inhibiting serotonin receptor signaling, regulation of GTPase activity, and effects on vascular smooth muscle contraction and heart contraction. This points to proteins coordinating GPCR-driven signaling that influences cardiovascular function and immune/neural processes (e.g., dendritic cell chemotaxis and dopamine secretion), forming a cohesive functional theme.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":26},{"id":"GO:0031649","count":26},{"id":"GO:2000420","count":26},{"id":"GO:0001997","count":26},{"id":"GO:0045745","count":26}]},{"hash":"232871787450051722","title":"Xenobiotic and Nutrient Membrane Transporters","description":"This cluster is enriched for transmembrane transport terms across xenobiotics, vitamins, sugars (glucose, trehalose), and ions (potassium, organic anions), suggesting a set of diverse membrane transporter proteins handling a range of substrates rather than a single substrate class.","confidence":"High","size":26,"edges":276,"triangles":1650,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":25},{"id":"GO:0035461","count":25},{"id":"GO:0042908","count":23},{"id":"GO:0071805","count":22},{"id":"GO:0042891","count":20}]},{"hash":"1128172495685540224","title":"Ubiquitination and protein degradation","description":"Most top GO terms cluster around ubiquitin dynamics: ubiquitin-dependent protein catabolic process, protein ubiquitination, ubiquitin-autoubiquitination, and various ubiquitin linkage types (K63, linear), plus Congo ERAD-related processes. While there are a few peripheral terms (vitamin D response, T cell homeostasis, heart SA node action potential, mechanosensory pain), the dominant theme is ubiquitin-mediated protein modification and turnover. Confidence: High","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0033280","count":11},{"id":"GO:0016567","count":11},{"id":"GO:0098907","count":8},{"id":"GO:0051865","count":8}]},{"hash":"969440652469950781","title":"Ubiquitin-Dependent Protein Degradation","description":"Most abundant terms point to ubiquitin-mediated proteolysis (ubiquitin-dependent protein catabolic process, ERAD, autoubiquitination), indicating a cluster centered on targeted protein degradation via the ubiquitin-proteasome system. Secondary terms involve histone modification and signaling, but are less represented, suggesting these are auxiliary associations within the same protein set.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:0030433","count":10},{"id":"GO:0051865","count":10},{"id":"GO:0090073","count":10},{"id":"GO:0033280","count":9}]},{"hash":"1402485636123305419","title":"Adaptive immune signaling and angiogenesis","description":"This cluster is driven by immune-related GO terms: adaptive immune response, B cell receptor signaling, Fc-epsilon receptor signaling, and complement activation, with downstream ERK/MAPK signaling and receptor tyrosine kinase activation. The presence of angiogenesis and endothelial cell migration terms suggests a link between immune signaling and vascular remodeling. A CNS development term is present but less central to the core theme. Overall, the proteins appear to function in adaptive immune signaling with associated angiogenic processes, justifying the label.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0002250","count":16},{"id":"GO:0070374","count":14},{"id":"GO:0043536","count":13},{"id":"GO:0001867","count":13},{"id":"GO:0001525","count":13}]},{"hash":"2123753641506276181","title":"Diverse small-molecule biosynthesis","description":"The top GO terms cluster around biosynthesis of diverse small molecules (PHB, biopterin, phylloquinone, mycolic acids, retinoids/retinal, antibiotics, tropane alkaloids, androgens) and related metabolic processes, suggesting a broad, cross-kingdom set of metabolite synthesis pathways rather than a single cohesive pathway.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0042619","count":4},{"id":"GO:0006729","count":3},{"id":"GO:0042376","count":3},{"id":"GO:0071768","count":3}]},{"hash":"1666780687532183977","title":"Cardiovascular GPCR signaling and heart contraction","description":"The cluster is enriched for GO terms centered on GPCR signaling and GTPase regulation, with strong heart-related terms such as heart development, regulation of heart contraction by epinephrine/norepinephrine, and vascular smooth muscle contraction. This points to a cohesive theme of GPCR-mediated signaling controlling cardiovascular function, including heart muscle contraction and vasomotor tone. While some immune-related terms are present, they likely reflect broader GPCR roles rather than a separate function. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":22},{"id":"GO:0007507","count":22},{"id":"GO:0033861","count":21},{"id":"GO:0031649","count":21},{"id":"GO:2000420","count":21}]},{"hash":"2063822163136134651","title":"Adrenergic GPCR Signaling in Cardiovascular Regulation","description":"The top GO terms converge on G protein-coupled receptor signaling and downstream effects that modulate cardiovascular function: epinephrine/norepinephrine- related regulation of heart contraction, vascular smooth muscle contraction, and GPCR signaling amplification. Serotonin receptor signaling and adenylate cyclase inhibition also point to cAMP-mediated pathways linked to these processes. Some terms like fear response or heat generation are broader, but the central theme is GPCR-driven control of cardiac and vascular activity.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035625","count":19},{"id":"GO:0001662","count":18},{"id":"GO:0033861","count":17},{"id":"GO:0031649","count":17},{"id":"GO:2000420","count":17}]},{"hash":"157521981520225535","title":"Unknown","description":"The top GO terms are diverse, ranging from Wnt signaling and immune defense to pinocytosis, mechanosensing, telomere localization, and vitamin D response, with no single coherent function tying all proteins together. Therefore there isn\u2019t a clear, representative label beyond Unknown.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0016055","count":6},{"id":"GO:0048549","count":6},{"id":"GO:0071260","count":6},{"id":"GO:0070198","count":5},{"id":"GO:0098907","count":5}]},{"hash":"805707461303817350","title":"Unknown","description":"The cluster\u2019s top GO terms span kidney development (ureteric bud morphogenesis) and function (renal sodium ion absorption), nutrient-sensing pathways (TORC1, GCN2), circadian regulation of gene expression, RNA processing (snRNA export), and general cellular processes (cell division, pregnancy). There isn\u2019t a single cohesive theme tying these terms together, suggesting the proteins may be functionally diverse rather than a tight, interpretable module. Therefore, Unknown.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060733","count":2},{"id":"GO:0090190","count":2},{"id":"GO:0032922","count":2},{"id":"GO:0007565","count":2},{"id":"GO:0003016","count":2}]},{"hash":"2196181912121978196","title":"Unknown","description":"The Top Terms cover disparate processes\u2014positive regulation of GTPase activity, transcription, development, imprinting regulation, pancreatic juice secretion, rRNA maturation, mRNA splicing, actin depolymerization, mitotic spindle assembly, and histone acetylation\u2014indicating a heterogeneous set of functions rather than a single common theme. The lack of edges between proteins and the mix of nuclear, cytoskeletal, and developmental terms suggest there isn't a cohesive functional cluster; thus I cannot assign a specific, informative label beyond Unknown.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0006349","count":3},{"id":"GO:0030157","count":3}]},{"hash":"1078421199349948684","title":"Telomere maintenance regulation","description":"The cluster is enriched for GO terms related to telomere maintenance, telomere capping, and localization to telomeric regions, including both positive and negative regulation. This points to a shared function in protecting chromosome ends and regulating telomere length, with hints from associated DNA/chromosome organization and chromatin modification processes. While other signaling terms appear, the dominant theme among top terms is telomere biology.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0097284","count":6},{"id":"GO:1904357","count":5},{"id":"GO:1904355","count":5},{"id":"GO:0051225","count":5},{"id":"GO:0070212","count":5}]},{"hash":"1457998387438217854","title":"Vertebrate Development and Morphogenesis","description":"The top GO terms cluster around multicellular organism development and organ formation, including neural tube closure, hair follicle morphogenesis, kidney and skeletal system development, axonal fasciculation, and synapse assembly. Additional terms like cilium assembly and mitotic cell cycle fit into general developmental and cellular proliferation processes. Together, they point to a cohesive theme of vertebrate embryonic development and morphogenesis.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0001843","count":3},{"id":"GO:0060271","count":2},{"id":"GO:0031069","count":2},{"id":"GO:0001822","count":2}]},{"hash":"58817431728554590","title":"Transcription Regulation and Developmental Signaling","description":"Based on the top GO terms, the cluster is enriched for transcription by RNA polymerase II and a variety of signaling and developmental processes, including calcium signaling, neuromuscular junction assembly, leading-edge differentiation, wound healing, and locomotor rhythm, with a minor role in ER stress-related transcription and immune/apoptotic signaling. Taken together, the proteins appear to form a network coordinating transcriptional control with signaling events during development and tissue remodeling, particularly in neural-muscular contexts. Therefore the label Transcription Regulation and Developmental Signaling best reflects the dominant function, with moderate confidence given the diversity of terms.","confidence":"Medium","size":25,"edges":288,"triangles":2055,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0035470","count":10},{"id":"GO:0071277","count":8},{"id":"GO:1990440","count":7},{"id":"GO:0035026","count":7}]},{"hash":"1240647540510174566","title":"Embryonic organ development and patterning","description":"The GO terms span multiple tissues (heart, palate, neural crest, pancreas, spinal cord, brain, eye) and developmental contexts, plus a shared regulatory process, indicating a role in broad embryonic development and tissue specification rather than a single pathway.","confidence":"High","size":25,"edges":10,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0007507","count":8},{"id":"GO:0060021","count":8},{"id":"GO:0003309","count":7},{"id":"GO:0014029","count":7}]},{"hash":"493925139358910767","title":"Neural development and MAPK signaling inhibition","description":"Top GO terms emphasize dephosphorylation and negative regulation of signaling (ERK/MAPK cascade; TCR signaling; CDK activity) and include neural development terms (Bergmann glial differentiation; cerebellar cortex formation). This points to a cluster of protein tyrosine phosphatases and regulators that dampen signaling and participate in cerebellar neural development, making the label Neural development and MAPK signaling inhibition reasonable.","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":21},{"id":"GO:0050860","count":21},{"id":"GO:0000200","count":21},{"id":"GO:0035335","count":14},{"id":"GO:0045736","count":13}]},{"hash":"631534207321807381","title":"Neurodevelopment and Hormone Signaling","description":"The terms cluster around brain development (thalamus/striatum), neuroendocrine processes (adenohypophysis, male sex differentiation, steroid receptor assembly, prostate development), and neural function (glycinergic transmission, glial growth), suggesting a theme of brain development with hormonal regulation.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021794","count":7},{"id":"GO:0021756","count":7},{"id":"GO:0046661","count":4},{"id":"GO:0030850","count":4},{"id":"GO:0051301","count":4}]},{"hash":"901323980230472126","title":"Bone Formation and ECM Remodeling","description":"The cluster is enriched for bone- and ECM-related processes: intramembranous ossification, bone resorption, collagen catabolic processes, and basement membrane disassembly, indicating coordinated bone development with extracellular matrix turnover. Additional signals tied to development and remodeling (thyroid hormone response, Wnt-associated localization, immune/cell interactions) support a cohesive theme of bone/ECM remodeling and tissue architecture modification.","confidence":"High","size":25,"edges":235,"triangles":1215,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0010815","count":13},{"id":"GO:0001957","count":11},{"id":"GO:2000179","count":11},{"id":"GO:0035593","count":11},{"id":"GO:0097067","count":11}]},{"hash":"92085227135203136","title":"SMAD/TGF-\u03b2 signaling regulation in development","description":"These proteins cluster around modulation of TGF-\u03b2/BMP signaling and SMAD-related activity, with links to development (meristem identity) and regulatory trafficking (dephosphorylation, nuclear export, vacuole fusion). The common thread is controlled SMAD/TGF-\u03b2 signaling during development.","confidence":"Medium","size":25,"edges":217,"triangles":1127,"max_degree":23,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0030512","count":19},{"id":"GO:0046827","count":14},{"id":"GO:0035970","count":13},{"id":"GO:0061191","count":13},{"id":"GO:0030514","count":13}]},{"hash":"1835503082283044218","title":"Mitochondrial Metabolism and Translation","description":"The prominent GO terms point to mitochondrial activity\u2014TCA cycle, transsulfuration, redox homeostasis, and mitochondrial translation\u2014supporting a function centered on mitochondrial metabolism and protein synthesis. Some obsolete biosynthetic terms appear, likely due to older annotations, but the core theme remains mitochondrial energy and redox maintenance.","confidence":"High","size":25,"edges":51,"triangles":27,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":5},{"id":"GO:0009097","count":5},{"id":"GO:0019878","count":5},{"id":"GO:0019346","count":4},{"id":"GO:0043278","count":4}]},{"hash":"994975856196364713","title":"Pollen exine formation and anther dehiscence","description":"The cluster is enriched with GO terms directly tied to pollen development, notably pollen exine formation and anther dehiscence, indicating proteins involved in pollen wall biosynthesis and release. Additional terms for N-linked glycosylation and nucleotide-sugar catabolic processes align with secretory pathway and cell-wall-modifying activities necessary for pollen coat formation, supporting a cohesive role in pollen wall formation and anther dehiscence during male gametophyte development.","confidence":"High","size":25,"edges":271,"triangles":1727,"max_degree":24,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071405","count":10},{"id":"GO:0010584","count":10},{"id":"GO:0006256","count":10},{"id":"GO:0006487","count":10},{"id":"GO:0046712","count":10}]},{"hash":"1767022009720734985","title":"mRNA Splicing and Processing Regulation","description":"The cluster is enriched for spliceosome-mediated mRNA splicing with many terms about regulating splicing, plus related post-transcriptional mRNA processing steps such as export from the nucleus, polyadenylation/tail regulation, and mRNA modification, indicating a cohesive group involved in post-transcriptional maturation and control of gene expression.","confidence":"High","size":25,"edges":23,"triangles":1,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006406","count":3},{"id":"GO:0045292","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0006446","count":3},{"id":"GO:1900363","count":3}]},{"hash":"706688344986202162","title":"Hippo-Wnt Signaling and Differentiation","description":"This cluster is driven by prominent signaling pathway GO terms, especially Hippo and Wnt signaling, alongside processes that regulate cell proliferation and differentiation (e.g., negative regulation of cardiac muscle cell proliferation, keratinocyte differentiation) and apoptotic processes. The co-occurrence of transcription and various signaling pathways (including insulin receptor signaling) suggests a set of proteins coordinating development, growth control, and cell fate decisions, with additional immune signaling cues.","confidence":"High","size":25,"edges":28,"triangles":5,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006915","count":14},{"id":"GO:0035329","count":14},{"id":"GO:0060044","count":14},{"id":"GO:0030216","count":14},{"id":"GO:0090263","count":14}]},{"hash":"2117304863822456565","title":"Mitotic spindle assembly and chromosome segregation","description":"The top GO terms are dominated by mitosis-related processes: mitotic cell cycle, mitotic spindle assembly, mitotic sister chromatid segregation, and microtubule-based movement, indicating proteins involved in spindle dynamics and chromosome segregation. Supporting signals include positive regulation of GTPase activity and protein homooligomerization, which are consistent with control of motor proteins and assembly of multiprotein complexes in the mitotic apparatus. Although brain and spinal cord development terms appear, the core, strongest signal across the cluster is mitotic machinery rather than differentiation programs. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0051260","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0090307","count":4},{"id":"GO:0007018","count":4}]},{"hash":"1623809382314185979","title":"Xenobiotic and Nutrient Transmembrane Transport","description":"These proteins appear to function as membrane transporters handling xenobiotics, vitamins, sugars, ions, and other substrates, consistent with the prevalence of transmembrane transport GO terms (xenobiotic transport, vitamin transport, potassium ion transport, glucose transport, nitrate transport, etc.). The cluster thus represents a transporter-focused group rather than a single substrate pathway.","confidence":"High","size":25,"edges":22,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":25},{"id":"GO:0035461","count":25},{"id":"GO:0071805","count":20},{"id":"GO:0042908","count":20},{"id":"GO:0042891","count":16}]},{"hash":"1105029189727975321","title":"Steroid Hormone Biosynthesis and Reproduction","description":"The top GO terms cluster around testosterone biosynthesis and androgen metabolism, along with female gonad development and maternal parturition, indicating a theme of steroid hormone production and reproductive biology. Additional terms for prostaglandin/oxylipin biosynthesis and vitamin D response support a broader lipid-hormone signaling context, but the dominant signal is steroid hormone metabolism tied to reproductive processes.","confidence":"High","size":25,"edges":6,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0061370","count":16},{"id":"GO:0008209","count":16},{"id":"GO:0008585","count":13},{"id":"GO:0033280","count":12},{"id":"GO:0001516","count":12}]},{"hash":"611074933515116164","title":"Plant secondary metabolite biosynthesis","description":"Proteins in this cluster are strongly linked to plant secondary metabolism, including alkaloid (isoquinoline) metabolism, oxylipin biosynthesis, and ent-kaurene oxidation to kaurenoic acid (a gibberellin precursor). These themes point to plant chemical signaling and defense pathways as the shared function, with some non-plant terms likely reflecting cross-species annotations.","confidence":"High","size":25,"edges":42,"triangles":21,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0060137","count":25},{"id":"GO:0009822","count":25},{"id":"GO:0031408","count":25},{"id":"GO:0010241","count":25},{"id":"GO:0033280","count":25}]},{"hash":"2047981076848980664","title":"Unknown","description":"The GO terms in this cluster are highly diverse, spanning transcription regulation (positive and negative regulation of RNA polymerase II), nervous system functions (midbrain development, visual perception), immune processes (complement activation, neutrophil killing, response to yeast), blood coagulation, fertilization, and even an obsolete histone modification term. There is no clear, single functional theme tying these proteins together, suggesting either a mixed or noisy cluster or disparate annotations. ","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0030901","count":8},{"id":"GO:0007596","count":5},{"id":"GO:0045944","count":5},{"id":"GO:0006958","count":5}]},{"hash":"1052187358260471041","title":"ECM remodeling and innate immune signaling","description":"The top GO terms cluster around extracellular matrix remodeling (cell adhesion, collagen fibril organization, proteolysis) and immune signaling (innate immune response, T cell costimulation), with hints of mechanical stress and hypoxia responses. This suggests a functional theme of remodeling the extracellular environment while coordinating immune responses, possibly under stress. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":6},{"id":"GO:0030199","count":6},{"id":"GO:0045087","count":5},{"id":"GO:0006508","count":4},{"id":"GO:0051965","count":4}]},{"hash":"908531193732629944","title":"DNA replication and RNA processing","description":"The top terms cluster around DNA replication (unwinding, primer synthesis, topological changes, SOS response) and RNA processing (rRNA maturation, splicing, mRNA decay), suggesting a group of proteins involved in genome maintenance alongside RNA maturation/quality control. The presence of one unrelated term (associative learning) appears to be noise rather than a defining function of the cluster.","confidence":"Medium","size":25,"edges":30,"triangles":41,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006268","count":14},{"id":"GO:0006269","count":14},{"id":"GO:0000184","count":14},{"id":"GO:0006306","count":14},{"id":"GO:0009432","count":14}]},{"hash":"1496852531362900089","title":"Ubiquitin-Driven Protein Degradation and Signaling","description":"GO terms indicate a strong enrichment for ubiquitin-dependent protein catabolic processes, including autoubiquitination and ER-associated degradation, plus histone ubiquitination. There are also signals for regulation of TNF signaling and JNK cascade, and regulation of apoptotic processes. Together, these terms define a theme of ubiquitin-mediated proteolysis linked to inflammatory signaling and cell fate decisions, with possible chromatin regulation by ubiquitination. The cluster lacks measured edges, but the shared functional annotation justifies a single label.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:0051865","count":10},{"id":"GO:1903721","count":9},{"id":"GO:0030433","count":9},{"id":"GO:0070535","count":9}]},{"hash":"1836494477502841436","title":"Lipid Metabolism and Immune Signaling","description":"The top GO terms point to lipid biosynthesis and metabolism (ether lipid, triglyceride, CDP-diacylglycerol, platelet activating factor biosynthesis) alongside energy production (mitochondrial ATP synthesis) and immune signaling (interleukin-2 production, regulation of T cell activation-induced cell death). Although there are a couple of development-related terms, the core pattern ties lipid synthesis/metabolism to signaling processes, suggesting a functional cluster around lipid-related pathways and immune modulation.","confidence":"Medium","size":25,"edges":82,"triangles":151,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0002071","count":9},{"id":"GO:0042775","count":9},{"id":"GO:0070970","count":9},{"id":"GO:0006663","count":9},{"id":"GO:0008611","count":9}]},{"hash":"87961338965725589","title":"Cardiovascular and neural development signaling","description":"These proteins show enrichment for heart and labyrinthine layer blood vessel development, as well as neural synapse localization and dendritic spine morphogenesis, with Rho signaling and receptor clustering indicating cytoskeletal and adhesion remodeling. The combination suggests a shared developmental signaling theme affecting morphogenesis in cardiac/vascular and neural contexts, rather than a single pathway. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0043113","count":6},{"id":"GO:0007266","count":6},{"id":"GO:0060716","count":6},{"id":"GO:0035418","count":6}]},{"hash":"2233607788640037121","title":"Vertebrate Development and Tissue Differentiation","description":"This cluster is enriched for developmental GO terms across multiple tissues (nervous system, heart, lens, palate, olfactory bulb) plus DNA-templated transcription, indicating a role in vertebrate organogenesis and differentiation rather than a single, specific pathway.","confidence":"Medium","size":25,"edges":23,"triangles":0,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0070306","count":4},{"id":"GO:0060021","count":3},{"id":"GO:0001707","count":3},{"id":"GO:0030433","count":3}]},{"hash":"640499054898169093","title":"Vesicle trafficking and autophagy cluster","description":"The top GO terms cluster around intracellular membrane trafficking (ER\u2013Golgi and endosome\u2013lysosome transport), autophagy, and apoptotic processes, with additional regulation of GTPase activity. This suggests a cohesive group of proteins involved in vesicle transport and degradation pathways, often engaged during cellular stress, with some development-related terms appearing but likely reflecting broader shared pathways rather than a dedicated developmental module.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0006914","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0071260","count":3}]},{"hash":"2002206492113789079","title":"Kinase-driven signaling and cytoskeletal remodeling","description":"The GO terms cluster around phosphorylation regulation (autophosphorylation, kinase activity), regulation of GTPase activity, actin crosslinking, endocytosis, and intracellular transport, with an immunoreceptor signaling link (Fc-epsilon receptor). Together they suggest signaling cascades that govern cytoskeletal dynamics and membrane trafficking mediated by kinases.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0031954","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0051764","count":6},{"id":"GO:0038095","count":6}]},{"hash":"1615955462270901496","title":"Apoptosis and innate immune signaling","description":"This cluster is dominated by terms related to programmed cell death and inflammatory responses, including necroptotic signaling, extrinsic apoptotic signaling, and NF-kappaB\u2013related transcriptional activity, along with lipopolysaccharide-mediated signaling. These converge on stress-triggered cell fate decisions and innate immune activation. Other terms like nicotine response and chloride transport are less central but may reflect broader stress and ion homeostasis contexts. Confidence: Medium","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:1902476","count":2},{"id":"GO:2000353","count":2},{"id":"GO:0051092","count":2},{"id":"GO:2001240","count":2}]},{"hash":"57958330663214166","title":"Nuclear transcription initiation and chromatin regulation","description":"The cluster\u2019s GO terms predominantly reflect nuclear gene expression and chromatin state, including RNA polymerase II preinitiation complex assembly, maintenance of protein location in the nucleus, and histone H3 acetylation. These point to transcription initiation control and chromatin regulation as core themes. Additional terms touch on development and cell-cycle regulation, which are biologically connected to gene expression programs, while lipid biosynthesis and viral processes appear more peripheral noise, not defining the cluster. Overall, the central theme is nuclear transcription machinery and chromatin modification.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046854","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0051457","count":2},{"id":"GO:0043966","count":2},{"id":"GO:0039702","count":2}]},{"hash":"1733545079196237552","title":"Neural development and immune signaling","description":"The top GO terms blend neural development (forebrain development, neural tube closure, multicellular organism development) with immune signaling (NF-kappaB activity, cellular response to lipopolysaccharide, T cell receptor signaling, nitric oxide response), suggesting a cluster spanning both neurodevelopmental and immune-related processes. Given the mix and no network connectivity, the label captures the dominant themes without overclaiming a single cohesive function.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0045471","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0030900","count":3}]},{"hash":"2195884048423148668","title":"Bacterial Energy Metabolism and Quinone Biosynthesis","description":"The cluster is driven by central metabolic and quinone-related processes (TCA cycle, aerobic respiration, beta-oxidation, menaquinone/phylloquinone biosynthesis). Other GO terms suggest related bacterial metabolism, while translation is less representative.","confidence":"High","size":25,"edges":299,"triangles":2277,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0010124","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0009234","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0042372","count":3}]},{"hash":"898855068339376782","title":"Inflammation-driven vascular signaling and coagulation","description":"The GO terms prominently include inflammatory response, lipopolysaccharide response, pain perception, blood coagulation, and vasoconstriction, plus GPCR signaling and lipid signaling that modulate vascular tone. This points to a functional module where inflammation interfaces with vascular regulation and hemostasis, rather than a simple metabolic process, hence this label.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":20},{"id":"GO:0045745","count":19},{"id":"GO:0045986","count":19},{"id":"GO:0006954","count":19},{"id":"GO:0032496","count":19}]},{"hash":"238257118132783210","title":"Diverse specialized metabolite biosynthesis","description":"This cluster features multiple GO terms focused on biosynthetic pathways for a range of specialized metabolites and cofactors (tetrahydrobiopterin, phylloquinone, retinoic/retinal products, fatty acids, mycolic acids, antibiotics, and alkaloids), suggesting proteins involved in diverse metabolite biosynthesis. A few catabolic terms are present, but the dominant signal is biosynthesis of varied compounds. ","confidence":"Medium","size":25,"edges":4,"triangles":1,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0006729","count":4},{"id":"GO:0042376","count":4},{"id":"GO:0071768","count":4},{"id":"GO:0006710","count":4}]},{"hash":"2158942923662460183","title":"Unknown","description":"The top GO terms cover very diverse processes (lung epithelial differentiation, cardiac remodeling, drug responses, cell cycle and DNA replication, immune homeostasis, glycosylation, and stem cell differentiation) with no clear shared function or connectivity, so a coherent, specific label cannot be assigned.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060487","count":4},{"id":"GO:0014898","count":3},{"id":"GO:0042220","count":3},{"id":"GO:0000082","count":3},{"id":"GO:0043029","count":3}]},{"hash":"1092344075330176919","title":"Proteasome-mediated protein degradation and signaling","description":"This cluster is dominated by GO terms for proteasome-related processes (proteasome core complex assembly, SCF-dependent proteasomal ubiquitin-dependent degradation, ubiquitin-independent proteasomal catabolic processes) and includes signaling pathways (T cell receptor signaling, Rho signal transduction, and both positive/negative regulation of canonical Wnt signaling). The convergence of protein turnover mechanisms with these signaling pathways suggests a shared role in proteostasis coupled to regulation of cellular signaling, with additional stress-related terms (cadmium response) and post-transcriptional control (mRNA stability) supporting a broader \u201cprotein turnover and signaling regulation under stress\u201d theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046686","count":6},{"id":"GO:0043488","count":5},{"id":"GO:0051436","count":5},{"id":"GO:0050852","count":5},{"id":"GO:0090090","count":5}]},{"hash":"448868883444273246","title":"ER-Golgi vesicle trafficking and ribosome biogenesis","description":"This cluster centers on intracellular transport between the ER and Golgi (anterograde and retrograde transport) and on ribosome biogenesis, with links to TORC1 signaling and cell growth/division. The top GO terms strongly point to secretory pathway activity and assembly of ribosomes, suggesting a coordinated role in protein trafficking and production that supports growth. Some growth- or defense-related terms may be ancillary or reflective of broader cellular states, but the dominant theme is vesicle trafficking plus ribosome biogenesis. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006888","count":6},{"id":"GO:0051028","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0006890","count":4},{"id":"GO:0051301","count":4}]},{"hash":"779451804254931649","title":"Ion Transport and Membrane Potential Regulation","description":"The top GO terms cluster around sodium and potassium ion movement across membranes, regulation of transmembrane transporter activity, and maintenance of the transmembrane electrochemical gradient, pointing to a core function in ion homeostasis and membrane potential control. A minority of terms relate to mitochondrial protein import, which may reflect localization signals rather than a core function of the cluster. Given the lack of interaction edges, the assignment relies on shared functional annotations rather than network connectivity.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:1903278","count":3},{"id":"GO:0036376","count":3},{"id":"GO:2000649","count":3},{"id":"GO:0086036","count":3},{"id":"GO:0090662","count":3}]},{"hash":"263318651218315933","title":"Transcriptional Regulation and ER Stress Response","description":"Top GO terms center on controlling gene expression (negative regulation of RNA Pol II transcription, transcription factor activity) and cellular stress handling (ER stress, protein folding in ER, oxidative stress). Additional terms relate to cell division (mitotic cytokinesis, microtubule depolymerization) and development, suggesting a cluster of regulatory proteins that coordinate transcription with stress responses and cell-cycle processes.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007026","count":3},{"id":"GO:0000281","count":3},{"id":"GO:1903026","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0032088","count":2}]},{"hash":"754104975049616385","title":"Transmembrane and Vesicle Transport Proteins","description":"This cluster is dominated by GO terms for transmembrane transport across membranes, including potassium ions, galactose, and xenobiotics, plus a term related to neurotransmitter loading into synaptic vesicles. While there are a couple of cell division/cell cycle terms present, the strongest and most coherent signal is membrane transport and vesicle-associated transport, suggesting these proteins function primarily as transporters or vesicular transport components.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0071492","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0007049","count":2}]},{"hash":"636357397895757719","title":"Broad microbial metabolism and detoxification","description":"The top GO terms show a mix of metabolic processes: detoxification of oxidants, various catabolic and biosynthetic pathways (beta-ketoadipate, 1,2-dichloroethane degradation, biotin and antibiotic biosynthesis), and related redox reactions. This pattern points to proteins involved in diverse microbial metabolism rather than a single specific function. A couple of terms (sensory perception of smell, regulation of cell proliferation) appear less aligned and may reflect annotation noise, but the dominant signal is broad metabolic activity and detoxification.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008284","count":4},{"id":"GO:0098869","count":4},{"id":"GO:0019433","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0007608","count":4}]},{"hash":"811113742846736893","title":"Dendrite development and actin remodeling","description":"The cluster shows strong representation of dendrite development and morphogenesis terms (dendrite development, dendrite morphogenesis, positive regulation of dendrite development) along with actin cytoskeleton dynamics (actin filament bundle assembly, filopodium assembly). This points to neuronal morphogenesis driven by actin remodeling and cell adhesion. While lysosome-related processes and lung alveolus development are present, the dominant theme appears to be dendritic growth linked to cytoskeletal remodeling.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006146","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0032418","count":2},{"id":"GO:1900006","count":2}]},{"hash":"1871187882837072921","title":"Embryonic Development and Organ Morphogenesis","description":"The proteins are enriched for diverse developmental processes, including endocrine system development, placenta and cartilage morphogenesis, left-right patterning, craniofacial (roof of mouth) development, pancreatic cell development, and EMT in heart cushions, all pointing to embryogenesis and organ formation with underlying transcriptional regulation.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0060021","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0060707","count":4}]},{"hash":"1631415014040869659","title":"Unknown","description":"The GO terms are spread across telomere maintenance regulation, spindle assembly, adipogenesis, synapse assembly, migration, and PARP-related modification, with no single cohesive function linking all proteins. The lack of a clear shared pathway or theme and no edges makes a concise, representative label untenable.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":6},{"id":"GO:1904355","count":5},{"id":"GO:2001275","count":5},{"id":"GO:0032212","count":5},{"id":"GO:0051965","count":5}]},{"hash":"1184792204639885985","title":"Cerebellar neuron and Bergmann glia development","description":"This cluster is dominated by cerebellar-focused terms (cerebellar cortex formation, Bergmann glial cell differentiation, neuron development, regulation of axon regeneration), pointing to cerebellar neural development and Bergmann glia differentiation as the core theme. Other terms like insulin signaling and ERK cascade regulation appear supplementary but do not override the cerebellar emphasis.","confidence":"High","size":24,"edges":119,"triangles":151,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008286","count":7},{"id":"GO:0032435","count":7},{"id":"GO:0048679","count":7},{"id":"GO:0050852","count":7},{"id":"GO:0048666","count":7}]},{"hash":"354905829036184906","title":"Neural Development and Synaptic Signaling","description":"Enriched GO terms center on nervous system development and synaptic function: axonogenesis, Schwann cell development, visual perception, long-term synaptic potentiation, and excitatory postsynaptic potential, plus regulation of peptidyl-threonine phosphorylation. While other terms (heart development, G2/M transition) appear, the strongest signal is neural development and synaptic signaling, suggesting the proteins in this cluster participate in neurodevelopment and neuron communication. The ABA pathway term is plant-specific and likely reflects annotation breadth or cross-species overlap.","confidence":"Medium","size":24,"edges":22,"triangles":4,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0009738","count":18},{"id":"GO:0014044","count":18},{"id":"GO:0007409","count":18},{"id":"GO:0007601","count":18},{"id":"GO:0043065","count":18}]},{"hash":"601147376587931937","title":"Kinetochore-associated mitosis and cell cycle","description":"Most terms describe mitosis and the cell cycle, especially localization to the kinetochore, G1/S and G2/M transitions, and sister chromatid biorientation. While a few terms touch on transcription and development, the unifying theme is mitotic progression and kinetochore function, indicating this cluster comprises proteins coordinating chromosome segregation and cell-cycle control.","confidence":"High","size":24,"edges":249,"triangles":1527,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034501","count":10},{"id":"GO:0007049","count":10},{"id":"GO:0001701","count":10},{"id":"GO:0000082","count":10},{"id":"GO:0000086","count":10}]},{"hash":"71308932331107497","title":"Neuronal signaling and synaptic plasticity regulation","description":"This cluster shows enrichment in neuronal-related functions such as short-term memory and long-term synaptic potentiation, along with positive regulation of kinase activity (GTPase activity, serine/threonine kinase activity, autophosphorylation) and mRNA transport, pointing to coordinated signaling and synaptic regulation. Some terms (e.g., karyogamy, hypoxia response, apoptosis) are broader or non-neuronal, but the dominant theme appears to be regulation of signaling pathways underlying synaptic function.","confidence":"Medium","size":24,"edges":157,"triangles":413,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000742","count":12},{"id":"GO:0007614","count":11},{"id":"GO:0043547","count":11},{"id":"GO:0071456","count":11},{"id":"GO:0006919","count":11}]},{"hash":"94335749005534629","title":"Neural development and axon guidance","description":"This cluster is dominated by GO terms related to nervous system development, neuron migration, axon guidance, and synapse assembly, with prominent cell adhesion terms. Although bone/ossification terms appear, the strongest signal centers on neural development and connectivity, suggesting roles in neuronal adhesion, migration, and synaptic organization.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":13},{"id":"GO:0007156","count":13},{"id":"GO:0051965","count":12},{"id":"GO:0043931","count":12},{"id":"GO:0007399","count":11}]},{"hash":"1786257968086283495","title":"Vertebrate organogenesis","description":"Top GO terms point to development across multiple vertebrate tissues (brain/forebrain, neural crest, liver, digestive tract, uterus) plus regulatory processes (transcriptional regulation, cell cycle, nervous system\u2013related control). This indicates a coherent theme of vertebrate organ formation and developmental regulation rather than a single tissue-specific function.","confidence":"Medium","size":24,"edges":28,"triangles":1,"max_degree":20,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0007420","count":6},{"id":"GO:0001889","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0030900","count":4},{"id":"GO:0048565","count":4}]},{"hash":"1958576381351283355","title":"Spliceosome-Driven mRNA Processing and Export","description":"The top GO terms cluster around mRNA splicing via the spliceosome (including alternative splicing regulation), mRNA export from the nucleus, polyadenylation and tail processing, and general mRNA modification, indicating proteins focused on nuclear mRNA maturation and processing prior to translation.","confidence":"High","size":24,"edges":124,"triangles":251,"max_degree":20,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":14},{"id":"GO:0006378","count":13},{"id":"GO:0045292","count":12},{"id":"GO:0006406","count":11},{"id":"GO:0000380","count":11}]},{"hash":"848050609675379823","title":"Neuronal neurotransmitter release and vesicle fusion","description":"The cluster is enriched for GO terms tied to neurotransmitter regulation and synaptic signaling, especially dopamine secretion and GABAergic transmission, along with processes of vesicle fusion and calcium-dependent exocytosis. The IP3 biosynthetic process and calcium-related exocytosis support a theme of intracellular Ca2+-triggered neurotransmitter release and synaptic vesicle trafficking. While some terms (egg activation, ABA signaling, angiogenesis-related) seem less related, the dominant signals point to neuronal synaptic function and vesicle dynamics.","confidence":"High","size":24,"edges":27,"triangles":0,"max_degree":20,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0014059","count":5},{"id":"GO:0032228","count":5},{"id":"GO:0007343","count":4},{"id":"GO:1990927","count":4},{"id":"GO:0036324","count":4}]},{"hash":"1691977649669778465","title":"Neurodevelopmental Signaling Network","description":"The top GO terms are dominated by nervous system development and brain development, with additional signaling pathways such as Hedgehog (Smoothened), Roundabout (ROBO), and ERK cascade regulation, plus regulation of synaptic vesicle exocytosis. While there are other development-related terms (kidney development, T cell signaling), the shared theme is developmental signaling networks centered on neurodevelopment and synaptic processes, suggesting proteins that coordinate neural differentiation and synaptic function.","confidence":"High","size":24,"edges":254,"triangles":1586,"max_degree":23,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":14},{"id":"GO:0050852","count":13},{"id":"GO:0007420","count":12},{"id":"GO:0007224","count":10},{"id":"GO:0035385","count":10}]},{"hash":"886077020574058864","title":"Dendrite Morphogenesis and Nervous System Development","description":"Most top GO terms cluster around neural development and morphogenesis, especially dendrite morphogenesis, hippocampus development, and general nervous system development, with supporting signaling and cytoskeletal regulation (JNK cascade, serine phosphorylation, actin remodeling). A small set of terms like beta selection and T cell receptor signaling appear incidental, but the dominant theme is neural development.","confidence":"High","size":24,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048813","count":20},{"id":"GO:0043552","count":20},{"id":"GO:0050771","count":19},{"id":"GO:0043366","count":19},{"id":"GO:0021766","count":19}]},{"hash":"810231092637714020","title":"Immune migration and neural development","description":"The top GO terms cluster around immune cell movement (neutrophil chemotaxis), cytotoxicity, apoptosis, and cell adhesion/signaling (cell shape regulation, integrin biosynthesis), along with neural context signals (astrocyte development, memory) and calcium-responsive signaling. The mix suggests proteins involved in coordinated signaling, adhesion, and movement that span immune and neural development contexts, rather than a single narrow function. ","confidence":"Medium","size":24,"edges":19,"triangles":3,"max_degree":7,"top_function":"wound healing","top_go_terms":[{"id":"GO:0051290","count":23},{"id":"GO:0000122","count":22},{"id":"GO:0051592","count":15},{"id":"GO:0014002","count":15},{"id":"GO:0008360","count":15}]},{"hash":"195311653940492836","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":20},{"id":"GO:0031047","count":20},{"id":"GO:0000398","count":18},{"id":"GO:0071031","count":16},{"id":"GO:0006369","count":16}]},{"hash":"2219318874573531086","title":"Platelet activation and coagulation signaling","description":"This cluster strongly features terms tied to hemostasis and platelet function, including blood coagulation, regulation of fibrinolysis, integrin activation, and Rho signaling, along with cellular responses to mechanical stimuli and cAMP signaling, all of which are central to platelet adhesion, shape change, and clot formation. One outlier term (mating plug formation) is less related, but the dominant theme supports a coagulation/platelet signaling interpretation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein maturation","top_go_terms":[{"id":"GO:0071260","count":8},{"id":"GO:0042628","count":7},{"id":"GO:2001275","count":7},{"id":"GO:0051918","count":6},{"id":"GO:0007596","count":6}]},{"hash":"992009717999573384","title":"Collagen Biosynthesis and ECM Remodeling","description":"The top GO terms center on collagen fibril organization, collagen biosynthetic and catabolic processes, and skin/connective tissue development, pointing to extracellular matrix formation and remodeling as the core theme; immune-related terms are present but secondary.","confidence":"High","size":24,"edges":94,"triangles":132,"max_degree":20,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030199","count":10},{"id":"GO:0001867","count":8},{"id":"GO:0007596","count":8},{"id":"GO:0034381","count":7},{"id":"GO:0030574","count":7}]},{"hash":"122680314184021877","title":"Immune development and DNA repair","description":"This cluster centers on immune system development (spleen and lymph node development) and inflammatory response, with multiple DNA repair pathways represented (NER, BER, NHEJ) and somatic hypermutation, suggesting a link between immune maturation and DNA repair/gene diversification.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007568","count":5},{"id":"GO:0051402","count":4},{"id":"GO:0048536","count":4},{"id":"GO:0048535","count":4},{"id":"GO:0006954","count":4}]},{"hash":"930018927880915709","title":"Retinoid and carbohydrate metabolism cluster","description":"Core retinoid metabolism signals (retinal and retinol) dominate, with additional metabolic terms for arabinose, sorbitol, glucuronate, and bile acids, pointing to a broader carbohydrate- and lipid-related catabolic network. The inclusion of tissue homeostasis and regulation of apoptosis suggests these proteins participate in cellular maintenance. Some developmental terms (male gonad development, smooth muscle proliferation) may reflect broader regulatory roles rather than a single pathway. Overall, the cluster centers on retinoid metabolism with broader metabolic/homeostatic functions.","confidence":"Medium","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":24},{"id":"GO:0042572","count":24},{"id":"GO:0048661","count":18},{"id":"GO:0019568","count":18},{"id":"GO:0030573","count":18}]},{"hash":"1276409544269721341","title":"Wnt-driven development and morphogenesis","description":"The top terms cluster around developmental processes and tissue morphogenesis, including Wnt signaling, midbrain development, pancreas morphogenesis, and biomineral tissue development. While there are outlier immune-related terms (neutrophil killing), the dominant theme is development with Wnt signaling linked to morphogenesis.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0000122","count":15},{"id":"GO:0030901","count":10},{"id":"GO:0016055","count":9},{"id":"GO:0001878","count":8},{"id":"GO:0070946","count":8}]},{"hash":"1460539596871814652","title":"Steroid Hormone and Vitamin D Metabolism","description":"This cluster is rich in GO terms for steroid/hormone biosynthesis and metabolism (testosterone biosynthetic process, androgen metabolic process) and vitamin D-related processes (response to vitamin D, vitamin D catabolic process), with supporting lipid-related pathways (oxylipin biosynthetic process) and hormone-linked physiological processes (maternal process involved in parturition). Although a plant-specific term appears (ent-kaurene oxidation), the overall theme points to hormone- and vitamin D\u2013related metabolism and signaling. Confidence: Medium","confidence":"","size":24,"edges":11,"triangles":4,"max_degree":5,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0061370","count":8},{"id":"GO:0008209","count":8},{"id":"GO:0060137","count":7},{"id":"GO:0009822","count":7},{"id":"GO:0031408","count":7}]},{"hash":"1219893742280336899","title":"Neuromuscular junction assembly and Golgi-ER trafficking","description":"This cluster is enriched for terms related to synaptic assembly at the neuromuscular junction and Golgi/ER organization, including ER membrane fusion, pointing to a shared role in membrane trafficking essential for synapse formation.","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051260","count":19},{"id":"GO:0007030","count":14},{"id":"GO:0008582","count":13},{"id":"GO:0051124","count":13},{"id":"GO:0071158","count":13}]},{"hash":"295291570944562128","title":"Cell adhesion and neural development","description":"These proteins show strong enrichment for cell adhesion terms (heterophilic and homophilic cell-cell adhesion) and neural development (nervous system development, positive regulation of synapse assembly), with additional hints of synapse formation and smooth muscle proliferation. The dominant pattern centers on adhesion-guided interactions driving neural development and synapse assembly, making \"Cell adhesion and neural development\" a concise, representative label. The ossification term is ancillary within broad developmental contexts, not core to the cluster\u2019s primary signal.","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":14},{"id":"GO:0043931","count":12},{"id":"GO:0007156","count":11},{"id":"GO:0048661","count":10},{"id":"GO:0051965","count":10}]},{"hash":"54943186750261594","title":"Actin Dynamics and Apoptotic Stress Response","description":"This cluster is dominated by actin cytoskeleton remodeling signals (actin cortical patch assembly; regulation of Arp2/3-mediated nucleation) and apoptotic signaling (cysteine-type endopeptidase activation and apoptosis), with accompanying stress-growth cues (hypoxia response, mitotic cell cycle, proliferation regulation, and protein autophosphorylation). Together they point to a theme of cytoskeletal changes linked to cell fate decisions and stress responses.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006919","count":9},{"id":"GO:0000147","count":8},{"id":"GO:0034316","count":8},{"id":"GO:0043547","count":8},{"id":"GO:0071456","count":8}]},{"hash":"2235112576660332750","title":"Immune signaling and inflammatory response","description":"This cluster is enriched for inflammatory and immune-related signaling terms: inflammatory response, cellular response to lipopolysaccharide, response to muramyl dipeptide, and B cell receptor signaling, along with responses to growth factors and peptide hormones, indicating a general theme of immune activation and inflammation. A small portion relates to core protein synthesis but does not override the immune theme.","confidence":"Medium","size":24,"edges":24,"triangles":0,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0001403","count":3},{"id":"GO:0035994","count":2},{"id":"GO:0035729","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0071222","count":2}]},{"hash":"1775512338298840889","title":"Rho GTPase signaling in heart development and migration","description":"The top GO terms center on Rho-family GTPase activity regulation and phosphatidylinositol-mediated signaling, suggesting a core role in cytoskeletal dynamics and signaling. The presence of cardiac-related terms (cardiac muscle contraction, heart development) alongside migration/angiogenesis regulation (cell migration, sprouting angiogenesis) points to a cluster of proteins coordinating cytoskeleton remodeling, cell movement, and cardiac development. While some terms (e.g., acrosome reaction, mitotic cell cycle) may reflect broader signaling roles, the dominant theme appears to be Rho GTPase\u2013mediated signaling linked to heart development and cellular migration.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0048015","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0007340","count":3}]},{"hash":"1586969612151879488","title":"Meiosis: chromosome pairing and synaptonemal complex","description":"The GO terms are dominated by meiotic processes: homologous chromosome pairing, synaptonemal complex assembly, and meiotic joint molecule formation, indicating a cluster tied to meiotic chromosomal pairing and recombination. Additional terms related to DNA damage response (cisplatin/hydroxyurea) and apoptosis appear, but the central theme remains meiosis-related chromosomal dynamics and recombination machinery.","confidence":"High","size":24,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007129","count":3},{"id":"GO:0006486","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0030879","count":2},{"id":"GO:0007130","count":2}]},{"hash":"913927009201937402","title":"DNA transcription regulation and cell cycle factors","description":"The top GO terms cluster around regulation and execution of DNA-templated transcription, including regulation of transcription and development-related processes, along with cell cycle (mitotic) terms and ubiquitination, suggesting a set of nuclear regulatory proteins involved in gene expression control during development and cell cycle. Some transport-related terms appear but are likely peripheral to the main theme.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":4},{"id":"GO:0042391","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0070979","count":3}]},{"hash":"72610727811974200","title":"Mitochondrial translation and respiration","description":"The top GO terms point to mitochondrial-centric processes: translation, import into the mitochondrial matrix, assembly of the respiratory chain (complex III), electron transport with proton translocation, and aerobic respiration, with supporting roles from mitochondrial tRNA methylation and fatty acid oxidation. This coherence strongly suggests a mitochondria-focused energy-production cluster.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0034551","count":3},{"id":"GO:0030150","count":2},{"id":"GO:0009060","count":2},{"id":"GO:0006122","count":2}]},{"hash":"1841031069838811927","title":"B cell signaling and angiogenesis regulation","description":"The cluster shows strong signals for adaptive immune functions (adaptive immune response, follicular B cell differentiation, B cell receptor signaling) along with vascular regulatory terms (negative regulation of angiogenesis, positive regulation of endothelial cell migration), with additional signaling context (Rho/Ras pathways, IP3 biosynthesis). This points to a core theme of B cell\u2013mediated signaling intertwined with angiogenesis control.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0016525","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0032959","count":2},{"id":"GO:0030900","count":2}]},{"hash":"1742192216257092686","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":23,"triangles":0,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0007605","count":4},{"id":"GO:1903608","count":3},{"id":"GO:1990928","count":3},{"id":"GO:0072752","count":3}]},{"hash":"1637714154998979227","title":"Cardiac development and SA node signaling","description":"The cluster is dominated by GO terms tied to heart formation, secondary heart field development, Notch signaling in cardiac contexts, and pacemaker/conduction activities (SA node action potential regulation and SA node-to-atrial cell communication), suggesting genes involved in cardiac development and the heart's conduction system. Additional terms about cellular migration and mechanical stimulus may relate to tissue remodeling during heart formation. While a few terms touch on brain development or aging, the core pattern centers on cardiac development and pacemaker signaling.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0007568","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0044707","count":3}]},{"hash":"2171031013955804981","title":"Immune activation and cell-mediated responses","description":"The top GO terms are dominated by immune-related processes (positive regulation of monocyte chemotactic protein-1 production, complement activation, NK cell\u2013mediated cytotoxicity, and T cell proliferation), suggesting a shared role in immune signaling. Other terms such as odontogenesis, neurogenesis, and coagulation appear but are less represented, so the strongest theme is immune activation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071639","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0042475","count":2},{"id":"GO:0022008","count":2},{"id":"GO:0002860","count":2}]},{"hash":"1089384363282341497","title":"Vision and phototransduction signaling","description":"The top GO terms are strongly centered on vision-related processes (visual perception, visual learning, regulation of opsin-mediated signaling) and phototransduction signaling, with protein phosphorylation suggesting signaling cascades in photoreceptors; secondary terms related to temperature or pain appear less central.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0040015","count":13},{"id":"GO:0008542","count":13},{"id":"GO:0002024","count":12},{"id":"GO:0019233","count":12},{"id":"GO:0071502","count":12}]},{"hash":"1725539409704533431","title":"GPCR Signaling Regulation and Cardiovascular Tone","description":"This cluster is dominated by terms about regulation of GTPase activity and GPCR signaling, with downstream links to cardiovascular functions (vascular smooth muscle contraction, heart contraction modulation by adrenergic signals) and neural/immune outputs (dopamine/serotonin signaling, dendritic cell chemotaxis). The coherence around GPCR-driven signal transduction and its physiological effects across heart, vessels, and neural/immune contexts supports this label as representative of the cluster\u2019s function.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":22},{"id":"GO:0033861","count":21},{"id":"GO:0031649","count":21},{"id":"GO:2000420","count":21},{"id":"GO:0001997","count":21}]},{"hash":"434651928981268382","title":"Dopaminergic Synaptic and Cardiovascular GPCR Signaling","description":"The top GO terms are dominated by dopaminergic synaptic transmission and GPCR signaling, with repeated references to heart contraction, vascular smooth muscle contraction, and adrenergic/serotonin receptor pathways. This points to a cluster of proteins involved in neuromodulatory signaling that also modulates cardiovascular function via GPCR-mediated pathways.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001963","count":24},{"id":"GO:0033861","count":23},{"id":"GO:0031649","count":23},{"id":"GO:2000420","count":23},{"id":"GO:0001997","count":23}]},{"hash":"28804897741541839","title":"Neuronal ion transport and synaptic signaling","description":"The top GO terms point to ion transport across membranes (sodium, potassium, calcium), excitatory and GABAergic neurotransmission, and neural-driven behaviors (startle response, locomotion) as well as circadian regulation. This combination indicates a cluster of proteins involved in neuronal excitability, synaptic signaling, and behavior modulation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":12},{"id":"GO:0060079","count":10},{"id":"GO:0098703","count":9},{"id":"GO:0045188","count":9},{"id":"GO:0001964","count":9}]},{"hash":"1914289891969968572","title":"Vesicle trafficking and ECM regulation","description":"The top GO terms cluster around intracellular transport and processing via the secretory pathway (ER to Golgi vesicle transport, anterograde synaptic vesicle transport, protein import) and post-translational modification (protein ubiquitination), suggesting coordinated protein trafficking and processing. The terms related to regulation of integrin-mediated cell-cell adhesion and extracellular matrix disassembly imply downstream effects on cell\u2013matrix interactions. A couple of terms about nicotine catabolism and locomotory exploration appear peripheral to the main theme. Overall, the cluster centers on trafficking and ECM-related regulation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0071901","count":2},{"id":"GO:0048490","count":2},{"id":"GO:0071260","count":2}]},{"hash":"1223056029237993703","title":"Embryonic Development and Organogenesis","description":"The top GO terms indicate broad developmental processes: pancreatic cell development, trophoblast differentiation, epithelial-to-mesenchymal transition in heart formation, placenta-related differentiation, endocrine system development, left-right patterning, and cartilage morphogenesis. Together these point to a cohesive theme of embryonic development and tissue morphogenesis. Some RNA processing terms appear, likely reflecting general gene-expression needs during development, but the central signal is developmental differentiation and organogenesis.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0003323","count":12},{"id":"GO:0060707","count":12},{"id":"GO:0003198","count":12},{"id":"GO:0060806","count":12},{"id":"GO:0035270","count":12}]},{"hash":"2298929846740532991","title":"GTPase-Regulated Motility and Cytokinesis","description":"The cluster is enriched for small GTPase signaling and cytoskeletal processes (positive regulation of GTPase activity, small GTPase-mediated signaling, cell migration, cleavage furrow formation), suggesting proteins that coordinate signaling to the cytoskeleton and cell division. Some terms (spliceosome, development) are broader or outliers, but the dominant theme centers on GTPase-driven motility and cytokinesis.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0016477","count":2}]},{"hash":"1117561773359780417","title":"GPCR signaling in neurotransmission and vascular regulation","description":"This cluster centers on GPCR signaling and regulation, with several terms pointing to neurotransmitter pathways (serotonin and dopamine signaling) and cardiovascular/vascular responses (heart contraction modulation, vascular smooth muscle contraction). Dendritic cell chemotaxis adds an immune signaling aspect, suggesting a broader signaling module that links neural/hormonal signaling to vascular and immune processes. The assortment indicates a coherent theme of GPCR-mediated signal transduction affecting neurotransmission and vascular function rather than a structural complex.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":24},{"id":"GO:0031649","count":24},{"id":"GO:2000420","count":24},{"id":"GO:0001997","count":24},{"id":"GO:0045745","count":24}]},{"hash":"2275905227264310114","title":"GPCR Signaling Regulation in Cardiovascular and Immune Systems","description":"This cluster is dominated by GO terms centered on GPCR signaling and its regulation (e.g., positive regulation of GPCR signaling, serotonin receptor pathways), with downstream connections to GTPase activity, dopamine secretion, and dendritic cell chemotaxis. The presence of cardiovascular-related terms (adrenergic regulation of heart contraction, vascular smooth muscle contraction) alongside immune-neural processes suggests a common thread of GPCR-mediated signaling that influences neural, immune, and cardiovascular functions. Hence, a label highlighting GPCR signaling regulation across these systems is representative.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":22},{"id":"GO:0031649","count":22},{"id":"GO:2000420","count":22},{"id":"GO:0001997","count":22},{"id":"GO:0045745","count":22}]},{"hash":"1624319770304956353","title":"Embryonic morphogenesis and organogenesis","description":"These proteins are linked to a broad set of embryonic development processes across multiple tissues, including mesoderm formation, cartilage morphogenesis, left-right patterning, placenta and endocrine system development, and epithelial-to-mesenchymal transitions. The common thread is regulation of tissue formation and organogenesis during embryogenesis, with some entries indicating transcriptional control of differentiation. The cluster appears to represent developmental patterning and morphogenic events rather than a single tissue-type.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003323","count":9},{"id":"GO:0060021","count":9},{"id":"GO:0000122","count":9},{"id":"GO:0003198","count":8},{"id":"GO:0060536","count":8}]},{"hash":"553446002110169321","title":"Neural and vascular morphogenesis with Rho/JNK signaling","description":"This cluster combines terms for neural development (metencephalon development, cochlea morphogenesis, acetylcholine-gated channel clustering) with vascular morphogenesis (endothelial tube lumen extension, sprouting angiogenesis regulation) and cytoskeletal signaling (Rho/Rac, JNK, stress fiber assembly), suggesting a cohesive theme of morphogenesis governed by Rho/JNK pathways in neural and vascular contexts.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097498","count":4},{"id":"GO:0022037","count":3},{"id":"GO:0090103","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0043507","count":3}]},{"hash":"1512827863160685012","title":"Unknown","description":"The GO terms span immune signaling (NF-kappaB regulation, interferon-beta response), neuronal synapse processes (synaptic vesicle clustering, modulation of postsynaptic potentials), receptor internalization, development-related morphogenesis, vascular wound healing, zinc ion homeostasis, and cytolysis, with no clear shared function linking these proteins. This diversity suggests there is no cohesive theme for a meaningful specific label.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901223","count":3},{"id":"GO:0097091","count":2},{"id":"GO:0031623","count":2},{"id":"GO:1990522","count":2},{"id":"GO:0061042","count":2}]},{"hash":"307991882180691171","title":"Transcriptional Regulation and Protein Turnover","description":"This cluster is enriched for DNA-templated transcription, histone methylation, and ubiquitin-dependent degradation pathways, pointing to coordinated regulation of gene expression and proteostasis. There are additional signals of protein interactions and trafficking (protein homooligomerization, cilium assembly, peroxisome targeting), suggesting a broader regulatory network that links transcriptional control with protein turnover. Some terms are peripheral or deprecated, but the dominant theme is transcriptional regulation coupled with proteostasis.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":13},{"id":"GO:0051260","count":13},{"id":"GO:0030433","count":12},{"id":"GO:0051568","count":12},{"id":"GO:0034729","count":12}]},{"hash":"1706699714365564734","title":"Neurodevelopment and neural differentiation","description":"This cluster is enriched for neural development and cell fate specification terms (spinal cord motor neuron and oligodendrocyte fate, interneuron differentiation, neuroblast fate, neural retina development) and general transcription by RNA polymerase II, suggesting a cohesive group of proteins involved in neural differentiation programs. Some terms touch on development in other tissues (bronchiole, pancreas, skeletal muscle), which may reflect broader developmental regulation rather than a strictly neural module.","confidence":"High","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":23},{"id":"GO:0021520","count":23},{"id":"GO:0021530","count":23},{"id":"GO:0031018","count":23},{"id":"GO:0060163","count":23}]},{"hash":"1961854830862587174","title":"Embryonic organogenesis and tissue morphogenesis","description":"Reasoning: The top terms cluster around embryonic development and organ morphogenesis across several tissues (digestive tract, ureteric bud branching, neural crest migration, endocrine pancreas development, lens proliferation) and include regulatory processes (transcriptional regulation, Wnt signaling). This pattern points to a broad developmental program governing organ formation rather than a single pathway.","confidence":"High","size":23,"edges":138,"triangles":379,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":17},{"id":"GO:0048557","count":16},{"id":"GO:0090190","count":16},{"id":"GO:0001755","count":16},{"id":"GO:0031018","count":16}]},{"hash":"1569686211925923070","title":"Neurodevelopmental and morphogenesis regulators","description":"This cluster centers on developmental regulation with neural differentiation signals (neural retina development, neuroblast fate, noradrenergic neuron fate), timing via circadian entrainment, and various tissue morphogenesis programs (skeletal muscle, sinus venosus, seminal vesicle). The mixture suggests a module of transcriptional regulators guiding multi-tissue development and timing rather than a single tissue process.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":20},{"id":"GO:2001038","count":18},{"id":"GO:0048712","count":18},{"id":"GO:0007400","count":17},{"id":"GO:0048743","count":17}]},{"hash":"88630768046847286","title":"Developmental transcription regulation and chromatin remodeling","description":"This cluster centers on GO terms for RNA polymerase II\u2013mediated transcription and chromatin remodeling, indicating core gene regulation. The presence of development-specific terms (pancreas development, digestive tract morphogenesis, neural crest migration, ureteric branching) suggests these regulators act during organogenesis and morphogenesis, making this label appropriate.","confidence":"High","size":23,"edges":153,"triangles":402,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0006351","count":9},{"id":"GO:0071353","count":8},{"id":"GO:0006366","count":8},{"id":"GO:0031018","count":7}]},{"hash":"233027815998872761","title":"Vertebrate Developmental Signaling and Stress Response","description":"The cluster\u2019s top GO terms include vertebrate tissue development (lung mesenchyme development, Schwann cell development, tricuspid valve morphogenesis) and signaling (MAPK cascade) together with apoptosis and stress responses (apoptotic process, response to toxic substance). Vitamin D3 metabolism ties into vertebrate development, while some terms like sorbitol response and abscisic acid signaling may reflect general stress signaling or noise. Taken together, these terms point to a cohesive theme of development-associated signaling and stress response.","confidence":"Medium","size":23,"edges":252,"triangles":1750,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070640","count":23},{"id":"GO:0072709","count":23},{"id":"GO:0000196","count":23},{"id":"GO:0060484","count":23},{"id":"GO:0006915","count":23}]},{"hash":"1653597501336010989","title":"UPR-Linked Transcriptional Regulation","description":"The cluster centers on transcription control by RNA polymerase II and DNA-templated transcription, coupled with PERK-mediated unfolded protein response, suggesting proteins co-function in regulating gene expression under ER stress. Tissue development terms (pituitary, retina, pancreatic cell differentiation) may reflect contexts where this transcriptional program operates, but the common thread is transcriptional regulation tied to ER stress/UPR.","confidence":"High","size":23,"edges":250,"triangles":1711,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":12},{"id":"GO:0006366","count":10},{"id":"GO:0036499","count":10},{"id":"GO:0021983","count":9},{"id":"GO:0060041","count":9}]},{"hash":"1167699762242502600","title":"Neural and sensory organ development with transcriptional regulation","description":"The top GO terms indicate neural and sensory organ development (brain segmentation, eye and inner ear development, pituitary and hypothalamus differentiation, motor neuron axon guidance) and transcriptional control by RNA polymerase II, including negative regulation. This together suggests a cluster of proteins coordinating neural/sensory development via transcriptional regulation.","confidence":"High","size":23,"edges":18,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0006366","count":9},{"id":"GO:0008045","count":8},{"id":"GO:0043010","count":7},{"id":"GO:0021979","count":7}]},{"hash":"1804412222666884696","title":"Vertebrate development and regeneration","description":"This cluster centers on GO terms about development across multiple vertebrate tissues (inner ear, brain, skeletal muscle) and regeneration (fin regeneration, locomotory behavior). The inclusion of coagulation-related terms and Golgi localization may reflect broader cellular remodeling and trafficking processes that accompany development. Overall, the proteins appear to participate in vertebrate tissue development and regenerative responses rather than a single, tight pathway.","confidence":"Medium","size":23,"edges":27,"triangles":0,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":4},{"id":"GO:0032091","count":3},{"id":"GO:0048839","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0007519","count":2}]},{"hash":"110174918281302336","title":"Vesicle trafficking and membrane localization in cell movement","description":"The cluster is dominated by terms related to moving proteins to the plasma membrane (positive regulation of localization), vesicle docking and exocytosis, and specialized cargo transport (melanosomes). Additional terms point to cell migration and wound healing, and neuronal migration, all of which fit a common theme of vesicle-mediated trafficking and membrane localization driving cell movement and signaling. Some immune and metabolic terms may reflect broader cellular states but do not override the vesicle/membrane theme.","confidence":"Medium","size":23,"edges":12,"triangles":1,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903078","count":23},{"id":"GO:0042832","count":23},{"id":"GO:0008283","count":23},{"id":"GO:1903395","count":23},{"id":"GO:0006904","count":23}]},{"hash":"952657930122400947","title":"Adaptive immune activation and phagocytosis","description":"The top GO terms center on T cell costimulation, B cell activation and signaling, phagocytosis and its recognition, innate immune response, and complement activation. This points to a cluster of proteins coordinating adaptive immune activation with phagocytic and innate effector processes, rather than a single isolated pathway.","confidence":"High","size":23,"edges":75,"triangles":60,"max_degree":16,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0031295","count":11},{"id":"GO:0006911","count":11},{"id":"GO:0045087","count":11},{"id":"GO:0050871","count":11},{"id":"GO:0050853","count":11}]},{"hash":"1909250237310801400","title":"Neural and tissue development with apoptosis regulation","description":"The top GO terms point to development-related processes across neural and epithelial (hair follicle) tissues (brain development, hair follicle morphogenesis), coupled with mechanisms that govern cell turnover and survival (apoptotic regulation in hepatocytes and neurons) and basic cellular maintenance (endocytosis, mitochondrial assembly). While diverse, these terms collectively suggest a theme of development and tissue homeostasis with regulated cell death and basic cellular processes, justifying a label around neural and tissue development with apoptosis regulation.","confidence":"Medium","size":23,"edges":51,"triangles":40,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0071260","count":7},{"id":"GO:0006897","count":6},{"id":"GO:0097284","count":6},{"id":"GO:0031069","count":6},{"id":"GO:0048873","count":6}]},{"hash":"1092892127050436892","title":"Mechanotransduction and ECM remodeling","description":"Most prominent themes are extracellular matrix organization and mechanotransduction, with collagen fibril organization and cellular response to mechanical stimulus dominating. The presence of negative regulation of endothelial cell migration and VEGF signaling, along with bone resorption regulation, suggests coordinated remodeling of vasculature and bone in response to mechanical cues. Axonogenesis and dendritic cell cytokine regulation indicate broader tissue remodeling and cross-talk in mechanically active environments. Overall, the cluster seems to represent mechanotransduction-linked ECM remodeling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":7},{"id":"GO:0030199","count":7},{"id":"GO:0010596","count":6},{"id":"GO:0014068","count":6},{"id":"GO:0007409","count":6}]},{"hash":"1963347145373566545","title":"ER Protein Folding and Quality Control","description":"The cluster\u2019s top GO terms cluster tightly around endoplasmic reticulum functions: protein folding in the ER, misfolded protein transport, ubiquitin-dependent ERAD, and regulation of translation and protein export during ER stress. While a couple terms (DNA replication, tRNA import into the nucleus) are less directly ER-related, the prevailing theme is ER quality control and protein homeostasis, including handling misfolded proteins and ER stress responses.","confidence":"Medium","size":23,"edges":40,"triangles":3,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0035719","count":3},{"id":"GO:1900035","count":3},{"id":"GO:0070843","count":3},{"id":"GO:0034975","count":3}]},{"hash":"1462205362084342113","title":"Calcium-driven cardiovascular signaling and contraction","description":"This cluster\u2019s top GO terms cluster around calcium release into the cytosol, GPCR signaling, and contraction-related processes in the heart and vascular smooth muscle. The dominant pattern points to calcium- and GPCR-mediated signaling that regulates cardiovascular function, with GTPase activity and heat generation as related signaling aspects. Some terms (retina development, eosinophil regulation) appear as less connected outliers, but the core theme is calcium-dependent signaling leading to cardiovascular contraction.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":22},{"id":"GO:0043547","count":22},{"id":"GO:0008283","count":22},{"id":"GO:0060041","count":22},{"id":"GO:0033861","count":21}]},{"hash":"648344112508602333","title":"Translation Initiation and mRNA Processing","description":"These proteins cluster around core processes of translation initiation and reinitiation (translation reinitiation, preinitiation complex formation, regulation of translational initiation) and viral translation control (IRES-dependent initiation, termination-reinitiation), with accompanying RNA processing/export activities (mRNA export, splicing, poly(A) tail regulation). The shared theme is RNA metabolism linked to initiation of translation, including viral mechanisms, suggesting a coherent translation-related RNA processing module.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":11},{"id":"GO:0001731","count":11},{"id":"GO:0006446","count":10},{"id":"GO:0075525","count":10},{"id":"GO:0075522","count":10}]},{"hash":"833823926115429313","title":"Embryonic development and morphogenesis","description":"This cluster is dominated by GO terms tied to embryonic development across multiple tissues, especially craniofacial/palatal (roof of mouth development), mesoderm-derived structures (cartilage morphogenesis, mesoderm development, left-right pattern formation), and heart/placental lineages (endocardial cushion formation, trophoblast/placental development, endocrine system development). The convergence on diverse developmental processes rather than a single pathway suggests a broad embryogenesis theme. Confidence: High","confidence":"","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":19},{"id":"GO:0000122","count":16},{"id":"GO:0003198","count":15},{"id":"GO:0060536","count":15},{"id":"GO:0060972","count":15}]},{"hash":"565074424116413701","title":"Axon development and signaling regulation","description":"The top terms cluster around regulation of axonogenesis/axon extension, ephrin receptor signaling, and focal adhesion assembly, with supporting signals from JNK cascade regulation and protein stability. Although some immune-related terms appear, the dominant pattern points to control of neuronal development and associated signaling pathways that govern axon guidance and cell adhesion.","confidence":"Medium","size":23,"edges":20,"triangles":1,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046330","count":21},{"id":"GO:0000278","count":21},{"id":"GO:0043304","count":20},{"id":"GO:0051893","count":20},{"id":"GO:0031647","count":20}]},{"hash":"453355154545353521","title":"Platelet and leukocyte activation signaling","description":"This cluster is dominated by GO terms related to activation and signaling of platelets and immune cells (positive regulation of platelet activation; leukocyte tethering/rolling; basophil activation; Fc-gamma receptor signaling; NK cell chemotaxis regulation), indicating a cohesive theme of platelet\u2013immune cell activation and adhesion. A few developmental terms (mesonephric duct and metanephric morphogenesis) may reflect shared gene modules with other tissues, but the strongest signal still points to immune- and platelet-mediated signaling networks.","confidence":"High","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":23},{"id":"GO:0072177","count":23},{"id":"GO:0072287","count":23},{"id":"GO:0036303","count":23},{"id":"GO:0090403","count":23}]},{"hash":"1582627461817886807","title":"RNA splicing and translation regulation","description":"The cluster is enriched for RNA processing and translation-related terms: spliceosome-mediated mRNA splicing (cis and alternative), mRNA export from the nucleus, formation of the translation preinitiation complex, regulation of translational initiation, and translation reinitiation, indicating a module tying RNA maturation to protein synthesis; occasional terms like mitotic cell cycle and blastocyst formation appear but are less central to the core theme.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0006406","count":6},{"id":"GO:0001731","count":6},{"id":"GO:0006446","count":5},{"id":"GO:0001825","count":5}]},{"hash":"1076435800457664769","title":"Developmental Signaling Pathways","description":"This cluster centers on multiple signaling pathways (Hedgehog via Smoothened, ROBO/Roundabout, ERK/MAPK) and development-related processes (nervous system and kidney development, axonogenesis), with additional links to cell cycle and T cell receptor signaling, pointing to a broad theme of signaling controlling development and cellular behavior across tissues.","confidence":"Medium","size":23,"edges":110,"triangles":132,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033138","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0001822","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0050771","count":4}]},{"hash":"474367626183617332","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":16,"triangles":1,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":4},{"id":"GO:0015937","count":3},{"id":"GO:0006189","count":3},{"id":"GO:0071897","count":3},{"id":"GO:0006223","count":2}]},{"hash":"2026243284820351677","title":"Wnt-regulated development and transcription","description":"This cluster shows strong representation of Wnt signaling, neural development (midbrain/forebrain), and skeletal development, along with GO terms for DNA-templated transcription and its negative regulation. The combination points to proteins involved in transcriptional control during developmental signaling, with Wnt as a central regulator. A few terms (defense response to Gram-positive bacteria, single fertilization) are less consistent but do not override the core pattern.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0007338","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0035264","count":5},{"id":"GO:0050830","count":5}]},{"hash":"598903321202589601","title":"Immune signaling and tissue remodeling","description":"The cluster centers on innate immune signaling (type I interferon pathway, NK cell cytotoxicity, complement activation, LPS response) and signaling related to cell-matrix adhesion (integrin signaling, cell-matrix adhesion, ERK cascade) with links to angiogenesis and developmental growth, suggesting a theme of immune activation coupled to tissue remodeling.","confidence":"High","size":23,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060337","count":9},{"id":"GO:0042267","count":9},{"id":"GO:0045766","count":8},{"id":"GO:0007229","count":8},{"id":"GO:0001867","count":8}]},{"hash":"1261535808398137563","title":"Arabinogalactan Proteins and Plant Cell Wall Glycosylation","description":"The cluster is dominated by GO terms pointing to arabinogalactan proteins (arabinogalactan protein metabolic process, AGP glycosylation) and related polysaccharide biosynthesis, including seed coat mucilage and root hair development. These are classic plant cell wall glycoproteins whose glycosylation and metabolism underpin root hair formation, seed mucilage, and cell wall structure, suggesting the proteins function together as AGP-related cell wall components. The terms collectively form a coherent plant-specific glycoprotein/glycosylation theme, despite a few outliers. ","confidence":"High","size":23,"edges":161,"triangles":472,"max_degree":19,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0006486","count":3},{"id":"GO:0030311","count":3},{"id":"GO:0042248","count":3},{"id":"GO:0001744","count":3}]},{"hash":"1928420102805239912","title":"Neural signaling and locomotion behaviors","description":"This cluster centers on signaling pathways (GPCR signaling, Rho signaling, and related regulators) and behavioral outputs, including locomotory behavior, peristalsis, visual perception, and pain perception. The mix of terms suggests proteins involved in neural communication and motor/sensory responses, with some metabolic terms likely reflecting neuronal energy demands rather than a single metabolic pathway. Overall, the theme is neural signaling driving movement and sensory processing.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0010579","count":14},{"id":"GO:0035025","count":14},{"id":"GO:0007626","count":12}]},{"hash":"434128332512454124","title":"Ribosome Biogenesis and Translation","description":"The terms are strongly dominated by translation (GO:0006412) and ribosomal large subunit biogenesis/assembly, indicating proteins involved in ribosome construction and protein synthesis. While some transcription-related GO terms appear, they are much less frequent, so the core theme is ribosome biogenesis and translation machinery.","confidence":"High","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":19},{"id":"GO:0000027","count":5},{"id":"GO:0042273","count":5},{"id":"GO:0006353","count":4},{"id":"GO:0031564","count":4}]},{"hash":"839418065205689795","title":"Unknown","description":"The top GO terms span cell cycle, ER targeting, cardiac action potential regulation, NF-kappaB signaling, viral-host interactions, and nucleus organization, with little overlap. There isn\u2019t a single cohesive biological theme tying these functions together, so a specific, confident label would be speculative.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":4},{"id":"GO:0006620","count":3},{"id":"GO:0098907","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0098910","count":3}]},{"hash":"1598866090941767273","title":"Developmental signaling and cytoskeletal regulation","description":"This cluster centers on signaling pathways that control development and synaptic/cytoskeletal dynamics (brain development, synapse plasticity, Wnt signaling) and includes roles in cytoskeletal polarity and mitosis, suggesting a module of regulators coordinating signaling cues with cytoskeletal remodeling and cell proliferation across contexts, even though an immune signaling term is present.","confidence":"Medium","size":23,"edges":19,"triangles":6,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0030950","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0071806","count":5}]},{"hash":"283855946269580393","title":"Cell cycle control and developmental signaling","description":"The Top Terms include strong signals for regulation of the cell cycle and mitosis (regulation of cell cycle, mitotic cytokinesis) as well as regulators of GTPase activity and nuclear import, along with several development-related processes (oocyte localization, renal vesicle formation, EMT regulation, Wnt signaling). This suggests a cluster of proteins that coordinate cell division with developmental signaling during organogenesis and oogenesis, rather than a single tightly focused pathway. Therefore a label that reflects both cell cycle control and developmental signaling is appropriate.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":10},{"id":"GO:0043547","count":10},{"id":"GO:0015991","count":10},{"id":"GO:0006607","count":10},{"id":"GO:0030720","count":9}]},{"hash":"2136966623194748483","title":"Platelet activation and megakaryocyte development","description":"The cluster\u2019s GO terms cluster around platelet biology and megakaryocytes: blood coagulation, megakaryocyte development, and positive regulation of platelet activation, supported by microtubule-based movement and cell migration that reflect cytoskeletal remodeling during platelet formation. While a few metabolic terms appear, they are less central to the main theme. Overall, the dominant signal points to platelet formation and function.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0045725","count":3},{"id":"GO:0010765","count":3},{"id":"GO:0007018","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0035855","count":3}]},{"hash":"1437970280427245660","title":"Ribosome Biogenesis and Translation Machinery","description":"Strong emphasis on ribosome biogenesis, cytoplasmic translation, tRNA transcription, and rRNA maturation indicates a core link to ribosome assembly and protein synthesis. Some immune/viral transcription terms are present but the dominant theme is ribosome biogenesis and translation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":6},{"id":"GO:0002181","count":3},{"id":"GO:0042797","count":3},{"id":"GO:0046782","count":2},{"id":"GO:0045087","count":2}]},{"hash":"2060249621141522263","title":"Ribosome Biogenesis and Translation Initiation","description":"This cluster centers on ribosome assembly and function, with GO terms for ribosome biogenesis (including large subunit), rRNA maturation, export of the large subunit, and multiple aspects of translation initiation (preinitiation complex formation, translation reinitiation, and regulation). The shared theme is proteins involved in ribosome biogenesis and the initiation of translation.","confidence":"High","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":6},{"id":"GO:0042273","count":5},{"id":"GO:0000055","count":5},{"id":"GO:0000462","count":4},{"id":"GO:0043547","count":4}]},{"hash":"792435868785341034","title":"Immunological synapse and lymphocyte activation","description":"The terms cluster around cell-cell adhesion (both heterophilic and homophilic), T cell costimulation, regulation of NK cell cytotoxicity, cytokine production (IL-4), and regulation of synapse assembly, all pointing to lymphocyte communication and activation at the immunological synapse. Terms about virion/symbiont interactions reflect host\u2013pathogen engagement at the cell interface but still fit within immune cell signaling and adhesion contexts. This cohesive theme supports a label focused on immunological synapse formation and lymphocyte activation.","confidence":"High","size":23,"edges":205,"triangles":953,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":10},{"id":"GO:0031295","count":9},{"id":"GO:0046718","count":9},{"id":"GO:0043031","count":9},{"id":"GO:0007156","count":9}]},{"hash":"1521294159869043203","title":"GPCR-Mediated Cardiovascular and Immune Signaling","description":"The Top Terms point to regulation of GPCR pathways, membrane potential, and GTPase activity, together with cardiovascular-related processes like heart contraction and vascular smooth muscle contraction, plus immune cell movement such as dendritic cell chemotaxis. This pattern suggests a cohesive module of GPCR-driven signaling that modulates both cardiovascular function and immune cell behavior, with membrane potential changes as a common mechanism. Hence a label emphasizing GPCR signaling with cardio-vascular and immune system relevance.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042391","count":22},{"id":"GO:0033861","count":21},{"id":"GO:0031649","count":21},{"id":"GO:2000420","count":21},{"id":"GO:0001997","count":21}]},{"hash":"1740662710619721185","title":"Adrenergic GPCR-cAMP Cardiac Signaling","description":"Based on the top GO terms, the cluster is dominated by adrenergic GPCR activation leading to adenylate cyclase activation and cAMP signaling, which regulate heart contraction strength and blood pressure (GO:0045777, GO:0022900, GO:0007190, GO:0001997). The inclusion of Rho signaling and cytoskeletal regulation (GO:0035025) alongside energy-related processes (electron transport chain, heat generation) suggests downstream metabolic and contractile support typical of cardiovascular signaling. Saliva secretion may reflect broader autonomic regulation. Overall, the terms converge on autonomic/cardiovascular signaling with energy metabolism, supporting the proposed label.","confidence":"High","size":23,"edges":4,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":19},{"id":"GO:0022900","count":19},{"id":"GO:0010579","count":19},{"id":"GO:0046541","count":17},{"id":"GO:0007190","count":17}]},{"hash":"510912729336213429","title":"GPCR Signaling in Cardiovascular and Immune Regulation","description":"The top GO terms cluster around G protein-coupled receptor signaling and downstream cardiovascular and immune processes, including regulation of heart contraction by catecholamines, vascular smooth muscle contraction, serotonin receptor signaling, dopamine secretion, and dendritic cell chemotaxis. This suggests a cohesive module centered on GPCR-mediated signaling affecting cardiovascular, neuroendocrine, and immune functions, despite the lack of observed protein interactions in this dataset.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":23},{"id":"GO:0031649","count":23},{"id":"GO:2000420","count":23},{"id":"GO:0001997","count":23},{"id":"GO:0045745","count":23}]},{"hash":"2088495438671622398","title":"GPCR-Driven Cardiovascular and Neural Signaling","description":"This cluster's top GO terms emphasize GPCR signaling and its regulation, including serotonin/dopamine signaling and pathways that control heart contraction, vascular smooth muscle activity, and related neural-immune processes. The common thread is GPCR-mediated signaling influencing cardiovascular and neural-immune contexts, justifying a label focused on GPCR-driven signaling in these systems.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":23},{"id":"GO:0031649","count":23},{"id":"GO:2000420","count":23},{"id":"GO:0001997","count":23},{"id":"GO:0045745","count":23}]},{"hash":"1287158385976344782","title":"Unknown","description":"The terms show a mix of vision and pain perception, neural/behavioral responses, and other disparate processes like saliva secretion, heart development, and metabolism, with no single cohesive function tying all proteins together. Therefore no coherent, representative label can be confidently assigned.","confidence":"","size":23,"edges":59,"triangles":18,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":17},{"id":"GO:0046541","count":17},{"id":"GO:0071380","count":16},{"id":"GO:0002035","count":16},{"id":"GO:0008542","count":16}]},{"hash":"1831648831169220163","title":"Cardiac development and SA node signaling","description":"The top terms include heart-specific processes: Notch signaling in regulation of secondary heart field cardioblast proliferation, SA node cell action potential regulation, and SA node cell communication with atrial cardiac muscle cells, pointing to cardiac development and electrical conduction; other terms are more general cellular processes, but the cardiac signals predominate in this cluster.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0016477","count":6},{"id":"GO:0033028","count":6},{"id":"GO:0097284","count":6},{"id":"GO:0006397","count":6},{"id":"GO:0090162","count":6}]},{"hash":"1239436403967588110","title":"Osteogenesis and Integrin-Mediated Cell Adhesion","description":"This cluster centers on bone formation and osteoblast biology, with strong enrichment for ossification, osteoblast proliferation, and bone maturation, plus cell adhesion via integrins and ERK signaling. These themes suggest a cohesive role in osteogenesis supported by cell\u2013matrix adhesion and developmental signaling, despite some unrelated developmental terms appearing. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":17},{"id":"GO:0043931","count":12},{"id":"GO:0007275","count":11},{"id":"GO:0032516","count":11},{"id":"GO:0033690","count":10}]},{"hash":"871307406135519419","title":"Unknown","description":"Top terms span a mix of biosynthetic processes (antibiotic, menaquinone, biotin, urate) along with xenobiotic response and RNA capping, but there is no evident shared pathway or functional link among the proteins (no edges or triangles). This suggests the cluster lacks a cohesive functional theme.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":4},{"id":"GO:0009234","count":3},{"id":"GO:0034418","count":3},{"id":"GO:0046272","count":3},{"id":"GO:0046839","count":3}]},{"hash":"937899133814204288","title":"Adrenergic cardiovascular signaling and blood pressure regulation","description":"Top GO terms indicate positive regulation of blood pressure, heart contraction force via epinephrine/norepinephrine, vascular smooth muscle contraction, and GPCR signaling, all pointing to adrenergic control of cardiovascular function. Additional terms touch on Rho signaling and metabolic processes, which align with the cytoskeletal and energy demands of heart and vessel tissues. Overall, the cluster appears to group proteins involved in adrenergic GPCR pathways that regulate cardiovascular function and blood pressure.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":23},{"id":"GO:0022900","count":23},{"id":"GO:0010579","count":23},{"id":"GO:0035025","count":23},{"id":"GO:0033861","count":22}]},{"hash":"527856204574468873","title":"Transcription Regulation & RNA Processing in Development","description":"These proteins are enriched for core gene-expression processes (mRNA processing, RNA splicing, nucleosome assembly, and transcription by RNA polymerase II) and show signals for differentiation into epidermal and neural lineages (epidermis development, keratinocyte migration, astrocyte development). This points to a functional cluster centered on regulating transcription and RNA processing during developmental differentiation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0006397","count":4},{"id":"GO:0030154","count":4},{"id":"GO:0008544","count":3},{"id":"GO:0008380","count":3},{"id":"GO:0006334","count":3}]},{"hash":"764054735770568520","title":"Kidney development and angiogenesis","description":"The top GO terms show clear enrichment for kidney development and angiogenesis, suggesting these proteins participate in organ and vascular formation. Supporting terms point to transcriptional regulation (DNA-templated transcription), signaling (TGF-beta, NF-kappaB pathways), and related processes like mRNA splicing and actin dynamics, which are commonly involved in development and remodeling. Some unrelated terms (innate immunity, nutrient response) may reflect multifunctionality but do not override the central developmental theme. Overall, the cluster appears to reflect developmental signaling coordinating kidney and vascular formation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001822","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0007584","count":3}]},{"hash":"482512788771935753","title":"Neural development and axon guidance","description":"The GO terms are dominated by neural development and morphogenesis signals (retinal ganglion cell axon guidance, branching morphogenesis of a nerve, ephrin receptor signaling, integrin-regulated adhesion), with additional embryonic morphogenesis terms (notochord formation, nephric duct morphogenesis) and signaling pathways that can influence development. This suggests a cluster centered on neural development tied to broader morphogenetic processes.