[{"hash":"1330674309894239055","title":"Neural Development and Synaptic Signaling","description":"The cluster is dominated by neural-related functions: neurotransmitter secretion, GPCR signaling, retinal ganglion cell axon guidance, and positive regulation of synapse assembly, plus terms for excitatory postsynaptic potential and development of neural structures like Schwann cells and the substantia nigra. A couple of terms about DNA replication and mitotic cell cycle seem less connected, likely noise or multi-functional proteins, but the overall theme clearly points to neuronal development and synaptic signaling.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007269","count":6},{"id":"GO:0007205","count":5},{"id":"GO:0031290","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0006260","count":4}]},{"hash":"426862409744187455","title":"Membrane repair, autophagy, and inflammatory regulation","description":"The top GO terms converge on membrane integrity maintenance (plasma membrane repair), autophagy, and suppression of inflammatory signaling (negative regulation of NLRP3 inflammasome assembly and IL-1\u03b2 production). Additional terms touch on stress-related regulation of signaling and protein turnover (PML bodies, vitamin D receptor signaling, ubiquitin-dependent catabolic processes). Taken together, these terms reflect a cohesive theme of cellular stress response that integrates membrane repair, autophagy, and modulation of innate immune responses. Confidence: Medium","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0001778","count":5},{"id":"GO:0006914","count":4},{"id":"GO:0070562","count":4},{"id":"GO:0007182","count":4},{"id":"GO:2000059","count":4}]},{"hash":"1756911397024604902","title":"Unknown","description":"The top GO terms are diverse with no single dominant function: while several terms point to neural development and signaling (axonogenesis, visual perception, excitatory postsynaptic potential), others relate to innate immunity and various developmental processes (placenta, heart development, estrogen response). This lack of a coherent shared function suggests no clear cluster theme.","confidence":"","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006349","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0007409","count":5}]},{"hash":"1805716471967521849","title":"Vertebrate Embryonic Development","description":"The top GO terms span neural crest migration, midbrain and eye development, organogenesis (pancreas, digestive tract, ureteric bud), peripheral nervous system neuron development, and primitive streak formation, all hallmark processes of vertebrate embryogenesis. A transcriptional regulatory term (negative regulation of RNA polymerase II) suggests involvement in controlling developmental gene expression. This supports labeling the cluster as related to vertebrate embryonic development and patterning.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":17},{"id":"GO:0001755","count":7},{"id":"GO:0035019","count":7},{"id":"GO:0048557","count":6},{"id":"GO:0090190","count":6}]},{"hash":"1326491756297040603","title":"Unknown","description":"The top GO terms cover metabolism (retinol and fructose biosynthesis), immune response (to lipopolysaccharide), organ/system level processes (respiratory system), neural development (lateral motor column neuron migration), and hemostasis (platelet aggregation). This broad and diverse mix lacks a single cohesive functional theme tying the proteins together, so a concise, unified label cannot be confidently assigned.","confidence":"","size":29,"edges":400,"triangles":3500,"max_degree":28,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0042572","count":14},{"id":"GO:0046370","count":14},{"id":"GO:0032496","count":10},{"id":"GO:0003016","count":10},{"id":"GO:0097477","count":10}]},{"hash":"562985380017314378","title":"RNA Splicing and mRNA Processing","description":"This cluster is dominated by GO terms tied to RNA maturation and regulation, including mRNA splicing via the spliceosome, mRNA stability and export, polyadenylation, and ncRNA-mediated gene silencing, suggesting a cohesive group of proteins involved in RNA processing and splicing regulation.","confidence":"High","size":29,"edges":161,"triangles":206,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":20},{"id":"GO:0045292","count":19},{"id":"GO:0006378","count":19},{"id":"GO:0048026","count":18},{"id":"GO:0031047","count":18}]},{"hash":"847569628602793040","title":"Rho GTPase signaling and actin cytoskeleton remodeling","description":"The cluster is enriched for terms related to Rho family GTPases and small GTPase-mediated signal transduction (regulation of Rho signaling, lamellipodium assembly, small GTPase-mediated signal transduction), which point to actin cytoskeleton remodeling and cell motility. Additional terms like acrosome reaction and sensory perception of sound reflect processes that also involve cytoskeletal changes and signaling cross-talk, while Ras/PI3K-related pathways indicate broader signal transduction networks that modulate these dynamics. Overall, the common theme is regulation of Rho-family signaling driving actin-based structural changes.","confidence":"High","size":29,"edges":7,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0007605","count":3},{"id":"GO:0007340","count":3},{"id":"GO:1902476","count":3},{"id":"GO:0043552","count":3}]},{"hash":"1627469786009159293","title":"Transcription Initiation Machinery & DNA Repair","description":"This cluster is dominated by GO terms tied to transcription initiation and promoter assembly, including RNA polymerase II preinitiation complex assembly and DNA-templated transcription initiation (Pol II and Pol III). The presence of a DNA repair term suggests some overlap or co-regulation, but the strongest signal is transcription machinery components. A few terms related to viral processes or infection structure appear as secondary signals, likely context-specific annotations or broader cellular roles, but they do not override the core transcription theme.","confidence":"High","size":29,"edges":222,"triangles":757,"max_degree":28,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0051123","count":4},{"id":"GO:0006281","count":3},{"id":"GO:0006352","count":3},{"id":"GO:0006383","count":3},{"id":"GO:0071555","count":3}]},{"hash":"49015619177280555","title":"Unknown","description":"The GO terms for this cluster cover many unrelated processes (protein assembly, glycosylation, infection structure formation, cardiac hypertrophy signaling, immune homeostasis, ER-Golgi transport, xenobiotic response, cAMP signaling, synapse organization, ureteric bud branching). There is no clear, cohesive biological function linking the proteins, suggesting the cluster lacks a single representative theme. ","confidence":"","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051262","count":4},{"id":"GO:0006486","count":3},{"id":"GO:0075015","count":3},{"id":"GO:1903244","count":3},{"id":"GO:0043029","count":3}]},{"hash":"28082040866730329","title":"Ubiquitin-Dependent Neuronal Apoptosis and Synaptic Signaling","description":"The top GO terms revolve around ubiquitin-mediated protein turnover (K48-linked deubiquitination and ubiquitin-dependent catabolic process) and apoptosis, plus neuronal functions such as axon target recognition and glutamatergic synaptic transmission, suggesting a cluster of proteins linked to ubiquitin-regulated neuronal maintenance and synaptic remodeling. Some vascular terms are present but appear less central to the core theme.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0071108","count":4},{"id":"GO:0007412","count":4},{"id":"GO:0006511","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0051968","count":4}]},{"hash":"2089720709802768802","title":"Unknown","description":"The terms cover apoptotic process, bone development, cell migration regulation, renal water transport, DNA catabolic process, cell cycle regulation, DNA demethylation, xenobiotic response, and phosphatidylinositol signaling, with no single dominant function tying the cluster together. This diversity suggests no cohesive, specific function to label the cluster beyond Unknown.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0060348","count":3},{"id":"GO:0014912","count":3},{"id":"GO:2001153","count":3},{"id":"GO:0006308","count":3}]},{"hash":"1658498222376951332","title":"Hypoxia-Responsive Kinase Signaling in Development","description":"This cluster is dominated by GO terms for kinase signaling (serine/threonine and tyrosine phosphorylation) and GTPase activity, with strong signals for cellular response to hypoxia and developmental processes (skin and multicellular organism development) as well as proliferation and mitotic cell cycle. Together these suggest a signaling module that links hypoxic stress to growth and differentiation, though one term (mRNA transport) is more general.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":13},{"id":"GO:0071456","count":12},{"id":"GO:0031954","count":12},{"id":"GO:0071902","count":12},{"id":"GO:0051028","count":12}]},{"hash":"1161519705132269863","title":"Epigenetic Chromatin Regulation","description":"This cluster is dominated by GO terms related to chromatin state and histone/DNA modifications (H3-K4 and H3-K27 methylation, DNA methylation-dependent heterochromatin), plus related regulatory processes. This points to epigenetic control of gene expression during development, with a hint toward nervous system development. Obsolete terms are present but do not override the central theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0051569","count":4},{"id":"GO:0045869","count":3},{"id":"GO:0007098","count":3},{"id":"GO:0090308","count":3}]},{"hash":"1054793395787089335","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":406,"triangles":3654,"max_degree":28,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000388","count":29},{"id":"GO:0001178","count":29},{"id":"GO:0071051","count":29},{"id":"GO:0070417","count":29},{"id":"GO:0006605","count":29}]},{"hash":"974083772836633337","title":"Notch-driven epidermal differentiation and inflammation","description":"The top terms center on Notch signaling (Notch receptor processing; Notch signaling pathway) and keratinocyte differentiation, pointing to epidermal differentiation under Notch control. Concurrent inflammatory terms (leukocyte migration, TNF response, interferon response) align with skin immune responses, supporting a theme of Notch-regulated epidermal maturation with inflammation. Some terms (liver development, manganese response) are broader or peripheral, but do not override the core Notch-epidermis theme.","confidence":"Medium","size":29,"edges":19,"triangles":13,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010042","count":7},{"id":"GO:0007220","count":7},{"id":"GO:0030216","count":7},{"id":"GO:0002523","count":7},{"id":"GO:0034612","count":7}]},{"hash":"376755230311106619","title":"Cell-cycle and RNA processing machinery","description":"The most represented GO terms cluster around cell proliferation and gene expression control: mitotic cell cycle and cell division, ribosome biogenesis, and RNA processing (splicing and guanine-N7 methylation) with supporting regulation of GTPase activity and protein autophosphorylation. Although terms like brain development and defense response appear, the dominant pattern points to coordination of cell-cycle progression with RNA processing and ribosome production, consistent with a cellular growth/gene-expression program.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0043547","count":8},{"id":"GO:0042254","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0000278","count":6},{"id":"GO:0000747","count":6}]},{"hash":"928028680097695251","title":"Photoreceptor maintenance and retinal innate immunity","description":"The top GO terms point to visual perception and photoreceptor cell maintenance, suggesting a retina/photoreceptor focus. Also present are innate immune and NF-kB\u2013related signals (I-kappaB phosphorylation, defense response to virus, innate immune response), indicating immune activity linked to these cells. Additional terms for endosome-to-Golgi trafficking, cell adhesion, Rho signaling, and oxidant detoxification fit with photoreceptor maintenance and cellular dynamics. Overall, the cluster appears to combine photoreceptor maintenance with retinal innate immune signaling.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007601","count":4},{"id":"GO:0042147","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0035023","count":3}]},{"hash":"657526705211350202","title":"Protein modification and transcription regulation","description":"The top GO terms couple protein glycosylation/proteoglycan biosynthesis with ubiquitin-related processes (deubiquitination and ubiquitin-dependent catabolic), and with transcription initiation/assembly of the RNA Pol II preinitiation complex. This points to a theme where post-translational modification interfaces with transcriptional regulation. Some terms may reflect annotation noise or cross-species differences (e.g., plant cell wall biogenesis), and the absence of edges suggests the proteins are not a tightly cohesive module, hence a broad label framing both modification and transcription control.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006486","count":6},{"id":"GO:0050650","count":5},{"id":"GO:0016579","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0051123","count":4}]},{"hash":"1807653657157212642","title":"Neural development signaling","description":"The cluster is driven by terms tying to nervous system development and neuronal survival, including nervous system development, substantia nigra development, and negative regulation of neuron apoptotic process, plus frequent involvement of MAPK and Wnt signaling (ERK/JNK cascades and canonical Wnt) and GTPase activity regulation, suggesting a cohesive theme of neural development and signaling. Some terms reference broader morphogenesis (hair follicle, lung) but the dominant signal is neural development.","confidence":"High","size":29,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031532","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0070374","count":6},{"id":"GO:0043524","count":5},{"id":"GO:0021762","count":5}]},{"hash":"267862990465558775","title":"mRNA processing and translation regulation","description":"The cluster shows strong enrichment for spliceosome-mediated mRNA processing (splicing, splice site recognition, mRNA export) and translation-related processes (translation initiation/reinitiation, translation preinitiation complex), plus mRNA stability and regulatory ncRNA\u2013mediated silencing. This suggests a cohesive role in RNA maturation and control of gene expression at the level of mRNA processing and translation.","confidence":"High","size":29,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":14},{"id":"GO:0031047","count":14},{"id":"GO:0002188","count":14},{"id":"GO:0001731","count":14},{"id":"GO:0006378","count":13}]},{"hash":"1794172655727808847","title":"Neural adhesion and synapse development","description":"The top GO terms cluster around cell\u2013cell adhesion (heterophilic and homophilic), nervous system development, and synapse assembly (including paranode axon localization), indicating roles in neural connectivity and synaptogenesis. While immune-related terms like complement activation and innate immunity are present, the dominant signal supports neural adhesion and synapse formation as the core theme.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":17},{"id":"GO:0006958","count":14},{"id":"GO:0043931","count":13},{"id":"GO:0007156","count":13},{"id":"GO:0051965","count":13}]},{"hash":"1744032938689805796","title":"DNA replication and RNA processing","description":"This cluster is driven by GO terms for DNA replication, replication initiation, and DNA repair, along with mRNA processing and spliceosome-mediated splicing, indicating a core theme around nucleic acid metabolism and expression. While there are a few outliers (e.g., B cell receptor signaling, endosome transport) that may reflect multifunctional annotations, the predominant signals point to replication and RNA processing activities.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0045022","count":2},{"id":"GO:0001833","count":2}]},{"hash":"806479869013178151","title":"Chromatin silencing and nuclear organization","description":"The top GO terms are dominated by heterochromatin formation (silent mating-type cassette, rDNA) and nucleus organization, with a strong signal for transcriptional repression (negative regulation of RNA polymerase II). This points to a cluster enriched for chromatin-state regulation and chromatin-associated processes, rather than a single specific pathway. A few terms pertain to development or immunity, but they appear less central to the cluster, likely reflecting multi-functional proteins.","confidence":"Medium","size":29,"edges":46,"triangles":27,"max_degree":10,"top_function":"programmed cell death","top_go_terms":[{"id":"GO:0030466","count":12},{"id":"GO:0000122","count":11},{"id":"GO:0035023","count":10},{"id":"GO:0051290","count":10},{"id":"GO:0007283","count":10}]},{"hash":"598583287492825690","title":"Neuronal development and MAPK signaling","description":"The cluster shows a strong tilt toward neuronal development and synaptic signaling: hippocampus development, dendrite morphogenesis, excitatory postsynaptic potential, and regulation of MAPK pathways (ERK and JNK) along with PI3K activity and cytoskeletal/focal adhesion remodeling. While a couple of terms relate to immune signaling, the dominant pattern is neuronal growth, differentiation, and synaptic signaling, supporting this label.","confidence":"High","size":29,"edges":27,"triangles":0,"max_degree":27,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043552","count":27},{"id":"GO:0060079","count":27},{"id":"GO:0050852","count":27},{"id":"GO:0070374","count":27},{"id":"GO:0031532","count":27}]},{"hash":"1410190753065579747","title":"Dopaminergic GPCR-AC\u2013cAMP Signaling and Thermogenesis","description":"The top GO terms point to activation of adenylate cyclase via GPCR signaling, including dopamine receptor\u2013mediated pathways, which strongly indicates a dopaminergic GPCR-cAMP signaling module. Thermogenesis and blood pressure terms support a link to energy expenditure downstream of this signaling. Some other terms (electron transport chain, pain perception) are broader metabolic or sensory signals, but the core theme is Dopaminergic GPCR-AC\u2013cAMP signaling governing thermogenic/energy-regulatory processes.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":20},{"id":"GO:0019233","count":20},{"id":"GO:0045777","count":20},{"id":"GO:0022900","count":20},{"id":"GO:0010579","count":20}]},{"hash":"1172364982699005757","title":"Neuronal calcium signaling and synaptic plasticity","description":"The GO terms point to neural signaling and plasticity processes: memory, long-term potentiation, substantia nigra development, and calcium release/handling by the sarcoplasmic reticulum, along with transcriptional regulation by RNA polymerase II. Together, these suggest proteins in this cluster modulate calcium-dependent signaling that drives synaptic changes and memory-associated transcription.","confidence":"High","size":29,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007613","count":5},{"id":"GO:0043388","count":5},{"id":"GO:0060316","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0045944","count":4}]},{"hash":"167405047351753399","title":"Sodium-Potassium Transport and Membrane Potential","description":"Most of the top GO terms point to transmembrane transport of sodium and potassium and to establishing or maintaining the electrochemical gradient across the plasma membrane, including sodium/export/import and regulation of membrane potential. A few terms (signal peptide processing, transcription, receptor internalization) appear peripheral or noisy, but the dominant signal is ion transport and gradient regulation, justifying this label.