{"hash":"1094649635936733347","title":"ER protein quality control and deubiquitination","description":"The top GO terms cluster around protein deubiquitination, ERAD (ubiquitin-dependent ER-associated degradation), regulation of endopeptidase activity, and deglycosylation, indicating a module centered on ER proteostasis and ubiquitin-mediated turnover. Negative/regulatory terms further suggest tuning of ubiquitin/protease activity within this pathway, despite some obsolete annotations. Overall, the cluster appears to represent ER-associated protein quality control and ubiquitin-dependent degradation.","confidence":"High","size":13,"edges":72,"triangles":229,"max_degree":12,"top_function":null,"members":[{"accession":"XP_001363424.2","go_terms":["GO:0032024","GO:0035786","GO:0036444","GO:0051561"]},{"accession":"XP_001363867.2","go_terms":[]},{"accession":"XP_001365544.1","go_terms":["GO:0032436","GO:0070911","GO:0034126","GO:0090204","GO:0010286","GO:1901896","GO:0071276","GO:0043392","GO:0060334","GO:0051572","GO:0016925","GO:0043433","GO:0035186","GO:0086004","GO:0030578","GO:1902260","GO:0045944","GO:0045759","GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412"]},{"accession":"XP_001368264.1","go_terms":["GO:0043248","GO:0010950"]},{"accession":"XP_001373967.2","go_terms":["GO:0034389","GO:0007253","GO:0031134","GO:1904293","GO:0031468","GO:0002814","GO:2000157","GO:0030433","GO:0061060","GO:0008219","GO:1903094","GO:0045454"]},{"accession":"XP_001375313.1","go_terms":["GO:0006284","GO:0097510"]},{"accession":"XP_001376973.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_007476803.1","go_terms":["GO:0006559","GO:0033345","GO:0006517","GO:0006508"]},{"accession":"XP_007483749.1","go_terms":["GO:0000244","GO:0000266","GO:0060389","GO:0034394","GO:0030509","GO:0006511","GO:0035520","GO:0031397","GO:0035616","GO:0007179"]},{"accession":"XP_007487644.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_016277533.1","go_terms":["GO:0060340","GO:1901097","GO:0006468","GO:1901340","GO:0035458","GO:0000226","GO:0030010","GO:0001828","GO:0001827","GO:1903094","GO:1904153","GO:2000157","GO:0010994","GO:0035973","GO:1904378","GO:0030474","GO:0032815","GO:1903071","GO:0006289","GO:0034140","GO:0035523","GO:0030433","GO:0035278","GO:0035329","GO:0044313","GO:1900186","GO:0070059","GO:0016567","GO:1904021","GO:0006517","GO:0000423","GO:0033132","GO:1902236","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:1901799","GO:1902283","GO:0016579","GO:0017085","GO:0051865","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1904049","GO:0006412"]},{"accession":"XP_016278416.2","go_terms":["GO:0034389","GO:0007253","GO:0031134","GO:1904293","GO:0031468","GO:0002814","GO:2000157","GO:0030433","GO:0061060","GO:0008219","GO:1903094"]},{"accession":"XP_016279494.1","go_terms":["GO:0043248","GO:0010950"]}],"graph":[["XP_001373967.2","XP_001363424.2",0.987],["XP_001373967.2","XP_001363867.2",0.958],["XP_001373967.2","XP_001365544.1",0.878],["XP_001373967.2","XP_001368264.1",0.98],["XP_001373967.2","XP_001376973.1",0.938],["XP_001373967.2","XP_001375313.1",0.962],["XP_001373967.2","XP_007476803.1",0.932],["XP_001373967.2","XP_007483749.1",0.99],["XP_001373967.2","XP_007487644.1",0.976],["XP_001373967.2","XP_016277533.1",0.987],["XP_001373967.2","XP_016278416.2",0.868],["XP_001373967.2","XP_016279494.1",0.99],["XP_016277533.1","XP_007483749.1",0.986],["XP_016277533.1","XP_007487644.1",0.936],["XP_016277533.1","XP_016278416.2",0.87],["XP_016277533.1","XP_016279494.1",0.986],["XP_016277533.1","XP_001363424.2",0.933],["XP_016277533.1","XP_001363867.2",0.97],["XP_016277533.1","XP_001365544.1",0.93],["XP_016277533.1","XP_001368264.1",0.986],["XP_016277533.1","XP_001375313.1",0.804],["XP_016277533.1","XP_001376973.1",0.903],["XP_016277533.1","XP_007476803.1",0.944],["XP_001363424.2","XP_001376973.1",0.736],["XP_001363424.2","XP_001375313.1",0.927],["XP_001363424.2","XP_001368264.1",0.96],["XP_001363424.2","XP_001365544.1",0.726],["XP_001363424.2","XP_001363867.2",0.846],["XP_001363424.2","XP_007487644.1",0.954],["XP_001363424.2","XP_007483749.1",0.983],["XP_001363424.2","XP_007476803.1",0.972],["XP_001363424.2","XP_016278416.2",0.803],["XP_001363424.2","XP_016279494.1",0.958],["XP_016278416.2","XP_007487644.1",0.72],["XP_016278416.2","XP_001363867.2",0.852],["XP_016278416.2","XP_001375313.1",0.654],["XP_016278416.2","XP_001376973.1",0.84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