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":2},{"id":"GO:0072178","count":2},{"id":"GO:0014028","count":2},{"id":"GO:0071372","count":2},{"id":"GO:0031290","count":2}]},{"hash":"1466426781684593087","title":"Mechanotransduction and stress-response signaling","description":"The Top Terms cluster around sensing mechanical cues (muscle stretch, touch) and coordinating transcriptional/regulatory responses (DNA-templated transcription, NF-kappaB-related regulation, nuclear export). It also includes stress and immune-related pathways (mitophagy, NOD2 signaling, CXCL1 production) that often accompany mechanosensitive signaling. The combination suggests a module of proteins involved in mechanotransduction coupled to transcriptional and signaling responses, with potential links to cardiac tissue function (SA node regulation). Confidence: Medium","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0061734","count":2},{"id":"GO:0035994","count":2},{"id":"GO:1902083","count":2},{"id":"GO:0050976","count":2}]},{"hash":"1422573508882775003","title":"Immune receptor signaling and angiogenesis","description":"The cluster shows strong enrichment for B cell and T cell receptor signaling, VEGF receptor signaling, and angiogenesis, plus related serine/threonine kinase signaling and NF-kappaB regulation. This points to a shared function in immune-vascular signaling and inflammatory pathways. Some terms (corpus callosum development, pollen recognition) are less clearly connected and may reflect annotation noise, but the dominant terms support the immune-vascular theme.","confidence":"Medium","size":22,"edges":97,"triangles":210,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051092","count":21},{"id":"GO:0048010","count":21},{"id":"GO:0050853","count":21},{"id":"GO:0001525","count":21},{"id":"GO:0033138","count":21}]},{"hash":"1873553873175371738","title":"Eye and retina morphogenesis","description":"The cluster is strongly enriched for eye-related terms (camera-type eye development, retina development, embryonic eye morphogenesis) and also includes transcriptional regulation by RNA polymerase II, suggesting coordinated transcription factors drive eye/retina formation. While other developmental processes appear, the dominant and cohesive signal centers on eye/retina morphogenesis. ","confidence":"High","size":22,"edges":74,"triangles":42,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":14},{"id":"GO:0021983","count":12},{"id":"GO:0043010","count":12},{"id":"GO:0002087","count":12},{"id":"GO:0060441","count":12}]},{"hash":"2170501720951841426","title":"Mitochondrial Metabolite Transport & Insulin Response","description":"This cluster is dominated by GO terms for mitochondrial metabolite transport (citrate, CoA, pyridoxal phosphate, ornithine, manganese) and mitochondrial membrane dynamics, along with cellular responses related to insulin stimulus and glucose-regulated insulin secretion. The shared function appears to be mitochondrial carrier proteins that shuttle metabolites across membranes, linking mitochondrial metabolism with insulin signaling and energy regulation.","confidence":"High","size":22,"edges":34,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":6},{"id":"GO:0006828","count":5},{"id":"GO:0031921","count":5},{"id":"GO:0006843","count":5},{"id":"GO:0090149","count":5}]},{"hash":"1952771862461876853","title":"Neurovascular morphogenesis and axon guidance","description":"The top GO terms show both neural development (axon extension/guidance, paranodal junctions, retina layer formation, synaptic vesicle endocytosis) and vascular morphogenesis (endothelial chemotaxis, coronary artery morphogenesis, smooth muscle migration). This pattern suggests a cluster of proteins coordinating neurovascular development, especially at neural-vascular interfaces like the retina.","confidence":"High","size":22,"edges":84,"triangles":95,"max_degree":16,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0014909","count":12},{"id":"GO:0048842","count":12},{"id":"GO:0060982","count":12},{"id":"GO:0035767","count":11},{"id":"GO:0048846","count":11}]},{"hash":"1740362868017165308","title":"Neurite outgrowth and actin remodeling","description":"The top GO terms cluster around regulation of actin-based protrusions (filopodium and lamellipodium assembly), dendrite extension, and neurite sprouting, indicating proteins coordinating actin dynamics to promote neuronal process outgrowth; other terms also reflect broader cytoskeletal remodeling and membrane dynamics during development.","confidence":"High","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0051491","count":6},{"id":"GO:0051016","count":6},{"id":"GO:0010592","count":6},{"id":"GO:0001757","count":6},{"id":"GO:0051497","count":6}]},{"hash":"55471180196126445","title":"Neural development and Ca2+-mediated signaling","description":"This cluster centers on neural development, synaptic plasticity, and calcium-driven signaling. Terms such as short-term memory, regulation of neuronal synaptic plasticity, axonogenesis, astrocyte activation, and myelination in peripheral nervous system highlight neural development and communication, while detection of calcium and calcium-modulated pathways (including Wnt calcium signaling and calcium-regulated kinase activity) point to Ca2+-dependent signaling networks underpinning these processes.","confidence":"High","size":22,"edges":34,"triangles":13,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":12},{"id":"GO:0007223","count":12},{"id":"GO:0007614","count":11},{"id":"GO:0043547","count":11},{"id":"GO:0010881","count":11}]},{"hash":"1275691436401072782","title":"Male germline development and chromatin remodeling","description":"This cluster is enriched for GO terms tied to male reproductive development, specifically seminiferous tubule development and male gonad development, plus chromatin-related processes (histone acetylation/methylation) and transcription regulation. The combination suggests a module involved in germ cell differentiation with chromatin remodeling and coordinated gene expression; ribosome biogenesis and apoptotic signaling may reflect housekeeping and quality control during development.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0097190","count":5},{"id":"GO:0072520","count":5},{"id":"GO:0043981","count":5},{"id":"GO:0043982","count":5},{"id":"GO:0043966","count":5}]},{"hash":"1785922124555532612","title":"mRNA Splicing and Processing","description":"This cluster is dominated by GO terms tied to splicing (spliceosome, alternative splicing), together with mRNA export, polyadenylation, and mRNA modification/regulation. The frequent co-occurrence of spliceosome-mediated processes and mRNA maturation steps suggests a cohesive module of post-transcriptional regulation, likely comprised of splicing factors and regulators that coordinate transcript maturation and export.","confidence":"High","size":22,"edges":229,"triangles":1500,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":16},{"id":"GO:0031047","count":16},{"id":"GO:0006378","count":12},{"id":"GO:0045292","count":11},{"id":"GO:0006406","count":10}]},{"hash":"644970223688715121","title":"Developmental gene expression regulation","description":"The cluster shows enrichment for transcription by RNA polymerase II, its negative regulation, histone H3 acetylation, and ribosome biogenesis, alongside multiple development-related terms (forebrain and brain development, retina development, male gonad development, multicellular organism development, single fertilization). This suggests a cohesive theme around how gene expression is regulated during development across tissues, rather than a single narrow pathway.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0043966","count":4},{"id":"GO:0030900","count":3},{"id":"GO:0006366","count":3},{"id":"GO:0000122","count":3}]},{"hash":"2023881938541622021","title":"Developmental transcriptional regulation and retinoic acid signaling","description":"This cluster centers on transcriptional control during development, with strong representation of DNA-templated transcription and its regulation, and is enriched for diverse tissue development terms (heart, mammary gland, Leydig cells, vagina, fat). The presence of cellular response to retinoic acid and the p38 MAPK cascade suggests RA signaling modulates transcriptional programs across these developmental contexts, making the theme a coherent developmental gene-regulation module driven by RA signaling.","confidence":"High","size":22,"edges":34,"triangles":11,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":12},{"id":"GO:0060749","count":9},{"id":"GO:0033327","count":9},{"id":"GO:0006355","count":9},{"id":"GO:0060068","count":8}]},{"hash":"1099146913985891787","title":"DNA Replication and Chromatin Maintenance","description":"This cluster is dominated by GO terms for DNA replication, DNA biosynthetic process, DNA recombination, and CENP-A containing chromatin assembly, plus UV-damage repair, indicating a cohesive set of proteins involved in genome replication and chromatin maintenance. While some developmental terms appear (brain, spermatid development), they likely reflect broader chromatin-associated roles in different tissues.","confidence":"High","size":22,"edges":217,"triangles":1278,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":10},{"id":"GO:0051260","count":8},{"id":"GO:0071897","count":7},{"id":"GO:0061641","count":7},{"id":"GO:0006310","count":7}]},{"hash":"992187745203492554","title":"Diverse Metabolic Pathways","description":"The GO terms point to a broad mix of metabolic activities\u2014amino acid catabolism (leucine, valine, lysine), fatty acid oxidation, glycogen and cobalamin biosynthesis, prostaglandin and ascaroside biosynthesis, proteolysis, and even antibiotic response\u2014indicating no single cohesive pathway but rather a collection of varied metabolic processes. Confidence in this label is Medium.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0006552","count":3},{"id":"GO:0006574","count":3},{"id":"GO:1904070","count":3},{"id":"GO:0033540","count":3}]},{"hash":"2161878686820946233","title":"Nuclear mRNA Splicing and Processing","description":"These proteins cluster around nuclear mRNA maturation: spliceosome-mediated splicing (including alternative splicing), mRNA export, poly(A) tail regulation, and overall mRNA modification/stability, with additional ties to translation reinitiation. The dominant theme is splicing and processing of nascent transcripts rather than cytosolic translation, suggesting a spliceosome/mRNA maturation module.","confidence":"High","size":22,"edges":184,"triangles":894,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":10},{"id":"GO:0000380","count":9},{"id":"GO:0000381","count":9},{"id":"GO:0006378","count":9},{"id":"GO:0006406","count":8}]},{"hash":"1437972009601834616","title":"Detoxification and Aromatic Compound Catabolism","description":"This cluster shows strong signals for detoxification and breakdown of a broad set of organic compounds: cellular oxidant detoxification, beta-ketoadipate/aromatic compound catabolism, and various catabolic processes for plant- and microbe-derived compounds. The mix suggests metabolism and detoxification of diverse organic molecules rather than a single specific function.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0098869","count":11},{"id":"GO:0042952","count":10},{"id":"GO:0017000","count":10},{"id":"GO:0097755","count":10},{"id":"GO:0006212","count":10}]},{"hash":"197819326160461595","title":"cGMP/GPCR signaling in olfactory and immune pathways","description":"The cluster heavily features GO terms tied to cGMP signaling, including cellular response to cGMP and negative regulation of receptor guanylyl cyclase signaling, plus a strong signal for sensory perception of smell, which points to GPCR-mediated transduction in olfactory cells. At the same time, immune-related terms such as T cell receptor signaling, neutrophil chemotaxis, and IL-2 production suggest participation in immune cell signaling. The combination implies a core of GPCR/cGMP signaling with roles spanning sensory perception and immune responses. Some obsolete terms reflect historical annotations but do not alter the overall theme. ","confidence":"Medium","size":22,"edges":45,"triangles":20,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010754","count":12},{"id":"GO:0071321","count":12},{"id":"GO:0007608","count":12},{"id":"GO:0050852","count":11},{"id":"GO:0019933","count":11}]},{"hash":"1045211782103255103","title":"Nociception and Visual Temperature Response","description":"The cluster centers on sensory processing, with strong signals for pain perception, visual perception/learning, and temperature-related responses, plus neural signaling components (membrane potential regulation) and stimulus-driven behaviors (prostglandin signaling and drug-related responses). This suggests a coherent theme of neural sensory processing across nociceptive, visual, and temperature modalities.","confidence":"Medium","size":22,"edges":95,"triangles":137,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":22},{"id":"GO:0002024","count":21},{"id":"GO:0071502","count":21},{"id":"GO:0042391","count":21},{"id":"GO:0007601","count":21}]},{"hash":"1659888040312122476","title":"GPCR-driven cardiovascular and neurotransmitter signaling","description":"This cluster centers on GPCR signaling and its downstream effects, including positive regulation of GPCR pathways and related GTPase activity, as well as cardiovascular relevance via heart contraction regulation and vascular smooth muscle contraction, alongside neurotransmitter-related processes like dopamine and serotonin signaling. The convergence points to a module of GPCR-mediated control of heart/vessel function and neuromodulatory signaling.","confidence":"High","size":22,"edges":173,"triangles":711,"max_degree":21,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":22},{"id":"GO:0031649","count":22},{"id":"GO:2000420","count":22},{"id":"GO:0001997","count":22},{"id":"GO:0045745","count":22}]},{"hash":"502541329032482211","title":"Gene expression regulation and RNA processing","description":"The cluster includes terms tied to transcriptional control (negative regulation of RNA polymerase II, dosage compensation), RNA processing (mRNA splicing, rRNA maturation), and proteostasis (protein ubiquitination, proteolysis). The presence of Notch signaling and cell proliferation terms suggests broader roles in developmental regulation. Taken together, these proteins seem to function as regulators of gene expression and RNA metabolism, with supporting roles in signaling and protein turnover.","confidence":"Medium","size":22,"edges":37,"triangles":0,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0009048","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0042981","count":2}]},{"hash":"2116272206694219442","title":"Rho GTPase Signaling in Cardiovascular Development","description":"This cluster centers on small GTPase/Rho-mediated signaling (GO:0007264, GO:0035023, GO:0043547) with related cardiovascular themes such as heart development and vascular remodeling (GO:0007507, GO:0060313, GO:0030948). While some terms touch unrelated areas (sensory perception of sound), the dominant pattern points to Rho-regulated pathways governing cardiovascular development and vessel dynamics.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0045725","count":4},{"id":"GO:0007264","count":4},{"id":"GO:0002692","count":4},{"id":"GO:0007507","count":4}]},{"hash":"141324089977836372","title":"Neural actin dynamics and neurite outgrowth","description":"Based on the enrichment of actin cytoskeleton terms (actin crosslink formation, actin filament bundle assembly, barbed-end capping, Arp2/3-mediated nucleation) together with neural development terms (forebrain development, neuron projection development, Rac signaling, ruffle assembly), the cluster appears to group proteins involved in actin-driven neuronal morphogenesis and neurite extension. Metabolic signaling terms (insulin signaling, glycogen biosynthesis) are less central to this theme, likely secondary associations.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030900","count":3},{"id":"GO:0051764","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0016601","count":3},{"id":"GO:0051016","count":3}]},{"hash":"1713773968013081802","title":"Actin dynamics and signaling cluster","description":"Based on the top GO terms, these proteins are enriched for actin cytoskeleton regulation (barbed-end actin capping, cortical patch assembly) and signaling processes (GTPase activity regulation, tyrosine phosphorylation, TGF-beta response), with related stress responses (apoptosis, mitochondrial depolarization). The common theme is actin-driven remodeling tightly linked to signaling pathways, justifying this label.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043547","count":18},{"id":"GO:0051016","count":18},{"id":"GO:0000147","count":18},{"id":"GO:0071560","count":18},{"id":"GO:0050731","count":18}]},{"hash":"25316714338016595","title":"Immune and neural signaling regulators","description":"The top GO terms point to modulation of diverse signaling processes, including Rho and Ras pathways, IP3 biosynthesis, and NF-kappaB activity, along with implications in immune (B cell proliferation/differentiation) and neural (axonogenesis) contexts, as well as responses to mechanical stimuli. This suggests a set of proteins that broadly regulate signaling in immune and neural tissues rather than a single, narrow function. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016525","count":7},{"id":"GO:0035023","count":5},{"id":"GO:0007409","count":5},{"id":"GO:0051092","count":5},{"id":"GO:0071260","count":5}]},{"hash":"373825858446349104","title":"RNA processing and ribosome biogenesis","description":"The cluster's strongest GO terms are mRNA splicing via spliceosome and maturation of SSU-rRNA, pointing to RNA processing and ribosome assembly. Other terms suggest broader cellular logistics and nutrient signaling, but the RNA-centric terms dominate the functional theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000398","count":8},{"id":"GO:0006890","count":8},{"id":"GO:0038202","count":8},{"id":"GO:0010255","count":7},{"id":"GO:0006625","count":7}]},{"hash":"1755297349938135035","title":"GPCR-Mediated Vascular Tone Regulation","description":"This cluster is dominated by GO terms for GPCR signaling that activates adenylyl cyclase and PLC, Rho signaling, smooth muscle contraction regulation, and specifically positive regulation of blood pressure, pointing to proteins involved in vascular signaling and control of vascular tone.","confidence":"High","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":16},{"id":"GO:0022900","count":16},{"id":"GO:0010579","count":16},{"id":"GO:0035025","count":13},{"id":"GO:0007190","count":11}]},{"hash":"1636964168381970592","title":"Endocrine Regulation of Cardiovascular Function","description":"The terms indicate hormonal biosynthesis and signaling (e.g., aldosterone biosynthesis, receptor signaling) coupled with cardiovascular processes (vasoconstriction, SA node action potential regulation) and calcium transport, suggesting an endocrine control of heart/blood vessel function with calcium signaling. An ossification term appears as a potential outlier, but the core theme is endocrine-cardiovascular regulation with ion signaling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":22},{"id":"GO:0010754","count":21},{"id":"GO:2000340","count":21},{"id":"GO:0097050","count":21},{"id":"GO:0048016","count":21}]},{"hash":"120629107166427222","title":"GPCR Signaling and Cardiovascular-Immune Modulation","description":"The cluster\u2019s terms center on GPCR signaling and its regulation, along with cardiovascular effects such as heart contraction force and vascular smooth muscle contraction, plus immune-related processes like dendritic cell chemotaxis and eosinophil regulation. This suggests a cohesive theme of GPCR-mediated signaling coordinating cardiovascular function and immune cell trafficking.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":14},{"id":"GO:0031649","count":14},{"id":"GO:2000420","count":14},{"id":"GO:0001997","count":14},{"id":"GO:0045745","count":14}]},{"hash":"263872880868662200","title":"Inflammation, pain perception, and vascular response","description":"This cluster is dominated by GO terms related to inflammatory processes (inflammatory response, response to lipopolysaccharide), pain perception (sensory perception of pain), and vascular changes (vasoconstriction, blood coagulation). Additional terms for thermogenesis and heat generation may reflect metabolic shifts during inflammation or fever. Although there are no reported edges among proteins, the shared functional themes point to an inflammatory/pain-vascular functional module, justifying the proposed label.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":17},{"id":"GO:0045986","count":16},{"id":"GO:0032496","count":16},{"id":"GO:0006954","count":16},{"id":"GO:0045907","count":16}]},{"hash":"171143033089048971","title":"Autonomic GPCR signaling and cardiovascular regulation","description":"The top GO terms converge on GPCR signaling and downstream autonomic effects: regulation of heart contraction by adrenergic signaling, vascular smooth muscle contraction, insulin secretion regulation, and serotonin receptor signaling, all via GPCR pathways. Additional terms such as heat generation and fear response reflect sympathetic nervous system activation and CNS-linked processes, while the broad term on GPCR signaling supports a cohesive theme. Overall, the cluster appears to represent GPCR-mediated autonomic regulation of cardiovascular and metabolic functions.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008284","count":18},{"id":"GO:0050796","count":18},{"id":"GO:0001662","count":18},{"id":"GO:0033861","count":17},{"id":"GO:0031649","count":17}]},{"hash":"816432109587390275","title":"mRNA Splicing and Processing","description":"The cluster is enriched for spliceosome-mediated regulation of mRNA splicing, including alternative splicing, mRNA export, and polyadenylation/mRNA maturation, suggesting a cohesive role in splicing control and RNA processing.","confidence":"High","size":22,"edges":208,"triangles":1145,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":13},{"id":"GO:0048026","count":11},{"id":"GO:0006378","count":11},{"id":"GO:0031047","count":11},{"id":"GO:0000381","count":10}]},{"hash":"926677148867622519","title":"Cardiac and vascular GPCR signaling and contraction","description":"This cluster centers on GO terms related to GPCR signaling regulation, heart contraction influenced by adrenaline/norepinephrine, and vascular smooth muscle contraction, pointing to proteins involved in GPCR-mediated signaling that controls cardiac and vascular function. The mix of cardiovascular-specific terms with GPCR and signaling regulation supports a cohesive cardiac-vascular GPCR theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":22},{"id":"GO:0031649","count":22},{"id":"GO:2000420","count":22},{"id":"GO:0001997","count":22},{"id":"GO:0045745","count":22}]},{"hash":"1492054269643607784","title":"Cardiac signaling and conduction","description":"The top GO terms point to cardiac-specific processes: Notch signaling in heart field development, regulation of SA node pacemaker activity, and communication between SA node and atrial cardiac muscle cells, plus calcium ion import essential for contraction and broader signaling roles. While some terms (like thermoception or general multicellular processes) are less specific, the dominant theme across terms is cardiac signaling and electrical conduction.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":6},{"id":"GO:0044707","count":5},{"id":"GO:2000340","count":5},{"id":"GO:0003270","count":5},{"id":"GO:0098907","count":5}]},{"hash":"182844651441349124","title":"Specialized metabolite biosynthesis","description":"The GO terms point to multiple biosynthetic and related catabolic processes for diverse small molecules (retinoids, vitamins, antibiotics, alkaloids, mycolic acids), indicating a cluster of proteins involved in the production and turnover of specialized metabolites rather than a single pathway.","confidence":"High","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042572","count":4},{"id":"GO:0006729","count":3},{"id":"GO:0042376","count":3},{"id":"GO:0071768","count":3},{"id":"GO:0006710","count":3}]},{"hash":"1627191476853665","title":"GPCR Signaling Regulators","description":"The cluster shows strong enrichment for regulation of GPCR signaling (GO:0045745) and related pathways such as adrenergic control of heart contraction, serotonin receptor signaling, dopamine secretion, and immune cell chemotaxis, suggesting these proteins broadly modulate GPCR signaling across cardiovascular, neural, and immune contexts.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":22},{"id":"GO:0031649","count":22},{"id":"GO:2000420","count":22},{"id":"GO:0001997","count":22},{"id":"GO:0045745","count":22}]},{"hash":"1860437943743151748","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0030433","count":10},{"id":"GO:0051092","count":9},{"id":"GO:0043029","count":9},{"id":"GO:0070534","count":9}]},{"hash":"1420273393219426662","title":"Ubiquitin-Proteasome Regulation in Development","description":"The cluster shows strong enrichment of ubiquitin-dependent protein catabolism terms (including SCF-dependent proteasomal degradation), indicating core proteostasis activity. Additional signals point to circadian rhythm regulation and developmental processes such as neural tube closure and ventricle development, suggesting these proteins coordinate degradation with developmental timing and neuronal signaling. The mix of proteolysis and developmental terms supports a cohesive theme around ubiquitin\u2013proteasome\u2013driven regulation during development.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0042752","count":14},{"id":"GO:0021993","count":9},{"id":"GO:0031146","count":9},{"id":"GO:0051436","count":9}]},{"hash":"96699902368831772","title":"Auditory neuronal signaling and synaptic potentiation","description":"The terms point to neuronal signaling and synaptic function: ion channels mediating Na+/K+ transport, membrane depolarization, and excitatory postsynaptic potentials, plus paranodal junctions supporting fast nerve conduction and links to synaptic plasticity (LTP). A couple of outliers (virion attachment, zinc response) are less central but don't negate the central neuronal theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":6},{"id":"GO:0030913","count":6},{"id":"GO:0071805","count":5},{"id":"GO:0060079","count":5},{"id":"GO:0051899","count":5}]},{"hash":"1713416768458848007","title":"Unknown","description":"The terms point to brain development and neural structure (forebrain, neural tube, brain development) but also to immune response and general cellular processes (innate immunity, mRNA processing, DNA repair, dopamine response). With no clear, single unifying function and no edges linking proteins, there isn\u2019t a cohesive cluster theme to name reliably.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0030900","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0006397","count":3}]},{"hash":"1516843672499856872","title":"Sensory System Development and Neuronal Signaling","description":"Top GO terms point to sensory system development and function, including retinal rod cell development, photoreceptor organization, and sensory perception of sound, indicating a neural sensory theme. Additional terms on myelin assembly, Rho/Rap signaling, and intracellular transport fit neuronal signaling and trafficking, suggesting the cluster centers on sensory-neural development and signaling rather than a single pathway.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0032288","count":2},{"id":"GO:0032486","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0035845","count":2}]},{"hash":"2300622095703234484","title":"GPCR-Mediated Signaling Regulation","description":"The terms hub around GPCR signaling and its downstream effects: regulation of GPCR pathways, inhibition of adenylate cyclase via serotonin receptors, modulation of dopamine secretion, and GTPase activity. These connect to cardiovascular modulation (epinephrine/ norepinephrine\u2013driven heart contraction, vascular smooth muscle control) as well as immune and neural processes (dendritic cell chemotaxis, neurotransmitter signaling). This suggests a coherent theme of regulation of GPCR signaling across cardiovascular, neural, and immune contexts.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":22},{"id":"GO:0031649","count":22},{"id":"GO:2000420","count":22},{"id":"GO:0001997","count":22},{"id":"GO:0045745","count":22}]},{"hash":"1879380414845490976","title":"Neurovascular and sensory development","description":"The top GO terms cluster around developmental processes across neural (Schwann cell development, axonogenesis), vascular (angiogenesis, heart development) and sensory systems (visual perception). There are signaling-related terms as well, suggesting these proteins function in developmental signaling pathways that coordinate neural, vascular, and sensory organogenesis. While some terms are broad or species-specific (e.g., ABA signaling), the dominant theme is developmentally coordinated signaling across neurovascular and sensory contexts.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":6},{"id":"GO:0009738","count":5},{"id":"GO:0014044","count":5},{"id":"GO:0007409","count":5},{"id":"GO:0010800","count":5}]},{"hash":"820021549979848435","title":"Neural morphogenesis and cytoskeletal dynamics","description":"This cluster centers on actin-driven structures (lamellipodium/filopodium assembly), GTPase activation, and cell spreading, combined with neural development terms like midbrain morphogenesis and PNS myelination. Together these point to proteins that coordinate cytoskeletal remodeling and neurite outgrowth during neural morphogenesis, with some regulatory influence on cell migration and extracellular interactions. Confidence: Medium","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060313","count":6},{"id":"GO:0002692","count":5},{"id":"GO:0043314","count":5},{"id":"GO:1904693","count":4},{"id":"GO:0090630","count":4}]},{"hash":"1487407121721532762","title":"GPCR Signaling Across Heart, Vessels, and Immune Cells","description":"The top GO terms cluster around GPCR signaling and its downstream effects, including regulation of heart contraction by catecholamines, vascular smooth muscle contraction, and dopamine-related signaling, plus dendritic cell chemotaxis and immune cell trafficking. This suggests a common theme of GPCR-driven signaling coordinating cardiovascular function with neural/immune communication.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":21},{"id":"GO:0031649","count":21},{"id":"GO:2000420","count":21},{"id":"GO:0001997","count":21},{"id":"GO:0045745","count":21}]},{"hash":"384241405465923550","title":"B cell\u2013driven immunoglobulin production and cytokine signaling","description":"The terms point to B cell\u2013related processes (immunoglobulin production, B cell apoptotic process) and broad cytokine regulation (positive regulation of IL-5, IL-6, IL-13, IL-23), along with defense responses to pathogens and granulocyte chemotaxis. This suggests a theme of adaptive humoral immunity coupled with cytokine-mediated inflammatory signaling and recruitment.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048305","count":2},{"id":"GO:0001783","count":2},{"id":"GO:0050832","count":2},{"id":"GO:2000664","count":2},{"id":"GO:0032747","count":2}]},{"hash":"634272089565355891","title":"Muscle and fat differentiation with ubiquitination regulation","description":"Based on the top GO terms, the cluster centers on differentiation toward muscle and fat cells (fat cell differentiation; skeletal muscle fiber development), with additional signals related to muscle physiology (swimming) and cellular stress responses (heat, ubiquitination regulation). The presence of both positive/negative regulation of ubiquitination and K33-linked ubiquitination points to a theme of protein modification regulation affecting development and muscle-associated processes, suggesting a coherent role in tissue differentiation coupled with post-translational control.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":3},{"id":"GO:0048741","count":3},{"id":"GO:1900242","count":3},{"id":"GO:0036268","count":3},{"id":"GO:0051103","count":2}]},{"hash":"159066602000634341","title":"MAPK-linked stress signaling and development","description":"The cluster prominently features a MAPK-related term (cell integrity MAPK cascade) along with apoptotic and stress-response processes (response to toxic substance, apoptotic process). Several terms point to developmental and tissue-specific processes (Schwann cell development, tricuspid valve morphogenesis, lung-associated mesenchyme development), suggesting a broader theme of signaling pathways guiding development while responding to cellular stress. Although a plant hormone term (abscisic acid-activated signaling) and vitamin D3 metabolism appear, the common thread appears to be MAPK-associated signaling linked to stress responses and developmental processes.","confidence":"Medium","size":21,"edges":192,"triangles":1029,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070640","count":21},{"id":"GO:0072709","count":21},{"id":"GO:0000196","count":21},{"id":"GO:0060484","count":21},{"id":"GO:0006915","count":21}]},{"hash":"23105384102039690","title":"Vertebrate heart outflow tract and vascular development","description":"The top GO terms point to heart morphogenesis (outflow tract), vascular development (lung vasculature, wound healing), and broader developmental processes (somitogenesis, osteoblast differentiation). Transcription by RNA polymerase II and calcium signaling, along with immune signaling (interleukin-4 response), support coordinated gene regulation during embryogenesis. Together this suggests a cluster centered on vertebrate heart/vasculature organogenesis.","confidence":"High","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":18},{"id":"GO:0035470","count":12},{"id":"GO:0003151","count":12},{"id":"GO:0071353","count":9},{"id":"GO:0071277","count":9}]},{"hash":"1681495045911467387","title":"Ubiquitin-Proteasome and Autophagy in Development","description":"The top GO terms cluster around protein quality control and modification (ubiquitination, sumoylation, ERAD) and autophagy regulation, alongside developmental processes (gonad, lung, kidney development). This suggests a cohesive theme of proteostasis modulating development.","confidence":"Medium","size":21,"edges":7,"triangles":3,"max_degree":4,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0008584","count":7},{"id":"GO:0045648","count":6},{"id":"GO:1903265","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0016925","count":5}]},{"hash":"2008115716598586480","title":"Neuronal development and axon guidance","description":"The cluster shows strong representation of neuron development, axon guidance (including motor neuron and peripheral nervous system axonogenesis), dendritic spine morphogenesis, and synapse localization, with supporting terms in cell-matrix adhesion, receptor clustering, and Rho signaling that relate to cytoskeletal remodeling during neurite outgrowth and connectivity.","confidence":"High","size":21,"edges":17,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060396","count":10},{"id":"GO:0007160","count":10},{"id":"GO:0008045","count":10},{"id":"GO:0043113","count":6},{"id":"GO:0007266","count":6}]},{"hash":"368008263429807256","title":"Macrophage immune signaling and phagocytosis","description":"The top GO terms cluster around immune regulation (Notch signaling, NF-kappaB modulation, IL-2/IL-8 related regulation), phagocytosis, autophagy, and endocytic processes (including cholesterol-related receptor-mediated endocytosis), with some extracellular matrix involvement. This combination points to macrophage-like cells coordinating signaling with uptake and degradation pathways, rather than a single isolated pathway.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000483","count":3},{"id":"GO:0007219","count":3},{"id":"GO:0032088","count":3},{"id":"GO:0006909","count":3},{"id":"GO:0030199","count":3}]},{"hash":"899033091395711052","title":"Golgi-ER trafficking and mitotic chromatin assembly","description":"The cluster is driven by GO terms highlighting Golgi retention and ER-to-Golgi transport, plus microtubule severing and CENP-A\u2013containing chromatin assembly, which together point to intracellular transport processes coupled with chromosome organization during cell division. Some development or cytokine-response terms appear but the core signals center on Golgi/ER trafficking and mitotic chromatin machinery.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045053","count":5},{"id":"GO:0051260","count":5},{"id":"GO:0001824","count":4},{"id":"GO:0097011","count":4},{"id":"GO:0030433","count":4}]},{"hash":"291110406871364811","title":"Splicing Regulation and Translation Initiation","description":"The cluster is rich in GO terms for spliceosome-mediated and alternative mRNA splicing, mRNA export, and regulation of mRNA  processing (poly(A) tail shortening, mRNA modification), together with translation initiation factors (eIF4F complex assembly) and translation reinitiation, indicating a coherent group coordinating mRNA maturation and the start of translation.","confidence":"High","size":21,"edges":67,"triangles":134,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000380","count":8},{"id":"GO:0006406","count":7},{"id":"GO:0060211","count":7},{"id":"GO:0045292","count":7},{"id":"GO:0016556","count":7}]},{"hash":"1934643689312853327","title":"Mitochondrial metabolite transport and fission","description":"The cluster is dominated by GO terms for transporting metabolites and cofactors across the mitochondrial membrane (manganese ion, pyridoxal phosphate, citrate, ornithine, coenzyme A) and for mitochondrial membrane fission, pointing to proteins that mediate mitochondrial transport and mitochondrial dynamics; the insulin/glucose signaling terms likely reflect broader metabolic regulation linked to mitochondrial function.","confidence":"High","size":21,"edges":101,"triangles":197,"max_degree":17,"top_function":"protein folding","top_go_terms":[{"id":"GO:0006828","count":17},{"id":"GO:0031921","count":17},{"id":"GO:0006843","count":17},{"id":"GO:0090149","count":17},{"id":"GO:0000066","count":17}]},{"hash":"1864744229443408266","title":"Rho/Ras GTPase Signaling and Cell Migration","description":"The cluster centers on small GTPase\u2013mediated signaling with strong representation of Rho and Ras pathway regulators, including regulation of Rho signaling and negative regulation of Ras signaling, alongside processes like cell migration and lamellipodium assembly. This suggests a core theme of cytoskeletal remodeling and motility driven by GTPase signaling, with additional GO terms touching on broader developmental and signaling contexts (e.g., heart development, insulin signaling, IL-4 production, and B cell maturation) that reflect the multifunctionality of these pathways. Therefore, a concise label emphasizing Rho/Ras GTPase signaling coupled to cell migration best captures the shared function of the proteins in this cluster.","confidence":"Medium","size":21,"edges":29,"triangles":0,"max_degree":17,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":19},{"id":"GO:0035023","count":19},{"id":"GO:0016477","count":18},{"id":"GO:0007264","count":18},{"id":"GO:0046580","count":18}]},{"hash":"1302140206127797893","title":"Developmental signaling and apoptosis","description":"This cluster is enriched for apoptosis-related terms and developmental signals, including positive regulation of GTPase activity and canonical Wnt signaling, plus brain and heart development and synaptic plasticity. The convergence on signaling controlling cell fate, growth, and cytoskeletal remodeling suggests a group of proteins involved in development and apoptosis, particularly in neural and cardiac contexts. Therefore the label Developmental signaling and apoptosis is appropriate.","confidence":"Medium","size":21,"edges":5,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006915","count":8},{"id":"GO:0043547","count":6},{"id":"GO:0090263","count":6},{"id":"GO:0006919","count":5},{"id":"GO:0043065","count":5}]},{"hash":"1787435859647872668","title":"UV-induced DNA repair and damage response","description":"The top GO terms cluster around UV exposure (response to UV-B/UV-C) and pyrimidine dimer repair by nucleotide-excision repair, pointing to a DNA damage response role. Additional terms on regulation of the cell cycle and transcription by RNA polymerase II fit DDR signaling that coordinates repair with transcription and cell-cycle control. Some terms are obsolete or peripheral, but the dominant theme is UV-induced DNA damage response and repair.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071157","count":3},{"id":"GO:0006407","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0061178","count":2}]},{"hash":"1275761594376445618","title":"Cardiac conduction and immune regulation","description":"The cluster includes GO terms tied to cardiac electrical activity (SA node action potential, heart rate regulation, ventricular repolarization, atrial depolarization) and immune processes (NK and T cell regulation, complement activation, phagocytosis recognition), plus actin cytoskeleton regulation via cell\u2013cell adhesion. This points to proteins with roles in both cardiac function and immune signaling or interfaces between these systems. Confidence: Medium","confidence":"","size":21,"edges":82,"triangles":81,"max_degree":13,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002859","count":8},{"id":"GO:0006958","count":8},{"id":"GO:0086015","count":8},{"id":"GO:0086091","count":8},{"id":"GO:0006910","count":8}]},{"hash":"1613318482594053086","title":"Neural Development and Synapse Assembly","description":"This cluster centers on nervous system development, brain development, and synapse assembly, with multiple terms for cell adhesion and corticospinal tract morphogenesis, indicating a cohesive theme of neural development and synapse formation.","confidence":"High","size":21,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":21},{"id":"GO:0051965","count":21},{"id":"GO:0007156","count":21},{"id":"GO:0021957","count":21},{"id":"GO:0007157","count":21}]},{"hash":"662811826988451210","title":"Neuronal development and vesicle trafficking","description":"The frequent terms point to nervous system development and axon guidance, combined with membrane trafficking processes (ER-to-Golgi transport, endocytosis) and cell polarity. This suggests a cluster of proteins coordinating neuronal morphogenesis, signaling, and membrane dynamics.","confidence":"High","size":21,"edges":103,"triangles":190,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010628","count":10},{"id":"GO:0055091","count":10},{"id":"GO:0006888","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0007411","count":7}]},{"hash":"334722986012065326","title":"RNA processing and translation initiation","description":"Top GO terms indicate a cluster centered on RNA processing, including splicing via spliceosome and regulatory ncRNA-mediated gene silencing, alongside translation initiation steps and rRNA maturation. This suggests proteins that participate in RNA maturation and the assembly of translation machinery, with embryonic development as a broader related process. Confidence reflects strong alignment of multiple terms to RNA processing and early translation components.","confidence":"High","size":21,"edges":8,"triangles":0,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":9},{"id":"GO:0048026","count":9},{"id":"GO:0000398","count":8},{"id":"GO:0045292","count":7},{"id":"GO:0002188","count":7}]},{"hash":"1122925257571051494","title":"Cell division and intracellular transport proteins","description":"Top GO terms highlight cell cycle and cytoskeletal/trafficking functions (cell division; CENP-A chromatin assembly; microtubule severing; ER-to-Golgi transport) and protein complex formation (protein homooligomerization), suggesting a cluster of proteins coordinating mitosis with intracellular transport and chromatin organization. Brain development and metabolic signaling terms appear less central, possibly reflecting broader roles or expression patterns rather than the core function of the cluster.","confidence":"Medium","size":21,"edges":94,"triangles":165,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0051013","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0051260","count":4}]},{"hash":"315395293383998429","title":"Embryonic tissue morphogenesis and immune signaling","description":"This cluster prominently features developmental processes (cartilage condensation, mesonephric duct development, metanephric tubule morphogenesis) and cell-matrix adhesion, indicating roles in tissue morphogenesis and ECM interactions. The co-occurrence of immune-related GO terms (type I interferon signaling, phagocytosis recognition, NK cell chemotaxis regulation) suggests a subset of proteins also participate in immune modulation during development, justifying a combined theme.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071226","count":12},{"id":"GO:0001502","count":11},{"id":"GO:0010572","count":9},{"id":"GO:0006910","count":9},{"id":"GO:0060337","count":9}]},{"hash":"1744453835589399370","title":"Immune signaling and hematopoietic development","description":"These proteins cluster around both innate/adaptive immune signaling (neutrophil chemotaxis, type I interferon pathway, B and T cell receptor signaling, KIT pathway) and hematopoietic processes (megakaryocyte development, Rho signaling, IP3 biosynthesis). The shared themes point to a group involved in coordinating immune responses with hematopoietic lineage development rather than a single, narrow function.","confidence":"Medium","size":21,"edges":19,"triangles":4,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071226","count":11},{"id":"GO:0030593","count":11},{"id":"GO:0060337","count":10},{"id":"GO:0050853","count":9},{"id":"GO:0001525","count":9}]},{"hash":"1789575948301641090","title":"Ribosome biogenesis and translation","description":"The cluster is strongly enriched for translation-related terms, including cytoplasmic and mitochondrial translation, ribosome assembly/biogenesis, and translational termination/fidelity, indicating a cohesive group centered on protein synthesis machinery. Minor outliers (response to antibiotic, nerve growth factor stimulus) do not define the cluster.","confidence":"High","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":16},{"id":"GO:0032543","count":3},{"id":"GO:0046677","count":2},{"id":"GO:0006450","count":2},{"id":"GO:0006415","count":2}]},{"hash":"1209632657394084037","title":"Eye and brain development","description":"The top GO terms show strong enrichment for eye-related processes (camera-type eye development, visual perception, embryonic eye morphogenesis) and broader brain development (midbrain/forebrain development, brain development), plus multicellular organism development. This suggests a cohesive cluster of proteins involved in ocular and neural morphogenesis and function.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043010","count":8},{"id":"GO:0007601","count":8},{"id":"GO:0000122","count":7},{"id":"GO:0008584","count":6},{"id":"GO:0007275","count":6}]},{"hash":"2224484120889295104","title":"Developmental signaling and morphogenesis","description":"The top GO terms are dominated by developmental and morphogenic processes (Wnt signaling, eye morphogenesis, cloacal septation, neuronal differentiation, and synapse assembly). Although some terms relate to transcriptional regulation and immune pathways, the overall pattern points to broadly developmental signaling and morphogenesis across tissues, making this a concise, representative label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":6},{"id":"GO:0048593","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0006958","count":5},{"id":"GO:0071372","count":4}]},{"hash":"522194622242577839","title":"Metabolic Biosynthesis and Transcription Regulation","description":"The cluster is enriched for diverse biosynthetic and metabolic processes (fatty acid, carbohydrate, gluconeogenesis, nucleotide synthesis) along with regulatory functions (activation of protein kinase activity, RNA Pol II\u2013mediated transcription) and cell cycle involvement. This suggests a set of proteins coordinating metabolism with growth and transcriptional control rather than a single linear pathway.","confidence":"Medium","size":21,"edges":34,"triangles":28,"max_degree":13,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0045944","count":7},{"id":"GO:0006633","count":6},{"id":"GO:0007049","count":6},{"id":"GO:0005975","count":5},{"id":"GO:0070814","count":5}]},{"hash":"1815385258604477328","title":"RNA Processing and Antiviral Innate Immunity","description":"This cluster is dominated by GO terms for RNA metabolism and immune defense: miRNA processing, siRNA processing, mRNA processing, and rRNA catabolic process, plus innate immune response and negative regulation of viral genome replication. A couple of neural development terms appear but are less central; the core theme appears to be RNA processing coupled with antiviral innate immunity.","confidence":"High","size":21,"edges":209,"triangles":1311,"max_degree":20,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0035196","count":11},{"id":"GO:0045071","count":11},{"id":"GO:0016075","count":11},{"id":"GO:0021610","count":11},{"id":"GO:0061744","count":11}]},{"hash":"2157348854259007451","title":"Membrane signaling and vesicle exocytosis","description":"The top GO terms point to membrane-related signaling and vesicle trafficking/exocytosis processes: regulation of synaptic vesicle exocytosis, acrosome reaction, and plasma membrane repair, along with VEGF receptor signaling and Ras pathway modulation. Even though some terms (e.g., abscisic acid signaling) are less directly connected, the prevailing theme is membrane-associated signaling and vesicle dynamics, suggesting these proteins cluster around membrane trafficking and exocytic regulation. Confidence: Medium.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035690","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0036324","count":3},{"id":"GO:0009738","count":3},{"id":"GO:0007340","count":3}]},{"hash":"1613685959999560260","title":"Developmental Signaling and Cytoskeletal Dynamics","description":"The terms point to roles in developmental processes (hair follicle morphogenesis, nervous system development, canonical Wnt signaling) combined with cytoskeletal regulation and membrane trafficking (GTPase activity, endocytosis, filopodium regulation, tight junction assembly). This suggests a cluster of proteins coordinating signaling with cytoskeletal remodeling and cell\u2011cell adhesion during development and tissue morphogenesis. Some GO terms are obsolete, but the cohesive theme remains developmentally oriented and cytoskeleton-associated.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0070830","count":4},{"id":"GO:0006897","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0051489","count":4}]},{"hash":"1807318471605096080","title":"Rho-driven actin remodeling and GPCR endocytosis","description":"This cluster reflects actin cytoskeleton remodeling governed by Rho GTPases, with processes like microspike assembly, actin organization, GPCR internalization, and clathrin-mediated endocytosis.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030035","count":5},{"id":"GO:0007205","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0032956","count":3},{"id":"GO:0043547","count":3}]},{"hash":"60531583744556329","title":"T and B cell activation signaling","description":"The cluster is enriched for adaptive immune terms centered on T and B cell activation, including T cell costimulation, positive regulation of T and B cell proliferation, B cell receptor signaling, and complement activation. The presence of innate immune response and cell\u2013cell adhesion terms supports roles in immune cell interactions and immune synapse formation.","confidence":"High","size":21,"edges":11,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0031295","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0007157","count":5},{"id":"GO:0007156","count":5},{"id":"GO:0002250","count":5}]},{"hash":"1555487616507523690","title":"Vitamin, lipid, and secondary metabolite biosynthesis","description":"The top GO terms indicate a broad set of biosynthetic and lipid-related metabolic processes, including vitamin/cofactor biosynthesis (tetrahydrobiopterin, phylloquinone, retinoic acid/retinal), lipid pathways (mycolic acid, fatty acid elongation, sphinganine), and secondary metabolite production (antibiotics, tropane alkaloids). This suggests a cluster enriched for diverse biosynthetic/metabolic capabilities rather than a single specific function.","confidence":"High","size":21,"edges":116,"triangles":296,"max_degree":18,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006729","count":15},{"id":"GO:0042376","count":15},{"id":"GO:0071768","count":15},{"id":"GO:0006710","count":15},{"id":"GO:0002138","count":15}]},{"hash":"412491941440346262","title":"GPCR-activated cAMP signaling network","description":"The top GO terms show strong enrichment for GPCR signaling and adenylate cyclase activation (GO:0010579, GO:0072224, GO:0007190), suggesting a core theme around GPCR-coupled cAMP signaling. Additional terms span vascular regulation, inflammatory/defense responses, and development, implying broader regulatory roles for these proteins beyond a single pathway. The electron transport chain term may reflect metabolic facets or annotation overlap but does not outweigh the GPCR-cAMP theme. Overall, GPCR-mediated signaling is the most coherent thread linking these terms.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":17},{"id":"GO:0022900","count":17},{"id":"GO:0010579","count":17},{"id":"GO:0035025","count":17},{"id":"GO:0042742","count":16}]},{"hash":"2160831586128051197","title":"Diet-induced thermogenesis and GPCR-cAMP signaling","description":"This cluster is driven by terms centered on thermogenesis and temperature response (diet-induced thermogenesis, cellular response to temperature stimulus), coupled with GPCR-initiated cAMP signaling (adenylate cyclase activation) and links to energy metabolism (electron transport chain, membrane potential) and cardiovascular regulation (blood pressure). The convergence on temperature-driven metabolic signaling plus GPCR-cAMP pathways suggests a cohesive thermogenic/metabolic signaling module, with some peripheral annotation to sensory temperature/pain pathways. ","confidence":"High","size":21,"edges":4,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":14},{"id":"GO:0019233","count":14},{"id":"GO:0071502","count":14},{"id":"GO:0008284","count":12},{"id":"GO:0007190","count":12}]},{"hash":"717084304055738605","title":"Adrenergic GPCR-cAMP Cardiovascular Signaling","description":"The GO terms cluster around activation of adenylate cyclase, GPCR signaling, and regulation of heart contraction and vascular smooth muscle contraction, all classic outputs of adrenergic signaling (epinephrine/norepinephrine) affecting blood pressure and cardiac output. While metabolism-related terms like electron transport and heat generation appear, they likely reflect energetic support in cardiovascular tissues rather than a separate pathway. Thus, the dominant theme is adrenergic GPCR-cAMP signaling governing cardiovascular function.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":18},{"id":"GO:0045777","count":18},{"id":"GO:0022900","count":18},{"id":"GO:0010579","count":18},{"id":"GO:0033861","count":17}]},{"hash":"1409721325801554323","title":"Cardiovascular and Neuroimmune GPCR Signaling","description":"This cluster is best described as Cardiovascular and Neuroimmune GPCR Signaling. The top GO terms cluster around GPCR signaling and its regulation, including positive regulation of GPCR signaling, serotonin receptor signaling, and dopamine secretion, as well as heart contraction and vascular smooth muscle contraction. Immune cell trafficking terms like dendritic cell chemotaxis and regulation of eosinophil extravasation suggest GPCR-mediated control of immune responses, tying together cardiovascular, neuromodulatory, and immune signaling. The common thread is GPCR-driven signaling impacting heart/vascular function and neuroimmune processes.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":21},{"id":"GO:0031649","count":21},{"id":"GO:2000420","count":21},{"id":"GO:0001997","count":21},{"id":"GO:0045745","count":21}]},{"hash":"700025318890868666","title":"Developmental signaling and sensory response","description":"The terms emphasize organismal development (retina and skin development, multicellular development) and signaling processes (GTPase regulation, dopamine receptor signaling, adenylate cyclase activation), with additional environmental-responsive terms (temperature stimulus, diet-induced thermogenesis, pain perception). This points to a cluster of proteins involved in developmental signaling pathways coupled with sensory/temperature-responsive functions, rather than a single focused pathway.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008283","count":9},{"id":"GO:0043547","count":9},{"id":"GO:0002024","count":9},{"id":"GO:0019233","count":9},{"id":"GO:0071502","count":9}]},{"hash":"741506535696963227","title":"Cardiovascular Neurotransmitter GPCR Signaling","description":"This cluster centers on GPCR-mediated signaling affecting heart contraction, vascular smooth muscle, and dopamine/serotonin pathways, with downstream GTPase and adenylate cyclase regulation. While there are some immune-related terms, the dominant pattern points to neurochemical regulation of cardiovascular function via GPCR pathways.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":20},{"id":"GO:0031649","count":20},{"id":"GO:2000420","count":20},{"id":"GO:0001997","count":20},{"id":"GO:0045745","count":20}]},{"hash":"2048014519356083664","title":"GPCR Signaling in Cardiovascular and Immune Responses","description":"The top GO terms point to GPCR signaling and its regulation (positive regulation of GPCR signaling, GPCR pathway signaling, EGFR transactivation via GPCRs), along with downstream effectors like GTPase activity. There is a consistent emphasis on cardiovascular processes (heart contraction regulation, vascular smooth muscle contraction) and immune/immune cell movement (dendritic cell chemotaxis). Some terms are flagged as obsolete, but the cohesive theme remains GPCR-driven signaling influencing heart, vessels, and immune cell behavior.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035625","count":21},{"id":"GO:0033861","count":20},{"id":"GO:0031649","count":20},{"id":"GO:2000420","count":20},{"id":"GO:0001997","count":20}]},{"hash":"1985369784768149076","title":"Immune Activation and Cytokine Signaling","description":"The top GO terms are dominated by immune-related processes, including positive regulation of B cell activation, IL-4 production, cytokine production in immune response, and defense against bacteria, as well as regulation of NK cell activity. Although some terms touch on cardiac or junctional functions, the strongest signal reflects immune system activation and cytokine signaling, suggesting these proteins cluster around immune modulation rather than a single non-immune pathway.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086091","count":9},{"id":"GO:0086014","count":9},{"id":"GO:0030913","count":9},{"id":"GO:2000649","count":9},{"id":"GO:0030277","count":8}]},{"hash":"1458769442509523843","title":"Ubiquitin-Mediated Protein Degradation and TNF Signaling","description":"The cluster is dominated by ubiquitin-dependent protein catabolic processes and regulators of inflammatory/stress signaling (JNK cascade, I-kappaB phosphorylation, TNF signaling), with additional notes on histone ubiquitination and apoptotic regulation, suggesting a cohesive theme around ubiquitin-driven turnover and signaling control.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:0046328","count":12},{"id":"GO:1903721","count":11},{"id":"GO:0070535","count":11},{"id":"GO:0033209","count":11}]},{"hash":"1180593951977983562","title":"Immune signaling and cytoskeletal remodeling","description":"This cluster combines small GTPase and Rho/Ras-regulated signaling with lamellipodium assembly and several immune-related processes (B cell affinity maturation, IL-4 production, NK T cell differentiation, hemopoiesis), suggesting proteins that drive immune signal transduction alongside actin-driven cytoskeletal dynamics essential for immune cell activation and migration.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":14},{"id":"GO:0007264","count":13},{"id":"GO:0046580","count":13},{"id":"GO:0002344","count":13},{"id":"GO:0030032","count":13}]},{"hash":"157292177646255490","title":"Nervous system development and synapse assembly","description":"The top GO terms are dominated by neural-related processes: nervous system development, synapse assembly, axonal fasciculation, nerve impulse transmission, and cell adhesion, indicating proteins involved in neural development and synaptic connectivity. A couple of terms are unrelated or obsolete (bone ossification, defense response, obsolete MAPK/PI3K terms) and do not redefine the main theme. Overall, the cluster centers on neural development and synaptic organization.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":12},{"id":"GO:0000187","count":11},{"id":"GO:0042742","count":11},{"id":"GO:0007413","count":11},{"id":"GO:0043931","count":11}]},{"hash":"2191463081264574189","title":"GPCR Signaling Regulation and Immune Chemotaxis","description":"The cluster\u2019s top GO terms center on regulation of signaling, especially GPCR signaling (GO:0045745), along with regulation of dopamine secretion and GTPase activity, plus immune cell movement terms like dendritic cell chemotaxis and eosinophil extravasation. Some cardiovascular terms imply downstream effects of GPCR pathways, but the shared theme appears to be modulation of signaling with immune cell trafficking. Confidence: Medium","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":18},{"id":"GO:0031649","count":18},{"id":"GO:2000420","count":18},{"id":"GO:0001997","count":18},{"id":"GO:0045745","count":18}]},{"hash":"82675832552926288","title":"Actin Cytoskeleton Remodeling","description":"The cluster is dominated by GO terms related to actin filament dynamics (polymerization, capping, bundle assembly) and the assembly of actin-driven structures like lamellipodia and filopodia, indicating a shared function in actin remodeling and cell motility. Insulin receptor signaling terms are present but likely reflect a regulatory link to actin dynamics rather than a separate core theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051016","count":4},{"id":"GO:0030838","count":4},{"id":"GO:0046626","count":4},{"id":"GO:0030041","count":4},{"id":"GO:0030032","count":4}]},{"hash":"450240135122199648","title":"Ubiquitin-Mediated Proteostasis and Autophagy Regulation","description":"The cluster is dominated by terms tied to ubiquitin-dependent pathways (ERAD, deubiquitination, deglycosylation) and regulation of autophagy, pointing to a proteostasis module managing protein quality control through ubiquitin tagging and autophagic processes. While a few terms touch on other cellular processes (DNA repair, signaling, cell cycle), the strongest common theme is protein degradation and turnover via ubiquitin and autophagy pathways.","confidence":"Medium","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":10},{"id":"GO:0034140","count":7},{"id":"GO:1901340","count":6},{"id":"GO:1904378","count":6},{"id":"GO:0033132","count":6}]},{"hash":"35301461203678862","title":"Spinal cord patterning and interneuron differentiation","description":"The top GO terms cluster around neural development in the spinal cord, including motor neuron and oligodendrocyte fate specification, floor plate development, and interneuron differentiation (subpallium, GABAergic cortical interneurons). This suggests the proteins co-cluster as a group involved in spinal cord patterning and neuronal fate specification, with transcription by RNA polymerase II as a general background. ","confidence":"High","size":20,"edges":189,"triangles":1122,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":16},{"id":"GO:0001756","count":12},{"id":"GO:0021520","count":12},{"id":"GO:2001016","count":12},{"id":"GO:0060426","count":12}]},{"hash":"1802520490293876923","title":"Neural signaling and synaptic components","description":"This cluster is enriched for terms tied to neural communication: localization of proteins to synapses, glutamate secretion, and sensory perception of light, along with behavioral and morphine-related responses. It also includes terms related to neuronal cell junctions and myelin-adjacent regions, and a general signaling regulator (JNK cascade), suggesting a coherent theme of synaptic signaling and neuronal junction organization.","confidence":"Medium","size":20,"edges":101,"triangles":224,"max_degree":18,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0090557","count":12},{"id":"GO:2000821","count":11},{"id":"GO:0035418","count":11},{"id":"GO:0019933","count":11},{"id":"GO:0045186","count":11}]},{"hash":"2039267513167009648","title":"Proteostasis and Degradation Pathways","description":"This cluster centers on protein quality control, including ubiquitin-dependent ERAD, protein sumoylation, and regulation of ERAD, with accompanying autophagy-related processes (nuclear piecemeal autophagy) and apoptosis execution, plus lipid droplet organization, suggesting a cohesive theme of proteostasis and subcellular turnover under stress.","confidence":"High","size":20,"edges":162,"triangles":714,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":6},{"id":"GO:0007205","count":4},{"id":"GO:0097194","count":4},{"id":"GO:0016925","count":4},{"id":"GO:0034389","count":3}]},{"hash":"1696256780069263843","title":"Negative regulation of signaling pathways and neural development","description":"The top GO terms cluster around negative regulation of signaling and dephosphorylation (peptidyl-tyrosine dephosphorylation, ERK/MAPK regulation, T cell receptor signaling, insulin signaling), with additional notes on neuron development and cell cycle-related processes (kinetochore localization). This points to a theme of inhibitory control over multiple signaling networks, including neural and immune contexts, rather than a single specific pathway.","confidence":"Medium","size":20,"edges":154,"triangles":641,"max_degree":18,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035335","count":12},{"id":"GO:0032435","count":9},{"id":"GO:0048666","count":9},{"id":"GO:0070373","count":8},{"id":"GO:0045736","count":7}]},{"hash":"2151101434921374250","title":"Neural development and interneuron differentiation","description":"This cluster is enriched for GO terms tied to neural development and neuron subtype specification, including spinal cord motor neuron cell fate, spinal cord oligodendrocyte fate, subpallium neuron fate commitment, and cerebral cortex GABAergic interneuron differentiation. It also shows strong transcriptional regulation signals (DNA-templated transcription, RNA polymerase II transcription) and histone deacetylation, suggesting epigenetic control of neural differentiation. A few terms (endocrine pancreas development and osteoblast differentiation) are less clearly connected to neural programs, but the dominant theme is transcriptional control guiding neural development.","confidence":"Medium","size":20,"edges":182,"triangles":1004,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":11},{"id":"GO:0045668","count":11},{"id":"GO:0060766","count":11},{"id":"GO:0070932","count":11},{"id":"GO:0006366","count":10}]},{"hash":"436097506549053821","title":"Osteo-vascular development and ER stress signaling","description":"Top terms emphasize transcriptional regulation by RNA polymerase II and involvement in bone (osteoblast differentiation) and vascular development (vascular wound healing, outflow tract morphogenesis), with ER stress/unfolded protein response terms also present. This suggests a cluster coordinating transcriptional programs for bone and vascular development alongside cellular stress signaling. Medium","confidence":"","size":20,"edges":188,"triangles":1105,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0045669","count":10},{"id":"GO:0035470","count":10},{"id":"GO:0071277","count":9},{"id":"GO:0003151","count":9}]},{"hash":"97720831986592372","title":"Embryonic organogenesis and eye development","description":"These GO terms cluster around embryonic development and morphogenesis across multiple tissues, especially eye morphogenesis (camera-type eye development, embryonic eye morphogenesis), nervous system development (peripheral nervous system neuron development, midbrain development), inner ear development, hindlimb morphogenesis, and primitive streak formation. The transcription-related terms suggest regulation of gene expression during development, reinforcing a cohesive theme of embryonic organogenesis and morphogenesis.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0090009","count":9},{"id":"GO:0043010","count":8},{"id":"GO:0060441","count":8},{"id":"GO:0006366","count":8}]},{"hash":"1284260284938587344","title":"RNA Pol II Transcription Initiation and Regulation","description":"Most top GO terms point to RNA polymerase II\u2013mediated transcription, including DNA-templated transcription initiation and RNA Pol II preinitiation complex assembly, with negative regulation of transcription by RNA Pol II as a strong signal. A few additional terms (DNA repair and stress responses) are present but less central. Overall, the cluster aligns with transcription initiation/regulation functions.","confidence":"High","size":20,"edges":22,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0006352","count":3},{"id":"GO:0051123","count":3},{"id":"GO:0006281","count":2},{"id":"GO:0060548","count":2}]},{"hash":"1145944481559201940","title":"Epithelial Actin Cytoskeleton and Microvilli","description":"This cluster centers on actin cytoskeleton regulation and epithelial surface organization: Rho signaling, actin filament dynamics, focal adhesion assembly, and structures like microvilli and the terminal web, suggesting a cohesive role in epithelial cell cortex organization and surface absorption. Developmental patterning terms appear less central but fit with epithelial polarity and stalk formation contexts, reinforcing a theme of cytoskeletal control of epithelial structure and function.","confidence":"High","size":20,"edges":19,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0030713","count":4},{"id":"GO:0070493","count":3},{"id":"GO:0048041","count":3},{"id":"GO:0032532","count":3}]},{"hash":"2062462421395948214","title":"Endosome trafficking in neural development","description":"The cluster\u2019s GO terms cluster around endosomal transport (endosome to lysosome, early to late endosome) and regulation of GTPase activity, a core vesicle trafficking pathway. Coupled with Schwann cell development and cell morphogenesis terms, this suggests a role in neural development through endocytic processes. Additional neural-related signals (response to cocaine, nitric oxide) and transcription/mRNA processing terms support a broader neural regulatory context, but the dominant theme is endosomal trafficking linked to neural development.","confidence":"Medium","size":20,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000902","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0008333","count":3},{"id":"GO:0045022","count":3},{"id":"GO:0014044","count":2}]},{"hash":"2076758701129560017","title":"Calcium-Dependent Neuronal Signaling and Memory","description":"The proteins are enriched for neuronal signaling and memory-related GO terms, including visual perception, neurotransmitter secretion, calcium release, and calcium-modulated pathways (Wnt/calmodulin\u2013NFAT signaling). Together these suggest calcium-driven synaptic activity and memory-associated processes, with a few less directly related terms present. This combination supports the label as a concise theme, though not perfectly cohesive across all terms.","confidence":"Medium","size":20,"edges":17,"triangles":2,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":5},{"id":"GO:0051281","count":5},{"id":"GO:0007223","count":5},{"id":"GO:0007269","count":5},{"id":"GO:0000278","count":5}]},{"hash":"1160052480667430391","title":"Neural Development and Signaling","description":"These proteins are strongly annotated with nervous system development, synapse assembly, and myelination, suggesting a core role in neural maturation and connectivity. They also align with multiple signaling pathways (ROBO, Hedgehog/SMO, RTK signaling) and tissue development terms (heart, kidney), indicating involvement in broad developmental signaling networks beyond just neural contexts. Overall, the dominant theme is neural development and associated signaling processes.","confidence":"Medium","size":20,"edges":14,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007399","count":13},{"id":"GO:0050852","count":12},{"id":"GO:0035385","count":12},{"id":"GO:0051965","count":12},{"id":"GO:0042552","count":12}]},{"hash":"1943417295258104032","title":"Neural development and cadherin-mediated synapse formation","description":"The top GO terms coalesce around nervous system development, synapse assembly, and cadherin-based cell adhesion, including both heterophilic/homophilic adhesion and cadherin-mediated adhesion, as well as auditory system development and sensory perception of sound. These together point to a coherent theme of neural development with a focus on synapse formation and tissue organization mediated by cadherins, with ossification reflecting broad developmental context.","confidence":"High","size":20,"edges":37,"triangles":13,"max_degree":10,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0007157","count":14},{"id":"GO:0007156","count":14},{"id":"GO:0051965","count":13},{"id":"GO:0043931","count":13},{"id":"GO:0007399","count":13}]},{"hash":"419143439947416922","title":"Mitosis Regulation and Kinetochore Localization","description":"This cluster features strong signals for mitotic control and kinetochore-related processes (DNA-templated transcription, protein localization to kinetochore, and regulation of sister chromatid biorientation), complemented by regulators of signaling pathways (ERK/JNK) and transcription. The repeated emphasis on positive/negative regulation of mitosis and kinetochore functions, with broader transcriptional regulatory cues, points to a nuclear regulatory module coordinating cell division and signaling.","confidence":"Medium","size":20,"edges":22,"triangles":0,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0045736","count":4},{"id":"GO:0034501","count":4},{"id":"GO:0070373","count":3},{"id":"GO:0098783","count":3}]},{"hash":"311932855777207353","title":"mRNA Splicing and Processing","description":"Based on the top GO terms, this cluster is dominated by mRNA maturation activities\u2014cis-splicing by the spliceosome, alternative splicing via spliceosome, splice-site recognition, and regulation of splicing\u2014along with related processes such as mRNA polyadenylation, poly(A) tail regulation, mRNA export, and general mRNA modification. This pattern points to a cohort of proteins involved in RNA processing in the nucleus, particularly splicing machinery and associated maturation steps.","confidence":"High","size":20,"edges":50,"triangles":13,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":14},{"id":"GO:0006378","count":14},{"id":"GO:0006406","count":11},{"id":"GO:0000380","count":11},{"id":"GO:0060211","count":11}]},{"hash":"442141257836529644","title":"Mitochondrial Translation and Respiratory Chain Assembly in Development","description":"The cluster is dominated by mitochondrial-specific terms: mitochondrial translation, mitochondrial electron transport, and respiratory chain complex I assembly, indicating a core theme of mitochondrial protein synthesis and respiration. Additional embryonic/brain development terms suggest a developmental context where mitochondrial function is crucial.","confidence":"High","size":20,"edges":189,"triangles":1122,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0001701","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0032543","count":2},{"id":"GO:0006123","count":2}]},{"hash":"2165699906480284337","title":"Unknown","description":"The top GO terms cover a wide array of metabolic activities rather than a single coherent function, spanning multiple biosynthetic pathways (phylloquinone, tetrahydrobiopterin, retinoid, mycolic acid, antibiotic, tropane alkaloid, retinal metabolism) plus androgen catabolic processes and a general redox-related term. The diversity suggests no unifying function for the cluster. Additionally, the connectivity is very weak (one edge, zero triangles), which further indicates the proteins do not form a focused functional module. Therefore, a precise, specific label cannot be inferred.","confidence":"","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0050821","count":2},{"id":"GO:0006729","count":2},{"id":"GO:0042376","count":2},{"id":"GO:0071768","count":2}]},{"hash":"1862316917999332024","title":"Immune Activation and Cell-Cell Signaling","description":"The cluster is enriched for complement activation, phagocytosis, B and T cell signaling/activation, and cell adhesion, indicating coordinated innate and adaptive immune responses and intercellular communication. This supports a label focused on immune signaling and effector engagement.","confidence":"High","size":20,"edges":137,"triangles":449,"max_degree":17,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":12},{"id":"GO:0007157","count":12},{"id":"GO:0006911","count":11},{"id":"GO:0050853","count":11},{"id":"GO:0006910","count":11}]},{"hash":"1507777694083762121","title":"TNF-NF-\u03baB Immune Signaling with Autophagy","description":"GO terms emphasize TNF-mediated signaling, adaptive immune responses (including T cell proliferation), NF-\u03baB regulation via I\u03baB phosphorylation, ubiquitination/ERAD, and autophagy, indicating a coordinated immune signaling module that integrates protein turnover and autophagic processes.","confidence":"High","size":20,"edges":4,"triangles":0,"max_degree":3,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":4},{"id":"GO:0033209","count":4},{"id":"GO:0002250","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0042098","count":4}]},{"hash":"2121589324696430905","title":"Embryonic Morphogenesis and Cell Cycle Control","description":"The cluster shows strong signals for embryonic development and morphogenesis (neural plate development, limb joint morphogenesis, superior colliculus development) together with cell division regulation (regulation of cell cycle, mitotic cytokinesis) and cytoskeletal/adhesion dynamics (GTPase activity regulation, desmosome assembly, cell migration), suggesting proteins coordinating tissue growth, patterning, and remodeling during development.","confidence":"Medium","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":11},{"id":"GO:0000281","count":10},{"id":"GO:0061324","count":10},{"id":"GO:0036023","count":10},{"id":"GO:0043547","count":10}]},{"hash":"1020198006156795878","title":"Neuronal development and synaptic vesicle trafficking","description":"The dominant terms are brain development and nervous system development, with strong signals for synaptic vesicle exocytosis and ER-to-Golgi vesicle transport, pointing to neuronal growth and synaptic function. The inclusion of JNK signaling and apoptotic terms may reflect stress-responsive pathways in neural cells or shared components, but the core theme ties to neuronal development and synaptic trafficking.","confidence":"High","size":20,"edges":112,"triangles":230,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":8},{"id":"GO:0007399","count":7},{"id":"GO:0071260","count":7},{"id":"GO:0006888","count":6},{"id":"GO:2000300","count":6}]},{"hash":"239343310808174265","title":"Vertebrate development and Wnt signaling","description":"This cluster centers on vertebrate development and signaling, with GO terms for midbrain and pituitary gland development, primitive streak formation, embryonic skeletal system development, and the Wnt signaling pathway. The inclusion of multicellular organism development and single fertilization supports a developmental theme, while the negative regulation of transcription by RNA polymerase II suggests transcriptional control relevant to development. A few terms like visual perception and response to lipopolysaccharide are more peripheral but may reflect broader expression or secondary functions.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0030901","count":6},{"id":"GO:0021983","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0032496","count":5}]},{"hash":"1153711490311584302","title":"Bacterial lipid and secondary metabolite biosynthesis","description":"The terms point to enzymes driving biosynthesis of fatty acids and long-chain lipids, menaquinone and lipoteichoic acid, siderophores, and nonribosomal peptide products, with bioluminescence linking to microbial metabolism. Together they suggest a cluster of proteins involved in lipid and secondary metabolite construction relevant to bacterial cell envelopes and iron acquisition; a plant-specific term appears incidental.","confidence":"High","size":20,"edges":186,"triangles":1072,"max_degree":19,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0006633","count":14},{"id":"GO:0009698","count":11},{"id":"GO:0008218","count":11},{"id":"GO:0043041","count":11},{"id":"GO:0001676","count":11}]},{"hash":"753306810195187039","title":"Ribosome biogenesis and translation regulation","description":"The top GO terms are dominated by translation, ribosomal large subunit assembly, ribosome biogenesis, and translation regulation, pointing to a cluster of proteins involved in ribosome production and control of protein synthesis. A few transcription-related annotations appear, but they are likely secondary to RNA metabolism within this group.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":9},{"id":"GO:0006351","count":2},{"id":"GO:0017148","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0000027","count":2}]},{"hash":"58570899562830414","title":"DNA Repair and Damage Response","description":"The cluster centers on multiple DNA repair pathways (base-excision repair, nucleotide-excision repair, alkylation repair, depurination) and downstream damage responses, indicating a genome maintenance role. Secondary associations include xenobiotic stress and hormone-related responses.","confidence":"High","size":20,"edges":26,"triangles":7,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":5},{"id":"GO:0042493","count":4},{"id":"GO:0006284","count":3},{"id":"GO:0051593","count":3},{"id":"GO:0071320","count":3}]},{"hash":"1206201488366453209","title":"Translation initiation and mRNA processing","description":"The proteins show strong connections to translation initiation and reinitiation (preinitiation complex formation, translational initiation regulation) with supporting roles in mRNA export, splicing, and poly(A) tail regulation, indicating a cohesive function in mRNA maturation and translation control.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":11},{"id":"GO:0001731","count":11},{"id":"GO:0010610","count":8},{"id":"GO:0006446","count":8},{"id":"GO:0075525","count":8}]},{"hash":"1936588868445661699","title":"Ribosome biogenesis and rRNA maturation","description":"Dominant GO terms point to ribosome assembly and rRNA processing (SSU/LSU/5.8S), including maturation and large-subunit biogenesis, indicating a cohesive ribosome production program. Additional signals for spliceosome-mediated mRNA splicing and RNA Pol II transcription, alongside mitotic cell cycle terms, suggest broader coordination with gene expression and cell division, but the strongest signal centers on ribosome biogenesis and rRNA maturation.","confidence":"High","size":20,"edges":52,"triangles":35,"max_degree":13,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0000462","count":4},{"id":"GO:0000070","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0000278","count":3}]},{"hash":"678905570793897698","title":"Rho GTPase\u2013ERK\u2013PI3K Signaling for Cell Motility","description":"The top GO terms center on regulation of Rho GTPase signaling, small GTPase-mediated signaling, ERK cascade regulation, and PI3K pathway activity, all of which promote cytoskeletal rearrangements like lamellipodium assembly and cell movement. Additional growth and development terms (IGF signaling, heart development, smooth muscle proliferation) fit a broader signaling module that influences cell growth and motility, supporting a cohesive theme around cytoskeletal dynamics and migratory signaling.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0043552","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0007264","count":3},{"id":"GO:0030032","count":3}]},{"hash":"1436404334902573774","title":"Cardiovascular Development and Function","description":"The cluster is dominated by heart development (GO:0007507), cardiac muscle contraction (GO:0060048), and angiogenesis (GO:0001525), pointing to a cardiovascular focus; other terms like mitochondrial translation and opsin signaling may reflect broader or multifunctional roles but do not override the main cardiovascular signal.","confidence":"High","size":20,"edges":36,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0070131","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0043547","count":2}]},{"hash":"361192816710682936","title":"Embryonic development and morphogenesis","description":"The top GO terms cover multiple aspects of embryogenesis and tissue/morphogenesis across organs (heart cushion EMT, cartilage morphogenesis, left-right patterning, mesoderm, palate development, hair follicle morphogenesis, placenta/endocrine development, pancreatic cell development). This points to a cohesive theme of developmental processes rather than a single tissue; thus the cluster is best described as embryonic development and morphogenesis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":20},{"id":"GO:0060536","count":20},{"id":"GO:0060972","count":20},{"id":"GO:0003323","count":20},{"id":"GO:0060707","count":20}]},{"hash":"1657494747087125942","title":"tRNA aminoacylation and translation","description":"This cluster is dominated by GO terms for translation and tRNA charging (methionyl-, isoleucyl-, leucyl-, valyl-tRNA aminoacylation) and regulation of translational fidelity, indicating a core function in protein synthesis; a few unrelated terms appear but do not override the overall translation-centric theme.","confidence":"High","size":20,"edges":16,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006450","count":3},{"id":"GO:0030466","count":2},{"id":"GO:0006431","count":2},{"id":"GO:0006428","count":2}]},{"hash":"1279209246123406885","title":"Actin-driven vesicle trafficking in neurons and platelets","description":"This cluster centers on actin cytoskeleton remodeling (lamellipodium and filopodium assembly) and GTPase-driven signaling, which together regulate cell spreading and membrane trafficking. The presence of synaptic vesicle exocytosis and midbrain morphogenesis suggests neural contexts, while platelet activation points to hematopoietic cells as well. The common theme is coordinated actin-based movement and vesicle trafficking across neural and blood cell types, hence the chosen label.","confidence":"High","size":20,"edges":4,"triangles":0,"max_degree":4,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0016079","count":12},{"id":"GO:0030032","count":12},{"id":"GO:0090630","count":12},{"id":"GO:0043314","count":12},{"id":"GO:1904693","count":12}]},{"hash":"1881211726720615303","title":"Blood cell and immune development","description":"The cluster includes terms tied to hematopoiesis and innate immunity, such as megakaryocyte development, platelet formation, neutrophil degranulation, and innate immune response, which suggests a shared theme of blood cell lineage and immune function. Other terms like sensory perception of sound, synaptic depression, heart development, pigmentation regulation, autophagy, and glucose transport appear less directly related and may reflect background annotation or multi-function roles. Overall, the strongest signal centers on blood/immune processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0060292","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0015758","count":3}]},{"hash":"572378584049249160","title":"Neural signaling and sensory perception","description":"The top GO terms cluster around brain and nervous system functions: visual perception/learning, sensory perception of pain, GABAergic synaptic transmission, dopamine regulation, and responses to morphine and prostaglandin signals. Although there are a few terms like heart development, the dominant theme is neural communication and sensory processing in the brain.","confidence":"High","size":20,"edges":69,"triangles":83,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":14},{"id":"GO:0019233","count":14},{"id":"GO:0007507","count":14},{"id":"GO:0043547","count":14},{"id":"GO:0002035","count":14}]},{"hash":"23295795185981760","title":"GPCR-Mediated Cardiac and Visual Responses","description":"Top GO-term enrichment centers on adenylate cyclase-activating GPCR signaling and heart-related regulation (blood pressure, heart contraction), with visual perception and Rho signaling support, suggesting a core theme of GPCR-driven cardiovascular signaling, complemented by vision-related GPCR activity and associated metabolic/cytoskeletal processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":18},{"id":"GO:0035025","count":18},{"id":"GO:0045777","count":18},{"id":"GO:0022900","count":18},{"id":"GO:0042742","count":14}]},{"hash":"1360976231442158913","title":"Thermogenesis and temperature-responsive GPCR signaling","description":"Top GO terms indicate a focus on heat generation and cellular responses to temperature, reinforced by GPCR-mediated signaling and adrenergic regulation of cardiovascular function. This pattern suggests a module of proteins involved in thermogenic responses linked to sympathetic signaling that modulates heart and vascular activity in response to temperature and diet-related cues.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":15},{"id":"GO:0019233","count":15},{"id":"GO:0071502","count":15},{"id":"GO:0033861","count":13},{"id":"GO:0031649","count":13}]},{"hash":"1423185357670115434","title":"Cardiovascular and Neuroimmune GPCR Regulation","description":"Dominant signals are about GPCR signaling and its role in heart contraction (epinephrine/norepinephrine), vascular smooth muscle contraction, GPCR pathway regulation, and neurotransmitter release (dopamine). Dendritic cell chemotaxis shows immune cell movement linked to GPCRs; together these terms suggest a cluster centered on GPCR-mediated signaling impacting cardiovascular, neural, and immune functions.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":20},{"id":"GO:0031649","count":20},{"id":"GO:2000420","count":20},{"id":"GO:0001997","count":20},{"id":"GO:0045745","count":20}]},{"hash":"603163573667642501","title":"Innate immune signaling and neutrophil chemotaxis","description":"The top GO terms cluster around immune defense and signaling: negative regulation of TNF production; positive regulation of neutrophil chemotaxis; defense response to bacterium; cytolysis; and peptidoglycan catabolic processes, all pointing to innate immune activation and inflammatory signaling. There are also terms related to GTPase activity regulation and cell proliferation, suggesting signaling cascades that influence immune responses and tissue homeostasis. A couple of terms related to visual learning and locomotory behavior appear less directly connected and may reflect pleiotropic roles in these proteins or annotation noise. Overall, the dominant pattern supports a theme of immune signaling plus neutrophil-mediated defense.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032720","count":11},{"id":"GO:0090023","count":11},{"id":"GO:0043547","count":11},{"id":"GO:0040015","count":11},{"id":"GO:0007626","count":11}]},{"hash":"2024129701145665200","title":"Adrenergic GPCR-cAMP Signaling and Cardiovascular Regulation","description":"This cluster is dominated by GO terms for adenylate cyclase-activating GPCR signaling and positive regulation of GPCR pathways, with emphasis on adrenergic signaling that modulates heart contraction and blood pressure (e.g., epinephrine/norepinephrine effects). The presence of Rho pathway regulation and energy-related terms (electron transport chain, heat generation) suggests supportive cytoskeletal and metabolic activities in cardiovascular tissues. Overall, the core theme is GPCR-mediated signaling driving cardiovascular function.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":16},{"id":"GO:0035025","count":16},{"id":"GO:0045777","count":16},{"id":"GO:0022900","count":16},{"id":"GO:0008542","count":16}]},{"hash":"43399311301820207","title":"Cardiac Morphogenesis and SA Node Signaling","description":"The top GO terms cluster around heart development and the cardiac conduction system, including right atrium morphogenesis, SA node cell action potential regulation, and SA node cell communication, as well as signaling pathways (Notch, Wnt) involved in cardiac formation and venous endothelial differentiation. This suggests a cohesive function in cardiac development and pacemaker/conduction physiology, rather than unrelated processes. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0071901","count":10},{"id":"GO:0003270","count":9},{"id":"GO:0060843","count":9},{"id":"GO:0016055","count":9},{"id":"GO:0003213","count":9}]},{"hash":"1997397316250867442","title":"Ubiquitination-Mediated Antiviral Immunity","description":"The cluster is dominated by GO terms for ubiquitination (K63-linked ubiquitination, ubiquitin-dependent protein catabolic process, autoubiquitination) and antiviral/immune functions (defense and innate/adaptive immune responses, suppression of viral release, negative regulation of RIG-I signaling), suggesting proteins that regulate antiviral defense through ubiquitin signaling and RIG-I pathway modulation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0070534","count":10},{"id":"GO:1902187","count":10},{"id":"GO:0042787","count":10},{"id":"GO:0002250","count":9},{"id":"GO:0016567","count":9}]},{"hash":"120703712580588294","title":"Neurotransmitter GPCR Signaling in Cardiovascular Regulation","description":"This cluster's top GO terms largely point to GPCR signaling modulated by neurotransmitters (serotonin, dopamine) with downstream effects on adenylate cyclase and GTPase activity, and physiological readouts such as heart contraction and vascular smooth muscle contraction. While there are also immune-related terms, the dominant theme is neurotransmitter-driven GPCR signaling linked to cardiovascular regulation, supporting this label.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":20},{"id":"GO:0031649","count":20},{"id":"GO:2000420","count":20},{"id":"GO:0001997","count":20},{"id":"GO:0045745","count":20}]},{"hash":"944714881677320838","title":"LPS/Xenobiotic-induced inflammation with vascular signaling","description":"This cluster centers on innate immune responses to xenobiotics and LPS (response to xenobiotic stimulus, response to lipopolysaccharide) and includes monocyte chemotaxis, fever-related heat generation, and modulation of GPCR signaling, along with vascular and cardiac regulation (vascular smooth muscle contraction, heart contraction regulation). Together these terms suggest a cohesive theme of inflammation coupled with vascular/cardiac signaling responses, rather than a purely metabolic or structural protein set.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042493","count":20},{"id":"GO:0032496","count":20},{"id":"GO:0008284","count":20},{"id":"GO:0090026","count":20},{"id":"GO:0033861","count":19}]},{"hash":"933380147712274217","title":"Neural signaling with thermogenic and inflammatory cues","description":"The top GO terms span neural signaling (visual learning, dopamine receptor signaling, pain perception) and physiological responses tied to temperature and metabolism (thermogenesis, heat generation) as well as inflammatory pathways (prostanoid response, IL-8 production). While the terms are diverse, they collectively point to coordinated neural-regulatory control of metabolic and inflammatory states, suggesting a broad but related theme rather than a single precise function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":11},{"id":"GO:2000484","count":10},{"id":"GO:0071380","count":10},{"id":"GO:0008283","count":10},{"id":"GO:0002024","count":10}]},{"hash":"526250634995483130","title":"Adrenergic GPCR Signaling in Heart and Vascular Smooth Muscle","description":"The top GO terms center on calcium release into the cytosol, GPCR signaling, and regulation of heart contraction by epinephrine/norepinephrine, as well as smooth muscle contraction in vessels. This points to adrenergic GPCR pathways governing cardiac and vascular function, with downstream calcium and cAMP/GTPase signaling. A few terms (like dendritic cell chemotaxis) may be less directly related but still fall under GPCR-driven processes, reinforcing an overall cardiovascular GPCR-calcium signaling theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":20},{"id":"GO:0033861","count":19},{"id":"GO:0031649","count":19},{"id":"GO:2000420","count":19},{"id":"GO:0001997","count":19}]},{"hash":"666936150763152614","title":"Cytoskeleton dynamics and Rho GTPase signaling","description":"The cluster\u2019s top GO terms cluster around actin cytoskeleton organization, regulation of Rho GTPase signaling, and GTPase activation, plus related processes like vesicle trafficking in neurons. Developmental hematopoietic terms (hemopoiesis, embryonic development) can be linked to cytoskeletal regulation of cell movement and division, supporting a theme of cytoskeleton remodeling coordinated by Rho/GTPases. This suggests a cohesive function centered on cytoskeleton dynamics and GTPase signaling rather than disparate processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030097","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0051232","count":4},{"id":"GO:0001701","count":4},{"id":"GO:0010572","count":3}]},{"hash":"770094771488555573","title":"Cardiovascular GPCR Signaling and Vascular Tone","description":"The top GO terms point to GPCR signaling regulation and downstream effects such as adenylate cyclase modulation, heart contraction modulation by catecholamines, and vascular smooth muscle contraction, indicating a core role in GPCR-driven cardiovascular control. Immune/neural signaling terms (dendritic cell chemotaxis, dopamine secretion) appear as cross-talk within GPCR pathways but do not outweigh the cardiovascular-focused signals. Overall, this cluster appears centered on GPCR-mediated regulation of cardiovascular function with related signaling interactions.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":20},{"id":"GO:0031649","count":20},{"id":"GO:2000420","count":20},{"id":"GO:0001997","count":20},{"id":"GO:0045745","count":20}]},{"hash":"1570232859398710928","title":"Negative regulation of Rac/Rho signaling and actin dynamics","description":"The top GO terms cluster around inhibiting Rac/Rho small GTPase signaling, which governs actin cytoskeleton organization, plus endothelial-related processes like lumen extension and vessel remodeling. Together they point to suppressed cytoskeletal remodeling and GTPase signaling in vascular/endothelial contexts; a single outlier term (sensory perception of sound) is less connected but does not redefine the main theme.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043314","count":5},{"id":"GO:0060313","count":5},{"id":"GO:0051497","count":5},{"id":"GO:0097498","count":5},{"id":"GO:0035021","count":5}]},{"hash":"1832360233510435836","title":"Unknown","description":"Top GO terms span development (atrial septum morphogenesis, hippocampus development), immune processes (IgA isotype switching, leukocyte tethering or rolling), transcription/epigenetic regulation (DNA-templated transcription, histone methylation), signaling (Rap), cell adhesion, and intracellular transport. The broad and disparate set of functions provides no single cohesive theme to define a specific label, so a precise, representative name cannot be assigned with confidence.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010452","count":2},{"id":"GO:0003290","count":2},{"id":"GO:0048298","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0003289","count":2}]},{"hash":"2036423975495763445","title":"Caveolae-Mediated Signaling and Cytoskeleton","description":"Proteins in this cluster are enriched for caveolin-mediated endocytosis and caveola assembly, actin cytoskeleton remodeling (GTPase regulation), and multiple signaling pathways (insulin receptor, angiotensin, TGF-beta). This suggests a core theme of membrane microdomain\u2013driven signaling coordinating cytoskeletal dynamics, with cardiovascular-related processes and broader signaling contexts. Some terms (uterus development, B cell signaling) are less directly related but do not override the caveola/cytoskeleton signal focus.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060065","count":4},{"id":"GO:0031532","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0086098","count":4}]},{"hash":"1291351340855526764","title":"ERAD and Proteostasis Regulators","description":"The top terms center on ubiquitin-mediated ER-associated degradation (ERAD), maintenance of unfolded proteins in the ER, deubiquitination, and regulation of autophagy and ER-stress\u2013related apoptosis. Together they suggest a cohesive role in ER proteostasis and quality control of secretory pathway proteins; some outliers may reflect incidental annotations.","confidence":"Medium","size":19,"edges":167,"triangles":903,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":6},{"id":"GO:1904378","count":5},{"id":"GO:0033132","count":5},{"id":"GO:0016579","count":5},{"id":"GO:1901097","count":5}]},{"hash":"2279147424770011877","title":"Neural development and sensory differentiation","description":"The top GO terms cluster around neural lineage specification and sensory neuron differentiation, including neuroblast fate determination, neural retina development, GABAergic neuron differentiation in basal ganglia, noradrenergic neuron fate commitment, and auditory receptor cell fate specification, with transcription by RNA polymerase II supporting broad developmental programs. A few terms about morphogenesis and circadian entrainment are peripheral, but the dominant theme is neural/sensory development. ","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":19},{"id":"GO:0007400","count":18},{"id":"GO:0048743","count":18},{"id":"GO:0003407","count":18},{"id":"GO:0061682","count":18}]},{"hash":"1462192557374207703","title":"Embryonic organogenesis","description":"This cluster centers on developmental processes across multiple organ systems (eye, digestive tract, pancreas, lung, kidney) and includes transcription-related terms. The prominent morphogenesis terms, especially embryonic eye morphogenesis and eye development, point to a broad embryonic organogenesis program rather than a single pathway.","confidence":"Medium","size":19,"edges":55,"triangles":26,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0006366","count":9},{"id":"GO:0048048","count":9},{"id":"GO:0043010","count":8},{"id":"GO:0048557","count":8}]},{"hash":"338747686492131466","title":"Neuronal development and vesicle trafficking","description":"The top GO terms cluster around neural development (hippocampus development, regulation of axonogenesis, neuron survival) and synaptic/vesicle processes (vesicle docking, protein localization to the plasma membrane), suggesting proteins involved in neuronal maturation and synaptic vesicle trafficking. While a few terms are more general, the dominant themes point to neural development with a vesicle transport component.","confidence":"High","size":19,"edges":65,"triangles":78,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021766","count":16},{"id":"GO:0043525","count":16},{"id":"GO:0050771","count":15},{"id":"GO:0071260","count":15},{"id":"GO:0032889","count":15}]},{"hash":"2214239306693286180","title":"Nuclear mRNA processing and splicing regulation","description":"This cluster shows strong enrichment for post-transcriptional RNA processing in the nucleus, especially mRNA splicing via the spliceosome, regulation of alternative splicing, mRNA polyadenylation and tail shortening, mRNA export, and general RNA modification. The convergence on these processes suggests a cohesive module of factors coordinating RNA maturation and stability, including stress-responsive regulation.","confidence":"High","size":19,"edges":168,"triangles":919,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":16},{"id":"GO:0006378","count":16},{"id":"GO:0000381","count":15},{"id":"GO:0048026","count":15},{"id":"GO:0031047","count":15}]},{"hash":"177195254969150345","title":"Cerebellar development and neural signaling","description":"This cluster is dominated by GO terms related to cerebellar development and neural signaling, such as cerebellar cortex formation and Bergmann glial cell differentiation, along with regulation of axon regeneration. Insulin receptor signaling and other metabolic/immune signaling terms appear among the top terms, suggesting broader signaling roles, but the cerebellar development and neural connectivity terms are the strongest theme.