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006465","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0031623","count":3},{"id":"GO:1903278","count":2},{"id":"GO:0090662","count":2}]},{"hash":"1664948688226149543","title":"Innate immune signaling and tissue development","description":"This cluster mixes innate immune-related terms (response to lipopolysaccharide, dendritic cell chemotaxis, neutrophil-mediated killing of bacteria) with broad organ development processes (lung, retina, heart, endothelium). The GO terms suggest both immune signaling and developmental roles across tissues, rather than a single cohesive pathway, so the label aims to reflect this dual theme without overstating a specific function.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":25},{"id":"GO:0060427","count":25},{"id":"GO:0070963","count":25},{"id":"GO:0051482","count":25},{"id":"GO:0060041","count":25}]},{"hash":"2154927389681077735","title":"Cardiac conduction system development","description":"The proteins cluster around heart electrophysiology: AV node signaling, Purkinje-to-ventricular signaling, atrial and ventricular membrane depolarization/repolarization, and regulation of heart rate via conduction. Calcium signaling and caffeine response further support cardioelectrophysiology, making the cardiac conduction/rhythm theme the dominant connection among the GO terms, with a few broad developmental terms present as context.","confidence":"High","size":29,"edges":112,"triangles":58,"max_degree":20,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043931","count":24},{"id":"GO:0007275","count":19},{"id":"GO:0060371","count":18},{"id":"GO:0086016","count":18},{"id":"GO:0086091","count":18}]},{"hash":"849535133427846638","title":"Signaling and Trafficking Regulation","description":"The cluster\u2019s GO terms point to coordinated signaling pathways (angiogenesis, NF-kappaB, TGF-beta, TORC1) along with stress responses (hypoxia) and processes tied to cellular architecture and trafficking (tight junction assembly, COPII vesicle budding), plus general regulatory activities (protein autophosphorylation, oligomerization, cell cycle\u2013related catabolic process). This suggests proteins that jointly regulate signaling cascades and trafficking/assembly during growth, stress, or development.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045766","count":7},{"id":"GO:0051260","count":5},{"id":"GO:0070830","count":5},{"id":"GO:0043123","count":5},{"id":"GO:0071560","count":4}]},{"hash":"1481009799985581603","title":"Neural development and signaling","description":"The top GO terms cluster around brain and nervous system development, regulation of synaptic vesicle exocytosis, and key developmental signaling pathways (ROBO and SHH). While there are a few outliers involving bone, kidney, or immune signaling, the dominant theme is neural development and neuronal signaling.","confidence":"High","size":29,"edges":252,"triangles":869,"max_degree":22,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":13},{"id":"GO:2000300","count":12},{"id":"GO:0010796","count":12},{"id":"GO:0031384","count":12},{"id":"GO:0043931","count":10}]},{"hash":"272624704286693944","title":"Embryonic development and organ morphogenesis","description":"The top GO terms point to embryonic tissue development across multiple organs (eye, brain, heart, pituitary, lung) and morphogenesis, with strong signals for transcriptional regulation via RNA Polymerase II. This suggests a cluster of genes involved in developmental programs and their gene-regulatory control mechanisms.","confidence":"High","size":29,"edges":193,"triangles":306,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":13},{"id":"GO:0035284","count":12},{"id":"GO:0021986","count":12},{"id":"GO:0006366","count":12},{"id":"GO:0000122","count":12}]},{"hash":"1051562342401660929","title":"Auditory mechanosensory and skeletal development","description":"The top GO terms center on auditory/mechanosensory development (auditory receptor cell development and detection of sound) and skeletal ossification, with nervous system development supporting tissue patterning; these suggest a cluster of proteins involved in inner-ear sensory maturation and bone formation, while adhesion and immune-related terms appear less central.","confidence":"Medium","size":29,"edges":5,"triangles":2,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":17},{"id":"GO:0007399","count":14},{"id":"GO:0050910","count":14},{"id":"GO:0032516","count":14},{"id":"GO:0001501","count":14}]},{"hash":"1409095401767423805","title":"Developmental Signaling and Immune Response","description":"The top GO terms point to developmental signaling (Wnt pathway, midbrain development, multicellular growth) and extracellular matrix/remodeling (collagen catabolic process, blood coagulation), alongside immune activity (defense response to Gram-positive bacteria, response to LPS, complement activation). This suggests a cluster of proteins involved in development processes that are closely linked with immune and ECM remodeling. The transcriptional regulation term is broad and may reflect general regulatory control across these functions, but the overall theme is developmental signaling with immune/ECM aspects.","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"wound healing","top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0050830","count":7},{"id":"GO:0035264","count":7},{"id":"GO:0030901","count":7},{"id":"GO:0016055","count":7}]},{"hash":"2183263416783511647","title":"LPS-triggered inflammation and coagulation","description":"This cluster is dominated by GO terms for response to lipopolysaccharide, inflammatory and immune responses, and blood coagulation, with related vascular effects (vasoconstriction) and pain perception, suggesting a cohesive theme of innate immune activation that links inflammation with coagulation and vascular regulation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032496","count":13},{"id":"GO:0007596","count":13},{"id":"GO:0006954","count":13},{"id":"GO:0006955","count":13},{"id":"GO:0045986","count":13}]},{"hash":"1022091256666770155","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":2},{"id":"GO:0000472","count":1},{"id":"GO:0000480","count":1},{"id":"GO:0000447","count":1},{"id":"GO:0045892","count":1}]},{"hash":"1724770958756240273","title":"Embryonic development and tissue morphogenesis","description":"This cluster centers on developmental processes across multiple tissues, including placenta/trophoblast differentiation, mesoderm development, palate/roof of mouth formation, cartilage and hair follicle morphogenesis, and EMT during heart and endocardial cushion formation, plus broader endocrine system development. The shared theme is embryogenesis and organ/tissue morphogenesis rather than a single specific pathway, making a name focused on embryonic development and morphogenesis appropriate.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":12},{"id":"GO:0060536","count":11},{"id":"GO:0060972","count":11},{"id":"GO:0060806","count":11},{"id":"GO:0035270","count":11}]},{"hash":"1094899905965699344","title":"Embryonic morphogenesis and organ development","description":"Represents developmental morphogenesis and organogenesis across tissues (cartilage, palate, hair follicles, placenta, pancreas, heart). The presence of left-right patterning and various tissue-specific morphogenesis terms supports a cohesive theme of embryonic development, with a minor spliceosome term as an outlier. Overall, the cluster is best described by a developmental morphogenesis signature.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":29},{"id":"GO:0060972","count":29},{"id":"GO:0060806","count":29},{"id":"GO:0035270","count":29},{"id":"GO:0003323","count":29}]},{"hash":"1104607609955908658","title":"Multi-tissue developmental signaling","description":"The cluster\u2019s prominent GO terms center on development across multiple tissues (heart, nervous system, osteoblast fate) and associated signaling pathways (insulin receptor signaling, Rho signaling, nitric oxide response). This suggests proteins involved in broad developmental signals and cell differentiation rather than a single tissue-specific function, hence the \"multi-tissue developmental signaling\" label. Some terms like cholecystokinin response and NK cell cytotoxicity regulation may reflect broader signaling roles within a developmental context.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0043552","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0014911","count":3}]},{"hash":"696661508588776953","title":"Mitochondrial Translation and Protein Import","description":"The cluster is dominated by mitochondrial-focused processes: mitochondrial translation, positive regulation of mitochondrial translation, and protein import into the mitochondrial intermembrane space, plus ubiquinone biosynthesis. These terms collectively point to mitochondrial gene expression, assembly, and respiration, with hypoxia response as a related context. Intracellular potassium homeostasis may support mitochondrial function, reinforcing the mitochondrial theme.","confidence":"High","size":28,"edges":376,"triangles":3224,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":2},{"id":"GO:0030007","count":2},{"id":"GO:0070131","count":2},{"id":"GO:0045041","count":2},{"id":"GO:0032543","count":2}]},{"hash":"799635050041049594","title":"Mitochondrial TCA Cycle and Redox Metabolism","description":"Based on the enrichment of central metabolic terms, the cluster is dominated by the TCA cycle and related carbon metabolism (2-oxoglutarate, glyoxylate cycle) and glutathione metabolism, together with oxidative stress response terms. This points to a cohesive theme of mitochondrial energy production and redox balance, with translation and hormone response terms likely reflecting broader cellular context rather than a core motif. ","confidence":"High","size":28,"edges":280,"triangles":1678,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006099","count":12},{"id":"GO:0019878","count":9},{"id":"GO:0006412","count":6},{"id":"GO:0006749","count":6},{"id":"GO:0006103","count":6}]},{"hash":"336540487709554357","title":"Ubiquitin-dependent proteolysis and proteostasis","description":"This cluster is dominated by GO terms describing ubiquitin signaling and degradation pathways: ubiquitin-dependent ERAD, autoubiquitination, K11- and K48-linked ubiquitination, SCF- and APC/C-mediated proteolysis, and associated processes like neddylation. These point to a cohesive module of protein turnover and regulation via ubiquitin tagging and proteasome degradation, with some related processes such as peroxisomal protein import and DNA repair that can involve ubiquitination. Therefore, a label focusing on ubiquitin-mediated proteolysis best captures the cluster\u2019s function.","confidence":"High","size":28,"edges":242,"triangles":1108,"max_degree":27,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030433","count":15},{"id":"GO:0051865","count":14},{"id":"GO:0070979","count":13},{"id":"GO:0031146","count":13},{"id":"GO:0016558","count":12}]},{"hash":"986631073513117013","title":"Dopaminergic signaling and sensory processing","description":"This cluster is dominated by GO terms related to neural signaling and sensory processing: dopaminergic synaptic transmission, visual perception and learning, pain perception, cocaine response, ERK signaling, prostaglandin response, and GTPase regulation. Together they point to neural communication and behavioral/sensory pathways. An outlier term like heart development is present, but the overall pattern supports a neural-signaling/ sensory theme.","confidence":"Medium","size":28,"edges":313,"triangles":1922,"max_degree":27,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":25},{"id":"GO:0007507","count":24},{"id":"GO:0070374","count":24},{"id":"GO:0048148","count":24},{"id":"GO:0010759","count":24}]},{"hash":"374684611719114399","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0019350","count":5},{"id":"GO:1990966","count":5},{"id":"GO:0097171","count":5},{"id":"GO:0034628","count":5},{"id":"GO:0009611","count":5}]},{"hash":"1548540433540396136","title":"GTPase-regulated cell polarity and cytoskeleton remodeling","description":"This cluster centers on small GTPase\u2013driven signaling that controls cell polarity and actin cytoskeleton dynamics, supported by terms for epithelial polarity establishment, cell-shape regulation, and dendrite morphogenesis, along with endocytosis and cell spreading. The presence of T cell receptor signaling and PI3K-related activity suggests integration of signaling with cytoskeletal remodeling and polarity maintenance. Overall, proteins here likely coordinate polarity cues with cytoskeletal dynamics and membrane trafficking.","confidence":"High","size":28,"edges":57,"triangles":29,"max_degree":23,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031532","count":7},{"id":"GO:0043552","count":6},{"id":"GO:0090162","count":6},{"id":"GO:0071963","count":6},{"id":"GO:0050852","count":6}]},{"hash":"1127042224748748711","title":"Morphogenesis and protein processing","description":"This cluster combines terms for cell and dendritic spine morphogenesis and ephrin signaling with strong signals for protein folding/ER targeting and unfolded protein response, suggesting a theme of developmental remodeling supported by protein synthesis and trafficking. Nuclear processes like DNA replication and transcription regulation appear as well, but the more cohesive pattern centers on morphogenesis alongside protein processing and secretion pathways.","confidence":"Medium","size":28,"edges":80,"triangles":36,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000902","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0060997","count":6},{"id":"GO:0006355","count":6},{"id":"GO:0048013","count":6}]},{"hash":"1267855613942925889","title":"mRNA splicing and translation initiation","description":"This cluster is enriched for spliceosome-related mRNA processing terms (splicing, splice site recognition, export, stability, and regulation) and also for translation initiation-related terms (preinitiation complex formation and translation reinitiation), suggesting a coordinated group of proteins involved in mRNA maturation and the initiation of translation. Confidence: High","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":13},{"id":"GO:0045292","count":12},{"id":"GO:0002188","count":12},{"id":"GO:0001731","count":12},{"id":"GO:0048026","count":11}]},{"hash":"2188140581464976747","title":"Vascular signaling and remodeling","description":"This cluster shows several GO terms centered on vascular function and tissue remodeling: GPCR signaling related to vascular tone, positive regulation of vasoconstriction, negative regulation of angiogenesis, collagen fibril organization, and cell migration. Together these imply roles in vascular signaling and extracellular matrix\u2013driven remodeling. The other terms (ubiquitination, ripoptosome assembly, telomere maintenance) may reflect broader regulatory processes but are less tied to the main vascular theme.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0045907","count":4},{"id":"GO:0030199","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0016525","count":3}]},{"hash":"697080082842297881","title":"Endothelial Activation and Angiogenic Signaling","description":"The top GO terms converge on endothelial biology and vascular dynamics: regulation of VEGF signaling and endothelial tube morphogenesis point to angiogenesis; Notch receptor processing and TNF response relate to inflammatory signaling and vascular development; leukocyte migration and integrin-mediated adhesion reflect endothelial-immune interactions. While a couple terms (keratinocyte differentiation, chondrocyte differentiation) are broader developmental signals, the dominant themes are endothelial activation, angiogenesis, and inflammation, supporting this label. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":12},{"id":"GO:0007220","count":10},{"id":"GO:0010042","count":10},{"id":"GO:0030216","count":10},{"id":"GO:0034612","count":10}]},{"hash":"970946776950624828","title":"Glycan biosynthesis and zona pellucida interactions","description":"The proteins are enriched for glycosylation and glycan biosynthetic processes (protein glycosylation, glycosphingolipid biosynthesis, keratan sulfate proteoglycan biosynthesis) and include functions linked to zona pellucida binding and penetration, plus mammary gland development and wound healing. This points to a theme of extracellular matrix and glycan modification with reproductive relevance, particularly sperm\u2013zona pellucida interactions and related epithelial remodeling. Therefore, the cluster likely reflects glycan-related processes central to fertilization and tissue development.","confidence":"Medium","size":28,"edges":51,"triangles":17,"max_degree":23,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075015","count":8},{"id":"GO:0006486","count":6},{"id":"GO:0060055","count":5},{"id":"GO:0060058","count":5},{"id":"GO:0030879","count":5}]},{"hash":"841627720198481979","title":"Developmental growth signaling and cell proliferation","description":"This cluster centers on development across multiple tissues (spinal cord, skin, retina) and essential cell division/proliferation processes, plus growth signaling (TGF-beta, TORC1) and cytoskeletal regulation (Arp2/3). The combination suggests a module coordinating developmental growth, tissue morphogenesis, and cell cycle control.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000920","count":25},{"id":"GO:0051301","count":25},{"id":"GO:0008283","count":24},{"id":"GO:0021510","count":23},{"id":"GO:0071560","count":23}]},{"hash":"1894677989044069799","title":"Neurodevelopment and Synaptogenesis","description":"This cluster shows strong enrichment for neural development-related terms: synapse assembly and organization, interneuron migration, myelination, and cell adhesion, pointing to processes governing neuronal development and synaptic formation. Innate immune response appears but is less defining than the neural-development signals, suggesting these proteins mainly participate in neurodevelopmental/synaptic functions rather than immunity per se.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045087","count":17},{"id":"GO:0042552","count":17},{"id":"GO:0051965","count":17},{"id":"GO:0021836","count":16},{"id":"GO:0014068","count":16}]},{"hash":"1920336941964131164","title":"Retina Phototransduction and GPCR Signaling","description":"The top GO terms are clustered around visual processes and opsin-mediated GPCR signaling (visual perception, regulation of opsin signaling, adenylate cyclase-activating GPCR signaling) and retinal development, with downstream ERK signaling and Rho/GTPase regulation linking to signaling cascades in retinal cells. While a few terms like heart development and blood coagulation appear, they are less representative of the core retina/GPCR signaling theme.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022400","count":6},{"id":"GO:0007601","count":6},{"id":"GO:0010579","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0035025","count":6}]},{"hash":"1654003341894302206","title":"mRNA Splicing, Export, and Stability","description":"The top GO terms cluster around spliceosome-mediated splicing, mRNA export from the nucleus, poly(A) tail regulation, and mRNA stability under stress. This suggests the proteins are involved in nuclear mRNA maturation and turnover, covering splicing, export, and regulatory processing.","confidence":"High","size":28,"edges":377,"triangles":3250,"max_degree":27,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":16},{"id":"GO:0048026","count":16},{"id":"GO:0031047","count":16},{"id":"GO:0045292","count":15},{"id":"GO:0006378","count":15}]},{"hash":"1772653696780024035","title":"Innate Antiviral Defense Proteins","description":"The cluster shows several GO terms tied to antiviral and innate immune responses (defense response to virus, innate immune response), suggesting these proteins collectively function in antiviral defense. Other terms present (peptidyl-tyrosine sulfation, protein heterooligomerization, plant hormone signaling, cadmium response) appear ancillary or due to annotation noise, and do not define the core theme. Thus, a label centered on antiviral innate immunity best represents the group, with some uncertainty due to noise terms. ","confidence":"Medium","size":28,"edges":7,"triangles":2,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051607","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0006478","count":6},{"id":"GO:0021756","count":5},{"id":"GO:0070389","count":5}]},{"hash":"167525990385864598","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006890","count":8},{"id":"GO:0006888","count":8},{"id":"GO:0006351","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0000462","count":6}]},{"hash":"939258132586675019","title":"mRNA Splicing and Stability Regulation","description":"These proteins cluster around mRNA processing: spliceosome-mediated splicing, mRNA export, and stabilization, with links to stress-responsive regulation and ncRNA-mediated silencing.","confidence":"High","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":23},{"id":"GO:0048026","count":14},{"id":"GO:0031047","count":14},{"id":"GO:0045292","count":13},{"id":"GO:1901407","count":13}]},{"hash":"390026142182864117","title":"Embryonic organogenesis","description":"The top GO terms cluster around core developmental processes\u2014heart, placenta, and face development, along with growth plate cartilage formation and retinoic acid signaling, and p38 MAPK cascade\u2014indicating a theme of embryonic organ formation and tissue patterning. A few terms about secretion regulation and transcription factor activity appear ancillary. Confidence: High","confidence":"","size":28,"edges":27,"triangles":9,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":19},{"id":"GO:0001890","count":19},{"id":"GO:0003430","count":18},{"id":"GO:0090188","count":18},{"id":"GO:0001893","count":18}]},{"hash":"1390179003529990814","title":"Vascular GPCR\u2013Rho signaling and inflammation","description":"The top GO terms cluster around blood pressure regulation (GO:0045777), GPCR signaling with adenylyl cyclase activation (GO:0010579), and positive Rho signaling (GO:0035025), pointing to signaling pathways that control vascular tone. Additional terms reflect inflammatory/immune responses (GO:0006954, GO:0032496) and coagulation, with pain and appetite signals suggesting broader systemic regulation. The presence of an electron transport chain term is less specific but common to many proteins, leaving vascular signaling and inflammation as the core theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":21},{"id":"GO:0022900","count":21},{"id":"GO:0010579","count":21},{"id":"GO:0035025","count":21},{"id":"GO:0019233","count":20}]},{"hash":"1986878371636475333","title":"Cardiac calcium handling and SR calcium release regulation","description":"Top GO terms indicate focused involvement in calcium signaling related to ryanodine receptor regulation and sarcoplasmic reticulum calcium release, with support from cardiac tissue morphogenesis. While some terms reflect general cellular processes (nuclear import, mRNA transport), the recurrent calcium/SR-related functions strongly define the cluster as related to cardiac calcium handling and excitation-contraction coupling.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060315","count":6},{"id":"GO:0055010","count":6},{"id":"GO:0051301","count":5},{"id":"GO:0032515","count":5},{"id":"GO:0042542","count":5}]},{"hash":"1669310594574191396","title":"Mitotic cell cycle control in epithelial proliferation","description":"This cluster is dominated by cell-cycle\u2013related terms (G1/S transition, regulation of cell cycle, CDK activity, spindle pole separation) along with epithelial proliferation/differentiation terms, suggesting a cohesive theme of mitotic progression and transcriptional regulation during epithelial cell growth. Some outliers exist (general transcription and viral transcription) but do not override the main signal.","confidence":"High","size":28,"edges":12,"triangles":2,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000082","count":17},{"id":"GO:0071157","count":16},{"id":"GO:0045737","count":16},{"id":"GO:0006351","count":15},{"id":"GO:0033598","count":14}]},{"hash":"1225869455354373708","title":"Neural development and secretory trafficking","description":"The cluster is enriched for nervous system and brain development terms (and kidney development), along with vesicle trafficking processes such as ER-to-Golgi transport and COPII-coated vesicle budding, plus phospholipid homeostasis. This suggests a link between neural developmental programs and the secretory pathway, indicating proteins may coordinate growth and maturation of neural tissues via vesicle transport and membrane lipid regulation.","confidence":"Medium","size":28,"edges":93,"triangles":62,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010628","count":6},{"id":"GO:0055091","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0006888","count":6}]},{"hash":"1251418062172691524","title":"Developmental Regulation and Gene Expression","description":"The top GO terms indicate broad developmental roles (neuron projection development, skin development, single fertilization) combined with regulatory activities (DNA-templated transcription, histone H3-K9 methylation, ubiquitination, GTPase regulation, autophosphorylation control, and cell division), suggesting a cluster of proteins involved in development linked to transcriptional and signaling regulation rather than a single pathway.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031175","count":5},{"id":"GO:0043588","count":4},{"id":"GO:0007338","count":4},{"id":"GO:0071276","count":4},{"id":"GO:0031954","count":4}]},{"hash":"1461953250731727840","title":"Cardiac Electrophysiology and Mechanotransduction","description":"This cluster is highlighted by GO terms related to heart electrical activity, including regulation of SA node cell action potential and positive regulation of membrane depolarization during cardiac muscle cell action potential, as well as a broad signal for mechanosensation (cellular response to mechanical stimulus, detection of mechanical stimulus involved in pain). These points suggest a core theme around cardiac electrophysiology and mechanotransduction, with some terms (e.g., NOD2 signaling, fat cell differentiation, prostate development) likely representing background or off-target annotations. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":6},{"id":"GO:0098907","count":6},{"id":"GO:0045444","count":6},{"id":"GO:0070431","count":5},{"id":"GO:0060843","count":5}]},{"hash":"742638076934984984","title":"Secondary Metabolite Biosynthesis and Defense","description":"The top GO terms indicate biosynthesis of small molecule metabolites (biotin, antibiotics, strigolactone, alkaloids) and related defense/detox responses (response to toxic substance, defense against Gram-positive bacteria, xenobiotic stimulus), with a few outliers like axonogenesis and triglyceride catabolic process. This suggests the cluster centers on metabolite production with detoxification/defense roles, hence the chosen label.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009102","count":6},{"id":"GO:0009636","count":6},{"id":"GO:0017000","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0035562","count":5}]},{"hash":"778590679831802156","title":"Calcium-dependent immune signaling","description":"The top GO terms point to immune activation (IL-6/IL-10 production, B cell proliferation) combined with calcium signaling (calcium import, store-operated calcium entry) and endosomal lumen acidification, suggesting a core theme of calcium-regulated immune responses. Some terms on mammary gland development and ovulation hint at broader hormonal contexts but are less central.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032755","count":4},{"id":"GO:0048388","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0061180","count":3},{"id":"GO:0070509","count":3}]},{"hash":"2041958860314313246","title":"Ubiquitin-mediated protein turnover and antiviral immunity","description":"The top GO terms point strongly to ubiquitin-dependent protein catabolic processes and specific ubiquitin linkages (K63, K6) including autoubiquitination, indicating a cluster rich in ubiquitin-regulated protein turnover. Coupled with innate immune and defense responses to virus, this suggests the proteins participate in antiviral defense mechanisms controlled by ubiquitination and possibly chromatin dynamics (histone catabolic process). Vitamin D response and circadian rhythm terms may be secondary associations. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:0070534","count":9},{"id":"GO:0033280","count":9},{"id":"GO:0051607","count":9},{"id":"GO:0045087","count":9}]},{"hash":"1887336922623992971","title":"Organ Development and Immune Response","description":"The proteins in this cluster are annotated with a mix of organ development terms (heart, retina, lung connective tissue, retina development, endothelial barrier regulation) and immune-related terms (eosinophil degranulation regulation, neutrophil killing of Gram-negative bacteria, response to LPS, dendritic cell chemotaxis). With no observed network edges, the cluster seems to group genes involved in diverse developmental and immune processes rather than a single coherent pathway, so this combined label best captures the shared functional themes.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":28},{"id":"GO:0060427","count":28},{"id":"GO:0070963","count":28},{"id":"GO:0051482","count":28},{"id":"GO:0060041","count":28}]},{"hash":"1406664245541159896","title":"Immune and inflammatory signaling cluster","description":"This cluster is dominated by GO terms for immune response, inflammatory response, and response to lipopolysaccharide, with related signaling activities (neuropeptide signaling, calcium release). While a few terms (phototransduction, bone remodeling, diet-induced thermogenesis, temperature response) are more peripheral, the strongest and most frequent functions point to immune/inflammatory signaling.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006955","count":11},{"id":"GO:0019233","count":11},{"id":"GO:0046849","count":11},{"id":"GO:0032496","count":10},{"id":"GO:0006954","count":10}]},{"hash":"983441965320719995","title":"Immune signaling and tissue development","description":"Based on the top GO terms, the cluster is enriched for immune activation signals (eosinophil degranulation, neutrophil killing, LPS response, dendritic cell chemotaxis) together with several organ development and tissue-context terms (lung connective tissue development, retina/heart development, endothelial barrier regulation). This combination suggests a set of genes involved in immune signaling expressed in developing or barrier tissues, giving a coherent but broad theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":28},{"id":"GO:0060427","count":28},{"id":"GO:0070963","count":28},{"id":"GO:0051482","count":28},{"id":"GO:0060041","count":28}]},{"hash":"575143426850124690","title":"Immune Activation and Organ Development","description":"The cluster's top GO terms are dominated by immune-related processes (eosinophil degranulation, neutrophil-mediated killing of bacteria, dendritic cell chemotaxis, response to LPS), indicating a strong immune function. It also includes development terms for heart, retina, and lung connective tissue, suggesting some members are involved in developmental pathways as well. Overall, the proteins appear linked to immune signaling intertwined with organogenesis.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":28},{"id":"GO:0060427","count":28},{"id":"GO:0070963","count":28},{"id":"GO:0051482","count":28},{"id":"GO:0060041","count":28}]},{"hash":"1720967730935741204","title":"Prostaglandin-driven inflammatory response and GPCR signaling","description":"This cluster is dominated by GO terms tied to prostaglandin E stimulus, inflammatory and xenobiotic responses, LPS response, blood coagulation, GPCR signaling, and calcium release, all indicative of an inflammatory, prostaglandin-mediated program with GPCR involvement. A minor signal related to electron transport may reflect metabolic changes in activated cells, but the overarching theme is inflammation and GPCR-driven signaling. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":15},{"id":"GO:0042493","count":14},{"id":"GO:0019233","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0032496","count":13}]},{"hash":"390883911640759094","title":"RNA silencing and translation control","description":"This cluster is enriched for RNA-centric processes: translation (GO:0006412) predominates (16), along with RNA silencing pathways (global gene silencing by mRNA cleavage) and miRNA biogenesis (pre-miRNA processing). Additional terms reflect regulation of translation initiation via eIF2 alpha phosphorylation, and broader regulation of signaling and antiviral responses. A few outliers suggest developmental and dosage regulatory roles, but the dominant theme links RNA metabolism to translational control and innate defense.","confidence":"High","size":27,"edges":328,"triangles":2603,"max_degree":26,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":16},{"id":"GO:0046677","count":6},{"id":"GO:0010998","count":6},{"id":"GO:0044387","count":6},{"id":"GO:0030423","count":6}]},{"hash":"1325684940748098094","title":"Broad developmental morphogenesis","description":"The top GO terms span diverse developmental processes (gonad development, forebrain regionalization, haltere morphogenesis, paramesonephric duct development) and cytoskeletal remodeling (actin filament bundle assembly), suggesting a common theme of tissue patterning and morphogenesis across organs rather than a single pathway. ","confidence":"Medium","size":27,"edges":24,"triangles":9,"max_degree":6,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0008585","count":12},{"id":"GO:0030579","count":10},{"id":"GO:0021937","count":9},{"id":"GO:0050859","count":9},{"id":"GO:0071657","count":9}]},{"hash":"732102636504551169","title":"Neural development and behavior","description":"This cluster is driven by nervous-system\u2013related functions: brain development, memory, and adult locomotory behavior are prominently represented, with supportive signals for circadian rhythm and corticosterone response. Although there are general cellular terms (apoptotic process, translation, xenobiotic response), the strongest theme points to neural development and behavioral roles, justifying a neural development/behavior label. ","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:0042493","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0008284","count":4},{"id":"GO:0051412","count":4}]},{"hash":"2233345274537850811","title":"Mitochondrial Assembly and Steroid Biosynthesis","description":"The top GO terms cluster around mitochondrial structure and function, including complex IV assembly and respirasome assembly, plus regulation of cytochrome c release, suggesting strong mitochondrial involvement. Additional terms point to lipid and steroid metabolism (sphingolipid, retinol, tetrahydrobiopterin, glucocorticoid, and testosterone biosynthesis), implying a link between mitochondrial processes and lipid/steroid biosynthesis pathways. Overall, the proteins appear connected through mitochondrial assembly/function with a downstream theme of lipid and steroid metabolism.","confidence":"Medium","size":27,"edges":12,"triangles":5,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0033617","count":4},{"id":"GO:0090201","count":4},{"id":"GO:0097250","count":4},{"id":"GO:0042572","count":4},{"id":"GO:0048823","count":4}]},{"hash":"877893828983518522","title":"Spliceosome-Driven mRNA Processing and Regulation","description":"The top GO terms cluster around mRNA splicing via the spliceosome, splice site recognition, polyadenylation regulation, mRNA export, and mRNA stability, as well as regulatory ncRNA-mediated gene silencing. This points to a cohesive group of proteins involved in mRNA maturation and post-transcriptional control, especially splicing and RNA stability/export mechanisms.","confidence":"High","size":27,"edges":127,"triangles":303,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":9},{"id":"GO:0006378","count":9},{"id":"GO:0048026","count":8},{"id":"GO:0031047","count":8},{"id":"GO:0010610","count":8}]},{"hash":"621363056801266205","title":"Regulated kinase and GTPase signaling","description":"Top GO terms converge on signaling enzyme regulation, including positive/negative regulation of GTPase activity and protein kinase activity (autophosphorylation and serine/threonine kinase activity), with associated development and stress-response processes (skeletal muscle fiber development, substantia nigra development, and cellular response to hypoxia). The presence of mRNA transport and mitotic cell cycle suggests broader cellular regulation, but the core motif appears to be controlled phosphorylation and signaling that influence development and stress responses. Confidence: Medium","confidence":"","size":27,"edges":168,"triangles":542,"max_degree":26,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":10},{"id":"GO:0006469","count":8},{"id":"GO:0048741","count":8},{"id":"GO:0021762","count":8},{"id":"GO:0071456","count":8}]},{"hash":"2227144654762672750","title":"Neural and craniofacial development with cytoskeletal remodeling","description":"These proteins seem tied to development in neural and craniofacial tissues (neuron development; cranial skeletal system development) and to signaling pathways (insulin receptor signaling; TGF-beta response) that guide cell behavior. The prominence of actin-related processes (lamellipodium assembly, ruffle assembly, actin cortical patch assembly) indicates coordinated cytoskeletal remodeling during morphogenesis, while chromatin remodeling and transcriptional regulation hint at broader gene expression control during differentiation. Overall, the cluster reflects a developmental program with an emphasis on signaling-driven cytoskeletal dynamics in neural/craniofacial contexts.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0008286","count":4},{"id":"GO:1904888","count":4},{"id":"GO:0071560","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0000147","count":4}]},{"hash":"1579573154138445257","title":"TLR4 Signaling and Leukocyte Adhesion and Migration","description":"This cluster is dominated by GO terms for TLR4 signaling, integrin-mediated signaling, and various adhesion and migration processes (cell-matrix adhesion, heterotypic cell-cell adhesion, extravasation, and T cell migration), pointing to innate immune activation and leukocyte trafficking. While most terms align with immune cell activation and movement, a couple (endodermal differentiation, mitotic spindle assembly) are less consistent and may reflect less-specific or broader roles in some proteins. ","confidence":"High","size":27,"edges":2,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0034142","count":11},{"id":"GO:0007161","count":10},{"id":"GO:0034113","count":10},{"id":"GO:0035987","count":10},{"id":"GO:0045123","count":10}]},{"hash":"1188590319408607189","title":"Innate Immune Signaling and Cytoskeletal Dynamics","description":"The top GO terms point to innate immune signaling pathways (type I interferon signaling, NK cell cytotoxicity) along with signaling cascades (ERK, Rho, PI3K) and processes related to cell adhesion and spreading. This combination suggests a cluster centered on immune activation that is tightly linked to cytoskeletal remodeling and adhesion, including responses to fungal-derived stimuli. ","confidence":"High","size":27,"edges":10,"triangles":0,"max_degree":3,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0071226","count":14},{"id":"GO:0060337","count":14},{"id":"GO:0070374","count":14},{"id":"GO:0043552","count":14},{"id":"GO:0071300","count":14}]},{"hash":"424908828040942677","title":"Proteostasis and Mitosis","description":"The cluster combines ubiquitin-dependent ERAD and protein polyubiquitination with microtubule dynamics, centromere/chromosome assembly, and ER-Golgi transport components, suggesting a cohesive role in protein turnover and chromosome segregation during cell division, with some links to neural development contexts.","confidence":"Medium","size":27,"edges":17,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030433","count":7},{"id":"GO:0000209","count":7},{"id":"GO:0007420","count":7},{"id":"GO:0051301","count":6},{"id":"GO:0051260","count":6}]},{"hash":"1264996973967379047","title":"Inflammatory Cytokine Signaling and Necroptosis","description":"Based on the top GO terms, the proteins cluster around cytokine production and inflammatory signaling (IL-6, IL-8, TNF, IL-10), defense against Gram-positive bacteria, and necroptotic signaling. This suggests a module coordinating cytokine-mediated immune responses and inflammatory cell death, rather than a metabolic or structural function, hence a label centered on inflammation and necroptosis.