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0008286","count":15},{"id":"GO:0048679","count":15},{"id":"GO:0050852","count":15},{"id":"GO:0021697","count":15},{"id":"GO:0008285","count":15}]},{"hash":"1909787792508864541","title":"Auditory mechanosensation and vestibular function","description":"Enriched for hearing and balance processes, with terms like auditory receptor cell development, detection of mechanical stimulus involved in sensory perception of sound, sensory perception of sound, and vestibular reflex, indicating a shared role in auditory perception and equilibrium. Some terms (calcium transport, zinc homeostasis) appear peripheral to the main theme.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060117","count":3},{"id":"GO:1903169","count":3},{"id":"GO:0055069","count":3},{"id":"GO:0050910","count":3},{"id":"GO:1902041","count":3}]},{"hash":"1826792375917234048","title":"RNA splicing and mRNA processing","description":"This cluster is dominated by GO terms related to spliceosome-mediated and alternative mRNA splicing, mRNA export, polyadenylation regulation, and translation initiation, indicating a cohesive group focused on post-transcriptional RNA processing and gene expression control.","confidence":"High","size":19,"edges":164,"triangles":859,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":11},{"id":"GO:0031047","count":11},{"id":"GO:0002188","count":9},{"id":"GO:0001731","count":9},{"id":"GO:1901407","count":8}]},{"hash":"2134059671624132441","title":"Organ Morphogenesis and Lipid Metabolism","description":"This cluster centers on developmental processes across multiple organs (heart, pancreas, limbs) together with lipid-related regulation (fat differentiation, cholesterol homeostasis, lipid transport) and retinoic acid signaling, suggesting a theme of organ morphogenesis coupled with metabolic regulation.","confidence":"High","size":19,"edges":29,"triangles":12,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0045444","count":6},{"id":"GO:0035264","count":6},{"id":"GO:0006351","count":5},{"id":"GO:0035116","count":4}]},{"hash":"1949803742297284441","title":"ERAD-Linked Deubiquitination","description":"Top GO terms are dominated by ubiquitin-related deubiquitination across several linkages (K29, K6, K11, K48) and by ER-associated degradation (ERAD) processes, pointing to a cohesive role in ubiquitin-dependent proteostasis and ER quality control, with transcriptional regulation signals likely reflecting downstream effects of deubiquitinases. Overall, the cluster appears to group proteins involved in removing ubiquitin from substrates and managing unfolded proteins in the ER.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":7},{"id":"GO:0035523","count":7},{"id":"GO:0044313","count":7},{"id":"GO:1904378","count":6},{"id":"GO:1903070","count":5}]},{"hash":"643988740020451645","title":"Secretory vesicle trafficking and exocytosis regulation","description":"Based on the enriched GO terms, the cluster centers on vesicle trafficking and exocytosis in secretory pathways, including synaptic vesicle exocytosis, Golgi to plasma membrane transport, and insulin secretion, with membrane composition (phospholipid homeostasis) and cytoskeletal regulation (Rho signaling) supporting these processes. While a few terms are broader or indirect, the dominant theme ties to secretory vesicle handling and membrane fusion, making this a cohesive functional cluster.","confidence":"High","size":19,"edges":164,"triangles":856,"max_degree":18,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0010796","count":5},{"id":"GO:0031384","count":5},{"id":"GO:2000300","count":5},{"id":"GO:0032024","count":5},{"id":"GO:0035023","count":5}]},{"hash":"814433299689635276","title":"Vertebrate Developmental Signaling","description":"Reasoning: The top GO terms cluster around developmental signaling and morphogenesis in vertebrates. Hedgehog (smoothened) signaling and ROBO guidance point to patterning and axon/neurite navigation; nervous system development, kidney development, nephric duct morphogenesis, and regulation of dendrite development indicate organogenesis and neural wiring. Additional RTK signaling, IL-27 signaling, and T cell receptor signaling reflect broader cell communication networks that accompany development and immune interactions. Overall, the shared theme is signaling pathways shaping tissue development and morphogenesis rather than a single isolated process.","confidence":"High","size":19,"edges":145,"triangles":613,"max_degree":18,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007224","count":11},{"id":"GO:0035385","count":11},{"id":"GO:0007399","count":11},{"id":"GO:0001822","count":11},{"id":"GO:0050852","count":11}]},{"hash":"960764451828235577","title":"Myogenesis and neural development with cytokine signaling","description":"This cluster is enriched for terms related to muscle formation (myoblast fusion, myoblast differentiation, myelination) and peripheral nervous system development (PNS development, clustering of voltage-gated sodium channels), along with signaling pathways such as Hedgehog (smoothened), Rho/STAT signaling, and cytokine signals (interleukin-27, Th2 cytokine production). Together, these suggest a core function in coordinating muscle and nerve development with immune signaling cross-talk.","confidence":"Medium","size":19,"edges":167,"triangles":904,"max_degree":18,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":10},{"id":"GO:0042517","count":9},{"id":"GO:0007520","count":9},{"id":"GO:0070106","count":8},{"id":"GO:0035745","count":8}]},{"hash":"526070230968734563","title":"Spliceosome Assembly Proteins","description":"The top GO terms are dominated by spliceosomal snRNP assembly and the generation of catalytic spliceosome steps, indicating the cluster mainly contains proteins involved in RNA splicing. The neural development and immune signaling terms likely reflect broader, multifunctional roles of some splicing factors rather than a primary cluster theme. ","confidence":"High","size":19,"edges":34,"triangles":9,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0000387","count":3},{"id":"GO:0000349","count":3},{"id":"GO:0007413","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0022038","count":2}]},{"hash":"739594758728330211","title":"Immune Signaling and Defense","description":"The top GO terms cluster around immune signaling and defense responses, including innate and adaptive immunity (innate immune response, defense response to Gram-positive bacteria, T cell receptor signaling, IL-1\u2013mediated signaling) and inflammatory pathways (positive regulation of JNK cascade). While a couple of terms like mRNA processing appear, the dominant theme is immune activation and host defense.","confidence":"High","size":19,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0090502","count":4},{"id":"GO:0046330","count":3},{"id":"GO:0070498","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0045444","count":3}]},{"hash":"1697787419284383411","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":86,"triangles":182,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":18},{"id":"GO:0050709","count":15},{"id":"GO:0019236","count":15},{"id":"GO:0007117","count":15},{"id":"GO:0010224","count":15}]},{"hash":"98045405963191067","title":"Lipid and sulfur metabolism with hormone response","description":"The top GO terms cluster around lipid metabolism (fatty acid oxidation; cholesterol biosynthetic process) and sulfur metabolism (L-cysteine biosynthesis; hydrogen sulfide biosynthesis), with additional signaling responses to hormones (FSH stimulus; peptide hormone stimulus) and stress (response to toxic substance). This suggests a metabolic module that links lipid/sulfur pathways to regulatory hormone responses, though some terms (e.g., subtelomeric heterochromatin formation) may be less connected. ","confidence":"Medium","size":19,"edges":10,"triangles":3,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0009636","count":8},{"id":"GO:0019395","count":6},{"id":"GO:0071372","count":6},{"id":"GO:0006695","count":6},{"id":"GO:0071375","count":6}]},{"hash":"2121494331028338226","title":"Vertebrate embryonic organogenesis and sensory development","description":"The top GO terms cluster around development of multiple vertebrate organs and sensory structures\u2014cartilage, midbrain, hindlimb morphogenesis, inner ear, pharyngeal system, odontogenesis, and visual perception\u2014plus regulation of transcription, suggesting coordinated developmental gene regulation across organs rather than a single pathway. This points to a broad theme of embryonic organ formation and tissue differentiation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0051216","count":6},{"id":"GO:0030901","count":6},{"id":"GO:0035116","count":5},{"id":"GO:0048839","count":5}]},{"hash":"2179201123766205494","title":"Translation machinery and tRNA aminoacylation","description":"This cluster is dominated by GO terms for translation, ribosome assembly, and various tRNA aminoacylation events (histidine, seryl, threonyl) in both cytoplasmic and mitochondrial contexts, pointing to a cohesive group of proteins involved in protein synthesis and tRNA charging. Some mitochondrial-specific and related processes appear as secondary signals, but the core theme is translation and tRNA charging.","confidence":"High","size":19,"edges":152,"triangles":697,"max_degree":18,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":16},{"id":"GO:0000027","count":4},{"id":"GO:0002181","count":3},{"id":"GO:1903833","count":3},{"id":"GO:0070584","count":2}]},{"hash":"533680048866453557","title":"DNA Methylation and Epigenetic Regulation","description":"This cluster is dominated by GO terms tied to cytosine C5 methylation and broader DNA methylation processes, including methylation-dependent heterochromatin formation and epigenetic programming of gene expression. The presence of both methylation-specific terms (including obsolete ones) and a DNA restriction-modification reference suggests proteins connected to DNA methylation and its role in epigenetic regulation, rather than protein-protein interaction networks. Confidence: Medium","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090116","count":3},{"id":"GO:0009307","count":3},{"id":"GO:0043046","count":3},{"id":"GO:0006346","count":3},{"id":"GO:0010424","count":3}]},{"hash":"717505576084857014","title":"Neuronal GPCR signaling and synaptic plasticity","description":"The top GO terms highlight GPCR-related signaling, GTPase activation, regulation of ephrin signaling, receptor localization to the synapse, and synaptic plasticity\u2014points to neuronal signal transduction and synaptic regulation as the core function of this cluster. Some terms touch on sensory structures (ear, lens) that might reflect broader sensory annotations, but the dominant theme is signaling at neural synapses and plasticity.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007205","count":7},{"id":"GO:0090630","count":6},{"id":"GO:0007605","count":5},{"id":"GO:1901187","count":5},{"id":"GO:1900383","count":5}]},{"hash":"937040946293918556","title":"Neurodevelopment with innate immune signaling","description":"Based on the top GO terms, the cluster centers on nervous system development and related processes (nervous system development, axonal fasciculation, myelination, synapse assembly, cranial skeleton morphogenesis, heart development), suggesting a neurodevelopmental theme. The presence of immune-related terms (response to exogenous dsRNA, lipopolysaccharide signaling, defense response to Gram-positive bacterium) indicates concurrent engagement of innate immune pathways. Together, these points imply proteins involved in neural development that also interface with immune signaling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043330","count":12},{"id":"GO:0031663","count":11},{"id":"GO:0050830","count":11},{"id":"GO:0071222","count":11},{"id":"GO:0048701","count":10}]},{"hash":"529214994560205266","title":"Neural vision and dopaminergic signaling","description":"The cluster is dominated by GO terms for visual perception and visual learning, together with dopaminergic synaptic transmission and cocaine-related behavioral responses, pointing to brain-related sensory processing and dopamine signaling. Additional terms for ERK signaling and GTPase regulation reflect downstream neuronal signaling; other terms like prostaglandin response and macrophage chemotaxis appear less central. Overall, a coherent theme around neural visual processing and dopamine-driven signaling.","confidence":"High","size":19,"edges":126,"triangles":387,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":15},{"id":"GO:0008542","count":15},{"id":"GO:0007601","count":15},{"id":"GO:0010759","count":15},{"id":"GO:0048148","count":15}]},{"hash":"946737260053477213","title":"Ribosome Biogenesis and Translation Machinery","description":"This cluster is dominated by GO terms for translation, ribosome biogenesis, and rRNA maturation/modification (e.g., translation, ribosome biogenesis, SSU-rRNA maturation, rRNA and snRNA pseudouridine synthesis, ribosomal subunit biogenesis). These point to a core function in ribosome assembly and protein synthesis, with translation reinitiation as an additional related process. A few developmental terms appear (neural tube closure, gastrulation, single fertilization) likely reflecting pleiotropy or broad expression, but the strongest signal is clearly the ribosome/translation program.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":14},{"id":"GO:0042254","count":11},{"id":"GO:0000462","count":7},{"id":"GO:0007338","count":7},{"id":"GO:0042273","count":5}]},{"hash":"2047717277374502651","title":"Signal transduction and sensory perception","description":"The top GO terms point to broad signaling activities (phosphatidylinositol-mediated signaling, GPCR acetylcholine receptor signaling, calcium ion transport) and sensory perception (sound and vision), with additional muscle development and immune-related terms. The absence of edges suggests these proteins may be functionally diverse rather than part of a single tight module, but the recurring emphasis on signaling and sensory-related processes justifies this label.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048015","count":2},{"id":"GO:0006816","count":2},{"id":"GO:0007213","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0007605","count":2}]},{"hash":"579046695745364573","title":"Adaptive and innate immune signaling","description":"The cluster is strongly enriched for GO terms related to immune signaling and defense, including B cell receptor signaling, B cell affinity maturation, dendritic cell differentiation, and type I interferon signaling, along with inflammatory and cell-adhesion processes. This points to a central theme of immune cell communication and activation spanning adaptive (B cells) and innate (interferon signaling, dendritic cells) immunity. A few terms (e.g., cuticle formation) are outliers, likely due to annotation cross-talk, but do not override the dominant immune theme.","confidence":"High","size":19,"edges":18,"triangles":7,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050853","count":13},{"id":"GO:0002344","count":13},{"id":"GO:0006968","count":13},{"id":"GO:0060337","count":13},{"id":"GO:1904597","count":11}]},{"hash":"1967221990541170390","title":"Mitochondrial Electron Transport and ATP Synthesis","description":"The top GO terms cluster around mitochondrial respiration, including NADH dehydrogenase to ubiquinone, cytochrome c to oxygen, proton translocation, and ATP synthase complex assembly, pointing to a cohesive role in the mitochondrial electron transport chain and ATP production. A few outliers (photosynthesis, chromatin assembly) are present but do not override the dominant respiratory theme.","confidence":"High","size":19,"edges":154,"triangles":716,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0042775","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0019684","count":2},{"id":"GO:0006810","count":2}]},{"hash":"355337344125677172","title":"Thermogenesis and Temperature Response","description":"The cluster is dominated by GO terms related to heat production and temperature response (diet-induced thermogenesis, cellular response to temperature stimulus, heat generation) along with mitochondrial energy processes (electron transport chain) and signaling pathways (adenylate cyclase activation via GPCRs) that are known to drive thermogenic activity. While there are some peripheral terms related to immune signaling and blood pressure, the core signal points to temperature-associated energy metabolism and heat production.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":15},{"id":"GO:0019233","count":15},{"id":"GO:0071502","count":15},{"id":"GO:0048245","count":14},{"id":"GO:0007190","count":14}]},{"hash":"537280453574852897","title":"Cardiac GPCR Adrenergic Signaling","description":"Top terms point to GPCR-mediated signaling that controls heart contraction and vascular tone (adrenergic signaling via epinephrine/dopamine receptors; prostaglandin response; blood pressure regulation). The electron transport chain term hints at cardiac energy metabolism, supporting a cardiac/energy theme. Overall, this cluster appears to reflect cardiac GPCR-driven signaling and related metabolic activity.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":12},{"id":"GO:0008283","count":12},{"id":"GO:0045777","count":12},{"id":"GO:0022900","count":12},{"id":"GO:0010579","count":12}]},{"hash":"1540241608878960027","title":"Immune activation: B cells, phagocytosis, antigen presentation","description":"This cluster is enriched for adaptive immune processes (B cell receptor signaling, positive regulation of B cell activation) and innate/antigen-handling pathways (phagocytosis, innate immune response, complement activation) with evidence of antigen processing and presentation via MHC class I. The combination suggests a coordinated immune-activation module bridging B cell signaling, phagocytic activity, and antigen presentation.","confidence":"High","size":19,"edges":33,"triangles":14,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006911","count":11},{"id":"GO:0050853","count":11},{"id":"GO:0045087","count":10},{"id":"GO:0050871","count":10},{"id":"GO:0006910","count":10}]},{"hash":"2304046730759103386","title":"Cardiac development and SA node signaling","description":"The top terms point to heart-related functions, including Notch pathway involvement in regulating heart-field cardioblast proliferation, SA node cell action potential regulation, and SA node communication, along with developmental cell migration. While some terms (oligodendrocyte differentiation, thermoception) seem less directly connected, the dominant theme across the cluster is cardiac development and pacemaker signaling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097284","count":5},{"id":"GO:0048709","count":5},{"id":"GO:0071260","count":5},{"id":"GO:0044707","count":4},{"id":"GO:2000340","count":4}]},{"hash":"858549021762772137","title":"Epithelial polarity and tight junction remodeling","description":"Most of the top terms describe epithelial cell polarity (establishment of epithelial cell polarity) and tight junction assembly (bicellular tight junction assembly), along with actin cytoskeleton reorganization (actin filament bundle assembly, cell migration). While there are some transcription-related terms, the dominant theme is epithelial junctions and polarity coupled to cytoskeletal dynamics, justifying a label focused on epithelial polarity and junction assembly.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0090162","count":3},{"id":"GO:0032088","count":3}]},{"hash":"1616655089761968235","title":"ECM remodeling and cell-adhesion signaling","description":"Based on the GO terms, the cluster centers on extracellular matrix (ECM) organization and remodeling, cell-matrix adhesion, and related signaling (TGF-beta production, GPCR signaling) that influence neural lineage decisions (astrocyte differentiation) and nitric oxide production. These themes suggest proteins involved in ECM dynamics and cell-ECM communication in neural/vascular contexts, despite a few outliers like memory-related terms. Confidence: Medium","confidence":"","size":19,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071636","count":3},{"id":"GO:1901201","count":3},{"id":"GO:0048711","count":3},{"id":"GO:0045429","count":3},{"id":"GO:0007596","count":3}]},{"hash":"416489855783666188","title":"DNA Repair and Telomere Regulation","description":"This cluster is enriched with terms centered on genome stability, notably DNA repair and telomere maintenance/capping (e.g., positive regulation of telomere maintenance via telomerase, positive regulation of telomere capping, and DNA repair). Additional terms touch on chromatin regulation (histone ubiquitination) and proteasomal degradation, supporting a core theme of genome integrity and chromatin dynamics. Some development or signaling terms (Wnt, angiogenesis) appear secondary to this primary theme.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0032212","count":3},{"id":"GO:0006281","count":3},{"id":"GO:0045071","count":2},{"id":"GO:1904355","count":2},{"id":"GO:0090263","count":2}]},{"hash":"678318104854608637","title":"Ubiquitin-Dependent Regulation and Chromatin Modification","description":"Top GO terms cluster around ubiquitin-dependent protein catabolic processes, histone modification and chromatin-related turnover, plus NF-\u03baB pathway regulation and apoptosis. This points to a shared function in ubiquitin-mediated control of protein stability and chromatin state, influencing transcription and cell survival, which justifies a name centered on ubiquitin-dependent regulation and chromatin modification.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:1903721","count":10},{"id":"GO:0009048","count":10},{"id":"GO:2000620","count":10},{"id":"GO:0036205","count":10}]},{"hash":"1241545920549616345","title":"Embryonic Development and Morphogenesis","description":"The top GO terms point to broad morphogenetic and organ-formation processes across multiple lineages (mouth roof formation, heart-associated EMT, cartilage, left-right patterning, pancreas development, mesoderm formation, placenta-related differentiation, hair follicle morphogenesis, endocrine system development). This pattern suggests a cohesive theme of embryonic development and tissue morphogenesis rather than a single pathway, making a developmental-morphogenesis label appropriate.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":16},{"id":"GO:0003198","count":15},{"id":"GO:0060536","count":15},{"id":"GO:0060972","count":15},{"id":"GO:0003323","count":15}]},{"hash":"983162978851947331","title":"Cell Division and Intracellular Transport","description":"Top GO terms center on cell cycle events (meiotic spindle elongation, mitotic nuclear membrane reassembly, regulation of meiotic cell cycle in oocytes) and various intracellular transport/regulation processes (vesicle-mediated transport, ribosomal protein import into nucleus, mRNA transport, GTPase/kinase activity regulation, MAPK inactivation). This points to a cluster of proteins involved in coordinating division with trafficking and signaling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"vesicle-mediated transport","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0016192","count":3},{"id":"GO:0006610","count":2},{"id":"GO:1903538","count":2},{"id":"GO:0051028","count":2}]},{"hash":"965048741000748049","title":"Signaling and Telomere Regulation Proteins","description":"The top GO terms show involvement in multiple signaling pathways (GPCR, Wnt, LPS) as well as telomere-related processes (localization to telomeric regions, telomere capping), with some links to cytoskeletal dynamics and synaptic regulation. This suggests a broad role in signaling that interfaces with telomere maintenance and nuclear localization, rather than a single, cohesive pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0048745","count":3},{"id":"GO:0051497","count":3},{"id":"GO:0070198","count":3},{"id":"GO:0031666","count":3}]},{"hash":"2070410741179241317","title":"Embryonic organ development","description":"The top GO terms point to development and morphogenesis across multiple organs (skin, brain, spinal cord, kidney), suggesting a shared theme of embryonic organ development. Some terms reference trafficking or immune regulation, but the dominant signal is diverse developmental processes, not a single pathway or function. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061436","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0021987","count":3},{"id":"GO:0097284","count":2},{"id":"GO:0034498","count":2}]},{"hash":"541216407184120888","title":"Nuclear transport and chromatin localization during cell cycle","description":"This cluster centers on nuclear processes: ribosomal protein import into the nucleus, establishment of protein localization to chromatin, and mRNA transport, together with meiotic/mitotic cell cycle events such as spindle elongation and nuclear membrane reassembly. The presence of regulatory terms (kinase activity, GTPase activity, desumoylation) further supports a theme of cell-cycle\u2013related nuclear regulation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0071169","count":4},{"id":"GO:0006610","count":4},{"id":"GO:1903538","count":4},{"id":"GO:0051028","count":4}]},{"hash":"965173640780787871","title":"Developmental morphogenesis and tissue differentiation","description":"Top GO terms cluster around development and tissue formation (skeletal muscle development, cartilage morphogenesis, left/right patterning, endocrine system development, EMT in heart cushion formation, placental/trophoblast differentiation). This suggests a developmental/morphogenetic theme. A few items (response to morphine, B cell signaling, spliceosome) are less connected to morphogenesis and may reflect broader cellular processes. Overall, the label captures the dominant pattern in the data.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060536","count":3}]},{"hash":"2176573752307576589","title":"Gene Expression Regulation and Development","description":"The top GO terms point to regulatory roles across transcription, RNA processing, ubiquitination, and translation initiation, with additional emphasis on developmental processes (neural crest migration, ureteric bud morphogenesis, germ-line cyst formation) and adaptive immune response. Together, they suggest a cluster of proteins involved in broad regulation of gene expression and cellular differentiation rather than a single pathway. The absence of edges indicates these proteins are not tightly interconnected in this dataset. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033081","count":2},{"id":"GO:0090190","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0001755","count":2},{"id":"GO:0002250","count":2}]},{"hash":"1285132004531871211","title":"Embryonic morphogenesis and organ development","description":"The top GO terms point to broad developmental and morphogenetic processes across tissues (endocardial cushion/heart, cartilage, palate, mesoderm, left-right patterning, hair follicles, endocrine system), indicating a cluster of proteins involved in embryonic development and organogenesis rather than a single specific pathway. The presence of regulatory terms like transcriptional repression fits a developmental regulatory context.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":13},{"id":"GO:0060536","count":13},{"id":"GO:0000122","count":13},{"id":"GO:0060972","count":13},{"id":"GO:0003323","count":13}]},{"hash":"734963224872368883","title":"Vertebrate development and stress signaling","description":"The top GO terms point to vertebrate tissue development (Schwann cell development, tricuspid valve morphogenesis, lung-associated mesenchyme development) along with signaling and stress responses (MAPK cascade, apoptotic process, response to toxic substance). Some terms appear unusual (plant hormone signaling), likely due to annotation noise, but the dominant theme is development plus stress-related signaling in vertebrate tissues.","confidence":"Medium","size":18,"edges":109,"triangles":315,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070640","count":18},{"id":"GO:0072709","count":18},{"id":"GO:0000196","count":18},{"id":"GO:0060484","count":18},{"id":"GO:0006915","count":18}]},{"hash":"956685908329726316","title":"Embryonic neural and sensory organ development","description":"The cluster is dominated by GO terms related to early brain development (forebrain, metencephalon, midbrain-hindbrain boundary), sensory organ formation (eye, inner ear), and associated morphogenesis, indicating a coherent theme of embryonic neural and sensory organ formation.","confidence":"High","size":18,"edges":30,"triangles":18,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":18},{"id":"GO:0022037","count":17},{"id":"GO:0030917","count":17},{"id":"GO:0043010","count":17},{"id":"GO:0001757","count":17}]},{"hash":"833641718349485761","title":"Developmental and Immune Signaling","description":"The cluster includes immune-related terms (innate immune response, B cell receptor signaling, B cell differentiation) alongside developmental and signaling pathways (heart development, branching morphogenesis in mammary gland, retinoic acid response, insulin signaling) and endocytic processes, suggesting a set of proteins that participate in cross-talk between development, immunity, and metabolism rather than a single narrow function.","confidence":"Medium","size":18,"edges":24,"triangles":0,"max_degree":11,"top_function":"DNA repair","top_go_terms":[{"id":"GO:2000251","count":13},{"id":"GO:0045087","count":13},{"id":"GO:0060444","count":13},{"id":"GO:0006915","count":12},{"id":"GO:0071300","count":12}]},{"hash":"695458717998387814","title":"Neural signaling and apoptosis regulation","description":"The cluster shows enrichment in IP3 (inositol trisphosphate) biosynthesis and phosphorylation, plus terms tied to neural development and behavior (cerebellum morphogenesis, grooming behavior), indicating a module focused on neural signaling and development. The presence of mitochondrial depolarization regulation and apoptotic process terms suggests integration with cell survival and stress responses, implying these proteins coordinate neural signaling with apoptotic/mitochondrial pathways rather than a single pathway. ","confidence":"Medium","size":18,"edges":23,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":5},{"id":"GO:0001878","count":2},{"id":"GO:0060988","count":2},{"id":"GO:0051902","count":2},{"id":"GO:0021587","count":2}]},{"hash":"910983024649870423","title":"ER protein quality control and stress response","description":"The GO terms cluster around endoplasmic reticulum processes: protein folding in the ER, ER-associated degradation (ERAD), misfolded protein transport, and ER-stress\u2013driven regulation of translation, with notes on protein export from the nucleus. Together these indicate a coherent theme of ER quality control under stress. Nuclear transport and DNA replication terms appear only peripherally.","confidence":"High","size":18,"edges":78,"triangles":227,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030433","count":10},{"id":"GO:0035719","count":9},{"id":"GO:1900035","count":9},{"id":"GO:0070843","count":9},{"id":"GO:0034975","count":9}]},{"hash":"927367712004178007","title":"Peripheral nerve development and myelination","description":"The dominant GO terms focus on peripheral nervous system development, myelination, and axon organization (paranode localization, Na channel clustering, nerve impulse transmission), with Hedgehog signaling and cytokine signaling as contextual supports, suggesting a cluster centered on PNS myelinating glia\u2013axon interactions.","confidence":"High","size":18,"edges":128,"triangles":493,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0070106","count":11},{"id":"GO:0042517","count":11},{"id":"GO:0035745","count":10},{"id":"GO:0007224","count":9},{"id":"GO:0007422","count":9}]},{"hash":"728088332118838230","title":"Immune cell metabolism and proliferation","description":"The top GO terms cluster around core metabolic pathways (glutamine, pyruvate, GMP, PRPP biosynthesis) and signaling (phosphorylation) with links to lymphocyte proliferation and transcriptional regulation, suggesting proteins in this cluster coordinate nutrient metabolism with immune cell growth and gene expression.","confidence":"Medium","size":18,"edges":113,"triangles":359,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006541","count":6},{"id":"GO:0032869","count":5},{"id":"GO:0042866","count":4},{"id":"GO:0006015","count":4},{"id":"GO:0016310","count":4}]},{"hash":"55705011096545855","title":"Cholinergic neural signaling and behavior","description":"This cluster is dominated by GO terms for cholinergic synaptic transmission, ERK signaling modulation, and nervous system development, with associated behaviors such as locomotion, eating, and learning. The mix of neural signaling, plasticity-related terms, and behavioral descriptors supports a theme of neuronal communication and behavior regulation, though the presence of inflammatory terms suggests additional neural-immune connections. ","confidence":"Medium","size":18,"edges":25,"triangles":3,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007271","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0071380","count":2}]},{"hash":"44513496498116278","title":"Motor neuron differentiation and axon guidance","description":"Based on the dominant GO terms, this cluster centers on motor neuron development, including axon guidance, spinal cord patterning (ventral/dorsal identity, column-specific differentiation), and related neuronal differentiation events. While a few terms reference other tissues, the strong representation of motor neuron\u2013related terms suggests a core theme of motor neuron development and axon pathfinding.","confidence":"High","size":18,"edges":26,"triangles":19,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008045","count":6},{"id":"GO:0097477","count":6},{"id":"GO:0070527","count":6},{"id":"GO:0021937","count":5},{"id":"GO:0072283","count":5}]},{"hash":"2155758880108409698","title":"Immune signaling: B cell activation and antiviral defense","description":"This cluster is dominated by GO terms linked to B cell receptor signaling, affinity maturation, type I interferon signaling, NK cell\u2013mediated cytotoxicity, and cellular defense, pointing to a module centered on adaptive B cell responses with innate antiviral activity. A few terms related to cartilage development and unfolded protein response are present but less representative of the overall pattern.","confidence":"High","size":18,"edges":133,"triangles":621,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071226","count":16},{"id":"GO:0050853","count":11},{"id":"GO:0002344","count":11},{"id":"GO:0060337","count":11},{"id":"GO:0001502","count":11}]},{"hash":"1309645837157149543","title":"Neuronal development and synaptic signaling","description":"The cluster is dominated by GO terms related to nervous system development, brain development, and regulation of synaptic vesicle exocytosis, along with Rac-mediated signaling and axon extension, which together point to neural development and synaptic function as the core theme. A few immune-related terms appear but are likely peripheral noise to the primary neuronal function. ","confidence":"High","size":18,"edges":97,"triangles":223,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:2000300","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0010796","count":4},{"id":"GO:0031384","count":4}]},{"hash":"2050778558373131209","title":"Developmental signaling and vesicle trafficking","description":"The top GO terms point to broad organ development across kidney, liver, and nervous system (including hippocampus) and regulation of axon growth, suggesting a developmental role. In parallel, vesicle trafficking processes (ER-Golgi transport, Golgi-ER retrograde transport, endocytosis) and Hedgehog pathway signaling (Smoothened) indicate involvement in intracellular transport and signaling during development. Together these imply a theme of developmental signaling coordinated with the secretory/endocytic system.","confidence":"Medium","size":18,"edges":44,"triangles":26,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0007224","count":3},{"id":"GO:0006897","count":3},{"id":"GO:0006890","count":3}]},{"hash":"232955055681787199","title":"Dopaminergic Neuron Development and Stress Response","description":"Top GO terms center on dopamine neuron biology (substantia nigra development, dopamine metabolic process) and stress/exposure responses (corticosterone, xenobiotics, ethanol, LPS, cold), with apoptosis and metabolism links (heme biosynthetic process). This suggests a cohesive theme around dopaminergic neuron development and how these neurons respond to hormonal, chemical, and immune-like stress, including pathways related to survival and cell death.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0045964","count":2},{"id":"GO:0051412","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0045471","count":2}]},{"hash":"1410564397578708999","title":"Developmental transcription and signaling regulators","description":"The top GO terms point to DNA-templated transcription coupled with broad developmental processes (face, vagina, placenta, cartilage growth) and signaling pathways (retinoic acid response, p38 MAPK cascade), as well as differentiation programs (fat cell). This combination suggests a regulatory module coordinating vertebrate development and cell fate through transcriptional control and signaling, hence the label.","confidence":"Medium","size":18,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":11},{"id":"GO:0060068","count":8},{"id":"GO:0071300","count":8},{"id":"GO:0038066","count":8},{"id":"GO:0045444","count":8}]},{"hash":"186965489126193173","title":"Innate antiviral NF-kB signaling and ubiquitin-mediated degradation","description":"The GO terms point to innate immune response and defense against viruses, with strong emphasis on NF-kappaB regulation (I-kappaB phosphorylation, non-canonical NF-kB signaling) and ubiquitin/proteasome\u2013related protein turnover (ubiquitin-dependent degradation and ERAD), suggesting a cohesive cluster of proteins involved in antiviral signaling coupled to regulated degradation and apoptosis control.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0051607","count":6},{"id":"GO:0042787","count":6},{"id":"GO:0030433","count":4},{"id":"GO:0051092","count":4}]},{"hash":"985701520170010589","title":"ECM remodeling and angiogenesis","description":"The cluster is headed by proteolysis and extracellular matrix disassembly, with several collagen catabolic and ECM remodeling terms, and includes positive regulation of angiogenesis and endothelial barrier formation, plus plasminogen activation. Immune-related terms (complement activation, response to yeast, neutrophil killing) and amelogenesis point to secreted matrix and tissue remodeling roles. Overall, these proteins seem to function together in ECM remodeling and vascular/process regulation, with ancillary immune involvement.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:0030574","count":3},{"id":"GO:0045766","count":3},{"id":"GO:1903142","count":3},{"id":"GO:0006958","count":3}]},{"hash":"906995331469839287","title":"GPCR-mediated signaling in cardiovascular and immune cells","description":"The top GO terms cluster around GPCR signaling and downstream pathways (positive regulation of GPCR signaling, serotonin receptor signaling), with links to cardiovascular regulation (heart contraction modulation by epinephrine/norepinephrine, vascular smooth muscle contraction) and neuroimmune processes (dopamine secretion regulation, dendritic cell chemotaxis). This suggests a coherent module where GPCR signaling coordinates cardiovascular responses and immune cell behavior. Heat generation may reflect metabolic activation tied to signaling. Confidence: High.","confidence":"","size":18,"edges":144,"triangles":687,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":18},{"id":"GO:0031649","count":18},{"id":"GO:2000420","count":18},{"id":"GO:0001997","count":18},{"id":"GO:0045745","count":18}]},{"hash":"1158625769857630452","title":"Rho GTPase\u2013driven cytoskeletal remodeling and cell motility","description":"This cluster is dominated by GO terms related to GTPase activity regulation, actin cytoskeleton dynamics (filopodium assembly, polarity, cell shape), and processes linked to movement and division (cell migration, mitotic cycle, endocytosis). The inclusion of vesicle trafficking (ER to Golgi) also ties membrane dynamics to cytoskeletal remodeling. Taken together, the proteins likely function in remodeling the cytoskeleton to drive cell movement, shape changes, and associated trafficking.","confidence":"High","size":18,"edges":13,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0031532","count":6},{"id":"GO:0006348","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0006897","count":6}]},{"hash":"1520031355600488868","title":"Immune Cell Signaling and Actin Remodeling","description":"This cluster combines strong signals of actin cytoskeleton organization and lamellipodium assembly with multiple immune-related terms (innate immune response, IL-4 production, B cell affinity maturation) and PI3K/AKT signaling, suggesting proteins that coordinate cytoskeletal remodeling during immune cell activation and signaling. The peripheral nervous system myelination term is less central but may reflect shared signaling pathways or pleiotropy. Overall, the theme is immune signaling linked to actin dynamics.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030036","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0008285","count":3},{"id":"GO:0022011","count":3},{"id":"GO:0002344","count":3}]},{"hash":"1519447400921019412","title":"Endocytic Trafficking and Rab Signaling","description":"This cluster is dominated by endosome-related processes: plasma membrane to endosome transport, protein localization to endosome, and Rab-regulated signaling and Fc receptor signaling, all pointing to endocytic trafficking and its regulation. Phagocytosis reinforces the immune-uptake theme. A few terms (apoptotic process, subtelomeric heterochromatin formation, keratinocyte differentiation, transcription) are less directly linked, but do not override the core endocytic/signaling pattern.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0006909","count":3},{"id":"GO:0048227","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0030216","count":2}]},{"hash":"123955720131436063","title":"Neural-immune signaling and gut epithelium maintenance","description":"The GO terms show neural functions like nerve impulse transmission and paranodal junctions, along with immune responses (B cell activation, IL-4 production, cytokines) and GI epithelial maintenance, suggesting a shared theme of neuro-immune-gut communication rather than a single function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000649","count":8},{"id":"GO:0019226","count":6},{"id":"GO:0030913","count":6},{"id":"GO:0050910","count":6},{"id":"GO:0030277","count":6}]},{"hash":"188711294024302769","title":"Adaptive Immune Activation and Mucosal Immunity","description":"This cluster centers on adaptive immune functions, including T and B cell activation, cytokine production (notably IL-4), and regulation of NK cells, along with immunoglobulin transcytosis in epithelial (mucosal) contexts and defense against bacteria. The combination suggests a coherent theme of immune signaling and mucosal antibody transport rather than unrelated processes.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042102","count":3},{"id":"GO:0030277","count":2},{"id":"GO:0050871","count":2},{"id":"GO:0045404","count":2},{"id":"GO:0042742","count":2}]},{"hash":"1473440199508603463","title":"GPCR Trafficking and Cardiac Signaling","description":"This cluster is enriched for GPCR internalization and clathrin-mediated endocytosis, with concurrent cardiac-related terms (cardiac muscle contraction, heart development) and links to Rho signaling and lamellipodium assembly, suggesting a set of proteins involved in GPCR trafficking that modulates cardiac signaling and cytoskeletal remodeling.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0002031","count":5},{"id":"GO:0072583","count":5},{"id":"GO:0060048","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0035023","count":5}]},{"hash":"307366724101857674","title":"DNA maintenance and nucleotide metabolism","description":"This cluster centers on DNA-related activities (DNA repair and DNA-templated transcription) and on nucleotide metabolism, including nucleotide phosphorylation and biosynthesis of NAD+ and CoA. Together these terms suggest a group of proteins involved in genome maintenance linked to nucleotide-energy metabolism, with dephosphorylation fitting into nucleotide processing. The viral process term is less specific to the cluster\u2019s core function. Overall, the dominant theme is DNA processing coupled with nucleotide/metabolic pathways.","confidence":"Medium","size":18,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0016311","count":5},{"id":"GO:0006281","count":5},{"id":"GO:0016032","count":5},{"id":"GO:0009435","count":2},{"id":"GO:0046939","count":2}]},{"hash":"2032356569407891669","title":"Ribosome biogenesis and translation","description":"The top GO terms are dominated by ribosome-related processes: cytoplasmic translation, translation, ribosome biogenesis, and export of ribosomal subunits from the nucleus, indicating a core theme of protein synthesis machinery. Additional terms for cell cycle and cell division suggest coordination with growth, which commonly accompanies active ribosome biogenesis and translation. A few stress-related terms are present but secondary to the primary ribosome/translation signature.","confidence":"High","size":18,"edges":9,"triangles":0,"max_degree":4,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0002181","count":5},{"id":"GO:0007049","count":5},{"id":"GO:0006412","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0042274","count":4}]},{"hash":"1883258168499045362","title":"PDGF- and calcium-driven cell signaling and migration","description":"These terms point to signaling pathways driven by PDGF and calcium that regulate cell signaling and migration, including neutrophil chemotaxis, STAT phosphorylation, and branching morphogenesis.","confidence":"High","size":18,"edges":150,"triangles":771,"max_degree":17,"top_function":"wound healing","top_go_terms":[{"id":"GO:0014911","count":18},{"id":"GO:0036120","count":18},{"id":"GO:0071300","count":18},{"id":"GO:0007267","count":18},{"id":"GO:0043552","count":18}]},{"hash":"1523761380622413783","title":"GPCR-Driven Neurohumoral Cardiovascular Signaling","description":"The terms are dominated by GPCR signaling and regulation, with strong links to cardiovascular control (positive regulation of heart contraction by catecholamines, vascular smooth muscle contraction, GPCR signaling pathways) and neural/immune signaling (serotonin/dopamine pathways, dendritic cell chemotaxis), suggesting a cluster centered on GPCR-mediated communication across heart, vessels, and neural-immune contexts.","confidence":"High","size":18,"edges":56,"triangles":26,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":8},{"id":"GO:0031649","count":8},{"id":"GO:2000420","count":8},{"id":"GO:0001997","count":8},{"id":"GO:0045745","count":8}]},{"hash":"342919528484892099","title":"Adrenergic GPCR Signaling in Cardiovascular Regulation","description":"This cluster is driven by GO terms tied to GPCR signaling and cardiovascular control, including positive regulation of GPCR signaling, adenylate cyclase-activating GPCR pathways, epinephrine/norepinephrine\u2013driven heart contraction, and vascular smooth muscle contraction, as well as blood pressure regulation. While some energy metabolism terms appear, the strongest signals reflect adrenergic GPCR pathways coordinating heart function and vascular tone.","confidence":"High","size":18,"edges":8,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":17},{"id":"GO:0045777","count":17},{"id":"GO:0022900","count":17},{"id":"GO:0010579","count":17},{"id":"GO:0033861","count":16}]},{"hash":"1768946132265447705","title":"Sympathetic Thermogenesis and Cardiovascular Signaling","description":"This cluster centers on thermogenic and temperature-response processes (diet-induced thermogenesis, heat generation, cellular response to temperature) and cardiovascular signaling (GPCR pathways, vascular smooth muscle contraction, heart contraction regulation by catecholamines), suggesting a coordinated role in sympathetic regulation of metabolism and heart/vessel function. Some terms (e.g., sensory perception of pain, photoreceptor maintenance) appear as outliers, but the dominant theme ties to temperature-related metabolic and cardiovascular signaling.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":11},{"id":"GO:0019233","count":11},{"id":"GO:0045494","count":11},{"id":"GO:0071502","count":11},{"id":"GO:0033861","count":10}]},{"hash":"425443963476013835","title":"GPCR Signaling in Cardiovascular System","description":"This cluster is dominated by GO terms related to GPCR pathways (positive regulation of GPCR signaling, adenylate cyclase-inhibiting serotonin receptor signaling) and processes tied to heart/vascular function (regulation of heart contraction by adrenaline/norepinephrine, vascular smooth muscle contraction). The presence of GTPase activity regulation and immune/neural contexts (dendritic cell chemotaxis, dopamine secretion) aligns with GPCR-mediated signaling across systems, suggesting a unifying theme of GPCR-driven signaling impacting cardiovascular physiology and related processes.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":18},{"id":"GO:0031649","count":18},{"id":"GO:2000420","count":18},{"id":"GO:0001997","count":18},{"id":"GO:0045745","count":18}]},{"hash":"283255485902783706","title":"GPCR-GTPase signaling in inflammation and heart function","description":"This cluster is dominated by GO terms for positive regulation of GTPase activity and GPCR signaling, with additional terms for inflammatory response and regulation of heart contraction by catecholamines. Together they point to a GPCR- and GTPase-mediated signaling module that links immune/inflammatory processes with cardiovascular regulation; some terms (retina development, heat generation) may reflect broader roles or annotation noise.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":10},{"id":"GO:0045745","count":9},{"id":"GO:0006954","count":9},{"id":"GO:0042391","count":9},{"id":"GO:0008283","count":9}]},{"hash":"1510391185271875695","title":"Junctional complexes and surface signaling","description":"The top GO terms cluster around formation of cell junctions (paranodal and septate junctions) and cell surface receptor\u2013mediated signaling, with supporting hints of membrane trafficking to lysosomes and receptor-mediated interactions with pathogens. This suggests a theme of proteins coordinating membrane junctions and signaling rather than a single enzymatic process.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030913","count":5},{"id":"GO:0050910","count":4},{"id":"GO:2000145","count":3},{"id":"GO:0007166","count":3},{"id":"GO:0061462","count":3}]},{"hash":"1874755411147799000","title":"Immune effector regulation and antigen presentation","description":"The terms cluster around regulation of cytotoxic immune responses (NK and T cell degranulation), antibody-dependent cellular cytotoxicity, mast cell degranulation, hypersensitivity pathways, and antigen processing/presentation via MHC I, all pointing to an integrated immune effector and antigen-presenting function. This coherent theme justifies a concise label linking cytotoxic regulation with antigen presentation.","confidence":"High","size":18,"edges":106,"triangles":399,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002859","count":15},{"id":"GO:0043318","count":15},{"id":"GO:0001788","count":14},{"id":"GO:0001798","count":14},{"id":"GO:0042523","count":14}]},{"hash":"494405233561031043","title":"GPCR Signaling in Cardiovascular and Neural Regulation","description":"The top GO terms are dominated by GPCR signaling and its regulation, including positive regulation of GPCR signaling, serotonin receptor signaling, and signaling pathways that inhibit adenylate cyclase. Coupled with terms about heart contraction regulation and vascular smooth muscle activity, the cluster points to GPCR-driven signaling that modulates cardiovascular function and neural processes. Some immune-related term (dendritic cell chemotaxis) suggests broader involvement, but the core theme remains GPCR-mediated signaling in cardiovascular/neuronal contexts.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":18},{"id":"GO:0031649","count":18},{"id":"GO:2000420","count":18},{"id":"GO:0001997","count":18},{"id":"GO:0045745","count":18}]},{"hash":"2032002237048232610","title":"Detox and Aromatic Compound Catabolism","description":"This cluster centers on metabolic detoxification and breakdown of aromatic substrates, highlighted by the beta-ketoadipate pathway and 1,2-dichloroethane catabolic process. Additional catabolic terms (uracil and triglyceride catabolism) and cellular oxidant detoxification support a core theme of metabolic processing and detoxification. Some biosynthetic terms (biotin and antibiotic biosynthesis) are present but seem less central to the main function, suggesting a broader metabolic capability with emphasis on detox and aromatic compound degradation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0098869","count":6},{"id":"GO:0019260","count":5},{"id":"GO:0009102","count":5},{"id":"GO:0009086","count":5},{"id":"GO:0042952","count":5}]},{"hash":"1953309066475419861","title":"DNA damage repair and apoptosis","description":"This cluster's proteins show strong enrichment for DNA metabolism and cell death pathways, including base-excision repair, DNA recombination, DNA catabolic process, and apoptotic process, indicating a focus on genome maintenance and response to DNA damage. A few additional terms (lipid signaling and glycogen regulation) appear but do not define the core theme.","confidence":"High","size":18,"edges":6,"triangles":0,"max_degree":3,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":9},{"id":"GO:0007568","count":9},{"id":"GO:0006310","count":7},{"id":"GO:0006915","count":5},{"id":"GO:0014912","count":5}]},{"hash":"559458937351375118","title":"Terpenoid and cholesterol biosynthesis","description":"This cluster is dominated by GO terms for terpenoid biosynthesis (monoterpene, farnesyl diphosphate, geranyl and geranylgeranyl diphosphate biosynthetic) along with cholesterol biosynthesis, indicating a shared isoprenoid/steroid biosynthetic function. Other terms like protein transport and cell-cycle related processes are present but do not define the main theme. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901663","count":2},{"id":"GO:0015031","count":2},{"id":"GO:0045337","count":2},{"id":"GO:0051290","count":2},{"id":"GO:0043693","count":2}]},{"hash":"2290096960639424944","title":"Innate antiviral signaling and NF-kB regulation","description":"The top GO terms indicate antiviral and innate immune responses, with strong emphasis on NF-kB pathway regulation (I-kappaB phosphorylation, non-canonical NF-kappaB signaling) and ubiquitin-dependent proteolysis (ERAD). This suggests a cohesive function in antiviral innate immunity modulated by ubiquitin-proteasome mechanisms, with broader immune context reflected by spleen development and T-helper cell differentiation signals. Overall, the cluster appears to represent proteins involved in antiviral innate immunity and its regulation by ubiquitin pathways.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051607","count":12},{"id":"GO:0045087","count":12},{"id":"GO:0042787","count":12},{"id":"GO:0033280","count":10},{"id":"GO:0000185","count":9}]},{"hash":"1333044931156166522","title":"GPCR Signaling Modulators in Cardio-Neural-Immune Contexts","description":"The GO terms converge on GPCR signaling regulation (including positive GPCR signaling and serotonin receptor pathways) with links to cardiovascular effects (heart contraction, vascular smooth muscle contraction), neural signaling (dopamine secretion), and immune cell behavior (dendritic cell chemotaxis, eosinophil regulation). This suggests a cohesive theme of GPCR-mediated modulation across cardio-neural-immune contexts, despite the proteins being in an edge-less cluster.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":17},{"id":"GO:0031649","count":17},{"id":"GO:2000420","count":17},{"id":"GO:0001997","count":17},{"id":"GO:0045745","count":17}]},{"hash":"1038201753341952949","title":"Ubiquitin-Dependent Protein Degradation","description":"Contains multiple GO terms tied to ubiquitin tagging and proteasomal degradation, including K48- and K6-linked ubiquitination, autoubiquitination, histone ubiquitination, and ERAD. Also shows links to regulation of NF-kB signaling and TNF pathways, suggesting the cluster reflects components of the ubiquitin\u2013proteasome system engaged in protein quality control and inflammatory signaling.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0070936","count":15},{"id":"GO:0036205","count":15},{"id":"GO:0051865","count":15},{"id":"GO:0085020","count":15}]},{"hash":"1293126540609100414","title":"Epigenetic Regulation of Transcription","description":"The terms cluster around chromatin modification (H3K4, H3K27, H3K36 methylation) and DNA-templated transcription elongation, pointing to regulation of gene expression via histone marks and transcriptional control. While there are also hints of spindle assembly and Rho signaling, the core theme appears to be chromatin-based transcription regulation, with some association to cell division processes.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0006354","count":2},{"id":"GO:1903699","count":2},{"id":"GO:0044648","count":2},{"id":"GO:1903709","count":2}]},{"hash":"1598873273442596187","title":"Skeletal and enamel development","description":"The top GO terms point to bone formation (ossification, skeletal system development, bone maturation) and enamel formation (amelogenesis), with supporting cell\u2013cell adhesion and integrin signaling that facilitate extracellular matrix interactions in skeletal and dental tissues; together this suggests a module focused on skeletal and enamel development.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0046718","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0007157","count":4},{"id":"GO:0097186","count":4},{"id":"GO:0038095","count":3}]},{"hash":"2014310279887163836","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning endosomal transport, PI3K signaling regulation, RNA processing/splicing, chromatin-related processes, and developmental terms across different organisms, with no clear common function tying the proteins together. This variability suggests no coherent, testable cluster function can be assigned.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008333","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0051897","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0006279","count":1}]},{"hash":"683849863897470270","title":"Neural development and myelination","description":"Top terms indicate a strong emphasis on nervous system development and function, with notable terms for myelination, axonogenesis, and sensory perception of sound. Other terms like transcytosis, collagen biosynthesis, and signaling regulation appear less central to the cluster's core theme, so the neural development focus is the most representative label. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":3},{"id":"GO:0045056","count":2},{"id":"GO:0007605","count":2},{"id":"GO:1902043","count":2},{"id":"GO:0032967","count":2}]},{"hash":"900353275289918277","title":"ERAD/Ubiquitin-Proteasome Proteostasis","description":"The most represented terms relate to ubiquitin-dependent ERAD, deubiquitination, and proteasomal protein turnover, plus ER stress regulation and related signaling; this points to a cluster centered on protein quality control and degradation (proteostasis). A few terms like GnRH neuron development or insecticide response seem peripheral.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":9},{"id":"GO:0016579","count":9},{"id":"GO:0002109","count":8},{"id":"GO:1902236","count":8},{"id":"GO:1903265","count":8}]},{"hash":"400000934386506358","title":"Multi-tissue organogenesis and transcription regulation","description":"The top GO terms cluster around development across diverse tissues (retina, heart, bone, pancreas, habenula) and morphogenesis, plus transcriptional control via RNA polymerase II. This suggests a general theme of organ development governed by transcriptional regulation across multiple tissues, rather than a single specific pathway.","confidence":"Medium","size":17,"edges":132,"triangles":622,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":8},{"id":"GO:0002087","count":7},{"id":"GO:0002076","count":7},{"id":"GO:0006366","count":6},{"id":"GO:0000122","count":6}]},{"hash":"1197097859431868116","title":"Cardiac and skeletal muscle and cartilage development","description":"These GO terms cluster around developmental processes governing muscle and cartilage formation, including skeletal muscle differentiation, airway cartilage development (trachea/bronchus), and heart-field/cardiac development, with DNA-templated transcription suggesting regulatory factors driving these programs; calcium signaling and hormone response may modulate differentiation and tissue remodeling.","confidence":"Medium","size":17,"edges":100,"triangles":289,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":13},{"id":"GO:0061145","count":10},{"id":"GO:0060534","count":10},{"id":"GO:0071864","count":10},{"id":"GO:0060532","count":10}]},{"hash":"1977110446652807645","title":"Embryonic organ morphogenesis","description":"The terms point to morphogenesis and development of multiple organs during embryogenesis (hindlimb, eye, heart, placenta, pituitary, gonads, prostate, etc.). The cluster seems to group proteins involved in broad developmental processes rather than a specific molecular function.","confidence":"High","size":17,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035116","count":11},{"id":"GO:0021986","count":11},{"id":"GO:0048048","count":11},{"id":"GO:0003148","count":11},{"id":"GO:0008584","count":11}]},{"hash":"1049198701714097339","title":"Developmental cell division and neuronal migration","description":"This cluster is dominated by terms for cell division, cytokinesis, and microtubule dynamics, alongside multicellular development and neuron migration, suggesting proteins involved in growth, division, and neural positioning during development. There are additional signals related to transcription/translation regulation and a few signaling modalities, but the core theme aligns with developmental cell-cycle processes and neural development.","confidence":"High","size":17,"edges":39,"triangles":84,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":9},{"id":"GO:0007275","count":9},{"id":"GO:0006351","count":9},{"id":"GO:2000767","count":8},{"id":"GO:0007020","count":8}]},{"hash":"1196761595769346480","title":"Membrane Transporters and Signaling Proteins","description":"Top GO terms point to membrane transport (potassium, xenobiotic, galactose) and signaling roles (insulin and growth hormone pathways, small GTPases), plus vesicular neurotransmitter loading. This mix suggests a cluster of membrane-associated transporters and signaling regulators that influence development and immune-related processes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0046626","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1252106052137067951","title":"Actin-driven cytoskeleton remodeling and cell migration","description":"This cluster is dominated by GO terms for actin nucleation, cortical actin assembly, vesicle transport along actin, uropod organization, and T cell polarity, pointing to coordinated actin cytoskeleton dynamics governing cell movement and polarization (with some broader tissue contexts like heart development and glomerular filtration likely incidental).","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001768","count":11},{"id":"GO:0051127","count":11},{"id":"GO:0038089","count":11},{"id":"GO:1903923","count":11},{"id":"GO:0000147","count":11}]},{"hash":"1996622703092564870","title":"ER Stress and Protein Folding","description":"The cluster is dominated by terms tied to endoplasmic reticulum functions, including ER stress response, protein folding in the ER, and related post-translational modification (peptidyl-proline hydroxylation). It also includes oxidative stress and transcriptional regulation terms, suggesting a module where ER quality control intersects with stress-responsive transcriptional regulation.","confidence":"Medium","size":17,"edges":16,"triangles":0,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0043388","count":3},{"id":"GO:1903026","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0006351","count":3}]},{"hash":"2050403599531036156","title":"Mitotic cell cycle and innate immune response","description":"This cluster is rich in cell division and mitotic cycle terms, plus innate immune and interferon-related terms, suggesting proteins that participate in both cell-cycle control and antiviral signaling. Additional terms like atrial septum development and lipid biosynthetic regulation may reflect broader roles or pleiotropy, but the dominant themes are mitosis and innate immunity.","confidence":"Medium","size":17,"edges":21,"triangles":3,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":10},{"id":"GO:0000278","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0051291","count":7},{"id":"GO:0070389","count":6}]},{"hash":"946754130679966125","title":"Calcium and Ion Transport","description":"This cluster is dominated by GO terms for transport of ions and cations across membranes (zinc, monoatomic cations, calcium) and calcium movement within cellular compartments (cytosol to ER; Golgi-associated release). Polyamine transport also fits the ion/solute transport theme. While there are a couple of outlier terms related to lipopolysaccharide biosynthesis and epoxygenase P450 pathways, the common thread appears to be membrane-associated transport and ion homeostasis, justifying a label around calcium and ion transport.","confidence":"Medium","size":17,"edges":7,"triangles":0,"max_degree":3,"top_function":"wound healing","top_go_terms":[{"id":"GO:0009103","count":9},{"id":"GO:0071577","count":9},{"id":"GO:0099132","count":9},{"id":"GO:0019373","count":9},{"id":"GO:1903515","count":9}]},{"hash":"2090842087184338652","title":"Actin cytoskeleton remodeling and protrusion regulation","description":"The cluster is dominated by GO terms for actin-based structures and dynamics\u2014filopodium and podosome assembly, actin filament bundle assembly, and positive regulation of small GTPase activity and signaling\u2014together with regulation of protrusive activities and cell spreading. This cohesive theme points to coordinated actin remodeling governing protrusions like filopodia/podosomes and associated signaling, with one less central term (hepatocyte apoptotic process) likely incidental.","confidence":"High","size":17,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0045956","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0051017","count":3}]},{"hash":"1895586110693092870","title":"Neural development and synaptic signaling","description":"The top GO terms cluster around brain and nervous system development and regulation of synaptic vesicle exocytosis, with signals like ERK cascade regulation and positive gene expression regulation, suggesting a function focused on neural development and synaptic communication (with some noise from unrelated terms).","confidence":"Medium","size":17,"edges":4,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:2000300","count":5},{"id":"GO:0007420","count":5},{"id":"GO:0010796","count":5},{"id":"GO:0031384","count":5},{"id":"GO:0070374","count":5}]},{"hash":"504984540351113541","title":"Unknown","description":"The GO terms span insulin processing, dopaminergic synaptic regulation, ERAD, SREBP signaling, deglutamylation, coagulation, Purkinje cell differentiation, liver regeneration, glucose response, and heat response, indicating involvement in multiple, diverse systems with no single cohesive function. Therefore, a definite label cannot be assigned.","confidence":"","size":17,"edges":22,"triangles":10,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0030070","count":4},{"id":"GO:0032226","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0032933","count":3},{"id":"GO:0035611","count":3}]},{"hash":"547413385380758349","title":"Lipid-Derived Hormone and Terpenoid Metabolism","description":"This cluster centers on biosynthesis and metabolism of lipid-based signaling molecules and terpenoid compounds, including prostaglandins/oxylipins, ent-kaurene/diterpenoids, and retinoic acid/vitamin D pathways. While spanning diverse organisms, the common theme is lipid-derived signaling and hormone-related metabolism, with associated responses. ","confidence":"Medium","size":17,"edges":9,"triangles":2,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001516","count":8},{"id":"GO:0060137","count":7},{"id":"GO:0009822","count":7},{"id":"GO:0031408","count":7},{"id":"GO:0010241","count":7}]},{"hash":"652498579252871351","title":"Nuclear envelope\u2013centrosome\u2013cytoskeleton organization","description":"The top GO terms cluster around nuclear architecture and cytoskeleton interactions: centromere clustering at the nuclear envelope, centrosome localization, nuclear matrix/cytoskeletal anchoring at the nuclear membrane, and nucleokinesis during cell migration. These point to a common theme of how the nucleus interfaces with the cytoskeleton and nuclear envelope to organize cell shape, movement, and division. A few terms related to mechanosensation and extracellular matrix processes appear but are less central to this core theme; overall, the cluster centers on nuclear envelope\u2013cytoskeleton organization.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050966","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0021817","count":2},{"id":"GO:0072766","count":2},{"id":"GO:0051642","count":2}]},{"hash":"1011293297278455964","title":"Cofactor biosynthesis and redox homeostasis","description":"Top GO terms are dominated by biosynthesis of vitamins and cofactors (biotin, protoporphyrinogen IX, thiamine) with an accompanying redox homeostasis term, suggesting these proteins cluster around cofactor production and cellular redox balance. Some developmental or obsolete terms appear as noise, but the strongest signal points to vitamin/cofactor biosynthesis and related redox regulation.","confidence":"Medium","size":17,"edges":5,"triangles":1,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0009102","count":5},{"id":"GO:0006782","count":5},{"id":"GO:0009228","count":4},{"id":"GO:0045454","count":3},{"id":"GO:0042450","count":3}]},{"hash":"2078230929562290677","title":"Hepatic energy metabolism and nutrient response","description":"The cluster is enriched for liver-related metabolic processes (gluconeogenesis, ketone body biosynthesis, and amino acid catabolism) and a general response to starvation/nutrient status, along with liver development. Notch signaling is also present but the dominant theme is hepatic energy metabolism and nutrient handling.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"mitochondrion organization","top_go_terms":[{"id":"GO:0001889","count":6},{"id":"GO:0042594","count":6},{"id":"GO:0019878","count":5},{"id":"GO:0046951","count":5},{"id":"GO:0006094","count":5}]},{"hash":"436252249893526798","title":"Embryonic Development and Morphogenesis","description":"This cluster is dominated by GO terms related to developmental processes across multiple tissues and organs, including craniofacial development (roof of mouth), cartilage morphogenesis, left-right patterning, mesoderm formation, hair follicle morphogenesis, placental and endocrine system development, and endocardial cushion EMT. The unifying theme is broad embryonic development and morphogenesis rather than a single specialized function, indicating these proteins may participate in general organogenesis and tissue patterning.","confidence":"High","size":17,"edges":16,"triangles":0,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":10},{"id":"GO:0003198","count":9},{"id":"GO:0060536","count":9},{"id":"GO:0060972","count":9},{"id":"GO:0003323","count":9}]},{"hash":"1783516712717379003","title":"DNA Repair and Damage Response","description":"Based on the top GO terms, the proteins cluster around multiple DNA repair pathways (base-excision, nucleotide-excision, DNA alkylation repair) and DNA recombination, with several entries indicating anti-apoptotic regulation in the context of DNA damage. Additional terms for xenobiotic, estradiol, and folic acid responses suggest broader stress/metabolic signaling, but genome maintenance remains the dominant theme.","confidence":"High","size":17,"edges":100,"triangles":305,"max_degree":16,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0043066","count":3}]},{"hash":"986334441482195723","title":"GTPase signaling and actin remodeling","description":"The cluster is dominated by GO terms tied to small GTPase pathways (Rho, Ras), their regulation, and actin cytoskeleton dynamics (actin filament bundle assembly, small GTPase-mediated signal transduction, peptidyl-threonine phosphorylation). Endocytosis and cell migration further reflect cytoskeletal remodeling and membrane trafficking driven by GTPases. While heart development and response to food appear, they likely reflect broader developmental and metabolic contexts rather than defining this group's core function.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0051017","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0006897","count":3}]},{"hash":"2095218179458440704","title":"Mitotic cell cycle and developmental signaling","description":"Top terms are centered on mitotic cell cycle and cell division, with spindle orientation and cell-cycle transitions, alongside signaling-related terms (GTPase activity, protein autophosphorylation) and development-associated responses (hypoxia, TGF-beta signaling, brain development). This suggests a theme of proliferation coupled with developmental signaling, especially neural development, hence the label.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0071456","count":2}]},{"hash":"1903797285634827862","title":"T and B cell activation regulation","description":"The proteins in this cluster are enriched for GO terms related to regulating activation of adaptive immune cells, notably negative regulation of activated T cell proliferation and positive regulation of B cell activation. This points to a common theme of lymphocyte signaling and immune response control. Some terms are obsolete or less connected (e.g., signaling notes and unrelated metabolic terms), but the dominant signal is modulation of T and B cell activity via intracellular signaling events such as autophosphorylation. ","confidence":"Medium","size":17,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046007","count":4},{"id":"GO:0035234","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0009089","count":3},{"id":"GO:0019877","count":3}]},{"hash":"198941810285512870","title":"Ribosome Biogenesis and Mitochondrial Translation","description":"Dominant GO signals are translation and ribosome-related: general translation, regulation of translation, LSU-rRNA maturation, and positive regulation of mitochondrial translation. The presence of mitochondrial translation and ribosome maturation terms suggests a cluster of ribosomal/mitochondrial translation components, with some incidental hormone-response signals.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:1902600","count":2},{"id":"GO:0070131","count":2},{"id":"GO:0000470","count":1},{"id":"GO:0006417","count":1}]},{"hash":"1000575444802565471","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by ribosome-related processes: ribosome biogenesis, ribosomal subunit biogenesis, cytoplasmic translation, and export of ribosomal subunits from the nucleus, which together point to assembly and function of the protein synthesis machinery; additional terms touch on cell division and development, but the strongest signal is ribosome production and translation.","confidence":"High","size":17,"edges":29,"triangles":0,"max_degree":13,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0042274","count":3},{"id":"GO:0002181","count":3},{"id":"GO:0000747","count":3}]},{"hash":"476075892470156632","title":"Auditory sensory perception and neural development","description":"The cluster is dominated by GO terms for sound detection and sensory perception of sound, along with nervous system development, innervation, and synapse assembly. Cell adhesion terms further support neural connectivity, pointing to programs of auditory-related sensory processing and neural maturation. While a couple of terms (kidney development, ossification) are less aligned, the prevailing theme centers on auditory sensory functions and neural development.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":7},{"id":"GO:0007605","count":6},{"id":"GO:0001822","count":5},{"id":"GO:0007626","count":5},{"id":"GO:0007399","count":5}]},{"hash":"1482754562688481888","title":"DNA Damage Response and Repair","description":"The cluster's top GO terms center on cellular response to gamma radiation, double-strand break repair (including sister chromatid exchange and homologous recombination regulation), and DNA repair, with supporting involvement in chromatin modification and DNA metabolism. This points to a cohesive theme of DNA damage sensing, signaling, and repair, despite some peripheral terms.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0071480","count":5},{"id":"GO:1990414","count":5},{"id":"GO:0051568","count":4},{"id":"GO:0071320","count":4},{"id":"GO:0010569","count":4}]},{"hash":"572563756085125548","title":"Neural GPCR signaling and sensory/metabolic regulation","description":"The cluster is dominated by GO terms for GPCR signaling leading to adenylate cyclase activation and cGMP signaling, with supporting terms for sensory processes (vision, pain) and cardiovascular/metabolic regulation (blood pressure, thermogenesis, membrane potential). While electron transport chain terms appear, the common theme centers on GPCR-driven signaling that modulates neural sensation and metabolic control.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":13},{"id":"GO:0007190","count":13},{"id":"GO:0045777","count":13},{"id":"GO:0022900","count":13},{"id":"GO:0007601","count":11}]},{"hash":"1756904936912123753","title":"Thermogenesis and Cardiovascular GPCR Signaling","description":"The cluster is dominated by GO terms for thermogenesis, cellular response to temperature, and heat generation, indicating a thermogenic function. It also includes several cardiovascular and GPCR-related terms (positive regulation of GPCR signaling, serotonin receptor signaling that inhibits adenylate cyclase, vascular smooth muscle contraction, and epinephrine/norepinephrine\u2013driven heart contraction), suggesting a cohesive theme where thermogenic responses are linked to GPCR-mediated regulation of cardiovascular function. The presence of pain perception may reflect nociceptive aspects of temperature stress but does not override the dominant thermogenesis/GPCR-cardiovascular pattern.","confidence":"High","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":17},{"id":"GO:0019233","count":17},{"id":"GO:0071502","count":17},{"id":"GO:0033861","count":15},{"id":"GO:0031649","count":15}]},{"hash":"1818085962536194848","title":"Inflammation and Thermoregulation","description":"The top GO terms center on immune and inflammatory responses (immune response, inflammatory response, response to lipopolysaccharide, blood coagulation) alongside temperature- and pain-related processes (cellular response to temperature stimulus, diet-induced thermogenesis, sensory perception of pain). There are also vasomotor and ERK signaling connections that often accompany inflammation. Despite no edges in the cluster, these terms together suggest a coherent theme of inflammatory activity with thermoregulation and pain responses, making this a plausible combined function for the group.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":13},{"id":"GO:0002024","count":12},{"id":"GO:0071502","count":12},{"id":"GO:0045986","count":12},{"id":"GO:0032496","count":12}]},{"hash":"260320584000629261","title":"Cardiovascular GPCR signaling and neuroimmune regulation","description":"The top terms cluster around GPCR signaling regulation and downstream effects (adenylate cyclase inhibition, GPCR pathway activity), with cardiovascular-related processes (heart contraction, vascular smooth muscle contraction) and neurotransmitter involvement (dopamine, serotonin signaling). There are also immune-related terms (dendritic cell chemotaxis), suggesting a broader neuroimmune influence on cardiovascular signaling. This supports a theme of neuroendocrine GPCR-mediated control of heart/vascular function, with some immune modulation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":16},{"id":"GO:0031649","count":16},{"id":"GO:2000420","count":16},{"id":"GO:0001997","count":16},{"id":"GO:0045745","count":16}]},{"hash":"1419719075781585459","title":"Mitochondrial Energy Metabolism and Development","description":"This cluster centers on mitochondrial energy-related processes (ATP synthase assembly, ketone body and ketone catabolism) alongside developmental programs (brain and heart development) and metabolic regulation (insulin secretion response to glucose, starvation response), suggesting a link between mitochondrial energy metabolism and organ development. ","confidence":"Medium","size":17,"edges":132,"triangles":621,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0033615","count":1},{"id":"GO:0042182","count":1},{"id":"GO:0007420","count":1},{"id":"GO:0019552","count":1}]},{"hash":"1568070687056672190","title":"Tight junction regulation and vesicle trafficking","description":"The top GO terms cluster around bicellular tight junction assembly (and its positive regulation), negative regulation of endocytosis, protein transport, and calcium-dependent exocytosis, with supporting hints from Rho signaling and cytokine production. This suggests a cohesive theme of regulating cell\u2013cell junctions and vesicle movement rather than unrelated processes.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045806","count":3},{"id":"GO:0035023","count":2},{"id":"GO:0070830","count":2},{"id":"GO:1903348","count":2},{"id":"GO:0071847","count":2}]},{"hash":"208158703364205458","title":"Glycine Transport and Glycinergic Signaling","description":"The top GO terms point to glycine import across the membrane and glycinergic synaptic transmission, with taurine transport as a related membrane activity, suggesting a core theme of glycine handling and inhibitory signaling in neural contexts. The presence of transcription-related terms (chromatin remodeling, transcription regulation) appears ancillary and may reflect broader nuclear processes among the proteins, rather than a shared mechanism with the transport/signaling terms. Overall, the glycine/taurine transport and glycinergic signaling theme seems primary, with transcription terms as secondary associations.","confidence":"Medium","size":17,"edges":10,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0036233","count":2},{"id":"GO:0043044","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0035435","count":2},{"id":"GO:0032259","count":1}]},{"hash":"545501420477396084","title":"Rho GTPase Signaling and Actin Dynamics","description":"The cluster is dominated by GO terms tied to Rho GTPase signaling and regulation (positive regulation of GTPase activity; regulation of Rho protein signal transduction), actin dynamics (barbed-end capping; phagocytosis), and signaling pathways that influence the cytoskeleton (TGF-beta response; tyrosine phosphorylation). Although there are outliers related to apoptosis and bone development, the strongest and most coherent theme centers on cytoskeletal remodeling controlled by Rho GTPases and associated signaling.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0060348","count":2},{"id":"GO:0051016","count":2},{"id":"GO:0006909","count":2}]},{"hash":"12475266724009398","title":"Mitotic Chromosome Segregation and Cell Division","description":"The cluster\u2019s top GO terms are dominated by mitosis-related processes\u2014sister chromatid cohesion and segregation, spindle assembly, and general cell division\u2014with supporting associations to mitotic DNA replication, indicating a coherent focus on mitotic chromosome dynamics and division. A few terms touch on cytoskeleton and trafficking, but the mitosis signal is strongest.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030433","count":13},{"id":"GO:0000070","count":13},{"id":"GO:0007064","count":13},{"id":"GO:0030042","count":13},{"id":"GO:0090307","count":13}]},{"hash":"706330928245119946","title":"AMPA receptor clustering and synaptic plasticity","description":"This cluster centers on glutamatergic synapse dynamics, with repeated emphasis on AMPA receptor clustering and regulation, plus long-term synaptic plasticity and depression. Additional terms point to neuronal differentiation and axon guidance, reinforcing a neuronal, synapse-focused function. Overall, the dominant theme is AMPA receptor\u2013mediated synaptic regulation and plasticity.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":6},{"id":"GO:0007413","count":5},{"id":"GO:0097113","count":5},{"id":"GO:1900044","count":5},{"id":"GO:2000969","count":5}]},{"hash":"1248005345371257656","title":"Mitochondrial Transport & Membrane Dynamics","description":"This cluster is characterized by GO terms about mitochondrial membrane fission, regulation of membrane potential, and transmembrane transport of various metabolites (citrate, ornithine, manganese, pyridoxal phosphate), indicating a cohesive theme of mitochondrial membrane processes and metabolism. The obsolete terms reflect historical annotations but do not alter the mitochondria-focused interpretation.","confidence":"High","size":17,"edges":17,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0090149","count":6},{"id":"GO:0000002","count":6},{"id":"GO:0051881","count":6},{"id":"GO:0006828","count":5},{"id":"GO:0031921","count":5}]},{"hash":"42984197338349502","title":"Immune-Cardiac Signaling","description":"Based on the GO terms, this cluster includes strong immune-related annotations (innate and adaptive immune responses, B cell receptor signaling) alongside multiple cardiac electrophysiology terms (SA node action potential, regulation of heart rate by cardiac conduction, atrial/ventricular depolarization/repolarization). The combination suggests a theme of immune processes interacting with or regulating cardiac function, i.e., immune-cardiac signaling cross-talk.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045087","count":8},{"id":"GO:0050853","count":7},{"id":"GO:0010765","count":7},{"id":"GO:0001501","count":6},{"id":"GO:0086091","count":6}]},{"hash":"907592797198248683","title":"GPCR-Mediated Cardiovascular and Immune Signaling","description":"The cluster centers on G protein-coupled receptor signaling and its downstream pathways (including regulation of GPCR signaling, GTPase activity, and serotonin receptor signaling), alongside physiological readouts like heart contraction regulation, vascular smooth muscle contraction, and neurotransmitter regulation (dopamine/serotonin). Immune-related terms such as dendritic cell chemotaxis also appear, suggesting a coordinated signaling theme where GPCR pathways drive cardiovascular responses and immune cell communication. This cohesive GPCR-centric pattern supports a representative label for the cluster.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":17},{"id":"GO:0031649","count":17},{"id":"GO:2000420","count":17},{"id":"GO:0001997","count":17},{"id":"GO:0045745","count":17}]},{"hash":"1055696492175937681","title":"Neural Signaling and Sensory Perception","description":"This cluster centers on neural communication and sensory processing, with multiple GO terms for visual perception/learning, dopaminergic synaptic transmission, pain perception, and responses to cocaine, plus related signaling pathways like ERK cascade and prostaglandin signaling. A few outliers like heart development or macrophage chemotaxis exist but do not outweigh the common neural/sensory theme.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":16},{"id":"GO:0008542","count":16},{"id":"GO:0007601","count":16},{"id":"GO:0010759","count":16},{"id":"GO:0048148","count":16}]},{"hash":"1648935151528982658","title":"GPCR-Mediated Cardiovascular and Immune Signaling","description":"GO terms cluster around GPCR signaling and its downstream regulation, including positive regulation of GPCR signaling, serotonin/dopamine signaling, and GTPase activity, plus cardiovascular effects (heart contraction regulation, vascular smooth muscle contraction) and immune processes (dendritic cell chemotaxis, eosinophil trafficking). This points to a cohesive theme of GPCR-mediated signaling coordinating cardiovascular and immune responses.","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":15},{"id":"GO:0031649","count":15},{"id":"GO:2000420","count":15},{"id":"GO:0001997","count":15},{"id":"GO:0045745","count":15}]},{"hash":"941731603139571370","title":"Developmental morphogenesis and ECM remodeling","description":"These terms cluster around organismal development and tissue morphogenesis, including differentiation (trophoblast giant cells, amelogenesis), EMT events, and patterning, with concurrent extracellular matrix remodeling (collagen catabolic process, ECM disassembly). The combination of specific lineage differentiation and ECM dynamics suggests a developmental/morphogenesis program rather than a single pathway.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":6},{"id":"GO:0006351","count":5},{"id":"GO:0097186","count":5},{"id":"GO:0030574","count":5},{"id":"GO:0022617","count":5}]},{"hash":"203979071781922179","title":"Protein modification and turnover with remodeling","description":"The GO terms point to protein regulation via post-translational modification (PARylation, ubiquitination) and degradation (proteolysis), plus ECM remodeling (collagen catabolic process) and mechanotransduction (response to mechanical stimulus). While there are also diverse terms related to immune signaling and differentiation, the strongest common thread is protein modification/degradation coupled with tissue remodeling activities. Confidence: Low","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070212","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0030574","count":3},{"id":"GO:0071260","count":3}]},{"hash":"1131491884057657254","title":"Unknown","description":"The top GO terms span neural signaling and plasticity, hematopoietic development, chromatin dynamics, renal transport, vesicle trafficking, stem cell differentiation, and epithelial junctions, with no single shared function dominating the cluster.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":3},{"id":"GO:0035855","count":2},{"id":"GO:0030220","count":2},{"id":"GO:0006348","count":2},{"id":"GO:0070294","count":2}]},{"hash":"207586183799965182","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms are developmental processes spanning heart development, cartilage formation, left-right patterning, mesoderm and oral roof formation, placenta-related differentiation, pancreatic cells, hair follicle morphogenesis, and endocrine system development. This suggests a cohesive theme of embryogenesis and tissue morphogenesis rather than a specific pathway.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":17},{"id":"GO:0060536","count":17},{"id":"GO:0060972","count":17},{"id":"GO:0003323","count":17},{"id":"GO:0060707","count":17}]},{"hash":"160749332785850489","title":"GPCR Signaling in Cardiovascular and Neuroimmune Pathways","description":"The prominent GO terms center on GPCR signaling and its downstream effects on cardiovascular function (positive regulation of heart contraction by catecholamines, vascular smooth muscle contraction, cAMP-related signaling) as well as neuroimmune processes (dopamine/serotonin signaling, dendritic cell chemotaxis, eosinophil trafficking). This combination suggests a cohesive theme around GPCR-mediated signaling influencing both cardiovascular physiology and neuroimmune communication, rather than a single molecular complex. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":15},{"id":"GO:0031649","count":15},{"id":"GO:2000420","count":15},{"id":"GO:0001997","count":15},{"id":"GO:0045745","count":15}]},{"hash":"48419873409957032","title":"Embryonic development and stem cell maintenance","description":"Most prominent GO terms point to developmental processes (embryonic skeletal development, posterior head segmentation, epithelial migration) and stem cell population maintenance, with additional hints of cell division regulation (mitotic spindle orientation, centrosome localization). While a couple terms are less tightly connected (glucocorticoid catabolism, apoptotic membrane permeability), the overall theme favors development and stem cell maintenance. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000132","count":2},{"id":"GO:0051661","count":2},{"id":"GO:0006713","count":1},{"id":"GO:0045668","count":1},{"id":"GO:0048706","count":1}]},{"hash":"2000394293632872572","title":"Embryonic development and tissue morphogenesis","description":"The GO terms point to diverse morphogenetic processes across multiple tissues (heart, cartilage, palate, hair follicles, etc.) and embryonic patterning, suggesting proteins with broad roles in developmental morphogenesis rather than a single pathway.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":16},{"id":"GO:0060536","count":16},{"id":"GO:0060972","count":16},{"id":"GO:0003323","count":16},{"id":"GO:0060707","count":16}]},{"hash":"408004594128893859","title":"Vertebrate eye and neural development","description":"This cluster shows strong terms for eye morphogenesis and neural development (camera-type eye development, embryonic eye morphogenesis, cerebellum development, peripheral nervous system neuron development, motor neuron axon guidance), plus related embryonic morphogenesis and transcription regulation. The combination suggests proteins involved in vertebrate embryonic development with a particular emphasis on eye and neural lineage formation.","confidence":"High","size":16,"edges":14,"triangles":1,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0006366","count":7},{"id":"GO:0043010","count":6},{"id":"GO:0060441","count":6},{"id":"GO:0048048","count":6}]},{"hash":"590823535428732776","title":"Vertebrate Embryonic and Neural Organogenesis","description":"The proteins are linked to broad vertebrate development, including forebrain and neural tube formation, skeletal and thymus development, and general multicellular organism development, with some MAPK signaling and metal-stress (cadmium) response terms suggesting associated signaling during development. Overall, the cluster centers on embryonic/neural and organogenesis processes.","confidence":"High","size":16,"edges":76,"triangles":172,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071276","count":16},{"id":"GO:0000187","count":14},{"id":"GO:0030900","count":14},{"id":"GO:0001501","count":14},{"id":"GO:0001843","count":14}]},{"hash":"193314318833768665","title":"Flavonoid and lignin biosynthesis","description":"These GO terms cluster around plant secondary metabolism, especially flavonoid/anthocyanin biosynthesis (anthocyanin-containing compounds, cyanidin 3-O-glucoside) and lignin metabolic processes, with supporting hints from related xenobiotic processing; together they point to proteins involved in phenylpropanoid/flavonoid pathways.","confidence":"High","size":16,"edges":27,"triangles":13,"max_degree":10,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":9},{"id":"GO:0052697","count":8},{"id":"GO:0052696","count":8},{"id":"GO:0071412","count":8},{"id":"GO:0030259","count":8}]},{"hash":"2280879751881638408","title":"Sugar Alcohol and Lipid Metabolism","description":"The cluster's top GO terms point to catabolic processing of sugar alcohols (D-sorbitol, xylitol) and ethanol, along with fatty acid omega-oxidation and retinol metabolism, suggesting a shared role in small-molecule energy and lipid-related metabolism; immune response terms appear less central.","confidence":"Medium","size":16,"edges":79,"triangles":182,"max_degree":13,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0032496","count":7},{"id":"GO:0006062","count":5},{"id":"GO:0097327","count":5},{"id":"GO:0051160","count":5}]},{"hash":"368880820591884598","title":"Steroid-regulated immune and fertilization responses","description":"This cluster centers on immune defense and inflammatory processes (inflammatory response, antimicrobial humoral response, defense against bacteria, cytolysis) and reproductive biology (fertilization, sperm-egg fusion). The presence of GO terms for steroid hormone responses (response to 11-deoxycorticosterone, response to dehydroepiandrosterone) suggests a steroid-mediated regulation that ties immune function to reproduction, with retina homeostasis hinting at broader steroid-responsive tissue effects. Overall, a coherent theme is steroid-regulated immunity and fertilization, though one term (retina homeostasis) adds tissue-specific context.","confidence":"Medium","size":16,"edges":26,"triangles":13,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001895","count":4},{"id":"GO:1903496","count":4},{"id":"GO:0006954","count":4},{"id":"GO:0009566","count":4},{"id":"GO:0019730","count":4}]},{"hash":"1633437715722584185","title":"Chondrocyte differentiation and neural development","description":"The top GO terms include strong signals for chondrocyte differentiation, proliferation, and proteoglycan biosynthesis, plus tissue regeneration, which point to cartilage-related development and matrix production. Added neural-related terms (metencephalon development, midbrain-hindbrain boundary development, camera-type eye development, short-term memory) suggest an overarching theme of developmental processes across tissues. Taken together, a label that captures both cartilage-specific differentiation and neural organogenesis best represents the cluster's functional themes.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032332","count":1},{"id":"GO:0042246","count":1},{"id":"GO:1902732","count":1},{"id":"GO:1902730","count":1},{"id":"GO:0002062","count":1}]},{"hash":"529785180748678438","title":"Vision and cardiac calcium signaling","description":"The top GO terms point to visual perception and regulation of opsin-mediated signaling, plus calcium release regulation and cardiac muscle contraction, with supporting signals from GTPase regulation and phosphorylation. This pattern suggests proteins that participate in light-signaling pathways (opsin/GPCR-related) that influence calcium dynamics important for both retinal signaling and cardiac function, justifying a combined label focused on vision and calcium signaling in the heart.","confidence":"Medium","size":16,"edges":21,"triangles":0,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":15},{"id":"GO:0007601","count":15},{"id":"GO:0007507","count":15},{"id":"GO:0043950","count":15},{"id":"GO:0022400","count":14}]},{"hash":"255740792813559727","title":"Developmental morphogenesis and neural signaling","description":"The top GO terms point to tissue morphogenesis across multiple organs (hair follicle, lung, salivary glands) and neural development (substantia nigra, nervous system development), with emphasis on signaling pathways such as Wnt and ERK that regulate proliferation and morphogenesis. This suggests a cluster of proteins involved in developmental processes and associated signaling rather than a single tissue-specific function. ","confidence":"Medium","size":16,"edges":41,"triangles":47,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031069","count":13},{"id":"GO:0007399","count":13},{"id":"GO:0060501","count":13},{"id":"GO:0060661","count":13},{"id":"GO:0031532","count":13}]},{"hash":"1958013392386471267","title":"Mucosal Adaptive Immunity and Lymphocyte Activation","description":"This cluster is dominated by GO terms tied to adaptive immune responses: T cell proliferation and costimulation, B cell activation, cytokine production, and immunoglobulin transport in epithelial cells, along with defense against bacteria and modulation of NK and T cell activity. The pattern suggests a function centered on adaptive immune signaling at mucosal interfaces.