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051092","count":8},{"id":"GO:0071260","count":7},{"id":"GO:0050830","count":7},{"id":"GO:0032733","count":6},{"id":"GO:0002374","count":6}]},{"hash":"1878177229635998334","title":"ECM remodeling and coagulation","description":"The GO terms point to extracellular matrix (ECM) dynamics (metallopeptidase activity, ECM assembly regulation, cell-matrix adhesion, hyaluronan metabolism) together with blood coagulation and complement activation, suggesting a functional cluster focused on ECM remodeling and clotting/immune interfaces. Some terms like stamen formation or dendrite regeneration are less directly related, but the dominant signal reflects ECM-associated processing and coagulation pathways.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0007596","count":12},{"id":"GO:0070208","count":11},{"id":"GO:0007161","count":11},{"id":"GO:0035987","count":11},{"id":"GO:1905050","count":10}]},{"hash":"2035939920034084101","title":"Microtubule Dynamics and Mitosis","description":"These proteins cluster around microtubule-based processes: plus-end-directed vesicle transport, microtubule polarity, mitotic chromosome alignment, and microtubule depolymerization, indicating a focus on cytoskeleton dynamics and cell division; while other terms (NMD, integrin/Rap signaling, and root development) may reflect broader roles or cross-talk, the dominant pattern centers on microtubule organization and mitosis.","confidence":"High","size":27,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000184","count":8},{"id":"GO:0033624","count":8},{"id":"GO:0032487","count":8},{"id":"GO:0072383","count":8},{"id":"GO:0030951","count":8}]},{"hash":"1400017385840341926","title":"Transmembrane nutrient transport and endocytosis","description":"The cluster is enriched for various transmembrane transport terms (glucose, pantothenate, biotin, myo-inositol, sodium export), suggesting membrane transport roles. The presence of pinocytosis, microspike assembly, and Rho signaling regulation terms indicates actin-driven endocytic remodeling linked to transport; a single defense term appears incidental. Overall, the functions point to membrane transport coupled with endocytic processes.","confidence":"Medium","size":27,"edges":34,"triangles":0,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":6},{"id":"GO:0015887","count":5},{"id":"GO:0015878","count":5},{"id":"GO:0015798","count":5},{"id":"GO:0071436","count":5}]},{"hash":"1096861083782881598","title":"Neuroimmune Developmental Signaling","description":"The cluster combines strong immune-related terms (defense against Gram-positive bacteria, TH1-type response, LPS response, IFN-beta production) with neural development terms (myelination, synapse assembly), suggesting enrichment for cross-talk between immune signaling and neural development pathways; other terms like kidney development and angiogenesis likely reflect broader developmental roles or pleiotropy.","confidence":"Medium","size":27,"edges":8,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050830","count":9},{"id":"GO:0042088","count":8},{"id":"GO:0071260","count":8},{"id":"GO:0001822","count":8},{"id":"GO:0014068","count":8}]},{"hash":"47451273273846252","title":"Small-molecule biosynthesis and redox detoxification","description":"The terms cluster around biosynthesis of diverse small molecules (antibiotics, biotin, menaquinone, alkaloids, strigolactones) and processes involved in detoxifying reactive oxidants, suggesting a functionally cohesive group focused on metabolite production and redox management. A few entries like triglyceride catabolism and C-terminal demethylation are broader metabolic activities but can be seen as related to overall metabolic processing. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0055114","count":12},{"id":"GO:0098869","count":9},{"id":"GO:0017000","count":9},{"id":"GO:0009234","count":8},{"id":"GO:0009102","count":8}]},{"hash":"1481655906420664437","title":"Unknown","description":"The terms show a mix of immune/stress responses (innate immune response, defense response to virus, cellular response to cadmium ion) alongside unrelated plant signaling and neural development terms, offering no cohesive functional theme for the cluster. Therefore a safe Unknown label.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021756","count":10},{"id":"GO:0051301","count":9},{"id":"GO:2000531","count":8},{"id":"GO:0071276","count":8},{"id":"GO:0009938","count":8}]},{"hash":"2067209762866517301","title":"Wnt and Hippo signaling in development","description":"This cluster is driven by terms central to developmental signaling and growth control, especially positive regulation of canonical Wnt signaling and hippo signaling, which coordinate proliferation, differentiation, and organogenesis. Supporting terms involve differentiation of various tissues (keratinocytes, placental/vascular development) and growth-related processes (negative regulation of cardiac muscle proliferation, apoptosis), suggesting a cohesive theme of developmentally regulated growth and cell fate decisions mediated by Wnt/Hippo pathways.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060044","count":20},{"id":"GO:0030216","count":20},{"id":"GO:0090263","count":20},{"id":"GO:0006915","count":20},{"id":"GO:0035329","count":20}]},{"hash":"2207387772021169003","title":"Ribosome biogenesis and translation initiation","description":"The top GO terms are dominated by translation-related processes (translation reinitiation, formation of translation preinitiation complex) and ribosome biogenesis, indicating these proteins are enriched for components of protein synthesis and RNA processing. Additional terms (mRNA splicing, microtubule severing, chromatid cohesion, vesicle transport) suggest broader cellular roles, but the strongest signal centers on the translation machinery and ribosome assembly.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0002188","count":12},{"id":"GO:0001731","count":12},{"id":"GO:0007420","count":10},{"id":"GO:0042254","count":10},{"id":"GO:0051013","count":9}]},{"hash":"1230934289100628463","title":"Organ Development and Signaling","description":"These proteins cluster around developmental processes across several organs (multicellular organism development, kidney and heart development, nervous system development, bone ossification) and include components of heterophilic cell\u2013cell adhesion, along with signaling pathways such as ERK/MAPK and NF-kappaB. The dominant theme is organogenesis and tissue morphogenesis coupled with signaling and cell adhesion, with a possible outlier term related to host cell entry reflecting shared endocytic/adhesion machinery. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007275","count":13},{"id":"GO:0001822","count":12},{"id":"GO:0043931","count":11},{"id":"GO:0007157","count":10},{"id":"GO:0046718","count":10}]},{"hash":"1332224906665391099","title":"Embryonic Development and Differentiation","description":"The terms point to embryonic development and lineage specification (mast cell differentiation, skeletal system development, embryonic hematopoiesis, olfactory nerve formation, placode morphogenesis) with accompanying transcriptional regulation, indicating a cohesive theme of developmental differentiation and tissue morphogenesis rather than a single metabolic pathway.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060374","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0000122","count":3}]},{"hash":"925778026426448820","title":"Embryonic development and organ morphogenesis","description":"Most high-frequency GO terms relate to embryonic development, tissue differentiation, and morphogenesis across diverse organs (placenta, heart/EMT, cartilage, endocrine systems, pancreas, skeletal muscle, etc.). The common theme is developmental differentiation programs guiding tissue formation rather than a single precise function, so this label captures the cluster's broad developmental nature.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":7},{"id":"GO:0003198","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0060972","count":6}]},{"hash":"1474206393112555229","title":"Embryonic Morphogenesis and Patterning","description":"The top GO terms show multiple processes tied to tissue and organ formation during development (cartilage, hair follicles, mouth roof, mesoderm, placenta, pancreas). The shared theme is embryonic morphogenesis and pattern formation rather than a single tissue-specific function, so this label captures the cluster's essence.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":18},{"id":"GO:0060972","count":18},{"id":"GO:0060806","count":18},{"id":"GO:0031069","count":18},{"id":"GO:0060021","count":18}]},{"hash":"1368645691188670790","title":"Actin cytoskeleton regulation and cell polarity","description":"This cluster is dominated by GO terms tied to actin cytoskeleton dynamics and organization (actin cortex localization, mitotic actomyosin ring assembly, cytoskeleton reorganization) and upstream regulators like Rho signaling, along with processes like endocytosis and intracellular transport. The convergence on cytoskeletal remodeling, cell shape, and polarity suggests a cohesive theme of actin-driven regulation of cell polarity and trafficking, even with some lineage-specific terms (heart development, locomotion). ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0030100","count":3},{"id":"GO:0007507","count":3},{"id":"GO:1903475","count":3}]},{"hash":"831087313572790814","title":"Embryonic morphogenesis and tissue development","description":"The GO terms are dominated by broad embryonic development and tissue morphogenesis across multiple lineages (cartilage morphogenesis, mesoderm development, left/right patterning, placenta and pancreatic cell development, hair follicle morphogenesis, roof of the mouth, EMT in heart formation, etc.), suggesting proteins involved in embryogenesis and organogenesis rather than a single tissue-specific function.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":23},{"id":"GO:0060972","count":23},{"id":"GO:0060806","count":23},{"id":"GO:0035270","count":23},{"id":"GO:0003323","count":23}]},{"hash":"2189957816777920570","title":"Embryonic Morphogenesis and Organ Development","description":"The top GO terms point to broad embryonic development and tissue morphogenesis, spanning facial/palatal development, cartilage and hair follicle morphogenesis, EMT in cardiac cushion, left-right patterning, endocrine system development, pancreatic cell development, and general transcription regulation. This pattern indicates a group of proteins involved in coordinating organogenesis and tissue specification.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":11},{"id":"GO:0006351","count":10},{"id":"GO:0003323","count":10},{"id":"GO:0031069","count":9},{"id":"GO:0003198","count":9}]},{"hash":"742223999120554900","title":"Tissue remodeling and inflammatory response","description":"The GO terms point to connective tissue development/remodeling (lung, bone, nipple morphogenesis), vascular/inflammatory processes (blood coagulation, inflammatory response, monocyte chemotaxis), and developmental contexts, suggesting a cluster of proteins involved in tissue remodeling coupled with immune/inflammatory signaling.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060427","count":20},{"id":"GO:0007190","count":20},{"id":"GO:0032962","count":20},{"id":"GO:0007596","count":20},{"id":"GO:0006954","count":20}]},{"hash":"812950013586423339","title":"Glycine Neurotransmission and Transport","description":"Most top GO terms point to glycine handling\u2014import across the plasma membrane, glycinergic synaptic transmission, and glycine secretion\u2014suggesting a cluster of proteins involved in glycine signaling at synapses. Additional terms related to development and other processes may reflect broader annotations, but the dominant theme is glycine transport and glycinergic neurotransmission, justifying this label.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036233","count":3},{"id":"GO:0070979","count":3},{"id":"GO:0001890","count":3},{"id":"GO:0017148","count":2},{"id":"GO:0021984","count":2}]},{"hash":"2021731479734812206","title":"Rho/Rap GTPase signaling and actin remodeling","description":"This cluster is dominated by GO terms for actin filament network formation and microvillus assembly, together with regulation of Rho and Rap GTPase signaling, pointing to cytoskeletal dynamics driven by small GTPases. While other terms touch differentiation and barrier formation, the strongest signal is cytoskeletal remodeling and GTPase-mediated signaling, supporting a middle-to-high plausible label with moderate confidence due to some off-theme terms.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090630","count":3},{"id":"GO:0007064","count":2},{"id":"GO:0051639","count":2},{"id":"GO:0021707","count":2},{"id":"GO:0035023","count":2}]},{"hash":"340928101076349523","title":"Hormone biosynthesis and reproductive development","description":"The GO terms are dominated by steroid and hormone-related metabolism (testosterone biosynthesis, brassinosteroid biosynthesis, cholesterol and vitamin D catabolism, xenobiotic catabolism) alongside developmental processes such as female gonad and genitalia development and hepatocyte differentiation, suggesting a theme around steroid/hormone metabolism linked to reproductive development. A cell cycle term is present but not central, so the core idea remains hormone metabolism with developmental ties.","confidence":"Medium","size":26,"edges":36,"triangles":13,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1900087","count":8},{"id":"GO:0008585","count":8},{"id":"GO:0019383","count":8},{"id":"GO:0061370","count":8},{"id":"GO:0006707","count":8}]},{"hash":"1040890479209750496","title":"Mitochondrial metabolism and redox stress response","description":"This cluster centers on mitochondrial functions: protein import into the mitochondrial matrix, the TCA cycle, and redox/oxidant detoxification, coupled with apoptotic response under oxidative stress and xenobiotic response. While translation/transcription terms are broad, the prominent mitochondrial/metabolic and redox-related terms strongly tie the proteins to mitochondrial energy metabolism and stress signaling.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0030150","count":2},{"id":"GO:0042493","count":2}]},{"hash":"1572007922316478304","title":"Cell-cycle and gene expression machinery","description":"The terms cluster around core cellular processes: cell division control (meiotic cell cycle, mitotic G1 DNA damage checkpoint) and the machinery of gene expression (formation of translation preinitiation complex, ribosomal subunit biogenesis, nuclear export). While some terms touch development or immune responses, the dominant theme is the maintenance and execution of cell-cycle progression and protein synthesis/nuclear transport.","confidence":"Medium","size":26,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051321","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0043277","count":2},{"id":"GO:0031571","count":2}]},{"hash":"1562018817898179936","title":"Growth factor\u2013mediated inflammatory signaling","description":"This cluster centers on signaling pathways triggered by growth factors (TGF-beta, PDGF) and inflammatory cues (LPS, neutrophil chemotaxis), coordinating ERK and calcium signaling, NFAT/STAT activation, and cell migration. The shared theme is growth factor\u2013driven signaling that modulates immune/inflammatory responses.","confidence":"High","size":26,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":3},{"id":"GO:0030593","count":3},{"id":"GO:0014911","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0036120","count":2}]},{"hash":"1856286000285749090","title":"Eye development and transcriptional regulation","description":"Top GO terms show strong enrichment for transcription by RNA polymerase II and its negative regulation, suggesting a core theme of Pol II\u2013mediated transcriptional control during development. Several eye-related terms (retina development, camera-type eye development, embryonic eye morphogenesis) appear alongside broader morphogenesis terms (lung, vascular wound healing, skeletal muscle), indicating a broader developmental context with a notable emphasis on eye formation. Confidence: Medium","confidence":"Medium","size":26,"edges":287,"triangles":1811,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0000122","count":7},{"id":"GO:0002076","count":6},{"id":"GO:0060041","count":5},{"id":"GO:0060441","count":5}]},{"hash":"853634155140595839","title":"Immune signaling and actin remodeling","description":"This cluster combines innate and adaptive immune terms (innate immune response, adaptive immune response, positive regulation of B cell proliferation) with cytoskeletal dynamics (lamellipodium assembly, ruffle assembly, dendritic spine morphogenesis, barbed-end actin filament capping, positive regulation of GTPase activity) and signaling pathway regulation (regulation of JNK cascade). The overlap suggests proteins that coordinate immune cell activation and migration with actin remodeling, antigen presentation, and related signaling; the presence of transcription regulation hints at broader regulatory roles. Overall, a cohesive theme of immune signaling linked to cytoskeleton remodeling.","confidence":"High","size":26,"edges":46,"triangles":4,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0045087","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0046328","count":3},{"id":"GO:0030890","count":3}]},{"hash":"1094359278991285443","title":"ER-Golgi trafficking with neural and T-cell signaling","description":"This cluster centers on ER-to-Golgi vesicle transport, a key secretory pathway process, and includes terms related to neural plasticity and morphogenesis as well as T-cell signaling and immune responses, suggesting proteins involved in secretory trafficking that interface with neural development and adaptive immunity.","confidence":"Medium","size":26,"edges":26,"triangles":3,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":5},{"id":"GO:0060291","count":5},{"id":"GO:2000172","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0043124","count":4}]},{"hash":"688863340078805348","title":"Embryonic Morphogenesis and EMT Signaling","description":"This cluster is dominated by embryonic morphogenesis processes (axial mesoderm, neural plate, foregut, organ morphogenesis) and cellular remodeling/migration activities (epithelial-to-mesenchymal transition, lamellipodium and focal adhesion assembly). It also shows activation of signaling pathways relevant to development, such as TGF-beta and JAK, which commonly coordinate morphogenesis and EMT. Together, these terms point to a cohesive role in embryonic tissue shaping and cell movement during organ formation.","confidence":"High","size":26,"edges":43,"triangles":77,"max_degree":10,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0048319","count":26},{"id":"GO:0048617","count":26},{"id":"GO:0071560","count":14},{"id":"GO:0042976","count":14},{"id":"GO:0001839","count":14}]},{"hash":"756792403178219127","title":"Eye and Heart GPCR Signaling","description":"Top GO terms show strong enrichment for retina development and phototransduction, heart development, and multiple GPCR signaling pathways (dopamine and adrenergic receptors), including cAMP and PLC cascades and GTPase regulation. This points to a cohesive module of GPCR-mediated signaling active in eye and cardiac tissues, with a xenobiotic response component.","confidence":"High","size":26,"edges":38,"triangles":15,"max_degree":19,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042493","count":24},{"id":"GO:0060041","count":22},{"id":"GO:0007507","count":22},{"id":"GO:0071880","count":22},{"id":"GO:0060158","count":22}]},{"hash":"1608999888168532064","title":"Innate and Adaptive Immune Activation","description":"The cluster features a set of GO terms centered on immune defense: complement activation (lectin pathway), phagocytosis recognition, response to lipopolysaccharide, and adaptive immune response, plus cellular responses to fungal components. These collectively point to immune system engagement against pathogens, with some annotations related to development possibly representing broader or overlapping roles or annotation noise. Overall, the dominant signal is immune activation across innate and adaptive arms.","confidence":"Medium","size":26,"edges":6,"triangles":0,"max_degree":2,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0001502","count":11},{"id":"GO:0071226","count":11},{"id":"GO:0001867","count":9},{"id":"GO:0051873","count":9},{"id":"GO:0060355","count":9}]},{"hash":"1950918217457241287","title":"ERAD and Ubiquitin-Proteasome Proteostasis","description":"The top GO terms point to ubiquitin-dependent protein catabolic processes and ER-associated degradation (ERAD), including K48-linked deubiquitination and unfolded protein maintenance in ERAD. Together these indicate a proteostasis-focused cluster centered on identifying and degrading misfolded proteins via the ubiquitin-proteasome system, with ERAD as a core pathway. Some terms like ascospore formation or righting reflex appear peripheral and do not define the main function. Overall, the cluster appears to reflect protein quality control and degradation pathways rather than a single signaling or transcriptional program.","confidence":"Medium","size":26,"edges":2,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006511","count":7},{"id":"GO:0071108","count":6},{"id":"GO:1904378","count":5},{"id":"GO:0030437","count":4},{"id":"GO:1904293","count":4}]},{"hash":"223650852421070474","title":"Embryonic craniofacial development and ECM remodeling","description":"This cluster centers on extracellular matrix (ECM) remodeling, as shown by collagen catabolic process, ECM disassembly, and proteolysis terms, alongside multiple developmental processes such as cranial skeleton morphogenesis, endochondral ossification, amelogenesis, and midbrain development. The common thread is proteolytic remodeling of the ECM during embryonic development, especially in craniofacial and skeletal contexts, with tooth enamel formation also represented.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0030574","count":6},{"id":"GO:0035987","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0006508","count":5},{"id":"GO:0030901","count":5}]},{"hash":"31666961533191929","title":"Craniofacial bone formation (intramembranous ossification)","description":"These proteins are enriched for collagen fibril organization, cartilage condensation, osteoblast differentiation, and intramembranous ossification, with related craniofacial terms such as roof of mouth development and skin development. This points to a shared role in craniofacial skeletal development via intramembranous ossification; other terms like ventricular septum development or immune-related terms appear less central to the core theme.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":7},{"id":"GO:0007275","count":6},{"id":"GO:0044319","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0060021","count":4}]},{"hash":"1458968641590568148","title":"Proteolysis and Signaling Regulation","description":"Most prominent GO term is proteolysis, with several entries describing regulation of signaling pathways (TGF-beta, Wnt, NF-kappaB). Additional terms point to post-translational processing (deglycosylation) and development-related regulation (meristem identity), suggesting a cluster of proteolytic or processing enzymes that modulate signaling cascades rather than a single pathway. Confidence stems from the clear proteolysis signal and related pathway regulation terms across the cluster, though some terms are broad or mixed across organisms, so keep moderate caution.","confidence":"Medium","size":26,"edges":19,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":9},{"id":"GO:0030512","count":5},{"id":"GO:0006517","count":5},{"id":"GO:0014068","count":5},{"id":"GO:0071560","count":4}]},{"hash":"1557679330287144521","title":"Developmental signaling and morphogenesis","description":"Proteins in this cluster show enrichment for developmental signaling pathways (Wnt, JNK), and morphogenesis processes across tissues (dendritic spine morphogenesis, lens fiber morphogenesis, axial mesoderm formation). While a few terms like social behavior or telomere maintenance are less cohesive, the dominant themes point to signaling-regulated tissue formation and organization.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0043507","count":5},{"id":"GO:0035176","count":5},{"id":"GO:0060997","count":5},{"id":"GO:0048320","count":5},{"id":"GO:0070309","count":5}]},{"hash":"1018864958167561287","title":"Developmental morphogenesis and neural development","description":"The top GO terms center on neuronal migration and neural signaling, along with multiple morphogenesis processes (haltere, anterior head, paramesonephric duct) and actin assembly, indicating a cohesive theme of developmental programs shaping tissue form and neural differentiation.","confidence":"High","size":26,"edges":174,"triangles":448,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0097477","count":26},{"id":"GO:0070527","count":26},{"id":"GO:0021937","count":25},{"id":"GO:0008585","count":25},{"id":"GO:0050859","count":25}]},{"hash":"1704648323394188300","title":"cGMP Signaling and Cardiac Regulation","description":"The cluster centers on cGMP-related signaling: cellular responses to cGMP, cGMP catabolic processes, and regulation of guanylyl cyclase signaling, plus functional links to cardiac muscle activity (hypertrophy and relaxation). The presence of an olfactory perception term may reflect olfactory signaling pathways that involve cGMP, but the dominant theme is cGMP-mediated signaling intertwined with cardiac function. Some terms are marked obsolete, but the core connection remains coherent across the set.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007608","count":15},{"id":"GO:0071321","count":15},{"id":"GO:0097011","count":15},{"id":"GO:0010754","count":15},{"id":"GO:0071560","count":12}]},{"hash":"1604248629187322461","title":"Neuronal GPCR signaling and sensory perception","description":"Strong enrichment for sensory perception (pain, vision), GPCR signaling with cGMP, opsin signaling, and ERK cascade points to neuronal sensory signaling driven by GPCRs. Cocaine-related behavioral response also suggests neural processing; non-neural terms (heart development, macrophage chemotaxis) are less central.","confidence":"Medium","size":26,"edges":89,"triangles":44,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":24},{"id":"GO:0007601","count":24},{"id":"GO:0007507","count":23},{"id":"GO:0007190","count":23},{"id":"GO:0042391","count":23}]},{"hash":"1048602404829207527","title":"GPCR-cAMP Signaling and Metabolic Regulation","description":"The top GO terms point to GPCR-mediated activation of adenylyl cyclase and downstream cAMP signaling, suggesting a central role for GPCR signaling. The presence of energy/metabolism-related terms (electron transport chain, diet-induced thermogenesis) alongside thermoregulation and endocrine/secretory outputs (blood pressure regulation, saliva secretion) indicates a broader metabolic-physiological network coordinated by this pathway. Taken together, the cluster appears to represent a GPCR-cAMP\u2013driven hub linking signaling to metabolic and physiological responses.","confidence":"Medium","size":26,"edges":4,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":24},{"id":"GO:0022900","count":24},{"id":"GO:0010579","count":24},{"id":"GO:0007190","count":23},{"id":"GO:0019233","count":22}]},{"hash":"408517115111375607","title":"Ribosome Biogenesis and Translation","description":"The cluster is dominated by translation-related terms: GO:0006412 (translation), GO:0042254 (ribosome biogenesis), GO:0008033 (tRNA processing), GO:0042274 (ribosomal small subunit biogenesis), and GO:0000055 (ribosomal large subunit export from nucleus). This strongly suggests proteins involved in ribosome assembly and protein synthesis. Some terms also touch on innate immune response and growth regulation, but the core pattern points to ribosome/translation machinery.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0042254","count":5},{"id":"GO:1903833","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0008285","count":4}]},{"hash":"1670696668440108446","title":"Actin Cytoskeleton Remodeling & Signaling","description":"The top GO terms indicate cytoskeletal dynamics and membrane remodeling (e.g., positive regulation of actin filament polymerization; dendritic spine morphogenesis) with accompanying phosphorylation, suggesting a common theme of actin-driven morphogenesis and signaling; a few terms refer to vesicle trafficking and cell-cycle regulation, which are less central but do not overpower the dominant cytoskeletal signal.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003232","count":3},{"id":"GO:0060997","count":3},{"id":"GO:0000011","count":3},{"id":"GO:1903526","count":3},{"id":"GO:0006468","count":3}]},{"hash":"1783010370159068136","title":"Retina and eye morphogenesis with transcription regulation","description":"This cluster is enriched for retina and eye development terms (retina development in camera-type eye, camera-type eye development, embryonic eye morphogenesis) and for transcriptional regulation by RNA polymerase II, indicating proteins that coordinate eye formation with transcription control.","confidence":"High","size":26,"edges":312,"triangles":2315,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":14},{"id":"GO:0060041","count":9},{"id":"GO:0000122","count":9},{"id":"GO:0021983","count":8},{"id":"GO:0035470","count":8}]},{"hash":"2042802351588730739","title":"Drosophila development and cell polarity","description":"The top GO terms point to broad developmental processes in insects, especially Drosophila: follicular epithelium polarity and adhesion during egg chamber development, insect visual primordium formation, and general nervous system and muscle tissue development. A single, cohesive molecular function is not evident; instead, the proteins appear linked to diverse developmental events and tissue organization. Thus the label emphasizes development with a focus on cell polarity and tissue patterning.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007095","count":4},{"id":"GO:0075015","count":3},{"id":"GO:0001744","count":3},{"id":"GO:0042248","count":3},{"id":"GO:0032092","count":3}]},{"hash":"788165430556638312","title":"Cardiac calcium signaling and contraction","description":"The top GO terms cluster around heart contraction, regulation of calcium release from the sarcoplasmic reticulum and ryanodine-sensitive channels, and ER membrane organization, all pointing to calcium handling in cardiac muscle and cardiac conduction. While a few morphogenesis terms appear, the strongest, coherent signal is cardiac muscle function and intracellular calcium signaling.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060047","count":3},{"id":"GO:0060325","count":3},{"id":"GO:0035108","count":3},{"id":"GO:1901846","count":3},{"id":"GO:0060316","count":3}]},{"hash":"1087426104857266815","title":"Innate Immune Defense and Cell Adhesion","description":"The top GO terms point to innate immune processes (innate immune response, defense response to bacterium, complement activation) and cell\u2013cell adhesion (heterophilic and homophilic adhesion), suggesting a cluster focused on immune defense paired with adhesion-mediated cell interactions. Some terms about symbiont entry and a few broader processes may reflect host\u2013pathogen interaction roles or noise, but the dominant theme aligns with innate immunity and adhesion functions.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":14},{"id":"GO:0000187","count":13},{"id":"GO:0032516","count":11},{"id":"GO:0046718","count":11},{"id":"GO:0042742","count":11}]},{"hash":"84541531495438527","title":"MAPK/Rho signaling and Golgi transport in development","description":"This cluster combines signals of MAPK/ERK activation and Rho GTPase pathways with vesicle trafficking processes (Golgi to plasma membrane transport, protein transport), and includes development-related terms (angiogenesis, nervous system development, multicellular organism development, ossification). The convergence of signaling and transport activities in a developmental context suggests a coherent module coordinating signal transduction with membrane trafficking to drive growth and differentiation.","confidence":"High","size":26,"edges":162,"triangles":278,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0006893","count":4},{"id":"GO:0015031","count":4},{"id":"GO:0001525","count":3}]},{"hash":"1748544377164278083","title":"Embryonic organ morphogenesis","description":"The terms show widespread embryonic development and tissue morphogenesis (eye, heart/outflow tract, hindlimb, placenta, habenula, prostate), with a supporting transcription regulation term, suggesting participation in broad developmental programs rather than a single tissue. ","confidence":"High","size":26,"edges":84,"triangles":33,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0048048","count":11},{"id":"GO:2000288","count":10},{"id":"GO:0007507","count":10},{"id":"GO:0021986","count":10}]},{"hash":"1382888661765966268","title":"Embryonic Development and Organogenesis","description":"The cluster is dominated by developmental processes and tissue morphogenesis. Top terms point to patterning (left/right), heart cushion EMT, cartilage morphogenesis, placenta and endocrine system development, and pancreatic cell differentiation, which together indicate a focus on embryonic development and organ formation. Negative regulation of transcription by RNA Pol II suggests gene expression control during these processes. A single term on lipopolysaccharide response may reflect broader signaling cross-talk rather than a core function.","confidence":"Medium","size":26,"edges":6,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0060972","count":6},{"id":"GO:0003198","count":5},{"id":"GO:0060707","count":5},{"id":"GO:0060536","count":5}]},{"hash":"1105463836914021572","title":"Synaptic signaling and spine morphogenesis","description":"This cluster is driven by GO terms centered on neuronal communication and synapse structure, such as protein localization to synapse, dendritic spine morphogenesis, Rho signaling regulation, and opioid receptor signaling, all pointing to synaptic assembly and signaling dynamics. While a few terms touch on non-neuronal processes, the strongest and most frequent themes relate to neuronal connectivity and synaptic regulation. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0070433","count":14},{"id":"GO:0007605","count":13},{"id":"GO:0090557","count":12},{"id":"GO:0046328","count":12},{"id":"GO:0051683","count":11}]},{"hash":"1752945690781996509","title":"Rho/Rac GTPase signaling cluster","description":"The top GO terms are dominated by regulation and activation of Rho family GTPases (Rho, Rac) and related signaling, including GTPase activation and negative regulation of Rac, which points to a cohesive theme around Rho/Rac-mediated signaling and cytoskeletal regulation. Additional terms touch on development of the nervous system and tissues, suggesting these signaling components may have roles in morphogenesis and neural development, with PARylation indicating possible post-translational regulation. Overall, the cluster seems centered on Rho/Rac GTPase signaling with supportive developmental associations.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":8},{"id":"GO:0090630","count":6},{"id":"GO:0070212","count":6},{"id":"GO:0007266","count":6},{"id":"GO:0021510","count":5}]},{"hash":"427236269514474111","title":"Innate Immunity and Vascular Remodeling","description":"This cluster is enriched for innate defense processes (defense response to Gram-positive bacteria and complement activation) together with vascular and extracellular matrix remodeling (blood coagulation, collagen catabolic process, endothelial barrier establishment), suggesting a theme of immune defense linked to tissue integrity and remodeling. Wnt signaling and growth terms appear as ancillary links to developmental/growth pathways but do not redefine the core theme. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":12},{"id":"GO:0000122","count":12},{"id":"GO:0016055","count":11},{"id":"GO:0035264","count":11},{"id":"GO:0007596","count":11}]},{"hash":"2304760640827746556","title":"Embryonic Development and Morphogenesis","description":"The cluster centers on embryonic development and tissue morphogenesis, with terms spanning mesoderm development, left-right patterning, cartilage and hair follicle morphogenesis, placenta/endocrine system development, and organ-specific progenitor differentiation, pointing to a cohesive embryogenesis/morphogenesis theme.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":22},{"id":"GO:0060536","count":21},{"id":"GO:0060972","count":21},{"id":"GO:0060806","count":21},{"id":"GO:0031069","count":21}]},{"hash":"2045798017148566688","title":"Mitochondrial energy transport and dynamics","description":"Dominant GO terms center on mitochondrial energy handling and organelle dynamics\u2014ATP/ADP transport, iron import, membrane potential regulation, and mitochondrial fission\u2014pointing to a coherent mitochondrial metabolism theme; other terms reflect metabolic stress responses that may be secondary.","confidence":"High","size":26,"edges":28,"triangles":29,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060546","count":12},{"id":"GO:0097421","count":11},{"id":"GO:0034198","count":11},{"id":"GO:0048250","count":10},{"id":"GO:0035435","count":10}]},{"hash":"2124801720319748636","title":"Unknown","description":"Top GO terms span immune signaling, metabolic signaling, development, chromatin dynamics, transcription, cell cycle, and cytokine responses, with no single unifying process evident. Because the terms reflect diverse, disparate functions and there is no cohesive theme linking the proteins, a concise representative label cannot be confidently assigned.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0007519","count":3},{"id":"GO:0042766","count":3},{"id":"GO:0043044","count":3}]},{"hash":"893185395792207696","title":"Notch-driven epithelial development","description":"Top GO terms point to Notch signaling and epithelial morphogenesis (Notch receptor processing; negative regulation of Notch signaling; keratinocyte differentiation; palatal shelf morphogenesis), suggesting a core theme of Notch-mediated epithelial development. Some outliers (inflammatory response, LPS biosynthesis) may reflect broader, non-specific signals or noise, but the dominant pattern supports epithelial development governed by Notch. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0006954","count":6},{"id":"GO:0009103","count":6},{"id":"GO:0045746","count":5},{"id":"GO:1902987","count":5}]},{"hash":"468399515242036540","title":"Immune Activation and Tissue Development","description":"The top GO terms show strong signals for immune responses (eosinophil degranulation, neutrophil killing of Gram-negative bacteria, response to LPS, dendritic cell chemotaxis) alongside development and barrier-related terms across multiple tissues (lung, retina, heart, endothelium). This suggests proteins in the cluster participate in immune signaling and broader tissue development or barrier regulation, rather than a single specific function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":23},{"id":"GO:0060427","count":23},{"id":"GO:0070963","count":23},{"id":"GO:0051482","count":23},{"id":"GO:0060041","count":23}]},{"hash":"151556398951698129","title":"Developmental Signaling and Differentiation","description":"This cluster is dominated by GO terms for key developmental signaling pathways (positive regulation of canonical Wnt signaling, Hippo signaling) and differentiation processes (keratinocyte differentiation, placental/embryonic tissue development), along with apoptosis and proliferation regulation. The combination points to roles in tissue development, growth control, and remodeling, with some immune-related responses that can accompany development and tissue homeostasis.","confidence":"High","size":25,"edges":3,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090263","count":16},{"id":"GO:0060044","count":15},{"id":"GO:0030216","count":15},{"id":"GO:0006915","count":15},{"id":"GO:0035329","count":15}]},{"hash":"1423992778141748098","title":"ERAD-Linked Protein Quality Control","description":"This cluster centers on degradation and quality-control pathways, highlighted by ubiquitin-dependent ERAD, unfolded protein response maintenance, and related processing (deglycosylation, sumoylation). Additional terms on vesicle formation, endocytosis, and mitophagy reinforce a theme of protein turnover and trafficking quality control. Some terms (e.g., nucleotide-excision repair) may reflect noise or broader cellular stress roles, but the dominant signal points to ER-associated quality control and turnover.","confidence":"Medium","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":12},{"id":"GO:1905366","count":10},{"id":"GO:1904378","count":10},{"id":"GO:0017085","count":10},{"id":"GO:1900186","count":10}]},{"hash":"84233197817104052","title":"DNA replication and repair cluster","description":"Most terms point to DNA maintenance: replication, repair, recombination, and DNA synthesis, as shown by GO:0006260, GO:0006281, GO:0007131, GO:0071897, and GO:0000732. This indicates the proteins are related to genome integrity and replication processes. A few terms (synaptic potentiation, osteoclast differentiation, camptothecin response) are less central and may reflect multifunctional proteins or annotation noise.","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007131","count":3},{"id":"GO:0006281","count":3},{"id":"GO:0009636","count":3},{"id":"GO:0071897","count":3},{"id":"GO:0006260","count":3}]},{"hash":"856582511316031307","title":"Cardiac conduction and cell junctions","description":"This cluster\u2019s top GO terms center on heart physiology, notably regulation of heart rate by cardiac conduction and desmosome assembly, which points to cardiac tissue cell-cell adhesion and electrical activity. Calcium signaling terms (negative regulation of ER calcium concentration) further support a role in cardiac excitation-contraction coupling. While other terms touch on vesicle trafficking and development (renal vesicle formation, CNS vasculogenesis), the strongest and most coherent signal is heart conduction and intercellular junctions. ","confidence":"Medium","size":25,"edges":142,"triangles":513,"max_degree":17,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0086091","count":13},{"id":"GO:0000011","count":12},{"id":"GO:0002159","count":12},{"id":"GO:0048096","count":12},{"id":"GO:0071255","count":12}]},{"hash":"1064092770197305338","title":"Ribosome biogenesis and translation","description":"The cluster is dominated by GO terms related to ribosome biology and protein synthesis (translation, ribosome biogenesis, ribosomal subunit biogenesis/export, tRNA modification). This points to roles in ribosome assembly, RNA processing, and translation, with only a few secondary terms about stress response or cell cycle; overall, the signature aligns with ribosome biogenesis and translation functions.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0042254","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0007049","count":6},{"id":"GO:0042274","count":5}]},{"hash":"1938988606799490937","title":"Embryonic development and organ patterning","description":"The terms point to broad developmental processes across multiple tissues (somite formation, floor plate, neural crest migration, inner ear and retinal differentiation, lung vasculature, pancreas), with transcription by RNA polymerase II indicating active gene expression programs driving these differentiation events. This suggests a general embryonic patterning/differentiation program rather than a single-tissue function.","confidence":"Medium","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":23},{"id":"GO:0035881","count":18},{"id":"GO:0060426","count":18},{"id":"GO:0033504","count":18},{"id":"GO:0001756","count":18}]},{"hash":"1178742533594289833","title":"Post-transcriptional mRNA processing and translational control","description":"The top GO terms point to RNA maturation and regulation of translation, including mRNA splicing via the spliceosome, mRNA polyadenylation, export, stability under stress, and multiple facets of translation initiation and reinitiation (including viral IRES-dependent initiation). Together they describe a coherent cluster centered on post-transcriptional gene expression regulation, spanning nuclear mRNA processing to cytosolic translational control.","confidence":"High","size":25,"edges":199,"triangles":815,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":15},{"id":"GO:0006378","count":15},{"id":"GO:0045292","count":14},{"id":"GO:0006406","count":13},{"id":"GO:0006446","count":13}]},{"hash":"916528350084054824","title":"Neuronal axon guidance and synapse formation","description":"The top GO terms cluster around ephrin receptor signaling, integrin-mediated adhesion, dendritic spine morphogenesis, CNS projection neuron axonogenesis, retinal ganglion cell axon guidance, and corpus callosum development, indicating involvement in neural wiring and synaptic maturation during brain development. Some terms are less directly related (mesoderm formation, telomere maintenance), but the dominant signals point to CNS axon guidance and synapse formation.","confidence":"High","size":25,"edges":184,"triangles":609,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048013","count":8},{"id":"GO:0033628","count":8},{"id":"GO:0060997","count":8},{"id":"GO:0007205","count":8},{"id":"GO:2001275","count":7}]},{"hash":"1147667067053848504","title":"Chromatin remodeling and epigenetic regulation","description":"Most of the top GO terms point to chromatin remodeling, DNA methylation/imprinting-related regulation, and DNA repair, suggesting a cluster focused on epigenetic control and genome maintenance. While a few terms (axonogenesis, IgA isotype switching, mating-type switching) are peripheral, the dominant signal lies in chromatin-level regulation and genome integrity processes.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006349","count":5},{"id":"GO:0000278","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0043044","count":4},{"id":"GO:0043046","count":4}]},{"hash":"2123090034815795095","title":"Synapse organization and dendritic spine morphogenesis","description":"The set is dominated by GO terms for protein localization to synapse, receptor clustering, and dendritic spine morphogenesis, with supporting roles for Rho and Wnt signaling and protein dephosphorylation, pointing to synaptic assembly and cytoskeletal remodeling; a few terms about endothelial or immune processes are present but likely peripheral to the main theme.","confidence":"High","size":25,"edges":2,"triangles":0,"max_degree":2,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0035418","count":18},{"id":"GO:0043113","count":18},{"id":"GO:2000670","count":18},{"id":"GO:0060997","count":18},{"id":"GO:0008285","count":18}]},{"hash":"1045009025715667921","title":"Neural development and gene regulation","description":"This cluster features GO terms tied to nervous system development (spinal cord, retina) along with gene expression and chromatin regulation (mRNA splicing, histone acetylation), plus cytoskeletal/molecular signaling processes (microtubule movement, GTPase activity) and hypoxia response, suggesting coordinated roles in neural development and its regulation.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0021510","count":5},{"id":"GO:0000398","count":5},{"id":"GO:0043982","count":4},{"id":"GO:0043981","count":4}]},{"hash":"1580216308345202594","title":"Synaptic plasticity and learning","description":"The top GO terms are dominated by neuronal/synaptic functions: dendritic spine morphogenesis, AMPA receptor clustering, synaptic vesicle transport, learning, and regulation of fear, suggesting these proteins cluster around synaptic formation and plasticity. A few terms relate to snoRNA splicing or immune cell homeostasis, which are peripheral to the main neural theme, hence not fully cohesive. Overall, the cluster seems centered on synaptic function and learning, with some outliers.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":4},{"id":"GO:0034247","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0098789","count":2},{"id":"GO:0001782","count":2}]},{"hash":"85048069635939991","title":"Antiviral innate immune signaling","description":"This cluster centers on antiviral defense and immune signaling, with GO terms for cellular response to virus, defense responses to virus and bacterium, innate immune response, adaptive immune response, LPS response, and dexamethasone stimulus, plus positive regulation of STAT tyrosine phosphorylation, indicating JAK-STAT\u2013mediated antiviral/inflammatory signaling and broad immune modulation.","confidence":"High","size":25,"edges":34,"triangles":22,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0098586","count":6},{"id":"GO:0042517","count":6},{"id":"GO:0045071","count":6},{"id":"GO:0042742","count":6},{"id":"GO:0051607","count":5}]},{"hash":"274006090621074972","title":"Caveolin-Mediated Endocytosis and Signaling","description":"This cluster is dominated by caveolin-mediated endocytosis, indicating a membrane-trafficking theme centered on caveolae. Additional GO terms point to membrane lipid regulation (sphingolipid biosynthesis), cell signaling (JNK activity regulation, IL-7 response), and broader cellular processes like centrosome cycle and development (neuronal and mammary/gland contexts). The combination suggests proteins involved in membrane-associated signaling and trafficking with wider roles in proliferation and development, rather than a single highly specific function.","confidence":"Medium","size":25,"edges":82,"triangles":215,"max_degree":24,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0072584","count":24},{"id":"GO:0033598","count":24},{"id":"GO:1990804","count":24},{"id":"GO:0007098","count":24},{"id":"GO:0043506","count":24}]},{"hash":"978308011025376356","title":"Rho-regulated actin dynamics","description":"The cluster\u2019s top GO terms are dominated by regulation of Rho protein signaling and actin cytoskeleton organization, pointing to a shared role in cytoskeleton remodeling governed by Rho pathways. Other terms (calcium homeostasis, infection structure formation, transport, and metabolism) may reflect broader signaling or annotation noise, but the core theme centers on cytoskeletal dynamics linked to Rho signaling.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0030036","count":4},{"id":"GO:0075015","count":3},{"id":"GO:0006874","count":3}]},{"hash":"1874392768668597163","title":"Embryonic Eye Development","description":"The top GO terms center on eye formation, including embryonic eye morphogenesis, camera-type eye development, and lens epithelial cell proliferation, with additional embryonic morphogenesis terms. This points to a cohesive group of proteins involved in vertebrate eye development during embryogenesis, with transcription regulation as a supporting activity.","confidence":"High","size":25,"edges":58,"triangles":19,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0006351","count":8},{"id":"GO:0045654","count":7},{"id":"GO:0001701","count":7},{"id":"GO:0043046","count":7}]},{"hash":"2209261169184822519","title":"Clathrin-dependent endocytosis and actin remodeling","description":"Most terms center on clathrin-mediated endocytosis and vesicle formation (clathrin-dependent endocytosis, clathrin coat assembly, receptor-mediated endocytosis) and actin nucleation regulation (Arp2/3). This suggests the cluster represents proteins coordinating endocytosis with cytoskeletal dynamics; a few terms like apoptotic process are secondary. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034316","count":16},{"id":"GO:2000369","count":10},{"id":"GO:0043547","count":9},{"id":"GO:0060453","count":9},{"id":"GO:1902961","count":9}]},{"hash":"1797312804276606187","title":"Complement activation and tissue remodeling","description":"This cluster is dominated by GO terms for complement activation (classical and lectin pathways), defense responses, and extracellular matrix disassembly/tissue remodeling, with additional links to coagulation. Some terms (midbrain development, transcription regulation) are less aligned, but the core signal points to innate immunity combined with tissue remodeling.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0030901","count":10},{"id":"GO:0001867","count":8},{"id":"GO:0006958","count":8},{"id":"GO:0022617","count":7}]},{"hash":"2302396253362265129","title":"Immune-ECM Interaction and Phagocytosis","description":"The cluster is dominated by GO terms linking immune functions (complement activation, bacterial agglutination, engulfment of apoptotic cells) with extracellular matrix and cell adhesion (collagen fibril organization, cell adhesion), suggesting coordinated immune signaling and ECM interactions. A few RNA processing terms appear as ancillary regulation but do not define the main theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0032026","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0030199","count":6},{"id":"GO:0007155","count":6},{"id":"GO:0048026","count":5}]},{"hash":"1108097821449716208","title":"Unknown","description":"The top terms are highly heterogeneous, spanning mitochondrial processes, steroid/dexamethasone response, viral processes, bacterial biosynthesis and redox activities, with several GO terms marked obsolete. There is no clear single biological theme that ties the proteins together, and some terms are nonspecific or likely misannotations. Because of this lack of a coherent function or pathway enrichment, the cluster cannot be assigned a meaningful, specific label beyond Unknown.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0016032","count":3},{"id":"GO:1902600","count":3},{"id":"GO:0006627","count":3},{"id":"GO:0097171","count":2}]},{"hash":"1405731718989757274","title":"Steroid metabolism and gonadal development","description":"The set is dominated by GO terms for steroid-related metabolism (testosterone biosynthesis, cholesterol and vitamin D catabolism, brassinosteroid biosynthesis) and by developmental processes tied to gonads and genitalia, plus hepatocyte differentiation. While there are some outliers (plant-related brassinosteroids and camphor catabolism), the common thread appears to be hormone/steroid metabolism linked to reproductive development, with detoxification/metabolic remodeling accompanying it.","confidence":"Medium","size":25,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1900087","count":23},{"id":"GO:0008585","count":23},{"id":"GO:0019383","count":23},{"id":"GO:0061370","count":23},{"id":"GO:0006707","count":23}]},{"hash":"1107241794308049992","title":"T Cell Activation and Lymphoid Signaling","description":"The top GO terms cluster around lymphoid immune processes: T cell activation via TCR engagement, NK T cell differentiation, cellular responses to cytokines like interleukin-7, and hematopoiesis. Additional terms involve regulatory signaling pathways (Rho and Ras) and hyaluronan metabolism linked to immune cell migration and tissue remodeling, suggesting a cohesive theme of adaptive immune activation and lymphoid development.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0030212","count":21},{"id":"GO:0002291","count":21},{"id":"GO:0035023","count":19},{"id":"GO:0046580","count":19},{"id":"GO:0001865","count":18}]},{"hash":"972764092032343295","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":7},{"id":"GO:0031954","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0048265","count":6},{"id":"GO:0048549","count":6}]},{"hash":"51758067088887162","title":"Steroid and lipid biosynthesis","description":"The top GO terms are dominated by biosynthetic and metabolic processes for lipids and steroids: retinol metabolism, sphingolipid biosynthesis, testosterone and glucocorticoid biosynthesis, 3-keto-sphinganine metabolic process, and related lipid pathways. This indicates the cluster centers on lipid and steroid production. A couple terms (lung development, response to antibiotic) are less connected but do not outweigh the lipid/steroid theme.","confidence":"High","size":25,"edges":10,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0042572","count":9},{"id":"GO:0030324","count":9},{"id":"GO:0042619","count":9},{"id":"GO:0046677","count":9}]},{"hash":"2170132796714160610","title":"Developmental signaling and tissue morphogenesis","description":"The proteins show broad involvement in nervous system development, vascular and lymphatic formation, skeletal and cartilage development, and collagen organization, with ERK signaling modulation and immune response. This points to a cohesive theme of coordinating tissue morphogenesis across multiple lineages, rather than a single specialized function.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007417","count":15},{"id":"GO:0034116","count":11},{"id":"GO:0070374","count":11},{"id":"GO:0030199","count":11},{"id":"GO:0043536","count":11}]},{"hash":"851572683656377811","title":"Unknown","description":"The terms span hormone synthesis/metabolism, developmental processes across insects and vertebrates, transcription regulation, and various signaling pathways, with no single cohesive function tying all proteins together. Hence no specific, representative label can be assigned.","confidence":"","size":25,"edges":59,"triangles":19,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008585","count":8},{"id":"GO:0061370","count":7},{"id":"GO:0008209","count":7},{"id":"GO:0006355","count":6},{"id":"GO:0055114","count":6}]},{"hash":"9956731169838065","title":"Auditory development and neural signaling","description":"The cluster is dominated by GO terms related to cochlea development and inner ear receptor cell development, pointing to an auditory system focus. Coupled with neural signaling terms (GABA signaling, excitatory postsynaptic potentials, ion transport) and related behaviors (locomotory behavior, conditioned taste aversion), the proteins appear to participate in auditory system development and associated neural signaling pathways. ","confidence":"High","size":25,"edges":12,"triangles":1,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0003009","count":23},{"id":"GO:0007214","count":23},{"id":"GO:0035725","count":23},{"id":"GO:0001661","count":23},{"id":"GO:0071805","count":23}]},{"hash":"1663427669246431544","title":"Embryogenesis and organ morphogenesis","description":"The top GO terms indicate development across multiple organs (retina, heart, gonad, digestive tract, cerebellar signaling) and general developmental regulation (Wnt signaling). This points to a cohesive theme of embryonic organogenesis and morphogenesis rather than a single tissue function, making this label appropriate and representative.","confidence":"High","size":25,"edges":24,"triangles":18,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":24},{"id":"GO:0061551","count":24},{"id":"GO:0007338","count":24},{"id":"GO:0061296","count":23},{"id":"GO:0021937","count":23}]},{"hash":"756163876592599339","title":"Embryonic Craniofacial and Endocrine Development","description":"The top GO terms converge on developmental and morphogenetic processes, particularly craniofacial (palate), cartilage formation, left-right patterning, and endocrine system/pancreatic development, with transcriptional regulation indicating developmental gene networks. This suggests a cohesive theme of embryonic development across craniofacial and endocrine contexts.","confidence":"High","size":25,"edges":49,"triangles":22,"max_degree":14,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0060021","count":15},{"id":"GO:0000122","count":12},{"id":"GO:0006366","count":11},{"id":"GO:0007275","count":10},{"id":"GO:0021759","count":9}]},{"hash":"1469998878589985002","title":"Embryonic development and organogenesis","description":"The top GO terms point to multiple embryonic developmental processes (tissue morphogenesis, left-right patterning, placental and endocrine system development, heart-associated EMT) and organogenesis across different tissues (cartilage, pancreas). While there are general housekeeping terms like splicing and ribosome export, the dominant signal is developmental and morphogenetic, suggesting this cluster groups proteins involved in embryonic development and tissue formation.