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042102","count":15},{"id":"GO:0031295","count":15},{"id":"GO:0030277","count":14},{"id":"GO:0050871","count":14},{"id":"GO:0045404","count":14}]},{"hash":"561059923427517793","title":"Unknown","description":"The terms span cardiac, neural, reproductive, hematopoietic, and general cellular processes with no single overarching function tying them together, making a specific, accurate label difficult to assign.","confidence":"","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0098907","count":4},{"id":"GO:0051764","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0060291","count":4}]},{"hash":"1076631242887496017","title":"Rab-mediated vesicle trafficking","description":"This cluster is dominated by GO terms related to Rab GTPases: Rab protein signal transduction, activation of GTPase activity, and protein transport, along with protein geranylgeranylation and its positive regulation. Geranylgeranylation is essential for Rab membrane targeting, so together these terms point to Rab-dependent vesicle trafficking as the core function of the proteins in this cluster. Some niche terms reflect species-specific biology but do not override the central theme.","confidence":"High","size":16,"edges":105,"triangles":398,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0050771","count":8},{"id":"GO:0032482","count":8},{"id":"GO:0015031","count":8},{"id":"GO:0090630","count":7}]},{"hash":"2279709376719677930","title":"Microglial inflammatory activation","description":"The cluster centers on microglial immune responses: microglial cell activation, inflammatory signaling (including NF-\u03baB and JNK pathways), chemokine production, nitric oxide synthesis, and antigen presentation (MHC II), with responsiveness to bacterial components like lipoteichoic acid, indicating a cohesive microglial inflammatory program.","confidence":"High","size":16,"edges":24,"triangles":3,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001774","count":8},{"id":"GO:0046330","count":8},{"id":"GO:0045080","count":8},{"id":"GO:0071223","count":8},{"id":"GO:0051092","count":7}]},{"hash":"2169042417136264795","title":"Inflammatory Cytokine Signaling Network","description":"The cluster centers on regulation and production of cytokines (IL-6, GM-CSF, interferon) and activation of major signaling pathways (STAT phosphorylation, PI3K/AKT, JNK), with a nod to inflammatory and stress responses (extrinsic apoptosis, xenobiotic response). This combination suggests a cohesive module of immune signaling and inflammatory response.","confidence":"High","size":16,"edges":104,"triangles":370,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0042517","count":6},{"id":"GO:0043491","count":5},{"id":"GO:0048661","count":4},{"id":"GO:0097192","count":4},{"id":"GO:0051897","count":4}]},{"hash":"694010840688570299","title":"Actin dynamics and membrane trafficking","description":"These terms cluster around cytoskeleton remodeling (stress fiber and ruffle assembly) and membrane trafficking (Golgi to plasma membrane transport, endocytic recycling) in response to mechanical cues, with phospholipid homeostasis supporting membrane dynamics. The dominant theme is actin-driven membrane remodeling during mechanotransduction, with some peripheral signals like gene expression regulation and defense. ","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051496","count":4},{"id":"GO:0010628","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0097178","count":4},{"id":"GO:0006893","count":4}]},{"hash":"2060113631067234521","title":"Mitotic spindle and actin dynamics","description":"The cluster's top GO terms cluster around mitosis (mitotic spindle assembly, mitotic cell cycle) and actin filament depolymerization, indicating a core theme of mitotic machinery and cytoskeletal remodeling. Additional signals for autophagy, phagolysosome assembly, and mitochondrial outer membrane permeabilization appear as secondary, suggesting linked cellular stress responses accompanying division.","confidence":"Medium","size":16,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030042","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0001845","count":2},{"id":"GO:0061635","count":1}]},{"hash":"1144811772381292230","title":"Ras- and GTPase-mediated cytoskeleton remodeling and migration","description":"The cluster shows strong enrichment for cytoskeleton and motility terms: cell migration, lamellipodium assembly, and actin cytoskeleton organization, all tied to small GTPase signaling and Ras pathway modulation. While other terms touch development and immune signaling, the shared theme is actin-driven movement and structural remodeling governed by Ras/GTPase activity, making this label representative of the cluster\u2019s core function.","confidence":"High","size":16,"edges":32,"triangles":9,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0016477","count":8},{"id":"GO:0007264","count":8},{"id":"GO:0046580","count":8},{"id":"GO:0002344","count":8},{"id":"GO:0030032","count":8}]},{"hash":"184549216728974041","title":"Hormone signaling and growth regulation","description":"The cluster centers on hormone-related signaling and regulation of growth/repair processes, with top GO terms including prostaglandin biosynthesis and estradiol response, along with MAPK pathway regulation (ERK/JNK) and processes tied to tissue remodeling and progenitor proliferation. This points to a theme of hormone-driven signaling controlling proliferation and regeneration rather than a single enzymatic function. ","confidence":"Medium","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":14},{"id":"GO:0070373","count":13},{"id":"GO:0009734","count":13},{"id":"GO:0043508","count":13},{"id":"GO:0051771","count":13}]},{"hash":"257685127848973445","title":"Ubiquitin-mediated innate immune signaling","description":"The top GO terms cluster around ubiquitin-dependent proteolysis and various forms of ubiquitination (K48-linked, polyubiquitination, autoubiquitination) together with defense and innate immune responses to virus, including NF-kappaB and TNF signaling; this points to a group of proteins that regulate antiviral immune signaling via ubiquitination and downstream pathways (and modulate cell fate via necroptosis and mitochondrial dynamics). Although there are no reported edges, the functional theme is coherent and specific.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0051607","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0070936","count":5},{"id":"GO:0051865","count":5}]},{"hash":"647522190421888040","title":"Neural Sensory Processing and Vision","description":"Top GO terms indicate sensory modalities (pain perception, vision, visual learning) and responses to temperature, alongside signaling processes (protein phosphorylation). This suggests a cohesive cluster centered on neural sensory signaling and visual function, with temperature responsiveness and associated signaling pathways as core features. Some terms reflect broader brain signaling and inflammatory cues, but the dominant theme is neural sensory processing and vision.","confidence":"Medium","size":16,"edges":9,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":14},{"id":"GO:0002024","count":13},{"id":"GO:0071502","count":13},{"id":"GO:0007601","count":13},{"id":"GO:0007596","count":12}]},{"hash":"569822881650590195","title":"Wnt Signaling and Apoptosis Regulation","description":"The strongest signal is positive regulation of canonical Wnt signaling (GO:0090263), suggesting the cluster centers on Wnt pathway regulation. Concurrent apoptotic terms and both pro- and anti-apoptotic neuron regulation imply a role in cell survival decisions, while additional terms (GTPase activity, Hippo signaling, differentiation) point to broader signaling regulatory functions. Overall, the proteins appear to form a signaling-regulation module with emphasis on Wnt signaling and apoptosis.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":9},{"id":"GO:0006915","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0010796","count":6},{"id":"GO:0031384","count":6}]},{"hash":"975766876512303351","title":"Cellular stress and immune response signaling","description":"These proteins are enriched for responses to xenobiotic stimuli, oxidative stress, antiviral defense, and inflammatory cytokines (TNF, IL-1), alongside modulation of signaling via negative regulation of protein kinase activity and apoptotic processes. One term about GI epithelium maintenance is less connected but may reflect barrier-associated stress responses. Overall, the cluster centers on cellular stress and immune signaling with controlled cell fate decisions.","confidence":"Medium","size":16,"edges":12,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":7},{"id":"GO:0070301","count":6},{"id":"GO:0006469","count":6},{"id":"GO:0009615","count":6},{"id":"GO:0071356","count":6}]},{"hash":"1835956364937421458","title":"Unknown","description":"The top GO terms cover diverse areas: immune signaling (neutrophil chemotaxis; IL-18 signaling; B cell homeostasis), development (heart development; blood vessel remodeling), stress responses (response to xenobiotic stimulus; execution phase of apoptosis), sensory/behavioral traits (sensory perception of sound; adult locomotory behavior), and ion transport. The dispersion indicates no clear single functional theme tying all 16 proteins, so Unknown is most appropriate.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030593","count":4},{"id":"GO:0010765","count":3},{"id":"GO:0008344","count":3},{"id":"GO:0060313","count":3},{"id":"GO:0042493","count":3}]},{"hash":"1908246909483153494","title":"Cardiac development and cytoskeletal remodeling","description":"The cluster is dominated by GO terms tied to heart development and cardiac muscle contraction, with strong signals for cytoskeletal dynamics (lamellipodium assembly) and signaling (Rho GTPase regulation and GTPase activity). While there are peripheral terms related to immune signaling and ossification, the recurring themes center on cardiac formation/function and actin-based remodeling, suggesting a module involved in cardiac muscle development and cytoskeletal regulation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0060048","count":5},{"id":"GO:0007205","count":5},{"id":"GO:0030032","count":5}]},{"hash":"1149692913419144025","title":"Neural development and mitosis-related processes","description":"This cluster shows enrichment for neural development terms (spinal cord development; neuron/glial apoptotic processes) and signaling (TGF-beta response; regulation of GTPase activity; peptidyl-tyrosine phosphorylation). It also includes mitosis-related processes (mitotic spindle assembly; sister chromatid segregation) and microtubule-based movement, plus a vesicle trafficking term (retrograde Golgi-to-ER transport). Taken together, the proteins appear to participate in neural development with concurrent involvement in cell division and intracellular transport.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0006890","count":3},{"id":"GO:0034349","count":3},{"id":"GO:0051402","count":3},{"id":"GO:0021510","count":3},{"id":"GO:0043547","count":3}]},{"hash":"249076440212970284","title":"SNARE-driven vesicle trafficking and secretion","description":"Based on GO terms like SNARE complex assembly, exocytic insertion of neurotransmitter receptors, ER-Golgi and intra-Golgi transport, vesicle fusion with the Golgi, and neutrophil/eosinophil degranulation, the cluster centers on SNARE-mediated vesicle formation, targeting, fusion, and secretion, including receptor trafficking and immune granule release.","confidence":"High","size":16,"edges":16,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0035493","count":6},{"id":"GO:0098967","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0099590","count":4},{"id":"GO:0048280","count":3}]},{"hash":"2077920108550434172","title":"Antiviral translation and interferon response","description":"Top GO terms are dominated by translation and its regulation, alongside antiviral/immune signals (response to interferon-alpha, response to virus, negative regulation of viral genome replication, necroptotic process). This pattern points to a group of proteins that connects protein synthesis with antiviral signaling and programmed cell death during viral stress, with notes on selenocysteine incorporation and mRNA decay reflecting translation regulation under stress. Confidence: Medium","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0070266","count":3},{"id":"GO:0045071","count":3},{"id":"GO:0035455","count":3},{"id":"GO:0009615","count":2}]},{"hash":"1000014568182248375","title":"RNA metabolism and antiviral response","description":"This cluster centers on RNA-related processes (translation, rRNA turnover, miRNA processing) together with antiviral/IFN-associated responses (response to interferon-alpha, negative regulation of viral genome replication). While there are a few development-related terms, the strongest shared theme is RNA metabolism linked to innate antiviral signaling, suggesting a module combining RNA processing with immune defense.","confidence":"Medium","size":16,"edges":45,"triangles":31,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0045071","count":3},{"id":"GO:0035455","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0046677","count":3}]},{"hash":"1035648281548444504","title":"Nucleolar RNA processing and chromatin remodeling","description":"The top GO terms cluster around snoRNP assembly and snoRNA localization, plus chromatin remodeling and histone modification regulation, which together point to a nuclear/nucleolar program of RNA processing and chromatin control. Some terms touch mitochondrial ribosome assembly and metabolism, but these are less central, so the dominant theme likely reflects nucleolar RNA processing linked to chromatin remodeling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000492","count":3},{"id":"GO:0048254","count":2},{"id":"GO:0006338","count":2},{"id":"GO:0031063","count":2},{"id":"GO:0061668","count":2}]},{"hash":"1970669226411836581","title":"Endothelial signaling and vascular remodeling","description":"Dominant terms cluster around endothelial biology: regulation of angiogenesis, endothelial cell survival, and extracellular matrix organization, with supporting references to signaling pathways (ERK, GTPases) and protein regulation (ubiquitination, endocytosis). While there are a few metabolic hints (insulin secretion) and broader signaling themes, the strongest coherence points to endothelial- and vascular remodeling processes. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0070086","count":2}]},{"hash":"226266362907619237","title":"Embryonic development and organ morphogenesis","description":"The GO terms point to broad embryonic development and tissue morphogenesis across multiple organs (heart cushions/EMT, cartilage, palate, placenta, pancreas, hair follicles), suggesting a shared theme of organogenesis rather than a single pathway.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":11},{"id":"GO:0060536","count":11},{"id":"GO:0060972","count":11},{"id":"GO:0003323","count":11},{"id":"GO:0060707","count":11}]},{"hash":"887358036807614784","title":"Mitotic spindle organization and cell cycle control","description":"The cluster\u2019s top GO terms are dominated by mitosis- and cell-cycle-related processes, including G1/S transition of the cell cycle, spindle organization, and positive regulation of mitotic centrosome separation. This suggests proteins in this cluster largely participate in cell division and mitotic regulation. Some terms (chloride transport, Golgi localization, NF-kappaB regulation) are less directly tied to mitosis, which may reflect pleiotropic roles or broader functional annotations, but the core signal points to mitotic control. Confidence: Medium","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":2},{"id":"GO:1902476","count":2},{"id":"GO:0030501","count":2},{"id":"GO:0043124","count":2},{"id":"GO:0000082","count":1}]},{"hash":"1620844592756975293","title":"Endosomal trafficking in neurons and heart","description":"The top GO terms cluster around endosome transport, localization, and organization, pointing to a core endosomal trafficking function. The inclusion of heart development and cardiac muscle contraction alongside myelination and memory suggests the proteins operate in endosomal pathways with neural and cardiac tissue\u2013specific roles, possibly regulated by dephosphorylation and Rho signaling. Overall, the set likely represents endosomal trafficking components influencing neural and cardiac signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022011","count":3},{"id":"GO:0060048","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0036010","count":3},{"id":"GO:0008333","count":3}]},{"hash":"227637255861649194","title":"Wnt-ephrin signaling in neural development","description":"The proteins show enrichment for Wnt signaling and ephrin receptor signaling regulation, CNS development, and cell migration, suggesting a neural development-focused signaling module. Endosomal transport also appears, indicating roles in receptor trafficking that support synaptic regulation and development rather than isolated signaling events.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":3},{"id":"GO:0016055","count":3},{"id":"GO:1901187","count":3},{"id":"GO:1900383","count":3},{"id":"GO:0008333","count":3}]},{"hash":"1792009144917518374","title":"Unknown","description":"The top GO terms cover a mix of bacterial lipid biosynthesis (lipopolysaccharide biosynthetic process), ion homeostasis (manganese, potassium, sodium), muscle regulation (negative regulation and relaxation of skeletal muscle contraction), nerve development (vestibulocochlear nerve formation), hormonal response (testosterone), hydrostatic pressure response, and energy metabolism (ATP biosynthetic process). These processes span vastly different organisms and contexts, with no clear, shared functional theme tying them together within a single protein cluster. Therefore, there isn\u2019t a cohesive label beyond Unknown.","confidence":"","size":16,"edges":11,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":6},{"id":"GO:0030026","count":4},{"id":"GO:0021650","count":4},{"id":"GO:0045988","count":4},{"id":"GO:0090076","count":4}]},{"hash":"390659999498453638","title":"GPCR signaling and sensory-behavioral responses","description":"The set is dominated by GPCR-related terms (adenylate cyclase activation, prostaglandin response) that drive diverse outputs, including visual perception/learning, blood pressure regulation, macrophage chemotaxis, and cocaine-related behavior. This points to a theme of GPCR-mediated signaling coordinating sensory, cardiovascular, immune, and neural responses; the electron transport chain term appears less directly tied and may reflect downstream metabolic effects of signaling. ","confidence":"Medium","size":16,"edges":10,"triangles":0,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":14},{"id":"GO:0045777","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0007190","count":13},{"id":"GO:0071380","count":10}]},{"hash":"1293996665778407702","title":"Immune and cardiovascular GPCR signaling","description":"The cluster shows strong representation of GO terms related to immune response and positive regulation of GPCR signaling, plus several cardiovascular-associated terms (heart contraction regulation by epinephrine/norepinephrine, vascular smooth muscle contraction, serotonin receptor signaling via adenylate cyclase). These together point to a functional theme around GPCR-mediated signaling that links immune processes with cardiovascular regulation.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008284","count":16},{"id":"GO:0006955","count":16},{"id":"GO:0033861","count":15},{"id":"GO:0031649","count":15},{"id":"GO:2000420","count":15}]},{"hash":"1918880817822715941","title":"Lipoprotein Metabolism and Cholesterol Efflux","description":"The top GO terms center on cholesterol and phospholipid efflux, lipoprotein metabolic processes, and clearance/assembly of lipoprotein particles (VLDL, chylomicron remnants), with regulation of lipoprotein lipase and endocytosis. This points to a cohesive theme of lipid transport and cholesterol homeostasis across lipoprotein pathways, with a possible minor link to xenobiotic response. ","confidence":"High","size":16,"edges":9,"triangles":3,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0033344","count":3},{"id":"GO:0034382","count":3},{"id":"GO:0033700","count":3},{"id":"GO:0042157","count":3},{"id":"GO:0042493","count":3}]},{"hash":"1539829093621514727","title":"Immune GPCR Signaling and Leukocyte Chemotaxis","description":"The top terms point to antibacterial defense and immune cell migration (defense response to bacterium, dendritic cell chemotaxis, eosinophil regulation) with a strong emphasis on GPCR-mediated signaling and related pathways (GPCR signaling, serotonin receptor signaling, GTPase activity). This suggests a cohesive theme of immune signaling coordinating leukocyte movement, despite a few peripheral terms like heat generation and vascular smooth muscle effects. Confidence in this label is High.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042742","count":16},{"id":"GO:0033861","count":15},{"id":"GO:0031649","count":15},{"id":"GO:2000420","count":15},{"id":"GO:0001997","count":15}]},{"hash":"974264745091201200","title":"Ubiquitin-mediated signaling and adipogenesis","description":"Based on the GO terms, the cluster centers on ubiquitination processes and ubiquitin-dependent proteasomal degradation, combined with regulation of key signaling pathways (NF-kappaB, EGFR, cytokine signaling, NOD-like receptor) and apoptosis, with a notable link to fat cell differentiation. This suggests a cohesive theme of ubiquitin-driven control of signaling and cell fate, including adipogenesis.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":7},{"id":"GO:0043066","count":6},{"id":"GO:0045444","count":5},{"id":"GO:0032088","count":5},{"id":"GO:0071260","count":5}]},{"hash":"897079070524581216","title":"Adherens junctions and synaptic signaling","description":"The top GO terms cluster around receptor clustering, zonula adherens assembly, cell\u2013matrix adhesion, and protein localization to synapse, which together point to junctional complexes and synaptic organization. The inclusion of heart development and neural signaling terms suggests tissue-specific roles for these components, while immune signaling terms reflect broader signaling contexts that intersect with cell adhesion pathways.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043113","count":6},{"id":"GO:0007160","count":5},{"id":"GO:0007507","count":5},{"id":"GO:2000821","count":4},{"id":"GO:0046013","count":4}]},{"hash":"767829054575223267","title":"Neural development and brain maintenance","description":"This cluster's GO terms cluster around nervous system development and brain-related functions, including substantia nigra development, visual learning, and peripheral nervous system myelin maintenance. Some terms touch on neural-vascular interactions (regulation of VEGF production) and neural DNA damage response, suggesting a broader neural context. The beta-ketoadipate pathway term may be non-specific or annotation noise, and the absence of network edges implies the proteins share nervous-system-related annotations rather than forming a tightly connected module.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042952","count":5},{"id":"GO:0008542","count":4},{"id":"GO:0030330","count":4},{"id":"GO:0060973","count":4},{"id":"GO:0021762","count":4}]},{"hash":"768825121103618866","title":"Hormone and xenobiotic metabolism","description":"The cluster\u2019s top GO terms center on metabolism and catabolism of steroids and hormones (bile acids, thyroid hormone, estrogen, ethanol) and xenobiotics, indicating a core theme of processing endogenous and foreign compounds. The inclusion of glycosaminoglycan biosynthesis terms (heparan and chondroitin/dermatan sulfate) suggests additional biosynthetic activity linked to the same metabolic/plasticity context. Overall, the set points to a functional grouping of metabolic and detoxification pathways.","confidence":"Medium","size":16,"edges":41,"triangles":67,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0030573","count":5},{"id":"GO:0042403","count":5},{"id":"GO:0015012","count":5},{"id":"GO:0002002","count":5},{"id":"GO:0030205","count":5}]},{"hash":"675608105536124389","title":"Thermogenic calcium signaling","description":"The cluster is dominated by GO terms for release of sequestered calcium into the cytosol and positive regulation of that release, alongside terms like diet-induced thermogenesis, heat generation, and cellular response to temperature stimulus. This points to a cohesive theme of calcium-dependent signaling that drives thermogenesis and temperature-responsive metabolic processes. Some sensory terms (pain perception, phototransduction) appear, but the core pattern strongly aligns with calcium-mediated thermogenic signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":12},{"id":"GO:0002024","count":12},{"id":"GO:0019233","count":12},{"id":"GO:0051281","count":12},{"id":"GO:0007603","count":12}]},{"hash":"354126298874276736","title":"Ubiquitin-Proteasome Regulation in Neurons Under Stress","description":"Dominant signals are ubiquitin-dependent proteolysis (including SCF-based ubiquitination) with neuronal context, plus links to circadian regulation and stress-induced neuronal apoptotic signaling. This suggests a cluster centered on ubiquitin-mediated protein turnover in neurons under stress.","confidence":"High","size":16,"edges":12,"triangles":1,"max_degree":6,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0060386","count":7},{"id":"GO:0030174","count":7},{"id":"GO:0042752","count":7},{"id":"GO:1902916","count":7}]},{"hash":"1289013335788266527","title":"Ubiquitin-Proteasome System","description":"The top GO terms are dominated by ubiquitination and ubiquitin-dependent degradation processes (protein ubiquitination, polyubiquitination, ubiquitin-dependent ERAD pathway, K48-linked ubiquitination, autoubiquitination), indicating a cluster centered on tagging proteins for proteasomal destruction. Additional terms about regulation of cell cycle, necroptosis, apoptosis, and TLR signaling reflect the broader roles of ubiquitination in signaling and cell fate. Therefore, the label \"Ubiquitin-Proteasome System\" captures both the core degradation function and the regulatory connections.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0016567","count":5},{"id":"GO:0000209","count":5},{"id":"GO:0030433","count":4},{"id":"GO:0070936","count":4}]},{"hash":"1353257316781911225","title":"Axonogenesis and Guidance","description":"The top GO terms are dominated by neural development processes related to axon formation and guidance (axonogenesis, axon extension in guidance, axonal fasciculation). While other terms touch on organ morphogenesis and immune signaling, the strongest signal centers on neurons extending and navigating their axons, making this label representative of the cluster\u2019s core function.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007413","count":7},{"id":"GO:0036303","count":7},{"id":"GO:0072237","count":7},{"id":"GO:0072287","count":7},{"id":"GO:0048846","count":7}]},{"hash":"764764938812514391","title":"ECM Remodeling and Angiogenesis","description":"This cluster centers on extracellular matrix components and remodeling (collagen fibril organization, collagen biosynthesis, proteoglycan catabolic process) and on endothelial morphogenesis and VEGF/HGF signaling regulation (VEGF production, regulation of VEGF and HGF pathways, BMP response), indicating a cohesive theme of ECM remodeling linked to angiogenesis and vascular development.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030199","count":6},{"id":"GO:0071773","count":5},{"id":"GO:2001113","count":5},{"id":"GO:0045636","count":5},{"id":"GO:1902203","count":5}]},{"hash":"793009054966930333","title":"Chemokine signaling and innate immune regulation","description":"This cluster centers on intracellular signal transduction and regulation of chemokine production (e.g., CXCL1, CXCL5), along with NOD1 signaling, which together point to immune signaling and control of chemokine output. Some terms (meiotic recombination, vasopressin secretion) are less aligned, but the dominant theme is signaling pathways involved in chemokine regulation and innate immune responses.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035556","count":7},{"id":"GO:2000340","count":6},{"id":"GO:0010845","count":6},{"id":"GO:0002268","count":6},{"id":"GO:1903759","count":6}]},{"hash":"1870393843296647344","title":"Neural signaling and sensory perception","description":"This cluster is dominated by GO terms related to neural function and sensory processing, including visual perception and learning, dopaminergic synaptic transmission, and behavioral responses to psychoactive stimuli like cocaine, plus signaling pathway regulation (ERK1/2). These connect to neural signaling and sensory pathways. A few terms (heart development, macrophage chemotaxis) are outliers and may reflect broader GO associations in the protein set, but the central theme appears to be neuronal signaling and sensory processing.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":15},{"id":"GO:0008542","count":15},{"id":"GO:0007601","count":15},{"id":"GO:0010759","count":15},{"id":"GO:0048148","count":15}]},{"hash":"1593830725646082755","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoskeleton organization","top_go_terms":[{"id":"GO:0051491","count":3},{"id":"GO:0005975","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0019262","count":3},{"id":"GO:0006046","count":3}]},{"hash":"461359315726861660","title":"GPCR signaling in heart and vasculature","description":"The terms cluster around GPCR pathway regulation and signaling, including serotonin receptor signaling that inhibits adenylate cyclase, modulation of heart contraction by adrenergic signals, and smooth muscle contraction, with additional links to dopamine signaling and dendritic cell chemotaxis, implying a cohesive GPCR-driven network coordinating cardiovascular function and neuroimmune processes.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":15},{"id":"GO:0031649","count":15},{"id":"GO:2000420","count":15},{"id":"GO:0001997","count":15},{"id":"GO:0045745","count":15}]},{"hash":"55877701070606486","title":"Cardiovascular GPCR-cAMP Signaling and Energy Metabolism","description":"This cluster centers on GPCR- and adenylate cyclase\u2013mediated signaling (including prostaglandin E and dopamine receptor pathways) linked to blood pressure regulation and vascular responses, with additional links to Rho signaling and cell proliferation. The presence of electron transport chain and heat generation terms suggests mitochondrial energy metabolism involvement. Overall, the proteins appear to participate in GPCR-driven vascular signaling integrated with energy metabolism and inflammatory modulation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":11},{"id":"GO:0008283","count":11},{"id":"GO:0045777","count":11},{"id":"GO:0022900","count":11},{"id":"GO:0010579","count":11}]},{"hash":"91010407170382848","title":"GPCR signaling and cardiovascular-immune regulation","description":"This cluster centers on GPCR signaling and its downstream pathways (positive regulation of GTPase activity, ERK1/ERK2 cascade) with outputs affecting heart contraction, vascular smooth muscle regulation, and immune cell movement (dendritic cell chemotaxis, eosinophil extravasation). The inclusion of adrenergic regulation of heart force and GPCR pathway regulation suggests a cohesive signaling module driving cardiovascular and immune responses, with sympathetic involvement also tying in heat generation. Confidence: High","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":16},{"id":"GO:0070374","count":16},{"id":"GO:0033861","count":15},{"id":"GO:0031649","count":15},{"id":"GO:2000420","count":15}]},{"hash":"868046855394293771","title":"Ubiquitin-dependent innate antiviral NF-\u03baB signaling","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes and innate antiviral responses, including defense against virus and innate immune activity, along with regulation of NF-\u03baB signaling (I-kappaB phosphorylation and non-canonical NF-\u03baB). Spleen development and T-helper differentiation regulation further support an immune-focused theme. Together, these terms point to ubiquitin-mediated modulation of innate antiviral immunity via NF-\u03baB pathways.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0051607","count":7},{"id":"GO:0045087","count":7},{"id":"GO:1903721","count":5},{"id":"GO:0030433","count":5}]},{"hash":"2139883967729713589","title":"Neuroendocrine GPCR Signaling and Cardiovascular Regulation","description":"The top terms cluster around GPCR signaling and modulation of cardiovascular function (positive regulation of heart contraction by catecholamines, smooth muscle contraction, GPCR signaling pathways, and monoamine-related signaling such as dopamine and serotonin). There are also immune cell chemotaxis terms (dendritic cell chemotaxis) that can be mediated by GPCRs, suggesting a broader neuroendocrine-immune signaling theme centered on GPCR pathways. This combination points to a cohesive label focused on GPCR-driven signaling affecting heart/vascular function and monoaminergic regulation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":16},{"id":"GO:0031649","count":16},{"id":"GO:2000420","count":16},{"id":"GO:0001997","count":16},{"id":"GO:0045745","count":16}]},{"hash":"2277141191956021903","title":"TLR-Mediated innate immune signaling","description":"The top GO terms are dominated by innate immunity and Toll-like receptor signaling (defense response to virus, innate immune response, defense response to Gram-positive bacterium, detection of lipopolysaccharide, MyD88-dependent TLR signaling). This suggests a cohesive set of proteins involved in innate immune activation and pattern recognition, with a few non-immune terms appearing less centrally. Overall, the cluster is best described as innate immune signaling via TLR pathways.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051607","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0002730","count":3},{"id":"GO:0002755","count":3}]},{"hash":"490321059072985618","title":"Developmental transcription and immune differentiation","description":"The top GO terms span transcriptional regulation (RNA polymerase II\u2013mediated, DNA-templated, and miRNA transcription) together with embryonic morphogenesis (eye, lung tubule branching, rhombomere development) and immune cell differentiation (macrophage and myeloid dendritic cell differentiation, IL-4 response, wound healing). This suggests a theme of transcriptional control during development that also drives immune lineage specification, hence the label.","confidence":"High","size":15,"edges":94,"triangles":327,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0048048","count":6},{"id":"GO:0060441","count":5},{"id":"GO:0035470","count":5},{"id":"GO:0030225","count":5}]},{"hash":"1253739649855553640","title":"MAPK signaling regulation with mitosis, autophagy, apoptosis","description":"The terms collectively point to regulatory roles in signaling networks that govern cell growth, division, immune signaling, and stress responses: MAPK/ERK cascade regulation; T cell receptor signaling regulation; mitosis-related processes (kinetochore localization and chromatid biorientation); and autophagy and apoptosis pathways. Because these proteins seem to act as modulators across these connected processes rather than a single pathway, a label like MAPK signaling regulation with mitosis, autophagy, apoptosis captures the core theme.","confidence":"Medium","size":15,"edges":103,"triangles":430,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":15},{"id":"GO:0050860","count":15},{"id":"GO:0000200","count":15},{"id":"GO:0098783","count":12},{"id":"GO:0051895","count":12}]},{"hash":"119992348501256079","title":"Developmental cell migration and signaling","description":"The top GO terms reveal a pattern of cell movement and signaling: neutrophil and NK cell chemotaxis, smooth muscle cell migration, cartilage condensation, responses to PDGF and retinoic acid, and core signaling activities like STAT phosphorylation and PI3K-related processes, plus general cell-cell signaling. Together, these point to proteins involved in signaling-guided cell migration during development and related immune contexts. ","confidence":"Medium","size":15,"edges":30,"triangles":27,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":7},{"id":"GO:2000502","count":6},{"id":"GO:0001502","count":5},{"id":"GO:0014911","count":5},{"id":"GO:0036120","count":5}]},{"hash":"2138511278253327303","title":"Innate Immunity and Organ Morphogenesis","description":"The top GO terms combine innate immune responses (cellular response to fungal origin; complement activation via lectin pathway; NK cell chemotaxis regulation) with diverse morphogenetic processes (cartilage condensation; lymph vessel morphogenesis; mesonephric duct and metanephric kidney development; TGF-beta\u2013driven responses; platelet activation). This suggests a cluster where immune signaling interfaces with tissue development and vascular formation. ","confidence":"Medium","size":15,"edges":59,"triangles":100,"max_degree":13,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":12},{"id":"GO:2000502","count":9},{"id":"GO:0001502","count":8},{"id":"GO:0001867","count":8},{"id":"GO:0071560","count":8}]},{"hash":"777861885554081852","title":"Chromatin Remodeling and Transcription Regulation","description":"This cluster is dominated by GO terms for DNA-templated transcription, chromatin remodeling, and negative regulation of transcription by RNA polymerase II, indicating a group of proteins involved in transcription control and chromatin dynamics. The presence of several tissue-development terms likely reflects broader regulatory roles or context-specific functions, but the core theme centers on transcriptional regulation via chromatin state.","confidence":"High","size":15,"edges":40,"triangles":33,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0043044","count":7},{"id":"GO:0000122","count":6},{"id":"GO:0048752","count":6},{"id":"GO:0060534","count":6}]},{"hash":"746810022519604292","title":"Sulfur amino acid and one-carbon metabolism","description":"The top GO terms cluster around transsulfuration, L-serine catabolic and L-cysteine biosynthetic pathways, hydrogen sulfide biosynthesis, and tetrahydrofolate interconversion, which collectively point to sulfur amino acid handling and one-carbon metabolism. Some lipid-related terms appear but the core signal is sulfur amino acid processing and folate-linked carbon metabolism.","confidence":"High","size":15,"edges":91,"triangles":307,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0006633","count":4},{"id":"GO:0006565","count":4},{"id":"GO:0042572","count":3},{"id":"GO:0006068","count":3}]},{"hash":"1038045314147969288","title":"Developmental gene expression and proteostasis","description":"The cluster centers on regulating gene expression at multiple levels (transcription, translation) and protein turnover (proteasome-mediated degradation), coupled with developmental processes such as multicellular development and cell morphogenesis, and including cell cycle and apoptotic regulation. This suggests a coordinated program of growth and fate determination during development, with broader metabolic terms present but less central to the core theme.","confidence":"Medium","size":15,"edges":68,"triangles":176,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032436","count":6},{"id":"GO:0045727","count":6},{"id":"GO:0007275","count":5},{"id":"GO:0006915","count":4},{"id":"GO:0000902","count":4}]},{"hash":"2146952651438176198","title":"Neuronal actin remodeling and spine morphogenesis","description":"This cluster centers on actin cytoskeleton dynamics: Arp2/3-mediated nucleation, Rac signaling, actin polymerization and barbed-end capping, plus morphogenetic processes like lamellipodium formation and dendritic spine morphogenesis, along with neuron development. These terms together point to coordinated actin remodeling underlying neuronal structure and spine formation, making the name representative. Some non-neuronal terms are present but do not outweigh the core theme of actin-driven neuronal morphogenesis.","confidence":"High","size":15,"edges":33,"triangles":24,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:2000601","count":4},{"id":"GO:0072673","count":4},{"id":"GO:0048666","count":4},{"id":"GO:1990441","count":4},{"id":"GO:0035855","count":3}]},{"hash":"787250199765068127","title":"Spliceosome and RNA processing machinery","description":"The top GO terms are dominated by mRNA splicing via the spliceosome, spliceosomal complex and snRNP assembly, along with other RNA-processing activities (tRNA processing, rRNA maturation, and transcription termination), indicating a cluster centered on RNA processing and splicing machinery. Some terms like hair cycle and ABA response are peripheral noise but do not override the core theme.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":13},{"id":"GO:0000245","count":12},{"id":"GO:0008334","count":10},{"id":"GO:0000387","count":10},{"id":"GO:0006369","count":10}]},{"hash":"1630777886183488568","title":"Mitotic spindle dynamics and chromosome alignment","description":"The top GO terms are dominated by microtubule- and mitosis-related processes: plus-end directed microtubule sliding, lateral kinetochore attachment, spindle midzone assembly, metaphase chromosome alignment, and cytokinesis, all pointing to spindle organization and chromosome segregation during cell division. A couple of outlier terms related to cell junctions or tissue-specific structure exist but do not override the core mitotic signal. ","confidence":"High","size":15,"edges":46,"triangles":57,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0031535","count":12},{"id":"GO:0099607","count":12},{"id":"GO:0030951","count":12},{"id":"GO:0051255","count":12},{"id":"GO:0000911","count":12}]},{"hash":"1736917350568987654","title":"Neural behavior and protein turnover","description":"The top GO terms strongly point to neural/behavioral functions (locomotory exploration behavior, behavioral fear response, psychomotor behavior), suggesting a neural context for this cluster. The presence of ubiquitin-dependent ERAD and proteolysis hints at protein turnover and quality control, which can relate to synaptic remodeling and signaling in neurons. While other terms touch on transcription and ECM remodeling, the strongest signal lies in neural behavior with a component of protein degradation, justifying a label centered on neural behavior and protein turnover. ","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0090084","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0019608","count":1},{"id":"GO:0035641","count":1}]},{"hash":"716037151447798776","title":"Cardiovascular GPCR signaling and immune response","description":"This cluster's top GO terms point to GPCR signaling regulation, serotonin receptor\u2013related signaling that inhibits adenylate cyclase, and pathways controlling heart contraction and vascular smooth muscle, alongside immune response and xenobiotic stimulus response. Together, these terms suggest proteins involved in GPCR-mediated regulation of cardiovascular physiology with an immune/ xenobiotic context. The modest term diversity and lack of edges mean a cohesive theme is plausible but not definitive, yielding a Medium confidence.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0006955","count":2},{"id":"GO:0033861","count":1},{"id":"GO:0031649","count":1}]},{"hash":"1395756351180800037","title":"Transmembrane Transporters","description":"Most enriched terms describe transmembrane transport of diverse substrates (glucose, galactose, sialic acid, fucose, vitamins, nitrate, sodium, xenobiotics) and a vesicular neurotransmitter loading process. The common function seems to be mediating solute movement across membranes, so labeling this cluster as Transmembrane Transporters appropriately captures the shared role, despite substrate diversity.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":4},{"id":"GO:1904659","count":3},{"id":"GO:0098700","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0015757","count":3}]},{"hash":"1022012475193318460","title":"Post-transcriptional mRNA processing and translation regulation","description":"This cluster centers on RNA processing and post-transcriptional regulation: splicing via the spliceosome, translation initiation and reinitiation, mRNA export, polyadenylation and poly(A) tail regulation, mRNA stability in response to stress, and various aspects of mRNA modification. The shared theme is the regulation of the mRNA life cycle after transcription, spanning maturation, export, stability, and translation control.","confidence":"High","size":15,"edges":8,"triangles":0,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":9},{"id":"GO:0045292","count":8},{"id":"GO:0002188","count":8},{"id":"GO:0001731","count":8},{"id":"GO:0010610","count":8}]},{"hash":"850012054601504059","title":"Neural and cardiovascular development signaling","description":"This cluster shows enrichment for developmental terms (heart development, olfactory bulb development, branchiomotor neuron axon guidance) alongside signaling processes (Rho signaling regulation, Kv channel clustering), suggesting a shared theme of developmental signaling influencing neural and cardiovascular systems. Some terms are peripheral (immune signaling, vitamin D metabolism), but the dominant pattern points to developmentally coordinated signaling in neural/vascular contexts.","confidence":"Medium","size":15,"edges":22,"triangles":8,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0032516","count":8},{"id":"GO:0038095","count":7},{"id":"GO:0021772","count":7},{"id":"GO:0035023","count":7},{"id":"GO:0045163","count":6}]},{"hash":"1663679540259776116","title":"Membrane Solute Transporters","description":"The top GO terms point to transmembrane transport of diverse solutes (sodium export, pantothenate, myo-inositol, biotin, glucose) across the plasma membrane, with additional energy-related and metabolic processes (hydrogen peroxide metabolism, carbon monoxide response, mitochondrial electron transport, photosynthesis). This pattern suggests a cluster enriched for membrane transporter proteins or regulators handling multiple substrates across membranes. ","confidence":"High","size":15,"edges":29,"triangles":6,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0071436","count":3},{"id":"GO:0015887","count":3},{"id":"GO:0015798","count":3},{"id":"GO:0015878","count":3},{"id":"GO:0008292","count":3}]},{"hash":"782468572135806931","title":"Dopaminergic signaling and neural plasticity","description":"This cluster centers on neural signaling and behavior: dopaminergic synaptic transmission, cocaine-related behavioral responses, visual perception/learning, and ERK signaling with protein phosphorylation, all pointing to brain signaling and synaptic plasticity. Some terms (like heart development) are less tightly connected, but the dominant theme is neuronal communication and learning-related pathways.","confidence":"Medium","size":15,"edges":104,"triangles":442,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":11},{"id":"GO:0019233","count":11},{"id":"GO:0007507","count":11},{"id":"GO:0007601","count":11},{"id":"GO:0071380","count":11}]},{"hash":"1674266256264929168","title":"Neural Development and Neuroimmune Signaling","description":"This cluster is enriched for neuronal development and connectivity terms (axonogenesis, positive regulation of synapse assembly, corpus callosum development, dopamine response, and pain-related behavior), indicating a focus on neural formation and signaling. At the same time, it shows immune-related responses (lipopolysaccharide signaling, cellular response to LPS, defense against Gram-positive bacteria), suggesting neuroimmune cross-talk or shared signaling pathways between neurons and immune processes. While general processes like DNA replication and mRNA processing are present, the combination of neural development with immune responsiveness best explains the core theme.","confidence":"Medium","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":10},{"id":"GO:0007409","count":10},{"id":"GO:0051965","count":10},{"id":"GO:0031663","count":10},{"id":"GO:0006397","count":10}]},{"hash":"1723998475580457411","title":"Tissue morphogenesis and immune signaling","description":"This cluster mixes developmental morphogenesis terms (mesonephric duct and distal tubule morphogenesis, cartilage condensation, lymph vessel morphogenesis) with immune-related activities (basophil activation, leukocyte tethering/rolling, NK cell chemotaxis regulation, platelet activation, responses to fungal origin, and senescence), suggesting a theme of tissue formation coupled with vascular/immune signaling. The combination points to a broad developmental/organogenesis program that interacts with immune and vascular cues, rather than a single precise pathway.","confidence":"Medium","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":15},{"id":"GO:0010572","count":13},{"id":"GO:0072177","count":13},{"id":"GO:0072287","count":13},{"id":"GO:0036303","count":13}]},{"hash":"1398952176271146014","title":"Developmental signaling and morphogenesis","description":"Proteins in this cluster are enriched for hedgehog signaling (Smoothened), ROBO signaling, axon guidance, nervous system and kidney development, and bone ossification, pointing to a broad developmental signaling theme governing morphogenesis. Immune signaling terms (T cell receptor signaling, mast cell chemotaxis) appear as potential signaling roles, but the dominant pattern is signaling networks that drive development and tissue formation, including ERK cascade regulation as a downstream motif.","confidence":"Medium","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007224","count":7},{"id":"GO:0043931","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0050852","count":6},{"id":"GO:0002551","count":6}]},{"hash":"2105485505954053268","title":"Innate immunity and morphogenesis signaling","description":"The high frequency of GO terms for complement activation (classical/lectin), blood coagulation, and neutrophil-mediated killing (plus response to yeast) points to innate immune activity. Concurrently, hepatocyte growth factor receptor signaling and placental epithelial morphogenesis indicate tissue remodeling and developmental signaling. While transcription-related terms appear, the dominant themes are immune response and morphogenic signaling, justifying this label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006958","count":5},{"id":"GO:0007596","count":4},{"id":"GO:0048012","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0001867","count":4}]},{"hash":"655523586173179828","title":"Inflammation and Coagulation Response","description":"This cluster is dominated by innate immune and coagulation-related GO terms: defense response to fungus, leukocyte migration, neutrophil-mediated killing of gram-positive bacteria, blood coagulation, and regulation of plasminogen activation. While there are a couple of developmental/regulatory terms (pancreas morphogenesis, multicellular organism growth), the strongest signals tie to inflammatory defense and coagulation pathways, suggesting the proteins function together in inflammation-associated host defense and clotting processes.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0061113","count":4},{"id":"GO:0035264","count":4},{"id":"GO:0001878","count":3},{"id":"GO:0070946","count":3}]},{"hash":"1675906362734703446","title":"Inflammation and coagulation","description":"The dominant GO terms point to immune defense (defense response to fungus, neutrophil-mediated killing, leukocyte migration) and hemostasis (blood coagulation, plasminogen activation), suggesting the proteins cluster around inflammatory responses linked to coagulation pathways. Some terms like midbrain development and transcription regulation appear as outliers, but the core signal aligns with inflammation and coagulation processes.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0030901","count":8},{"id":"GO:1903142","count":8},{"id":"GO:0001878","count":6},{"id":"GO:0070946","count":6}]},{"hash":"887520289104289980","title":"GI mucosal immune and xenobiotic stress response","description":"The cluster shows strong signals for innate and inflammatory immune processes, along with xenobiotic/stress responses (ethanol, hypoxia) and GI epithelium maintenance, suggesting a module dedicated to mucosal defense and detoxification in the gut. Negative regulation of transcription by RNA polymerase II may reflect stress-responsive transcriptional control related to these functions.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0042493","count":4},{"id":"GO:0045087","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0006915","count":3}]},{"hash":"2287532653329717994","title":"Macrophage Activation and Lipid Remodeling","description":"The top GO terms point to innate immune functions (antibacterial humoral response, defense against Gram-positive bacteria, IL-1 production) and regulation of immune cells, particularly macrophages. The concurrent lipid-related terms (lipid storage, LDL remodeling, lipid catabolism, phosphatidylcholine remodeling) suggest a macrophage-driven inflammatory state linked with lipid metabolism and remodeling. Overall, the cluster seems to reflect macrophage-mediated immune activation intertwined with lipid processing.","confidence":"Medium","size":15,"edges":29,"triangles":21,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0019731","count":6},{"id":"GO:0042130","count":6},{"id":"GO:0032612","count":6},{"id":"GO:0010884","count":6},{"id":"GO:0045740","count":6}]},{"hash":"2141650243914049800","title":"Meiotic and Mitotic Cell Cycle Regulation","description":"The top GO terms are centered on cell division, including meiotic sister chromatid cohesion, regulation of the meiotic cell cycle, and mitotic cytokinesis, indicating a core theme of cell-cycle control during meiosis and mitosis. Supporting terms about nuclear import of ribosomal and NLS-bearing proteins reflect coordinated transport during division. Some plant-specific terms (amyloplast organization) appear peripheral, but do not outweigh the primary cell-cycle focus.","confidence":"Medium","size":15,"edges":4,"triangles":0,"max_degree":4,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0015991","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0016477","count":7},{"id":"GO:0006607","count":7},{"id":"GO:0051301","count":7}]},{"hash":"706606422037034816","title":"Vesicle trafficking and neuronal signaling","description":"This cluster centers on intracellular transport and membrane dynamics, with GO terms for Golgi to endosome and endosome to melanosome transport, regulation of synaptic vesicle exocytosis, and excitatory postsynaptic potential, plus phospholipid homeostasis and substantia nigra development that align with neuronal function. Some terms (xenobiotic stimulus response, immune response, sporulation, cell division) appear broader or peripheral, suggesting a mix of functions annotated to diverse proteins. Overall, the shared theme is vesicle trafficking and neuronal signaling, justifying this label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035690","count":5},{"id":"GO:0006895","count":3},{"id":"GO:0031321","count":3},{"id":"GO:0035646","count":3},{"id":"GO:2000300","count":3}]},{"hash":"822082321966889230","title":"Brain development and hormone-responsive behavior","description":"This cluster is driven by terms tied to brain development, circadian sleep/wake cycles, and adult locomotory behavior, with notable hormone responses (estradiol) and energy signals (response to carbohydrate). Additional terms on apoptotic processes, phagocytosis, and peptide cross-linking hint at neural remodeling. Taken together, the proteins likely participate in neuronal development and hormone-regulated brain function affecting behavior.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008344","count":3},{"id":"GO:0060548","count":2},{"id":"GO:0042747","count":2},{"id":"GO:0009743","count":2},{"id":"GO:0007420","count":2}]},{"hash":"1031675537103367019","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"The top GO terms are dominated by actin-driven processes such as filopodium and ruffle assembly, adhesion-dependent spreading, and fibroblast migration, plus regulation of GTPase activity and PI3K signaling. These point to cytoskeletal remodeling that enables cell movement and junction formation, with supporting immune signaling (innate immune response, Fc-epsilon receptor pathway) and developmental contexts (heart development, tight junction assembly). Overall, the cluster centers on actin dynamics governing migration, adhesion, and related signaling.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":4},{"id":"GO:0046847","count":4},{"id":"GO:1900026","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0010762","count":3}]},{"hash":"703171167893416472","title":"Cytoskeletal dynamics and signaling","description":"The cluster shows enrichment for cytoskeleton- and signaling-related terms: microspike and spindle assembly, regulation of Rho signaling, thrombin-activated receptor signaling, and pinocytosis, all pointing to actin/microtubule dynamics and associated signaling. While transcription regulation terms appear, they are less cohesive with the main cytoskeletal theme. Overall, the dominant signal is cytoskeletal dynamics and related signaling pathways.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:1903026","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0070493","count":3},{"id":"GO:0030035","count":3}]},{"hash":"117920275511166279","title":"Mitochondrial Metabolite Transport and Fission","description":"GO terms point to mitochondrial transport of diverse metabolites (Mn, PLP, CoA, citrate, ornithine) and mitochondrial membrane fission, with related insulin signaling links. This suggests a cohesive set of mitochondrial transport/dynamics proteins.","confidence":"High","size":15,"edges":18,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:1990314","count":9},{"id":"GO:0006828","count":7},{"id":"GO:0031921","count":7},{"id":"GO:0006843","count":7},{"id":"GO:0090149","count":7}]},{"hash":"1125123954030437003","title":"Developmental gene regulation and chromatin modification","description":"The cluster shows enrichment for DNA-templated transcription and histone demethylation terms, alongside developmental processes like vasculogenesis and myoblast differentiation and Notch signaling regulation, suggesting a core role in regulating gene expression during development and lineage specification.","confidence":"Medium","size":15,"edges":21,"triangles":2,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042264","count":6},{"id":"GO:2001214","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0045746","count":6},{"id":"GO:0042265","count":6}]},{"hash":"1562259029904836503","title":"RNA Pol III transcription and translation regulation","description":"The top GO terms center on RNA polymerase III\u2013mediated transcription (initiation, tRNA transcription, and Pol III\u2013regulated transcription) along with cytoplasmic translation and regulators of translation initiation, indicating a module focused on Pol III-driven gene expression and protein synthesis; other terms like interferon production and insulin signaling appear as broader regulatory connections but do not define the core function.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006384","count":3},{"id":"GO:0002181","count":2},{"id":"GO:1903679","count":2},{"id":"GO:0032728","count":2},{"id":"GO:0042797","count":2}]},{"hash":"445683018095085037","title":"B cell activation and immune signaling","description":"The top GO terms cluster around adaptive immune activation (B cell activation, B cell receptor signaling, immunoglobulin production) and innate/phagocytic processes (complement activation, phagocytosis, innate immune response). The inclusion of T cell costimulation and STAT pathway regulation supports a broader immune signaling module across B and T cells and phagocytic activity.","confidence":"High","size":15,"edges":82,"triangles":244,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050871","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0050853","count":6},{"id":"GO:0006910","count":6},{"id":"GO:0002377","count":6}]},{"hash":"799658303401342338","title":"Developmental signaling and cardiomyocyte regulation","description":"This cluster includes GO terms tied to development (skin and multicellular organism development), cell cycle and signaling regulation (autophosphorylation, GTPase activity, cell shape), and specific cardiac signaling terms (SA node and Purkinje myocyte signaling) along with hypoxia response. The common thread appears to be developmental signaling pathways that influence tissue morphogenesis, including cardiac muscle cell signaling, rather than a single narrowly defined function. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0031954","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0008360","count":2}]},{"hash":"1979958871557214344","title":"Rho GTPase\u2013driven actin remodeling","description":"The top GO terms cluster around regulation of small GTPases, especially Rho, and actin cytoskeleton organization, indicating a core theme of actin dynamics controlled by Rho family signaling. Additional terms touching endocytosis and intracellular transport align with actin-mediated trafficking, while heart development reflects actin\u2019s role in morphogenesis. Overall, the dominant signal points to Rho GTPase\u2013driven actin remodeling rather than a single isolated process.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0030036","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0007507","count":3}]},{"hash":"527218591115997809","title":"Adrenergic GPCR signaling and cardiovascular regulation","description":"Proteins in this cluster show enrichment for cardiovascular-related GO terms (blood coagulation, vascular smooth muscle contraction, heart contraction regulation by epinephrine/norepinephrine) and GPCR signaling (positive regulation of GPCR signaling, serotonin receptor pathways). While there are a few outliers (immune cell chemotaxis, heat generation), the dominant theme is GPCR-mediated control of cardiovascular function and hemostasis, with a possible ancillary link to immune signaling.","confidence":"Medium","size":15,"edges":11,"triangles":2,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":12},{"id":"GO:0033861","count":11},{"id":"GO:0031649","count":11},{"id":"GO:2000420","count":11},{"id":"GO:0001997","count":11}]},{"hash":"61857818441372132","title":"Vision-related GPCR signaling and retinal metabolism","description":"These proteins show strong involvement in visual perception and opsin-mediated signaling, plus GPCR-driven pathways and Rho/GTPase regulation. The electron transport chain annotation points to high-energy metabolism characteristic of photoreceptors, while prostaglandin signaling and macrophage chemotaxis reflect ocular vascular/immune interactions. Together they suggest a vision/retina\u2013linked signaling and metabolic module.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":12},{"id":"GO:0035025","count":12},{"id":"GO:0045777","count":12},{"id":"GO:0022900","count":12},{"id":"GO:0043547","count":11}]},{"hash":"303963931448451739","title":"GPCR signaling across neural, immune, and cardiovascular systems","description":"This cluster is dominated by terms related to GPCR signaling and its modulation, including positive regulation of GPCR signaling, serotonin receptor signaling, dopamine secretion regulation, and adrenergic effects on heart contraction, plus related immune cell chemotaxis. The common theme is GPCR-mediated signaling across neural, immune, and cardiovascular contexts, with various downstream effects such as cAMP/GTPase regulation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":15},{"id":"GO:0031649","count":15},{"id":"GO:2000420","count":15},{"id":"GO:0001997","count":15},{"id":"GO:0045745","count":15}]},{"hash":"1374063131616002999","title":"GPCR Signaling and Neuromodulation","description":"This cluster is dominated by GO terms tied to G protein-coupled receptor signaling and its downstream effects, including GPCR pathway regulation, serotonin receptor signaling that modulates adenylate cyclase, and dopamine secretion regulation. The presence of terms related to heart contraction regulation and vascular smooth muscle contraction suggests cardiovascular, neuromodulatory roles, while dendritic cell chemotaxis points to GPCR-mediated immune cell movement. Together, these indicate a coherent theme around GPCR signaling and its neuromodulatory/cardiovascular/immune outputs.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":15},{"id":"GO:0031649","count":15},{"id":"GO:2000420","count":15},{"id":"GO:0001997","count":15},{"id":"GO:0045745","count":15}]},{"hash":"1422494859679965017","title":"Adrenergic GPCR signaling and heart function","description":"The top GO terms point to activation of adenylate cyclase, GPCR signaling, and epinephrine/norepinephrine\u2013mediated regulation of heart contraction and blood pressure, i.e., adrenergic signaling pathways that raise cAMP and modulate cardiac output. While energy metabolism terms (electron transport chain, heat generation) suggest higher cellular energy demand, the predominant theme is GPCR-cAMP\u2013driven cardiovascular signaling. Saliva secretion appears less central, so the label emphasizes the core cardiac-adrenergic function of the cluster.","confidence":"Medium","size":15,"edges":40,"triangles":16,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":8},{"id":"GO:0007190","count":8},{"id":"GO:0045777","count":8},{"id":"GO:0022900","count":8},{"id":"GO:0010579","count":8}]},{"hash":"2228330623737480429","title":"Neurotransmitter GPCR Signaling and Vascular Regulation","description":"The top GO terms cluster around GPCR signaling and neuromodulation, including serotonin- and dopamine-related signaling, and regulation of adenylate cyclase. They also point to cardiovascular and vascular functions (heart contraction regulation, vascular smooth muscle contraction) and GPCR-mediated processes like dendritic cell chemotaxis. Together, these terms suggest a coherent theme of GPCR-driven neurotransmitter signaling impacting vascular and immune-related processes.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":12},{"id":"GO:0031649","count":12},{"id":"GO:2000420","count":12},{"id":"GO:0001997","count":12},{"id":"GO:0045745","count":12}]},{"hash":"503704854677695975","title":"Vertebrate embryonic development and neural patterning","description":"The top GO terms cluster around embryonic development and neural patterning, including midgut development, forebrain and neural crest cell development, and eye development. Retinoic acid receptor signaling and RA biosynthesis reinforce a patterning role typical of vertebrate embryogenesis. While some metabolic biosynthetic terms appear, the dominant signal ties to embryogenesis and neural patterning, suggesting involvement in early vertebrate organogenesis and neural pattern formation.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0007494","count":15},{"id":"GO:0055129","count":15},{"id":"GO:0031076","count":15},{"id":"GO:0015976","count":15},{"id":"GO:0048384","count":15}]},{"hash":"839382674596316633","title":"Membrane transporters for nutrients and ions","description":"The GO terms point to several transmembrane transport activities (nitrate, glucose, potassium, organic anions, xenobiotics) and related substrate responses (fructose). While a couple of obsolete histone modification terms appear as noise, the dominant signal is transport across cellular membranes of nutrients and ions.","confidence":"High","size":15,"edges":18,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:2000616","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0051573","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0042128","count":2}]},{"hash":"1113388427235992727","title":"GPCR Signaling Regulation","description":"The top GO terms show a clear emphasis on regulation of G protein-coupled receptor signaling, including positive regulation of GPCR signaling, serotonin receptor pathways that modulate adenylate cyclase, and downstream effects like vascular smooth muscle contraction, heart contraction modulation, dopamine secretion, and dendritic cell chemotaxis. This points to a cohesive function theme centered on GPCR-mediated signal transduction and its tissue-specific regulatory outcomes, despite no direct interaction data in the cluster.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":15},{"id":"GO:0031649","count":15},{"id":"GO:2000420","count":15},{"id":"GO:0001997","count":15},{"id":"GO:0045745","count":15}]},{"hash":"619362429530301442","title":"Unknown","description":"The GO terms cover diverse processes (bone, brain, heart development; metabolism; RNA maturation; peroxisome targeting; phagolysosome assembly) with no clear common function or pathway tying the proteins together, so a cohesive, specific label isn\u2019t supported.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0001649","count":5},{"id":"GO:0048265","count":4},{"id":"GO:0010255","count":4},{"id":"GO:0006625","count":4},{"id":"GO:0035246","count":4}]},{"hash":"584533252856780279","title":"Adrenergic GPCR Signaling in Heart and Vessels","description":"The top terms center on GPCR signaling and adrenergic control of cardiovascular function\u2014epinephrine/norepinephrine\u2013driven heart contraction and vascular smooth muscle activity\u2014with supporting links to metabolic regulation (insulin secretion, heat generation) and broader GPCR pathways, indicating a cardiovascular/metabolic signaling theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008284","count":15},{"id":"GO:0050796","count":15},{"id":"GO:0001662","count":15},{"id":"GO:0033861","count":14},{"id":"GO:0031649","count":14}]},{"hash":"677702954386453503","title":"Membrane organization and trafficking","description":"Reasoning: The top GO terms cluster around membrane-related processes: tight junction and endothelial barrier assembly, eisosome and membrane raft polarization, and transcytosis. These point to a shared function in organizing plasma membrane domains and vesicular transport, with additional neural or immune differentiation terms likely representing peripheral aspects rather than core cluster function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":2},{"id":"GO:0050861","count":2},{"id":"GO:0070941","count":2},{"id":"GO:0061028","count":2},{"id":"GO:0045056","count":2}]},{"hash":"1734497139289186723","title":"Ubiquitin-mediated proteolysis in innate antiviral signaling","description":"The terms cluster around ubiquitin-dependent protein degradation (K48, K6 linkages, autoubiquitination), along with defense and innate immune responses to virus and TNF signaling, plus transcriptional regulation. This points to a cohesive role in tagging and degrading substrates to modulate immune signaling and gene expression.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0051865","count":8},{"id":"GO:0070936","count":5},{"id":"GO:0036205","count":5},{"id":"GO:0085020","count":5}]},{"hash":"906547253139664928","title":"Cardiac development and conduction signaling","description":"GO terms point to heart development, SA node electrophysiology, and intercellular cardiac signaling (Notch-regulated cardioblast proliferation, SA node action potentials and communication with atrial muscle), with calcium import driving excitation-contraction. Additional terms reflect tissue remodeling and general locomotion/migration that can accompany heart formation. Overall, the cluster centers on cardiac development and electrical conduction functions.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":9},{"id":"GO:0044707","count":8},{"id":"GO:2000340","count":8},{"id":"GO:0003270","count":8},{"id":"GO:0098907","count":8}]},{"hash":"427124918180650906","title":"Enteric Nervous System Regulation of GI Motility","description":"This cluster is driven by terms tied to enteric nervous system development and peristaltic GI movement, plus smooth muscle contraction features. The presence of positive regulation of GPCR signaling and ERK cascade activity suggests autonomic signaling pathways that drive motility and muscle tone, with some related cardiovascular autonomic regulation terms and xenobiotic response indicating gut-related processing. Overall, the core theme centers on enteric nervous system control of GI motility and associated smooth muscle function.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030432","count":15},{"id":"GO:0048484","count":15},{"id":"GO:0042493","count":15},{"id":"GO:0070374","count":15},{"id":"GO:0033861","count":14}]},{"hash":"846459148627990842","title":"Telomere Maintenance and Chromatin Remodeling","description":"The cluster shows GO terms centered on chromatin remodeling, localization to chromosome telomeres, and regulation of telomere maintenance/repair, suggesting a telomere-chromatin-focused module. A few terms (plant metabolite biosynthesis, prostate development) appear as noise and do not fit the core theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043044","count":3},{"id":"GO:0030850","count":2},{"id":"GO:0051000","count":2},{"id":"GO:0070198","count":2},{"id":"GO:0032208","count":2}]},{"hash":"247512712556869925","title":"Inflammatory GPCR-driven vascular and cardiac signaling","description":"This cluster shows enrichment for inflammatory response and GPCR signaling terms, including positive regulation of GPCR signaling, vascular smooth muscle contraction, and catecholamine-modulated heart contraction, plus dendritic cell chemotaxis and related GTPase activity regulation. The common theme appears to be GPCR-mediated inflammatory control across immune and cardiovascular/vascular cell functions.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":8},{"id":"GO:0043547","count":8},{"id":"GO:0033861","count":6},{"id":"GO:0031649","count":6},{"id":"GO:2000420","count":6}]},{"hash":"783157466817684039","title":"Embryonic development and morphogenesis","description":"Top GO terms point to developmental processes across multiple tissues (EMT in heart, cartilage morphogenesis, left-right patterning, pancreatic endocrine development, placental and palatal development, mesoderm, hair follicle morphogenesis). This suggests a cohesive theme of embryonic tissue formation and organ morphogenesis, justifying the label.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":15},{"id":"GO:0060536","count":15},{"id":"GO:0060972","count":15},{"id":"GO:0003323","count":15},{"id":"GO:0060707","count":15}]},{"hash":"1940527853753378066","title":"Developmental transcription regulators","description":"The top GO terms cluster around transcriptional control (RNA polymerase II\u2013mediated transcription) and diverse embryonic organogenesis processes (pancreas development, digestive tract morphogenesis, ureteric bud branching, neural crest migration, tooth dentinogenesis, habenula and hypothalamus development). This pattern points to proteins involved in regulating gene expression during development across tissues.","confidence":"Medium","size":14,"edges":90,"triangles":352,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0031018","count":8},{"id":"GO:0048557","count":7},{"id":"GO:0090190","count":7},{"id":"GO:0001755","count":7}]},{"hash":"1026531610731307981","title":"Immune signaling and vascular development","description":"These proteins show GO terms tied to immune activation (basophil activation; Fc-gamma receptor signaling; leukocyte tethering/rolling; negative regulation of NK cell chemotaxis) and to development of vascular/lymphatic tissues (lymph vessel morphogenesis; mesonephric duct and metanephric distal tubule morphogenesis), with additional platelet activation and oxidative stress links. The evident overlap suggests a module bridging immune signaling with vascular/lymphatic development rather than a single narrow function. ","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":14},{"id":"GO:0072177","count":14},{"id":"GO:0072287","count":14},{"id":"GO:0036303","count":14},{"id":"GO:0090403","count":14}]},{"hash":"1684876947590174157","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":2},{"id":"GO:0006189","count":2},{"id":"GO:0006006","count":2},{"id":"GO:0097502","count":2},{"id":"GO:0010555","count":2}]},{"hash":"145764131952213730","title":"ER stress\u2013driven transcription and UPR signaling","description":"This cluster centers on RNA Pol II\u2013mediated transcription and ER stress responses, including unfolded protein response and ER-stress\u2013induced apoptosis, with related signals in immune and growth pathways (macrophage differentiation, IL-4 response, IGF signaling, hepatocyte proliferation). The strong connectivity suggests a cohesive module coordinating transcriptional regulation with ER stress and inflammatory/growth cues.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:1990440","count":6},{"id":"GO:0055089","count":6},{"id":"GO:1900103","count":6},{"id":"GO:0001080","count":6}]},{"hash":"1260308735317473487","title":"Histone deacetylation and heterochromatin maintenance","description":"This cluster centers on epigenetic regulation of gene expression: multiple terms point to histone modification (peptidyl-lysine deacetylation), heterochromatin formation/mechanics (rDNA and pericentric heterochromatin), and nucleosome density, all underpinning DNA-templated transcription control. Although a few terms discuss negative regulation of differentiation or signaling, the dominant theme is chromatin state regulation and transcriptional repression via histone deacetylation and heterochromatin dynamics.","confidence":"High","size":14,"edges":77,"triangles":235,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":12},{"id":"GO:0045820","count":11},{"id":"GO:0000183","count":11},{"id":"GO:0034983","count":11},{"id":"GO:0060303","count":11}]},{"hash":"2151294112192639435","title":"Neural and Muscle Development Signaling","description":"The cluster features GO terms centered on nervous system development (neurogenesis, nervous system development, myelination) and muscle formation (positive regulation of myoblast differentiation), with BMP signaling and PI3K/AKT pathway involvement. This points to a coordinated developmental program that links neural and musculoskeletal lineages, while other terms (cranial skeleton morphogenesis, cell proliferation, apoptosis) reflect broader embryonic development.","confidence":"High","size":14,"edges":50,"triangles":71,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0045663","count":6},{"id":"GO:0022008","count":6},{"id":"GO:0048701","count":5},{"id":"GO:0030513","count":5},{"id":"GO:0042552","count":5}]},{"hash":"1526711033964390027","title":"Redox-balanced central metabolism and biosynthesis","description":"Proteins here cluster around core energy and amino-acid metabolism (TCA cycle, 2-oxoglutarate, valine catabolism) with strong redox links (glutathione metabolism, redox homeostasis, oxidant detoxification, NADPH regeneration) and biosynthetic precursor production (porphyrinogen/heme). The combined pattern supports a theme of metabolism tightly coordinated with redox balance and biosynthesis rather than a single pathway. ","confidence":"High","size":14,"edges":48,"triangles":107,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0019878","count":4},{"id":"GO:0006103","count":3},{"id":"GO:0006749","count":3}]},{"hash":"831142129891662865","title":"Genome maintenance and centrosome/cell cycle regulation","description":"This cluster is dominated by GO terms tied to genome integrity and cell division: telomere maintenance via recombination, DNA repair, DNA replication, centrosome cycle, and proteasomal degradation, all of which point to coordinated genome maintenance and cell-cycle progression. Additional terms like protein localization to microtubules support centrosome/spindle dynamics, while innate immune response and antiviral regulation may reflect broader cellular stress responses. The togetherness of replication, repair, and centrosome-associated processes suggests a cohesive theme of genome maintenance and cell-cycle control.","confidence":"High","size":14,"edges":75,"triangles":220,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000722","count":4},{"id":"GO:0051092","count":3},{"id":"GO:0035372","count":3},{"id":"GO:0048701","count":3},{"id":"GO:0006281","count":3}]},{"hash":"772284927197431765","title":"RNA processing and genome maintenance","description":"The cluster centers on RNA metabolism\u2014mRNA splicing and its regulation, mRNA export, and rRNA maturation\u2014while also featuring DNA-related maintenance activities such as transcription-coupled nucleotide-excision repair, SOS response, DNA replication, and recombination. This suggests a coherent theme linking RNA processing with genome integrity support, with a few terms (e.g., viral genome replication) reflecting interactions with replication pathways. ","confidence":"Medium","size":14,"edges":59,"triangles":113,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000398","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0048026","count":6},{"id":"GO:0019079","count":5},{"id":"GO:0006260","count":5}]},{"hash":"1457244108738147245","title":"Cardiovascular and Skeletal Muscle Function","description":"The cluster is enriched for cardiovascular-related terms (blood coagulation, heart development, oxygen transport, nitric oxide biosynthesis) and muscle-related function (slow-twitch skeletal muscle fiber contraction), with oxidative stress responses (response to hydrogen peroxide) and detoxification signals shaping redox biology. A couple of kidney and liver-related terms appear but likely reflect broader systemic context rather than a separate module.","confidence":"Medium","size":14,"edges":50,"triangles":74,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":6},{"id":"GO:0007507","count":6},{"id":"GO:2000490","count":6},{"id":"GO:0031444","count":6},{"id":"GO:0070293","count":6}]},{"hash":"1075308596967371056","title":"Mitochondrial energy metabolism and amino acid biosynthesis","description":"The top GO terms cluster around mitochondrial central metabolism and energy production, including 2-oxoglutarate metabolic process, mitochondrial electron transport (NADH to ubiquinone), and dihydrolipoamide metabolic process, along with amino acid/vitamin biosynthesis (L-glutamate, beta-alanine, thiamine). While a few terms relate to development or obsolete concepts, the dominant signal is mitochondrial metabolism and ATP-generating pathways, suggesting proteins in a shared mitochondrial metabolic module.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0043046","count":14},{"id":"GO:0006103","count":14},{"id":"GO:0042391","count":14},{"id":"GO:0007568","count":14},{"id":"GO:0006120","count":14}]},{"hash":"158874159950619504","title":"Cytoskeletal remodeling and cell polarity signaling","description":"This cluster centers on actin-driven structures (filopodium, podosome), small GTPase signaling, epithelial polarity, and cell spreading, indicating a module focused on cytoskeletal dynamics, adhesion, and polarity establishment that governs cell shape and migration. Some terms related to epigenetic regulation and immune signaling appear, but the core pattern supports cytoskeletal remodeling and cell\u2013environment interactions.","confidence":"Medium","size":14,"edges":22,"triangles":3,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006349","count":6},{"id":"GO:0007264","count":5},{"id":"GO:0090162","count":5},{"id":"GO:0071803","count":5},{"id":"GO:0046847","count":5}]},{"hash":"563719191488055986","title":"Oxidative Stress Detoxification and Toxin Response","description":"Dominant GO terms center on detoxification and stress response, including cellular oxidant detoxification, glutathione metabolism, and response to toxic substances, with supporting signals from toxin catabolic processes and nucleotide-excision repair. While there are hints of metabolic adjustments and calcium-regulated processes, the strongest common thread across the proteins is defense against oxidative/toxic damage and subsequent repair, making this label a concise representation of the cluster.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":14},{"id":"GO:0014810","count":13},{"id":"GO:0009636","count":13},{"id":"GO:0006289","count":13},{"id":"GO:0060316","count":13}]},{"hash":"375484135788876378","title":"Embryonic morphogenesis and immune-vascular signaling","description":"The top GO terms point to tissue morphogenesis (mesonephric duct development, metanephric distal tubule morphogenesis, cartilage condensation, lymph vessel morphogenesis) and immune-vascular activity (platelet activation regulation, leukocyte tethering/rolling, basophil activation, NK cell chemotaxis). This suggests proteins involved in developmental remodeling with coordinated vascular and immune signaling, justifying a label that spans both themes.","confidence":"Medium","size":14,"edges":48,"triangles":60,"max_degree":11,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0010572","count":14},{"id":"GO:0071226","count":14},{"id":"GO:0072177","count":11},{"id":"GO:0072287","count":11},{"id":"GO:0036303","count":11}]},{"hash":"2256298703766117489","title":"Neural Development and Morphogenesis","description":"This cluster is dominated by terms related to neural development and morphogenesis, including forebrain radial glial differentiation, formation of radial glial scaffolds, dendrite development, and branching morphogenesis of a nerve, as well as cochlea morphogenesis. The presence of actin polymerization and synapse plasticity terms supports cytoskeletal dynamics underlying neural wiring. Some outlier terms (bone ossification, T cell signaling, apoptotic cell engulfment) are less connected to this core theme, but do not override the dominant neural development signal.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021861","count":10},{"id":"GO:0021943","count":9},{"id":"GO:0043931","count":8},{"id":"GO:0050852","count":8},{"id":"GO:0043652","count":8}]},{"hash":"1069925968262101469","title":"Growth signaling and metabolic regulation","description":"This cluster centers on growth-related signaling (TGF-beta receptor signaling), cell cycle regulation, telomerase assembly, and metabolic responses (glucose metabolism and ATP response), suggesting a theme of coordinating growth, proliferation, and energy state. Some terms are broad or obsolete, but the core appears to tie growth signaling with metabolism and cell cycle control.","confidence":"Medium","size":14,"edges":14,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0030511","count":3},{"id":"GO:0071318","count":3},{"id":"GO:0071157","count":3},{"id":"GO:0006006","count":2},{"id":"GO:1905323","count":2}]},{"hash":"1815446071606396760","title":"Chromatin-Linked Transcription Regulation","description":"The cluster shows strong enrichment for DNA-templated transcription and regulation of transcription factor activity, along with nucleosome-related terms (nucleosome density/positioning, heterochromatin formation). A few outliers exist (e.g., semicircular canal morphogenesis), but the dominant terms indicate chromatin context shaping transcription, justifying this label.","confidence":"High","size":14,"edges":45,"triangles":53,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:1902894","count":6},{"id":"GO:0060303","count":6},{"id":"GO:0016584","count":5},{"id":"GO:0051091","count":5}]},{"hash":"1386510992563168402","title":"Vesicle trafficking and signaling regulation","description":"This cluster includes GO terms for intracellular protein transport and vesicle fusion with the Golgi, plus multiple entries on regulation (both positive and negative) of major signaling pathways (TOR, PI3K/AKT, ERK) and immune-related processes (inflammatory response, T cell activation) as well as differentiation (stem cell and astrocyte). The common thread appears to be proteins involved in vesicle trafficking that modulate signaling networks and cell fate decisions. ","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":3},{"id":"GO:0048712","count":2},{"id":"GO:0048863","count":2},{"id":"GO:0048280","count":2},{"id":"GO:0032007","count":1}]},{"hash":"1649098972865549640","title":"Diverse small-molecule biosynthesis and catabolism","description":"These proteins appear to participate across multiple metabolic pathways, spanning biosynthesis and degradation of a wide array of small molecules (tetrahydrobiopterin, phylloquinone, mycolic acids, retinoic acid, retinal, tropane alkaloids, propylene, androgens, antibiotics, etc.). The top GO terms collectively point to varied metabolic processes rather than a single pathway, suggesting a broad, metabolically versatile cluster. The network metrics (modest edge count and triangles) support a cohesive but diverse metabolic module rather than a single, focused function.","confidence":"Medium","size":14,"edges":12,"triangles":5,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0006729","count":4},{"id":"GO:0042376","count":4},{"id":"GO:0071768","count":4},{"id":"GO:0006710","count":4}]},{"hash":"1424461477512935633","title":"Unknown","description":"The GO terms span vitamin D response, prostaglandin/oxylipin biosynthesis, endothelial adhesion, maternal parturition, plant diterpene metabolism, and copper response, with no single shared function. The absence of edges or interaction structure provides no cohesive pathway or process to unite these proteins, so a definitive cluster label cannot be determined.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":5},{"id":"GO:0001516","count":5},{"id":"GO:0071603","count":5},{"id":"GO:0060137","count":4},{"id":"GO:0009822","count":4}]},{"hash":"918569015186513382","title":"RNA processing and translation initiation regulation","description":"This cluster is enriched for mRNA processing and splicing-related terms (spliceosome, cis splicing, regulatory ncRNA silencing, polyadenylation) together with translation-related terms (translation reinitiation, preinitiation complex formation, regulation of translational initiation, IRES-dependent viral translation). The inclusion of mRNA export also ties RNA maturation to translation control, including viral contexts, supporting a cohesive theme of RNA processing followed by regulation of translation.","confidence":"High","size":14,"edges":67,"triangles":150,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":10},{"id":"GO:0031047","count":9},{"id":"GO:0048026","count":9},{"id":"GO:0045292","count":9},{"id":"GO:0002188","count":8}]},{"hash":"148043652103774891","title":"Endothelial adhesion and sprouting angiogenesis","description":"The Top Terms cluster around cell adhesion (heterophilic and homophilic) and cell-matrix adhesion, together with positive regulation of cell migration in sprouting angiogenesis and negative regulation of endothelial proliferation in sprouting angiogenesis, pointing to a core role in endothelial adhesion during angiogenic sprouting. Inflammation-related terms (inflammatory response, response to lipopolysaccharide) and response to mechanical stimulus further suggest integration with immune signaling and mechanotransduction in developing vasculature. Overall, this cluster seems to represent adhesion-enabled vascular sprouting with inflammatory context.","confidence":"Medium","size":14,"edges":23,"triangles":2,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007157","count":10},{"id":"GO:0007275","count":9},{"id":"GO:0007160","count":8},{"id":"GO:0090050","count":8},{"id":"GO:0051965","count":8}]},{"hash":"1817554485000876363","title":"GPCR-GTPase Signaling in Sensory and Developmental Processes","description":"Top GO terms indicate GPCR-related signaling (dopamine receptor pathway, prostaglandin response), regulation of small GTPases, and protein phosphorylation, alongside broad developmental/sensory roles (pain perception, visual perception/learning, heart development, macrophage chemotaxis). This suggests a cluster of signaling proteins engaged in GPCR and GTPase pathways with roles in sensory processing and development, rather than a single tissue-specific function. Confidence: Medium","confidence":"","size":14,"edges":45,"triangles":36,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0043547","count":11},{"id":"GO:0007507","count":11},{"id":"GO:0071380","count":11},{"id":"GO:0007191","count":10}]},{"hash":"1576763073908435851","title":"GPCR Signaling in Heart and Neural Regulation","description":"This cluster is dominated by terms tied to GPCR signaling and its downstream effects, including positive regulation of GPCR signaling, serotonin and dopamine pathways, and regulation of heart contraction and vascular smooth muscle activity. The presence of dopamine/serotonin-related signaling and dendritic cell chemotaxis suggests a broader neuroimmune dimension anchored by GPCR pathways, linking cardiovascular control with neural-immune signaling. Confidence: Medium","confidence":"","size":14,"edges":58,"triangles":107,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":11},{"id":"GO:0031649","count":11},{"id":"GO:2000420","count":11},{"id":"GO:0001997","count":11},{"id":"GO:0045745","count":11}]},{"hash":"1599943429138666736","title":"FGF Signaling in Development","description":"FGF signaling appears to drive multiple downstream cascades in this cluster, highlighted by ERK1/ERK2 and PI3K/AKT pathways and a cellular response to FGFR stimulus. The GO terms point to broad developmental roles, including myoblast differentiation, neuron migration, lymph node development, and CD8 T cell proliferation, all consistent with FGF-mediated growth, differentiation, and immune-associated processes. The convergence on FGFR-stimulated signaling across diverse tissues supports labeling this cluster as FGF signaling in development.","confidence":"High","size":14,"edges":11,"triangles":1,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0048661","count":2},{"id":"GO:0070371","count":2},{"id":"GO:0051897","count":2},{"id":"GO:0044344","count":2},{"id":"GO:0001764","count":2}]},{"hash":"756437413232349942","title":"Neural development and cytoskeletal signaling","description":"The top terms center on nervous system development, neuroblast proliferation, and cell differentiation, indicating a neural developmental context. Supporting this, lamellipodium assembly and Rac signaling point to actin cytoskeleton dynamics and cell migration, which are essential for neural crest migration and neurite outgrowth. Negative regulation of cell-matrix adhesion further ties to controlled cell movement, while synaptic vesicle recycling regulation suggests neuronal synaptic processes. Together, these terms suggest a cluster of proteins involved in neural development with coordinated cytoskeletal signaling.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0030032","count":4},{"id":"GO:0001953","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0007275","count":3},{"id":"GO:1903422","count":3}]},{"hash":"1048151150982305245","title":"Golgi-ER vesicle trafficking and SNARE assembly","description":"This cluster centers on vesicle transport between the ER and Golgi, intra-Golgi transport, and Golgi ribbon formation, plus SNARE complex assembly and exocytic receptor insertion at the postsynaptic membrane, all of which together point to coordinated vesicle trafficking through the Golgi apparatus and SNARE-mediated membrane fusion, with neuronal exocytosis components contributing to synaptic potentiation.","confidence":"High","size":14,"edges":55,"triangles":94,"max_degree":13,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048280","count":9},{"id":"GO:0006891","count":9},{"id":"GO:0006888","count":9},{"id":"GO:0090161","count":9},{"id":"GO:0035493","count":8}]},{"hash":"574943333971275542","title":"Embryonic Development and Angiogenesis","description":"The top GO terms point to developmental processes and tissue morphogenesis, especially spinal cord and somite development, endothelial proliferation, and sprouting angiogenesis, with EMT and tight junction assembly supporting tissue organization. While some terms (innate immune response, cholesterol storage) are peripheral, the dominant signal is embryonic development and vascular morphogenesis, suggesting these proteins participate in forming tissues and vasculature during development.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0021510","count":13},{"id":"GO:0001935","count":13},{"id":"GO:0002040","count":13},{"id":"GO:0034381","count":13},{"id":"GO:0001837","count":13}]},{"hash":"1679860725862149930","title":"Endomembrane Trafficking and Endosome Dynamics","description":"This cluster is dominated by GO terms describing vesicle transport within the endomembrane system (ER\u2013Golgi, Golgi\u2013endosome, endosome transport, receptor recycling, and endosome organization) and endosome maturation. A couple of terms about mitochondrial fission and cell division are less related, but the central theme is endomembrane trafficking and endosome dynamics.","confidence":"Medium","size":14,"edges":13,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0035646","count":3},{"id":"GO:0036010","count":3},{"id":"GO:0000266","count":3},{"id":"GO:0045022","count":3}]},{"hash":"672052602367352866","title":"Unknown","description":"The top GO terms cover translation, mRNA processing, metabolism (glycolysis/gluconeogenesis), protein assembly, cell division, and virus\u2013host interaction, with no single unifying function linking them all. This dispersed set makes a coherent, specific label hard to justify.","confidence":"","size":14,"edges":31,"triangles":37,"max_degree":6,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0032781","count":4},{"id":"GO:0002181","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0050689","count":3}]},{"hash":"180748746527720108","title":"Translational control and ribosome dynamics","description":"The top GO terms cluster around cytoplasmic translation and ribosome-related processes: initiation, elongation, termination, fidelity, and even ribosome disassembly, as well as mRNA turnover via deadenylation-dependent decay. Selenocysteine incorporation ties directly to translation, while glial cell proliferation and chromatin-related annotation appear less central. Overall, the shared signal is coordinated regulation of protein synthesis and ribosome function, with ancillary links to RNA decay pathways.","confidence":"High","size":14,"edges":81,"triangles":268,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:2000767","count":8},{"id":"GO:0014009","count":8},{"id":"GO:0001514","count":8},{"id":"GO:0006449","count":8},{"id":"GO:0045901","count":8}]},{"hash":"281627432751925963","title":"mRNA splicing and processing regulation","description":"There is a clear emphasis on mRNA maturation: splicing (including alternative splicing), processing, export, and regulation of stability and translation, suggesting a coordinated mRNA processing module.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":10},{"id":"GO:0000381","count":8},{"id":"GO:0006378","count":8},{"id":"GO:0045292","count":7},{"id":"GO:1901407","count":7}]},{"hash":"2105529907456636853","title":"Neuronal ion-channel signaling and synaptic transmission","description":"The top GO terms cluster around ion transport (sodium/potassium), membrane depolarization, excitatory postsynaptic potentials, and glycinergic synaptic transmission, all core to neuronal excitability and communication. Additional terms like long-term potentiation and detection of mechanical sound support a synaptic signaling theme. A couple of terms related to acrosome reaction and ovulation rhythm may reflect shared signaling pathways rather than a separate function, but the dominant pattern is neuronal signaling.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0051899","count":4},{"id":"GO:0035725","count":4}]},{"hash":"1176375221488712077","title":"GPCR-Neuropeptide Signaling in Blood Pressure Regulation","description":"The terms point to a shared theme of GPCR-driven signaling, including neuropeptide signaling and adenylate cyclase activation, together with regulation of blood pressure and related vascular tone. Additional terms hint at metabolic and immune modulation (electron transport, heat generation, TNF and eosinophil regulation) that can be influenced by GPCR pathways, suggesting a broad signaling hub rather than a single enzyme complex. Given the mix, the label captures the core nervous-system\u2013vascular signaling axis with ancillary metabolic and immune links.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":11},{"id":"GO:0022900","count":11},{"id":"GO:0010579","count":11},{"id":"GO:0007218","count":10},{"id":"GO:0007190","count":10}]},{"hash":"2179899408399567834","title":"Adrenergic Thermogenesis and Vascular GPCR Signaling","description":"This cluster centers on thermogenesis and temperature response (diet-induced thermogenesis, heat generation, cellular response to temperature stimulus) linked with GPCR-mediated signaling and adrenergic regulation that controls heart contraction and vascular smooth muscle activity, suggesting a coherent theme of adrenergic-driven thermogenesis and vascular signaling.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":12},{"id":"GO:0019233","count":12},{"id":"GO:0071502","count":12},{"id":"GO:0033861","count":11},{"id":"GO:0031649","count":11}]},{"hash":"2054750540453328130","title":"Mitochondrial transport and fission","description":"The top GO terms cluster around transport of metabolites across mitochondrial membranes (citrate, ornithine, CoA, pyridoxal phosphate, manganese), combined with mitochondrial membrane fission. This points to proteins involved in mitochondrial metabolite transport and mitochondrial dynamics, with some links to energy signaling pathways such as insulin/IGF responses. Obsolete terms are not informative for the current interpretation.","confidence":"Medium","size":14,"edges":18,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0097274","count":7},{"id":"GO:0006828","count":6},{"id":"GO:0031921","count":6},{"id":"GO:0006843","count":6},{"id":"GO:0090149","count":6}]},{"hash":"993421152652538800","title":"Amino acid and monoamine metabolism","description":"This cluster is dominated by amino acid and monoamine biosynthesis/catabolism signals (dopamine, histamine, taurine, glutamate) and related alkaloid metabolic processes, with the TCA cycle suggesting underlying energy support. While there are a few outliers (e.g., Leydig cell differentiation), the core pattern points to amino acid/amine metabolism and neurotransmitter biosynthesis as the main theme.","confidence":"Medium","size":14,"edges":82,"triangles":265,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":6},{"id":"GO:0033327","count":4},{"id":"GO:0071312","count":4},{"id":"GO:0051454","count":4},{"id":"GO:0042412","count":4}]},{"hash":"1646374586596203079","title":"Growth signaling and proliferation regulators","description":"These proteins are enriched for terms that promote cell proliferation, kinase signaling, and GTPase regulation, including positive regulation of proliferation, autophosphorylation, and serine/threonine kinase activity. Additional signals point to Wnt/calcium signaling, mitotic cell cycle, and multicellular development, suggesting a coordinated role in growth control and developmental signaling. Some terms like mRNA transport and cellular hypoxia response appear peripherally, but the dominant theme is regulatory signaling of growth and proliferation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008284","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0031954","count":4},{"id":"GO:0051028","count":4}]},{"hash":"1801814293539549603","title":"Bacterial lipid biosynthesis and cell envelope","description":"This cluster centers on lipid metabolism and cell envelope biosynthesis in bacteria, with strong representation of fatty acid biosynthesis, long-chain fatty acids, and lipoteichoic acid biosynthesis, plus menaquinone biosynthesis. NRPS activation could reflect secondary metabolite production, which can accompany lipid pathway gene clusters. Some GO terms (seed coat development, plant-associated phenylpropanoid metabolism) are likely annotation noise, but the core theme is bacterial lipid and envelope biosynthesis.","confidence":"Medium","size":14,"edges":65,"triangles":136,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009698","count":8},{"id":"GO:0008218","count":8},{"id":"GO:0043041","count":8},{"id":"GO:0001676","count":8},{"id":"GO:0009234","count":8}]},{"hash":"2285632946536899612","title":"Neurodevelopment and Axon Guidance","description":"This cluster's top GO terms center on neural development, axon guidance, and nerve structure (branchiomotor neuron axon guidance, trigeminal nerve organization, semaphorin-plexin signaling), with related transcriptional regulation and some bone morphogenesis associations via semaphorin signaling. The dominant theme is neural patterning and guidance, so the name reflects the core function of the proteins.