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":19},{"id":"GO:0060707","count":19},{"id":"GO:0060536","count":19},{"id":"GO:0060806","count":19},{"id":"GO:0035270","count":19}]},{"hash":"1164263708322143767","title":"Embryonic development and tissue morphogenesis","description":"The GO terms are dominated by embryonic morphogenesis and patterning across multiple tissues (cartilage, hair follicles, palate, placenta/mesoderm), including differentiation and developmental processes, suggesting a cluster of proteins broadly involved in embryogenesis rather than a single tissue-specific function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":24},{"id":"GO:0060972","count":24},{"id":"GO:0060806","count":24},{"id":"GO:0031069","count":24},{"id":"GO:0060021","count":24}]},{"hash":"559792746418706554","title":"GPCR-AC Signaling in Cardiovascular and Immune Functions","description":"The top GO terms show strong enrichment for activation of adenylate cyclase and adenylate cyclase-activating GPCR signaling, pointing to GPCR\u2013cAMP pathways as the core function. Supporting terms involve blood pressure regulation, immune cell degranulation, endothelial barrier regulation, and tissue development in lung and retina, suggesting roles in vascular, immune, and tissue remodeling contexts. The electron transport chain term is less specific but may reflect energy-demand aspects of these processes. Overall, the cluster centers on GPCR-mediated adenylate cyclase signaling with cardiovascular and immune implications.","confidence":"Medium","size":25,"edges":4,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":25},{"id":"GO:0045777","count":25},{"id":"GO:0022900","count":25},{"id":"GO:0010579","count":25},{"id":"GO:0043311","count":24}]},{"hash":"1117549686133837806","title":"Immune Response and Organ Development","description":"This cluster is dominated by innate immune-related terms (eosinophil degranulation, neutrophil-mediated killing of Gram-negative bacteria, dendritic cell chemotaxis, response to lipopolysaccharide) and also includes tissue/organ developmental terms (lung connective tissue development, retina development, heart development) and endothelial barrier modulation. The combination suggests proteins involved in both immune signaling and development across multiple tissues, hence the label.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":25},{"id":"GO:0060427","count":25},{"id":"GO:0070963","count":25},{"id":"GO:0051482","count":25},{"id":"GO:0060041","count":25}]},{"hash":"824860338123246019","title":"Multi-tissue development and immune signaling","description":"The cluster\u2019s top GO terms cluster around developmental processes in multiple organs (lung connective tissue, heart, retina) and immune-related activities (eosinophil degranulation regulation, neutrophil killing, dendritic cell chemotaxis), with additional signaling terms. This points to proteins involved in broad developmental signaling across tissues and accompanying immune interactions, rather than a single, narrow function. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007626","count":24},{"id":"GO:0043311","count":22},{"id":"GO:0060427","count":22},{"id":"GO:0070963","count":22},{"id":"GO:0051482","count":22}]},{"hash":"1373645988246839306","title":"Dopaminergic Neural Signaling and Vision","description":"This cluster is dominated by GO terms related to neural communication and perception, especially dopaminergic synaptic transmission, visual perception and learning, and behavioral responses to cocaine, all flagging dopamine\u2011driven neural signaling and sensory processing. A few terms about heart development or immune cell functions appear peripheral and do not define the main theme, which is essentially dopamine-related neural signaling and vision/sensory processing.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":25},{"id":"GO:0070374","count":25},{"id":"GO:0048148","count":25},{"id":"GO:0010759","count":25},{"id":"GO:0019233","count":25}]},{"hash":"1873342569794282481","title":"Mechanotransduction and Calcium Signaling","description":"The cluster\u2019s top GO terms cluster around sensing and responding to mechanical cues (cellular response to mechanical stimulus; detection of mechanical stimulus involved in sensory perception of pain) and calcium handling (calcium ion import across plasma membrane; positive regulation of membrane depolarization during cardiac action potential). This points to a mechanotransduction theme with calcium signaling as a central mediator. Other terms (GPCR signaling, NOD2 pathway, vitamin D response, developmental processes) appear more peripheral, but the mechanical/calcium axis is the strongest shared thread. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0070431","count":3},{"id":"GO:0060843","count":3},{"id":"GO:1900827","count":3},{"id":"GO:0050966","count":3}]},{"hash":"1787031054444776881","title":"RNA Pol II Transcriptional Regulation and Stress Signaling","description":"The cluster is dominated by GO terms for transcription by RNA polymerase II and DNA-templated transcription, with additional links to circadian regulation of gene expression and responses to estradiol and xenobiotic stimuli, plus ER stress\u2013associated apoptotic signaling. This suggests a coherent group of proteins involved in transcriptional regulation that integrates hormonal and stress signals to modulate gene expression.","confidence":"High","size":24,"edges":228,"triangles":1219,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0006351","count":9},{"id":"GO:0045872","count":8},{"id":"GO:0032922","count":8},{"id":"GO:0043433","count":8}]},{"hash":"1603583851940523549","title":"Organismal Development Across Tissues","description":"The top GO terms point to broad developmental programs across multiple tissues and lineages: eye/visual system development, heart development, Schwann cell development, axonogenesis, angiogenesis, and myoblast fusion, with additional signals related to cell cycle and phosphorylation that support differentiation. This suggests a cohesive theme of tissue-specific development and differentiation rather than a single pathway, hence a label capturing multisystem developmental processes.","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":15},{"id":"GO:0007601","count":14},{"id":"GO:0007507","count":13},{"id":"GO:0014044","count":13},{"id":"GO:0010800","count":13}]},{"hash":"1842630194749480043","title":"Transmembrane Transport of Nutrients and Xenobiotics","description":"This cluster centers on diverse transmembrane transport activities across membranes, including xenobiotics, vitamins, various sugars (arabinose, fucose), ions (sodium, phosphate), and nitrate-related processes, suggesting a group of membrane transporters and permeases handling a range of substrates.","confidence":"High","size":24,"edges":50,"triangles":112,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006855","count":18},{"id":"GO:0035461","count":18},{"id":"GO:0042891","count":15},{"id":"GO:0035435","count":11},{"id":"GO:0042128","count":11}]},{"hash":"1741482935249588869","title":"Cardiovascular calcium signaling and coagulation","description":"This cluster shows a strong aggregation of terms related to calcium signaling (calcium modulating pathway, calcium ion transport, adenylate cyclase activation) and heart-related processes (heart development, regulation of heart rate), complemented by coagulation/fibrinolysis terms (blood coagulation, fibrinolysis, negative regulation of fibrinolysis). This suggests a shared functional theme around calcium-dependent cardiovascular signaling and vascular/hemostatic regulation. The presence of astrocyte activation is less directly tied but may reflect broader signaling networks; overall the cardiovascular-coagulation axis best matches the data.","confidence":"Medium","size":24,"edges":21,"triangles":0,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007223","count":5},{"id":"GO:0006469","count":5},{"id":"GO:0051918","count":5},{"id":"GO:0007596","count":5},{"id":"GO:0042730","count":5}]},{"hash":"2261173813903533856","title":"Neural development and synaptic signaling","description":"The cluster centers on neuronal differentiation and signaling processes: regulation of neuron maturation, auditory receptor morphogenesis, nerve branching, evoked neurotransmitter secretion, filopodium/neurite outgrowth, GPCR signaling, and leading-edge localization, suggesting a cohesive neural development and synaptic function theme (with one outlier immune term).","confidence":"Medium","size":24,"edges":42,"triangles":31,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042088","count":24},{"id":"GO:0014041","count":24},{"id":"GO:0007186","count":24},{"id":"GO:0071260","count":24},{"id":"GO:0002093","count":23}]},{"hash":"983073010570042477","title":"Oxidative Stress Detoxification and Metabolic Response","description":"The top GO terms cluster around glutathione-mediated detoxification and cellular oxidant detoxification, indicating redox homeostasis and detox pathways. Additional terms such as response to toxic substances, prostaglandin biosynthesis, and nucleotide-excision repair support a broader stress-adaptation program, including inflammation signaling and DNA repair, complemented by starvation- and amino-acid\u2013related metabolic processes.","confidence":"High","size":24,"edges":213,"triangles":1331,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":20},{"id":"GO:0006749","count":18},{"id":"GO:0001516","count":18},{"id":"GO:0006289","count":18},{"id":"GO:0042594","count":18}]},{"hash":"244223837928807964","title":"Mitochondrial Energy Metabolism and Insulin Signaling","description":"GO terms point to mitochondria-centric energy metabolism and metabolic signaling: ATP/ADP transport, membrane potential regulation and fission, plus insulin/fatty acid related responses and glucose-stimulated insulin regulation.","confidence":"High","size":24,"edges":9,"triangles":2,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032869","count":12},{"id":"GO:0070542","count":11},{"id":"GO:0061179","count":10},{"id":"GO:0048250","count":9},{"id":"GO:0035435","count":9}]},{"hash":"2168714041250047975","title":"Leukocyte migration and activation signaling","description":"The set centers on immune cell movement and activation: neutrophil chemotaxis, myeloid dendritic cell chemotaxis, CD8-positive T cell proliferation, integrin activation, GTPase activation, and ERK cascade signaling. Together these indicate recruitment, adhesion, and signaling in leukocytes during immune responses. Some terms reflect broader cell migration, but the dominant pattern is immune cell trafficking and activation.","confidence":"High","size":24,"edges":121,"triangles":335,"max_degree":19,"top_function":"wound healing","top_go_terms":[{"id":"GO:0043552","count":18},{"id":"GO:0090630","count":16},{"id":"GO:0030593","count":16},{"id":"GO:0070374","count":15},{"id":"GO:0033622","count":15}]},{"hash":"179302423292468924","title":"Developmental signaling and organogenesis","description":"The top GO terms point to developmental processes across several tissues (bone/osteoblast fate, bone and heart development, uterus development) and to signaling pathways (JNK cascade, GTPase regulation, actin cytoskeleton remodeling), plus immune activation, suggesting a cluster of proteins involved in developmental signaling and morphogenesis rather than a single tissue-specific function.","confidence":"Medium","size":24,"edges":34,"triangles":12,"max_degree":21,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046328","count":5},{"id":"GO:0002051","count":4},{"id":"GO:0060065","count":4},{"id":"GO:0060348","count":4},{"id":"GO:0002250","count":4}]},{"hash":"2045129003152048601","title":"Steroid biosynthesis and female reproductive development","description":"The cluster is dominated by GO terms for lipid/hormone biosynthesis and metabolism (prostaglandin, testosterone, cholesterol, vitamin D, brassinosteroid) and female reproductive development (female gonad and genitalia development). This points to a cohesive theme of steroid/lipid hormone production and signaling with relevance to female reproductive biology, with some ancillary xenobiotic/camphor catabolic processes that are linked to lipid metabolism. ","confidence":"High","size":24,"edges":236,"triangles":1318,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":21},{"id":"GO:1900087","count":19},{"id":"GO:0008585","count":19},{"id":"GO:0019383","count":19},{"id":"GO:0061370","count":19}]},{"hash":"953621108213301168","title":"Xenobiotic and Nutrient Transporters","description":"These proteins are annotated with multiple transmembrane transport GO terms covering xenobiotic and vitamin transport, various ions (K+, Na+, phosphate), nitrate assimilation, and sugar transport (D-xylose, arabinose, fructose). The clustering of transport-related functions indicates a cohesive group of membrane transporters handling diverse substrates, from xenobiotics to nutrients.","confidence":"High","size":24,"edges":70,"triangles":47,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":24},{"id":"GO:0006855","count":24},{"id":"GO:0042908","count":21},{"id":"GO:0071805","count":21},{"id":"GO:0035435","count":19}]},{"hash":"376447400938231123","title":"Plant innate immunity and cell cycle regulation","description":"The top GO terms point to innate immune and defense responses to viruses, indicating an immunity-focused theme. At the same time, mitotic cell cycle and cell division terms show involvement in cell cycle control. Some terms also reflect plant-specific signaling and stress responses (cytokinin/gibberellin pathways, cadmium response), suggesting a broader plant stress context where immunity and growth regulation intersect. Overall, the cluster seems best described as plant innate immune and cell cycle\u2013related processes.","confidence":"High","size":24,"edges":27,"triangles":0,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0051291","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0051607","count":6},{"id":"GO:0000278","count":6}]},{"hash":"21264672980255021","title":"Vesicle trafficking and epithelial development","description":"This cluster shows a cohesion around vesicle-related processes (vacuole inheritance, Cvt vesicle assembly) together with epithelial and organogenesis-related terms (desmosome assembly, ectoderm development, CNS vasculogenesis, renal vesicle formation). Although the GO terms span multiple areas, the combination suggests a theme where intracellular trafficking interfaces with tissue morphogenesis and epidermal/epithelial organization. Confidence is Medium.","confidence":"Medium","size":24,"edges":254,"triangles":1585,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000011","count":13},{"id":"GO:0002159","count":13},{"id":"GO:0048096","count":13},{"id":"GO:0071255","count":13},{"id":"GO:0022009","count":13}]},{"hash":"156398606625223307","title":"Cytoskeleton remodeling and endocytosis","description":"This cluster is enriched for endocytosis, actin cytoskeleton reorganization, filopodium assembly, and small GTPase signaling, with additional hints of cell polarity and spreading. The convergence of endocytic processes and GTPase-driven cytoskeletal dynamics suggests a common theme of cytoskeletal remodeling coordinated with membrane trafficking and signaling.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006897","count":8},{"id":"GO:0043552","count":7},{"id":"GO:1900026","count":7},{"id":"GO:0090263","count":7},{"id":"GO:0046847","count":7}]},{"hash":"1266123918136015401","title":"Lipid metabolism and membrane signaling","description":"The terms cluster around cholesterol biosynthesis regulation (SREBP pathway, negative regulation of cholesterol biosynthetic process) and related membrane signaling (PKC), with supporting connections to ER-associated degradation and mitochondrial stress, suggesting a unifying theme of lipid homeostasis and membrane signaling.","confidence":"Medium","size":24,"edges":83,"triangles":186,"max_degree":22,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0030433","count":7},{"id":"GO:0022617","count":6},{"id":"GO:0032933","count":6},{"id":"GO:0070528","count":6},{"id":"GO:0000001","count":6}]},{"hash":"477550629967808795","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0043547","count":8},{"id":"GO:0070262","count":7},{"id":"GO:0051028","count":7},{"id":"GO:0038202","count":7},{"id":"GO:0051301","count":6}]},{"hash":"1425904132545002534","title":"Chromosome cohesion and spindle dynamics","description":"The top GO terms point strongly to chromosome organization and segregation (meiotic sister chromatid cohesion at centromeres, establishment of protein localization to chromosomes, spindle orientation checkpoint signaling) plus cytoskeletal changes (septin ring disassembly) and related protein localization control, with some broader signaling roles. This suggests a cohesive theme around chromosome dynamics during cell division, with auxiliary localization and signaling aspects.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0051754","count":10},{"id":"GO:0051388","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0090005","count":5},{"id":"GO:0070199","count":5}]},{"hash":"2124954675086189715","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":9},{"id":"GO:0000278","count":8},{"id":"GO:0045444","count":8},{"id":"GO:0071456","count":7},{"id":"GO:0000447","count":7}]},{"hash":"680109640059508513","title":"Nucleocytoplasmic transport and ribosome export","description":"Top GO terms show ribosomal subunit and mRNA export from the nucleus and nuclear pore complex assembly, pointing to a nucleocytoplasmic transport/ribosome biogenesis module. The presence of cell cycle/kinetochore-related terms suggests a tie to cell division, but the core connection is nuclear-cytoplasmic transport and ribosome export. ","confidence":"High","size":24,"edges":274,"triangles":1980,"max_degree":23,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000055","count":9},{"id":"GO:0006656","count":6},{"id":"GO:0006406","count":6},{"id":"GO:0000056","count":6},{"id":"GO:0051301","count":5}]},{"hash":"110172610331493496","title":"Ribosome Biogenesis and Translation","description":"Most top terms cluster around ribosome biology: translation, ribosome biogenesis, large subunit assembly, and rRNA maturation. The proteins are likely involved in ribosome production and cytoplasmic translation, with only a minor, incidental signal for endothelial apoptosis. Thus, the name reflects the dominant ribosome-related functions.","confidence":"High","size":24,"edges":89,"triangles":212,"max_degree":13,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0042254","count":7},{"id":"GO:0000027","count":5},{"id":"GO:0031167","count":4},{"id":"GO:1902626","count":4}]},{"hash":"1891766177120617286","title":"Spliceosome-regulated mRNA splicing and processing","description":"The top GO terms point to spliceosome-mediated regulation of mRNA splicing and related post-transcriptional processes (stability, export, and poly(A) tail regulation). This suggests proteins in this cluster function together in mRNA maturation and quality control.