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0043931","count":3},{"id":"GO:0021785","count":2},{"id":"GO:0001886","count":2},{"id":"GO:0021637","count":2}]},{"hash":"714495098776437835","title":"Vertebrate embryonic development and organogenesis","description":"The top GO terms cluster around vertebrate development and tissue patterning\u2014EMT in cardiac development, left/right patterning, cartilage morphogenesis, and organogenesis in pancreas, placenta, brain (metencephalon), and eye. These point to broad embryonic development and morphogenesis rather than a single molecular function, justifying a label focused on developmental processes across organs.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0003323","count":3}]},{"hash":"444126555723660283","title":"Ubiquitin-Proteasome Regulation & NF-kB Signaling","description":"Proteins in this cluster are dominated by ubiquitin-dependent proteolysis (including SCF-regulated ubiquitination) and histone ubiquitination, suggesting a core role in targeted degradation and chromatin regulation. The presence of TNF signaling components, NF-kappaB\u2013inducing kinase activity, and I-kappaB phosphorylation ties the cluster to inflammatory signaling pathways. Some circadian and histone catabolic terms appear secondary, but ubiquitin-proteasome and NF-kB-related processes clearly predominate.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0031146","count":4},{"id":"GO:0042752","count":3},{"id":"GO:0036205","count":3},{"id":"GO:0085020","count":3}]},{"hash":"712461552746536429","title":"GTPase signaling and synaptic receptor regulation","description":"This cluster is driven by terms related to positive regulation of GTPase activity and Rho signaling, pointing to modulation of cytoskeletal dynamics and signaling networks. The presence of AMPA receptor clustering indicates synaptic receptor organization, suggesting a neuronal signaling focus. Additional GO terms (sodium transport regulation, Fc receptor signaling, and responses to nitric oxide and endothelin) imply broader, stimulus-responsive signaling regulation across systems. Overall, the common theme is regulation of intracellular signaling pathways, including synaptic receptor modulation, rather than a single narrowly defined process.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0002028","count":2},{"id":"GO:0060368","count":2},{"id":"GO:0001878","count":2}]},{"hash":"714614674133855710","title":"Dopaminergic signaling and locomotor behavior","description":"The cluster is dominated by GO terms tied to dopamine receptor signaling (adenylate cyclase-activating pathway) and locomotion, along with fear-related behavior, indicating a neurobehavioral module where dopaminergic signaling regulates movement and behavioral responses. Prostaglandin response and insulin regulation terms may reflect broader neurometabolic links but do not outweigh the dopamine\u2013movement theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007626","count":8},{"id":"GO:0071380","count":8},{"id":"GO:0008283","count":8},{"id":"GO:0008284","count":8},{"id":"GO:0050796","count":8}]},{"hash":"2130897013644788851","title":"Collagen/ECM Remodeling","description":"These proteins cluster around collagen-related and extracellular matrix remodeling processes (collagen catabolic process, extracellular matrix disassembly, collagen fibril organization) and development-related terms (amelogenesis, trophoblast differentiation) as well as cellular responses to mechanical stimuli. The dominant signal is collagen/ECM remodeling, suggesting a role in ECM dynamics and tissue development, with some auxiliary terms that are less central to this theme. Confidence: High","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030574","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0097186","count":4},{"id":"GO:0022617","count":4},{"id":"GO:0006879","count":3}]},{"hash":"2250819404692505889","title":"Unknown","description":"The top GO terms cover a wide range of functions\u2014from protein homooligomerization and Rho signaling to mitotic chromatid segregation and presynaptic membrane regulation, plus brain-related processes like lipid transport across the blood-brain barrier and FGFR signaling. This mix does not reveal a single cohesive biological theme or pathway, making it hard to assign a specific, representative label beyond Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0000070","count":2},{"id":"GO:1901630","count":2},{"id":"GO:1903002","count":2}]},{"hash":"40886391860371253","title":"Spinal motor neuron development and axon guidance","description":"This cluster is dominated by GO terms describing spinal cord motor neuron differentiation/fate specification, ventral interneuron specification, medial motor column neuron differentiation, and motor neuron axon guidance, suggesting a coordinated program of motor neuron development. There is a single outlier term related to metanephric renal vesicle morphogenesis, but the prevailing signals point to motor neuron specification and pathfinding within the spinal cord, with supporting context from broader neural development terms like Purkinje/horizontal cell signaling. ","confidence":"High","size":13,"edges":9,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021937","count":13},{"id":"GO:0001705","count":13},{"id":"GO:0072283","count":13},{"id":"GO:0035852","count":13},{"id":"GO:0021527","count":13}]},{"hash":"2283447044451271873","title":"Proteostasis and ribosome biogenesis","description":"Predominant terms relate to protein quality control (deubiquitination, ERAD, proteasome regulation) and to ribosome biogenesis/translation (rRNA maturation and translation). A couple of outliers (insecticide response, GnRH neuron development) are less connected.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":11},{"id":"GO:0002109","count":8},{"id":"GO:1902236","count":8},{"id":"GO:0030433","count":8},{"id":"GO:0021888","count":8}]},{"hash":"1373975880322334357","title":"ER Stress and Proteostasis Regulation","description":"The top terms cluster around ER quality control and proteostasis: ER-associated degradation (ERAD), unfolded protein maintenance, proteasome regulation, and calcium signaling linked to the ER, suggesting a cohesive role in managing protein folding and ER stress. Peripheral terms (e.g., certain developmental or insecticide response terms) are less central to this core pattern.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0002109","count":12},{"id":"GO:1902236","count":12},{"id":"GO:1903265","count":12},{"id":"GO:0030433","count":12},{"id":"GO:0021888","count":12}]},{"hash":"1466778612183555524","title":"Brain and Visual System Development","description":"These proteins show enrichment for brain and sensory organ development terms (forebrain, brain, cerebellum, retina development, visual perception) along with ERK1/2 signaling involved in developmental processes, suggesting a cohesive role in neural and visual system formation. Some terms (heart, gonad development) are present but do not outweigh the neural/visual theme.","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0030900","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0007601","count":2}]},{"hash":"397184810952427980","title":"Ion Homeostasis and Muscle Regulation","description":"The top GO terms center on potassium transport and homeostasis (import/export, intracellular) and manganese homeostasis, with supporting terms for skeletal muscle relaxation and ATP production, suggesting a core theme of ion balance supporting muscle function and energy metabolism. Some terms like vestibulocochlear nerve formation and hormone response are less directly connected but do not override the dominant ion/muscle theme.","confidence":"Medium","size":13,"edges":9,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0097623","count":6},{"id":"GO:1990573","count":6},{"id":"GO:0030007","count":6},{"id":"GO:0030026","count":5},{"id":"GO:0021650","count":5}]},{"hash":"1562866215834347986","title":"Blood coagulation and vascular remodeling","description":"Based on the topGO terms, the cluster is enriched for blood coagulation, collagen catabolic process, and positive regulation of angiogenesis, all pointing to vascular remodeling and extracellular matrix turnover. There are also terms related to transcription regulation and development that may reflect broader or overlapping roles, but the strongest signals center on vascular/ECM-associated functions. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0071230","count":3},{"id":"GO:0060048","count":2},{"id":"GO:0050830","count":2}]},{"hash":"471968019346078221","title":"Actin Cytoskeleton Remodeling and Cell Polarity","description":"The cluster centers on actin cytoskeleton dynamics\u2014evident from actin filament polymerization and cortical patch assembly/localization\u2014and cell polarity/shape establishment, with calcium signaling and mitochondrial localization as related modulators. Some brain-related terms appear but are less central to the core cytoskeletal theme.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0051592","count":13},{"id":"GO:0051654","count":13},{"id":"GO:0000281","count":13},{"id":"GO:0000147","count":13},{"id":"GO:0051666","count":13}]},{"hash":"636896054067440021","title":"Developmental Signaling Networks","description":"This cluster is enriched with GO terms spanning neural and organ development (nervous system development, axial mesoderm formation, kidney development, regulation of dendrite development), guidance and morphogenic signaling (smoothened signaling, Roundabout signaling), apoptosis and cell migration, and immune signaling (T cell receptor signaling, IL-27\u2013mediated signaling). The common thread is a network of developmental signaling pathways coordinating tissue patterning, neural development, and cross-talk with immune signaling, making \"Developmental Signaling Networks\" an accurate, concise label.","confidence":"High","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":11},{"id":"GO:0050852","count":11},{"id":"GO:0007224","count":11},{"id":"GO:0035385","count":11},{"id":"GO:0001822","count":11}]},{"hash":"657989557323673968","title":"Unknown","description":"The top GO terms are highly diverse, spanning transcriptional regulation, signaling, multiple developmental processes, and various immune/stress responses. With no single dominant function tying the terms together and no edges connecting proteins, there is no clear cohesive theme for this cluster.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0016055","count":4},{"id":"GO:0032496","count":4},{"id":"GO:0030901","count":4},{"id":"GO:0051216","count":3}]},{"hash":"1193698789332974586","title":"Metabolism and detoxification of plant compounds and xenobiotics","description":"This cluster centers on biosynthesis and modification of secondary metabolites (e.g., anthocyanin/flavonoid pathways) and broad detoxification processes (glucuronidation, xenobiotic metabolism), alongside other metabolic activities (carbohydrate and glycolipid biosynthesis, degradation of xenobiotics). A few terms related to neuron localization or genistein response appear as outliers, but the dominant theme is metabolic processing and metabolite management.","confidence":"Medium","size":13,"edges":33,"triangles":38,"max_degree":9,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":11},{"id":"GO:0052696","count":10},{"id":"GO:0008360","count":10},{"id":"GO:0005975","count":10},{"id":"GO:0002175","count":10}]},{"hash":"1323930133269825184","title":"Membrane receptor signaling and lysosomal trafficking","description":"The top GO terms cluster around cell surface receptor signaling, receptor-mediated virion attachment, and localization to lysosomes/vacuoles, with supporting terms for junction assembly and responses to lipoprotein stimuli. This pattern points to a functional group of membrane-associated signaling proteins involved in endocytic/lysosomal trafficking, rather than a single, narrow process; the visual perception term may be an outlier or cross-term.","confidence":"Medium","size":13,"edges":15,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:2000145","count":2},{"id":"GO:0007166","count":2},{"id":"GO:0061462","count":2},{"id":"GO:0090528","count":2}]},{"hash":"683915985575073182","title":"Neuronal signaling and sensory perception","description":"The cluster is dominated by nervous system\u2013related terms (visual perception and learning, dopaminergic synaptic transmission, pain perception, ERK signaling) indicating a core theme of neural signaling and sensory processing; a few outliers (macrophage chemotaxis, heart development, prostaglandin response) are likely pleiotropic or contextual rather than defining the cluster.","confidence":"High","size":13,"edges":14,"triangles":1,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0071380","count":10},{"id":"GO:0006468","count":10},{"id":"GO:0008542","count":10},{"id":"GO:0007601","count":10}]},{"hash":"35432248654187085","title":"DNA Repair and Apoptosis","description":"The top terms are base-excision repair (11), DNA recombination (11), and DNA catabolic process (8), with apoptotic process also enriched (8). These collectively point to DNA damage response and genome maintenance, often leading to apoptosis; other terms like cellular signaling (cAMP response, PI dephosphorylation) may be secondary or context-specific noise.","confidence":"High","size":13,"edges":12,"triangles":2,"max_degree":6,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":11},{"id":"GO:0006310","count":11},{"id":"GO:0006915","count":8},{"id":"GO:0014912","count":8},{"id":"GO:0006308","count":8}]},{"hash":"1673627124374718156","title":"Immune and neural development signaling","description":"The top GO terms combine immune signaling (T cell receptor signaling, B cell differentiation) with neural and neural-development related processes (brain development, neurotrophin signaling, synapse assembly) and cytoskeletal regulation (positive regulation of actin filament polymerization, GTPase activity). This suggests a broad theme of developmental signaling and cytoskeletal dynamics across immune and nervous system contexts, with some involvement in organ development (heart, thymus). There isn\u2019t a single cohesive pathway linking all terms, so the label reflects a general umbrella of development-related signaling spanning immune and neural systems.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":4},{"id":"GO:0032959","count":4},{"id":"GO:0002316","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0030838","count":4}]},{"hash":"1230263559703414981","title":"Antiviral innate immunity and NF-kappaB signaling","description":"The top GO terms indicate a cohesive antiviral/innate immune module, with defense response to virus, innate immune response, and positive regulation of canonical NF-kappaB signaling. Additional terms point to cytoskeletal dynamics (ruffle assembly, actin polymerization) and endocytosis, which are often involved in immune signaling and pathogen uptake. Together they suggest proteins coordinating antiviral defense with NF-kappaB\u2013driven transcription and cytoskeleton remodeling. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051607","count":7},{"id":"GO:0051092","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0030433","count":5},{"id":"GO:0046597","count":5}]},{"hash":"1641282213367534257","title":"Ribosome Biogenesis and Translation","description":"The top GO terms overwhelmingly point to ribosome biogenesis and translation (including cytoplasmic translation and ribosomal subunit biogenesis/export), suggesting these proteins primarily function in ribosome assembly and protein synthesis. The presence of cell division and septum assembly terms aligns with growth linked to ribosome activity, while stress-response terms appear minor by comparison. Confidence: High","confidence":"","size":13,"edges":29,"triangles":25,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0006412","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0042274","count":4},{"id":"GO:0002181","count":4}]},{"hash":"713126842090974267","title":"Cytoskeleton remodeling under cellular stress","description":"This cluster is dominated by GO terms related to microtubule and actin dynamics (microtubule polymerization, microspike assembly, mitotic spindle assembly) and Rho signaling, alongside stress response and apoptotic pathways (hypoxia and ER stress\u2013related apoptosis). Ubiquitination adds a regulatory layer, but the core theme appears to be the cytoskeletal remodeling that occurs during cellular stress and the associated apoptotic signaling. Some terms (histone acetylation, gonad development) are less central, but do not dominate the cluster.","confidence":"Medium","size":13,"edges":17,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":3},{"id":"GO:0031116","count":2},{"id":"GO:0071456","count":2},{"id":"GO:0070059","count":2},{"id":"GO:0030035","count":2}]},{"hash":"2273982104404727045","title":"Hair Keratinization and Hair Cycle","description":"The top GO terms are keratinization and hair cycle, which together point to hair follicle biology and keratinocyte differentiation. This cluster likely contains proteins involved in keratin filament assembly and the hair shaft formation as well as the cyclical growth phases of hair follicles, indicating a cohesive hair-related structural and developmental function.","confidence":"High","size":13,"edges":57,"triangles":125,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":13},{"id":"GO:0042633","count":13}]},{"hash":"230627411384550277","title":"Keratinization and Epidermal Remodeling","description":"This cluster is driven by keratinization (GO:0031424) with the strongest signal, pointing to epidermal differentiation and skin-related processes. Additional signals, such as epithelial-to-mesenchymal transition, sprouting angiogenesis and endothelial proliferation, as well as innate immune response participation, suggest a broader context of tissue remodeling and wound healing where keratinocytes interact with vasculature and immune components. Some lipid metabolism and circadian terms are present but less central. Overall, the dominant theme is keratinocyte differentiation with remodeling aspects.","confidence":"Medium","size":13,"edges":32,"triangles":40,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":6},{"id":"GO:1905053","count":2},{"id":"GO:0021510","count":1},{"id":"GO:0001935","count":1},{"id":"GO:0002040","count":1}]},{"hash":"2144850208064403075","title":"GPCR Signaling Regulation","description":"The top GO terms converge on regulation of GPCR signaling pathways, including adenylate cyclase-inhibiting serotonin receptor signaling and general GPCR signaling regulation, with supporting themes of cardiovascular and neural influence (heart contraction regulation, smooth muscle contraction, dopamine secretion). Although there are no reported edges, the consistent annotations suggest a cluster of proteins involved in GPCR-mediated signaling cascades affecting cardiovascular and neuroimmune functions. This makes GPCR Signaling Regulation a coherent and representative label for the cluster.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":13},{"id":"GO:0031649","count":13},{"id":"GO:2000420","count":13},{"id":"GO:0001997","count":13},{"id":"GO:0045745","count":13}]},{"hash":"1395604615381626725","title":"Thermogenesis and Temperature Response","description":"This cluster is dominated by GO terms for heat generation, diet-induced thermogenesis, and cellular response to temperature stimulus, pointing to proteins involved in thermogenic and temperature-sensing pathways. While other terms touch on GPCR signaling and cardiovascular regulation, the strongest signal centers on thermogenesis and temperature response.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":13},{"id":"GO:0019233","count":13},{"id":"GO:0071502","count":13},{"id":"GO:0033861","count":12},{"id":"GO:0031649","count":12}]},{"hash":"262825653040598200","title":"GPCR signaling in cardiovascular and immune regulation","description":"This cluster centers on GPCR-mediated signaling linked to cardiovascular and immune functions. The top GO terms include positive regulation of GPCR signaling, serotonin receptor signaling and catecholamine effects on heart contraction, plus vascular smooth muscle contraction and dopamine secretion regulation. Additional terms point to immune cell behavior such as dendritic cell chemotaxis and eosinophil extravasation regulation. Together, they suggest a coherent theme of GPCR-driven communication across heart/vascular tissue and immune-related cell migration.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":13},{"id":"GO:0031649","count":13},{"id":"GO:2000420","count":13},{"id":"GO:0001997","count":13},{"id":"GO:0045745","count":13}]},{"hash":"1658060845474564951","title":"Autonomic cardiovascular GPCR signaling","description":"This cluster is dominated by terms tied to autonomic regulation of cardiovascular function: heart contraction modulation by catecholamines, vascular smooth muscle contraction, and GPCR signaling pathways (including GPCR signaling regulation and adenylate cyclase-inhibiting serotonin signaling). Dopamine secretion regulation and dendritic cell chemotaxis appear as related signaling roles, but the clearest theme is GPCR-mediated control of heart and vessel function. Confidence: High","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":13},{"id":"GO:0031649","count":13},{"id":"GO:2000420","count":13},{"id":"GO:0001997","count":13},{"id":"GO:0045745","count":13}]},{"hash":"1234061727854672034","title":"Cell Cycle and Stress Response Machinery","description":"The cluster is enriched for cell cycle and division-related terms (cell cycle, cell division, negative regulation of G0 to G1 transition) alongside telomere maintenance and mRNA processing, pointing to proteins involved in proliferation and genome maintenance. Additional signals for cellular stress responses (response to heat, cellular response to hypoxia) suggest the same proteins may participate in stress-adaptive regulation of growth. A few terms like protein homooligomerization are general and could reflect structural or assembly roles common to these pathways. Overall, the set represents a proliferation-centered module with genome stability and RNA processing components.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007049","count":4},{"id":"GO:0009408","count":4},{"id":"GO:0010745","count":4},{"id":"GO:0006397","count":4},{"id":"GO:0021707","count":4}]},{"hash":"1667821321199894367","title":"Schwann cell development and peripheral myelination","description":"GO terms converge on Schwann cell lineage and peripheral nervous system myelination, with calcium signaling components (calcium detection and calcineurin-NFAT regulation) suggesting calcium-dependent control of Schwann differentiation. The presence of EMT hints at neural crest-derived glial development, supporting a neural crest\u2192Schwann cell theme.","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051533","count":4},{"id":"GO:0032516","count":4},{"id":"GO:0001837","count":4},{"id":"GO:0014044","count":4},{"id":"GO:0022011","count":4}]},{"hash":"1006403074880769131","title":"Neurocardiovascular GPCR signaling","description":"The top terms cluster around GPCR signaling with downstream effects on heart contraction via catecholamines (epinephrine/norepinephrine), vascular smooth muscle regulation, and dopamine secretion; additional terms hint at neuromodulatory-immune interactions (e.g., dendritic cell chemotaxis). This suggests a cohesive module of GPCR-driven signaling coordinating neurocardiovascular function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":13},{"id":"GO:0031649","count":13},{"id":"GO:2000420","count":13},{"id":"GO:0001997","count":13},{"id":"GO:0045745","count":13}]},{"hash":"121220093905562407","title":"TLR/MyD88-Driven Inflammatory Signaling","description":"This cluster is dominated by terms related to innate immune activation: lipopolysaccharide-mediated signaling, MyD88-dependent TLR signaling, TNF/IL-6 responses, and inflammatory signaling, with coordination to macrophage differentiation and PI3K-Akt pathways. These together point to a cohesive theme of TLR/NF-\u03baB\u2013mediated inflammation.","confidence":"High","size":13,"edges":12,"triangles":0,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0031663","count":8},{"id":"GO:0032760","count":7},{"id":"GO:0002755","count":7},{"id":"GO:0006954","count":7},{"id":"GO:0071260","count":7}]},{"hash":"372779662072343586","title":"Neuronal development and epithelial morphogenesis","description":"Although the top GO terms are mixed, they cluster around developmental processes across neural and epithelial lineages: synaptic transmission and dendritic spine development, gliogenesis, and hair follicle morphogenesis and mammary gland epithelial proliferation. This pattern suggests proteins involved in signaling and morphogenesis during tissue development rather than a single pathway, justifying a label that encompasses both neural development and epithelial morphogenesis.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033601","count":2},{"id":"GO:0031069","count":2},{"id":"GO:0034394","count":1},{"id":"GO:0032224","count":1},{"id":"GO:0007271","count":1}]},{"hash":"1591433907800428483","title":"Unknown","description":"The terms span multiple unrelated processes (vertebrate development, stress responses, apoptosis, and even plant hormone signaling) with no clear common function, so a single coherent label cannot be assigned to the cluster.","confidence":"","size":12,"edges":28,"triangles":16,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070640","count":12},{"id":"GO:0072709","count":12},{"id":"GO:0000196","count":12},{"id":"GO:0060484","count":12},{"id":"GO:0006915","count":12}]},{"hash":"395197801567815305","title":"Neural development and transcriptional regulation","description":"This cluster shows strong enrichment for transcription-related GO terms (RNA polymerase II\u2013mediated transcription and its regulation) alongside multiple embryonic neural and sensory organ development terms (rhombomere 5 development, brain segmentation, habenula and eye morphogenesis) and estrogen signaling. Together, these indicate a group of proteins coordinating transcriptional control during neural/brain development with involvement in developmental signaling pathways. ","confidence":"High","size":12,"edges":43,"triangles":66,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0031167","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0021571","count":3},{"id":"GO:0035284","count":3}]},{"hash":"394618210466100426","title":"Developmental morphogenesis and signaling","description":"The top GO terms cluster around morphogenesis and development (cell morphogenesis, cerebellar Purkinje layer morphogenesis, lung-associated mesenchyme development), with a clear signaling component (peptidyl-threonine phosphorylation, MAPK cascade) and emphasis on regulatory processes like proteasomal degradation, apoptosis, and mitotic cell cycle\u2014together suggesting a set of proteins coordinating development through signaling and protein turnover.","confidence":"Medium","size":12,"edges":54,"triangles":123,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000902","count":4},{"id":"GO:0018107","count":4},{"id":"GO:0032436","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0070640","count":3}]},{"hash":"423684984980781214","title":"Immune signaling and transcription regulation","description":"The cluster shows strong enrichment for immune-related GO terms (T cell receptor signaling, LPS response, GM-CSF stimulus) along with DNA-templated transcription and regulatory processes like NF-kappaB activity, suggesting proteins that participate in immune signaling and transcriptional control. Some terms about development (trachea formation, FSH stimulus) are present but less central, likely reflecting shared signaling or broad regulatory roles.","confidence":"High","size":12,"edges":42,"triangles":67,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050852","count":8},{"id":"GO:0071222","count":8},{"id":"GO:0097011","count":8},{"id":"GO:0006351","count":8},{"id":"GO:0046827","count":7}]},{"hash":"239884399766216167","title":"Neural Crest and Heart Morphogenesis","description":"The cluster\u2019s GO terms cluster around embryonic development with emphasis on neural crest differentiation, neural-crest\u2013derived structures (e.g., lateral line neuromasts, brainstem-related processes), and heart/foregut formation, along with regulation of BMP signaling and ECM assembly. This points to coordinated neural crest\u2013driven organogenesis, including heart and foregut morphogenesis, rather than a single isolated function.","confidence":"High","size":12,"edges":21,"triangles":17,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0003360","count":2},{"id":"GO:0030514","count":2},{"id":"GO:0048922","count":2},{"id":"GO:0060030","count":2},{"id":"GO:1901203","count":2}]},{"hash":"1408680616237925848","title":"Mitotic spindle dynamics and cytokinesis","description":"These proteins are strongly linked to mitotic spindle function and cell division: plus-end directed microtubule sliding, kinetochore attachments, spindle midzone assembly, chromosome alignment during metaphase, and cytokinesis. Some terms touch on broader cytoskeletal organization and tissue-specific roles, but the core signal is spindle assembly and mitosis.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0031535","count":12},{"id":"GO:0099607","count":12},{"id":"GO:0030951","count":12},{"id":"GO:0051255","count":12},{"id":"GO:0000911","count":12}]},{"hash":"275909116820963784","title":"Unknown","description":"Top terms are highly diverse (circadian rhythm, B and T cell signaling, ubiquitination regulation, phototropism, distal tubule morphogenesis) with no clear common function, and there are no edges linking the proteins, plus some obsolete terms. This mix provides no coherent biological theme to assign a specific, representative label.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904431","count":3},{"id":"GO:0042748","count":3},{"id":"GO:0043380","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0031397","count":3}]},{"hash":"1693800137424798103","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006368","count":2},{"id":"GO:0043627","count":2},{"id":"GO:0006398","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0098789","count":2}]},{"hash":"2240564420824727045","title":"Immune Signaling and Phagocytosis","description":"The cluster is enriched for terms tied to immune function, including innate immune response, phagocytosis (recognition and engulfment), and B cell activation/signaling, plus regulation of kinase activity and xenobiotic response. While neural terms like myelination and regulation of synapse assembly appear, the dominant theme across most terms is immune cell signaling and phagocytic activity, suggesting these proteins function together in immune responses with possible ancillary neural associations.","confidence":"Medium","size":12,"edges":13,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":3},{"id":"GO:0032516","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0071902","count":3},{"id":"GO:0006911","count":2}]},{"hash":"2289752319244569523","title":"RNA Processing and Transcription Regulation","description":"The top GO terms cluster around RNA metabolism and transcription control, including splicing regulation, mRNA export, transcription termination, transcription-coupled repair, and ncRNA-mediated gene silencing, with stress granule localization indicating cytoplasmic RNA handling and rRNA maturation linking to ribosome biogenesis. A peripheral term on meiotic gene conversion does not override the central RNA-centric theme. ","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7},{"id":"GO:1901407","count":6},{"id":"GO:1903608","count":6},{"id":"GO:0006369","count":6}]},{"hash":"2212468879664961585","title":"Vacuolar amino acid transport","description":"The terms consistently describe transmembrane import of multiple amino acids into the vacuole, plus regulation of amino acid transport, indicating a cohesive function of vacuolar amino acid sequestration in plants. A root cap term appears peripheral.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0089708","count":5},{"id":"GO:0090515","count":5},{"id":"GO:2000487","count":5},{"id":"GO:0090514","count":5},{"id":"GO:1901482","count":5}]},{"hash":"2025845765293503593","title":"MAPK signaling and stress-responsive development","description":"The top terms cluster around the ERK1/ERK2 cascade (MAPK signaling), regulation of GTPase activity, stress-related mRNA stability, and amino acid\u2013driven responses, along with several developmental processes (gland morphogenesis, osteoblast differentiation, digestive tract development). Together these suggest proteins involved in MAPK-mediated signaling that integrates stress/nutrient cues to influence developmental regulation.","confidence":"Medium","size":12,"edges":25,"triangles":27,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0098908","count":2},{"id":"GO:0010610","count":2},{"id":"GO:0070371","count":2},{"id":"GO:0051092","count":2}]},{"hash":"2229598381616979565","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":65,"triangles":210,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:1905608","count":6},{"id":"GO:0072356","count":6},{"id":"GO:0031291","count":6},{"id":"GO:0051036","count":6}]},{"hash":"381414011097843569","title":"Genome maintenance and mitotic control","description":"This cluster centers on DNA repair (global genome nucleotide-excision repair, repair regulation) and cell-cycle control (chromosome segregation, G2/M transition, exit from mitosis), with related ubiquitin-mediated proteolysis and apoptosis signals. While viral-process and sperm-axoneme terms appear, the dominant theme ties genome integrity maintenance to mitotic regulation and protein turnover.","confidence":"Medium","size":12,"edges":63,"triangles":193,"max_degree":11,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0070911","count":12},{"id":"GO:0007059","count":12},{"id":"GO:0016032","count":12},{"id":"GO:0000086","count":12},{"id":"GO:0010458","count":12}]},{"hash":"363813157772664044","title":"DNA Damage Response and Mitotic Regulation","description":"This cluster centers on genome maintenance and cell-cycle control, with strong signals for nucleotide-excision repair, DNA repair, chromosome segregation, G2/M transition, and mitotic exit, along with ubiquitin-mediated proteolysis and ubiquitin chain formation. Apoptosis is a downstream connection, and the viral process term likely reflects host\u2013virus interactions with these pathways. The sperm axoneme assembly term is a weaker outlier but may relate to shared cytoskeletal components. ","confidence":"High","size":12,"edges":65,"triangles":210,"max_degree":11,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0070911","count":12},{"id":"GO:0007059","count":12},{"id":"GO:0016032","count":12},{"id":"GO:0000086","count":12},{"id":"GO:0010458","count":12}]},{"hash":"1144276395047929786","title":"Fungal ergosterol and lipid biosynthesis","description":"This cluster is enriched for lipid metabolism and membrane-related processes seen in fungi: regulation of ergosterol biosynthetic process, unsaturated fatty acid biosynthesis, and mannosyl-inositol phosphorylceramide metabolic process. While some terms (nitrate assimilation, nitric oxide, mitochondrion inheritance) are less specific to lipids, the dominant signal points to fungal sterol and lipid biosynthesis pathways, supporting a fungal membrane lipid theme. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":7},{"id":"GO:0006675","count":6},{"id":"GO:0032443","count":6},{"id":"GO:0000001","count":6},{"id":"GO:0006636","count":6}]},{"hash":"1815662949675307401","title":"RNA processing and translation initiation","description":"The GO terms cluster around RNA metabolism\u2014splicing (spliceosome), mRNA export, and mRNA modification\u2014along with translation initiation/reinitiation, suggesting these proteins participate in RNA maturation and control of translation.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0000398","count":4},{"id":"GO:0050830","count":3},{"id":"GO:0035264","count":3}]},{"hash":"636450557555494616","title":"Mitotic spindle assembly and cytokinesis","description":"The top GO terms cluster around mitosis and cell division: mitotic cell cycle, spindle assembly, division septum/cytokinesis, exit from mitosis, and meiosis-related spindle assembly. Some terms about polarity and ER polarization are linked to division orientation, but the dominant signal is mitotic/meiotic chromosome segregation and cytokinesis.","confidence":"High","size":12,"edges":30,"triangles":28,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051291","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0000917","count":6},{"id":"GO:0010458","count":6},{"id":"GO:0030011","count":6}]},{"hash":"165918182177934761","title":"Unknown","description":"The top GO terms are a highly diverse mix: Wnt signaling; transcriptional regulation; axis specification; tRNA processing; hormonal and vitamin D responses; neuron differentiation; lipopolysaccharide signaling; adipocyte differentiation; cloacal septation. There is no obvious unifying function or pathway tying the 12 proteins together, and the representation is sparse across many processes rather than concentrated in a single biological theme.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0007313","count":2},{"id":"GO:0008033","count":2},{"id":"GO:0071372","count":2}]},{"hash":"1003354971082186260","title":"Dopaminergic Signaling and Neural Development","description":"This cluster is characterized by dopamine-related activity, with GO terms for dopamine biosynthesis and positive regulation of dopamine metabolism, and for neural precursor proliferation, suggesting a theme around dopaminergic signaling and neural development. Additional terms related to spliceosome-mediated splicing and apoptosis indicate broader neuronal regulatory processes, but the dopamine and neural development signals are most prominent.","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0000380","count":1},{"id":"GO:0014063","count":1},{"id":"GO:0042416","count":1},{"id":"GO:0010269","count":1},{"id":"GO:0006915","count":1}]},{"hash":"2252474481141039666","title":"Ribosome Biogenesis and Translation","description":"It centers on translation and ribosome biogenesis (translation, ribosome biogenesis, translational elongation, tRNA modification, mRNA decay) with incidental links to the secretory pathway (SNARE disassembly, ER-to-Golgi transport), indicating a core protein synthesis machinery theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0035494","count":4},{"id":"GO:0009086","count":3},{"id":"GO:0002181","count":3},{"id":"GO:0045901","count":3}]},{"hash":"1751534584208041727","title":"Unknown","description":"The GO terms span muscle development, ubiquitin-related protein turnover, circadian rhythm, immune signaling (B and T cell differentiation), plant phototropism, and distal tubule morphogenesis, showing no clear, single-function theme tying the proteins together. With no edges or triangles and mixed processes, a coherent label cannot be assigned beyond Unknown.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":5},{"id":"GO:0042787","count":5},{"id":"GO:1904431","count":4},{"id":"GO:0042748","count":4},{"id":"GO:0043380","count":4}]},{"hash":"1907943618634816272","title":"Membrane Transporters","description":"This cluster is dominated by transmembrane transport GO terms for various nutrients and ions (D-glucose, pantothenate, myo-inositol, biotin, nitrite) and ion transport (sodium and potassium). Although a couple of biosynthetic processes (acetylcholine, cortisol, aldosterone) appear, the strongest signal is membrane transport of small molecules and ions, suggesting these proteins function as transporters.","confidence":"High","size":12,"edges":11,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":4},{"id":"GO:0071436","count":3},{"id":"GO:0015887","count":3},{"id":"GO:0015798","count":3},{"id":"GO:0015878","count":3}]},{"hash":"792450044760095760","title":"Neural and cardiac development with Rho signaling","description":"The cluster is dominated by GO terms for heart, brain, nervous system, and skeletal development, indicating a broad developmental theme. Coupled with enriched Rho protein signal transduction and positive regulation of GTPase activity, the proteins likely coordinate cytoskeletal dynamics and signaling pathways essential for tissue morphogenesis and neural/heart development. Calcium-dependent exocytosis regulation also supports roles in neuronal signaling, aligning with brain development. Overall, the common thread is developmental processes orchestrated by Rho-GTPase signaling.","confidence":"High","size":12,"edges":62,"triangles":183,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":12},{"id":"GO:0007399","count":12},{"id":"GO:0007266","count":12},{"id":"GO:0043547","count":12},{"id":"GO:0001501","count":12}]},{"hash":"431736517691063484","title":"Rho-Driven Actin Remodeling and Cell Migration","description":"The cluster is dominated by GO terms tied to Rho GTPase signaling and actin cytoskeleton dynamics, including regulation of GTPase activity, lamellipodium and filopodium assembly, and actin filament bundle formation, all linked to cell migration and adhesion. Endosome localization and epithelial polarity establishment suggest coordination between trafficking and cytoskeletal organization in movement and polarity. Overall, this set reflects a module centered on actin-driven protrusion and migratory behavior.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0036010","count":6},{"id":"GO:0051017","count":6},{"id":"GO:0016477","count":6}]},{"hash":"1696590934787678363","title":"Ribosome Biogenesis and Nuclear Gene Expression","description":"This cluster is dominated by GO terms for ribosome biogenesis and translation, with supporting terms related to nuclear gene expression (DNA-templated transcription, mRNA export, transcription elongation) and DNA replication, suggesting proteins involved in ribosome production and broader nuclear RNA production/processing machinery.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006406","count":2}]},{"hash":"492099505790728113","title":"Spliceosome-Mediated mRNA Processing","description":"This cluster is defined by nuclear mRNA maturation and splicing: numerous terms for spliceosome-driven splicing, splice-site recognition, and alternative splicing regulation. Additional terms cover mRNA export, modification, and poly(A) tail shortening, indicating coordinated transcript maturation and trafficking. The presence of stress-related mRNA stability and translation reinitiation suggests broader post-transcriptional control linked to these processing steps. Together, these terms point to a cluster centered on splicing and maturation of nuclear mRNA.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":12},{"id":"GO:0006406","count":9},{"id":"GO:0000380","count":9},{"id":"GO:0060211","count":9},{"id":"GO:0045292","count":9}]},{"hash":"2193550827302948980","title":"DNA Replication and Repair Cluster","description":"This cluster is dominated by GO terms related to DNA replication and repair, including DNA replication, lagging/leading strand elongation, nucleotide-excision repair, and DNA synthesis in homologous recombination repair, pointing to a core role in genome duplication and maintenance. A couple of terms like vitamin D3 metabolic process and cellular response to sorbitol are likely peripheral annotations or noise. Overall, the theme is cohesive around replication and repair functions. ","confidence":"High","size":12,"edges":12,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0007118","count":2},{"id":"GO:0000011","count":2},{"id":"GO:1903459","count":1},{"id":"GO:1904161","count":1}]},{"hash":"1843132283750160944","title":"Hair cycle and keratinization","description":"The top GO terms are directly related to hair biology, namely the hair cycle and keratinization, indicating this cluster centers on hair follicle structure and hair shaft formation processes.","confidence":"High","size":12,"edges":64,"triangles":201,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0042633","count":8},{"id":"GO:0031424","count":7}]},{"hash":"1154689232643583005","title":"Ribosome Biogenesis and Cell Division","description":"The top GO terms are dominated by cytoplasmic translation, ribosome biogenesis, tRNA modification, and ribosomal subunit export from the nucleus, indicating a core theme of ribosome production and protein synthesis. Additional terms like cell cycle, cell division, and cell septum assembly suggest coupling to growth and cytokinesis, with the conjugation with cellular fusion term pointing to a yeast-like mating/cytokinesis context. Together, these imply a coherent cluster of ribosome assembly machinery linked to cell-cycle progression and division.","confidence":"High","size":12,"edges":14,"triangles":0,"max_degree":5,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0002181","count":5},{"id":"GO:0042254","count":5},{"id":"GO:0006400","count":5},{"id":"GO:0000055","count":5},{"id":"GO:0051301","count":5}]},{"hash":"960541477502023838","title":"Actin-driven mitosis and organelle inheritance","description":"This cluster centers on actin cytoskeleton\u2013mediated processes linked to cell division and cargo/organelle trafficking. The top GO terms emphasize spindle assembly, mitotic contractile ring actomyosin localization, vesicle transport along actin, and organelle inheritance (vacuole and mitochondrion). A few terms mention secretory granule localization and VEGF\u2011regulated migration, suggesting broader actin-regulated trafficking, but the strongest cohesive theme is actin-based mitosis and inheritance.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":2},{"id":"GO:1903478","count":2},{"id":"GO:0038089","count":2},{"id":"GO:1902405","count":2},{"id":"GO:0030050","count":2}]},{"hash":"889672465287579464","title":"Spliceosome-Driven mRNA Splicing and Export","description":"The dominant GO signals cluster around spliceosome-mediated splicing, mRNA processing, export, and related maturation steps, indicating a nuclear RNA-processing module.","confidence":"High","size":12,"edges":34,"triangles":58,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":10},{"id":"GO:0031047","count":10},{"id":"GO:0006376","count":9},{"id":"GO:1901407","count":9},{"id":"GO:0006406","count":8}]},{"hash":"1610362955453570158","title":"Unknown","description":"The Top Terms are scattered across vision (visual perception and learning), heart/membrane potential regulation, sensory pain, immune and inflammatory responses, and dsRNA sensing. This distribution lacks a single clear biological theme or pathway linking the proteins, suggesting no cohesive functional cluster can be named meaningfully beyond Unknown.","confidence":"","size":12,"edges":58,"triangles":154,"max_degree":11,"top_function":"nervous system process","top_go_terms":[{"id":"GO:0043330","count":7},{"id":"GO:0071333","count":7},{"id":"GO:0098914","count":6},{"id":"GO:0060075","count":6},{"id":"GO:0008542","count":5}]},{"hash":"461897916620081780","title":"Neurovascular GPCR Signaling","description":"The terms cluster around GPCR-driven signaling and its downstream effects across cardiovascular, neural, and immune contexts (e.g., regulation of GPCR signaling, serotonin receptor signaling affecting adenylate cyclase, heart and vascular smooth muscle contraction, dopamine secretion regulation, and dendritic cell chemotaxis). This points to a shared function in modulating signaling pathways that influence neurovascular and immune processes via GPCRs.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":12},{"id":"GO:0031649","count":12},{"id":"GO:2000420","count":12},{"id":"GO:0001997","count":12},{"id":"GO:0045745","count":12}]},{"hash":"2216456315838615464","title":"Ion Transport and Metal Ion Homeostasis","description":"Most terms are about transport and homeostasis of metal ions (calcium, manganese, sodium, potassium), including calcium export and mitochondrial calcium homeostasis. A few terms concern skin/nail development and mesodermal differentiation, which may reflect tissue-specific contexts for ion balance. Overall, the cluster centers on ion transport and metal ion homeostasis.","confidence":"High","size":12,"edges":15,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006828","count":2},{"id":"GO:0007613","count":2},{"id":"GO:0035994","count":2},{"id":"GO:0035878","count":2},{"id":"GO:1990034","count":2}]},{"hash":"1714861991097603857","title":"GPCR Signaling Modulation in Cardiovascular and Immune Systems","description":"The top terms center on regulation and inhibition of GPCR signaling (including serotonin receptor pathways and GPCR signaling modulation), along with cardiovascular effects (heart contraction regulation, vascular smooth muscle contraction) and immune/neural processes (dendritic cell chemotaxis, dopamine secretion). This suggests a cohesive theme of GPCR-mediated signaling influencing cardiovascular function and immune cell behavior.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":11},{"id":"GO:0031649","count":11},{"id":"GO:2000420","count":11},{"id":"GO:0001997","count":11},{"id":"GO:0045745","count":11}]},{"hash":"1583089975064826496","title":"Epidermal Keratinization and Keratinocyte Differentiation","description":"The cluster\u2019s top GO terms cluster around skin-related differentiation and keratinization (epidermis development, keratinization, keratinocyte differentiation, peptide cross-linking), suggesting a module involved in epidermal barrier formation and keratin networks. While a few outliers (lens fiber differentiation, osteoblast differentiation, B cell receptor signaling) appear, they are less representative of the dominant epidermal theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008544","count":2},{"id":"GO:0031424","count":2},{"id":"GO:0018149","count":2},{"id":"GO:0030216","count":2},{"id":"GO:0001501","count":2}]},{"hash":"1847205835662899365","title":"Unknown","description":"GO terms are highly diverse across DNA structure, stress responses, cardiac signaling, immune differentiation, liver apoptosis, and endothelial barriers. There is no single coherent pathway or cellular context linking these terms, suggesting the proteins do not share a common, well-defined function in this cluster. Therefore Unknown.","confidence":"","size":12,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071919","count":2},{"id":"GO:0006970","count":2},{"id":"GO:0098907","count":2},{"id":"GO:0086070","count":2},{"id":"GO:0072660","count":2}]},{"hash":"2269971636127300885","title":"Protein and polyamine acetylation cluster","description":"The top GO terms are dominated by acetylation-related processes, including N-terminal and lysine acetylation as well as acetylation of polyamines like spermine and putrescine, suggesting a group enriched for acetyltransferase activities and acetylation modifications on various substrates. Supporting terms like mycothiol and glucosamine metabolism point to acetyl-CoA\u2013linked metabolic context that fuels acetylation reactions. A plant-specific term (regulation of leaf formation) appears less central to the core theme but may reflect broader regulatory links. ","confidence":"High","size":12,"edges":9,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046208","count":6},{"id":"GO:0017198","count":6},{"id":"GO:0018003","count":6},{"id":"GO:0010125","count":6},{"id":"GO:0032920","count":6}]},{"hash":"1308728144626711560","title":"Cardiac development and general cell differentiation","description":"The GO terms show a cluster of heart-related developmental signals (SA node signaling and cardioblast proliferation) plus typical developmental/differentiation processes (spindle assembly, spermatid differentiation, cell migration). This mix suggests a theme of developmental signaling with a noticeable cardiac focus, so the label Cardiac development and general cell differentiation is appropriate.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":6},{"id":"GO:0007289","count":6},{"id":"GO:0044707","count":5},{"id":"GO:0031382","count":5},{"id":"GO:2000340","count":5}]},{"hash":"1578169733859628603","title":"Developmental signaling and cholesterol transport","description":"The top GO terms cluster around developmental signaling (BMP response, Wnt signaling regulation, ventral spinal cord development, axis specification) and cholesterol handling/endocytosis (cholesterol transport, VLDL particle clearance). This suggests proteins that participate in coordinating signaling pathways with membrane trafficking and lipid metabolism, rather than a single narrow function.","confidence":"Low","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0021517","count":3},{"id":"GO:0010899","count":3},{"id":"GO:0071773","count":3},{"id":"GO:0034447","count":3}]},{"hash":"1873737850479804249","title":"DNA Damage Response and Cell Cycle Regulation","description":"Most terms cluster around cellular responses to damage and stress: DNA repair, mitotic cell cycle progression, apoptosis signaling, and wound healing; plus stress responses to cadmium. Some terms are developmental or otherwise less connected, but the dominant theme points to DNA damage response, cell cycle control, and cell fate decisions.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001843","count":3},{"id":"GO:0006349","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0001403","count":3},{"id":"GO:0071276","count":3}]},{"hash":"1473728102018946543","title":"Neural development and xenobiotic stress response","description":"Top GO terms point to brain development (forebrain, substantia nigra) and brain angiogenesis, along with corticosterone and xenobiotic stress responses, plus mitochondrial function. This combination suggests a cluster of proteins involved in neural development coupled with metabolic and detoxification/stress pathways, though a few terms are more general. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051412","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0033617","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0055114","count":2}]},{"hash":"1051622357276306753","title":"GPCR-Mediated Cardiovascular and Neuroimmune Signaling","description":"Top GO terms point to GPCR signaling modulation, downstream pathways like adenylate cyclase and GTPase activity, and effects on heart contraction and vascular smooth muscle, with accompanying neurotransmitter (serotonin/dopamine) signaling and immune-related processes (dendritic cell chemotaxis). This suggests a cohesive theme of GPCR-driven signal transduction linking cardiovascular regulation with neuroimmune communication.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":12},{"id":"GO:0031649","count":12},{"id":"GO:2000420","count":12},{"id":"GO:0001997","count":12},{"id":"GO:0045745","count":12}]},{"hash":"1704457440383201357","title":"Neural and Cardiac Signaling and Development","description":"This cluster centers on neural processes (short-term memory, synaptic potentiation) and cardiac context (regulation of heart rate, heart development), with broader signaling regulation (NF-kappaB signaling, mitochondrial calcium, protein phosphorylation) and gene regulation (chromatin binding). The mix suggests a general theme of signaling and regulatory mechanisms active in neural and cardiovascular-related contexts, with occasional vascular and transcriptional regulation components. Confidence: Medium","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007614","count":3},{"id":"GO:0060291","count":3},{"id":"GO:0002027","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0051561","count":3}]},{"hash":"568853533594055753","title":"B cell activation and adaptive immune signaling","description":"This cluster is dominated by terms tied to B cell receptor signaling, adaptive immune response, Fc receptor signaling, and positive regulation of B cell activation, with additional hints of T cell costimulation and IL-2 production. These together point to coordinated adaptive immune activation driven by B cells (with helper T cell involvement), even though there are some innate processes like phagocytosis and complement activation present as supporting context.","confidence":"High","size":12,"edges":4,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050853","count":10},{"id":"GO:0002250","count":9},{"id":"GO:0038095","count":9},{"id":"GO:1900042","count":9},{"id":"GO:0050871","count":9}]},{"hash":"1803844500754303253","title":"Unknown","description":"The top GO terms span diverse, unrelated developmental and signaling processes across different organisms (placenta and oocyte development, neutrophil chemotaxis, IL-2 production, cGMP signaling, cardiac muscle regulation, and even fungal development), with several obsolete terms and no shared functional theme. The lack of a cohesive function among the proteins (no edges, no clustering) suggests no meaningful single-label interpretation beyond Unknown.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001890","count":2},{"id":"GO:0032743","count":2},{"id":"GO:0060282","count":2},{"id":"GO:0010753","count":2},{"id":"GO:0030593","count":2}]},{"hash":"5249290708990285","title":"Developmental differentiation across tissues","description":"This cluster centers on developmental processes across diverse tissues: retina development, spinal cord neuron and oligodendrocyte cell fate specification, endocrine pancreas development, osteoblast and skeletal muscle differentiation, and transcription by RNA polymerase II as a core regulatory activity. Additional terms for calcium signaling and PERK-mediated unfolded protein response commonly accompany differentiating cells, suggesting a broad developmental program rather than a single pathway. Confidence in this cohesive theme is moderate.","confidence":"Medium","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":5},{"id":"GO:0060041","count":5},{"id":"GO:0002087","count":4},{"id":"GO:0002076","count":4},{"id":"GO:0071277","count":3}]},{"hash":"389977208044346710","title":"MHC I antigen presentation and interferon signaling","description":"The cluster is dominated by GO terms for antigen processing and presentation via MHC class I (TAP-dependent ER pathway) and for type I and II interferon signaling, along with regulation of T cell-mediated cytotoxicity and NK cell activity. This points to an immune surveillance module centered on antigen presentation and interferon-driven cytotoxic responses, despite one extraneous retina homeostasis term. ","confidence":"High","size":11,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001895","count":4},{"id":"GO:0002485","count":3},{"id":"GO:0001916","count":3},{"id":"GO:1904437","count":3},{"id":"GO:0042270","count":3}]},{"hash":"1158586797004162311","title":"Unknown","description":"The top GO terms span both nuclear processes (DNA replication, transcription elongation) and cytoplasmic/ER-associated activities (protein refolding, ER polarization, stress responses, stress granule disassembly), plus oxidative stress and some obsolete terms. This mix does not reveal a single, cohesive function for the cluster, so no clear label is evident.","confidence":"","size":11,"edges":4,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0070389","count":7},{"id":"GO:0035617","count":5},{"id":"GO:0000742","count":4},{"id":"GO:0000902","count":4}]},{"hash":"1922777184503215852","title":"Neuronal sensory signaling and dopaminergic drug response","description":"The top GO terms cluster around neural signaling and sensory processing, including dopaminergic synaptic transmission, ERK cascade regulation, visual perception/learning, pain perception, and behavioral responses to cocaine, which together point to neuronal signaling and plasticity in response to stimuli and drugs. Some terms like heart development or macrophage chemotaxis are less directly connected and may reflect pleiotropy or annotation noise, but the dominant theme is neural processing and drug-related plasticity.","confidence":"Medium","size":11,"edges":7,"triangles":2,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0008542","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0006468","count":6},{"id":"GO:0007601","count":6}]},{"hash":"1424074800435986449","title":"Neuronal signaling, brain development, and apoptosis.","description":"This cluster centers on neuronal signaling (neurotrophin TRK receptor signaling), brain morphogenesis (cerebellum development), and behavior-related regulation (grooming), with accompanying apoptosis and regulatory processes; while some terms are broader (GTPase regulation, insulin signaling), the dominant theme ties neural development and signaling to cell fate and behavior.","confidence":"Medium","size":11,"edges":6,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0048011","count":4},{"id":"GO:1903679","count":4},{"id":"GO:0001878","count":3},{"id":"GO:0060988","count":3},{"id":"GO:0051902","count":3}]},{"hash":"276610000316144035","title":"T cell signaling and antigen presentation regulation","description":"Based on the top GO terms, the proteins cluster around adaptive immune signaling (T cell receptor signaling) and regulation of antigen processing/presentation (MHC II), as well as related functions like phagocytosis and antibacterial humoral responses. Some terms (spermatid development, erythrocyte differentiation, protein refolding) appear less directly related, but the dominant pattern points to T cell\u2013centered immune regulation.","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":5},{"id":"GO:0007286","count":5},{"id":"GO:0055072","count":5},{"id":"GO:0019731","count":5},{"id":"GO:0045646","count":5}]},{"hash":"807900417189550418","title":"Unknown","description":"The 11 proteins are annotated with GO terms spanning redox homeostasis, neuronal apoptosis regulation, Wnt signaling, ubiquitin-dependent protein catabolism, calcium-dependent muscle contraction, cell polarity, and RNA transport, among others. These functions cover multiple, distinct pathways with no single cohesive theme connecting all terms, making a specific, representative cluster label difficult to justify.","confidence":"","size":11,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0010796","count":2},{"id":"GO:0031384","count":2},{"id":"GO:0043525","count":2},{"id":"GO:2000059","count":2}]},{"hash":"1507785303819025348","title":"Neuroimmune signaling regulation","description":"The cluster shows enrichment for inflammatory processes (inflammatory response, non-canonical NF-kappaB signaling) and neural development/communication (positive regulation of synapse assembly, axon guidance) along with cortisol response and regulation of kinase activity, suggesting proteins that coordinate immune signaling with neural signaling and stress hormone responses.","confidence":"Medium","size":11,"edges":21,"triangles":15,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019800","count":8},{"id":"GO:0006469","count":8},{"id":"GO:0061364","count":7},{"id":"GO:0051965","count":7},{"id":"GO:0042346","count":7}]},{"hash":"1833796071232810440","title":"Unknown","description":"The top GO terms cover highly diverse processes\u2014from brain and muscle development to actin organization, endocytosis, signaling, EMT, kinetochore localization, and even fungal spore wall assembly\u2014plus a hypoxia response. This broad mix lacks a single coherent function or theme tying the proteins together, so a specific biological label isn\u2019t defensible beyond Unknown.","confidence":"","size":11,"edges":50,"triangles":126,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0021762","count":4},{"id":"GO:0048741","count":4},{"id":"GO:0071456","count":3},{"id":"GO:0000147","count":3},{"id":"GO:0030476","count":3}]},{"hash":"141488494708708724","title":"Adaptive immune differentiation and inflammatory signaling","description":"This cluster features immune development and regulation terms (B cell differentiation, T cell proliferation, NK cell regulation, mast cell regulation) along with inflammatory processes (cell adhesion, wound healing regulation, and NF-kappaB signaling). The inclusion of Hedgehog/Smoothened signaling and serotonin secretion suggests additional developmental and neuroimmune context, but the dominant theme is adaptive immune cell differentiation coupled with inflammation and signaling. ","confidence":"High","size":11,"edges":10,"triangles":0,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001923","count":9},{"id":"GO:0051092","count":9},{"id":"GO:0048598","count":9},{"id":"GO:0002859","count":9},{"id":"GO:2000566","count":9}]},{"hash":"1729640055948995884","title":"Transcriptional Regulation and RNA Processing","description":"Most frequent terms cluster around transcription and RNA processing (DNA-templated transcription, transcription antitermination, termination regulation, and RNA Pol II CTD phosphorylation) with a notable subset on post-transcriptional RNA processing (pre-miRNA processing, miRNA catabolic process). A translation term is present but does not dominate, and developmental terms are ancillary. This suggests a cohesive theme of gene-expression regulation via transcriptional and RNA processing mechanisms.","confidence":"High","size":11,"edges":21,"triangles":21,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:1901407","count":3},{"id":"GO:0001825","count":2},{"id":"GO:1902219","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1819984595666680116","title":"Methylation and Cofactor Biosynthesis","description":"Most top terms point to methylation processes (N-terminal peptidyl-glycine methylation, rRNA methylation, peptidyl-lysine trimethylation/dimethylation) and SAM-dependent pathways (S-adenosylmethionine catabolic process), plus biosynthesis of cofactors like siroheme and cobalamin. While a couple of development terms appear, the predominant signal is methyltransferase activity and cofactor biosynthesis, suggesting a cohesive cluster of methylation-related enzymes and related biosynthetic processes.","confidence":"High","size":11,"edges":39,"triangles":60,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0021762","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0018013","count":2},{"id":"GO:0031167","count":2},{"id":"GO:0000183","count":2}]},{"hash":"284506180020722966","title":"Mitochondrial Transport and Metabolism","description":"The cluster is dominated by GO terms for transport across mitochondrial membranes (manganese ion, pyridoxal phosphate, citrate, ornithine, CoA) and a mitochondrial fission process, along with metabolic signaling related to insulin/IGF response. This pattern points to a group of mitochondrial transporters and regulators of mitochondrial metabolism that coordinate cofactor flux and energy-related signaling.","confidence":"High","size":11,"edges":20,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006828","count":5},{"id":"GO:0031921","count":5},{"id":"GO:0006843","count":5},{"id":"GO:0090149","count":5},{"id":"GO:0000066","count":5}]},{"hash":"427384247280141910","title":"Neural and Vascular Development Signaling","description":"The GO terms point to signaling pathways (RTK, IL-27) that regulate development and differentiation across neural and vascular contexts, including dendrite development, axon regeneration, pericyte differentiation, and lymphangiogenesis, with supporting terms for nephric duct and vagina morphogenesis. This suggests a cohesive theme of developmental signaling guiding neural and vascular differentiation, justifying the label.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007169","count":7},{"id":"GO:0006915","count":7},{"id":"GO:0050773","count":7},{"id":"GO:0072178","count":7},{"id":"GO:0070106","count":7}]},{"hash":"1718373507166173053","title":"Innate immune response to pathogens","description":"The top GO terms center on cellular responses to lipopolysaccharide and dsRNA, innate immunity, defense against virus and Gram-positive bacteria, and interferon-beta production, all pointing to innate pathogen defense and antiviral signaling as the cluster\u2019s core function. A few terms about synapse assembly and myelination are present but appear peripheral to the main immune theme. Overall, the cluster is best described as innate immune signaling against pathogens.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":5},{"id":"GO:0043330","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0051607","count":4},{"id":"GO:0031663","count":4}]},{"hash":"1404570480500152472","title":"Neuronal Vesicle Trafficking & Ephrin Signaling","description":"This cluster centers on vesicle transport and signaling related to neurons: synaptic vesicle maturation, endosome- and lysosome-trajectory trafficking, and ephrin receptor signaling. While a couple terms (heart development, ossification) seem less related, the dominant functions point to synaptic transport and ephrin-mediated signaling pathways.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":3},{"id":"GO:0048013","count":3},{"id":"GO:0016188","count":2},{"id":"GO:0035646","count":2},{"id":"GO:0006886","count":2}]},{"hash":"95695439055877936","title":"Neural and ectodermal organogenesis","description":"This cluster is enriched for nervous system development terms (including substantia nigra development) and ectoderm-derived organ formation such as hair follicles and salivary glands. The presence of Wnt signaling regulation and epithelial proliferation/polarity terms suggests coordinated morphogenesis, tying neural development with skin and gland formation. Collectively, these proteins likely function in early development and patterning of neural and ectodermal tissues.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":5},{"id":"GO:0031532","count":5},{"id":"GO:0090263","count":5},{"id":"GO:0031069","count":4},{"id":"GO:0060501","count":4}]},{"hash":"1648305554250422569","title":"Acetylation and polyamine metabolism","description":"The top GO terms cluster around acetylation events\u2014N-terminal, propionylation, and lysine acetylation\u2014as well as acetylation of polyamines (spermine, putrescine). This points to proteins involved in acetylation chemistry and polyamine turnover, with supporting metabolic terms like mycothiol and glucosamine biosynthesis. The subtelomeric heterochromatin term seems incidental and unlikely to define the cluster\u2019s core function. Overall, the theme is acetylation-focused metabolism and modification.","confidence":"High","size":11,"edges":27,"triangles":23,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":7},{"id":"GO:0046208","count":6},{"id":"GO:0017198","count":6},{"id":"GO:0018003","count":6},{"id":"GO:0010125","count":6}]},{"hash":"1553283112683007240","title":"Cell differentiation and morphogenesis signaling","description":"This cluster centers on differentiation and morphogenesis (fat cell differentiation, uterus morphogenesis, cell morphogenesis) and includes regulatory signaling (insulin receptor signaling, NFAT pathway) as well as cell-cycle control terms (mitotic cell cycle, negative regulation of CDK activity), suggesting a broad developmental signaling theme with accompanying cell-cycle and trafficking processes.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061038","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0034499","count":2},{"id":"GO:0051534","count":2},{"id":"GO:0000902","count":2}]},{"hash":"1835749426836984180","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0050427","count":3},{"id":"GO:0030573","count":2},{"id":"GO:0042403","count":2},{"id":"GO:0015012","count":2},{"id":"GO:0002002","count":2}]},{"hash":"1143037529521865463","title":"Multiorgan Development","description":"The cluster\u2019s top GO terms center on development across multiple organs and tissues (midbrain, liver, heart, palate, metencephalon, biomineral tissue), suggesting a broad developmental program. Some transcriptional regulation terms (positive/negative regulation of transcription by RNA polymerase II) further support a role in developmental gene regulation. Because the terms span several organs rather than a single pathway, a general label like Multiorgan Development best fits.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0030901","count":5},{"id":"GO:0001889","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0060021","count":4}]},{"hash":"783579740007090396","title":"Multisystem Signaling and Transcription Regulation","description":"The cluster centers on signaling pathways (e.g., MyD88-dependent TLR4 signaling) and regulation of transcription, with neural plasticity terms (long-term synaptic potentiation, memory, sensory perception of sound) suggesting brain-related signaling. While there are some terms tied to non-neural processes (acrosome reaction, muscle development), the common thread appears to be signaling events that influence gene expression across tissues, including the nervous system.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035660","count":4},{"id":"GO:0007527","count":4},{"id":"GO:0006355","count":4},{"id":"GO:0007340","count":2},{"id":"GO:0045792","count":2}]},{"hash":"2230967211738161911","title":"Developmental signaling and cell migration","description":"The proteins in this cluster show enrichment for developmental processes (axonal fasciculation, forebrain and mammary gland development, trophoblast migration) and regulation of signaling pathways (JAK-STAT, GTPase activity), plus factors related to cell communication and movement (contact inhibition, apoptosis). This suggests a cohesive theme around development and morphogenesis driven by signaling and cytoskeletal dynamics.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":2},{"id":"GO:0046426","count":2},{"id":"GO:0035307","count":1},{"id":"GO:0006915","count":1},{"id":"GO:0043547","count":1}]},{"hash":"156142079487656053","title":"Neural development and synaptic signaling","description":"The cluster\u2019s top terms are dominated by neural-related processes such as axonogenesis, visual learning, social behavior, and regulation of synapse assembly, as well as response to cocaine, suggesting a focus on neural development and synaptic connectivity. While other terms (translation, cell cycle, insulin/B cell signaling) appear, they are less central to the cluster\u2019s core theme. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0000082","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0007098","count":2}]},{"hash":"290303292080769098","title":"Innate Immune Signaling and Antiviral Regulation","description":"This cluster is dominated by immune-related terms: innate immune response, general immune response, and negative regulation of viral genome replication, plus positive regulation of STAT phosphorylation and macrophage differentiation, all pointing to signaling pathways driving antiviral defense and innate immune activation. A Golgi-to-ER vesicle transport term suggests common trafficking processes that can support signaling, while a couple of terms (maternal processes in pregnancy, adult locomotory behavior) appear less connected and may reflect annotation breadth or noise. Overall, the core theme is innate immune signaling and antiviral regulation.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045071","count":3},{"id":"GO:0045087","count":2},{"id":"GO:0046597","count":2},{"id":"GO:0045651","count":2},{"id":"GO:0033141","count":2}]},{"hash":"1039036932666036806","title":"Thermogenesis and GPCR-Driven Cardiovascular Regulation","description":"The top GO terms cluster around heat generation and temperature response (diet-induced thermogenesis, cellular response to temperature stimulus, heat generation) and are connected to cardiovascular control via GPCR signaling (positive regulation of GPCR signaling, vascular smooth muscle contraction, regulation of membrane potential, heart contraction modulation). This suggests a cohesive theme linking thermogenic processes with GPCR-mediated regulation of vascular tone and cardiac function.","confidence":"Medium","size":11,"edges":7,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":10},{"id":"GO:0019233","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0042391","count":9},{"id":"GO:0033861","count":8}]},{"hash":"604313839107537658","title":"GPCR Signaling in Immune and Cardiovascular Regulation","description":"This cluster centers on GPCR signaling and downstream pathways that regulate both cardiovascular responses (heart contraction, smooth muscle) and immune cell trafficking, with several GO terms directly describing GPCR signaling, serotonin/dopamine signaling, and dendritic cell chemotaxis. The shared theme is GPCR-mediated communication linking neural, vascular, and immune functions.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":11},{"id":"GO:0031649","count":11},{"id":"GO:2000420","count":11},{"id":"GO:0001997","count":11},{"id":"GO:0045745","count":11}]},{"hash":"770980180519753017","title":"Neurocardiovascular GPCR Signaling","description":"The top GO terms point to GPCR signaling and neuromodulatory pathways (dopamine/serotonin signaling, GPCR pathway regulation) with cardiovascular components (heart contraction regulation, smooth muscle contraction). There are broader immune signals (dendritic cell chemotaxis, eosinophil regulation) as well, but the common thread appears to be GPCR-mediated signaling affecting neural and vascular function rather than a single tight complex. However, the protein interactions are sparse, suggesting a broad signaling theme rather than a tightly connected module.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":11},{"id":"GO:0031649","count":11},{"id":"GO:2000420","count":11},{"id":"GO:0001997","count":11},{"id":"GO:0045745","count":11}]},{"hash":"860107381293951305","title":"GPCR-Mediated Cardiovascular and Neural Signaling","description":"This cluster centers on GPCR signaling and its downstream pathways, with GO terms for GPCR signaling, adenylate cyclase inhibition via serotonin receptors, and regulation of GTPase activity, alongside terms tied to cardiovascular regulation such as epinephrine/norepinephrine\u2013driven heart contraction and vascular smooth muscle contraction. Dopamine and serotonin signaling regulation, and dendritic cell chemotaxis, indicate neuromodulatory and immune-cell trafficking aspects modulated by GPCR pathways. Overall, it represents proteins involved in GPCR-driven cardiovascular and neural signaling with some immune modulation.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":11},{"id":"GO:0031649","count":11},{"id":"GO:2000420","count":11},{"id":"GO:0001997","count":11},{"id":"GO:0045745","count":11}]},{"hash":"304915367630682801","title":"Mitochondrial respiration and mitophagy","description":"The top GO terms point to mitochondrial energy metabolism: electron transport, ATP synthesis driven by the proton motive force, and complex I assembly, along with mitophagy and regulation of cellular respiration. A few terms like photosynthesis and fat cell differentiation appear but are likely noise; overall, the cluster centers on mitochondrial function and turnover.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006123","count":1},{"id":"GO:0045600","count":1},{"id":"GO:0032981","count":1},{"id":"GO:0015986","count":1},{"id":"GO:0099132","count":1}]},{"hash":"179291820395794030","title":"Lipid Biosynthesis with Immune Signaling","description":"The dominant GO terms point to lipid biosynthesis (ether lipids, triglycerides, CDP-diacylglycerol, cutin) and related lipid signaling (platelet activating factor), alongside energy metabolism (mitochondrial ATP synthesis) and immune modulation (IL-2 production, T cell death regulation). A unifying theme appears to be lipid metabolic pathways intersecting with immune signaling, with a few developmental terms likely reflecting broad roles in tissues.","confidence":"Medium","size":11,"edges":22,"triangles":19,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0002071","count":9},{"id":"GO:0042775","count":9},{"id":"GO:0070970","count":9},{"id":"GO:0006663","count":9},{"id":"GO:0008611","count":9}]},{"hash":"629633047424680289","title":"Developmental Morphogenesis and Signaling","description":"This cluster is driven by GO terms related to developmental processes, especially skin development and forebrain development, suggesting a theme around morphogenesis and tissue patterning. Additional terms point to broader cellular signaling and protein handling (GTPase activity, peroxisome targeting, rRNA maturation, etc.), implying coordinated regulation of development-associated pathways and protein localization. The lack of observed edges does not undermine the pattern, as GO annotations capture shared functional themes rather than direct interactions.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0043588","count":10},{"id":"GO:0010255","count":9},{"id":"GO:0006625","count":9},{"id":"GO:0035246","count":9},{"id":"GO:0000462","count":9}]},{"hash":"2036571013197566036","title":"Mesenchymal differentiation under oxidative stress","description":"The terms cluster around differentiation of mesenchymal lineages (endothelial, adipocyte, and myotube) and concurrent oxidative stress response and survival signaling (PI3K/AKT, anti-apoptotic regulation), suggesting a shared program of lineage differentiation modulated by redox signals.","confidence":"Medium","size":11,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0008631","count":2},{"id":"GO:0010269","count":1},{"id":"GO:0014902","count":1},{"id":"GO:0051897","count":1},{"id":"GO:0001885","count":1}]},{"hash":"1027565012528557398","title":"Nutrient Sensing and Metabolic Regulation","description":"Based on dominant GO terms such as insulin receptor signaling pathway, glucose metabolic process, cellular response to nutrient, and branched-chain amino acid catabolic process, the cluster appears to group proteins involved in sensing nutrient status and coordinating metabolic pathways. While some terms (telomerase assembly, chemotaxis) are less directly connected, the core pattern points to metabolic regulation in response to nutrient availability.","confidence":"Medium","size":11,"edges":4,"triangles":0,"max_degree":3,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0008286","count":4},{"id":"GO:0000122","count":3},{"id":"GO:0006006","count":3},{"id":"GO:1905323","count":3},{"id":"GO:0018105","count":3}]},{"hash":"1842107890012903730","title":"Translation Initiation and Chromatin Regulation","description":"The GO terms show a recurring theme of controlling gene expression at multiple levels: translation initiation (preinitiation complex formation and translational initiation) and chromatin-level regulation (histone H3K4 methylation, histone deacetylation, imprinting) along with RNA modification (guanine-N7 methylation). Although some terms are older or broader (ERAD, proliferation, invasive growth), the dominant signals point to a cluster centered on regulating expression from transcriptional/epigenetic to translational stages.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0006349","count":2},{"id":"GO:0051568","count":2}]},{"hash":"250825079446905058","title":"RNA Pol II Transcription Regulation and Stress Response","description":"The top GO terms cluster around DNA-templated transcription and RNA Polymerase II\u2013mediated transcription (initiation, snRNA transcription), indicating a transcriptional regulation module. Additional terms point to stress-related responses (ER unfolded protein response, cellular response to xenobiotic stimulus, hyperosmotic response) and cell cycle processes, suggesting these proteins participate in transcription control that is modulated during stress and division.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0006355","count":3},{"id":"GO:0035690","count":2},{"id":"GO:0006972","count":2},{"id":"GO:0006367","count":2}]},{"hash":"1719780456851693409","title":"Developmental differentiation and reproductive processes","description":"This cluster groups proteins involved in broad developmental signaling and tissue differentiation (e.g., Notch signaling, neural crest migration, odontogenesis, tendon differentiation, sarcomere organization) and includes reproductive biology terms (pregnancy, parturition). The common thread is developmental morphogenesis and differentiation across tissues, with reproductive processes alongside. Confidence: Medium","confidence":"","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007219","count":2},{"id":"GO:0035990","count":2},{"id":"GO:0007585","count":2},{"id":"GO:0035902","count":2},{"id":"GO:0007565","count":2}]},{"hash":"2041690552967724572","title":"Cardiovascular development and vascular remodeling","description":"The cluster\u2019s GO terms cluster around heart and blood vessel formation (ventricular trabecula morphogenesis, coronary artery morphogenesis), blood vessel remodeling, VEGF signaling, and Notch processing, with collagen fibril organization indicating ECM remodeling\u2014together pointing to cardiovascular development and associated ECM dynamics.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0032331","count":3},{"id":"GO:0060982","count":2},{"id":"GO:0010042","count":2}]},{"hash":"1431284624403724672","title":"Angiogenic Cytokine Signaling Regulators","description":"The most enriched terms are angiogenesis and cytokine-mediated signaling, pointing to secreted factors that coordinate blood vessel growth and immune communication. The presence of positive regulation of protein secretion supports a theme of secreted mediators, suggesting these proteins act together in pro-angiogenic cytokine signaling, even though some terms touch on broader signaling processes. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050714","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0019221","count":2},{"id":"GO:0043152","count":1},{"id":"GO:0051592","count":1}]},{"hash":"1923476209276584977","title":"Neddylation/Ubiquitin Signaling with Stress Response","description":"The top terms cluster around protein modification by neddylation and ubiquitin transferase activity, coupled with transcriptional regulation and responses to DNA-damaging stress (gamma radiation, UV-C), suggesting a unified theme of post-translational signaling and stress-responsive transcription.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":2},{"id":"GO:0014883","count":2},{"id":"GO:0014886","count":2},{"id":"GO:0051481","count":2},{"id":"GO:0006351","count":2}]},{"hash":"535707779335128480","title":"Nuclear proteostasis and gene expression","description":"The top GO terms point to nuclear processes such as DNA replication, DNA-templated transcription, and mRNA export, while simultaneously highlighting protein quality control roles like cellular response to misfolded proteins, aggresome assembly, and chaperone-related refolding/ERAD pathways. This combination suggests a cluster centered on nuclear gene expression machinery coupled with proteostasis mechanisms active in response to misfolded proteins. The presence of both replication/transcription and proteostasis terms supports a cohesive theme around nuclear function and protein quality control.","confidence":"Medium","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":7},{"id":"GO:0030433","count":5},{"id":"GO:0070389","count":5},{"id":"GO:0070842","count":5},{"id":"GO:0000902","count":4}]},{"hash":"275469391320477615","title":"Polyol and fatty acid oxidation","description":"The cluster includes GO terms for polyol catabolism (sorbitol, xylitol), ethanol catabolic/oxidation, and fatty acid omega-oxidation, with an additional retinol metabolic term. Together these points suggest a theme centered on oxidation-based metabolism of sugars, sugar alcohols, alcohols, and fatty acids, indicating a cohesive metabolic cluster rather than a random mix.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0042572","count":6},{"id":"GO:0046370","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0006068","count":4},{"id":"GO:0006069","count":4}]},{"hash":"1318079811565162752","title":"Cardiac development and SA node signaling","description":"This cluster shows multiple GO terms tied to heart development and pacemaker/conduction functions (Notch signaling in heart field cardioblast proliferation; regulation of SA node action potential; SA node to atrial communication), suggesting a common theme around cardiac development and rhythm regulation. Other terms like cell cycle and mRNA stability are broader but do not override the cardiac-related signals. Confidence: Medium","confidence":"","size":10,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":3},{"id":"GO:0043488","count":3},{"id":"GO:0044707","count":2},{"id":"GO:2000340","count":2},{"id":"GO:0003270","count":2}]},{"hash":"1736728266074067275","title":"Proteostasis and organelle trafficking","description":"This cluster centers on protein quality control, folding, and degradation (ERAD), with chaperone assembly and mitochondrial import, plus related vesicle formation, which together reflect cellular proteostasis and targeted trafficking; a few terms like mRNA export are peripheral.","confidence":"High","size":10,"edges":40,"triangles":86,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0018279","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0051131","count":4},{"id":"GO:0045041","count":4},{"id":"GO:0070651","count":4}]},{"hash":"367609525911303789","title":"mRNA splicing and processing complex","description":"This cluster is dominated by GO terms for mRNA splicing via the spliceosome, alternative splicing regulation, mRNA export, and related mRNA maturation processes, with a touch of translation initiation complex assembly, indicating a group of proteins involved in RNA processing and maturation that feeds into translation. ","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006406","count":7},{"id":"GO:0000380","count":7},{"id":"GO:0060211","count":7},{"id":"GO:0045292","count":7},{"id":"GO:0016556","count":7}]},{"hash":"535000385332111982","title":"Bacterial cell wall glycosylation and teichoic acid synthesis","description":"The top GO terms cluster around cell wall and extracellular polysaccharide biosynthesis (cellulose-like and teichoic acid biosynthesis, hyaluronan biosynthetic process, cell wall organization) and protein glycosylation pathways (O-linked to serine/threonine, N-acetyl-galactosamine), along with UDP-glucose metabolism and undecaprenyl phosphate\u2013dependent biosynthetic steps. This pattern points to a cohesive module dedicated to assembling and decorating cell wall/glycopolymer components in bacteria, rather than broad metabolic or signaling processes.","confidence":"High","size":10,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0030244","count":2},{"id":"GO:0019350","count":2},{"id":"GO:0018242","count":2},{"id":"GO:0006011","count":2},{"id":"GO:0071555","count":2}]},{"hash":"467532275234063264","title":"Ribosome Biogenesis and Translational Regulation","description":"The strongest signals are translation and ribosomal subunit assembly, plus circadian regulation of translation, which point to components of the protein synthesis machinery and its temporal control. Some metabolic and plant-development terms appear as secondary contexts (mitochondrial ATP synthesis, amino acid starvation, axillary shoot meristem initiation), but the core theme across the cluster is ribosome function and translational control.","confidence":"Medium","size":10,"edges":18,"triangles":19,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0006407","count":2},{"id":"GO:0000028","count":2},{"id":"GO:0097167","count":2},{"id":"GO:0042775","count":1}]},{"hash":"155464721884501477","title":"Embryonic Organ Morphogenesis","description":"This cluster centers on embryonic development and morphogenesis across multiple organs (pancreas, digestive tract, eye, limbs) and structures (neural crest, metencephalon, hindbrain). The co-occurrence of organogenesis and tissue patterning terms, plus transcriptional regulation terms, suggests a broad developmental program rather than a single pathway.","confidence":"High","size":10,"edges":12,"triangles":4,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048557","count":5},{"id":"GO:0090190","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0031018","count":5},{"id":"GO:0001755","count":5}]},{"hash":"1567296254698997046","title":"Proteolysis and Tissue Remodeling","description":"The Top Terms cluster points to proteolytic regulation and remodeling activities that tie development, coagulation, and immune contexts together. Positive regulation of plasminogen activation and cysteine-type endopeptidase activation suggest extracellular protease cascades driving matrix remodeling, which aligns with embryonic/implantation-related processes and amelogenesis, as well as coagulation. Immune-related terms are present but less central to the core theme of proteolysis-driven remodeling.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008360","count":2},{"id":"GO:0097186","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0019432","count":2},{"id":"GO:0007566","count":2}]},{"hash":"1530632954957305857","title":"Central carbon metabolism and amino acid biosynthesis","description":"These proteins cluster around core carbon metabolism: oxaloacetate metabolism, the TCA cycle, glyoxylate cycle, and gluconeogenesis, with adjacent amino acid biosynthesis and catabolism terms. A single transcription-related GO term appears but is not representative of the overall function. The dominant theme is carbon flux and amino acid metabolism, justifying the label.","confidence":"High","size":10,"edges":23,"triangles":31,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0006107","count":4},{"id":"GO:0006099","count":3},{"id":"GO:0006097","count":3},{"id":"GO:0006351","count":3}]},{"hash":"1696535185524441969","title":"Innate and adaptive immune activation with phagocytosis","description":"The top GO terms center on phagocytosis and immune responses, including innate immunity, complement activation, antibacterial humoral responses, and B cell activation/signaling, indicating a cluster devoted to immune activation with phagocytic activity spanning both innate and adaptive arms. Less central terms (protein refolding, erythrocyte differentiation, iron homeostasis) appear as secondary processes but do not outweigh the immune-focused signals. Overall, the cluster appears to reflect immune engagement and phagocytic processing.","confidence":"High","size":10,"edges":17,"triangles":3,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006911","count":9},{"id":"GO:0045087","count":9},{"id":"GO:0050871","count":9},{"id":"GO:0050853","count":9},{"id":"GO:0006910","count":9}]},{"hash":"1055047657586151760","title":"Unknown","description":"The top terms cover a wide range of unrelated processes (muscle migration, glycogen synthesis, inner ear development, motor learning, blood pressure regulation, dendritic spine morphogenesis, complement activation, cholesterol efflux, PDGF signaling regulation, and granulocyte differentiation), indicating no single coherent function or theme for the cluster. This suggests the proteins do not share a common, interpretable function category.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014912","count":3},{"id":"GO:0045725","count":3},{"id":"GO:0048839","count":3},{"id":"GO:0061743","count":3},{"id":"GO:0045776","count":3}]},{"hash":"2162137151365926353","title":"Motor Neuron Development and Axon Guidance","description":"This cluster centers on motor neuron development and connectivity, with GO terms for axonogenesis, spinal cord motor neuron fate specification, axon guidance, and lateral motor column neuron migration, along with cell-matrix adhesion that supports migration and pathfinding.","confidence":"High","size":10,"edges":31,"triangles":55,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0048936","count":5},{"id":"GO:1904948","count":5},{"id":"GO:0007160","count":5},{"id":"GO:0008045","count":5},{"id":"GO:0097477","count":5}]},{"hash":"1325614760485900171","title":"Neural development and cell adhesion","description":"The top GO terms are dominated by both homophilic/heterophilic cell-cell adhesion and nervous system/brain development and synapse assembly, with additional development-related terms (ossification, mesenchymal proliferation, hair patterning, lung morphogenesis). This suggests a cluster of proteins involved in neural development and cell\u2013cell communication during tissue morphogenesis, rather than a single tissue-specific pathway.","confidence":"High","size":10,"edges":34,"triangles":53,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":7},{"id":"GO:0007399","count":6},{"id":"GO:0007156","count":6},{"id":"GO:0043931","count":6},{"id":"GO:0051965","count":5}]},{"hash":"1967165540256055572","title":"Spliceosome-mediated mRNA processing","description":"The top GO terms cluster around mRNA splicing (cis and alternative via spliceosome), export from the nucleus, mRNA modification and regulation of poly(A) tail, plus translation initiation complex assembly, indicating a group of proteins involved in mRNA maturation and processing via spliceosome activity and related steps.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":5},{"id":"GO:0006406","count":4},{"id":"GO:0000380","count":4},{"id":"GO:0060211","count":4},{"id":"GO:0016556","count":4}]},{"hash":"680994812346594143","title":"TGF-\u03b2/BMP Signaling and Meristem Development","description":"The GO terms point to regulation and response of TGF-\u03b2/BMP pathways (negative BMP signaling, TGF-\u03b2 receptor signaling, cellular response to TGF-\u03b2), along with maintenance of meristem identity, suggesting a developmental signaling theme. Additional terms about nuclear export and MAPK-related processes fit a broader signaling-regulation context, reinforcing a label centered on TGF-\u03b2/BMP signaling in development.","confidence":"Medium","size":10,"edges":16,"triangles":10,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035970","count":3},{"id":"GO:0061191","count":3},{"id":"GO:0030514","count":3},{"id":"GO:0010074","count":3},{"id":"GO:0071560","count":3}]},{"hash":"1497419153788425129","title":"Cartilage ECM Remodeling and Skeletal Development","description":"This cluster is dominated by GO terms tied to cartilage and bone formation: collagen fibril organization, chondrocyte development, and skeletal system development, plus hyaluronan catabolic processes, all pointing to extracellular matrix remodeling during skeletal growth. A few terms related to neural development appear, suggesting broader developmental roles, but the strongest theme centers on cartilage/ECM and skeletal formation.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060134","count":2},{"id":"GO:0030199","count":2},{"id":"GO:1900625","count":2},{"id":"GO:0030214","count":2},{"id":"GO:0001501","count":2}]},{"hash":"1881108487762138635","title":"Developmental transcription and tissue differentiation","description":"The top GO terms cluster around DNA-templated transcription and multiple developmental processes (forebrain, neural tube, skin, skeletal system), plus chromatin regulation (histone H3 acetylation) and imprinting-related expression control, suggesting a developmental gene-regulation/differentiation theme. Some terms (defense response to Gram-positive bacterium, ER stress\u2013induced apoptosis) are less central but may reflect broader stress-regulated development networks. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0043588","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0030900","count":4},{"id":"GO:0070059","count":4}]},{"hash":"492366271174041082","title":"Spliceosome-driven mRNA splicing and processing","description":"The top terms are strongly centered on spliceosome-mediated splicing, including alternative splicing, splice site recognition, and regulation of splicing, with related mRNA processing steps (export, modification, poly(A) tail regulation) and translation reinitiation. The bone development term appears peripheral, so the core theme is mRNA splicing/processing. ","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":4},{"id":"GO:0060348","count":4},{"id":"GO:0006406","count":3},{"id":"GO:0000380","count":3},{"id":"GO:0060211","count":3}]},{"hash":"705046063589961812","title":"Rho GTPase signaling and cytoskeletal remodeling","description":"The top GO terms group around Rho-family GTPase signaling, small GTPase pathways, integrin activation, and lamellipodium assembly, all pointing to actin cytoskeleton remodeling and cell adhesion. While some terms touch on immune signaling and cardiac function, the dominant pattern is signaling that regulates the cytoskeleton via GTPases and adhesion machinery, making this a cohesive cytoskeletal remodeling cluster.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0033622","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0046580","count":3},{"id":"GO:0002344","count":3}]},{"hash":"1929258699619991355","title":"Ribosome Biogenesis and Translation","description":"This cluster centers on ribosome biology: cytoplasmic and mitochondrial translation, ribosome biogenesis, and rRNA processing/fidelity, indicating a coherent module of protein synthesis and ribosome assembly; the antibiotic response term likely reflects ribosome-targeting contexts rather than core function.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0046677","count":4},{"id":"GO:0070126","count":3},{"id":"GO:0002181","count":2},{"id":"GO:0042254","count":2}]},{"hash":"418933985630142381","title":"Unknown","description":"This cluster shows a highly diverse set of GO terms, including light detection for visual perception, tight junction assembly, gastrulation-related epiboly, locomotion and grooming behaviors, heart rate regulation, GDP biosynthesis, T cell receptor signaling, embryonic muscle contraction, and negative regulation of a MAP kinase cascade. The terms span sensory biology, development, behavior, immunity, metabolism, and signaling, with no single unifying function or process clearly tying the proteins together. None","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050908","count":2},{"id":"GO:0070830","count":1},{"id":"GO:0055113","count":1},{"id":"GO:0035641","count":1},{"id":"GO:0086091","count":1}]},{"hash":"397535177906868842","title":"Embryonic mesoderm and organ development","description":"These terms cluster around embryogenesis and mesoderm-derived organ formation (mesoderm development, heart-related EMT/endocardial cushion formation, left-right patterning, placenta and endocrine lineage differentiation, cartilage morphogenesis). One outlier term (ribosomal subunit export) is likely noise and does not change the overall developmental theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":10},{"id":"GO:0060536","count":10},{"id":"GO:0060972","count":10},{"id":"GO:0003323","count":10},{"id":"GO:0060707","count":10}]},{"hash":"484380624974004521","title":"Neuronal ion transport and synaptic signaling","description":"Most terms point to neuronal excitability: sodium/potassium ion transmembrane transport, membrane depolarization, excitatory postsynaptic potential, and transmission of nerve impulse, plus regulation of AMPA receptor activity. Some terms reference integrin signaling, tight junctions, and vasculogenesis, which may reflect broader context, but the dominant theme is ion channel\u2013driven neuronal communication.","confidence":"High","size":10,"edges":17,"triangles":8,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":7},{"id":"GO:0060079","count":7},{"id":"GO:0051899","count":7},{"id":"GO:0035725","count":7},{"id":"GO:2001046","count":5}]},{"hash":"204210506455044503","title":"Osteogenesis and Hedgehog Signaling","description":"The cluster centers on bone formation and development, with GO terms for bone trabecula formation and osteoblast differentiation, plus cell adhesion cues for tissue structuring. The presence of Hedgehog pathway regulation (Smoothened signaling) aligns with developmental and osteogenic processes, while inflammatory and complement terms may reflect remodeling contexts accompanying bone development. Overall, the dominant theme is bone formation and multicellular development guided by adhesion and signaling cues.","confidence":"High","size":10,"edges":28,"triangles":34,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007157","count":7},{"id":"GO:0007160","count":6},{"id":"GO:0045880","count":6},{"id":"GO:0060346","count":6},{"id":"GO:2000270","count":5}]},{"hash":"1955435870794627329","title":"Immune Activation and Cytokine Signaling","description":"The top GO terms cluster around increased production of cytokines and chemokines (TNF, IL-6, MCP-1), T cell proliferation/migration, macrophage inflammatory differentiation, and defense against viral infection, indicating a coordinated immune activation/inflammatory signaling program. A few terms (e.g., blastoderm segmentation) appear unrelated and may be noise.","confidence":"High","size":10,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0090197","count":2},{"id":"GO:0071639","count":2},{"id":"GO:0042102","count":2},{"id":"GO:0010742","count":1},{"id":"GO:0002230","count":1}]},{"hash":"213710224284475364","title":"Ubiquitin-Proteasome Proteostasis and DNA Repair","description":"The dominant signals are ubiquitin-mediated proteolysis and proteostasis (free ubiquitin chain polymerization, ERAD pathway, proteasome localization) with DNA repair and apoptotic processes, suggesting a cluster tied to protein quality control and DNA damage response; some terms appear obsolete, likely noise.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0045739","count":1},{"id":"GO:0010994","count":1},{"id":"GO:0007288","count":1}]},{"hash":"1755609374054974835","title":"Embryonic development and organ morphogenesis","description":"The proteins are associated with a range of developmental processes, including placenta and embryonic development, branching morphogenesis of vessels, EMT during heart/endocardial cushion formation, cartilage morphogenesis, endocrine system development, and left-right patterning. This suggests a broad developmental/programmatic role across tissues rather than a single tissue-specific function, justifying a label focused on embryonic development and organ morphogenesis.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:1902042","count":2},{"id":"GO:0030307","count":2},{"id":"GO:0001569","count":2},{"id":"GO:0003323","count":2}]},{"hash":"1583204083294630488","title":"Lipid Transport and Innate Immunity","description":"The cluster centers on lipid transport and lipoprotein metabolism, with concurrent signals of innate immune activation (innate immune response, interferon-beta signaling, defense against Gram-negative bacteria and protozoa) and endothelial activation. A few bacterial biosynthesis terms are present but secondary to the lipid-immune theme.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006869","count":2},{"id":"GO:0042118","count":2},{"id":"GO:0042157","count":2},{"id":"GO:0050829","count":1},{"id":"GO:0045087","count":1}]},{"hash":"169226661176549759","title":"TLR-driven innate immunity and dendritic cell activation","description":"The top terms point to innate immune sensing and signaling via Toll-like receptors (MyD88-dependent pathway, LPS detection) and dendritic cell cytokine production, complemented by general receptor tyrosine kinase signaling. Additional terms hint at inflammation-associated vascular remodeling and autophagy, suggesting a cohesive theme of TLR-mediated immune activation with related cellular stress responses.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002730","count":6},{"id":"GO:0002755","count":6},{"id":"GO:0007169","count":6},{"id":"GO:0007413","count":6},{"id":"GO:0036303","count":6}]},{"hash":"603287535824151291","title":"Neural development and synaptic plasticity","description":"The top GO terms cluster around neural development processes such as axonogenesis, regulation of synaptic plasticity, and calcium channel activity, with supportive signals from astrocyte activation and EMT-like development. This points to proteins involved in neuron-glia signaling and neuronal maturation rather than generic transcriptional regulation, making a neural development/plasticity theme a fitting label.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007613","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0008360","count":2},{"id":"GO:0001837","count":2},{"id":"GO:0048168","count":2}]},{"hash":"796742081103479675","title":"Developmental vesicle trafficking and TORC1 signaling","description":"The top GO terms point to ER-Golgi vesicle transport and retrograde transport, GTPase activity regulation, and signaling (TORC1), with overarching developmental contexts (multicellular development, skeletal system development) and mRNA transport. This suggests a cohesive theme: proteins coordinating vesicle trafficking and growth-related signaling during development, rather than a random mix of unrelated processes.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006890","count":3}]},{"hash":"540240618649395339","title":"RNA methylation and RNA capping","description":"The top GO terms are dominated by methylation-related processes across nucleic acids and RNA processing (tRNA methylation, rRNA methylation, 7-methylguanosine capping, 2-methylguanosine metabolism, and DNA methylation references), with protein methylation also present. A couple of unrelated terms appear but do not define the cluster; overall, the shared theme is methylation-based modification of RNA and related substrates.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032435","count":2},{"id":"GO:0006479","count":2},{"id":"GO:0080180","count":2},{"id":"GO:0032775","count":2},{"id":"GO:0030488","count":2}]},{"hash":"1839876010461674956","title":"Protein acetylation pathways and polyamine metabolism","description":"This cluster is dominated by GO terms for various acetylation processes (N-terminal acetylation, peptidyl-lysine N6-acetylation, N-terminal propionylation, spermine and putrescine acetylation) and related polyamine turnover (spermine catabolic process, putrescine acetylation). Additional terms like mycothiol biosynthesis and glucosamine metabolism frame a broader metabolic context. The lone leaf-formation regulation term is likely an annotation outlier. Overall, the shared theme is acetylation-linked protein modifications and polyamine metabolism. ","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0046208","count":10},{"id":"GO:0017198","count":10},{"id":"GO:0018003","count":10},{"id":"GO:0010125","count":10},{"id":"GO:0032920","count":10}]},{"hash":"165298463033450273","title":"Mitochondrial Transport and Fission","description":"The top GO terms cluster around mitochondrial activities: multiple transmembrane transport roles for metabolites and cofactors (citrate, ornithine, pyridoxal phosphate, CoA, manganese) and a term for mitochondrial membrane fission. This combination strongly suggests proteins functioning as mitochondrial carriers or regulators of mitochondrial dynamics, making the label Mitochondrial Transport and Fission a concise reflection of the shared theme. Some terms pertain to broader metabolic regulation (e.g., insulin secretion), but the dominant signal is mitochondrial transport/dynamics.","confidence":"High","size":10,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060546","count":7},{"id":"GO:0006828","count":6},{"id":"GO:0031921","count":6},{"id":"GO:0006843","count":6},{"id":"GO:0090149","count":6}]},{"hash":"470447138698162700","title":"Cardiovascular GPCR-Calcium Signaling","description":"The terms point to GPCR signaling and calcium release into the cytosol, with several entries describing heart contraction regulation and vascular smooth muscle contraction. This suggests a shared function of GPCR-triggered calcium signaling governing cardiac and vascular muscle activity. While a term like dendritic cell chemotaxis highlights GPCR roles in other cells, it does not contradict the core theme, so this label is representative.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":6},{"id":"GO:0033861","count":4},{"id":"GO:0031649","count":4},{"id":"GO:2000420","count":4},{"id":"GO:0001997","count":4}]},{"hash":"1827690773720743433","title":"Neuronal synaptic signaling and plasticity","description":"Top GO terms cluster around neuronal synaptic activity and plasticity (long-term depression/potentiation, excitatory postsynaptic potential, receptor clustering, and receptor signaling). Additional terms reflect cellular processes that support synapse formation and function (trafficking between ER and Golgi, centrosome localization, tight junction assembly) and organismal behaviors linked to neural circuits (social and locomotor exploration). Together they suggest a cohesive theme of neuronal communication and plasticity.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":3},{"id":"GO:0051660","count":3},{"id":"GO:1900273","count":2},{"id":"GO:0043113","count":2},{"id":"GO:0060079","count":2}]},{"hash":"1550343957553616537","title":"Amino acid neurotransmitter transport and signaling","description":"The top GO terms cluster around transport and handling of amino acid neurotransmitters (taurine transport, proline transport, glycine secretion, glycinergic transmission, serotonin uptake) and monoamine turnover (dopamine catabolic process), suggesting a shared role in neurotransmitter transport and synaptic signaling in the nervous system. Developmental terms for brain structures and glial growth are present but secondary to the core theme of neural amino acid signaling. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015734","count":6},{"id":"GO:0060012","count":6},{"id":"GO:0021984","count":6},{"id":"GO:0021794","count":6},{"id":"GO:0042066","count":6}]},{"hash":"523906145686980918","title":"Unknown","description":"The GO terms are highly diverse and do not point to a single shared function: several terms relate to vertebrate development (lung mesenchyme, Schwann cell development, valve morphogenesis) and stress responses (MAPK cascade, apoptotic process, response to toxic substance), but others are plant-specific (abscisic acid signaling) or otherwise unrelated (vitamin D3 metabolism). This mixture suggests no coherent, unique function characterizes the cluster.","confidence":"","size":9,"edges":13,"triangles":8,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070640","count":9},{"id":"GO:0072709","count":9},{"id":"GO:0000196","count":9},{"id":"GO:0060484","count":9},{"id":"GO:0006915","count":9}]},{"hash":"325461535130720489","title":"Neural development and glutamatergic signaling","description":"Top GO terms center on neural development and synaptic function (retinal ganglion cell axon guidance; NMDA receptor clustering; positive regulation of glutamatergic synaptic transmission), with additional transcriptional regulation signals. This suggests the proteins collectively participate in neural wiring and synapse modulation rather than a single metabolic pathway, with some immune/vascular-related terms likely representing broader regulatory roles or annotation noise.","confidence":"High","size":9,"edges":31,"triangles":54,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":3},{"id":"GO:0009952","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0045348","count":2},{"id":"GO:0035470","count":2}]},{"hash":"2044847946728695344","title":"Spliceosome-driven mRNA processing and translation regulation","description":"This cluster's terms cluster around mRNA splicing via the spliceosome, mRNA export and stability regulation, and translation initiation, plus regulatory ncRNA-mediated gene silencing, indicating a shared theme of RNA processing and translational control. The presence of brain development hints a possible neuronal context but core signal is RNA splicing/processing and translation regulation.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":5},{"id":"GO:0000398","count":4},{"id":"GO:0010610","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0048026","count":4}]},{"hash":"684736964762142322","title":"Chromatin Organization & Histone Modification","description":"The top GO terms are all centered on chromatin biology: nucleosome assembly and heterochromatin organization, histone modifications (H3K27 and H3K4 methylation), and establishment of protein localization to chromatin. This strongly suggests a cluster function in chromatin architecture and epigenetic regulation.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0097298","count":8},{"id":"GO:0016584","count":8},{"id":"GO:0070828","count":8},{"id":"GO:0098532","count":8},{"id":"GO:0071169","count":8}]},{"hash":"1473848329405110109","title":"Plasma Membrane Solute Transporters","description":"This cluster is dominated by GO terms for transmembrane transport of diverse solutes, including nitrate, sugars (glucose, trehalose, fructose-related), organic anions, potassium ions, and xenobiotics, suggesting a group of plasma membrane transporter proteins with broad substrate specificity.","confidence":"High","size":9,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0071332","count":3},{"id":"GO:0043252","count":3},{"id":"GO:0015706","count":3}]},{"hash":"1810045810752893171","title":"Mitotic/meiotic regulation and nuclear transport","description":"These proteins cluster around cell division processes, with strong signals for meiosis and mitosis (meiotic spindle elongation, mitotic sister chromatid separation, nuclear membrane reassembly) as well as related nuclear transport and regulatory signaling (mRNA transport, ribosomal protein import into nucleus, GTPase/kinase regulation, desumoylation). The common theme is coordination of chromosome segregation and nuclear dynamics during cell division.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006610","count":3},{"id":"GO:1903538","count":3},{"id":"GO:0051028","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0033674","count":3}]},{"hash":"171714254911130774","title":"Unknown","description":"The GO terms in this cluster span memory, various signaling cascades, cytoskeleton/EMT, plant hormone signaling, and bioluminescence, with no single shared function or pathway evident. The lack of a cohesive theme suggests no reliable label other than Unknown.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007614","count":4},{"id":"GO:0051533","count":4},{"id":"GO:0008360","count":4},{"id":"GO:0008218","count":4},{"id":"GO:0007616","count":4}]},{"hash":"756195442981521706","title":"Cardiac Muscle Contraction and Sarcomere Organization","description":"The dominant GO terms center on cardiac muscle contraction, heart rate regulation by epinephrine, and sarcomere organization/assembly, indicating involvement in cardiac contractile machinery; a few outlier terms (visual perception, phototransduction, spicule insertion) are less related and likely reflect multi-function annotations, but do not override the core muscle/sarcomere theme.","confidence":"High","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060048","count":8},{"id":"GO:0003065","count":7},{"id":"GO:1904753","count":7},{"id":"GO:0034609","count":7},{"id":"GO:1904706","count":7}]},{"hash":"896445883757037965","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":17,"triangles":11,"max_degree":6,"top_function":"cytoskeleton organization","top_go_terms":[{"id":"GO:0051491","count":4},{"id":"GO:0005975","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0019262","count":4},{"id":"GO:0006209","count":4}]},{"hash":"424091663855660321","title":"Mitochondrial Transport and Membrane Regulation","description":"The cluster is dominated by GO terms for transporting various metabolites across mitochondrial membranes (heme, phosphate, nucleotides, glycine, thiamine pyrophosphate, ornithine) and for regulating mitochondrial membrane permeability and apoptotic changes, pointing to a coherent theme of mitochondrial metabolite transport and membrane dynamics.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015886","count":7},{"id":"GO:0035435","count":7},{"id":"GO:0000066","count":5},{"id":"GO:0008637","count":5},{"id":"GO:0030974","count":5}]},{"hash":"104846357270792830","title":"Nuclear mRNA Splicing and Processing","description":"The cluster is dominated by GO terms for spliceosome-dependent mRNA splicing, alternative splicing regulation, mRNA polyadenylation/export, and mRNA modification, pointing to a nuclear RNA processing module centered on mRNA maturation and trafficking.","confidence":"High","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":4},{"id":"GO:0006378","count":4},{"id":"GO:0006406","count":3},{"id":"GO:0000380","count":3},{"id":"GO:0060211","count":3}]},{"hash":"1141070500140327188","title":"Platelet formation and coagulation","description":"The top terms are dominated by blood coagulation, megakaryocyte development, and platelet formation, with notable integrin-mediated signaling. This combination strongly points to platelet biogenesis and hemostasis as the cluster\u2019s core function. The presence of innate/adaptive immune terms and enamel mineralization is likely due to broader signaling connections rather than indicating a distinct, separate function.","confidence":"High","size":9,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":4},{"id":"GO:0035855","count":4},{"id":"GO:0030220","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0070166","count":2}]},{"hash":"1881906011374979233","title":"Cell Cycle and Vesicle Trafficking","description":"The top terms show a mix of nuclear/cell division functions (DNA-templated transcription, CENP-A chromatin assembly, cell division, microtubule severing) with vesicle transport between the ER and Golgi (anterograde and retrograde pathways). This suggests a theme of coordinated mitotic/chromatin processes alongside intracellular trafficking, potentially linked by GTPase regulation. Some terms (tRNA wobble modification, cobalamin biosynthesis) are outliers, likely noise, but the core signal points to cell-cycle machinery and vesicle movement.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0009236","count":5},{"id":"GO:0002098","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0030433","count":4}]},{"hash":"734106475646044632","title":"Neuronal vesicle trafficking and dendrite development","description":"Based on the top GO terms, the cluster centers on vesicle transport between ER, Golgi, and endosomes, exocytosis docking, and targeting proteins to the plasma membrane, with supports from dendrite development and bipolar cell growth terms. This suggests a cohesive role in neuronal vesicle trafficking and morphogenesis, rather than unrelated stress responses.","confidence":"High","size":9,"edges":9,"triangles":0,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":5},{"id":"GO:0034498","count":5},{"id":"GO:0016358","count":4},{"id":"GO:0035690","count":4},{"id":"GO:1903078","count":3}]},{"hash":"1914272570776133329","title":"NO- and Ca2+-responsive signaling with TGF-\u03b2/BMP regulation","description":"The cluster centers on cellular responses to nitric oxide and calcium, xenobiotic stimuli, and exhibits regulatory connections to the TGF-\u03b2/BMP signaling pathways, including negative regulation of related components. Coupled with proteolysis and amino acid\u2013related metabolic processes (glycine betaine and homocysteine), this suggests a coordinated stress-response and signaling regulation network rather than a single straightforward function.","confidence":"Medium","size":9,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071732","count":3},{"id":"GO:0031457","count":3},{"id":"GO:0050667","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0071277","count":3}]},{"hash":"2198703251538792737","title":"Ubiquitin-mediated protein turnover and signaling","description":"This cluster centers on ubiquitination-related processes (protein autoubiquitination, ubiquitin-dependent protein catabolic process, actin ubiquitination) and autophagy, pointing to proteostasis control via the ubiquitin-proteasome system and autophagic pathways. Additional GO terms suggest related signaling roles (MHC I biosynthesis, IGF receptor signaling, miRNA silencing, retinoic acid signaling), but the dominant theme is ubiquitin-driven protein turnover and turnover-linked signaling. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1903762","count":5},{"id":"GO:1901253","count":5},{"id":"GO:0051865","count":5},{"id":"GO:0042787","count":4},{"id":"GO:0043569","count":4}]},{"hash":"2041262330477182597","title":"Osteoclast Podosome Formation and Actin Remodeling","description":"This cluster is dominated by osteoclast-related processes (osteoclast differentiation, podosome assembly) and actin cytoskeleton organization at the plasma membrane, pointing to cytoskeletal remodeling essential for osteoclast function. While some terms touch on skin or lens development or signaling, the strongest, recurring theme is podosome-mediated actin remodeling in osteoclasts.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0030866","count":4},{"id":"GO:0090002","count":4},{"id":"GO:0030316","count":4},{"id":"GO:0071803","count":4},{"id":"GO:0001845","count":3}]},{"hash":"288776508774559596","title":"Embryonic placental development and morphogenesis","description":"Most terms describe embryonic development and tissue patterning, especially placental/extraembryonic lineages (type B pancreatic cell development, trophoblast giant cell differentiation, EMT in endocardial cushion formation) and general morphogenesis (cartilage morphogenesis, left-right pattern formation). A few RNA-processing terms appear as background housekeeping, but the dominant signal is embryonic development and placental morphogenesis. Hence the label","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":7},{"id":"GO:0060707","count":7},{"id":"GO:0003198","count":7},{"id":"GO:0060806","count":7},{"id":"GO:0035270","count":7}]},{"hash":"1469187701918134697","title":"Plant secondary metabolism and hormone biosynthesis","description":"Among the top GO terms are oxylipin biosynthetic process, ent-kaurene oxidation to kaurenoic acid (key steps in gibberellin diterpene biosynthesis), isoquinoline alkaloid metabolic process, alkaloid catabolic process, and retinoic acid biosynthesis. These strongly point to plant-specific biosynthetic pathways for defense compounds and growth hormones. Some terms like response to vitamin D or copper ion response are less clearly related and may reflect cross-species annotations. Overall the cluster appears centered on plant specialized metabolism and hormone biosynthesis.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0060137","count":2},{"id":"GO:0009822","count":2},{"id":"GO:0031408","count":2},{"id":"GO:0010241","count":2},{"id":"GO:0033280","count":2}]},{"hash":"1500694382778138525","title":"T cell immune signaling and cytokine production","description":"The cluster is dominated by immune-related GO terms involving T cells (T cell apoptotic process, T cell cytokine production, innate immune response-activating signaling pathway), pointing to immune signaling activity. Some terms about protein transport and ER lumen retention suggest a connection to secretory pathways, which can accompany cytokine production; these terms may reflect shared cellular logistics rather than a separate pathway. Overall, the label captures the prominent immune signaling theme with minor transport-related context.","confidence":"Medium","size":9,"edges":11,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0006621","count":2},{"id":"GO:0015031","count":2},{"id":"GO:0070231","count":2},{"id":"GO:0010204","count":2}]},{"hash":"888308181787388312","title":"Cartilage ECM remodeling and enamel biomineralization","description":"Top GO terms point to cartilage development (chondrocyte proliferation) and ECM turnover (collagen catabolic process, extracellular matrix disassembly) along with mineralized tissue formation (biomineral tissue development, amelogenesis). This suggests a cluster of proteins involved in remodeling the extracellular matrix during cartilage/bone and enamel formation, with supporting immune/inflammatory signals as secondary context.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035988","count":3},{"id":"GO:0030574","count":2},{"id":"GO:0044130","count":2},{"id":"GO:0031214","count":2},{"id":"GO:0006953","count":2}]},{"hash":"572768000677227674","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048105","count":2},{"id":"GO:0072137","count":2},{"id":"GO:0060901","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0060490","count":2}]},{"hash":"2177548879056498607","title":"Neural development and synapse formation","description":"This cluster is dominated by GO terms tied to nervous system development, synapse assembly, and axon extension, suggesting a cohesive role in neural development and connectivity. Other terms point to broader signaling pathways but do not override the neural theme.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0045773","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0008286","count":2}]},{"hash":"136277443923260615","title":"Neddylation Regulation and Ubiquitin-like Modification","description":"The cluster centers on regulation of protein neddylation and ubiquitin-like modification, including positive and negative control of neddylation and related ubiquitin-protein transferase activity, with links to protein turnover and intracellular transport; the gamma radiation and UV-C responses hint at a DNA-damage\u2013response context.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010332","count":2},{"id":"GO:0045116","count":2},{"id":"GO:2000436","count":2},{"id":"GO:0010225","count":2},{"id":"GO:0051443","count":2}]},{"hash":"1639981770078431875","title":"AMPA receptor\u2013mediated striatal synaptic plasticity","description":"The top GO terms point to glutamatergic synaptic modulation and plasticity in striatal neurons (AMPA receptor clustering, AMPA receptor activity, long-term synaptic plasticity/depression, and striatal medium spiny neuron differentiation). While bone development and innate immune response appear, the dominant theme is AMPA receptor\u2013driven synaptic changes in the striatum, suggesting a functional cluster of neuronal plasticity and glutamatergic signaling.","confidence":"High","size":9,"edges":10,"triangles":1,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060348","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0006915","count":8},{"id":"GO:0097113","count":8},{"id":"GO:1900044","count":8}]},{"hash":"1105119158323186003","title":"GPCR-Regulated Cardiovascular Signaling","description":"The top GO terms point to regulation of GPCR signaling, including heart contraction and vascular smooth muscle contraction, as well as downstream pathways like adenylate cyclase and GTPase activity, all centered on GPCR-mediated signaling. Additional terms involving dopamine secretion and dendritic cell chemotaxis suggest broader neural-immune regulatory roles, but the shared theme remains GPCR-driven signaling affecting cardiovascular function.","confidence":"Medium","size":9,"edges":32,"triangles":60,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":9},{"id":"GO:0031649","count":9},{"id":"GO:2000420","count":9},{"id":"GO:0001997","count":9},{"id":"GO:0045745","count":9}]},{"hash":"1019938312757005194","title":"B cell activation and antibody diversification","description":"The top terms point to immune-related functions, especially innate immune response and interferon signaling, together with B cell\u2013specific processes like somatic hypermutation and isotype switching, indicating antibody diversification and adaptive immune activation. A few development-related terms (bone development, atrial septum morphogenesis) are present but appear secondary and less representative of the cluster\u2019s core function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":2},{"id":"GO:0060335","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0010452","count":1},{"id":"GO:0043046","count":1}]},{"hash":"377749802756734141","title":"Oxidative and inflammatory stress response","description":"The top GO terms are dominated by cellular responses to oxidative stress (hydrogen peroxide) and inflammatory stimuli (TNF, IL-1, LPS, virus), suggesting the proteins cluster around innate stress signaling and immune activation. Some metabolic and developmental terms appear but are less represented, so the core theme centers on oxidative/inflammatory responses.","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":4},{"id":"GO:0071356","count":4},{"id":"GO:0071347","count":4},{"id":"GO:0042632","count":3},{"id":"GO:0071222","count":3}]},{"hash":"155533770690672269","title":"Golgi-ER and endosomal vesicle trafficking","description":"The top GO terms are dominated by vesicle transport involving the Golgi, ER, endosomes, and vacuoles (Golgi-ER retrograde transport, ER-to-Golgi transport, endocytosis, Golgi-to-vacuole transport, endosome-to-Golgi transport), with Golgi localization repeatedly mentioned. This points to a cohesive function in vesicle trafficking centered on Golgi and related organelles, despite some noise from unrelated terms like synaptic vesicle budding and locomotion. ","confidence":"High","size":9,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0006897","count":3},{"id":"GO:0006623","count":3},{"id":"GO:0042147","count":3}]},{"hash":"813040354711298994","title":"Ciliary photoreceptor proteins and steroid signaling components","description":"This cluster is driven by GO terms for cilium assembly and photoreceptor outer segment localization, with additional signals for steroid hormone receptor complex assembly and prostate/male reproductive development, suggesting a group of proteins involved in ciliary/retinal functions that intersect with hormone signaling. Some terms (interferon response, gluconeogenesis regulation) are less central to the core theme but may reflect broader regulatory roles.","confidence":"Medium","size":9,"edges":9,"triangles":0,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046661","count":5},{"id":"GO:1903546","count":5},{"id":"GO:0071357","count":5},{"id":"GO:0030850","count":5},{"id":"GO:0045842","count":5}]},{"hash":"1942362136664729832","title":"Dopaminergic Neurotransmission and Vesicle Transport","description":"The cluster is enriched with dopamine-related processes (dopamine biosynthetic process, regulation of dopamine secretion) plus synaptic vesicle transport and neuronal signaling terms, pointing to a coherent theme of dopaminergic neurotransmission and vesicle cycling; energy-related terms like mitochondrial ATP synthesis support this vesicle trafficking activity.","confidence":"High","size":9,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":4},{"id":"GO:0071902","count":4},{"id":"GO:0008344","count":4},{"id":"GO:0042775","count":3},{"id":"GO:0045920","count":3}]},{"hash":"1981216343417928255","title":"Adaptive immune cell development and cytokine signaling","description":"The top GO terms cluster around immune system development and cytokine responses (B cell affinity maturation, NK T cell differentiation, hemopoiesis, IL-4 production, cellular responses to IL-7), with cell migration and cytokine-related stimuli supporting a cohesive theme of immune cell maturation and signaling. Some terms like insulin signaling and heart development are less central and may reflect broader pleiotropy or noise, but they do not outweigh the immune-focused terms. ","confidence":"Medium","size":9,"edges":6,"triangles":0,"max_degree":4,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0016477","count":5},{"id":"GO:0002344","count":5},{"id":"GO:0008286","count":5},{"id":"GO:0032633","count":5},{"id":"GO:0007507","count":5}]},{"hash":"491509306851431948","title":"Inflammation and angiogenesis signaling","description":"This cluster\u2019s GO terms center on positive regulation of immune/cytokine signaling (chemokine production, mast cell chemotaxis) and signaling pathways (JNK cascade) that drive inflammatory responses, as well as processes involved in tissue remodeling like angiogenesis and smooth muscle proliferation. Even with obsolete terms, the shared theme points to inflammatory signaling and vascular remodeling activities.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":3},{"id":"GO:0048661","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0001798","count":2},{"id":"GO:0035584","count":2}]},{"hash":"852592954438570858","title":"Secretory Pathway Regulation","description":"The top terms are dominated by protein transport and secretion, notably Golgi to plasma membrane transport and positive regulation of protein secretion, which strongly points to vesicle trafficking through the secretory pathway. Chromatin-related terms appear less consistently, suggesting they\u2019re peripheral to the main theme.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015031","count":2},{"id":"GO:0006893","count":2},{"id":"GO:0050714","count":2},{"id":"GO:0043085","count":1},{"id":"GO:0007117","count":1}]},{"hash":"2028864119772922518","title":"Cholesterol and isoprenoid biosynthesis","description":"This cluster is dominated by sterol and isoprenoid biosynthetic processes (cholesterol biosynthesis, mevalonate pathway, IPP biosynthesis) with supporting lipid-related metabolism signals, including pantothenate biosynthesis feeding CoA and energy/redox context (NADPH regeneration, electron transport) necessary for biosynthesis. The convergence on lipid/sterol production suggests a coherent lipid metabolism theme.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015940","count":2},{"id":"GO:0006740","count":2},{"id":"GO:0032364","count":1},{"id":"GO:0016226","count":1},{"id":"GO:0042773","count":1}]},{"hash":"2001249318361725665","title":"GPCR Signaling in Neuroendocrine Regulation","description":"GPCR signaling terms dominate the list (positive regulation of GPCR signaling, serotonin receptor signaling, adenylate cyclase inhibition), with links to neuroendocrine outputs (dopamine/serotonin signaling) and cardiovascular effects (epinephrine-norepinephrine\u2013regulated heart contraction, smooth muscle contraction). The cluster seems centered on GPCR-mediated regulation across neural, hormonal, and vascular processes, justifying a label focused on GPCR signaling in neuroendocrine regulation. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":9},{"id":"GO:0031649","count":9},{"id":"GO:2000420","count":9},{"id":"GO:0001997","count":9},{"id":"GO:0045745","count":9}]},{"hash":"513304842166134141","title":"Methylation and metabolite biosynthesis","description":"The cluster\u2019s top GO terms center on two themes: methylation events (N-terminal peptidyl-glycine methylation and rRNA methylation) and biosynthesis of diverse metabolites (biotin, ubiquinone, vitamin E, antibiotic, juvenile hormone), with an odd inclusion of nodulation and selenium metabolism. This suggests a cohesive function around enzymatic modification and production of small molecules, tying the proteins to methylation-linked and metabolite biosynthesis pathways.","confidence":"Medium","size":9,"edges":18,"triangles":14,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0018013","count":5},{"id":"GO:0031167","count":5},{"id":"GO:0001887","count":5},{"id":"GO:0009102","count":5},{"id":"GO:0006744","count":5}]},{"hash":"1032217858892556161","title":"ECM remodeling and cell adhesion","description":"The terms cluster around extracellular matrix regulation (negative ECM assembly, metallopeptidase activity), diverse cell-matrix and cell\u2013cell adhesion (adhesion terms, chondrocyte morphogenesis), and wound-related processes (blood coagulation, complement activation), indicating a common theme of matrix remodeling and adhesion in tissue development and repair.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0043588","count":5},{"id":"GO:0034113","count":5},{"id":"GO:0007596","count":5},{"id":"GO:0006956","count":5},{"id":"GO:0003429","count":5}]},{"hash":"1585038926612789421","title":"Integrated stress response and translation regulation","description":"The GO terms point to cellular stress responses (acidic pH, UV-C, ER stress with eIF2\u03b1 phosphorylation, GCN2 signaling, HIF-1\u03b1) alongside control of protein synthesis and processing (cytoplasmic translation, protein sumoylation regulation, nuclear import). Together they suggest a theme of how cells balance signaling and translation under stress, rather than a single pathway. Some terms (like AR signaling regulation) are more peripheral but can be linked to stress-responsive regulation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060765","count":2},{"id":"GO:0000060","count":2},{"id":"GO:0002181","count":1},{"id":"GO:1990451","count":1},{"id":"GO:0033235","count":1}]},{"hash":"554757223523482086","title":"DNA replication and oxidative stress response","description":"The cluster centers on DNA replication and cell cycle processes (GO:0006260, GO:0051301) while also showing strong links to oxidative stress and proteostasis (GO:0034599, GO:0071218). The presence of a transcription elongation regulation term (GO:0032968) suggests coordinated transcriptional control during replication and stress. Overall, these proteins likely participate in DNA replication/cell cycle with oxidative stress response pathways.","confidence":"Medium","size":9,"edges":10,"triangles":2,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0034599","count":3},{"id":"GO:0032968","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0051260","count":3}]},{"hash":"981810095893458161","title":"Central carbon and amino-acid metabolism","description":"These proteins show enrichment for several core metabolic processes, including serine biosynthesis, valine catabolism, malate and pyruvate metabolism, and menaquinone biosynthesis, with a note on NADP metabolism regulation. Together these suggest a cluster centered on metabolic pathways rather than signaling or structural roles.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006564","count":2},{"id":"GO:0006574","count":2},{"id":"GO:0046177","count":2},{"id":"GO:0009234","count":2}]},{"hash":"469102434298594350","title":"Regulation of Physiological Homeostasis","description":"This cluster is characterized by multiple GO terms related to regulation of essential physiological processes\u2014appetite, heart rate, blood pressure, and renal function\u2014suggesting a theme of systemic homeostatic control. While a few terms (like glycosylation and limb development) are broader or orthogonal, the predominance of regulatory terms across metabolic and cardiovascular/renal functions supports labeling the cluster as centered on physiological homeostasis.","confidence":"Medium","size":9,"edges":11,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032099","count":1},{"id":"GO:0044539","count":1},{"id":"GO:0051930","count":1},{"id":"GO:0003084","count":1},{"id":"GO:0035814","count":1}]},{"hash":"8121453852750106","title":"Cell Adhesion and Tissue Morphogenesis","description":"The top GO terms point to cell-cell adhesion (homophilic/heterophilic) and several tissue development processes (bone remodeling, ossification, basement membrane development, and morphogenesis of nipple, retina, and lung connective tissue), suggesting proteins that mediate adhesion to drive tissue formation and ECM remodeling. An outlier term for complement activation may reflect annotation noise rather than a core cluster theme.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0060658","count":2}]},{"hash":"1647192921324542107","title":"Nuclear mRNA Processing and Splicing","description":"This cluster is dominated by GO terms tied to nuclear mRNA maturation\u2014polyadenylation, export, and especially spliceosome-mediated splicing and its regulation\u2014along with related mRNA modification steps. This pattern suggests a cohesive function in RNA processing rather than other cellular roles, justifying a label centered on mRNA processing and splicing.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":6},{"id":"GO:0006406","count":3},{"id":"GO:0000380","count":3},{"id":"GO:0060211","count":3},{"id":"GO:0045292","count":3}]},{"hash":"1527373451093962945","title":"Zinc Ion Transport and Homeostasis","description":"The cluster is driven by GO terms for zinc import across membranes, intracellular zinc ion homeostasis, detoxification, and response to zinc starvation, indicating proteins that participate in zinc uptake and regulation. A couple of outliers (limb development, cadmium transport, arginine import) are peripheral and do not define the core function.","confidence":"High","size":9,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0060173","count":1},{"id":"GO:1903615","count":1},{"id":"GO:0006830","count":1},{"id":"GO:0006831","count":1},{"id":"GO:0006882","count":1}]},{"hash":"1177750736753411699","title":"Embryonic patterning and morphogenesis","description":"The terms cluster around embryonic development and tissue morphogenesis (EMT in endocardial cushion formation, cartilage morphogenesis, left-right patterning, pancreatic and endocrine development, trophoblast differentiation), with some RNA processing/regulatory terms as ancillary.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":7},{"id":"GO:0060536","count":7},{"id":"GO:0060972","count":7},{"id":"GO:0003323","count":7},{"id":"GO:0000055","count":7}]},{"hash":"1411923141843665525","title":"Unknown","description":"The Top Terms are diverse and fragmented: while there is some emphasis on redox homeostasis and tRNA modification, many other terms (spinal cord development, epithelial differentiation, pseudohyphal growth, glycerol metabolism, protein urmylation) point to unrelated processes. There is no single coherent function tying the cluster together, so a clear label is not identifiable. ","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0070329","count":1},{"id":"GO:0021510","count":1},{"id":"GO:0006777","count":1},{"id":"GO:0035335","count":1}]},{"hash":"2275923482254262414","title":"Cardiovascular GPCR Signaling","description":"This cluster\u2019s terms cluster around G protein-coupled receptor signaling with clear links to cardiovascular regulation: positive regulation of GPCR signaling, epinephrine/norepinephrine-modulated heart contraction, vascular smooth muscle contraction, and serotonin receptor signaling influencing adenylate cyclase. While there are a few immune-related terms (e.g., dendritic cell chemotaxis, eosinophil regulation), the dominant theme is GPCR-driven control of heart and vascular function, suggesting a coherent cardiovascular signaling role. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":9},{"id":"GO:0031649","count":9},{"id":"GO:2000420","count":9},{"id":"GO:0001997","count":9},{"id":"GO:0045745","count":9}]},{"hash":"1286915331726375369","title":"Calcium-Dependent Vesicle Exocytosis","description":"The cluster centers on secretory processes: insulin and dopamine secretion, egg activation, lysosome exocytosis, and vesicle fusion, all linked by calcium signaling via IP3. While a few terms (e.g., ABA signaling, glucose transport) are peripheral, the dominant theme is calcium-driven vesicle trafficking and exocytosis.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032024","count":3},{"id":"GO:0008286","count":2},{"id":"GO:0015758","count":2},{"id":"GO:0007343","count":2},{"id":"GO:1990927","count":2}]},{"hash":"699885324167774296","title":"Developmental signaling and morphogenesis","description":"These proteins show a pattern across multiple developmental processes and tissues: heart development, angiogenesis, visual system development, Schwann cell development, axonogenesis, and myoblast fusion, all pointing to morphogenesis and tissue patterning. They are linked by signaling and regulation of cell behavior (e.g., peptidyl-threonine phosphorylation) and cell-cycle transitions, suggesting a shared role in coordinating development rather than a single pathway. The presence of a plant ABA signaling term and polarity site selection adds some diversity, but the overarching theme remains developmental signaling across tissues.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0009738","count":8},{"id":"GO:0014044","count":8},{"id":"GO:0007409","count":8},{"id":"GO:0007520","count":8},{"id":"GO:0010800","count":8}]},{"hash":"1533847377871318165","title":"Multi-tissue Development and Differentiation","description":"The GO terms converge on developmental differentiation across multiple tissues\u2014immune lineages (eosinophil/basophil), neural (Purkinje cell maturation), cardiac (endocardial cushion, cardioblast fate), ear (otic vesicle), and endocrine processes (thyroid and parathyroid hormone-related regulation), plus BMP signaling responses. This points to a cluster of proteins involved in broad developmental differentiation programs rather than a single, unified pathway.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0030222","count":7},{"id":"GO:0030221","count":7},{"id":"GO:0021691","count":7},{"id":"GO:2000611","count":7},{"id":"GO:0003197","count":7}]},{"hash":"1267843998029073769","title":"Nuclear DNA maintenance and transcription","description":"This cluster is dominated by GO terms for DNA replication, DNA repair, DNA-templated transcription, and mitotic cell cycle, indicating core nuclear DNA metabolism and gene expression during cell division. mRNA export from the nucleus supports a broader theme of nuclear gene expression, while other terms appear as secondary noise. ","confidence":"High","size":8,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":8},{"id":"GO:0006281","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0006406","count":5}]},{"hash":"105257655651931490","title":"Dopaminergic Neurotransmission and Drug Response","description":"This cluster is dominated by neural signaling terms, especially dopaminergic synaptic transmission, and behavioral responses to drugs (cocaine and morphine), with supporting visual processing terms indicating brain- and sensory-processing roles. Peripheral terms such as prostaglandin response and macrophage chemotaxis are present but less central, so the core theme is dopamine-mediated neural signaling and drug-related behaviors.","confidence":"Medium","size":8,"edges":10,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0002035","count":7},{"id":"GO:0007601","count":7}]},{"hash":"1302503074628773178","title":"Neural Development and Epigenetic Regulation","description":"The cluster centers on neural development terms, notably cerebral cortex development and negative regulation of neurogenesis, with related neural signaling (negative regulation of serotonin secretion). It also includes epigenetic regulation components (alternative splicing via spliceosome, DNA methylation, histone demethylation) and apoptosis signals, suggesting a theme of neural development coupled with gene regulation. Some terms like spermine catabolism and auxin biosynthesis are less connected and may reflect broader regulatory roles or annotation noise, but the core neural development and regulation signal is present.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021987","count":2},{"id":"GO:0046208","count":1},{"id":"GO:0000380","count":1},{"id":"GO:0014063","count":1},{"id":"GO:0010269","count":1}]},{"hash":"441285551713754383","title":"Flavonoid biosynthesis and related metabolism","description":"Most of the top GO terms point to biosynthetic and metabolic processes involving small molecules and secondary metabolites (e.g., anthocyanin-containing compound biosynthetic process, flavonoid-related glucuronidation, carbohydrate and lipid biosynthesis, biphenyl catabolic and antibiotic biosynthetic processes). A few annotations (like paranode axon localization) seem less related, suggesting some annotation noise. Overall, the cluster appears enriched for biosynthetic/metabolic activities, especially flavonoid/anthocyanin pathways, justifying this label. ","confidence":"Medium","size":8,"edges":7,"triangles":4,"max_degree":4,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0052696","count":4},{"id":"GO:0008360","count":4},{"id":"GO:0005975","count":4},{"id":"GO:0009718","count":4},{"id":"GO:0002175","count":4}]},{"hash":"2225247406023892662","title":"Cardiac conduction and action potential regulation","description":"The top GO terms overwhelmingly point to heart electrical activity and rhythm control: AV node action potential, atrial depolarization, ventricular membrane repolarization, and regulation of heart rate by cardiac conduction. While a few outliers touch on hypoxia, chemokine production, or apoptosis, the core signal is cardiac electrophysiology, justifying a label focused on cardiac conduction and action potential regulation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":5},{"id":"GO:0001666","count":5},{"id":"GO:0086091","count":5},{"id":"GO:0086016","count":5},{"id":"GO:0060307","count":5}]},{"hash":"383901537636419146","title":"Amino acid and central carbon metabolism","description":"This cluster shows strong signals for energy- and amino acid\u2013metabolism processes, including gluconeogenesis, pyruvate metabolism, ketone body biosynthesis, and leucine biosynthesis/catabolism, pointing to central carbon flux and amino acid turnover. Peripheral terms like sodium transport and a sparse transcription signal are less representative of the core theme. Overall, the proteins appear to be involved in amino acid and central carbon metabolism.","confidence":"High","size":8,"edges":7,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006814","count":3},{"id":"GO:0019878","count":3},{"id":"GO:0006094","count":3},{"id":"GO:0006552","count":3}]},{"hash":"668577407806032270","title":"Spliceosome-Mediated mRNA Processing","description":"Most top GO terms point to spliceosome-mediated mRNA processing, including mRNA splicing, alternative splicing regulation, splice-site recognition, and related maturation steps. The presence of an export term (mRNA export from nucleus) and translation initiation factor assembly suggests coordination between splicing, mRNA export, and the onset of translation, consistent with a cohesive spliceosome/mRNA processing module.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006406","count":4},{"id":"GO:0000380","count":4},{"id":"GO:0060211","count":4},{"id":"GO:0045292","count":4},{"id":"GO:0016556","count":4}]},{"hash":"349180481134126651","title":"Lipid metabolism regulation and lipoprotein processing","description":"The dominant GO terms cluster around lipid handling, including positive regulation of lipoprotein lipase activity, cholesterol and triglyceride metabolic regulation, and chylomicron remnant clearance, plus sphingolipid metabolism. These together suggest a cohesive theme of lipid homeostasis and lipoprotein processing. A few non-lipid terms (NF-kappaB signaling, prostate gland development) appear but with low support, likely incidental. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051006","count":2},{"id":"GO:0090181","count":2},{"id":"GO:0090207","count":2},{"id":"GO:0034382","count":2},{"id":"GO:0033578","count":2}]},{"hash":"60975508429087779","title":"MHC II antigen processing, presentation, and phagocytosis","description":"The cluster is dominated by GO terms for antigen processing and presentation via MHC class II, along with regulation of T cell antigen presentation and phagocytosis, indicating a cohesive immune module focused on antigen handling and initiation of adaptive responses.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055072","count":7},{"id":"GO:0019731","count":7},{"id":"GO:0045646","count":7},{"id":"GO:0042026","count":7},{"id":"GO:0002587","count":7}]},{"hash":"867769508203047149","title":"Mesodermal development and EMT with RNA processing","description":"The cluster centers on mesodermal development and related morphogenetic processes (mesoderm development, cartilage morphogenesis, EMT in heart cushion formation) and includes regulatory aspects of gene expression (mRNA splicing, transcriptional control). This points to a cohesive theme of developmental differentiation, particularly mesodermal/EMT-driven morphogenesis, modulated by RNA processing and transcription regulation. Confidence: Medium","confidence":"","size":8,"edges":8,"triangles":1,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010729","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0010957","count":3},{"id":"GO:0003198","count":3}]},{"hash":"2085897349155151780","title":"Embryonic development and morphogenesis","description":"The top terms cluster around developmental and morphogenetic processes across tissues, including mesoderm development, cartilage and hair follicle morphogenesis, epithelial-to-mesenchymal transition in heart development, and trophoblast giant cell differentiation. This suggests a unifying theme of developmental differentiation and tissue morphogenesis, despite a few broader transcriptional regulation terms present. ","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010729","count":7},{"id":"GO:0060707","count":7},{"id":"GO:0010957","count":7},{"id":"GO:0003198","count":7},{"id":"GO:0060536","count":7}]},{"hash":"1388625237602778018","title":"Negative Regulation of Developmental and Immune Processes","description":"The top terms are all negative regulation annotations across diverse contexts: development (endocardial cushion EMT, ectodermal fate commitment, mammary gland proliferation, megakaryocyte differentiation, oenocyte delamination) and immune signaling (NK T cell proliferation, T cell receptor signaling). This points to a cohesive theme of repressive control across multiple pathways, making the label representative of the cluster\u2019s function.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035155","count":1},{"id":"GO:0033600","count":1},{"id":"GO:0003199","count":1},{"id":"GO:0001712","count":1},{"id":"GO:0045653","count":1}]},{"hash":"39697261034144433","title":"Neural development and synapse assembly","description":"The top terms cluster around nervous system development and synapse assembly, with cell\u2013cell adhesion (homophilic and heterophilic) supporting neural connectivity. While there are outliers related to ER protein folding and DNA replication, the dominant signal is neural development and synaptic adhesion.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0007156","count":3}]},{"hash":"899067872274817115","title":"Spliceosome-mediated mRNA splicing regulation","description":"The proteins are enriched for GO terms related to splicing via the spliceosome, including both positive and negative regulation of mRNA splicing, alternative splicing, and mRNA export, suggesting a cohesive splice-regulatory module involved in RNA processing.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0048025","count":3},{"id":"GO:0010610","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0031047","count":3}]},{"hash":"1029597448821960055","title":"Vacuolar amino acid transport under nitrogen stress","description":"This cluster is dominated by GO terms for transporting amino acids into the vacuole (histidine, glutamate, tyrosine, lysine) and related nutrient signaling (glutamine transport, nitrogen starvation response), pointing to a theme of vacuolar amino acid handling and nitrogen status. A few terms (long-term synaptic depression, centrosome localization, substrate-dependent cell migration) are less directly connected and may reflect broader cellular trafficking contexts, but the core signal is vacuolar amino acid transport and nutrient stress response.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":2},{"id":"GO:0051660","count":2},{"id":"GO:0006929","count":2},{"id":"GO:0089708","count":1},{"id":"GO:0090515","count":1}]},{"hash":"1547718351082681247","title":"Unknown","description":"The GO terms are scattered across diverse biological processes (phosphatase activity regulation, follicle cell development, triglyceride storage, NFAT signaling, dephosphorylation, epithelial\u2013mesenchymal transition, kinetochore localization, Schwann cell development, locomotion) with no clear, shared function or pathway tying the proteins together, and there are no network connections among them. Therefore, there is no coherent label beyond Unknown.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032516","count":2},{"id":"GO:0030707","count":2},{"id":"GO:0030730","count":2},{"id":"GO:0051533","count":1},{"id":"GO:0016311","count":1}]},{"hash":"2042186093816305957","title":"Unknown","description":"The top GO terms cover a mix of integrin signaling and cell migration, ubiquitin processing, mitochondrial fission, and neuronal development, with several obsolete terms. This diversity provides no single cohesive function to label the cluster confidently, so an Unknown label is most appropriate.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014911","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0010863","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0051044","count":2}]},{"hash":"2009356304524958981","title":"Translational Initiation and Regulation","description":"The top GO terms cluster around translation initiation, reinitiation, and formation of the translation preinitiation complex, along with regulation of translational initiation and related viral translation processes, suggesting these proteins primarily function in initiating and controlling translation; a few developmental or proliferative terms appear as secondary contexts.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0002188","count":4},{"id":"GO:0048142","count":4},{"id":"GO:0008283","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0006446","count":4}]},{"hash":"1821881448591719541","title":"TGF-\u03b2/BMP Signaling in Embryonic Development","description":"The top GO terms cluster around TGF-\u03b2 receptor signaling and SMAD-associated processes, with negative regulation of BMP signaling, plus multiple developmental events (neural crest differentiation, foregut morphogenesis, brainstem development, cardiac proliferation) and extracellular matrix assembly, suggesting a developmental program governed by TGF-\u03b2/BMP pathways and ECM dynamics.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007183","count":6},{"id":"GO:0007179","count":6},{"id":"GO:0003360","count":3},{"id":"GO:0030514","count":3},{"id":"GO:0048922","count":3}]},{"hash":"419647253905262128","title":"Unknown","description":"The GO terms are spread across nuclear/cell-cycle processes (DNA replication, DNA repair, kinetochore localization) and diverse developmental and trafficking terms (placenta development, Schwann cell development, EMT, Golgi retention), with no clear single function tying all proteins together. Therefore, a cohesive, specific label isn\u2019t evident.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0001893","count":2},{"id":"GO:0045053","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0031047","count":2}]},{"hash":"1292505033571683822","title":"DNA replication and nucleotide salvage cluster","description":"This cluster\u2019s top GO terms center on DNA-templated transcription and DNA replication, together with multiple nucleotide salvage pathways (AMP, IMP, XMP, uracil, guanine). The presence of negative regulation of transcription and protein homooligomerization suggests coordinated control via protein complexes. Taken together, the terms indicate a DNA metabolism-focused group tied to nucleotide salvage rather than a single enzymatic function.","confidence":"High","size":8,"edges":22,"triangles":27,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0044209","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0051260","count":3},{"id":"GO:0007595","count":3}]},{"hash":"1788980288883841270","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0009432","count":2},{"id":"GO:0006310","count":2}]},{"hash":"1502301335963786759","title":"Ubiquitination-driven NF-\u03baB signaling and antiviral defense","description":"The Top Terms cluster around ubiquitination processes (autoubiquitination, various ubiquitin linkages) and ubiquitin-dependent protein degradation, together with regulation of NF-\u03baB signaling and antiviral defense. While a peroxisomal import term appears, the dominant theme is ubiquitin-modified regulation of immune signaling and defense against viruses, suggesting these proteins function in ubiquitin-dependent control of antiviral responses.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":4},{"id":"GO:0042787","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0070534","count":3}]},{"hash":"189987915437777827","title":"Glycan Biosynthesis and Cell Wall Assembly","description":"The cluster centers on polysaccharide and cell envelope biosynthesis, with GO terms like cell wall organization, teichoic acid and mycolate synthesis, cellulose production, UDP-glucose metabolism, and hyaluronan biosynthesis, indicating a shared function in glycan formation and cell wall assembly. Some terms (myelination, immunoglobulin production) are less related, but the dominant signal is glycan- and cell-wall-related biosynthesis.","confidence":"Medium","size":8,"edges":8,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":3},{"id":"GO:0017000","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0071769","count":2},{"id":"GO:0030244","count":2}]},{"hash":"1865379453680416852","title":"Unknown","description":"The terms span lipid homeostasis, gene expression regulation, tissue cell-number homeostasis, immune beta selection, protein ubiquitination, response to mechanical stimuli, osteoclast development, organismal growth, and heart contraction, with no clear single theme binding the cluster. The presence of an obsolete GO term further reduces cohesion, so a specific, descriptive label is not warranted.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055091","count":3},{"id":"GO:0010628","count":3},{"id":"GO:1990967","count":3},{"id":"GO:0048873","count":3},{"id":"GO:0043366","count":3}]},{"hash":"482639496168659374","title":"Unknown","description":"The GO terms cover very diverse functions, including immune defense (defense against Gram-positive bacteria; phagolysosome assembly), growth/metabolism signaling (TORC1 regulation; glucose signaling), basic cellular processes (peroxisome targeting; rRNA maturation; arginine methylation), and specific secretory/organ functions (pancreatic juice secretion). There isn\u2019t a single cohesive theme that ties all proteins together, so a concise, representative label cannot be confidently assigned.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0050830","count":5},{"id":"GO:0035264","count":5},{"id":"GO:1904263","count":5},{"id":"GO:0010255","count":4},{"id":"GO:0006625","count":4}]},{"hash":"1881207521781939817","title":"Plant diterpenoid and alkaloid biosynthesis","description":"Dominant GO terms include ent-kaurene oxidation to kaurenoic acid (a key step in gibberellin/diterpene biosynthesis), oxylipin biosynthesis, and isoquinoline alkaloid metabolism, all hallmark features of plant secondary metabolism. While some annotations are broad, the cluster most plausibly represents proteins involved in plant terpenoid and alkaloid biosynthesis and related lipid signaling.","confidence":"Medium","size":8,"edges":25,"triangles":41,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0060137","count":7},{"id":"GO:0009822","count":7},{"id":"GO:0031408","count":7},{"id":"GO:0010241","count":7},{"id":"GO:0033280","count":7}]},{"hash":"1565726702950803816","title":"Plant flavonoid and lignin metabolism","description":"The top GO terms point to biosynthesis and modification of plant secondary metabolites, notably anthocyanins and related flavonoids (anthocyanin and cyanidin glucoside biosynthesis, flavonoid glucuronidation), as well as lignin metabolism and related processes. Additional terms include genistein response and antibiotic metabolism, reinforcing a theme of plant defense and pigment/structural metabolite pathways. A single term about paranode axon localization seems outlier noise. Overall, the cluster is best described by plant flavonoid and lignin metabolic processes.","confidence":"High","size":8,"edges":13,"triangles":6,"max_degree":7,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":7},{"id":"GO:0052697","count":6},{"id":"GO:0052696","count":6},{"id":"GO:0071412","count":6},{"id":"GO:0030259","count":6}]},{"hash":"623926595452873566","title":"Protein and polyamine acetylation","description":"The top GO terms are dominated by acetylation-related processes: N-terminal/peptidyl acetylation (including propionylation), spermine and putrescine acetylation, and related acetylation/catabolic steps. This strongly suggests a cohesive theme around acetylation modifications of proteins and amines, with other terms like mycothiol biosynthesis and leaf formation appearing as outliers or annotation noise. Overall, a unifying label is the acetylation-centric cluster.","confidence":"Medium","size":8,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046208","count":4},{"id":"GO:0017198","count":4},{"id":"GO:0018003","count":4},{"id":"GO:0010125","count":4},{"id":"GO:0032920","count":4}]},{"hash":"1786133017464037575","title":"Ribosome Biogenesis and mRNA Export","description":"Based on the top GO terms, two strong signals point to nuclear/nucleolar processes: ribosome biogenesis and maturation of LSU-rRNA, plus mRNA export from the nucleus. While other terms (lung development, copulation, various stress responses) appear, the core enrichment centers on ribosome assembly and RNA processing, suggesting this cluster mainly reflects nucleolar ribosome biogenesis and mRNA export activity.","confidence":"Medium","size":8,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0030324","count":2},{"id":"GO:0072719","count":2}]},{"hash":"1490960101463263572","title":"Unknown","description":"The GO terms span animal development, plant secondary metabolism, vitamin D/retinoic acid signaling, lipid-derived pathways, and metal ion responses, with no cohesive unifying function across the cluster; this mix suggests annotation noise or multi-kingdom components rather than a single biological theme.","confidence":"","size":8,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0060137","count":2},{"id":"GO:0009822","count":2},{"id":"GO:0031408","count":2},{"id":"GO:0010241","count":2}]},{"hash":"1960339937637995129","title":"Unknown","description":"The set includes insulin signaling, cytokinin signaling, MAPKKK cascade regulation, TLR signaling, rhodopsin/photoreceptor signaling, and several separate catabolic processes (lactose, glucosinolate, cellulose). These terms span across diverse organisms and biological themes, with no clear, unified function linking the proteins, so a concise, representative label isn\u2019t supported.","confidence":"","size":8,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":1},{"id":"GO:0019512","count":1},{"id":"GO:0019762","count":1},{"id":"GO:0090080","count":1},{"id":"GO:0009736","count":1}]},{"hash":"49813771056662338","title":"Lipid metabolism and organelle organization","description":"The top GO terms cluster around lipid handling (lipid droplet organization, triglyceride and galactolipid biosynthesis, fatty acid catabolism) and membrane/ER dynamics (endoplasmic reticulum organization), with additional signals of nuclear envelope remodeling (nucleus organization, lamin depolymerization) and related cell-cycle processes. This suggests a cohesive theme linking lipid metabolism to organelle/membrane organization, even though a few terms imply broader nuclear functions. Confidence: Medium","confidence":"","size":8,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":3},{"id":"GO:0034389","count":3},{"id":"GO:0019375","count":3},{"id":"GO:0007029","count":3},{"id":"GO:0019432","count":3}]},{"hash":"781658233154221632","title":"Calcium signaling in immune and sensory processes","description":"The top GO terms emphasize calcium-related signaling (inositol trisphosphate biosynthesis, calcium ion transport) alongside immune and sensory roles (B cell receptor signaling regulation, bitter taste perception, GABA signaling, labyrinthine layer development). This suggests a shared theme of calcium-mediated signal transduction affecting both immune and sensory pathways, with some terms reflecting development or regulation of immune cells. Therefore, a calcium signaling-centric label is appropriate, though some terms are peripheral.","confidence":"Medium","size":8,"edges":11,"triangles":5,"max_degree":6,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007343","count":8},{"id":"GO:0032959","count":8},{"id":"GO:0006816","count":8},{"id":"GO:0050859","count":8},{"id":"GO:2000560","count":8}]},{"hash":"2103717153895483195","title":"Unknown","description":"The top GO terms show a mixture of immune-related processes (neutrophil chemotaxis, T cell costimulation, platelet activation, cell adhesion) and transport/metabolic processes (copper/iron/arsenate transport, nitrate assimilation, lignin catabolic process), plus plant-specific lignin metabolism. Because there isn't a single coherent function or pathway tying these terms together for this protein cluster, a concise, representative label cannot be assigned beyond Unknown.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030593","count":3},{"id":"GO:0031295","count":3},{"id":"GO:0007157","count":3},{"id":"GO:1901684","count":3},{"id":"GO:0046274","count":3}]},{"hash":"463795437088957448","title":"Plant Development and Chlorophyll Biosynthesis","description":"The top GO terms point to plant-specific biology, with chlorophyll biosynthetic process and stamen formation (both plant development) being prominent. Coexisting terms for ubiquitin-dependent protein catabolic process and proteasome assembly suggest a role in protein turnover supporting development. Some terms are more general, but the strongest signal is a plant developmental/protein-homeostasis theme, despite no observed edge connectivity in this cluster.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015995","count":2},{"id":"GO:0006511","count":2},{"id":"GO:0048455","count":2},{"id":"GO:0043248","count":2},{"id":"GO:0038166","count":1}]},{"hash":"2203686484685589749","title":"Neuronal actin remodeling and endocytosis","description":"The cluster is dominated by GO terms for actin dynamics (ruffle assembly, actin filament polymerization), Rho signaling, endocytosis, and dendritic spine maintenance, all pointing to cytoskeletal remodeling and membrane trafficking in neurons. While a few terms touch on peroxisomes, insulin signaling, and ER stress translation, the strongest and most represented theme is actin-driven remodeling supporting endocytosis and spine maintenance in neural contexts.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0097178","count":3},{"id":"GO:0060152","count":3},{"id":"GO:0030838","count":3},{"id":"GO:0046626","count":3},{"id":"GO:0006897","count":3}]},{"hash":"2122087718687003002","title":"Cholesterol and Lipid Metabolism in Developing Tissues","description":"The cluster consistently shows cholesterol-related terms (cholesterol metabolic process, transport) and other lipid/energy pathways (ketone body catabolic process, propionyl-CoA biosynthesis, isoleucine catabolic process), alongside development terms for brain, liver, and adipose tissue. This suggests proteins involved in lipid and energy metabolism active in developing tissues, with mitochondrial regulation hinted by the apoptosis-related term. Overall, a coherent lipid/energy metabolism theme across developing organs.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0046952","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0001889","count":4},{"id":"GO:0006550","count":4},{"id":"GO:0008203","count":4}]},{"hash":"1369056189885726255","title":"Unknown","description":"The terms span diverse developmental and cellular organization processes across tissues (brain, skin) and various localization/regulation activities, with no clear shared function to tie the cluster together.","confidence":"","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006998","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0010514","count":1},{"id":"GO:0061383","count":1},{"id":"GO:0051835","count":1}]},{"hash":"2132607335776461743","title":"Autonomic GPCR Signaling in Cardiovascular and Secretory Tissues","description":"The top GO terms point to GPCR signaling, heart contraction modulation, vascular smooth muscle contraction, and saliva secretion, suggesting a cohesive theme of autonomic regulation of cardiovascular and secretory functions via GPCR pathways. Some terms about immune cell chemotaxis are related through shared receptor signaling, but the core signal appears GPCR-driven autonomic control.","confidence":"Medium","size":8,"edges":26,"triangles":44,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":8},{"id":"GO:0033861","count":6},{"id":"GO:0031649","count":6},{"id":"GO:2000420","count":6},{"id":"GO:0001997","count":6}]},{"hash":"778609996590346567","title":"Zona Pellucida Binding and Proteoglycan Biosynthesis","description":"The cluster\u2019s top terms center on sperm binding to and penetration of the zona pellucida, plus biosynthetic processes for proteoglycans and glycosphingolipids, pointing to extracellular matrix interactions and membrane glycosylation relevant to fertilization and tissue remodeling. Some other terms appear unrelated or broader, but the core theme is ZP interaction and glycosylation pathways.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":4},{"id":"GO:0008542","count":3},{"id":"GO:0018146","count":3},{"id":"GO:0048147","count":3},{"id":"GO:0007341","count":3}]},{"hash":"1471626860639189954","title":"Ribosome biogenesis and RNA processing","description":"The top GO terms cluster around ribosome-related activities: translation, maturation of SSU rRNA, and small subunit ribosome assembly, which point to ribosome biogenesis. Additional RNA-processing activity (spliceosome-mediated splicing) and transcription are consistent with RNA metabolism linked to ribosome production. The presence of viral process and nucleotide/urate/xanthine transport terms may reflect peripheral associations or annotation noise, but the core theme appears to be RNA metabolism and ribosome assembly.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0006351","count":2}]},{"hash":"175335497657699927","title":"Nuclear transport and transcription regulation","description":"The top GO terms point to nuclear-focused functions: transcription regulation by RNA polymerase II, mRNA export from the nucleus, ribosomal subunit export, and protein localization to the nucleus. This suggests a cluster of proteins involved in nucleocytoplasmic trafficking and coordination of transcription with nuclear localization and ribosome biogenesis, with some accompanying cell-cycle (centrosome/kinetochore) and stress-response signals. Overall, the dominant theme is nuclear transport and transcription regulation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0006406","count":5},{"id":"GO:0010824","count":5},{"id":"GO:0034501","count":5},{"id":"GO:0042176","count":5}]},{"hash":"2240960450055856832","title":"Iron-sulfur cluster biogenesis and central metabolism","description":"The proteins are enriched for iron-sulfur cluster assembly and protein maturation, and also for core metabolic processes (glycolysis, TCA cycle, glucose metabolism, and branched-chain amino acid catabolism), suggesting a functional cluster centered on Fe-S protein maturation connected to energy metabolism. Some terms (nitrogen fixation, cerebellar cortex development) are odd or obsolete annotations and likely reflect cross-species or non-specific associations rather than the main function.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0006880","count":2},{"id":"GO:0051604","count":2},{"id":"GO:0016226","count":2},{"id":"GO:0009399","count":2}]},{"hash":"2301973439192915001","title":"Mitophagy and mitochondrial proteostasis","description":"The GO terms center on autophagy of mitochondrion and positive regulation of mitophagy, plus ubiquitin-dependent degradation via the multivesicular body pathway, pointing to mitochondrial quality control and coordinated proteostasis as the cluster\u2019s main theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904669","count":2},{"id":"GO:0043162","count":2},{"id":"GO:0045620","count":1},{"id":"GO:0000422","count":1},{"id":"GO:2000134","count":1}]},{"hash":"435565938610602168","title":"Organelle Biogenesis and Trafficking","description":"The top GO terms point to assembly and maintenance of organelles and their membranes (mitochondrial respiratory chain complex IV assembly, mitochondrial translation, ER inheritance, ER stress response, protein transport into membranes, ER-dependent peroxisome organization, nuclear pore complex assembly). This suggests a cohesive theme of organelle biogenesis and membrane trafficking, with some related but less central terms appearing (e.g., bitter taste perception). Overall, the cluster appears to group proteins involved in coordinating organelle assembly and protein targeting.","confidence":"Medium","size":8,"edges":6,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":3},{"id":"GO:0070131","count":1},{"id":"GO:0034976","count":1},{"id":"GO:0007084","count":1},{"id":"GO:0048309","count":1}]},{"hash":"1958057641957302162","title":"GPCR Signaling Regulation in Cardiovascular and Neural Contexts","description":"The top GO terms point to regulation of GPCR signaling and related pathways (positive regulation of GPCR signaling, serotonin receptor signaling, GTPase activity), together with cardiovascular-related processes (heart contraction regulation, smooth muscle contraction) and neural/immune signaling (dopamine secretion regulation, dendritic cell chemotaxis). This pattern suggests a cluster centered on GPCR-mediated signaling across cardiovascular, neural, and immune contexts rather than a single enzyme or pathway, hence a concrete but broad label. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":7},{"id":"GO:0031649","count":7},{"id":"GO:2000420","count":7},{"id":"GO:0001997","count":7},{"id":"GO:0045745","count":7}]},{"hash":"926317238769510143","title":"GPCR-Mediated Cardiovascular Signaling","description":"The terms point to GPCR signaling and its regulation, including adrenergic effects on heart contraction, serotonin receptor pathways that modulate adenylate cyclase, and vascular smooth muscle contraction. This suggests a coherent theme of GPCR-driven signaling governing cardiovascular function, with a few broader or peripheral terms reflecting general signaling roles in immune/neural contexts.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":8},{"id":"GO:0031649","count":8},{"id":"GO:2000420","count":8},{"id":"GO:0001997","count":8},{"id":"GO:0045745","count":8}]},{"hash":"67255304610148","title":"Unknown","description":"The GO terms show a broad mix of processes (membrane tubulation, transcriptional regulation, GPCR signaling, signal transduction, metabolism, muscle differentiation, prostaglandin response, and cell migration) with no clear shared function or pathway linking the proteins, and there are no edges connecting them, so there\u2019s no coherent functional theme to label beyond Unknown.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903527","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0010572","count":1},{"id":"GO:0030845","count":1},{"id":"GO:0009966","count":1}]},{"hash":"1612218655362944066","title":"ECM Remodeling, Angiogenesis, and Coagulation","description":"The terms point to extracellular matrix remodeling (collagen catabolic process, extracellular matrix disassembly) and associated vascular/hemostatic processes (angiogenesis, positive regulation of plasminogen activation and fibrinolysis, blood coagulation, Factor XII activation). Hypoxia response and development terms (multicellular organism development, amelogenesis) fit with tissue remodeling and formation during growth or healing. Together, these terms suggest a cluster centered on ECM remodeling coupled with angiogenesis and coagulation during development or wound repair.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001666","count":4},{"id":"GO:0030574","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0010756","count":3}]},{"hash":"1036372781739506105","title":"Embryonic neural and sensory organ development","description":"Most terms point to embryonic development of neural tissues and sensory organs (e.g., metencephalon and midbrain-hindbrain boundary development, eye development, and somite specification). While a couple terms relate to plant processes and an obsolete term, the dominant pattern across the cluster is vertebrate embryonic patterning and organ development.","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0051216","count":3},{"id":"GO:0009718","count":2},{"id":"GO:0022037","count":2},{"id":"GO:0009722","count":2}]},{"hash":"2013958212763357023","title":"Eye and Brain Development","description":"The cluster is dominated by eye-related terms (retina development, camera-type eye development, visual perception) and neural development terms (metencephalon, midbrain-hindbrain boundary development), with additional embryonic patterning signals (somite specification, hindlimb morphogenesis). This points to a vertebrate sensory and neural development theme, with eye/vision and brain formation as the core, while heart development and keratinization are likely ancillary terms. ","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":3},{"id":"GO:0007626","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0031424","count":2}]},{"hash":"1169614842375333132","title":"Embryonic Neural and Craniofacial Development","description":"The top GO terms point to development of neural structures (trigeminal ganglion, dopaminergic neurons, metencephalon/midbrain-hindbrain boundary) and craniofacial features (roof of mouth, eye, somite-derived head structures) during embryogenesis. While a few terms are broader embryonic processes (fertilization, digestive tract), the shared theme is embryonic formation of neural and craniofacial structures, justifying this label.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0061551","count":3},{"id":"GO:0071542","count":3},{"id":"GO:0007338","count":3},{"id":"GO:0048565","count":3},{"id":"GO:0060021","count":3}]},{"hash":"259974935224355756","title":"Chaperone-assisted folding and SRP membrane targeting","description":"This cluster is dominated by GO terms for chaperone-dependent protein refolding, unfolded protein response, and SRP-dependent cotranslational targeting to membranes, pointing to roles in protein maturation and delivery to membranes. Negative regulation terms related to heat stress and inclusion body assembly further support a proteostasis/refolding theme. A single DNA replication term is present but does not define the overall function of the cluster, which centers on chaperone-assisted folding and membrane localization.","confidence":"Medium","size":7,"edges":4,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0000742","count":3},{"id":"GO:1903751","count":3},{"id":"GO:1900035","count":3}]},{"hash":"2123525453963652983","title":"Ubiquitin Deubiquitination","description":"Dominant GO terms point to various ubiquitin deubiquitination activities (monoubiquitinated protein deubiquitination, depolymerization of ubiquitin chains, K29- and linear-linked deubiquitination) and ERAD-related processing, suggesting a core theme of ubiquitin editing and protein quality control. Other terms like mitochondrial fission or centrosome duplication are less representative of the cluster\u2019s main signal. Thus the label reflects the central function tying the majority of terms together.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035520","count":4},{"id":"GO:0010995","count":4},{"id":"GO:0000266","count":4},{"id":"GO:0034729","count":4},{"id":"GO:0051298","count":4}]},{"hash":"957792612697224588","title":"Unknown","description":"The GO terms cover a highly diverse set of processes\u2014from nervous system and cardiac development to plant seed morphogenesis and reproductive duct formation\u2014with additional, unrelated cellular regulation processes (miRNA silencing, endocytic recycling). There isn\u2019t a single cohesive biological function tying these proteins together, so there is no clear, representative label.","confidence":"","size":7,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0048936","count":6},{"id":"GO:0035852","count":6},{"id":"GO:0045856","count":6},{"id":"GO:0021520","count":6},{"id":"GO:0048317","count":6}]},{"hash":"469188950005874735","title":"Unknown","description":"The top GO terms are highly diverse, covering blood-related processes (platelet aggregation), neural development (axonogenesis, motor neuron fate), cell localization and trafficking (pole plasm localization, slow endocytic recycling), immune regulation (T cell homeostasis), development in various tissues (duct and seed morphogenesis), and RNA silencing. This lack of a single cohesive biological theme makes it hard to assign a meaningful, specific label beyond Unknown.","confidence":"","size":7,"edges":13,"triangles":8,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070527","count":5},{"id":"GO:0048936","count":4},{"id":"GO:0035852","count":4},{"id":"GO:0045856","count":4},{"id":"GO:0021520","count":4}]},{"hash":"448330429214191100","title":"Nuclear import and meiotic chromosome organization","description":"The top GO terms cluster around nuclear transport processes (ribosomal protein import into nucleus, NLS-bearing protein import into nucleus, nuclear pore complex assembly) and meiosis-specific chromosome organization (meiotic chromosome condensation, synaptonemal complex assembly, kinetochore localization). This suggests a group of proteins involved in nuclear import machinery and meiotic chromosome structuring.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006610","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0060188","count":4},{"id":"GO:0042176","count":4},{"id":"GO:0006607","count":4}]},{"hash":"1599791620989894208","title":"Ribosome biogenesis and SSU maturation","description":"The cluster is defined by strong signals for ribosome biogenesis, small subunit assembly/biogenesis, SSU-rRNA maturation, and translation, indicating a cohesive set of proteins involved in ribosome production and protein synthesis.","confidence":"High","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0042254","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0031564","count":2},{"id":"GO:0042274","count":1}]},{"hash":"1459906760046786680","title":"Schwann cell development and PNS myelination","description":"The top terms show clear emphasis on Schwann cell development and myelination in the peripheral nervous system, indicating a glial/neural focus. While some terms (e.g., epithelial-to-mesenchymal transition and locomotion) can relate to migratory processes of neural crest\u2013derived cells, these fit within the context of glial precursor migration and differentiation. Other signals like NFAT and glucocorticoid pathways may reflect broader regulatory roles in nerve development or glial biology.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051533","count":7},{"id":"GO:0032516","count":7},{"id":"GO:0001837","count":7},{"id":"GO:0034501","count":7},{"id":"GO:0014044","count":7}]},{"hash":"988095259933877515","title":"Thermogenesis and GPCR signaling","description":"The top GO terms point to temperature-related responses (diet-induced thermogenesis, cellular response to temperature stimulus) and GPCR pathways that activate adenylate cyclase (including dopamine and prostaglandin signaling). Additional terms for blood pressure regulation and energy metabolism (electron transport chain) support a theme of metabolism-linked, GPCR-driven signaling tied to thermogenic and vascular responses. Confidence in the shared theme is Moderate, as the terms span related but not identical processes. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0071502","count":5},{"id":"GO:0010579","count":4},{"id":"GO:0007190","count":4}]},{"hash":"1822759708440286533","title":"Neurodevelopment and synaptic plasticity regulation","description":"The cluster\u2019s terms converge on neural development and connectivity, including axonogenesis, astrocyte development, and regulation of synaptic plasticity, as well as calcium channel activity. Cytoskeletal remodeling and cell-shape/adhesion processes (actin cytoskeleton, integrin biosynthesis) support neuronal growth and synapse formation, making the neural development and plasticity theme the most representative link across these proteins.","confidence":"High","size":7,"edges":15,"triangles":13,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0008360","count":2},{"id":"GO:0014002","count":2},{"id":"GO:0045113","count":2}]},{"hash":"1844230155726312983","title":"Multi-tissue development and protein localization","description":"Top terms cluster around tissue-specific development (hippocampus and substantia nigra; keratinocyte development and keratinization) and protein trafficking/localization (Golgi localization; protein localization to plasma membrane). This suggests a function in differentiation across tissues with associated trafficking processes. The presence of an immune-related term is less central to the core theme.","confidence":"Medium","size":7,"edges":9,"triangles":5,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021766","count":6},{"id":"GO:0003334","count":6},{"id":"GO:0051291","count":6},{"id":"GO:0051683","count":6},{"id":"GO:0021762","count":6}]},{"hash":"552188633449735300","title":"Embryonic brain and sensory organ development","description":"The top GO terms cluster around neural development (forebrain, metencephalon, midbrain-hindbrain boundary) and sensory organ formation (eye, inner ear), plus craniofacial structures (roof of mouth/palate) and somite-related patterning, all pointing to coordinated embryonic development of brain and sensory organs. The inclusion of transcriptional regulation supports a developmental regulatory role. ","confidence":"High","size":7,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0060021","count":6},{"id":"GO:0022037","count":4},{"id":"GO:0030917","count":4},{"id":"GO:0043010","count":4}]},{"hash":"1411915442005910274","title":"Developmental Growth Regulation","description":"The proteins in this cluster collectively map to growth control and morphogenesis (negative regulation of cell proliferation and organ growth; embryonic foregut morphogenesis; central complex development), as well as cellular architecture and trafficking (actin cytoskeleton organization; endosome transport; phagolysosome assembly) and tissue remodeling (EMT; glial BBB establishment). This combination suggests a theme of regulating tissue growth and morphology through cytoskeletal dynamics, trafficking, and developmental signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0046621","count":2},{"id":"GO:0030866","count":2},{"id":"GO:0001837","count":2}]},{"hash":"919138739685490222","title":"Mitotic ubiquitin-dependent proteolysis (APC/SCF)","description":"This cluster is dominated by ubiquitin-mediated protein degradation tied to mitosis and cell-cycle control, with enrichment for APC- and SCF-dependent catabolic processes and K11-linked ubiquitination, pointing to regulated degradation of mitotic proteins via the proteasome.","confidence":"High","size":7,"edges":4,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0070979","count":4},{"id":"GO:0031145","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0030433","count":3}]},{"hash":"657284759678333660","title":"NF-kB\u2013driven transcription and immune response","description":"The top terms point to NF-kappaB signaling and DNA-templated transcription, alongside several immune-related processes (neutrophil chemotaxis, T cell anergy regulation) and xenophagy. This pattern suggests a cluster centered on transcriptional regulation of immune signaling with autophagy-linked defense, with some DNA metabolism/telomere-related terms as secondary connections. Overall, the shared theme is transcriptional control of immune pathways and related autophagic responses.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":2},{"id":"GO:0006351","count":2},{"id":"GO:1905765","count":2},{"id":"GO:0061819","count":2},{"id":"GO:0030593","count":1}]},{"hash":"1112631286948473833","title":"Developmental cell fate regulation","description":"The terms cluster around regulation of cell fate decisions and developmental processes across diverse tissues (ectodermal fate, EMT in heart valves, mammary gland processes, structure regression) and include miRNA transcription, implying broad developmental regulation rather than a single pathway.","confidence":"Medium","size":7,"edges":12,"triangles":10,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035155","count":5},{"id":"GO:0033600","count":5},{"id":"GO:0003199","count":5},{"id":"GO:0001712","count":5},{"id":"GO:0045653","count":5}]},{"hash":"1090652894582856278","title":"Epithelial cytoskeleton and brush border assembly","description":"The top GO terms point to epithelial adhesion and cytoskeletal organization, including integrin-mediated adhesion, stress fiber regulation, and structures like the brush border and terminal web. EMT also reflects epithelial remodeling, while signaling terms such as cAMP response and NOS activity suggest regulatory pathways that modulate this cytoskeletal/adhesion framework. Together, these indicate a coherent theme around epithelial cytoskeleton, polarity, and surface structure formation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033628","count":4},{"id":"GO:0051497","count":3},{"id":"GO:1904970","count":3},{"id":"GO:0050957","count":3},{"id":"GO:0051835","count":3}]},{"hash":"699279945501188446","title":"Stimulus-Responsive Chromatin Regulation","description":"This cluster combines proteins involved in responding to external stimuli (EGF and glucocorticoid signals) with regulators of gene expression through chromatin and epigenetic marks (DNA methylation, histone methylation, and chromatin organization), plus helicase activity regulation. The co-occurrence of signaling (ERK cascade, growth factor and steroid responses) and chromatin remodeling suggests these proteins act to modulate transcription in response to cellular signals, including some immune-related regulation such as IgA isotype switching. Confidence reflects the integration of signaling and chromatin-based mechanisms, though the presence of some lineage- or process-specific terms introduces some ambiguity.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051096","count":3},{"id":"GO:0070373","count":2},{"id":"GO:0071364","count":2},{"id":"GO:0071385","count":2},{"id":"GO:0048298","count":2}]},{"hash":"742871967364830492","title":"Vertebrate embryonic development and organogenesis","description":"The GO terms are dominated by vertebrate development-related processes (forebrain development, neural tube closure, skeletal system development, multicellular organism growth/development) and transcriptional regulation, which together suggest a cluster of proteins involved in embryogenesis and tissue formation. The presence of mitotic cell cycle and ER-stress\u2013related apoptotic signaling hints at coordination of proliferation and cell fate during development. An outlier term is defense response to Gram-positive bacteria, which is less connected to the core developmental theme. Overall, the cluster appears to reflect vertebrate developmental and organogenesis functions.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050830","count":6},{"id":"GO:0030900","count":5},{"id":"GO:0070059","count":5},{"id":"GO:0001501","count":5},{"id":"GO:0001843","count":5}]},{"hash":"921257045953511304","title":"Embryonic morphogenesis and patterning","description":"The top GO terms cluster around developmental processes such as roof of mouth development, cartilage morphogenesis, left-right pattern formation, endocardial cushion EMT, and pancreatic cell development, suggesting a theme of embryonic tissue formation and patterning. Some general cellular processes (ribosomal export, mRNA splicing) appear but do not override the developmental signal.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0060021","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0060972","count":4}]},{"hash":"1163949572341142252","title":"Membrane Ion Transport","description":"Most terms cluster around transport across membranes: zinc ion, monoatomic cation, calcium, and polyamine transmembrane transport, plus calcium release from the Golgi. There are also outliers related to lipopolysaccharide biosynthesis and epoxygenase P450 pathways, which are less central to the core theme. Overall, the proteins seem to be tied to membrane transport and metal ion handling, with some noise from related metabolic processes.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"establishment or maintenance of cell polarity","top_go_terms":[{"id":"GO:0009103","count":4},{"id":"GO:0071577","count":4},{"id":"GO:0099132","count":4},{"id":"GO:0019373","count":4},{"id":"GO:1903515","count":4}]},{"hash":"1113694826021809704","title":"Cardiac development and contraction regulation","description":"Based on the top GO terms, most proteins are linked to heart development and regulation of cardiac muscle contraction, including both positive and negative modulation of contraction and signaling (e.g., GPCR desensitization and GTPase regulation). While a few terms touch on fat cell differentiation or ossification, the dominant theme is heart/cardiac muscle biology, suggesting this cluster represents cardiomyocyte development and contractile control.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0045444","count":4},{"id":"GO:0031914","count":3},{"id":"GO:0045988","count":3},{"id":"GO:0060452","count":3}]},{"hash":"1461009894173674190","title":"Neural development and motor neuron differentiation","description":"The Top Terms are dominated by neural development and differentiation of spinal cord motor neurons, interneurons, and related neural lineages (e.g., spinal cord motor neuron differentiation, ventral spinal cord interneuron specification, medial motor column neuron differentiation, spinal cord motor neuron cell fate specification, Purkinje/granule precursor signaling, retinal horizontal cell localization). While there are a couple of non-neural organogenesis terms (roof of mouth development, metanephric vesicle morphogenesis), the prevailing theme is neurodevelopment, particularly motor neuron specification. ","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":3},{"id":"GO:0021937","count":2},{"id":"GO:0072283","count":2},{"id":"GO:0035852","count":2},{"id":"GO:0035584","count":2}]},{"hash":"99547087009545798","title":"Unknown","description":"The top GO terms span diverse processes\u2014from cytoskeletal dynamics and GTPase signaling to neural development, metabolism, ribosome maturation, and organelle targeting\u2014indicating no single cohesive function tying the cluster together. This makes a specific, representative label difficult.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030042","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0060041","count":3},{"id":"GO:0010255","count":2}]},{"hash":"1960245331801697540","title":"Phototransduction and Visual Signaling Cluster","description":"Based on recurring GO terms centered on phototransduction, visual perception, and regulation of opsin-mediated signaling, this cluster most likely groups proteins involved in light sensing and downstream visual signaling. The inclusion of terms related to synaptic plasticity and Schwann cell development suggests additional roles in neural signaling and glial support, consistent with a vision-related neural network.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0022400","count":4},{"id":"GO:0007602","count":4},{"id":"GO:0007614","count":3}]},{"hash":"122853681103329729","title":"Ubiquitin-Dependent Endocytosis and MVB Sorting","description":"The proteins cluster around ubiquitin-related processes and endocytic trafficking through the multivesicular body (MVB) pathway, including ubiquitin-dependent protein catabolism and vacuolar transport. While a few terms touch on Drosophila oogenesis (follicle cell and germarium-derived egg chamber formation), the dominant GO terms emphasize ubiquitin regulation, endocytosis, and MVB sorting, indicating a cohesive theme of ubiquitin-mediated degradation via endosomal/vacuolar routes.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":2},{"id":"GO:0007291","count":2},{"id":"GO:1904669","count":2},{"id":"GO:0044130","count":2},{"id":"GO:0043162","count":2}]},{"hash":"2007409934150808878","title":"DNA Damage Response and Repair","description":"These proteins collectively map to core DNA damage response and repair processes: translesion synthesis (both error-free and error-prone), the G1 DNA damage checkpoint, homologous recombination-based double-strand break repair, and telomere maintenance via recombination. The ubiquitin-related term suggests regulation of DDR signaling. Some terms like viral process and ABA response may be cross-annotation noise, but the dominant theme is lesion tolerance and repair via TLS and HR, plus checkpoint control.","confidence":"High","size":7,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070987","count":3},{"id":"GO:0031571","count":3},{"id":"GO:0042276","count":3},{"id":"GO:0000722","count":3},{"id":"GO:0000724","count":3}]},{"hash":"876958326328663499","title":"Unknown","description":"The Top Terms span several unrelated domains (immune-related processes like platelet activation, leukocyte tethering, T cell homeostasis, and phagolysosome assembly; plus non-immune terms like photosynthesis and cerebellar Purkinje cell development), with one obsolete GO term. This lack of a cohesive shared function or pathway makes it hard to assign a meaningful, unified label to the cluster.","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":4,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0010572","count":4},{"id":"GO:0039573","count":4},{"id":"GO:0015979","count":4},{"id":"GO:0090528","count":4},{"id":"GO:0034392","count":4}]},{"hash":"1805103715105021018","title":"Actin remodeling and Ras signaling in cell migration","description":"The cluster is dominated by GO terms tied to actin cytoskeleton organization, lamellipodium assembly, and cell migration, all connected through small GTPase signaling and Ras pathway regulation. While some immune and developmental terms are also present, the core signal points to actin-driven motility and its regulation via Ras signaling.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0016477","count":5},{"id":"GO:0007264","count":5},{"id":"GO:0046580","count":5},{"id":"GO:0002344","count":5},{"id":"GO:0030032","count":5}]},{"hash":"1031924598544292785","title":"Synaptic Vesicle Trafficking and SNARE Assembly","description":"The GO terms consistently point to vesicle transport, Golgi-related trafficking, SNARE complex assembly, and neurotransmitter release/receptor localization at synapses, indicating a cohesive role in exocytosis and synaptic vesicle dynamics.","confidence":"High","size":7,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1903078","count":3},{"id":"GO:0006675","count":3},{"id":"GO:1904050","count":3},{"id":"GO:0051469","count":3},{"id":"GO:0048280","count":3}]},{"hash":"585674269793041308","title":"Mitochondrial fatty acid and branched-chain amino acid catabolism","description":"This cluster's top GO terms concentrate on fatty acid beta-oxidation (long-chain FA, beta-oxidation with acyl-CoA dehydrogenase) and branched-chain amino acid catabolism (L-leucine and L-valine), plus carnitine metabolism, pointing to mitochondrial energy production from lipids and BCAAs. Some terms (liver/heart development, ascaroside biosynthesis) seem less connected and likely noise, but the core signal supports mitochondrial catabolic pathways.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0019439","count":2},{"id":"GO:1904070","count":2},{"id":"GO:0001889","count":2},{"id":"GO:0007507","count":2}]},{"hash":"886878641211773704","title":"GPCR Signaling Regulation in Cardiovascular and Immune Systems","description":"This cluster centers on GPCR-mediated signaling and its cardiovascular and immune-system effects: positive regulation of GPCR signaling, control of heart contraction by catecholamines, vascular smooth muscle contraction, and neurotransmitter signaling (dopamine/serotonin) plus dendritic cell chemotaxis. The mix suggests proteins that modulate GPCR pathways across heart/vascular tissues and immune/neural contexts. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0033861","count":6},{"id":"GO:0031649","count":6},{"id":"GO:2000420","count":6},{"id":"GO:0001997","count":6}]},{"hash":"754177768771573969","title":"Plant cell wall glycoprotein biosynthesis and root hair development","description":"Most terms converge on plant extracellular matrix components and their glycosylation (arabinogalactan proteins, hydroxyproline O-glycosylation), mucilage and seed coat biosynthesis, and root hair formation, suggesting a cohesive theme around plant cell wall glycoproteins and their modifications. A few entries seem insect- or non-plant\u2013specific, likely noise, but the dominant signal supports this interpretation.","confidence":"Medium","size":7,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0030311","count":3},{"id":"GO:0042248","count":3},{"id":"GO:0001744","count":3},{"id":"GO:0018258","count":3}]},{"hash":"1037676868384590273","title":"Immune cell signaling and regulation","description":"The GO terms point to immune system functions across both innate and adaptive immunity, including regulation of NK cell cytotoxicity, macrophage activation, T cell degranulation, B cell activation and signaling, complement activation, phagocytosis recognition, and innate immune responses. While there is a peripheral adhesion term related to tissue structure, the dominant pattern is immune signaling and modulation, justifying this label as representative of the cluster\u2019s theme.","confidence":"High","size":7,"edges":5,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002859","count":6},{"id":"GO:0086072","count":6},{"id":"GO:0007157","count":6},{"id":"GO:0043031","count":6},{"id":"GO:0043318","count":6}]},{"hash":"1872380679832342723","title":"GPCR signaling regulation in cardiovascular and immune systems","description":"The top GO terms emphasize positive regulation of GPCR signaling, cardiac regulation by adrenergic signals, vascular smooth muscle contraction, and immune cell movement, suggesting a cluster centered on GPCR-mediated signaling across cardiovascular and immune contexts.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":7},{"id":"GO:0031649","count":7},{"id":"GO:2000420","count":7},{"id":"GO:0001997","count":7},{"id":"GO:0045745","count":7}]},{"hash":"1054525507194986781","title":"Spliceosome-driven mRNA Splicing and Processing","description":"Top terms show spliceosome-dependent regulation and execution of mRNA splicing, export, and modification, indicating a core function in mRNA maturation and processing; neuronal development annotation is present but likely peripheral to the main theme.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000381","count":5},{"id":"GO:0007399","count":3},{"id":"GO:0006406","count":3},{"id":"GO:0000380","count":3},{"id":"GO:0060211","count":3}]},{"hash":"1087122352764583945","title":"Unknown","description":"Top terms span skin and forebrain development, heart cell apoptotic process, RNA maturation, peroxisome targeting, peptidyl-arginine methylation, GTPase regulation, phagolysosome assembly, and glucose-mediated signaling. The terms are too diverse to reveal a single cohesive function or pathway for the cluster, so a precise, representative label cannot be confidently assigned. ","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0043588","count":5},{"id":"GO:0051260","count":5},{"id":"GO:0010255","count":4},{"id":"GO:0006625","count":4},{"id":"GO:0035246","count":4}]},{"hash":"1387683887808450192","title":"Embryonic development and differentiation","description":"The top GO terms span a range of developmental and differentiation processes across tissues and organ systems (spermatid development, endocrine system development, cartilage morphogenesis, left-right pattern formation, placental/embryonic tissue remodeling, and even sensory organ development). While there isn\u2019t a single precise pathway linking all terms, the common thread is involvement in organismal development and tissue differentiation. One term for gene expression regulation (mRNA splicing) fits the broader context of developmental gene control. This suggests a broad developmental/differentiation role for the cluster rather than a specific functional module.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0003323","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0003198","count":1}]},{"hash":"1521464864471361378","title":"Diverse bacterial biosynthetic pathways","description":"The top GO terms point to several biosynthetic and metabolic processes typical of bacteria (lipopolysaccharide, poly-hydroxybutyrate, antibiotic biosynthesis, stilbene catabolic processes) along with related redox and lipid-related activities. The terms are diverse and do not converge on a single, cohesive function, suggesting a cluster of proteins involved in various microbial biosynthetic pathways rather than a specific, shared role. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0017000","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0009103","count":2},{"id":"GO:0099132","count":2}]},{"hash":"13848193593884804","title":"Diverse Transmembrane Transporters (Ions and Substrates)","description":"The top GO terms point to membrane transport across a broad range of substrates, including xenobiotics, nitrate, galactose, sugars, ions (Na+, K+), vitamins, and related substrates, plus a vesicle neurotransmitter loading process. This cohesive theme centers on transmembrane transport, suggesting the cluster comprises membrane transporter proteins with diverse substrates.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":7},{"id":"GO:0042128","count":7},{"id":"GO:0015706","count":7},{"id":"GO:0071805","count":7},{"id":"GO:0098700","count":7}]},{"hash":"416836482638205353","title":"Ribosome biogenesis and subunit maturation","description":"The proteins are strongly associated with ribosome production, including maturation of SSU/LSU rRNA, assembly of preribosomes and large subunit biogenesis, and formation of translation preinitiation complex, indicating a cohesive group involved in ribosome assembly and maturation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0000463","count":3},{"id":"GO:1902626","count":2},{"id":"GO:0042273","count":2},{"id":"GO:0000462","count":2}]},{"hash":"2214704727813154544","title":"Golgi-ER Trafficking and Secretion","description":"The dominant GO terms point to the secretory pathway: COPI-coated vesicles, COPI coating of Golgi vesicles, Golgi ribbon formation, and protein retention in the ER lumen, plus positive regulation of Wnt protein secretion. A couple of terms about thiamine metabolism/phosphorylation appear as outliers, but the core signal is Golgi/ER trafficking and secretion, suggesting this cluster centers on secretory machinery rather than metabolism. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009229","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0006772","count":2},{"id":"GO:0010745","count":2},{"id":"GO:0006621","count":1}]},{"hash":"902842052822525372","title":"Fertilization and reproductive behavior","description":"The top GO terms cluster around fertilization events (single fertilization; penetration of zona pellucida) and reproductive behaviors (male courtship behavior), with related development and neuromuscular-related terms (locomotory and balance-related processes). This suggests a cohesive theme centered on reproductive biology and associated movement/behavior, with some peripheral metabolic annotations. ","confidence":"Medium","size":7,"edges":7,"triangles":1,"max_degree":6,"top_function":"lysosome organization","top_go_terms":[{"id":"GO:0008360","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0009313","count":4},{"id":"GO:0007626","count":4},{"id":"GO:0050885","count":4}]},{"hash":"2062354136397693834","title":"Neural chemosensory learning via cAMP-PKA signaling","description":"The terms converge on neural signaling (dopamine/adrenergic pathways), cAMP/PKA activation, and memory-related chemosensory processes (olfactory learning, long-term memory, taste detection), suggesting a cohesive theme of learning and sensory processing driven by the cAMP signaling axis.","confidence":"High","size":7,"edges":5,"triangles":2,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007195","count":4},{"id":"GO:0007616","count":4},{"id":"GO:0001582","count":4},{"id":"GO:0034199","count":4},{"id":"GO:0010353","count":4}]},{"hash":"89373239330847604","title":"Cardiovascular GPCR signaling","description":"This cluster\u2019s GO terms converge on GPCR signaling and its regulation, especially as it affects cardiovascular function: positive regulation of GPCR signaling, regulation of heart contraction by epinephrine/norepinephrine, and vascular smooth muscle contraction, plus serotonin/dopamine receptor signaling via GPCR pathways. While a few terms are broader or immune-related, the strongest common theme is GPCR-mediated control of heart and vascular function and associated neurotransmitter signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":7},{"id":"GO:0031649","count":7},{"id":"GO:2000420","count":7},{"id":"GO:0001997","count":7},{"id":"GO:0045745","count":7}]},{"hash":"1064367086558805077","title":"GPCR Signaling in Heart and Immune Regulation","description":"The top GO terms cluster around GPCR signaling and its regulation, with strong ties to cardiovascular effects (epinephrine/norepinephrine\u2013driven heart contraction, vascular smooth muscle contraction) and downstream signaling (GTPase regulation, serotonin receptor pathways). Immune/neural context is also present (dopamine secretion regulation, dendritic cell chemotaxis, eosinophil migration), suggesting a theme of GPCR-mediated signaling impacting heart, vessels, and immune/neural processes.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":7},{"id":"GO:0031649","count":7},{"id":"GO:2000420","count":7},{"id":"GO:0001997","count":7},{"id":"GO:0045745","count":7}]},{"hash":"1905486062699573204","title":"Membrane Transport of Small Molecules","description":"Most terms emphasize transmembrane transport of various solutes (pyruvate, organic anions, arsenite, antimonite, taurine) across the plasma membrane, with some metabolic and unrelated developmental/neural terms acting as noise. The unifying theme is membrane-based solute transport, which justifies this label.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043427","count":1},{"id":"GO:0042413","count":1},{"id":"GO:0033611","count":1},{"id":"GO:0006849","count":1},{"id":"GO:0043251","count":1}]},{"hash":"1590675335544738956","title":"Unknown","description":"The terms are highly heterogeneous: a couple point to insulin receptor signaling/PI3K pathways and GTPase activation, but many others describe biosynthetic or degradation pathways (biotin, methionine [obsolete], beta-ketoadipate, antibiotic biosynthesis) and even P450-related processes and demethylation. With no clear, single functional theme or interactions among the proteins, and no edges connecting them, there isn\u2019t a cohesive biological function to label the cluster beyond Unknown.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":2},{"id":"GO:0014065","count":2},{"id":"GO:0090630","count":2},{"id":"GO:0019260","count":1},{"id":"GO:0009102","count":1}]},{"hash":"110715420065973033","title":"Embryonic development and neural differentiation","description":"The GO terms span diverse developmental processes across tissues (nephric duct morphogenesis, notochord formation, mesoderm development, pericyte differentiation) and neural connectivity (axonal fasciculation, AMPA receptor clustering), with supporting roles for MAPK signaling and apoptosis; the set lacks a single cohesive pathway, suggesting a broad theme of development and neural differentiation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000196","count":1},{"id":"GO:0006915","count":1},{"id":"GO:0007413","count":1},{"id":"GO:0072178","count":1},{"id":"GO:0046061","count":1}]},{"hash":"407722440806509637","title":"Embryonic Development and Organogenesis","description":"The top GO terms cluster around a broad set of developmental and morphogenetic processes across multiple tissues\u2014craniofacial development, pancreatic and endocrine development, placental and placental-associated regulation, EMT in heart cushion formation, hair follicle morphogenesis, cartilage formation, and left-right patterning. This suggests the proteins are involved in general embryogenesis and organogenesis rather than a single pathway or tissue. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":6},{"id":"GO:0003323","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0031069","count":4}]},{"hash":"135281647492335484","title":"Unknown","description":"The GO terms span autophagy, protein processing, immune antigen presentation, xenobiotic response, and various developmental/behavioral traits, with no single cohesive function uniting the set. There isn't a clear, specific theme to name the cluster beyond Unknown.","confidence":"","size":6,"edges":3,"triangles":1,"max_degree":2,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006914","count":3},{"id":"GO:0002018","count":3},{"id":"GO:0008584","count":2},{"id":"GO:0042756","count":2},{"id":"GO:0048469","count":2}]},{"hash":"1062381519067205627","title":"Neuronal fate specification and neural development","description":"The top GO terms are heavily focused on neural development and neuron differentiation, including neuroblast fate determination, noradrenergic and GABAergic neuron differentiation, and auditory receptor/retina development. While a few terms pertain to other tissues or processes, the strongest signal points to neuronal fate specification and neural development as the cluster theme.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007400","count":6},{"id":"GO:0048743","count":6},{"id":"GO:0003407","count":6},{"id":"GO:0061682","count":6},{"id":"GO:0003359","count":6}]},{"hash":"1290877955263502792","title":"Ubiquitin-dependent protein degradation and signaling","description":"The cluster is dominated by multiple ubiquitin-related GO terms (K48, K63, K11-linked ubiquitination; ubiquitin-dependent ERAD; protein autoubiquitination; polyubiquitination) and related processes such as peroxisome protein import, plus links to cell division and necroptosis regulation. This points to a cohesive theme of ubiquitin-mediated protein modification controlling degradation and signaling, rather than a single isolated process.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0070534","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0097039","count":2},{"id":"GO:0070979","count":2}]},{"hash":"578097232994368400","title":"ER-Golgi trafficking and ribosome biogenesis","description":"The top GO terms point to components of the secretory pathway (ER-to-Golgi transport, COPII vesicle budding, ERAD) and ribosome biogenesis, with additional but less central hints of cell division and brain development; the strongest shared theme appears to be proteins involved in intracellular trafficking and ribosome-related protein production.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0090307","count":3}]},{"hash":"206132141213947955","title":"Developmental patterning and tissue differentiation","description":"The top GO terms center on developmental patterning (neural tube, neuromast/lineage, tongue, fat cell differentiation) and tissue-specific proliferation, with additional regulatory processes (transcriptional control, apoptosis, ubiquitination) that modulate development. This points to a cohesive theme of developmental patterning and differentiation across multiple tissues rather than a single biochemical function.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021903","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0045444","count":3},{"id":"GO:0043066","count":2},{"id":"GO:0016567","count":2}]},{"hash":"1101130161642705992","title":"Embryogenesis and placental morphogenesis","description":"The top terms cluster around embryonic development and placental/extraembryonic differentiation (e.g., pancreatic cell development, trophoblast differentiation, EMT in heart cushion formation, endocrine system development, cartilage morphogenesis, left-right patterning). This suggests a coherent theme of developmental programs guiding tissue and organ formation, with a minor background signal from RNA processing terms. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0035270","count":4}]},{"hash":"1715077951565970318","title":"Unknown","description":"The top GO terms span diverse processes (DNA replication, chromatin/heterochromatin regulation, signaling cascades, focal adhesion, vitamin D metabolism, osmotic/stress responses, development, apoptosis) with no clear shared function across all six proteins, and even plant-specific or obsolete terms. This lack of a coherent, representative theme makes a specific, accurate label unlikely.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0030466","count":3},{"id":"GO:0051893","count":3},{"id":"GO:0070640","count":2},{"id":"GO:0072709","count":2}]},{"hash":"374530510105767904","title":"Ubiquitin-Dependent Proteolysis","description":"The cluster is dominated by GO terms related to ubiquitination and ubiquitin-dependent protein catabolic processes, including general protein ubiquitination and SCF-dependent proteasomal pathways, indicating a core focus on protein tagging for degradation. Additional terms like regulation of transcription, circadian rhythm, and DNA damage checkpoints may reflect regulatory roles connected to proteostasis, rather than a single cohesive pathway beyond ubiquitin-mediated turnover. Overall, the data point to a proteostasis-centered cluster driven by ubiquitin signaling.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0000122","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0031146","count":2}]},{"hash":"458954544679275836","title":"Cilium and centrosome regulation via ubiquitination","description":"The cluster combines post-translational modification and protein turnover signals (sumoylation, ubiquitin-related pathways including K63-linked ubiquitination and ERAD) with ciliopathy-related and centrosomal functions (regulation of non-motile cilium assembly, microtubule anchoring at the centrosome, and localization to the photoreceptor outer segment). This points to a cohesive theme around control of ciliary/centrosomal structure and trafficking mediated by ubiquitin/SUMO-based modification and degradation. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0071357","count":3},{"id":"GO:0045842","count":3}]},{"hash":"2169159330801910475","title":"Diverse Membrane Transporters","description":"The top GO terms are dominated by transmembrane transport activities across various substrates (xenobiotics, sugars, ions, vitamins, phosphate, sugars like galactose and fucose, sialic acid) plus neurotransmitter loading into vesicles. This points to a shared function: proteins that move substances across membranes rather than performing in-place metabolism, i.e., transporter proteins. A single metabolic term (nitrate assimilation) is present but does not outweigh the transport theme.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0015757","count":3},{"id":"GO:1900754","count":3},{"id":"GO:0015739","count":3}]},{"hash":"590574162660674954","title":"ER Folding and ER Stress Response","description":"The cluster is dominated by GO terms related to endoplasmic reticulum protein folding, misfolded protein transport, ERAD, and regulation of translation initiation in response to ER stress, pointing to a coordinated ER quality-control/stress response program. Additional terms about nuclear transport appear as adjacent processes but the ER-focused terms anchor the primary function.","confidence":"High","size":6,"edges":7,"triangles":1,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006469","count":4},{"id":"GO:0035719","count":3},{"id":"GO:1900035","count":3},{"id":"GO:0070843","count":3},{"id":"GO:0034975","count":3}]},{"hash":"581865152340429969","title":"Olfactory learning and memory","description":"The cluster is strongly enriched for terms tied to chemical sensing and learning, including olfactory learning, detection of chemical stimuli for sensory perception, long-term memory, and pheromone-related behaviors (e.g., male mating behavior). Receptor clustering and rhythmic excitation further suggest olfactory circuit function, with acetate response being a less central metabolic note. Overall, the proteins appear to participate in olfactory perception and learning/memory processes.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071311","count":3},{"id":"GO:1900273","count":3},{"id":"GO:0050907","count":3},{"id":"GO:0051930","count":3},{"id":"GO:0007616","count":3}]},{"hash":"1909785819849689813","title":"Axon Guidance and Cytoskeleton Remodeling","description":"The cluster shows enrichment for axon guidance and cytoskeletal-related terms (axon guidance; filopodium and stress fiber assembly) and neuronal development (midbrain dopaminergic neuron differentiation), pointing to roles in neurite outgrowth and synaptic organization driven by actin dynamics. Some terms (cell wall biosynthesis, lymphocyte migration, germ-band shortening) appear less coherent with this theme and may reflect cross-species annotations or noise, but the dominant signal supports neuronal development and cytoskeleton remodeling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007411","count":3},{"id":"GO:0051496","count":3},{"id":"GO:0046847","count":3},{"id":"GO:1904948","count":2},{"id":"GO:0090334","count":2}]},{"hash":"418409645175989562","title":"Actin Cortex Dynamics and Cell Polarity","description":"The cluster is dominated by actin-related terms (actin cortical patch assembly/localization, actin filament polymerization) and cell polarity/cell shape regulation, pointing to actin cytoskeleton organization as the core function; calcium response and mitochondrion localization support related signaling and organelle positioning, while neural development/behavior terms appear less central.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051592","count":6},{"id":"GO:0051654","count":6},{"id":"GO:0000281","count":6},{"id":"GO:0000147","count":6},{"id":"GO:0051666","count":6}]},{"hash":"49603519520221074","title":"Neural development and axon guidance","description":"The cluster is dominated by GO terms for nervous system development, axon guidance, ROBO signaling, and SHH signaling, pointing to neural pathfinding and early neural patterning as the central theme. While terms like kidney development and immune signaling appear, they are less representative of the main function of this cluster.","confidence":"High","size":6,"edges":10,"triangles":6,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":6},{"id":"GO:0035385","count":6},{"id":"GO:0043931","count":5},{"id":"GO:0007411","count":5},{"id":"GO:0050852","count":5}]},{"hash":"231897701637301434","title":"Neural Development and Signaling","description":"The GO terms show a clear emphasis on nervous system development, including hippocampus development and axonogenesis, indicating a neural-development focused cluster. Supporting terms for signaling and regulation (JNK cascade, serine phosphorylation) and protein ubiquitination suggest common post-translational regulation in neural development. Some entries (beta selection, tight junction assembly) seem less related and may reflect broader annotations, but the dominant theme is neural development.","confidence":"Medium","size":6,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050771","count":6},{"id":"GO:0048873","count":6},{"id":"GO:0043366","count":6},{"id":"GO:0021766","count":6},{"id":"GO:0007399","count":6}]},{"hash":"168927900293163854","title":"RNA processing and transcription regulation","description":"The top GO terms cluster around RNA polymerase II transcription initiation/termination, transcription-coupled repair, mRNA export, and maturation of rRNA, indicating a group focused on RNA metabolism and transcription regulation (with some outliers/obsolete terms). ","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006369","count":6},{"id":"GO:0006311","count":5},{"id":"GO:0016973","count":5},{"id":"GO:0000462","count":5},{"id":"GO:0014070","count":5}]},{"hash":"298024367988331990","title":"Proteolysis and peptide processing","description":"The cluster centers on proteolysis and processing of proteins/peptides, evidenced by terms such as proteolysis, protein autoprocessing, amyloid-beta metabolic process, APP processing, and antigen processing via MHC II. Angiotensin maturation and renin-angiotensin regulation reflect hormone peptide maturation, reinforcing the processing theme. A few terms like xylan catabolic process or drinking behavior are outliers, likely noise or broad annotations, but the core signal is proteolytic processing. ","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042756","count":2},{"id":"GO:0001823","count":2},{"id":"GO:0042985","count":2},{"id":"GO:0019886","count":2},{"id":"GO:0016540","count":2}]},{"hash":"2252571489039490315","title":"DNA Damage Response and Proteostasis","description":"This cluster is dominated by GO terms related to DNA repair regulation, apoptosis, and ubiquitin-proteasome\u2013dependent processes (free ubiquitin chains, ERAD, proteasome localization), as well as translesion synthesis and meiotic recombination. Together these indicate a functional theme around DNA damage response and protein quality control via ubiquitin-mediated pathways, with a secondary note of flagellar/meiotic context that is less central. ","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0045739","count":6},{"id":"GO:0006915","count":6},{"id":"GO:0010994","count":6},{"id":"GO:0007288","count":6},{"id":"GO:0030433","count":6}]},{"hash":"826470073488267570","title":"Immune Regulation and Antiviral Response","description":"The terms center on immune regulation (T cell differentiation, B cell activation/proliferation, and T-helper cytokine control) alongside antiviral/innate responses (dsRNA sensing, innate immunity, and suppression of viral replication), with a corticosteroid response indicating inflammatory context; coagulation appears as a secondary inflammation-related process.","confidence":"High","size":6,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045581","count":4},{"id":"GO:0045071","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0042100","count":4},{"id":"GO:2000552","count":4}]},{"hash":"1437926537917638961","title":"Synaptic Transmission and Vesicle Endocytosis Regulation","description":"The top GO terms show regulation of dopamine secretion, GABAergic synaptic transmission, and receptor-mediated endocytosis, pointing to a module that coordinates neurotransmitter release with vesicle recycling. While some terms are unrelated (e.g., plant-specific signaling), the core theme is synaptic signaling and vesicle trafficking. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014059","count":2},{"id":"GO:0048260","count":2},{"id":"GO:0032228","count":2},{"id":"GO:0038028","count":2},{"id":"GO:0051092","count":2}]},{"hash":"1785371199582185033","title":"DNA Damage Response and Ubiquitin-Proteasome Regulation","description":"The top GO terms cluster around DNA repair processes (positive regulation of DNA repair, error-free translesion synthesis), apoptotic signaling, and ubiquitin-related protein quality control (free ubiquitin chain polymerization, ubiquitin-dependent ERAD, proteasome localization). This suggests a cohesive theme where DNA damage response is linked to ubiquitin-mediated proteostasis and protein turnover, with occasional germline or meiosis-related terms that may reflect broader regulation during cell division. ","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0045739","count":6},{"id":"GO:0006915","count":6},{"id":"GO:0010994","count":6},{"id":"GO:0007288","count":6},{"id":"GO:0030433","count":6}]},{"hash":"524464327998514986","title":"Translation regulation and mRNA decay","description":"The cluster is dominated by GO terms tied to protein synthesis and mRNA turnover (translation, regulation of termination and elongation, translational fidelity, and deadenylation-dependent decay) with supportive links to spliceosome dynamics and RNA processing. A few differentiation terms (skeletal muscle, glial, hematopoietic) may reflect context-specific roles but do not outweigh the translation-centered theme. Thus, labeling as translation regulation and mRNA decay captures the core shared function of these proteins.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:1990416","count":3},{"id":"GO:0000388","count":3},{"id":"GO:0006449","count":2},{"id":"GO:0045901","count":2}]},{"hash":"2205044933004369261","title":"Cofactor metabolism and central carbon metabolism","description":"The top GO terms collectively point to metabolism involving essential cofactors (thiamine biosynthesis, tetrahydrofolate metabolism) and central carbon pathways (glycolysis, 2-oxoglutarate metabolism), with a thread of redox homeostasis and environmental stress responses (ethanol, aluminum). This suggests a metabolic core module rather than a single, highly specific pathway.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009228","count":4},{"id":"GO:0045454","count":4},{"id":"GO:0046653","count":4},{"id":"GO:0045471","count":4},{"id":"GO:0010044","count":4}]},{"hash":"1705777609842851736","title":"Ubiquitin-Dependent Degradation and NF-\u03baB Signaling","description":"The dominant GO terms point to ubiquitin-dependent protein catabolic processes and ERAD, coupled with regulation of NF-\u03baB signaling (I\u03baB phosphorylation and non-canonical NF-\u03baB), and TNF-mediated pathways. Immune-related terms like T-helper cell differentiation and spleen development further support a theme of ubiquitin-driven proteolysis regulating NF-\u03baB\u2013mediated immune signaling. This suggests a cohesive cluster of proteins involved in ubiquitin-mediated proteolysis and NF-\u03baB pathway regulation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0030433","count":4},{"id":"GO:1903721","count":3},{"id":"GO:1901224","count":3},{"id":"GO:0045623","count":3}]},{"hash":"892102486143233190","title":"Lipid and sterol biosynthesis","description":"These proteins cluster around lipid metabolic processes, as indicated by terms for unsaturated fatty acid biosynthesis, ergosterol biosynthesis regulation, and sphingolipid metabolism. While some annotations (nitric oxide/nitrate assimilation, mitochondrion inheritance, myelin maintenance, chlorophyll metabolism) are less related and may reflect broader or cross-kingdom annotations, the dominant theme is lipid/sterol biosynthesis and related pathways. Confidence: Medium","confidence":"","size":6,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006809","count":6},{"id":"GO:0006675","count":6},{"id":"GO:0001949","count":6},{"id":"GO:0032443","count":6},{"id":"GO:0042128","count":6}]},{"hash":"1744178459834153927","title":"Bacterial fatty acid catabolism and quinone biosynthesis","description":"The cluster\u2019s top GO terms cluster around fatty acid beta-oxidation, amino acid (valine) and phenylacetate catabolism, and the biosynthesis of quinone cofactors (menaquinone and phylloquinone), all pointing to bacterial central carbon metabolism and quinone-dependent energy processes. The presence of antibiotic biosynthetic process also suggests secondary metabolism common in some bacteria, but the shared theme remains metabolism linked to quinone production and oxidative energy currencies. This combination supports a coherent label focused on bacterial metabolism and quinone biosynthesis rather than disparate processes.","confidence":"Medium","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006635","count":4},{"id":"GO:0010124","count":4},{"id":"GO:0009234","count":4},{"id":"GO:0006574","count":4},{"id":"GO:0017000","count":4}]},{"hash":"1038528440526087920","title":"Neural, cardiac, and skeletal development","description":"The top GO terms cluster around development of nervous system (brain), heart, and skeletal tissues, suggesting a shared role in organogenesis and tissue formation. The presence of Rho GTPase signaling and calcium-dependent exocytosis points to signaling and actin dynamics that guide morphogenesis. A few terms (ABA signaling, pseudohyphal growth) are less aligned and may reflect broad or background associations, but the core theme is developmental programs across multiple tissues.","confidence":"Medium","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0007266","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0001501","count":5}]},{"hash":"2105957522292005467","title":"Antiviral Defense & NF-kB Signaling","description":"The top GO terms cluster around antiviral defense and immune signaling, notably defense response to virus, positive regulation of canonical NF-kappaB signaling, and positive regulation of type II interferon production, which together point to a host antiviral response. Some annotations about endosome transport and stress responses, ossification, or cardiac signaling appear as peripheral or pleiotropic associations, but the core theme fits antiviral immunity and NF-kB/interferon pathways.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046598","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0048227","count":2}]},{"hash":"1521110391102584586","title":"Neural development and axon guidance signaling","description":"The top GO terms cluster around nervous system development, axon guidance and extension, Rac-mediated signaling, and GABAergic synaptic transmission, which together point to neural connectivity and signaling as the core theme. Some terms (ossification, keratinization, angiogenesis) are broader developmental processes and may reflect ancillary functions, but the dominant signal is neural development and axon guidance.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043931","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0016601","count":3},{"id":"GO:0045773","count":3},{"id":"GO:0051932","count":3}]},{"hash":"725625695471608139","title":"Vertebrate embryonic craniofacial and neural development","description":"The top GO terms converge on developmental processes across craniofacial structures (palate), neural regions (metencephalon, midbrain\u2013hindbrain boundary, inner ear), plus skeletal muscle and eye development, all characteristic of vertebrate embryogenesis, suggesting a shared embryonic organogenesis program.","confidence":"Medium","size":6,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":5},{"id":"GO:0006366","count":4},{"id":"GO:0007519","count":4},{"id":"GO:0022037","count":3},{"id":"GO:0030917","count":3}]},{"hash":"1095373447296906797","title":"GPCR Signaling in Cardiovascular and Immune Regulation","description":"The terms cluster around G protein\u2013coupled receptor signaling and its downstream effects: GPCR signaling regulation, GTPase activity, and pathways modulating adenylate cyclase; terms implicating adrenergic control of heart contraction and vascular smooth muscle; plus immune-related terms like dendritic cell chemotaxis and dopamine signaling regulation. This suggests a cohesive module where GPCR signaling governs cardiovascular responses and immune cell movement, with some metabolic/thermogenic association (heat generation).","confidence":"Medium","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":6},{"id":"GO:0031649","count":6},{"id":"GO:2000420","count":6},{"id":"GO:0001997","count":6},{"id":"GO:0045745","count":6}]},{"hash":"1782410978408551191","title":"COPI-mediated Golgi trafficking and Wnt secretion","description":"This cluster is dominated by GO terms tied to the secretory pathway: ER retention, COPI-coated vesicle formation, COPI coating of Golgi vesicles, and Golgi ribbon formation, plus positive regulation of Wnt protein secretion. Together these point to a shared role in ER-to-Golgi trafficking and cargo secretion, making the label representative of the cluster. Some reproduction- or behavior-related terms may reflect annotation pleiotropy rather than core function.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006621","count":2},{"id":"GO:0035964","count":2},{"id":"GO:0061357","count":2},{"id":"GO:0090161","count":2},{"id":"GO:0048205","count":2}]},{"hash":"228230048573931855","title":"Neuronal synaptic regulation and mitochondrial dynamics","description":"The proteins are tied to neural signaling and plasticity (adult locomotory behavior; dopamine uptake in synaptic transmission; endocytosis; negative regulation of excitatory postsynaptic potential) and to mitochondrial dynamics and cellular stress responses (mitochondrial fission and its negative regulation; negative regulation of ROS biosynthetic process). Ubiquitination-related terms (protein monoubiquitination; K48-linked ubiquitination) further suggest protein turnover linked to synaptic maintenance. Together, the cluster appears to coordinate synaptic function with mitochondrial regulation and protein homeostasis.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008344","count":3},{"id":"GO:0006897","count":2},{"id":"GO:0046329","count":2},{"id":"GO:0000266","count":2},{"id":"GO:0090394","count":2}]},{"hash":"653413408311042486","title":"Axon guidance and neural development","description":"The cluster is dominated by GO terms related to neural patterning and connectivity, including axon guidance, the Roundabout signaling pathway, nervous system development, and synapse structural plasticity, indicating a core theme of neural development and axon pathfinding. Some bone formation and mast cell chemotaxis terms appear but are weaker signals, so the primary interpretation centers on neural development functions.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007411","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0043931","count":4},{"id":"GO:0002551","count":4}]},{"hash":"365776958173537941","title":"Skin-associated cytokine signaling and immune regulation","description":"The terms point to cytokine production and signaling (interferon-beta, IL-2, IL-12), regulation of innate immune pathways (TLR signaling), and broader immune modulation, with additional hints from keratinocyte proliferation and cell death processes (apoptosis, necrosis). This suggests a cohesive theme of immune signaling and cytokine regulation in a skin context.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032728","count":2},{"id":"GO:0045086","count":2},{"id":"GO:0043616","count":2},{"id":"GO:0045084","count":2},{"id":"GO:0019221","count":2}]},{"hash":"1336477601099639956","title":"Neuronal axon maintenance and secretory trafficking","description":"This cluster centers on neuronal development and maintenance (efferent axon development in the posterior lateral line nerve; neuron projection maintenance) and is linked to secretory pathway processes (COPI vesicles, Golgi ribbon formation, Wnt secretion) as well as ER retention, pointing to proteins that support axon integrity while coordinating ER-Golgi trafficking and signaling. The presence of mitochondrial transport terms hints at energy support for these processes, aligning with a coherent theme around neuronal projection maintenance and secretory logistics.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006839","count":2},{"id":"GO:0048929","count":2},{"id":"GO:1990535","count":2},{"id":"GO:0006621","count":1},{"id":"GO:0035964","count":1}]},{"hash":"1913256835097777406","title":"Unknown","description":"The GO terms here are highly diverse, covering metabolism, organelle targeting, secretion, ribosome maturation, lysosome assembly, signaling regulation, development, and apoptosis, with no singular process uniting them. Therefore a concise, coherent cluster label cannot be assigned.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0010255","count":3},{"id":"GO:0006625","count":3},{"id":"GO:0030157","count":3},{"id":"GO:0035246","count":3},{"id":"GO:0000462","count":3}]},{"hash":"524850873307822113","title":"Neuronal development and signaling","description":"This cluster is driven by terms tied to neural development and function, such as cerebellum morphogenesis and grooming behavior, alongside IP3 biosynthesis, GTPase signaling, insulin signaling, and apoptotic regulation. While some terms (e.g., response to yeast, lipid tube assembly) are less directly neural, the dominant pattern centers on neural development, signaling, and related stress responses.","confidence":"Medium","size":6,"edges":6,"triangles":1,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0008286","count":6},{"id":"GO:0001878","count":5},{"id":"GO:0060988","count":5},{"id":"GO:0051902","count":5},{"id":"GO:0021587","count":5}]},{"hash":"2079675466276646071","title":"Unknown","description":"The GO terms span xenobiotic transport, signaling regulation (activin/BMP), coagulation, development, and various regulatory processes, with little cohesive functional theme linking all six proteins. Because there is no clear common function across the cluster, a specific label is not justifiable.","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0006855","count":3},{"id":"GO:0032926","count":3},{"id":"GO:0030514","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0042128","count":3}]},{"hash":"1301335222807317154","title":"Bacterial carbohydrate metabolism and cell wall biosynthesis","description":"This cluster shows a consistent theme of sugar metabolism (glycogen biosynthesis, glucose-1-phosphate metabolism, galactose and nucleotide-sugar catabolic processes) together with cell envelope biogenesis (lipopolysaccharide biosynthesis, UDP-N-acetylglucosamine biosynthesis, and cell wall organization), suggesting proteins involved in carbohydrate processing and cell wall assembly in bacteria. A couple of terms (gravity detection and an obsolete term) are outliers, but the overall pattern supports the proposed function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0019255","count":2},{"id":"GO:0019388","count":2},{"id":"GO:0009103","count":2}]},{"hash":"1912574784917048722","title":"Gastrointestinal mucosal immune response and Ig transport","description":"The cluster centers on mucosal immune function in the gut, including GI epithelial maintenance, B cell activation with IL-4 production, cytokine signaling, immunoglobulin transcytosis via the poly-immunoglobulin receptor, and regulation of T and NK cell activity in defense against bacteria, with lipoteichoic acid detection supporting a bacterial sensing role.","confidence":"Medium","size":6,"edges":8,"triangles":1,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030277","count":6},{"id":"GO:0050871","count":6},{"id":"GO:0045404","count":6},{"id":"GO:0042742","count":6},{"id":"GO:0002374","count":6}]},{"hash":"1818011653081462978","title":"Adaptive immune signaling and apoptosis regulation","description":"Top terms indicate adaptive immune response and B cell receptor signaling, supported by PKC activation and actin nucleation regulation, pointing to immune cell activation. The mix of proliferation and apoptotic process terms suggests concurrent regulation of cell fate during immune signaling. Together, these imply a cluster centered on adaptive immune signaling with apoptosis-related regulation.","confidence":"High","size":6,"edges":7,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0014911","count":4},{"id":"GO:1990051","count":4},{"id":"GO:0002250","count":4},{"id":"GO:0071300","count":4}]},{"hash":"1028177796829760583","title":"Glutamatergic Synaptic Transmission and Behavior","description":"The cluster is dominated by GO terms for excitatory synaptic activity (long-term potentiation, neurotransmitter secretion, excitatory postsynaptic potentials) and linked behaviors (social, vocalization, grooming) plus memory and calcium-NFAT signaling, pointing to a cohesive role in glutamatergic synaptic signaling and behavioral regulation; a single heart-development term appears incidental noise.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0007269","count":2},{"id":"GO:0051968","count":2},{"id":"GO:2000821","count":2}]},{"hash":"1335038091122877910","title":"Unknown","description":"The listed GO terms span RNA processing (mRNA splicing, rRNA maturation), protein trafficking (peroxisome targeting), secretion (pancreatic juice secretion), cytoskeletal regulation (Arp2/3 inhibition), signaling and GTPase activity, endolysosomal processes (phagolysosome assembly), and developmental terms (forebrain development). There isn\u2019t a single coherent biological theme linking these terms, suggesting the proteins in this cluster are functionally diverse rather than part of a specific pathway.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0034316","count":4},{"id":"GO:0010255","count":3},{"id":"GO:0006625","count":3},{"id":"GO:0030157","count":3}]},{"hash":"1897440184205019540","title":"Ribosome Biogenesis and Translation Initiation","description":"Translation initiation and SSU-rRNA maturation terms dominate (GO:0002188, GO:0001731, GO:0000462), pointing to ribosome assembly and initiation of translation as the cluster\u2019s core function, with supporting but less coherent signals like peroxisome targeting, glucose signaling, and development annotations likely representing multifunctionality or annotation noise.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0002188","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0010255","count":4},{"id":"GO:0006625","count":4},{"id":"GO:0030157","count":4}]},{"hash":"899656076175732345","title":"Cellular stress response and proteostasis","description":"GO terms are dominated by cellular responses to stress, including unfolded protein response, oxidative stress, metal ion (copper) exposure, and hypoxia. These suggest a common function in maintaining protein homeostasis under stress conditions. A couple of terms about embryonic placenta development/pregnancy are less linked to the stress theme and may reflect broader tissue-specific roles or annotation noise. Overall, the cluster appears to group proteins involved in stress response and proteostasis.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001892","count":2},{"id":"GO:0060136","count":2},{"id":"GO:0071280","count":2},{"id":"GO:1900427","count":2},{"id":"GO:0034620","count":2}]},{"hash":"1655206820149059676","title":"GPCR-Regulated Cardiovascular and Neurotransmitter Signaling","description":"The top GO terms cluster around GPCR signaling and its downstream effects (positive regulation of GPCR signaling; serotonin receptor signaling via adenylate cyclase inhibition; positive regulation of GTPase activity) that influence cardiovascular function (heart contraction, smooth muscle contraction) and neurotransmitter regulation (dopamine secretion). While immune-related terms are present, the dominant theme is GPCR-driven signaling affecting heart/vascular and neurotransmitter pathways, justifying this concise label.","confidence":"Medium","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":6},{"id":"GO:0031649","count":6},{"id":"GO:2000420","count":6},{"id":"GO:0001997","count":6},{"id":"GO:0045745","count":6}]},{"hash":"598379285382903222","title":"Membrane Transport and Ion Homeostasis","description":"This cluster is dominated by transmembrane transport terms (bicarbonate, oxalate, sulfate, fructose, chloride transport) and related processes like regulation of membrane potential and intracellular pH, with an additional link to gastric acid secretion. Together these point to a set of proteins primarily involved in transporting ions and small molecules across membranes and maintaining pH/electrical gradients.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060416","count":2},{"id":"GO:0015701","count":1},{"id":"GO:0051454","count":1},{"id":"GO:0042391","count":1},{"id":"GO:0019532","count":1}]},{"hash":"326060629068427800","title":"Unknown","description":"The top terms span many unrelated processes (glucose signaling, peroxisome targeting, rRNA maturation, phagolysosome assembly, GTPase regulation, forebrain and cardiac development, ERAD, and cell proliferation), and there are no connecting edges among the proteins. This lack of a shared function or pathway indicates no coherent theme for naming, so the cluster is Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010255","count":1},{"id":"GO:0006625","count":1},{"id":"GO:0035246","count":1},{"id":"GO:0000462","count":1},{"id":"GO:0001845","count":1}]},{"hash":"1924542742110171159","title":"Multicellular development and signaling","description":"The top GO terms are dominated by developmental processes affecting tissues and organisms (skin development, retina development, multicellular organism development, cell population proliferation), suggesting a core theme of development. Accompanying terms point to signaling roles (positive regulation of GTPase activity, calcium ion release, protein homooligomerization) that often coordinate differentiation and growth. A few terms (diet-induced thermogenesis, sensory perception of pain) are peripheral but may reflect broader regulatory or sensory development contexts; overall the cluster centers on developmental programs with associated signaling. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0007275","count":2}]},{"hash":"932103252916463781","title":"Tissue morphogenesis and differentiation","description":"This cluster shows GO terms linked to tissue development (inner ear, muscle, hair follicle, lung morphogenesis), cell junction assembly (zonula adherens), and cytoskeletal/organellar processes (microvillus length, melanosome transport), indicating a shared theme of morphogenesis and differentiation across tissues. Some terms are more general (locomotory behavior, germline division), but the overall pattern supports developmental tissue remodeling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0007626","count":5},{"id":"GO:0072137","count":4},{"id":"GO:0060901","count":4},{"id":"GO:0048839","count":4},{"id":"GO:1902910","count":4}]},{"hash":"1204933571053227595","title":"Plant carbon metabolism and immunity","description":"This cluster shows a blend of metabolism-focused GO terms (TCA cycle, glyoxylate cycle, malate metabolism) with plant-specific processes (regulation of photorespiration) and stress/defense signaling (defense response to Gram-positive bacteria), plus redox and cytoskeletal remodeling (microtubule severing) that can accompany stress responses. The common thread appears to be plant-oriented carbon metabolism linked to immune/stress responses, rather than a single unified pathway.","confidence":"Medium","size":6,"edges":5,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0007584","count":2},{"id":"GO:0051013","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0080093","count":1}]},{"hash":"1699292262719734224","title":"Membrane Transporters and Ion Homeostasis","description":"The GO terms cluster around various transmembrane transport processes (bicarbonate, oxalate, sulfate, fructose, chloride) and related aspects of ion balance, such as membrane potential regulation and intracellular pH, pointing to a set of proteins dedicated to transport and homeostasis. A few terms (nucleotide-excision repair, transcription regulation) are less consistent with this theme, likely reflecting multifunctional proteins or annotation noise, but the dominant signal supports transport/ion regulation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006289","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0015701","count":1},{"id":"GO:0051454","count":1},{"id":"GO:0042391","count":1}]},{"hash":"1445105735669045081","title":"Cardiac Development and SA Node Conduction","description":"The top GO terms point to heart development and conduction, including Notch signaling in the heart field, SA node cell action potential regulation, and SA node-to-atrial cell communication, all of which suggest a cluster involved in cardiac development and pacemaker/conduction functions. While a few outliers (e.g., temperature sensation) exist, the dominant theme centers on cardiac processes and signaling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044707","count":2},{"id":"GO:2000340","count":2},{"id":"GO:0003270","count":2},{"id":"GO:0098907","count":2},{"id":"GO:0016477","count":2}]},{"hash":"964670841188070079","title":"Ubiquitin-Dependent Protein Degradation and NF-kappaB Signaling","description":"Based on the GO terms, the cluster centers on ubiquitin-mediated proteolysis (ubiquitin-dependent protein catabolic process, protein ubiquitination) and NF-kappaB\u2013related signaling (NF-kappaB-inducing kinase activation, I-kappaB phosphorylation, TNF signaling), with accompanying histone ubiquitination/catabolic processes that suggest chromatin-level regulation during inflammatory responses and apoptosis. This combination points to a cohesive module of ubiquitin-driven protein turnover linked to NF-kappaB\u2013mediated signaling and cell fate decisions.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0036205","count":3},{"id":"GO:0085020","count":3},{"id":"GO:0070535","count":3},{"id":"GO:1903762","count":3}]},{"hash":"386356687335696944","title":"Chromatin regulation and ubiquitin pathways","description":"These GO terms cluster around nuclear chromatin control and ubiquitin-mediated processes: dosage compensation and X-chromosome inactivation (random inactivation of X chromosome; dosage compensation by inactivation of X chromosome), histone modification and turnover (histone H4-K16 acetylation regulation; histone catabolic process), and ubiquitin-dependent proteostasis (K48-linked ubiquitination; ubiquitin-dependent ERAD pathway). A few items like negative regulation of organ growth and intracellular transport of viral material are peripheral, but the overall pattern points to a module coordinating epigenetic regulation with ubiquitin-mediated protein turnover in the nucleus, potentially linked to X-chromosome regulation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0046621","count":4},{"id":"GO:1903721","count":4},{"id":"GO:0060816","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0009048","count":4}]},{"hash":"2268547506747211421","title":"Unknown","description":"The top GO terms are diverse\u2014ranging from an obsolete oxidation-reduction term to responses to toxins, neural/synaptic processes, pain perception, FSH stimulus response, coronary vasculature development, nitric oxide biosynthesis, receptor clustering, phosphorylation regulation, and cardiac muscle proliferation. With no edges or cohesive function tying these terms together, there isn\u2019t a clear, representative theme for this cluster. ","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0009636","count":2},{"id":"GO:0071372","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0019233","count":2}]},{"hash":"2144565078104861657","title":"Angiogenesis and ECM signaling in development","description":"Based on the top GO terms, the cluster centers on developmental processes with a focus on blood vessel formation and extracellular matrix signaling (angiogenesis, positive regulation of angiogenesis, labyrinthine layer blood vessel development, ECM-cell signaling), supported by related developmental terms (nervous system development, chondrocyte differentiation, regulation of cell growth). Some terms like adaptive immune response and synaptic transmission are less tightly connected, but the core pattern supports a developmental vascular/ECM signaling theme. ","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0035426","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0001525","count":2}]},{"hash":"942108350740263526","title":"Negative regulation of developmental signaling pathways","description":"The cluster repeatedly features GO terms that inhibit activin receptor signaling, BMP signaling, Wnt signaling, and PI3K/AKT signaling, along with developmental processes such as heart formation and endothelial cell migration. This points to a theme of coordinating development by suppressing multiple key signaling pathways.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032926","count":2},{"id":"GO:0007084","count":2},{"id":"GO:0048147","count":2},{"id":"GO:0030514","count":2},{"id":"GO:0051898","count":2}]},{"hash":"1467699144704110732","title":"Unknown","description":"The GO terms are diverse: glycogen catabolic process, memory, calcineurin-NFAT signaling, regulation of cell shape and GTPase activity, EMT, VEGF signaling, and bioluminescence. This lack of a unifying theme makes it hard to assign a concise, representative function to the cluster; thus Unknown.","confidence":"","size":6,"edges":7,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0005980","count":3},{"id":"GO:0007614","count":2},{"id":"GO:0051533","count":2},{"id":"GO:0008360","count":2},{"id":"GO:0008218","count":2}]},{"hash":"1162902404319495953","title":"Unknown","description":"The GO terms are highly diverse, covering endothelial apoptosis regulation, circadian rhythms, muscle differentiation, various immune signaling pathways, ubiquitination regulation, and even plant-oriented processes like phototropism and swimming. There is no clear shared function or pathway linking these proteins, so there isn't a coherent label beyond Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000352","count":2},{"id":"GO:1904431","count":1},{"id":"GO:0042748","count":1},{"id":"GO:0035914","count":1},{"id":"GO:0043380","count":1}]},{"hash":"1292289060223403791","title":"ER stress response and UPR signaling","description":"The cluster centers on endoplasmic reticulum stress and unfolded protein response, including transcriptional regulation in response to ER stress and ER-stress\u2013triggered apoptosis. Although some terms touch metabolism and immune signaling (fatty acid homeostasis, macrophage differentiation, IL-4 response) and circadian rhythm, the core theme is ER stress\u2013mediated transcriptional and apoptotic pathways, with broader metabolic-immune context.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1990440","count":5},{"id":"GO:0055089","count":5},{"id":"GO:1900103","count":5},{"id":"GO:0001080","count":5},{"id":"GO:0030225","count":5}]},{"hash":"109672264364584410","title":"Anthocyanin and lignin biosynthesis","description":"The dominant GO terms center on anthocyanin-containing compound biosynthesis and cyanidin 3-O-glucoside biosynthesis, along with lignin metabolic process, suggesting a cluster of enzymes in the plant phenylpropanoid pathway for flavonoid and lignin production. Some obsolete or unrelated terms (glucuronidation, paranode localization) appear as noise but do not override the main theme.","confidence":"High","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009718","count":4},{"id":"GO:0052697","count":2},{"id":"GO:0052696","count":2},{"id":"GO:0071412","count":2},{"id":"GO:0030259","count":2}]},{"hash":"1943458425921293170","title":"Neural and Immune Development Signaling","description":"The top GO terms point to nervous system development (axonogenesis, hippocampus development, general nervous system development) while also highlighting immune-related signaling (T cell receptor signaling, regulation of respiratory burst, MAPKK/JNK pathway). This suggests the proteins participate in development and signaling across both neural and immune contexts, with dopamine-related signaling further supporting neural involvement. The cluster seems to blend these domains rather than a single, narrow function, hence a neural-immune developmental signaling label.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050771","count":4},{"id":"GO:0043366","count":4},{"id":"GO:0021766","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0033138","count":4}]},{"hash":"2096741822231557448","title":"PNS development and myelination","description":"The top terms include Schwann cell development and myelination in the peripheral nervous system, which strongly point to glial differentiation and maturation in the PNS. While there are a few miscellaneous terms (EMT, kinetochore localization, unfolded protein response), the most representative signals are nervous-system developmental and myelination processes, supporting a label centered on PNS glial development.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051533","count":5},{"id":"GO:0032516","count":5},{"id":"GO:0001837","count":5},{"id":"GO:0034501","count":5},{"id":"GO:0014044","count":5}]},{"hash":"149748131088292264","title":"Calcineurin-NFAT signaling and phosphatase regulation","description":"This cluster is dominated by GO terms related to dephosphorylation and phosphatase activity, including negative regulation of protein kinase activity, protein dephosphorylation, and positive regulation of the calcineurin-NFAT signaling cascade. Other terms reference signaling pathways and cell behavior (VEGF receptor-2 signaling, epithelial to mesenchymal transition, regulation of cell shape), suggesting a broader theme of phosphatase-driven signal modulation affecting morphology and signaling outputs. Some entries like memory terms and bioluminescence appear ancillary or annotation-related rather than central to the core function.","confidence":"Medium","size":5,"edges":6,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":4},{"id":"GO:0006470","count":4},{"id":"GO:0007614","count":3},{"id":"GO:0051533","count":3},{"id":"GO:0008360","count":3}]},{"hash":"1672833857322308892","title":"ER Quality Control and Protein Turnover","description":"These proteins cluster around the ubiquitin-proteasome system and ER quality-control axis: sumoylation, ERAD (ubiquitin-dependent), regulation of proteasomal protein catabolic processes, and ER stress\u2013related apoptotic signaling. The developmental and insecticide-response terms appear as pleiotropic annotations rather than a separate module, so the dominant theme is ER-associated protein quality control and turnover.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":5},{"id":"GO:0002109","count":3},{"id":"GO:1902236","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0021888","count":3}]},{"hash":"1283286440780106583","title":"Unknown","description":"Top GO terms are diverse and span regulation of insulin secretion, myoblast differentiation, transcription, development, immune defense, heat generation, and apoptosis, with no clear shared pathway. This heterogeneity makes it hard to assign a cohesive, specific label to the cluster.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061179","count":2},{"id":"GO:0045662","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0061153","count":2},{"id":"GO:0014009","count":2}]},{"hash":"1930885591658532637","title":"Ossification and extracellular matrix remodeling","description":"Based on GO terms like intramembranous ossification, bone resorption, and collagen catabolic process, the cluster centers on bone development and extracellular matrix remodeling. Basement membrane disassembly and ECM turnover further support this theme. While there are some additional developmental signals (lung branching, thyroid response), the strongest shared function among the proteins is bone formation and ECM dynamics.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001957","count":3},{"id":"GO:2000179","count":3},{"id":"GO:0035593","count":3},{"id":"GO:0097067","count":3},{"id":"GO:0034769","count":3}]},{"hash":"1580054199789232739","title":"Spliceosome Assembly and RNA Processing","description":"Most of the top GO terms point to RNA processing and splicing: spliceosomal snRNP assembly, mRNA splicing via spliceosome, spliceosomal complex assembly, mRNA processing/decapping, tRNA processing, and maturation of SSU-rRNA. This pattern suggests the proteins function together as a RNA splicing/processing module. A couple of terms (response to abscisic acid, hair cycle) are less directly connected and may reflect broader regulatory contexts or annotation noise in a small cluster.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008334","count":4},{"id":"GO:0000387","count":4},{"id":"GO:0006369","count":4},{"id":"GO:0030490","count":4},{"id":"GO:0000290","count":4}]},{"hash":"1053604826888451615","title":"Nuclear transcription regulation and chromatin remodeling","description":"This cluster centers on nuclear gene expression control: terms point to negative regulation of RNA Pol II transcription, chromatin remodeling, and histone modification processes, with supporting signals from transcription termination and mRNA export. A few development- or organ-specific terms and a chloroplast import term appear as potential annotation noise, but the dominant theme is transcriptional regulation and chromatin state. ","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0048733","count":2},{"id":"GO:0036302","count":2},{"id":"GO:0051571","count":2},{"id":"GO:0045038","count":1}]},{"hash":"399576078509879596","title":"Ubiquitin-Dependent NF-\u03baB Signaling","description":"This cluster centers on protein ubiquitination and regulation of NF-\u03baB pathways, including I-kappaB phosphorylation and non-canonical NF-\u03baB signaling, suggesting a core role in ubiquitin-mediated control of immune signaling. The presence of spleen development and T-helper cell differentiation terms supports an immune-related function, tying ubiquitination to NF-\u03baB\u2013driven immune regulation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0016567","count":4},{"id":"GO:0000185","count":3},{"id":"GO:1903721","count":3},{"id":"GO:0030433","count":3},{"id":"GO:1901224","count":3}]},{"hash":"1200861858436906193","title":"Pyrimidine Nucleotide Salvage","description":"The dominant GO terms (UMP salvage, CMP salvage, CTP salvage, and pyrimidine nucleobase metabolic process) indicate a coherent cluster of enzymes involved in salvaging pyrimidine nucleotides. The few other terms are less representative and may reflect broader metabolic or regulatory processes, but the core theme is pyrimidine nucleotide salvage and related phosphorylation steps.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0044206","count":2},{"id":"GO:0006238","count":2},{"id":"GO:0006206","count":2},{"id":"GO:0044211","count":2},{"id":"GO:0016310","count":2}]},{"hash":"1776839615187905768","title":"Unknown","description":"The top GO terms are highly heterogeneous, spanning cofactor biosynthesis, metabolism, post-translational modifications, development, and defense, with no clear shared function; plus there are no interactions (edges) linking the proteins, so there is no cohesive theme to label the cluster.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006777","count":2},{"id":"GO:0050832","count":2},{"id":"GO:0045892","count":2},{"id":"GO:0007113","count":2},{"id":"GO:0021764","count":2}]},{"hash":"418213361429907533","title":"BMP/TGF-\u03b2 signaling in embryogenesis","description":"This cluster centers on BMP/TGF-\u03b2 pathway activity with SMAD complex involvement, plus regulation of BMP signaling and multiple embryonic morphogenesis processes (gastrulation, foregut morphogenesis, brainstem development, dorsal convergence, neuromast deposition). The combination of signaling terms, transcriptional control, and ECM remodeling fits a cohesive role in developmental signaling guiding embryonic tissue formation.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007183","count":3},{"id":"GO:0001702","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007179","count":3},{"id":"GO:0003360","count":2}]},{"hash":"452052422015229131","title":"Neuronal development and synaptic plasticity","description":"This cluster is dominated by neural-related GO terms: axonogenesis, regulation of neuronal synaptic plasticity, memory, calcium channel activity, and astrocyte activation, pointing to neuronal signaling and glial interaction roles. While terms like epithelial-mesenchymal transition and heart contraction are present, they are less central to the core neural theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008360","count":4},{"id":"GO:0001837","count":4},{"id":"GO:0048168","count":4},{"id":"GO:1901387","count":4},{"id":"GO:0007409","count":4}]},{"hash":"523463435610419009","title":"Kidney and lymphatic morphogenesis with cytokine signaling","description":"The top GO terms cluster around organ morphogenesis, especially metanephric (kidney) development and lymph vessel morphogenesis, with concurrent immune signaling activities (interleukin-27 signaling, Th2 cytokine production, chemokine regulation, and STAT phosphorylation). This suggests proteins involved in developmental morphogenesis that are modulated by cytokine/STAT pathways, rather than a single specific tissue function. Confidence reflects this mixed but coherent theme across developmental and signaling processes.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072287","count":3},{"id":"GO:0036303","count":3},{"id":"GO:0072237","count":3},{"id":"GO:0070106","count":3},{"id":"GO:0035745","count":3}]},{"hash":"2131745230955061531","title":"Cell cycle and endosomal trafficking","description":"The top GO terms cluster around cell cycle, cell division, and apoptotic processes, with specific regulation of endosome transport and Rho signaling, suggesting a shared theme of coordinating cell division with intracellular trafficking and cytoskeletal regulation. Some development terms may reflect annotation overlap, but the dominant signal is cell cycle-associated processes plus endosomal transport.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000641","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0000920","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0007049","count":2}]},{"hash":"147030291993759642","title":"Tissue development and wound healing","description":"This cluster converges on tissue formation and repair: wound healing, collagen fibril organization, and heart development point to development and ECM remodeling; apoptotic processes occur during remodeling; immune and neural terms like neutrophil chemotaxis and myelination are associated with injury response and development. Overall, a theme of tissue development and repair.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0042060","count":3},{"id":"GO:0035987","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0051092","count":2}]},{"hash":"1950401212613824702","title":"RNA Processing and Antiviral RNAi","description":"Top GO terms are dominated by RNA processing activities (tRNA, mRNA, miRNA, siRNA, rRNA). This points to a core function in RNA metabolism and small RNA pathways. The presence of innate immune response and negative regulation of viral genome replication supports a link to antiviral defense mediated by RNA interference mechanisms. A couple of neural development terms (facial/hypoglossal nerve morphogenesis, motor behavior) may reflect broader roles of some RNA-processing proteins, but they don't override the main RNA-centric theme.","confidence":"Medium","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0035196","count":2},{"id":"GO:0045071","count":2},{"id":"GO:0016075","count":2}]},{"hash":"347982204159777889","title":"Developmental DNA replication and cell-cycle signaling","description":"The cluster centers on DNA replication and cell-cycle regulation (DNA replication, centrosome cycle, positive regulation of DNA replication, nuclear cell cycle) and includes developmental signaling and differentiation terms (Wnt signaling, Hippo signaling, embryonic cranial skeleton morphogenesis, keratinocyte differentiation) as well as apoptosis, suggesting a theme of coordinating cell proliferation with embryonic development and tissue differentiation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0035329","count":2},{"id":"GO:0060044","count":2}]},{"hash":"1196925236051501604","title":"RNA transcription and ribosome biogenesis","description":"The proteins cluster around transcription by RNA polymerases I, II, and III, including tRNA transcription and elongation/termination by Pol III, together with ribosome biogenesis, suggesting a cohesive group involved in transcriptional machinery and ribosome assembly.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042797","count":2},{"id":"GO:0006360","count":2},{"id":"GO:0006386","count":2},{"id":"GO:0006385","count":2},{"id":"GO:0042254","count":2}]},{"hash":"1581244573401860366","title":"ECM remodeling and bone ossification","description":"Based on the GO terms, the strongest cohesive theme is extracellular matrix (ECM) remodeling and skeletal development: intramembranous ossification, bone resorption, collagen catabolic process, and basement membrane disassembly point to ECM breakdown and bone formation/remodeling. Other terms like neural development or immune activity appear less central to the core signal, which makes the label ECM remodeling with bone ossification a concise, representative name for this cluster.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007614","count":1},{"id":"GO:0001957","count":1},{"id":"GO:2000179","count":1},{"id":"GO:0035593","count":1},{"id":"GO:0097067","count":1}]},{"hash":"130249556951927792","title":"Unknown","description":"The top GO terms span angiogenesis, complement activation, bone formation, Hedgehog signaling, hypoxia response, skeletal/muscle development, and root meristem growth, covering vascular, immune, skeletal, plant, and signaling domains. There is no single cohesive function tying these proteins together, so a specific label isn\u2019t justifiable.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0060346","count":2},{"id":"GO:0045880","count":2}]},{"hash":"2153502127422152239","title":"Developmental Signaling and Morphogenesis","description":"This cluster centers on signaling pathways and processes that drive tissue development and morphogenesis across various contexts (neural, vascular, renal, reproductive), including receptor tyrosine kinase signaling, apoptosis, dendrite/axon development, and cell differentiation, with additional immune signaling components. The common thread is development-related signaling rather than a single tissue-specific function.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007169","count":5},{"id":"GO:0006915","count":5},{"id":"GO:0050773","count":5},{"id":"GO:0072178","count":5},{"id":"GO:0070106","count":5}]},{"hash":"1361994943632663924","title":"Bone and cartilage development","description":"This cluster is dominated by GO terms for skeletal system development, cartilage development, embryonic skeletal joint morphogenesis, and osteoblast proliferation, pointing to proteins involved in bone/cartilage formation and extracellular matrix remodeling (e.g., hyaluronan turnover). Peripheral terms like iron ion homeostasis and germ cell migration do not negate the clear skeletal development signal.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"wound healing","top_go_terms":[{"id":"GO:0001501","count":3},{"id":"GO:0010763","count":3},{"id":"GO:0030308","count":3},{"id":"GO:0043407","count":3},{"id":"GO:0008354","count":3}]},{"hash":"73820700693288221","title":"Oxidative Stress Detoxification","description":"The cluster is dominated by GO terms related to detoxification of oxidants and hydrogen peroxide (cellular oxidant detoxification, hydrogen peroxide catabolic process, response to hydrogen peroxide, response to toxic substance), suggesting that the proteins collectively function to manage oxidative stress. Some tissue-specific terms (blood coagulation, heart development, renal absorption, muscle contraction) may reflect broader roles or organismal context, but the shared theme centers on oxidative stress response and detoxification.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0042744","count":3},{"id":"GO:0007596","count":2},{"id":"GO:0007507","count":2},{"id":"GO:2000490","count":2}]},{"hash":"2237946592009968573","title":"TNF-NF-kappaB Innate Immune Signaling","description":"The terms converge on TNF-mediated signaling and NF-kappaB pathway activation, including IKK activation, I\u03baB phosphorylation, NF-kappaB transcription factor activity, innate immune response, and ubiquitination (notably K63-linked), indicating a cohesive TNF/NF-kappaB signaling module in innate immunity.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1903721","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0007250","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0051865","count":4}]},{"hash":"948525076892992225","title":"Nucleocytoplasmic Transport and Autophagy Regulation","description":"This cluster centers on regulation of nucleocytoplasmic RNA export (tRNA and mRNA), with related roles in ubiquitination and autophagy/mitophagy pathways. The presence of ubiquitination terms and autophagy-related terms alongside nuclear export regulation suggests a coherent theme around trafficking, turnover, and quality control, albeit with some diversity in exact processes.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2000238","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0010793","count":5},{"id":"GO:2000650","count":5},{"id":"GO:0035519","count":5}]},{"hash":"386763367280016735","title":"Ribosome biogenesis and translation","description":"This cluster is clearly enriched for ribosome biology and protein synthesis, with terms for ribosome biogenesis, ribosome assembly, rRNA processing/methylation, and cytoplasmic translation. A few outlier terms (nodulation, virus-endosome fusion, antibiotic biosynthetic process) exist but do not override the dominant ribosome/translation signal.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0031167","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0042254","count":1}]},{"hash":"1226326694546392646","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021957","count":5},{"id":"GO:0043931","count":5},{"id":"GO:0048105","count":4},{"id":"GO:0072137","count":4},{"id":"GO:0060901","count":4}]},{"hash":"723446171565781642","title":"Embryonic brain and eye development","description":"Chosen name reflects the concentration of GO terms related to neural and sensory organ development in the embryo, including retinal ganglion cell axon guidance and camera-type eye development, as well as brain region formation (metencephalon, midbrain-hindbrain boundary). While other terms reference broader embryonic organogenesis (spleen, skeletal, palate), the dominant signal is brain/eye development in the embryonic context.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048536","count":2},{"id":"GO:0009952","count":2},{"id":"GO:0031290","count":2},{"id":"GO:0045617","count":2},{"id":"GO:0048706","count":2}]},{"hash":"984793385846477217","title":"Unknown","description":"The GO terms span diverse processes (glucose signaling, peroxisome targeting, arginine methylation, rRNA maturation, phagolysosome assembly, GTPase regulation, ERAD, and development), with no single, coherent function dominating. Because there isn't a unifying theme, a specific cluster label cannot be confidently assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0010255","count":5},{"id":"GO:0006625","count":5},{"id":"GO:0035246","count":5},{"id":"GO:0000462","count":5},{"id":"GO:0001845","count":5}]},{"hash":"364137730401290394","title":"Neuronal signaling and neural development","description":"This cluster's GO terms consistently point to neural function: dopamine biosynthesis and negative regulation of serotonin secretion indicate neurotransmitter handling, while positive regulation of neural precursor cell proliferation highlights development. Epigenetic processes like histone H3-K4 demethylation and methylation support gene regulation in neural contexts. While glycerol catabolism, apoptosis, and cytolysis are more general, the convergence on neural signaling and development suggests a coherent neuronal-related role for the cluster.","confidence":"Medium","size":5,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019563","count":3},{"id":"GO:0000380","count":2},{"id":"GO:0014063","count":2},{"id":"GO:0042416","count":2},{"id":"GO:0010269","count":2}]},{"hash":"2271680151745882444","title":"Central carbon metabolism and fatty acid biosynthesis","description":"This cluster centers on core energy-producing pathways (glycolysis, TCA, gluconeogenesis, pyruvate to acetyl-CoA) and lipid biosynthesis (malonyl-CoA and long-chain FA synthesis), suggesting a cohesive metabolism-focused group; a minor outlier is sodium transport.","confidence":"High","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":3},{"id":"GO:0006103","count":3},{"id":"GO:0033512","count":2},{"id":"GO:0006814","count":2},{"id":"GO:0006094","count":2}]},{"hash":"1473531867653983200","title":"Transcription initiation and chromatin modification","description":"These proteins share GO terms centered on transcription initiation (DNA-templated transcription initiation; RNA polymerase II preinitiation complex assembly) and chromatin state (histone H3 acetylation), plus regulation of transcription in Notch signaling and development. The mix of transcriptional regulation, chromatin modification, and development-related terms suggests a cluster of factors coordinating gene expression during development through chromatin-based control, with some links to transcription factor stability and RNA processing. ","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":2},{"id":"GO:0006352","count":1},{"id":"GO:0032435","count":1},{"id":"GO:0007221","count":1},{"id":"GO:0030707","count":1}]},{"hash":"1573923602942760185","title":"Neural development and axon guidance","description":"The cluster is dominated by terms tied to neural development and cytoskeletal remodeling, including axon guidance, neural tube closure, actin filament polymerization, and subsynaptic organization, with supporting embryonic morphogenesis terms (germ-band shortening, dorsal opening suture). Some outliers exist, but the core signal points to neural development and cytoskeletal dynamics.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000402","count":1},{"id":"GO:1990255","count":1},{"id":"GO:0000188","count":1},{"id":"GO:1903526","count":1},{"id":"GO:0007390","count":1}]},{"hash":"506288779772167799","title":"TLR-Myd88 Innate Signaling and Chemokine Production","description":"GO terms center on innate immune sensing (TLR/Myd88), dendritic cell cytokine/chemokine production, LPS/LTA detection, and modulation of T cell responses; together with B-1 B cell differentiation and Th1 regulation, indicating a coordinated innate signaling and chemokine-output program.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002730","count":1},{"id":"GO:0002755","count":1},{"id":"GO:0010572","count":1},{"id":"GO:2000340","count":1},{"id":"GO:0032689","count":1}]},{"hash":"2059213381117822435","title":"Meiosis Chromosome Pairing and Transcription Regulation","description":"The cluster\u2019s strongest signals are meiosis-related: chiasma assembly and homologous chromosome pairing at meiosis, along with DNA-templated transcription and its negative regulation, indicating involvement in meiotic chromosome dynamics and transcription control. Some other terms appear less directly related (e.g., responses to antibiotic, maternal processes), but the core pattern points to meiosis-associated chromosome pairing and gene regulation.","confidence":"High","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051026","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0045892","count":2},{"id":"GO:0007129","count":2},{"id":"GO:0046677","count":2}]},{"hash":"1758359476255340318","title":"Immune activation and antibody transport","description":"This cluster is dominated by immune-related GO terms: phagocytosis recognition; cytokine production; positive regulation of B cell and T cell activation and IL-4 production; defense against bacteria; and immunoglobulin transcytosis via pIgR. Although a couple terms touch epithelium maintenance or adipocyte proliferation, the shared functions center on immune system activation and antibody handling, suggesting a coherent immune-response theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006910","count":4},{"id":"GO:0030277","count":3},{"id":"GO:0050871","count":3},{"id":"GO:0045404","count":3},{"id":"GO:0042742","count":3}]},{"hash":"1267726333746596100","title":"Translation Regulation and mRNA Decay","description":"The proteins are strongly associated with translation-related GO terms (translation, regulation of translational termination, elongation, and translational fidelity) and with deadenylation-dependent mRNA decay, indicating a shared role in controlling protein synthesis and mRNA turnover. While some differentiation-related terms appear, the dominant signal is translational control.","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006449","count":2},{"id":"GO:0045901","count":2},{"id":"GO:0000288","count":2},{"id":"GO:0045903","count":2}]},{"hash":"1002659223430680985","title":"DNA Damage Repair and Translesion Synthesis","description":"The top GO terms cluster around DNA repair and damage-tolerance pathways, including nucleotide-excision repair, translesion synthesis (both error-free and error-prone), DNA-templated replication, and cellular response to UV-C, indicating a module of proteins involved in coping with DNA damage and lesion bypass during replication. Some unrelated terms appear, but the core signal strongly supports DNA repair and TLS functions.","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070987","count":3},{"id":"GO:0006297","count":3},{"id":"GO:0006261","count":3},{"id":"GO:0071494","count":3},{"id":"GO:0042276","count":3}]},{"hash":"2080354656124491560","title":"Hair Keratinization","description":"The cluster's top GO terms are keratinization and hair cycle, both pointing to processes in hair follicle biology and keratinocyte differentiation. The proteins appear associated with structural or protective functions in keratinized tissues, suggesting a cohesive role in hair-related keratinization.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":5},{"id":"GO:0042633","count":5}]},{"hash":"144001600461026691","title":"Ubiquitin-Dependent Immune Regulation","description":"The cluster centers on ubiquitin-dependent protein catabolic processes linked to innate immunity, including NF-kappaB regulation and I-kappaB phosphorylation, and overlaps with MHC class I biosynthesis. While some terms are obsolete, the core pattern ties ubiquitin-proteasome\u2013mediated turnover to immune signaling and antigen processing.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0032088","count":3},{"id":"GO:1903721","count":2},{"id":"GO:0033280","count":2},{"id":"GO:0045345","count":2}]},{"hash":"687253198260351177","title":"SCF-Mediated Ubiquitination in Mitosis","description":"The cluster is enriched for ubiquitin-related processes (K11-linked ubiquitination, SCF-dependent ubiquitin-protein catabolic process, and free ubiquitin chain polymerization) and mitotic cell cycle terms (G2/M transition, mitotic cell cycle), indicating a core theme of ubiquitin-regulated proteolysis governing mitosis. Some embryonic development and DNA repair terms appear, but they align with broader cellular regulation rather than overriding the mitotic focus.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070979","count":5},{"id":"GO:0000086","count":5},{"id":"GO:0031146","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0001701","count":5}]},{"hash":"1343281268608332915","title":"Unknown","description":"The top GO terms span extracellular matrix organization, mechanotransduction, neurotransmitter secretion, metabolic regulation, mRNA stability, immune signaling, and environmental stress responses, with no clear single function linking all proteins. The lack of interactions (edges) further supports the absence of a cohesive, shared pathway, so a descriptive, unified label is not confidently identifiable.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":2},{"id":"GO:0010596","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0030199","count":2}]},{"hash":"486596202462389919","title":"Membrane transport and ion homeostasis","description":"Although one term relates to sound perception and another to transcription, the majority of terms describe various transmembrane transport activities (bicarbonate, chloride, sulfate, oxalate, fructose) and a role in membrane potential regulation and intracellular pH, plus gastric acid secretion and general pH/homeostasis. Together, this suggests a cluster of membrane transport proteins involved in ion and small-molecule flux and pH balance.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0015701","count":2},{"id":"GO:0051454","count":2},{"id":"GO:0042391","count":2},{"id":"GO:0019532","count":2}]},{"hash":"226247559007231763","title":"Developmental Patterning Across Tissues","description":"GO terms indicate development and patterning across multiple tissues (ovarian follicle development, imaginal disc leg segmentation, intestinal epithelial development, female meiotic division, and compartment pattern specification). Despite no reported interactions, the common theme is broad developmental biology rather than a single pathway, suggesting a cross-tissue development label.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":2},{"id":"GO:0007386","count":2},{"id":"GO:0001541","count":2},{"id":"GO:1902367","count":2},{"id":"GO:0032092","count":2}]},{"hash":"1992800774161827303","title":"Hair follicle keratinization","description":"These proteins cluster around hair follicle-related processes: keratinization and the hair cycle. The shared theme is epithelial differentiation and keratinocyte organization in hair follicles, so the label reflects the main function of the cluster.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":5},{"id":"GO:0042633","count":5}]},{"hash":"588134063620081174","title":"Innate Immune Activation and Phagocytosis","description":"The top GO terms converge on innate immunity and antimicrobial responses: respiratory burst, positive regulation of phagocytosis and TNF production, TLR2 signaling, and defense against bacteria, plus a general innate immune response. Some terms about metabolic cues (L-glutamine, angiotensin, aldosterone) appear but do not redefine the core theme. The lack of edges means this is a term-driven cluster, but the function is clearly centered on innate immune defense and ROS-mediated antimicrobial activity.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045730","count":3},{"id":"GO:0050766","count":3},{"id":"GO:0032760","count":3},{"id":"GO:0045087","count":3},{"id":"GO:1904845","count":3}]},{"hash":"869112746346618675","title":"Diverse Metabolic Biosynthesis Pathways","description":"This cluster shows enrichment across multiple biosynthetic processes\u2014lipid-related (fatty acid transport/homeostasis, sphinganine biosynthesis), vitamin biosynthesis (biotin), amino acid derivative pathways (kynurenic acid, tryptophan catabolism), and even transcription\u2014suggesting a group of proteins involved in various metabolic biosynthesis activities rather than a single, cohesive function. The mix could reflect plant-associated metabolism and regulation, hence a broad metabolic biosynthesis label.","confidence":"Medium","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0015908","count":4},{"id":"GO:0055089","count":4},{"id":"GO:0033362","count":4},{"id":"GO:0009102","count":4}]},{"hash":"2017077051697295892","title":"Negative regulation of neural development and synaptic signaling","description":"The GO terms focus on dampening neural-related processes: negative regulation of synaptic potentiation, neural precursor proliferation, and dentate gyrus development, plus receptor internalization and related signaling checks. While there are other pathways present (BMP, NF-kappaB), the dominant theme is suppression of neural development and synaptic activity.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0002091","count":1},{"id":"GO:1900271","count":1},{"id":"GO:0030514","count":1},{"id":"GO:0000288","count":1},{"id":"GO:0045671","count":1}]},{"hash":"358599091535897445","title":"Rab-regulated vesicle trafficking","description":"The cluster\u2019s top GO terms cluster around Rab GTPase signaling, endocytosis, and vesicle recycling, with supporting terms for GTPase regulation and basal localization. While apoptosis and immune-related terms appear, the shared signal is vesicle trafficking controlled by Rab proteins, suggesting a cohesive Rab-regulated trafficking function for these proteins.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032483","count":3},{"id":"GO:0035745","count":3},{"id":"GO:0097194","count":3},{"id":"GO:0048488","count":3},{"id":"GO:1902041","count":3}]},{"hash":"1472739055228117593","title":"Unknown","description":"The top GO terms are spread across diverse processes (TGF-beta signaling, T cell receptor signaling, insulin signaling, apoptosis, cerebellum morphogenesis, grooming behavior, GTPase regulation, etc.) with no clear singular function tying the 5 proteins together. There are no network edges to infer a cohesive cluster function, so a specific label isn\u2019t justifiable. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0001878","count":1},{"id":"GO:0060988","count":1},{"id":"GO:0051902","count":1}]},{"hash":"903392659837836779","title":"Immune signaling and protein turnover regulation","description":"The top GO terms point to adaptive immune signaling (B cell receptor signaling; defense response to virus; regulation of dendritic cell apoptosis) together with protein turnover and signaling regulation (ubiquitin-dependent proteolysis; protein dephosphorylation; modulation of MAPK and other pathways). While broader signaling (Rho, Wnt) appears, the dominant themes center on immune signaling and regulation of protein modification/degradation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0050853","count":2},{"id":"GO:0000413","count":2},{"id":"GO:0051607","count":2},{"id":"GO:2000670","count":2}]},{"hash":"2275957713653466516","title":"Arabinogalactan protein glycosylation","description":"GO terms point to glycan synthesis and extracellular glycoprotein biosynthesis, notably arabinogalactan protein metabolism, poly-N-acetyllactosamine biosynthesis, and O-linked hydroxyproline glycosylation, suggesting a shared function in plant cell-surface glycosylation and mucilage/seed coat development; some terms reflect developmental processes that can involve AGP networks.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030311","count":2},{"id":"GO:0042248","count":2},{"id":"GO:0001744","count":2},{"id":"GO:0018258","count":2},{"id":"GO:0010493","count":2}]},{"hash":"1796742490485872795","title":"Spliceosome-mediated mRNA processing and export","description":"These proteins cluster around mRNA maturation: spliceosome-driven splicing (including alternative splicing and splice-site recognition), mRNA export, and regulation of poly(A) tail shortening and other mRNA modifications. This points to a cohesive role in post-transcriptional mRNA processing and regulation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":3},{"id":"GO:0006406","count":2},{"id":"GO:0000380","count":2},{"id":"GO:0060211","count":2},{"id":"GO:0045292","count":2}]},{"hash":"2124411190572822918","title":"Immune defense and fatty acid metabolism","description":"The cluster\u2019s top GO terms include strong innate immune signals (defense response to Gram-positive bacteria and classical complement activation), alongside numerous fatty-acid metabolism terms (long- and medium-chain fatty-acyl-CoA catabolic and biosynthetic processes, palmitic acid biosynthesis). This suggests a set of proteins involved in immune defense with concurrent links to lipid metabolic regulation. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0010124","count":1},{"id":"GO:0045717","count":1},{"id":"GO:0036116","count":1}]},{"hash":"2278288957890499060","title":"NF-\u03baB and TNF signaling regulators","description":"The top GO terms cluster around NF-\u03baB pathway regulation and TNF signaling, including positive regulation of I-kappaB phosphorylation, non-canonical NF-kappaB signaling, TNF-mediated signaling, and regulation of the JNK cascade. Immune-related terms like negative regulation of T-helper cell differentiation and spleen development further support an immune signaling theme. Some items are obsolete or peripheral, but the prevailing pattern points to modulation of NF-\u03baB/TNF\u2013driven signaling in immune responses.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1903721","count":4},{"id":"GO:0030433","count":4},{"id":"GO:1901224","count":4},{"id":"GO:0045623","count":4},{"id":"GO:0048536","count":4}]},{"hash":"2115025791898524601","title":"TNF-NF-\u03baB-JNK Signaling and Apoptosis Regulation","description":"The top GO terms point to TNF-mediated signaling, regulation of JNK cascade, and I-kappaB phosphorylation (NF-\u03baB pathway), along with regulation of apoptotic processes. These together suggest a cluster centered on inflammatory signaling and apoptosis control, with some histone-related terms likely being ancillary noise. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903721","count":2},{"id":"GO:0070535","count":2},{"id":"GO:0033209","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0009048","count":2}]},{"hash":"2089597664819026959","title":"Cardiac mechano-signaling and heart function","description":"The top GO terms cluster around cardiac muscle processes (cardiac muscle cell proliferation, positive regulation of heart rate, positive regulation of cardiac muscle contraction) and a general cellular response to mechanical stimulus, suggesting a set of proteins involved in mechanotransduction and regulation of cardiac function. A couple of terms (myelination, LPS signaling) are broader or less specific to this theme, likely reflecting incidental annotations. Overall, the primary signal is cardiac mechanotransduction and heart function.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060038","count":2},{"id":"GO:0007565","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0031663","count":2},{"id":"GO:0071260","count":2}]},{"hash":"1789343386173802428","title":"Secretory pathway and protein trafficking","description":"The GO terms center on protein retention in the ER lumen, protein transport, and protein secretion, indicating a core theme of the secretory pathway and trafficking. Immune-related terms like innate immune signaling and T cell cytokine production also fit with secretion of immune mediators, though neuronal terms like brain development and neuronal signaling suggest broader roles. Overall, the cluster appears to reflect proteins involved in secretion and trafficking, potentially linked to immune signaling, rather than a single specific process.","confidence":"Medium","size":5,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006621","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0070231","count":1},{"id":"GO:0010204","count":1},{"id":"GO:0002369","count":1}]},{"hash":"445305649843512982","title":"Pentose phosphate shunt and nucleotide biosynthesis","description":"This cluster centers on the pentose-phosphate shunt (including non-oxidative branch) and nucleotide/ DNA precursor metabolism, with several terms for TMP and deoxyribonucleoside biosynthesis and related phosphorylation. The shared theme appears to connect pentose phosphate outputs to nucleotide biosynthesis, indicating a metabolism-focused module related to DNA precursor generation.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":3},{"id":"GO:0006098","count":1},{"id":"GO:0044262","count":1},{"id":"GO:0009052","count":1},{"id":"GO:0019323","count":1}]},{"hash":"2238518267045325793","title":"ER-Golgi vesicle trafficking and nuclear envelope organization","description":"These proteins share GO terms centered on ER organization, Golgi-to-vacuole transport, and localization to the nuclear envelope, plus processes like Golgi ribbon formation and vesicle fusion with the Golgi. The consistent theme is intracellular membrane trafficking and organelle organization across ER, Golgi, nucleus, and vacuole, suggesting a coordinated role in secretory pathway dynamics.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007029","count":2},{"id":"GO:0032781","count":2},{"id":"GO:0071763","count":2},{"id":"GO:0090435","count":2},{"id":"GO:0050882","count":1}]},{"hash":"8493110568457220","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000494","count":2},{"id":"GO:1904751","count":2},{"id":"GO:0008380","count":2},{"id":"GO:1902570","count":2},{"id":"GO:0097309","count":2}]},{"hash":"1952817379124476357","title":"GPCR Signaling in Cardiovascular and Neuroimmune Regulation","description":"This cluster centers on GPCR-mediated signaling with links to catecholamine-regulated heart contraction, vascular smooth muscle activity, and various neurotransmitter pathways (serotonin, dopamine), suggesting a theme of GPCR-driven cardiovascular control and neuroimmune communication. Some immune-cell terms (dendritic cell chemotaxis, eosinophil regulation) hint at broader signaling cross-talk but fit within the GPCR-signaling framework. Confidence: Medium","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":5},{"id":"GO:0031649","count":5},{"id":"GO:2000420","count":5},{"id":"GO:0001997","count":5},{"id":"GO:0045745","count":5}]},{"hash":"1118860660221290634","title":"Inflammation-Driven Angiogenesis and Adhesion","description":"This cluster centers on inflammatory responses (inflammatory response, response to LPS) and immune cell regulation (extrinsic apoptotic signaling, activation-induced T cell death), combined with tissue remodeling features such as cell-matrix adhesion, cell migration in sprouting angiogenesis, and endothelial proliferation in angiogenesis. The mix suggests a theme where inflammation drives vascular remodeling and cell adhesion dynamics. Some terms (e.g., thyroid hormone generation) are less related, but the dominant signal is inflammation-associated angiogenesis and adhesion. ","confidence":"Medium","size":5,"edges":6,"triangles":1,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007160","count":3},{"id":"GO:2001241","count":3},{"id":"GO:0006924","count":3},{"id":"GO:0032496","count":3},{"id":"GO:0006954","count":3}]},{"hash":"2253591295147386588","title":"Cardiovascular GPCR signaling and regulation","description":"This cluster\u2019s top GO terms center on GPCR signaling and its regulation (positive GPCR signaling, serotonin receptor signaling, cAMP/adenylate cyclase pathways, and GTPase activity) and on downstream cardiovascular effects (heart contraction regulation by catecholamines and vascular smooth muscle contraction). While some terms touch immune/neuronal processes, the dominant theme is GPCR-driven signal transduction affecting cardiovascular function. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":5},{"id":"GO:0031649","count":5},{"id":"GO:2000420","count":5},{"id":"GO:0001997","count":5},{"id":"GO:0045745","count":5}]},{"hash":"396599147876461732","title":"Ectodermal neural and epidermal development","description":"The cluster\u2019s GO terms largely point to development of ectoderm-derived tissues: epidermal processes (keratinocyte migration, cornification), neural components (astrocyte and axonogenesis-related terms, axonal transport), and lens fiber development. While a few terms (e.g., muscle contraction) are less aligned, the dominant theme is neural/epidermal differentiation and axon-related dynamics.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051546","count":5},{"id":"GO:0014002","count":5},{"id":"GO:0048936","count":5},{"id":"GO:0031133","count":5},{"id":"GO:0070307","count":5}]},{"hash":"1553485765173402008","title":"Inflammation-driven immunity and coagulation","description":"The cluster's GO terms cluster around immune defense and coagulation: defense response to fungi, leukocyte migration in inflammatory response, and neutrophil-mediated killing, together with blood coagulation and positive regulation of plasminogen activation. This points to proteins involved in coordinating inflammatory responses with clotting processes. Additional signals like fractalkine production and Wnt signaling further support modulation of immune cell activity and inflammatory signaling. The negative regulation of transcription by RNA polymerase II is a less central note but does not outweigh the inflammatory/coagulation theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0001878","count":1},{"id":"GO:0070946","count":1},{"id":"GO:0010756","count":1},{"id":"GO:0007596","count":1}]},{"hash":"1058693184932761467","title":"Unknown","description":"The top GO terms are very diverse (antigen processing via MHC II, transcription, xenobiotic response, autophagy, apoptosis, neurogenesis, chaeta development, cilium-related transport), with no single clear function linking them. This makes it hard to assign a specific, cohesive label beyond Unknown.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019886","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0006914","count":1},{"id":"GO:0006915","count":1}]},{"hash":"1460719999825945676","title":"Neural Development and Sensory Signaling","description":"This cluster is dominated by neural/sensory terms such as visual perception, visual learning, cerebellar cortex formation, axon regeneration, and sensory perception of pain, suggesting a primary theme of neural development and sensory processing, even though a few signaling or development terms are more peripheral.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0048679","count":3}]},{"hash":"861708381553789486","title":"Unknown","description":"These four proteins show a highly diverse set of GO terms, spanning metabolism (TCA cycle, isoleucine catabolic), detoxification (mercury ion detoxification), stress responses (hyperoxia, selenium ion response), plus processes like alternative splicing and regulation of serotonin secretion, and nicotine catabolic activity. The lack of a coherent, shared function or pathway among these terms suggests there is no single underlying theme tying the cluster together. ","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":2},{"id":"GO:0000380","count":2},{"id":"GO:0019608","count":2},{"id":"GO:0014063","count":2},{"id":"GO:0010269","count":2}]},{"hash":"198148532780030902","title":"Unknown","description":"Top GO terms are highly heterogeneous ( vitamin D3 metabolism, sorbitol response, MAPK cascade, multiple developmental processes, apoptosis, stress responses, plant hormone signaling ), spanning diverse tissues and species with no clear shared function. This prevents a coherent, specific label.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070640","count":4},{"id":"GO:0072709","count":4},{"id":"GO:0000196","count":4},{"id":"GO:0060484","count":4},{"id":"GO:0006915","count":4}]},{"hash":"459011652372558825","title":"MAPK-driven stress signaling and development","description":"The cluster includes a prominent MAPK-related term (cell integrity MAPK cascade) along with apoptotic and toxic-stress responses, suggesting a core theme of MAPK-mediated signaling in stress. It also contains several developmental terms across tissues (Schwann cell development, tricuspid valve morphogenesis, lung mesenchyme development), indicating a broader role of signaling in development. Other terms (vitamin D3 metabolism, sorbitol response, ABA signaling) appear peripheral or cross-species, possibly annotation noise. Overall, the strongest cohesive thread is MAPK signaling linked to stress responses and development, justifying this label with medium confidence.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070640","count":4},{"id":"GO:0072709","count":4},{"id":"GO:0000196","count":4},{"id":"GO:0060484","count":4},{"id":"GO:0006915","count":4}]},{"hash":"751515819184592587","title":"Embryonic neural crest and organogenesis","description":"The Top Terms cluster around vertebrate embryonic development, with neural crest differentiation, brainstem formation, lateral line neuromast deposition, dorsal convergence, foregut morphogenesis, and cardiac muscle proliferation, plus nodal signaling and ECM regulation. These points together suggest a cohesive developmental program centered on neural crest\u2013driven processes and organogenesis (heart, foregut) during embryogenesis, with transcriptional regulation as a core mechanism. Negative regulation of cytosolic Ca2+ may reflect signaling modulation during development but does not override the main developmental theme.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0051481","count":3},{"id":"GO:0003360","count":2},{"id":"GO:0048922","count":2},{"id":"GO:0060030","count":2}]},{"hash":"1170624847493821515","title":"Neural and sensory organ development","description":"The GO terms are dominated by nervous system development (forebrain, metencephalon, midbrain-hindbrain boundary, neurohypophysis) and sensory organ formation (inner ear, camera-type eye), indicating a cohesive theme of embryonic neuro-sensory morphogenesis. Some terms also touch on broader developmental processes like somite and limb formation, but the central pattern is neural/sensory development.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048839","count":4},{"id":"GO:0022037","count":3},{"id":"GO:0030917","count":3},{"id":"GO:0043010","count":3},{"id":"GO:0001757","count":3}]},{"hash":"546566100635310047","title":"Proteasome-Mediated Proteolysis and Immune Signaling","description":"This cluster shows enrichment for proteasome core complex assembly and proteolytic processes (ubiquitin-dependent and independent), plus immune signaling terms like T cell receptor signaling and inflammatory regulation. The common thread appears to be proteasome-driven protein turnover influencing immune signaling pathways, with some related pathways (Wnt PCP) suggesting broader regulatory roles.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0080129","count":2},{"id":"GO:0010499","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0051436","count":2}]},{"hash":"606792951959372596","title":"Neural and sensory neuron development","description":"These proteins cluster around developmental programs for neural and sensory lineages. The top GO terms highlight neuroblast fate determination, neural retina development, GABAergic neuron differentiation, auditory receptor cell fate specification, and noradrenergic neuron fate commitment, with transcription by RNA polymerase II as a common underpinning. Although a few terms are broader, the strongest signal is neural/sensory development and cell fate specification.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":2},{"id":"GO:0007400","count":1},{"id":"GO:0048743","count":1},{"id":"GO:0003407","count":1},{"id":"GO:0061682","count":1}]},{"hash":"830813698008185156","title":"rRNA and Peptidyl Methylation","description":"The top GO terms are dominated by methylation processes, including rRNA methylation and methylation of peptidyl residues (lysine, arginine, glycine, glutamine). This points to a cluster of methyltransferases acting on RNA and various proteins, with a central theme of methylation activity. Some outliers (cobalamin biosynthesis, tellurium response) are present but do not override the main pattern. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031167","count":4},{"id":"GO:0018027","count":4},{"id":"GO:0018013","count":3},{"id":"GO:0000183","count":3},{"id":"GO:0018023","count":3}]},{"hash":"1122475010242254641","title":"Embryonic Organogenesis","description":"The GO terms represent development and morphogenesis across many organs (pancreas, pharyngeal system, kidney/ureteric bud, gonads, forebrain neuronal commitment, palate, thyroid, inner ear, uterus), indicating a general embryonic developmental program rather than a single pathway. Confidence: Medium","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0003309","count":2},{"id":"GO:0060037","count":2},{"id":"GO:0072107","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0008584","count":2}]},{"hash":"885807763158873448","title":"Embryonic development and apoptosis signaling","description":"The top GO terms include embryonic development (syncytial blastoderm), heart and hemocyte development, alongside apoptotic and stress-response pathways (extrinsic apoptotic signaling, DNA damage response, responses to staurosporine and hydrogen peroxide). This suggests a cohesive theme of development coupled with programmed cell death and stress signaling.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072734","count":2},{"id":"GO:0001700","count":2},{"id":"GO:0045736","count":2},{"id":"GO:0035234","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1411806540470456687","title":"Embryonic morphogenesis and immune regulation","description":"The top GO terms point to broad embryonic development and tissue morphogenesis across multiple organs (eye, foregut, heart, spinal cord, lymph vessels) along with immune tolerance and regulatory T cell differentiation. This suggests the cluster reflects general developmental programs together with immune regulation rather than a single specific pathway.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043010","count":4},{"id":"GO:0033085","count":4},{"id":"GO:0002513","count":4},{"id":"GO:0048617","count":4},{"id":"GO:0001945","count":4}]},{"hash":"1730966681735956583","title":"Ribosome biogenesis and translation initiation","description":"Dominant GO terms in the cluster center on ribosome assembly and the initiation of translation: small subunit (SSU) biogenesis, maturation of SSU-rRNA, translation reinitiation, and formation of the translation preinitiation complex. These repeatedly observed functions strongly suggest the proteins in this cluster are linked to ribosome assembly and the start of protein synthesis. Some outlier terms (ERAD pathway, apoptosis, insecticide response) appear less representative of the core theme and may reflect broader or misannotated roles. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0000028","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0002109","count":1}]},{"hash":"831289280780850621","title":"Embryonic neural and sensory organ morphogenesis","description":"The terms cluster around early development of brain regions (forebrain, metencephalon, midbrain-hindbrain boundary), sensory organs (eye, inner ear), and craniofacial structures (roof of mouth), plus broader embryonic morphogenesis like somite specification. This points to a cohesive theme of neural and sensory organ development during embryogenesis.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0060021","count":3},{"id":"GO:0022037","count":2},{"id":"GO:0030917","count":2},{"id":"GO:0043010","count":2}]},{"hash":"974036752928283129","title":"Unknown","description":"The top GO terms cover a wide and seemingly unrelated mix of processes (tRNA wobble modification, histidine diphthamide modification, endosomal vesicle fusion, transcription regulation, NF-kB signaling, apoptosis, histone modification/turnover, and X inactivation). With no clear shared function or pathway linking these terms, the proteins appear functionally heterogeneous, so a single cohesive label isn\u2019t evident.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002098","count":1},{"id":"GO:0007117","count":1},{"id":"GO:0017183","count":1},{"id":"GO:0034058","count":1},{"id":"GO:1903721","count":1}]},{"hash":"1326396620582731383","title":"Mitotic cell cycle and kinetochore regulation","description":"This cluster\u2019s GO terms cluster around cell cycle control and mitosis, especially regulation of cyclin-dependent kinase activity and mitotic sister chromatid biorientation, plus kinetochore localization. These indicate proteins involved in regulating mitosis and chromosome segregation, justifying a label focused on mitotic cell cycle regulation.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045736","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0070373","count":1},{"id":"GO:0098783","count":1},{"id":"GO:0043508","count":1}]},{"hash":"2173772057031944489","title":"ER Protein Folding and Quality Control","description":"The cluster is dominated by terms for protein folding in the endoplasmic reticulum, handling of misfolded proteins, ER-associated degradation, and regulation of translation during ER stress, pointing to an ER quality-control/UPR-like theme. A couple of outliers (tRNA import into nucleus and DNA replication) are present, which weakens the link slightly, hence a moderate level of confidence.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035719","count":3},{"id":"GO:1900035","count":3},{"id":"GO:0070843","count":3},{"id":"GO:0034975","count":3},{"id":"GO:0006260","count":3}]},{"hash":"388920036807991883","title":"Autonomic GPCR signaling in heart and vessels","description":"The top GO terms cluster around GPCR signaling and cardiovascular regulation (including positive regulation of GPCR signaling, heart contraction modulation by catecholamines, and vascular smooth muscle contraction), suggesting the proteins participate in autonomic control of heart and blood vessels via GPCR pathways. Some immune-related terms appear, but the dominant theme supports GPCR-driven cardiovascular regulation.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0033861","count":2},{"id":"GO:0031649","count":2},{"id":"GO:2000420","count":2},{"id":"GO:0001997","count":2},{"id":"GO:0045745","count":2}]},{"hash":"391717654608753066","title":"ER protein folding and quality control","description":"The top terms cluster around endoplasmic reticulum maturation and quality-control processes: protein folding in the ER, misfolded protein transport, ER-associated degradation (ERAD), and regulation of protein export from the nucleus. Additionally, ER stress-related translation initiation is represented, consistent with a coordinated ER stress response that upregulates protein folding capacity and quality-control pathways. Some terms (tRNA import into nucleus, DNA replication) appear as sporadic annotations and may reflect incidental associations rather than core function of the cluster.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035719","count":1},{"id":"GO:1900035","count":1},{"id":"GO:0070843","count":1},{"id":"GO:0034975","count":1},{"id":"GO:0006260","count":1}]},{"hash":"217926801668157255","title":"Unknown","description":"The top GO terms are highly diverse, spanning GTPase activity regulation, fertilization, glucose signaling, peroxisome targeting, arginine methylation, rRNA maturation, phagolysosome assembly, forebrain development, cardiac apoptosis, and ubiquitin-related ERAD. With no connecting biological theme and no edges linking proteins, there isn\u2019t a coherent function that defines the cluster. Therefore, the appropriate label is Unknown with no confidence.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0007338","count":2},{"id":"GO:0010255","count":1},{"id":"GO:0006625","count":1},{"id":"GO:0035246","count":1}]},{"hash":"2281690073233677002","title":"Phagocytosis and Antigen Presentation Regulation","description":"The top GO terms cluster around phagocytosis (recognition and engulfment), antigen processing and presentation via MHC II, and aspects of humoral and immunoglobulin-mediated responses, with several terms indicating regulation of these adaptive-immune processes. While a few terms touch on iron homeostasis, the dominant theme is immune defense through phagocytosis and antigen presentation, making this a coherent immune-focused cluster.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006910","count":3},{"id":"GO:0055072","count":2},{"id":"GO:0019731","count":2},{"id":"GO:0045646","count":2},{"id":"GO:0042026","count":2}]},{"hash":"1265220545854741299","title":"Chaperone-Mediated Protein Refolding","description":"This cluster is dominated by GO terms related to chaperone-assisted protein folding and refolding (e.g., protein refolding, chaperone-dependent refolding, and chaperone-mediated protein complex assembly). While a couple terms hint at membrane-associated translocation or pore assembly, the strongest and most frequent signals describe chaperone-driven folding and assembly of protein complexes. This makes \"Chaperone-Mediated Protein Refolding\" a concise and representative label.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051085","count":4},{"id":"GO:0046931","count":4},{"id":"GO:0042026","count":4},{"id":"GO:0044053","count":4},{"id":"GO:0051973","count":4}]},{"hash":"468630559625077571","title":"Ion Channel Regulation","description":"The cluster\u2019s top GO terms cluster around regulation of ion channels and membrane transport, especially voltage-gated calcium channel activity and potassium ion transport across the plasma membrane, suggesting a role in membrane excitability. A couple of terms (heme A biosynthesis, tongue development) appear unrelated and may reflect annotation noise, but the core signal supports ion-channel/membrane transport regulation.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006784","count":1},{"id":"GO:0043586","count":1},{"id":"GO:0086091","count":1},{"id":"GO:0035690","count":1},{"id":"GO:1901387","count":1}]},{"hash":"541317983821438175","title":"Actin cytoskeleton remodeling in neural development","description":"The cluster centers on actin dynamics: multiple terms involve actin polymerization, regulation, and formin-nucleated assembly, plus GTPase activity, all pointing to cytoskeletal remodeling. Additional terms link to neural-specific processes (neural tube closure, synaptic vesicle exocytosis), suggesting a small module coordinating actin-driven remodeling in neural development and related signaling.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030845","count":1},{"id":"GO:0030838","count":1},{"id":"GO:0051497","count":1},{"id":"GO:0043547","count":1},{"id":"GO:2000300","count":1}]},{"hash":"1319464301997325167","title":"Neuronal Development and Signaling","description":"The terms are strongly centered on nervous system development (hippocampus development, nervous system development, negative regulation of axonogenesis) and neural signaling processes (dopamine response, JNK cascade, serine phosphorylation). While a few terms relate to immune signaling, the dominant theme is neuronal development and activity, justifying a neural-biological label.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050771","count":4},{"id":"GO:0043366","count":4},{"id":"GO:0021766","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0033138","count":4}]},{"hash":"2198735772117382451","title":"Unknown","description":"The top GO terms cover vitamin D3 metabolism, sorbitol response, MAPK-related signaling for cell integrity, multiple developmental processes (lung mesenchyme, Schwann cell development, heart valve morphogenesis), apoptotic and toxic substance responses, and even plant-specific abscisic acid signaling, plus an obsolete phosphorylation term. This spread suggests no single, shared function linking all four proteins, indicating the cluster is functionally heterogeneous or not cohesively defining a specific biological module.","confidence":"","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070640","count":4},{"id":"GO:0072709","count":4},{"id":"GO:0000196","count":4},{"id":"GO:0060484","count":4},{"id":"GO:0006915","count":4}]},{"hash":"903224443766022788","title":"Neuronal signaling and synaptic plasticity","description":"The top GO terms point to neuronal communication and synaptic regulation, including positive regulation of exocytosis, synaptic vesicle endocytosis, and ERK/MAPK signaling, along with nervous system development and short-term memory. Together these indicate proteins involved in synaptic vesicle cycling and plasticity, consistent with memory-related neuronal signaling. Skeletal muscle development is present but peripheral to the dominant neuronal themes.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035641","count":3},{"id":"GO:0045921","count":3},{"id":"GO:0070374","count":3},{"id":"GO:1900026","count":3},{"id":"GO:0007399","count":3}]},{"hash":"238622497834893986","title":"Developmental apoptosis and stress response","description":"This cluster centers on programmed cell death and stress signaling. The top GO terms point to apoptotic pathways (staurosporine response, extrinsic apoptotic signaling, ectopic germ cell death, DNA damage response, hydrogen peroxide response) alongside development-related processes (syncytial blastoderm embryonic development, heart development, hemocyte development) and hormone response (estradiol). Taken together, the shared theme is apoptosis and stress responses occurring within developmental contexts. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0072734","count":4},{"id":"GO:0001700","count":4},{"id":"GO:0045736","count":4},{"id":"GO:0035234","count":4},{"id":"GO:0007507","count":4}]},{"hash":"244828484140041621","title":"Energy metabolism and stress response","description":"This cluster shows enrichment for energy-related processes (glycolysis, fatty acid beta-oxidation, valine catabolic) alongside cellular stress/detoxification responses (redox homeostasis, xenobiotic response, insulin signaling). The base-excision repair term is an outlier, but overall the set points to metabolic activity coupled with stress management rather than a single cohesive pathway.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097510","count":1},{"id":"GO:0006284","count":1},{"id":"GO:0032868","count":1},{"id":"GO:0006635","count":1},{"id":"GO:0010124","count":1}]},{"hash":"355486775613030385","title":"DNA damage response and ubiquitin-proteasome regulation","description":"This cluster is dominated by GO terms tying DNA repair and genome maintenance (positive regulation of DNA repair, error-free translesion synthesis, meiotic recombination) with ubiquitin-related processes (free ubiquitin chain polymerization, ubiquitin-dependent ERAD, proteasome localization). The combination suggests coordinated signaling for DNA damage response and targeted protein turnover via the ubiquitin-proteasome system; a few terms related to meiosis/axoneme may reflect genome-maintenance roles in those contexts. Overall, the theme is DNA damage response linked to protein degradation pathways.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0045739","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0010994","count":4},{"id":"GO:0007288","count":4},{"id":"GO:0030433","count":4}]},{"hash":"371468653089208524","title":"Ubiquitin-Proteasome Regulation in Mitosis","description":"Based on the GO terms, the cluster is dominated by ubiquitin-dependent proteolysis (SCF-dependent ubiquitination, K11-linked ubiquitin, ERAD-related ubiquitination) with links to mitotic cell cycle control (G2/M transition) and DNA repair, suggesting a cohesive role in ubiquitin-mediated protein degradation during mitosis and related quality-control pathways. This label captures the central theme while remaining concise and specific.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031146","count":4},{"id":"GO:0070979","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0001701","count":4},{"id":"GO:0000086","count":4}]},{"hash":"212417210188021711","title":"Ubiquitination Regulation and Nuclear Transport","description":"The top GO terms are dominated by ubiquitin-related processes (monoubiquitination, K29-linked ubiquitination, regulation of deubiquitination, and ubiquitin chain activities), with additional terms on regulation of mRNA and tRNA export from the nucleus and autophagy-related protein targeting. This suggests a coherent theme centered on ubiquitin-mediated protein modification coupled with control of nucleocytoplasmic transport, justifying a label that highlights both aspects.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2000238","count":3},{"id":"GO:0010994","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0010793","count":3},{"id":"GO:2000650","count":3}]},{"hash":"1033834787464914702","title":"Diverse Hormone Signaling and Stress Responses","description":"The cluster shows a mix of signaling-related GO terms (auxin signaling, estradiol response, EGF stimulus) along with responses to various stimuli and toxins (arsenic-containing substances, toxic substances, toxin catabolic process) and light-regulated processes. The terms suggest a broad theme of signal transduction and stress/stimulus responses rather than a single precise function, hence a high-level label that captures diverse signaling and stress responses.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009734","count":1},{"id":"GO:0051771","count":1},{"id":"GO:0032355","count":1},{"id":"GO:0014810","count":1},{"id":"GO:0071243","count":1}]},{"hash":"1291363498626681936","title":"Photoreception and circadian light response","description":"The terms cluster around light-related sensing and processing: phototransduction (including UV-A), detection of light for magnetoreception, and entrainment of the circadian clock by light. Additional terms imply light-induced stress or damage responses (photoprotection, singlet oxygen\u2013mediated cell death, DNA damage signaling). Some broader terms like lipid storage and cell cycle may reflect incidental context, but the core theme centers on light perception and circadian regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0006975","count":1},{"id":"GO:0019915","count":1},{"id":"GO:0010117","count":1},{"id":"GO:2000323","count":1}]},{"hash":"659232258142936753","title":"Endothelial differentiation and redox signaling","description":"This cluster centers on endothelial development and vascular processes (endothelial cell development and blood vessel endothelial cell migration) with supporting redox-related activities (cellular oxidant detoxification, responses to hydroperoxide, and oxidative-stress\u2013related anti-apoptotic regulation) and PI3K/AKT signaling. Adipocyte and muscle differentiation terms are present but less representative. Overall, the theme points to vascular development coupled with redox/kinase signaling. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":2},{"id":"GO:0010269","count":1},{"id":"GO:0014902","count":1},{"id":"GO:0051897","count":1},{"id":"GO:0001885","count":1}]},{"hash":"150108606613913916","title":"Nucleotide metabolism and salvage","description":"The proteins are enriched for GO terms related to nucleotide biosynthesis and salvage (CDP, ADP, AMP salvage, ITP/TMP metabolism, and purine ribonucleotide interconversion), indicating a common function in nucleotide metabolism. Some development terms (brain and liver development) appear but seem ancillary to the core metabolic theme.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0046705","count":4},{"id":"GO:0046939","count":4},{"id":"GO:0046940","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0006172","count":4}]},{"hash":"1546762154885718769","title":"Unknown","description":"The top GO terms are highly diverse, including transcriptional regulation by RNA Pol II, leukocyte migration in inflammatory response, several biosynthetic/catabolic pathways, insect defense, and P450-related epoxygenase activity. There is no single unifying function or pathway that ties all four proteins together, and several terms are ancient/obsolete or unrelated to a common cellular role, so a cohesive label is not supported.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0002523","count":2},{"id":"GO:0019260","count":1},{"id":"GO:0009102","count":1},{"id":"GO:0009086","count":1}]},{"hash":"521186706940058660","title":"Innate Immune Defense and Coagulation","description":"The top GO terms cluster around innate immune defense (responses to yeast/fungi, neutrophil-mediated killing, leukocyte migration, defense responses) and hemostasis (blood coagulation, positive regulation of coagulation, plasminogen activation). This points to a shared theme of inflammatory immune response coupled with coagulation processes, with a few terms less central (fractalkine production, Wnt signaling) that may reflect signaling cross-talk. Given the absence of direct interactions in the current edges, the label emphasizes the dominant functional grouping.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0001878","count":2},{"id":"GO:0070946","count":2},{"id":"GO:0010756","count":2},{"id":"GO:0007596","count":2}]},{"hash":"889017929463634013","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009718","count":4},{"id":"GO:0009103","count":3},{"id":"GO:0006556","count":3},{"id":"GO:0042351","count":3},{"id":"GO:0019835","count":3}]},{"hash":"1766412782655522580","title":"Inflammation and development signaling","description":"This cluster shows a concentration of GO terms related to inflammatory responses (response to mechanical stimulus, interleukin-6/IL-8 signaling, NF-kappaB activation, apoptosis) alongside developmental processes (lung and cartilage development, chitin-based cuticle development/ecdysis). The combination suggests proteins involved in immune signaling with developmental contexts; hence the label emphasizes both aspects. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009612","count":2},{"id":"GO:0070741","count":2},{"id":"GO:0030324","count":2},{"id":"GO:0006032","count":2},{"id":"GO:0051216","count":2}]},{"hash":"1311794655670176747","title":"GPCR Signaling Regulation and Cardiovascular Effects","description":"The top GO terms strongly converge on GPCR signaling modulation, including positive regulation of GPCR signaling and serotonin receptor pathways, with downstream effects like adenylate cyclase inhibition and GTPase activity. Several entries also point to cardiovascular-context outcomes (heart contraction, smooth muscle/vascular contraction), suggesting that the cluster reflects coordinated regulation of GPCR-mediated signaling influencing cardiovascular and related neural/immune processes.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":3},{"id":"GO:0031649","count":3},{"id":"GO:2000420","count":3},{"id":"GO:0001997","count":3},{"id":"GO:0045745","count":3}]},{"hash":"525153807012802034","title":"Adhesion-Driven Cytoskeletal and Immune Signaling","description":"This cluster centers on regulation of actin cytoskeleton by cell-cell adhesion, with accompanying immune modulation (NK and T cell processes) and related morphogenesis signals (endothelial, BMP, axon extension), suggesting a shared theme of adhesion cues directing cytoskeletal remodeling and signaling across immune, vascular, and neural contexts.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090138","count":3},{"id":"GO:0002859","count":3},{"id":"GO:0043318","count":3},{"id":"GO:0048675","count":2},{"id":"GO:0097151","count":2}]},{"hash":"431889179956674509","title":"Autophagy-ubiquitin signaling in innate immunity","description":"This cluster is driven by autophagy and ubiquitination terms (including K63-linked ubiquitination) and innate immune responses, with supporting connections to antigen presentation and host-symbiont interactions, pointing to a theme of ubiquitin-mediated autophagic immune regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0043569","count":4},{"id":"GO:0006914","count":4},{"id":"GO:0007014","count":4},{"id":"GO:0045345","count":4},{"id":"GO:2000637","count":4}]},{"hash":"2249167972100538053","title":"Wnt-Driven Developmental Signaling","description":"Top GO terms point to developmental signaling and morphogenesis, notably the Wnt signaling pathway and branching involved in ureteric bud morphogenesis, with osteoblast differentiation regulation supporting differentiation processes. The presence of negative regulation of transcription and DNA binding suggests gene expression control during development, aligning with a development-focused signaling cluster centered on Wnt pathways. ","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032091","count":1},{"id":"GO:0045669","count":1},{"id":"GO:0001658","count":1},{"id":"GO:0043392","count":1},{"id":"GO:0060633","count":1}]},{"hash":"459120048232585345","title":"Peroxisome Biogenesis and Distribution","description":"The GO terms cluster around peroxisome formation and maintenance: membrane biogenesis, import of proteins into peroxisome membrane, ER-dependent peroxisome organization, fission, inheritance, ER exit, and localization processes, indicating proteins involved in constructing and distributing peroxisomes.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016557","count":1},{"id":"GO:0045046","count":1},{"id":"GO:0032581","count":1},{"id":"GO:0072321","count":1},{"id":"GO:0050821","count":1}]},{"hash":"159421430476902150","title":"Immune Regulation and Antiviral Response","description":"The cluster centers on immune system modulation, spanning innate and adaptive responses (innate immune response, dsRNA response, B cell activation/proliferation, regulation of T cell differentiation, and T-helper 2 cytokine production), antiviral activity (negative regulation of viral genome replication), and inflammatory regulation (cellular response to dexamethasone) with coagulation-linked inflammation, indicating a cohesive theme of immune regulation and antiviral defense.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045581","count":4},{"id":"GO:0045071","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0042100","count":4},{"id":"GO:2000552","count":4}]},{"hash":"1126817217086158515","title":"Neuronal development and dendrite morphogenesis","description":"Most top GO terms cluster around nervous system development and neurite formation (dendrite morphogenesis, hippocampus development, nervous system development, axonogenesis-related terms) with supporting signaling and cytoskeletal processes (JNK signaling, serine phosphorylation, stress fiber assembly) that are typical of neurite outgrowth and maturation. Although one term relates to beta selection, the dominant theme is neuronal development and dendritic/axonal morphogenesis, suggesting the proteins function together in shaping neuronal processes.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0050771","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0043366","count":3}]},{"hash":"2189458091614942925","title":"Developmental ubiquitin-proteasome turnover","description":"The top GO terms point to neural tube closure and multicellular organism development, along with SCF-dependent ubiquitin-proteasomal protein degradation and protein polyubiquitination, suggesting the cluster reflects developmentally regulated proteolysis. A few peripheral terms exist (cadmium response, glucose signaling, peroxisome targeting, rRNA maturation) but do not negate the main theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001843","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0071276","count":2}]},{"hash":"1266655078292604783","title":"B cell receptor signaling and ubiquitin-mediated regulation","description":"These terms converge on immune signaling, especially adaptive immunity and B cell receptor signaling, with ubiquitin-mediated protein turnover. The presence of ubiquitination and regulatory pathways linked to NF-\u03baB, ERK cascades, and apoptosis suggests a module where ubiquitin dynamics modulate signaling outcomes in B cells.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0042993","count":2}]},{"hash":"658548814420887576","title":"Mitochondrial fission and membrane remodeling","description":"The GO terms are dominated by mitochondrial fission, membrane organization/remodeling, and related cell death processes (apoptosis and necroptosis), with peroxisome fission also appearing. This points to a cohesive theme of organelle division and membrane dynamics linked to cell death signaling; the sensory perception of sound term is likely an annotation anomaly and does not change the overall interpretation.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0070584","count":2},{"id":"GO:0060988","count":2},{"id":"GO:0000266","count":2},{"id":"GO:0006915","count":2}]},{"hash":"770395980946565293","title":"Hair keratinization","description":"The GO terms point to keratinization and hair cycle, suggesting proteins involved in hair shaft formation and keratin filament assembly, indicating a cohesive hair-related keratinization cluster.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":4},{"id":"GO:0042633","count":4}]},{"hash":"1777582721134976425","title":"Immune-vascular development and EMT","description":"This cluster shows strong signals for innate immunity and complement activation, along with angiogenesis, endothelial proliferation, and epithelial-to-mesenchymal transition, plus developmental signals (spinal cord/somite) and lipid metabolism terms. The GO terms collectively suggest proteins involved in immune-related vascular remodeling during development and tissue remodeling, rather than a single specific function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0021510","count":3},{"id":"GO:0001935","count":3},{"id":"GO:0006883","count":3}]},{"hash":"633531230500991249","title":"SNARE-Mediated Synaptic Vesicle Trafficking","description":"Intense presence of vesicle fusion, SNARE complex assembly, intra-Golgi transport, and neurotransmitter secretion/receptor localization to synapse points to a function in SNARE-driven vesicle trafficking and exocytosis at the synapse.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":"vesicle-mediated transport","top_go_terms":[{"id":"GO:1903078","count":3},{"id":"GO:0006675","count":3},{"id":"GO:1904050","count":3},{"id":"GO:0051469","count":3},{"id":"GO:0048280","count":3}]},{"hash":"1569637160559841005","title":"GPCR-Mediated Cardiovascular Signaling","description":"These proteins show strong GO terms for GPCR signaling regulation, including positive regulation of GPCR signaling, serotonin receptor pathways, and epinephrine/norepinephrine\u2013driven heart contraction, as well as vascular smooth muscle contraction. While a few terms touch on immune and neural processes (e.g., dendritic cell chemotaxis, dopamine secretion), the dominant pattern is GPCR-driven modulation of cardiovascular function, supporting this label as representative. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":4},{"id":"GO:0031649","count":4},{"id":"GO:2000420","count":4},{"id":"GO:0001997","count":4},{"id":"GO:0045745","count":4}]},{"hash":"142969038826416017","title":"Ion transport and cation homeostasis","description":"The cluster is dominated by GO terms for transmembrane transport of monoatomic cations (including calcium, potassium, zinc) and related ion homeostasis (sodium), suggesting a core function in ion transport and maintenance of cellular ion balance, despite a few unrelated terms that may reflect broad annotations. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033574","count":4},{"id":"GO:0021650","count":4},{"id":"GO:0009103","count":4},{"id":"GO:0006883","count":4},{"id":"GO:0031448","count":4}]},{"hash":"1083899178631199102","title":"Skeletal muscle function and ion homeostasis","description":"This cluster shows a coherent signal around skeletal muscle physiology and energy/ion regulation: regulation of muscle contraction and relaxation, fast/slow fiber transitions, ATP biosynthesis, and ion homeostasis (Na+, K+, Mn). There are a few outlier terms (nerve formation, hormonal response) that introduce some noise, but the dominant theme points to muscle function and cellular energetics. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030026","count":3},{"id":"GO:0021650","count":3},{"id":"GO:0045988","count":3},{"id":"GO:0090076","count":3},{"id":"GO:0033574","count":3}]},{"hash":"2210587012621126648","title":"GPCR-Mediated Cardiovascular and Neural Signaling","description":"The cluster's top GO terms center on GPCR signaling regulation and downstream effects such as heart contraction, vascular smooth muscle activity, serotonin/dopamine signaling, and dendritic cell chemotaxis, pointing to a shared theme of GPCR-driven communication across cardiovascular, neural, and immune contexts.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":4},{"id":"GO:0031649","count":4},{"id":"GO:2000420","count":4},{"id":"GO:0001997","count":4},{"id":"GO:0045745","count":4}]},{"hash":"2066950340179868728","title":"Autonomic GPCR Signaling and Cardiac Regulation","description":"The top GO terms emphasize GPCR signaling regulation, modulation of heart contraction by catecholamines, smooth muscle contraction, and related signaling pathways, with additional notes on dopamine secretion and dendritic cell chemotaxis. The strongest shared theme is GPCR-mediated signaling impacting cardiovascular and smooth muscle function, with possible neuromodulatory contributions, making this label representative of the cluster\u2019s likely function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033861","count":1},{"id":"GO:0031649","count":1},{"id":"GO:2000420","count":1},{"id":"GO:0001997","count":1},{"id":"GO:0045745","count":1}]},{"hash":"1690314510987320258","title":"Calcium signaling and innate immune defense","description":"This cluster is driven by terms linking intracellular calcium signaling with innate immune responses, including defense against Gram-positive/Gram-negative bacteria and cellular response to LPS. While there are also some bone/myelination terms present, the core theme appears to be calcium-dependent signaling connected to antibacterial defense, giving a coherent, high-level label.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035584","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0045087","count":2}]},{"hash":"757150434549285162","title":"Inflammation-driven angiogenesis and ECM remodeling","description":"This cluster combines inflammatory signals (response to lipopolysaccharide, inflammatory response) with extracellular matrix dynamics (hyaluronan biosynthesis, cell-matrix adhesion) and sprouting angiogenesis (positive regulation of endothelial proliferation in sprouting angiogenesis, cell migration), reflecting tissue remodeling where immune cues promote vascular growth and mechanical cues influence remodeling.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032496","count":3},{"id":"GO:0006954","count":3},{"id":"GO:1900127","count":3},{"id":"GO:1903588","count":3},{"id":"GO:0007275","count":3}]},{"hash":"2207151126060388193","title":"Glycan biosynthesis and ECM remodeling","description":"The top GO terms revolve around glycosylation and glycan biosynthesis (keratan sulfate proteoglycan, glycosphingolipid, protein glycosylation) and extracellular matrix/cell-matrix interactions (wound healing, epithelial proliferation, fibroblast regulation), with some reproduction-related terms (zona pellucida binding) reflecting ECM interactions rather than a single pathway.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":2},{"id":"GO:0008542","count":1},{"id":"GO:0018146","count":1},{"id":"GO:0002526","count":1},{"id":"GO:0048147","count":1}]},{"hash":"1671466084382994628","title":"Spliceosome Assembly and mRNA Splicing","description":"The dominant GO terms are spliceosomal snRNP assembly and mRNA cis splicing via spliceosome, pointing to core RNA processing. Other immune-response terms are incidental and less informative. Therefore, the cluster most likely groups proteins involved in spliceosome assembly and mRNA splicing.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000387","count":2},{"id":"GO:0071222","count":1},{"id":"GO:0008595","count":1},{"id":"GO:0045292","count":1},{"id":"GO:0034122","count":1}]},{"hash":"2252724488263357493","title":"LPS/TLR-Triggered Inflammatory NF-\u03baB Signaling","description":"The GO terms point to innate immune sensing of lipopolysaccharide (LPS), TLR/GPCR\u2013related signaling, and activation of inflammatory and NF-\u03baB pathways, along with antiviral defense. This pattern suggests a cohesive cluster of proteins involved in endotoxin-driven inflammatory responses and NF-\u03baB\u2013mediated signaling, with a potential note on angiogenesis regulation within inflammatory contexts.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":4},{"id":"GO:0042346","count":4},{"id":"GO:0070100","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0031663","count":4}]},{"hash":"1121927336255826417","title":"Neuronal development and mitochondrial respiration","description":"This cluster includes multiple brain-region and neuron development terms (thalamus, subthalamus, hippocampus, midbrain, pons, pyramidal neuron development, cerebellar Purkinje cell layer development) alongside mitochondrial energy metabolism terms (mitochondrial electron transport, proton transmembrane transport, aerobic respiration), suggesting a link between neuronal development processes and mitochondrial function in these proteins.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006122","count":1},{"id":"GO:0021794","count":1},{"id":"GO:1902600","count":1},{"id":"GO:0009060","count":1},{"id":"GO:0021539","count":1}]},{"hash":"198458836734838851","title":"Unknown","description":"The GO terms span proteolysis and collagen breakdown, protein maturation, chromatin organization, various immune signaling and cell proliferation processes, and even unrelated obsolete terms, with no single cohesive function or pathway linking the proteins and no observed interactions. Therefore, there is no clear theme to assign a specific label.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030574","count":1},{"id":"GO:0006508","count":1},{"id":"GO:0035551","count":1},{"id":"GO:0034396","count":1},{"id":"GO:0003094","count":1}]},{"hash":"2013490333176633734","title":"Unknown","description":"This cluster includes telomere capping and telomerase maintenance terms, a protein ubiquitination term, and disparate terms related to heart development/conduction and thermoception, without a single cohesive biological theme. The mixed functions suggest no clear common function tying the proteins together, so Unknown with None confidence is appropriate. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904355","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0032212","count":2},{"id":"GO:0044707","count":1},{"id":"GO:2000340","count":1}]},{"hash":"1990045771499787129","title":"Unknown","description":"These four proteins are annotated with a wide spread of GO terms, including vitamin D3 metabolic process, cellular response to sorbitol, MAPK cascade, various developmental processes (lung-associated mesenchyme, Schwann cell development, tricuspid valve morphogenesis), apoptotic process, and general stress responses. There is no clear, shared biological process or molecular function linking them, and there are no interaction edges among the proteins in this cluster. Therefore, no single cohesive theme emerges.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070640","count":2},{"id":"GO:0072709","count":2},{"id":"GO:0000196","count":2},{"id":"GO:0060484","count":2},{"id":"GO:0006915","count":2}]},{"hash":"2089941732311610554","title":"Cardiac development and adrenergic signaling","description":"This cluster shows strong signals for heart development, regulation of heart contraction by epinephrine/norepinephrine, vascular smooth muscle contraction, and GPCR signaling, indicating a cardiovascular function-centric group despite a few immune-related terms.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0090026","count":3},{"id":"GO:0033861","count":2},{"id":"GO:0031649","count":2},{"id":"GO:2000420","count":2}]},{"hash":"828688755511096932","title":"Ubiquitination and NF-kappaB signaling","description":"The GO terms point to multiple ubiquitin linkage types (K48, K63, K6), ubiquitin-dependent proteolysis/autoubiquitination, and related processes like histone catabolic turnover, all tied to modulation of inflammatory signaling pathways such as canonical NF-kappaB and TNF signaling, forming a coherent ubiquitination-focused cluster.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0070936","count":3},{"id":"GO:0036205","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0085020","count":3},{"id":"GO:0043123","count":3}]},{"hash":"1521338782018468074","title":"Craniofacial and cardiac morphogenesis","description":"These proteins are annotated with GO terms tied to embryonic development of craniofacial structures (cartilage morphogenesis, roof of mouth development) and heart morphogenesis (epithelial to mesenchymal transition in endocardial cushion formation, left/right pattern formation), suggesting a neural crest\u2013driven craniofacial and cardiac development theme. Some terms (transcription regulation, ribosomal export) appear more general and may reflect background cellular processes rather than core function of the cluster.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0007576","count":2}]},{"hash":"312305490209012286","title":"Bacterial envelope biosynthesis and stress response","description":"Top GO terms include lipopolysaccharide biosynthetic process and transmembrane transport, alongside arsenic detox and response, iron-sulfur cluster assembly, and regulatory phosphorylation events. This pattern best fits a cluster of proteins tied to bacterial envelope maintenance and chemical/metal stress responses, rather than a single isolated function. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0099133","count":3},{"id":"GO:1990507","count":3},{"id":"GO:0009103","count":3},{"id":"GO:0071722","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1396107316544921217","title":"GPCR signaling and cardiovascular regulation","description":"The top GO terms point to G protein-coupled receptor signaling and downstream cardiovascular effects, including vascular smooth muscle contraction and heart contraction regulation (and related GPCR pathways). Additional terms touch on locomotion and immune cell movement, which can reflect broader GPCR-mediated signaling roles. Taken together, the cluster seems to reflect a GPCR-centric signaling module influencing cardiovascular/muscle function and related processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007626","count":4},{"id":"GO:0033861","count":3},{"id":"GO:0031649","count":3},{"id":"GO:2000420","count":3},{"id":"GO:0001997","count":3}]},{"hash":"851263216930227966","title":"Neurohormonal GPCR signaling and cardiovascular regulation","description":"The top terms cluster around GPCR-mediated signaling involved in heart and vascular function (positive regulation of heart contraction by adrenaline/noradrenaline, vascular smooth muscle contraction, GPCR signaling), along with related neurotransmitter pathways (serotonin, dopamine) and broader neurohormonal signaling. Some immune-related terms (dendritic cell chemotaxis, eosinophil regulation) appear as peripheral associations, but the core theme is neurohormonal GPCR control of cardiovascular and vascular processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033861","count":2},{"id":"GO:0031649","count":2},{"id":"GO:2000420","count":2},{"id":"GO:0001997","count":2},{"id":"GO:0045745","count":2}]},{"hash":"2074144354457983519","title":"Synaptic Regulation and Mitochondrial Dynamics","description":"The top GO terms cluster around modulation of neuronal signaling (inhibiting excitatory postsynaptic potential, reducing spontaneous neurotransmitter release, dopamine uptake) along with mitochondrial fission and its regulation, plus ubiquitination processes. This suggests a functional theme of controlling synaptic activity with links to mitochondrial dynamics and protein turnover in neurons.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045216","count":2},{"id":"GO:0046329","count":1},{"id":"GO:0000266","count":1},{"id":"GO:0090394","count":1},{"id":"GO:0090258","count":1}]},{"hash":"1421617827440520200","title":"Planar Polarity in Tissue Morphogenesis","description":"The GO terms cluster around planar cell polarity (GO:0090251), cell adhesion (GO:0007156/7), receptor clustering, and morphogenesis processes such as lung branching morphogenesis and gastrulation epiboly, plus axon guidance. The common theme is planar polarity\u2013driven organization guiding tissue morphogenesis, with adhesion and receptor clustering as supporting mechanisms. Hence the label Planar Polarity in Tissue Morphogenesis.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":3},{"id":"GO:0048105","count":2},{"id":"GO:0055113","count":2},{"id":"GO:0060490","count":2},{"id":"GO:0043113","count":2}]},{"hash":"1834137738693071158","title":"Integrin-Mediated Adhesion and ECM Signaling","description":"The cluster\u2019s top GO terms are dominated by integrin-mediated signaling, cell\u2013matrix and cell\u2013cell adhesion, and collagen/fibril organization, indicating a central role in ECM interactions and adhesion-driven signaling. Additional terms touch on related developmental and nervous system processes (Notch processing, myelination in PNS, AMPA receptor activity) suggesting a broader, tissue-structuring signaling context rather than a single pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022011","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0010042","count":3},{"id":"GO:0007220","count":3},{"id":"GO:0034612","count":3}]},{"hash":"2060421816795390616","title":"Growth Factor Signaling and Cell Adhesion","description":"The cluster\u2019s top GO terms point to broad signaling pathways triggered by growth factors (EGF stimulus, insulin receptor signaling) and processes linked to cell adhesion and motility (integrin activation, fibroblast migration). Additional terms touch on metabolism (glycogen biosynthesis) and muscle-related activity (cardiac contraction) as well as vesicle trafficking and mitochondrial changes, suggesting a general theme of signaling-driven regulation of cellular behavior rather than a single specialized pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045725","count":2},{"id":"GO:0030259","count":2},{"id":"GO:0008637","count":2},{"id":"GO:0071364","count":2},{"id":"GO:0033622","count":2}]},{"hash":"2294212714318453298","title":"Cell signaling and adhesion dynamics","description":"The GO terms cluster around signaling pathways (ERK cascade, calcium signaling, phosphatase activity regulation) and cell adhesion/migration processes (cell-matrix adhesion, leukocyte tethering, ameboid movement). While there are developmental and neural-related terms, the strongest shared theme is signaling linked to adhesion and movement, justifying a label focused on signaling-adhesion dynamics.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900363","count":2},{"id":"GO:0032516","count":1},{"id":"GO:0033690","count":1},{"id":"GO:0003366","count":1},{"id":"GO:0070371","count":1}]},{"hash":"350404030863932355","title":"Zinc Transport and Homeostasis","description":"Based on the GO terms, the dominant theme is zinc handling: import across the plasma membrane, intracellular zinc ion homeostasis, detoxification, and related metal transport (including cadmium). A couple of terms (limb development, tight junction assembly) are incidental and do not define the cluster\u2019s primary function. Thus, the core label highlights zinc transport and homeostasis.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060173","count":1},{"id":"GO:1903615","count":1},{"id":"GO:0006830","count":1},{"id":"GO:0006831","count":1},{"id":"GO:0006882","count":1}]},{"hash":"1498095134009709824","title":"Immune suppression and cell adhesion","description":"The top GO terms are dominated by negative regulation of immune cell activities (NK cell cytotoxicity, macrophage activation, and CTL degranulation) and by heterophilic/cell\u2013cell adhesion, suggesting a theme of dampening immune responses and mediating cell interactions. Other terms (autophagy of peroxisome, transport) are less central to the core theme. Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002859","count":2},{"id":"GO:0086072","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0043031","count":2},{"id":"GO:0043318","count":2}]},{"hash":"1798468736210487135","title":"Unknown","description":"The top GO terms are extremely diverse, including memory (short-term and long-term), several signaling pathways (calcineurin\u2013NFAT, GTPase regulation), cell shape changes (EMT), VEGF signaling, and even bioluminescence. This lack of a single cohesive biological theme suggests no clear, common function binding these proteins, so the cluster is best labeled Unknown with no confidence.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007614","count":3},{"id":"GO:0051533","count":3},{"id":"GO:0008360","count":3},{"id":"GO:0008218","count":3},{"id":"GO:0007616","count":3}]},{"hash":"462432098571573982","title":"Unknown","description":"The top GO terms span very diverse biological processes, including neural development (axonogenesis, motor neuron specification), reproductive tract development, plant seed morphogenesis, miRNA silencing regulation, T cell homeostasis, and endocytic recycling. There isn\u2019t a single coherent function or pathway connecting these terms across the proteins, so a specific functional label isn\u2019t justifiable.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048936","count":3},{"id":"GO:0035852","count":3},{"id":"GO:0045856","count":3},{"id":"GO:0021520","count":3},{"id":"GO:0048317","count":3}]},{"hash":"145115477156712387","title":"NF-kappaB pathway regulators","description":"This cluster's GO terms center on regulation of NF-kappaB signaling (I-kappaB phosphorylation, non-canonical NF-kappaB signaling, and related transcriptional regulation) and immune functions (spleen development, T-helper cell differentiation), suggesting proteins that modulate NF-kappaB pathways and immune responses. Some terms are less directly related, but the NF-kappaB theme is dominant.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046621","count":1},{"id":"GO:1903721","count":1},{"id":"GO:0032487","count":1},{"id":"GO:0060816","count":1},{"id":"GO:0030433","count":1}]},{"hash":"1247810157930606860","title":"Small-Molecule Catabolism","description":"The top GO terms point to multiple catabolic pathways for small molecules, including sorbitol, xylitol, ethanol, and related processes (pyruvate fermentation to ethanol, fatty acid omega-oxidation, retinol metabolism). This suggests the proteins in the cluster mainly participate in breakdown of diverse small molecules for energy or detoxification, despite a few terms related to immune or respiratory responses that may reflect broader cellular contexts. Overall, the cohesive theme is metabolic catabolism of small molecules.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006062","count":2},{"id":"GO:0097327","count":2},{"id":"GO:0051160","count":2},{"id":"GO:0010430","count":2},{"id":"GO:0019518","count":2}]},{"hash":"1078771701107735238","title":"Ciliogenesis and cellular stress responses","description":"The cluster centers on ciliogenesis-related terms such as intraflagellar transport and non-motile cilium assembly, with supporting GO terms for ER-to-Golgi vesicle transport, which together point to ciliary biogenesis. Autophagy and apoptotic processes suggest cellular stress or fate decisions within these cells. While there are other developmental terms (neurogenesis, chaeta development) that are less directly linked to ciliogenesis, they may reflect broader developmental roles in this gene set, yielding a reasonable but not tightly unified theme.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006914","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0022008","count":2},{"id":"GO:0019886","count":2},{"id":"GO:0022416","count":2}]},{"hash":"1729964508253924137","title":"JAK-STAT cytokine signaling and antiviral defense","description":"This cluster centers on immune signaling: positive regulation of STAT phosphorylation, cytokine-mediated signaling, IL-10 production, and defense response to virus, all pointing to a JAK-STAT\u2013driven cytokine signaling module. Some developmental terms appear but are less central to the dominant immune-related functions.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042517","count":3},{"id":"GO:0019221","count":2},{"id":"GO:0032733","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0007169","count":2}]},{"hash":"1931528279104894137","title":"Unknown","description":"The top GO terms span ribosome biogenesis, ER stress and degradation pathways, neuronal development, immune signaling, insecticide response, and embryonic cell cycle, with no single cohesive function or pathway linking all three proteins. This suggests no clear common theme for the cluster.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002109","count":3},{"id":"GO:1902236","count":3},{"id":"GO:0048936","count":3},{"id":"GO:1903265","count":3},{"id":"GO:0030433","count":3}]},{"hash":"1600031559914207520","title":"Multisystem Developmental Differentiation","description":"These proteins are associated with a range of developmental processes across tissues and lineages, including mesodermal differentiation, spinal cord development/patterning, bone formation (osteoblast proliferation), and various immune and neural differentiation events (T cell differentiation/chemotaxis, macrophage fusion, peripheral nervous system axon regeneration). No single coherent pathway emerges, suggesting a general role in multisystem development. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033089","count":1},{"id":"GO:0033690","count":1},{"id":"GO:0034241","count":1},{"id":"GO:0031659","count":1},{"id":"GO:0003366","count":1}]},{"hash":"2252169865878124614","title":"Ribosome biogenesis and ER quality control","description":"The terms cluster around ribosome assembly (maturation of SSU-rRNA and translation) and ER-related protein quality control (ERAD, unfolded protein maintenance, proteasomal regulation) as well as ER stress signaling, suggesting a common theme of coordinating protein synthesis with ER homeostasis. Some terms are obsolete or less directly related (neuron development, insecticide response), likely reflecting annotation noise.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002109","count":3},{"id":"GO:1902236","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0021888","count":3},{"id":"GO:0017085","count":3}]},{"hash":"1587298338289224532","title":"Embryonic morphogenesis and patterning","description":"These GO terms cluster around developmental morphogenesis and axis/pattern formation across multiple tissues (cartilage, brain corpus callosum, heart endocardial cushion EMT, left-right patterning, melanocyte migration/pigmentation, and thymic differentiation). The shared theme is embryonic development and tissue morphogenesis rather than a single molecular function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021540","count":2},{"id":"GO:0003198","count":2},{"id":"GO:1903056","count":2},{"id":"GO:0060030","count":2},{"id":"GO:0033081","count":2}]},{"hash":"1993093485242935596","title":"Flowering Regulation and Inflorescence Development","description":"The top GO terms cluster around flower development, inflorescence development, regulation and timing of flowering, and photoperiodic flowering, indicating a shared role in controlling the switch to reproductive growth and floral formation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009908","count":1},{"id":"GO:0010229","count":1},{"id":"GO:0009910","count":1},{"id":"GO:0030154","count":1},{"id":"GO:0007275","count":1}]},{"hash":"192636931959225078","title":"Ubiquitin-Dependent NF-\u03baB Signaling and Proteostasis","description":"This cluster centers on ubiquitin-mediated regulation, with strong signals for ubiquitin-dependent degradation pathways (ERAD and K48-linked ubiquitination) and NF-\u03baB signaling components (NIK activation and I\u03baB phosphorylation). The presence of histone-related and X-chromosome dosage terms likely reflects overlapping ubiquitin/chromatin regulatory machinery or annotation noise, but the dominant theme is ubiquitin-proteasome control of signaling and protein turnover, including NF-\u03baB pathway activation. ","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0046621","count":2},{"id":"GO:1903721","count":2},{"id":"GO:0060816","count":2},{"id":"GO:0009048","count":2}]},{"hash":"457978060964428356","title":"Drosophila embryogenesis and axis patterning","description":"These terms cluster around early embryonic development and body-axis specification, including rostrocaudal neural patterning, anterior/posterior axis specification, and segmentation-related processes like the syncytial blastoderm mitotic cycle and sex comb development. The mix of development, patterning, and transcriptional regulation (e.g., negative regulation of transcription, histone modification) fits a coordinated developmental program in Drosophila, suggesting these proteins participate in embryogenesis and axis formation.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021903","count":3},{"id":"GO:0048103","count":3},{"id":"GO:0009948","count":3},{"id":"GO:1903721","count":3},{"id":"GO:0009048","count":3}]},{"hash":"1074421601528937560","title":"Post-transcriptional mRNA processing","description":"GO terms here cluster around mRNA maturation and processing events, including spliceosome-mediated splicing (and its regulation and splice-site recognition), polyadenylation, mRNA export, various mRNA modifications, and even translation reinitiation. This points to a cohesive role in post-transcriptional regulation of gene expression and mRNA maturation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":2},{"id":"GO:0006406","count":1},{"id":"GO:0000380","count":1},{"id":"GO:0060211","count":1},{"id":"GO:0045292","count":1}]},{"hash":"1404985344530809459","title":"RTK signaling in neural and vascular development","description":"The top GO terms center on cell surface receptor protein tyrosine kinase signaling, indicating RTK-mediated signaling. They also cover neural development (dendrite regulation, axon regeneration) and vascular/mesenchymal differentiation (pericyte differentiation, nephric duct morphogenesis, etc.), suggesting a theme of developmental signaling guiding neural and vascular differentiation via RTK pathways.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007169","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0050773","count":2},{"id":"GO:0072178","count":2},{"id":"GO:0070106","count":2}]},{"hash":"2248992204396028896","title":"Dendritic cell activation and phagocytosis","description":"The GO terms emphasize innate immune signaling (innate immune response-activating signaling pathway), dendritic cell chemotaxis, and positive regulation of phagocytosis, along with related processes like cell adhesion/migration and senescence. Together these suggest a functional cluster centered on dendritic cell activation and phagocytic function, with some peripheral terms (hormone receptor signaling, zona pellucida binding) that may reflect pleiotropic or multi-function proteins.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0033144","count":3},{"id":"GO:1900026","count":3},{"id":"GO:0048387","count":2},{"id":"GO:2000510","count":2},{"id":"GO:0007339","count":2}]},{"hash":"641982876289236570","title":"Actin Cytoskeleton Remodeling","description":"This cluster is dominated by GO terms relating to actin dynamics and cell protrusions, including positive regulation of filopodium and lamellipodium assembly and actin filament capping, plus dendrite extension and related neurite outgrowth. The combination suggests a theme of actin-based remodeling and protrusive activity rather than stable cytoskeletal structures like stress fibers. The somite specification term is a developmental context, but the shared function across members appears to be modulation of actin-based protrusions and cell movement.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051491","count":1},{"id":"GO:0051016","count":1},{"id":"GO:0010592","count":1},{"id":"GO:0001757","count":1},{"id":"GO:0051497","count":1}]},{"hash":"1353596314204616192","title":"Unknown","description":"The GO terms are highly diverse (interleukin-2 production regulation, vitamin D3 metabolism, sorbitol response, MAPK cascade, mesenchyme and Schwann cell development, apoptosis, glycogen biosynthesis, abscisic acid signaling, and more), with no single clear shared function tying the proteins together. This suggests no coherent theme for a specific, representative label.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045086","count":3},{"id":"GO:0070640","count":3},{"id":"GO:0072709","count":3},{"id":"GO:0000196","count":3},{"id":"GO:0060484","count":3}]},{"hash":"1918658834704090050","title":"RNA processing and transcription regulation","description":"This cluster centers on RNA metabolism and transcription control, with GO terms for rRNA maturation (SSU/LSU), mRNA export, transcription initiation and start-site regulation, and transcription-coupled repair. While there is a spread to immune RNA sensing (MDA-5), the dominant theme ties to RNA maturation and transcription regulation.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006311","count":3},{"id":"GO:0016973","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0014070","count":3},{"id":"GO:0006283","count":3}]},{"hash":"1346246453669472407","title":"Ubiquitin-Dependent Signaling and Apoptosis","description":"Top terms point to Hippo signaling, regulation of insulin receptor signaling, dephosphorylation, and apoptotic processes, with additional emphasis on ubiquitin-related activities (free ubiquitin chains, ERAD) and DNA damage response. This suggests a network where ubiquitin-mediated regulation modulates diverse signaling pathways that control cell survival, metabolism, and stress responses, including apoptosis and cardiac/neural maintenance. The cluster thus appears to represent ubiquitin-dependent regulation of signaling and cell fate, rather than a single highly specific pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035329","count":2},{"id":"GO:0046626","count":1},{"id":"GO:0016311","count":1},{"id":"GO:0006915","count":1},{"id":"GO:0010994","count":1}]},{"hash":"899126680890014778","title":"GPCR-cAMP Signaling and Membrane Trafficking","description":"The terms point to signaling at the cell surface (GPCR, cAMP/PKA, cGMP-related responses) together with membrane-associated processes (endocytic recycling, localization to cell junctions) and structural aspects like microvillus assembly. This suggests a theme of membrane signaling coupled with trafficking rather than a single isolated pathway, hence a membrane-signaling/trafficking cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030033","count":2},{"id":"GO:0032486","count":1},{"id":"GO:0071321","count":1},{"id":"GO:0071880","count":1},{"id":"GO:1901223","count":1}]},{"hash":"411398750773058308","title":"Unknown","description":"The top GO terms are spread across diverse, tissue-specific developmental processes (tracheal system, mammary gland, heart valve formation, ectodermal fate, NK T cell proliferation) and general regulatory activities (miRNA transcription), with no shared function or pathway linking the proteins. There are no interactions (edges) connecting these proteins, so there isn\u2019t a cohesive theme to label beyond \u201cunknown.\u201d","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035155","count":3},{"id":"GO:0033600","count":3},{"id":"GO:0003199","count":3},{"id":"GO:0001712","count":3},{"id":"GO:0045653","count":3}]},{"hash":"1611432142724564885","title":"Developmental morphogenesis","description":"The top GO terms point to morphogenesis and development across multiple tissues and organs (embryonic hindlimb, eye, heart, placenta, gonads, brain regions, etc.), suggesting the proteins cluster around general developmental processes rather than a single pathway. A concise label that captures this shared theme is Developmental morphogenesis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035116","count":3},{"id":"GO:0021986","count":3},{"id":"GO:0048048","count":3},{"id":"GO:0003148","count":3},{"id":"GO:0008584","count":3}]},{"hash":"2076184298752016388","title":"Unknown","description":"The top terms include nuclear export (tRNA and mRNA), ubiquitination (monoubiquitination and K29-linked), and autophagy/mitophagy, plus some unrelated signaling terms, indicating a mix of disparate processes with no single cohesive function. Consequently, there is no clear theme to name the cluster beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000238","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0010793","count":2},{"id":"GO:2000650","count":2},{"id":"GO:0035519","count":2}]},{"hash":"242362606414819013","title":"Flavonoid Biosynthesis and Glucuronidation","description":"GO terms point to flavonoid-related metabolism, including anthocyanin-containing compound biosynthesis and glucuronidation of flavonoids/xenobiotics, plus associated carbohydrate and glycolipid biosynthesis. This suggests a cluster centered on plant secondary metabolism and detoxification pathways, though a couple terms (cell shape regulation, paranode localization) may reflect annotation noise or broader functional links.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0052696","count":2},{"id":"GO:0008360","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0009718","count":2},{"id":"GO:0002175","count":2}]},{"hash":"2023564852378287444","title":"Unknown","description":"The GO terms include blood coagulation, complement activation, collagen catabolic process, and several developmental/transcription-regulation processes, but there is no single, cohesive function linking these proteins, and the cluster has no edges, indicating a mixed set rather than a specific module.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0030574","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0001867","count":2}]},{"hash":"1644230424772353549","title":"Biosynthesis and Metabolism","description":"Top GO terms indicate a mix of biosynthetic and metabolic processes (amino acid, lipid, one-carbon, and secondary metabolite biosynthesis) and a photosynthetic pathway term, suggesting a broad metabolic theme. The absence of network edges and the presence of an outlier term (host cell entry) imply the connection is not cohesive to a single pathway, so the label is a best-effort broad categorization.","confidence":"Low","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0009718","count":2},{"id":"GO:0001887","count":1},{"id":"GO:0009854","count":1},{"id":"GO:0006564","count":1}]},{"hash":"2030392642104804799","title":"Redox detoxification and toxin response","description":"The GO terms show a strong emphasis on cellular oxidant detoxification and redox homeostasis, with multiple terms related to response to toxic substances, arsenic-containing substances, and toxin catabolic processes. While there are ancillary signals related to calcium signaling and starvation, the dominant theme is detoxification and oxidative stress response, which best defines the cluster's function.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0045454","count":3},{"id":"GO:0014810","count":2},{"id":"GO:0071243","count":2},{"id":"GO:0051726","count":2}]},{"hash":"1300200248755376353","title":"Nucleotide Biosynthesis and Salvage","description":"The top GO terms cluster around nucleotide metabolism (CDP/ADP/AMP/GTP/ITP biosynthesis and interconversion, and nucleoside monophosphate phosphorylation), indicating a shared function in nucleotide production and salvage; brain and liver development annotations are likely incidental.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046705","count":3},{"id":"GO:0046939","count":3},{"id":"GO:0046940","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0006172","count":3}]},{"hash":"737257599444821615","title":"Embryonic brain and sensory organ development","description":"The GO terms cohere around embryonic development involving neural and sensory structures\u2014forebrain development, metencephalon and midbrain-hindbrain boundary development\u2014along with organogenesis of the eye and inner ear, palate, and other morphogenetic processes. This suggests a common theme of early developmental patterning and formation of brain and sensory organs.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0022037","count":1},{"id":"GO:0030917","count":1},{"id":"GO:0043010","count":1}]},{"hash":"955548561473783826","title":"Developmental gene regulation and chromatin remodeling","description":"The GO terms span developmental processes (atrial septum development, neural retina development, AV valve morphogenesis) alongside molecular regulatory activities (chromatin remodeling, negative regulation of transcription by RNA polymerase II, ubiquitination, cell cycle control). This suggests a cluster of proteins involved in regulating gene expression during development, rather than a single straightforward pathway. The small size and mix of functions give moderate confidence in a cohesive theme.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0003283","count":1},{"id":"GO:0043044","count":1},{"id":"GO:0043066","count":1},{"id":"GO:0000122","count":1},{"id":"GO:0003407","count":1}]},{"hash":"60128465376470908","title":"Drosophila embryonic and eye development","description":"The cluster\u2019s top GO terms cluster around embryonic development and differentiation, including germ-band extension, stem cell differentiation, and specific eye-related differentiation processes (compound eye cone cells and R7 cell development). This points to a cohesive theme of developmental programs in Drosophila, with several terms tied to embryogenesis and organ formation; a few terms appear cross-species or obsolete, but the dominant pattern supports a developmental/differentiation label.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901522","count":3},{"id":"GO:0007377","count":3},{"id":"GO:0048863","count":2},{"id":"GO:0032743","count":2},{"id":"GO:0030854","count":2}]},{"hash":"1252840262194978679","title":"Diverse Metabolic Pathways","description":"The GO terms include fatty acid beta-oxidation, phenylacetate catabolism, valine catabolism, menaquinone and phylloquinone biosynthesis, and antibiotic biosynthesis. This indicates a broad metabolism of small molecules and vitamins in bacteria rather than a single precise function, so a broad metabolic label is appropriate.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006635","count":3},{"id":"GO:0010124","count":3},{"id":"GO:0009234","count":3},{"id":"GO:0006574","count":3},{"id":"GO:0017000","count":3}]},{"hash":"349238624153121033","title":"Unknown","description":"The GO terms are highly heterogeneous, including epigenetic regulation, glucose signaling, peroxisome targeting, secretion, RNA maturation, phagolysosome assembly, GTPase regulation, and development/apoptosis. There is no clear shared function or pathway linking these proteins, so a specific, representative label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061087","count":2},{"id":"GO:0010255","count":1},{"id":"GO:0006625","count":1},{"id":"GO:0030157","count":1},{"id":"GO:0035246","count":1}]},{"hash":"1698303349631514657","title":"Ubiquitin-Dependent Protein Degradation","description":"This cluster shows a strong enrichment for ubiquitin-related processes, including ubiquitin-dependent protein catabolic process, protein polyubiquitination, and the ubiquitin-dependent ERAD pathway, indicating a core involvement in tagging and degrading proteins; additional terms related to transcription regulation and development may reflect broader regulatory roles of such proteins, but the dominant theme is ubiquitin-mediated proteolysis.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0061087","count":2},{"id":"GO:0060386","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0007275","count":2}]},{"hash":"997150961173566034","title":"RNA Processing and Turnover","description":"This cluster is dominated by GO terms related to RNA processing and RNA turnover, including tRNA processing, snoRNA processing, and RNase MRP-dependent mRNA catabolic processes, suggesting a common role in RNA maturation and degradation. Some other terms (like mitochondrial targeting and chromosome condensation) are less consistent, but the RNA-centric terms are the strongest signal.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072321","count":1},{"id":"GO:0045039","count":1},{"id":"GO:0006626","count":1},{"id":"GO:0090502","count":1},{"id":"GO:0000294","count":1}]},{"hash":"1237231609468677994","title":"Unknown","description":"The GO terms are highly heterogeneous (glucose signaling, peroxisome targeting, rRNA maturation, phagolysosome assembly, GTPase regulation, forebrain/cardiac development, ERAD, cell proliferation), with no clear shared function or pathway linking the three proteins. This suggests no single cohesive theme for the cluster.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010255","count":2},{"id":"GO:0006625","count":2},{"id":"GO:0035246","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0001845","count":2}]},{"hash":"378492892190781514","title":"Unknown","description":"The GO terms associated with this cluster are highly diverse and do not reflect a single coherent biological function or pathway (examples include ribosomal subunit export from nucleus, memory, VEGF signaling, plant ABA signaling, defense response, Schwann cell development, and general proliferation). With no clear common theme and no edges linking members, a meaningful, specific label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000056","count":2},{"id":"GO:0007614","count":1},{"id":"GO:1903078","count":1},{"id":"GO:0032516","count":1},{"id":"GO:0036324","count":1}]},{"hash":"142416832525939380","title":"Developmental Gene Regulation","description":"The terms cluster around regulation of gene expression and developmental patterning (ncRNA-mediated silencing, transcription initiation, developmental signaling, segment specification, and chromatin state), with a few outliers related to chromatin remodeling and tissue remodeling. This supports labeling the cluster as Developmental Gene Regulation. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016246","count":1},{"id":"GO:0048510","count":1},{"id":"GO:2000096","count":1},{"id":"GO:0007379","count":1},{"id":"GO:0043981","count":1}]},{"hash":"1772016069589929770","title":"Amino Acid Starvation Response and Autophagy","description":"The proteins cluster around nutrient-stress signaling and autophagy regulation: strong representation of amino acid and nitrogen starvation responses, together with positive regulation of autophagy, autophagosome assembly, and TORC1 signaling. This points to a cohesive theme of nutrient sensing triggering autophagic processes. Some associated terms like urea transport or xenobiotic response appear less central, but do not undermine the core autophagy/nutrient-stress theme.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045792","count":1},{"id":"GO:0006995","count":1},{"id":"GO:0034198","count":1},{"id":"GO:1903833","count":1},{"id":"GO:0042493","count":1}]},{"hash":"1685378188562778084","title":"Plant reproductive development and cell cycle control","description":"The GO terms foreground plant-specific reproductive development (inflorescence development, pollen maturation) alongside core cell-cycle processes (cell division, mitotic cell cycle). Additional terms touch on transcriptional regulation and ubiquitination, suggesting coordinated regulation during development. The strongest cohesive signal is plant reproductive development coupled with cell-cycle control.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":1},{"id":"GO:0010229","count":1},{"id":"GO:0061614","count":1},{"id":"GO:0070979","count":1},{"id":"GO:0010152","count":1}]},{"hash":"484916848037026576","title":"Aminoacyl-tRNA Synthetases","description":"The top GO terms point to aminoacyl-tRNA charging (glutamyl-, glutaminyl-, prolyl-tRNA synthetases) and translation, with tRNA modification also connected to this process. This pattern indicates the cluster comprises tRNA synthetases feeding into protein synthesis. The brain development term may reflect tissue-specific expression rather than a shared function.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0006425","count":2},{"id":"GO:0006424","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006400","count":2}]},{"hash":"823178383879799653","title":"Developmental angiogenesis and EMT","description":"This cluster is driven by GO terms tied to developmental processes, especially neural and mesodermal patterning (spinal cord and somite development) and vascular remodeling (sprouting angiogenesis, endothelial proliferation, EMT). A few outlier terms relate to metabolism or immune processes but do not define the main theme. Confidence: Medium","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":1},{"id":"GO:0001935","count":1},{"id":"GO:0002040","count":1},{"id":"GO:0001837","count":1},{"id":"GO:0006883","count":1}]},{"hash":"401633038024279414","title":"Hair Keratinization","description":"Top GO terms map to keratinization and hair cycle, suggesting these proteins participate in keratinized hair structures and hair follicle cycling.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":3},{"id":"GO:0042633","count":3}]},{"hash":"348258466082030699","title":"Nuclear Transport and Pore Organization","description":"The GO terms are dominated by nuclear-cytoplasmic transport activities: import into the nucleus (including NLS-bearing proteins), tRNA export, and nuclear pore organization, with related mitotic nuclear membrane dynamics and oligomerization terms. This points to a cohesive theme of nuclear transport machinery and pore-associated processes.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042306","count":1},{"id":"GO:0006409","count":1},{"id":"GO:0051290","count":1},{"id":"GO:0006607","count":1},{"id":"GO:0051260","count":1}]},{"hash":"1256363066972939391","title":"Flavin biosynthesis enzymes (Riboflavin/FAD/FMN)","description":"This cluster\u2019s top GO terms are strongly dominated by flavin biosynthesis: FAD biosynthetic process, riboflavin biosynthetic process, and FMN biosynthetic process, which together indicate a flavin metabolism role. The other terms (e.g., phosphorylation, transcription) appear incidental and do not define the core function. With only three proteins and some unrelated annotations, the label captures the main theme but carries moderate confidence.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006747","count":1},{"id":"GO:0009231","count":1},{"id":"GO:0033864","count":1},{"id":"GO:0016310","count":1},{"id":"GO:0009398","count":1}]},{"hash":"1548246153322584186","title":"Embryonic cardiovascular and vascular development","description":"This cluster centers on development of heart and blood/lymphatic vessels, with terms like endothelial and lymph vessel development, cardiac ventricle development, and mesodermal fate specification, plus related migratory and proliferation processes during embryogenesis. The label captures the dominant theme of cardiovascular and vascular tissue development across the GO terms.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051491","count":1},{"id":"GO:0060011","count":1},{"id":"GO:0001935","count":1},{"id":"GO:0014912","count":1},{"id":"GO:0048378","count":1}]},{"hash":"450421546530133103","title":"Meiosis and germline chromosome dynamics","description":"The terms point strongly to meiosis and germline development, with synaptonemal complex assembly, meiotic chromosome condensation, and regulation of the meiotic cell cycle in oocyte maturation being dominant signals. Other listed terms like cilium assembly, amyloplast organization, and vesicle-related processes may reflect broader cellular activities but do not override the meiosis-centric pattern. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060271","count":1},{"id":"GO:0006610","count":1},{"id":"GO:0010032","count":1},{"id":"GO:0007130","count":1},{"id":"GO:1903538","count":1}]},{"hash":"1366683434574251918","title":"Neural and Muscle Excitability Signaling","description":"This cluster centers on proteins involved in excitability and signaling across nervous, muscular, and cardiac tissues, highlighted by ion channel activity, membrane repolarization, and regulation of action potentials. Hormonal responses (testosterone, estradiol) and neurotransmitter handling (glutamate reuptake) fit the theme of modulating signaling in excitable cells, with CNS myelination and heart-rate regulation further reinforcing a broad neural-muscle system connectivity. Overall, the shared function appears to be modulation of membrane potential and excitability in neurons, muscles, and heart.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0033574","count":2},{"id":"GO:0071316","count":2},{"id":"GO:0051935","count":2},{"id":"GO:0090076","count":2},{"id":"GO:0086091","count":2}]},{"hash":"1047129334021928996","title":"Unknown","description":"The GO terms include responses to various stimuli (selenium, dexamethasone, herbicide, LPS, vitamin E), plus tissue development and polyamine biosynthesis. The lack of a cohesive biological process makes it hard to assign a specific label; the proteins appear to be involved in diverse stress responses and metabolic pathways rather than a single pathway.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010269","count":1},{"id":"GO:0019547","count":1},{"id":"GO:0001889","count":1},{"id":"GO:0060056","count":1},{"id":"GO:0071549","count":1}]},{"hash":"546808672365030672","title":"Unknown","description":"The terms span disparate processes across different contexts (vitamin D3 metabolism, sorbitol response, MAPK signaling, tissue development, apoptosis, plant hormone signaling, Schwann cell and heart morphogenesis, and toxic stress response), showing no coherent shared function for the cluster.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070640","count":2},{"id":"GO:0072709","count":2},{"id":"GO:0000196","count":2},{"id":"GO:0060484","count":2},{"id":"GO:0006915","count":2}]},{"hash":"322443553648782435","title":"Negative regulation of signaling pathways","description":"The top GO terms are dominated by negative regulation of signaling events (peptidyl-tyrosine phosphorylation, activin receptor, and BMP signaling) and related practices like receptor clustering and cytoskeletal regulation, with downstream links to osteoclast differentiation and blood coagulation. This points to a theme where the proteins act to dampen or modulate signaling cascades, rather than executing a single specific process. Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050732","count":1},{"id":"GO:0032926","count":1},{"id":"GO:0030514","count":1},{"id":"GO:0007596","count":1},{"id":"GO:0008584","count":1}]},{"hash":"842932968998720118","title":"Unknown","description":"The GO terms are highly heterogeneous (signaling, peroxisomal targeting, methylation, rRNA maturation, phagolysosome assembly, GTPase regulation, development, apoptosis, ERAD, proliferation) with no clear shared function or single dominant theme, and there are no edges linking the proteins, so a cohesive label cannot be inferred.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010255","count":1},{"id":"GO:0006625","count":1},{"id":"GO:0035246","count":1},{"id":"GO:0000462","count":1},{"id":"GO:0001845","count":1}]},{"hash":"506013968284256801","title":"Cytoskeletal organization and actin transport","description":"Reason: The dominant GO terms describe cytoskeletal rearrangements and trafficking processes\u2014sarcomere organization, actin filament-based transport, cell spreading linked to adhesion, and microtubule regulation\u2014pointing to a shared theme of cytoskeletal dynamics and intracellular transport. Some terms may reflect broader or noisier annotations, but the core signal is cytoskeleton-focused. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034446","count":3},{"id":"GO:0045214","count":3},{"id":"GO:1902405","count":2},{"id":"GO:0071670","count":2},{"id":"GO:0021692","count":2}]},{"hash":"361378793310854401","title":"Ubiquitin-mediated transcription and RNA splicing regulation","description":"This cluster is dominated by terms concerning ubiquitination and deubiquitination (K11- and K29-linked, and ubiquitin-dependent catabolic processes) alongside RNA processing terms (RNA splicing and regulation of alternative splicing). A secondary signal is transcriptional regulation via RNA polymerase II, supporting a theme where ubiquitin signaling modulates gene expression and RNA processing. Some terms touch on broader or unrelated processes, but the core pattern points to ubiquitin-driven control of transcription and splicing.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033132","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0003283","count":1},{"id":"GO:0043066","count":1},{"id":"GO:0000381","count":1}]},{"hash":"734424204443988253","title":"Unknown","description":"The GO terms span diverse regulatory areas (GTPase activity, retinoic acid receptor signaling, ubiquitin-related ERAD, microtubule dynamics, RIG-I signaling, and NF-kappaB transcriptional regulation), with several obsolete annotations. There is no single dominant function or pathway uniting these terms, making a coherent, specific label unreliable.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0048384","count":2},{"id":"GO:0030433","count":2},{"id":"GO:1902261","count":2},{"id":"GO:0007026","count":2}]},{"hash":"808087316872589856","title":"LPS and exopolysaccharide biosynthesis","description":"This cluster centers on biosynthesis of surface polysaccharides, including lipopolysaccharide (LPS) components (O antigen, core) and slime layer/exopolysaccharides, as well as UDP-N-acetylglucosamine\u2014the common precursor for these pathways. The terms point to building the bacterial cell envelope and extracellular polysaccharides, while a few entries (molybdenum cofactor biosynthesis, antibiotic response) are less directly related and may reflect broader metabolic or stress-related connections.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008360","count":1},{"id":"GO:0009103","count":1},{"id":"GO:1902758","count":1},{"id":"GO:0006048","count":1},{"id":"GO:0009244","count":1}]},{"hash":"1733518818334606613","title":"Tissue Morphogenesis and ECM Remodeling","description":"This cluster\u2019s top GO terms center on development and shaping of tissues (pulmonary artery, coronary artery, ciliary body, gland development) and on extracellular matrix interactions (collagen catabolic regulation, cell-matrix adhesion). A few terms about exocytosis and oxidant detoxification appear, but the dominant signal is morphogenesis coupled with ECM remodeling, suggesting a theme of tissue development and matrix dynamics.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0010710","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0010756","count":1},{"id":"GO:0048732","count":1}]},{"hash":"1075667004742160200","title":"Organellar ribosome biogenesis and RNA processing","description":"Most top terms cluster around organellar RNA processing and ribosomal large subunit assembly (mitochondrial and chloroplast), with associated RNA and protein methylation steps. This points to a shared role in ribosome maturation within mitochondria and chloroplasts, making organellar ribosome biogenesis the strongest thematic label. Other metabolism terms are present but less coherently linked to a single function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045333","count":1},{"id":"GO:0000963","count":1},{"id":"GO:1902775","count":1},{"id":"GO:1901259","count":1},{"id":"GO:0018013","count":1}]},{"hash":"816249032051638166","title":"Amino acid and phenolic compound biosynthesis","description":"These terms cluster around biosynthetic processes, with strong emphasis on amino acid production (aspartate, threonine, homoserine, lysine pathways) and also pathways for phenolic/anthocyanin compounds, plus related biosynthetic processes, suggesting a general theme of biosynthesis across these proteins.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009718","count":1},{"id":"GO:0006531","count":1},{"id":"GO:0009088","count":1},{"id":"GO:0019877","count":1},{"id":"GO:0019878","count":1}]},{"hash":"1238049366167552384","title":"Ubiquitin-regulated protein turnover","description":"Reasoning: The terms center on ubiquitin-related regulation and proteasome-dependent protein turnover (negative regulation of protein ubiquitination; regulation of proteasomal ubiquitin-dependent protein catabolic process; ufmylation). Several terms also touch on signaling pathways (NF-kappaB, estrogen receptor signaling, LPS response) that are commonly controlled by ubiquitination and proteasomal degradation, supporting a theme of post-translational modification governing cellular signaling and differentiation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":1},{"id":"GO:0060252","count":1},{"id":"GO:1990592","count":1},{"id":"GO:0001649","count":1},{"id":"GO:0032088","count":1}]},{"hash":"2133699765800354258","title":"Membrane Solute Transporters","description":"The GO terms are dominated by transmembrane transport of diverse solutes (nitrate, sugars, ions, xenobiotics), suggesting the proteins function as transporters across membranes rather than a single substrate; the cluster likely groups solute transporter activities across different substrates.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0071332","count":3},{"id":"GO:0043252","count":3},{"id":"GO:0015706","count":3}]},{"hash":"434569213163633721","title":"mRNA Splicing and Processing","description":"This cluster is dominated by GO terms related to spliceosome-mediated mRNA processing, including mRNA splicing (cis and via spliceosome), alternative splicing regulation, splice site recognition, RNA processing, mRNA export, and translation reinitiation, indicating the proteins are components of the spliceosome and broader RNA maturation machinery.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":1},{"id":"GO:0000380","count":1},{"id":"GO:0060211","count":1},{"id":"GO:0045292","count":1},{"id":"GO:0016556","count":1}]},{"hash":"1442813523279117914","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019673","count":2},{"id":"GO:0097171","count":2},{"id":"GO:0009103","count":2},{"id":"GO:0009718","count":2},{"id":"GO:0009242","count":2}]},{"hash":"1039389988318218519","title":"Stress response and ubiquitin-mediated quality control","description":"The terms point to cellular stress responses (UV-C, acidic pH, ER stress with eIF2alpha phosphorylation) and protein quality control pathways (K48-linked ubiquitination, ERAD, and SUMO modification). Together these indicate a cluster focused on maintaining protein homeostasis under stress, with links to signaling pathways like hypoxia/HIF-1alpha and androgen receptor regulation.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046621","count":1},{"id":"GO:1990451","count":1},{"id":"GO:0033235","count":1},{"id":"GO:0060765","count":1},{"id":"GO:1902073","count":1}]},{"hash":"2162073427967525192","title":"Immune and skeletal tissue development","description":"The top GO terms point to both immune functions (antigen processing and presentation via MHC class II, activation/proliferation of T cells) and skeletal/connective tissue processes (osteoblast proliferation, cartilage condensation, cell-matrix adhesion, hematopoietic stem cell homeostasis). This suggests a theme of immune-skeletal interaction or osteoimmune signaling rather than a single narrow function. Confidence is Medium.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015705","count":1},{"id":"GO:1901862","count":1},{"id":"GO:0061484","count":1},{"id":"GO:0014912","count":1},{"id":"GO:0033690","count":1}]},{"hash":"674573723593302560","title":"Innate Immune Activation and Cytokine Signaling","description":"The cluster is dominated by immune-related terms such as defense response to bacterium, neutrophil chemotaxis, and positive regulation of TNF and IL-12 production, indicating innate immune activation and inflammatory signaling. A few terms pertain to pigment cell processes (melanosome transport, melanocyte differentiation), which are less central to the cluster\u2019s core theme, but do not override the overall inflammatory/immunoregulatory pattern.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":2},{"id":"GO:0032402","count":1},{"id":"GO:0030318","count":1},{"id":"GO:0050954","count":1},{"id":"GO:2000345","count":1}]},{"hash":"1643328854879926326","title":"GPCR signaling regulation in heart and brain","description":"The cluster centers on GPCR signaling modulation: several terms indicate positive regulation of GPCR signaling, serotonin receptor signaling, and dopamine secretion, along with heart contraction and vascular smooth muscle contraction. Although there is some immune-related term (dendritic cell chemotaxis), the dominant theme is GPCR-mediated signaling contributing to cardiovascular and neural regulation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":3},{"id":"GO:0031649","count":3},{"id":"GO:2000420","count":3},{"id":"GO:0001997","count":3},{"id":"GO:0045745","count":3}]},{"hash":"1358108313579641661","title":"Unknown","description":"The terms span diverse processes (ionizing radiation response, translation, actin regulation, vesicle trafficking, meiosis, plastid organization) with no single shared function, so a cohesive label is not inferable.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071479","count":1},{"id":"GO:0006414","count":1},{"id":"GO:1990145","count":1},{"id":"GO:0032232","count":1},{"id":"GO:0006895","count":1}]},{"hash":"1744315611995287565","title":"Hair Keratinization","description":"The cluster\u2019s top GO terms are keratinization and hair cycle, both central to hair follicle biology and keratinocyte differentiation, suggesting a role in hair fiber formation or follicular cycling.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":3},{"id":"GO:0042633","count":3}]},{"hash":"2304190029077869581","title":"Neuronal synapse localization and signaling","description":"The top GO terms cluster around neural functions: protein localization to synapse, glutamate secretion, sensory perception of light, grooming behavior regulation, and cellular responses to morphine, pointing to synaptic transmission and sensory processing. Some terms refer to junctional/cytoskeletal assembly (zonula adherens, microvillus) which may reflect structural aspects of neuronal systems. Although there are no edges in this cluster, the dominant theme is neural signaling and synaptic organization.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000821","count":3},{"id":"GO:0035418","count":3},{"id":"GO:0019933","count":3},{"id":"GO:0045186","count":3},{"id":"GO:0050953","count":3}]},{"hash":"1499430539598674867","title":"Autonomic GPCR signaling and cardiovascular regulation","description":"GO terms center on GPCR signaling and its downstream effects on heart contraction, vascular smooth muscle, and neurotransmitter regulation, with additional cues from dendritic cell chemotaxis. This suggests a cluster of proteins involved in autonomic GPCR pathways that modulate cardiovascular tone and neurotransmitter release.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033861","count":3},{"id":"GO:0031649","count":3},{"id":"GO:2000420","count":3},{"id":"GO:0001997","count":3},{"id":"GO:0045745","count":3}]},{"hash":"758286110950714219","title":"Epigenetic transcription regulation and development","description":"This cluster centers on transcriptional control and epigenetic regulation, highlighted by terms for negative regulation of transcription by RNA Pol II and histone H3-K4 modifications, plus a developmental and apoptosis-related context (organ development and apoptotic signaling). While there are some unrelated terms (centrosome cycle, immune tolerance), the strongest signal is epigenetic regulation of gene expression tied to development. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002458","count":1},{"id":"GO:0034720","count":1},{"id":"GO:0000122","count":1},{"id":"GO:0080182","count":1},{"id":"GO:0007098","count":1}]},{"hash":"1628303381717887271","title":"Unknown","description":"The top terms are diverse and only single-instance: GPCR catabolic process, endosome-to-lysosome transport, positive regulation of dendritic spine morphogenesis, and phosphatidylglycerol biosynthetic process. With no shared dominant function and no edges or interactions among proteins, there is no clear unifying theme to assign a specific label.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990172","count":1},{"id":"GO:0008333","count":1},{"id":"GO:0061003","count":1},{"id":"GO:0006655","count":1}]}]