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":24},{"id":"GO:0000381","count":20},{"id":"GO:0048026","count":16},{"id":"GO:0031047","count":16},{"id":"GO:0048255","count":16}]},{"hash":"32304085818804678","title":"cGMP and cAMP signaling in phototransduction","description":"This cluster is dominated by GO terms for cyclic nucleotide signaling: receptor guanylyl cyclase signaling, cGMP and cAMP biosynthesis, and intracellular signal transduction, with additional terms for blue light signaling and hypoxia detection. Together these suggest a coherent theme of second-messenger signaling in sensory pathways (notably phototransduction) and downstream transcriptional regulation.","confidence":"High","size":24,"edges":5,"triangles":2,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007168","count":10},{"id":"GO:0006355","count":9},{"id":"GO:0070483","count":8},{"id":"GO:1900194","count":8},{"id":"GO:0006171","count":8}]},{"hash":"638305803817891061","title":"mRNA Splicing and Translational Initiation","description":"These proteins cluster around RNA processing and translation control: spliceosome-mediated mRNA splicing, regulation and initiation of translation (including preinitiation complex formation and reinitiation), and stress-related mRNA stability, with viral translation initiation terms supporting a shared theme of RNA maturation and start of protein synthesis. The network terms point to a cohesive module rather than unrelated functions.","confidence":"High","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":12},{"id":"GO:0002188","count":12},{"id":"GO:0001731","count":12},{"id":"GO:0010610","count":11},{"id":"GO:0006376","count":11}]},{"hash":"1738841956932239541","title":"Leukocyte adhesion and activation with phagocytosis","description":"Cluster centers on leukocyte interactions and immune activation, via cell\u2013cell adhesion, phagocytosis, B cell signaling, and complement pathways; the nervous-system terms may reflect microglial roles in CNS synapse remodeling. Name reflects adhesion/activation with phagocytic immune functions.","confidence":"High","size":24,"edges":61,"triangles":19,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007156","count":14},{"id":"GO:0007157","count":14},{"id":"GO:0006911","count":12},{"id":"GO:0006910","count":12},{"id":"GO:0007399","count":12}]},{"hash":"36588858202622049","title":"Neural development and transcriptional regulation","description":"The top GO terms point to transcriptional control (DNA-templated transcription, gene expression) and neural development (neuron development, nervous system development, cerebellar precursor regulation), with SMAD signaling. The hair follicle maturation and lymphocyte homeostasis terms may reflect broader developmental roles rather than a single tissue-specific function. Overall, the cluster appears to capture proteins tied to neural development and transcriptional regulation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0048666","count":3},{"id":"GO:0070207","count":3},{"id":"GO:0048820","count":2},{"id":"GO:0010467","count":2}]},{"hash":"1310209375624763223","title":"Mitochondrial energy metabolism and host defense","description":"The top GO terms cluster around mitochondrial energy production (electron transport chain) and antimicrobial/host defense activities (defense response to bacterium, peptidoglycan catabolic process), with some additional signals that may reflect broader cellular signaling (viral release, pain/blood pressure regulation). This suggests a theme of energy metabolism linked to innate immune interactions, justifying a combined label.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":11},{"id":"GO:0051482","count":9},{"id":"GO:0007626","count":9},{"id":"GO:0019835","count":9},{"id":"GO:0016998","count":9}]},{"hash":"163790680648805672","title":"Tissue-Specific Developmental Transcription Regulation","description":"This cluster centers on development across multiple tissues (retina, spinal cord, cortex, pancreas, muscle) with a strong signal for transcriptional regulation by RNA polymerase II, including both activation and negative regulation, suggesting coordinated transcriptional control of diverse differentiation programs.","confidence":"High","size":24,"edges":275,"triangles":2002,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0060041","count":7},{"id":"GO:0035914","count":7},{"id":"GO:0021530","count":7},{"id":"GO:0021520","count":7}]},{"hash":"963722662898875585","title":"Cytoskeletal remodeling and signaling in development and immunity","description":"This cluster centers on actin cytoskeleton dynamics (actin cytoskeleton organization, filopodium assembly, substrate adhesion-dependent cell spreading) coupled with various signaling pathways (insulin receptor signaling, interleukin-7 response) and immune/developmental processes (innate immune response, NK T differentiation, heart development). The recurring theme appears to be how cytoskeletal remodeling supports diverse signaling in development, immune function, and related cellular processes, with additional hints from synaptic plasticity and apoptosis. ","confidence":"Medium","size":24,"edges":36,"triangles":0,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":20},{"id":"GO:1900026","count":20},{"id":"GO:0001865","count":19},{"id":"GO:0098761","count":19},{"id":"GO:0008286","count":19}]},{"hash":"577401304442582390","title":"Cardiac EC coupling and conduction regulation","description":"Based on the strong enrichment for calcium handling and electrical-conduction GO terms (calcium release from the sarcoplasmic reticulum, regulation of cardiac and Purkinje/AV/node action potentials, and catecholamine/caffeine responses), the cluster seems to center on cardiac excitation-contraction coupling and conduction. A skin development term appears as a minor outlier but does not alter the core cardiac theme.","confidence":"High","size":24,"edges":44,"triangles":5,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010881","count":12},{"id":"GO:0043588","count":12},{"id":"GO:0086029","count":12},{"id":"GO:0098904","count":12},{"id":"GO:0071313","count":12}]},{"hash":"1449670198647163368","title":"Neuronal development and synapse organization","description":"The cluster is dominated by neural-related GO terms: nervous system development, positive regulation of synapse assembly, and both homophilic/heterophilic cell-cell adhesion, plus serotonergic neuron axon guidance and sensory perception of sound. This points to roles in neuronal development, synapse formation/organization, and neural connectivity. Some outliers (bone maturation, marginal zone B cell differentiation) exist but do not override the primary neural theme.","confidence":"High","size":24,"edges":27,"triangles":0,"max_degree":14,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0007399","count":21},{"id":"GO:0051965","count":21},{"id":"GO:0007156","count":21},{"id":"GO:0007157","count":21},{"id":"GO:0043931","count":21}]},{"hash":"252465439097873328","title":"Cell Cycle Regulation and Mechanotransduction","description":"This cluster is dominated by cell cycle-related terms (centrosome cycle, CDK activity regulation, cell cycle, protein dephosphorylation) and mechanotransduction-related terms (cellular response to mechanical stimulus, response to muscle stretch, cell migration). While a couple of terms like mRNA processing and glucose-insensitive regulation are present, the core grouping centers on how cells coordinate division with mechanical cues.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0007098","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0035994","count":2}]},{"hash":"284106814695177873","title":"Signaling and differentiation regulators","description":"These proteins map to multiple signaling pathways (Wnt, NOD2), regulatory processes (ubiquitination, SNARE assembly), vesicle trafficking (pinocytosis), and differentiation contexts (oligodendrocyte, venous endothelial), plus mechanotransduction. There is no single dominant function, but they collectively regulate signaling and differentiation processes.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":6},{"id":"GO:0016055","count":6},{"id":"GO:0045736","count":6},{"id":"GO:0048549","count":6},{"id":"GO:0035544","count":6}]},{"hash":"466107578059115505","title":"Steroid Hormone and Lipid Biosynthesis Network","description":"Most top terms cluster around biosynthesis of steroids (testosterone, glucocorticoids) and complex lipids (sphingolipids, very long-chain fatty acids, poly-hydroxybutyrate), suggesting a cohesive function in lipid and steroid metabolism. A transcription regulation term and a lung development term add context but do not override the lipid/steroid biosynthesis theme. Hence, the cluster likely represents a lipid and steroid biosynthesis network, with a possible transcriptional coordination component.","confidence":"Medium","size":24,"edges":222,"triangles":1098,"max_degree":23,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":20},{"id":"GO:0006729","count":16},{"id":"GO:0061370","count":16},{"id":"GO:0006666","count":16},{"id":"GO:0030148","count":16}]},{"hash":"526131974930237920","title":"Organogenesis and Developmental Signaling","description":"The top GO terms cluster around morphogenesis and development across multiple organ systems\u2014heart, retina, digestive tract, pancreas, gonads, pituitary\u2014with additional neural precursor signaling and regulation of Wnt signaling, indicating a broad developmental/tissue-patterning role rather than a single specific function.","confidence":"High","size":24,"edges":18,"triangles":3,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0061296","count":24},{"id":"GO:0021937","count":24},{"id":"GO:0008585","count":24},{"id":"GO:2000288","count":24},{"id":"GO:0030111","count":24}]},{"hash":"1722906602237563137","title":"Mitotic Progression and Proliferation","description":"The top GO terms point to regulation of CDK activity, DNA-templated transcription, and key cell-cycle transitions (G1/S, G2/M), plus mitotic spindle dynamics and mitotic re-entry, all indicating coordinated control of mitosis and cell proliferation. Some terms relate to proliferation in a tissue context, but the core theme is mitotic progression and growth.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045737","count":7},{"id":"GO:0006351","count":6},{"id":"GO:0000082","count":5},{"id":"GO:0046626","count":5},{"id":"GO:0016049","count":5}]},{"hash":"2248700902183909319","title":"Developmental signaling with coagulation and innate immunity","description":"The top GO terms show developmental roles (Wnt signaling; midbrain and biomineral tissue development) alongside coagulation and immune-related terms (blood coagulation, Factor XII activation, complement activation pathways, response to lipopolysaccharide). This mix suggests a theme where developmental signaling interfaces with vascular/immune functions, rather than a single narrow process.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0016055","count":7},{"id":"GO:0006958","count":7},{"id":"GO:0007596","count":7},{"id":"GO:0031214","count":7}]},{"hash":"429298554042857287","title":"Thermo-nociception and GPCR signaling cluster","description":"The top GO terms show a strong emphasis on temperature-related responses and pain perception (sensory perception of pain, cellular response to temperature stimulus, diet-induced thermogenesis) along with GPCR-mediated signaling (adenylate cyclase-activating GPCR pathway). This points to a coherent theme of temperature/pain sensing intertwined with GPCR signaling, despite a few outlier terms that may reflect broader tissue/immune roles.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":16},{"id":"GO:0002024","count":16},{"id":"GO:0071502","count":16},{"id":"GO:0045777","count":14},{"id":"GO:0008542","count":14}]},{"hash":"273575072067218571","title":"Unknown","description":"The GO terms span spermatid and heart development, fungal sporulation, vesicle and intracellular transport, and various signaling processes, with no single cohesive function tying all 24 proteins together. The absence of edges or connected components (Edges 0, Triangles 0, Max Degree 0) further suggests there is no shared pathway or process, making a concise, representative label inappropriate. Therefore, the cluster is best described as Unknown.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0060048","count":3},{"id":"GO:0010796","count":3}]},{"hash":"1749463447156422222","title":"Neurodevelopment and tissue morphogenesis","description":"The top GO terms cluster around development, especially nervous system formation (spinal cord development, CNS morphogenesis, multicellular organism development) with additional skin and labyrinthine vascular development. Occasional terms for microtubule-based movement and transcription reflect core cellular processes underlying morphogenesis. Overall, the cluster appears to reflect neurodevelopment and broader tissue morphogenesis.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0021510","count":4},{"id":"GO:0045792","count":4},{"id":"GO:0060716","count":3},{"id":"GO:0021551","count":3}]},{"hash":"2115565075385348719","title":"Skeletal and cardiovascular development with cell adhesion","description":"Most terms cluster around bone formation and skeletal development (bone trabecula formation, skeletal system development, osteoblast differentiation) and vascular/heart development (endothelial adhesion, angiogenesis regulation, ventricular septum development, blood coagulation) with a focus on cell\u2013ECM adhesion (integrin-mediated adhesion). This suggests proteins involved in coordinated skeletal and cardiovascular development mediated by adhesion and extracellular matrix interactions.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0007160","count":9},{"id":"GO:2001027","count":8},{"id":"GO:0016525","count":8},{"id":"GO:0060346","count":7},{"id":"GO:0001501","count":7}]},{"hash":"1685874144262472143","title":"Neural signaling and sensory perception","description":"The top GO terms point to neuronal communication (GABA signaling; EPSP) and ion transport (Na+, K+), combined with sensory and behavioral processes (taste detection, conditioned taste aversion, locomotion, phototaxis, lateral line development). This suggests a cohesive theme of neural signaling driving sensory perception and motor responses, likely in an aquatic vertebrate context. ","confidence":"High","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007214","count":24},{"id":"GO:0035725","count":24},{"id":"GO:0001661","count":24},{"id":"GO:0071805","count":24},{"id":"GO:0007626","count":24}]},{"hash":"1153953811798215173","title":"Neural signaling and sensory processing","description":"The majority of top GO terms point to neural signaling and sensory processing, including dopaminergic synaptic transmission, visual perception and learning, pain perception, and behavioral response to cocaine, with a supporting role for ERK signaling. While there are some outliers (heart development, immune degranulation), the dominant pattern is neural/sensory function.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":24},{"id":"GO:0070374","count":24},{"id":"GO:0048148","count":24},{"id":"GO:0010759","count":24},{"id":"GO:0019233","count":24}]},{"hash":"219160827026417770","title":"Embryonic and Placental Morphogenesis","description":"The top GO terms cluster around developmental processes such as embryonic development, placental and endocrine system development, left-right patterning, cartilage morphogenesis, and EMT events, with SMAD signaling tying these pathways together. This points to a cohesive theme of organogenesis and placental tissue differentiation, rather than a single isolated function.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0003323","count":5},{"id":"GO:0060707","count":5},{"id":"GO:0060536","count":4},{"id":"GO:0060972","count":4}]},{"hash":"1666121432652749348","title":"Innate Immune Response","description":"This cluster is dominated by GO terms describing innate immunity and responses to bacterial components (e.g., cellular response to lipopolysaccharide, defense response to Gram-positive bacteria, innate immune response). While there are a few neural development and cytoskeletal terms present, the immune-related functions are clearly the most representative signal for the cluster. Confidence: Medium","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":4},{"id":"GO:0046827","count":4},{"id":"GO:0009826","count":4},{"id":"GO:0050830","count":3},{"id":"GO:0045087","count":3}]},{"hash":"1593922671596550168","title":"Regulated neural morphogenesis and vascular signaling","description":"The top GO terms cluster around neural development and signaling: dendrite morphogenesis, protein localization to synapse, and positive regulation of Wnt signaling, along with positive regulation of angiogenesis. While telomere maintenance/capping and defense-related terms appear, the dominant theme is coordinated signaling and morphogenesis in neural and vascular contexts, suggesting a developmental signaling cluster with some ancillary regulation of cellular processes. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0032212","count":4},{"id":"GO:0048813","count":4},{"id":"GO:0090263","count":4},{"id":"GO:0045071","count":4},{"id":"GO:1904355","count":4}]},{"hash":"421192403967265209","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":3},{"id":"GO:0009240","count":2},{"id":"GO:0071544","count":2},{"id":"GO:0034656","count":2},{"id":"GO:1901911","count":2}]},{"hash":"1589513907631288324","title":"Actin Cytoskeleton Remodeling and Cell Polarity","description":"The top GO terms foreground actin dynamics\u2014nucleation, crosslinking, microspike assembly, and cortical patch localization\u2014as well as processes governing cell shape and polarity, including Rho signaling. Immune-related terms such as innate immune response and IL-2 production may reflect actin-driven remodeling during immune activation. Overall, the cluster centers on actin-based remodeling and cell polarity with associated membrane remodeling.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900042","count":3},{"id":"GO:0051764","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0030035","count":3},{"id":"GO:0071963","count":3}]},{"hash":"698790397544048147","title":"Embryonic development and morphogenesis","description":"This cluster is dominated by GO terms tied to embryonic patterning and tissue morphogenesis, notably cartilage morphogenesis, left/right pattern formation, and EMT-related processes in heart development, along with several organ developmental terms (endocrine pancreas, placenta). While some terms relate to general gene regulation, the strongest signals converge on embryonic tissue formation and morphogenesis, suggesting proteins function together in developmental patterning and organogenesis.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":22},{"id":"GO:0060972","count":22},{"id":"GO:1903026","count":22},{"id":"GO:0000055","count":22},{"id":"GO:0060806","count":22}]},{"hash":"2008076094662199251","title":"Proteostasis via ubiquitin-ERAD and autophagy","description":"This cluster centers on ubiquitin-dependent ERAD and broad proteostasis networks, including sumoylation, autoubiquitination, and deubiquitination, as well as autophagic processes like aggrephagy and piecemeal microautophagy. The repeated emphasis on protein quality control, ER-associated degradation, and vesicle-related autophagy suggests a cohesive role in managing misfolded or aggregated proteins, particularly under stress conditions (e.g., insecticide exposure, TNF signaling). ","confidence":"High","size":23,"edges":132,"triangles":541,"max_degree":19,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":8},{"id":"GO:0016925","count":7},{"id":"GO:0035973","count":6},{"id":"GO:1903265","count":6},{"id":"GO:0051865","count":6}]},{"hash":"584537242992708749","title":"DNA replication and repair","description":"The cluster is enriched for GO terms tied to DNA-templated replication, DNA repair, and DNA catabolic processes, with supporting signals from cell-cycle regulation. While a few outlier terms touch on renal water transport, xenobiotic response, or migration, the dominant terms indicate genome maintenance and replication as the core function of the protein set.","confidence":"High","size":23,"edges":7,"triangles":0,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006261","count":6},{"id":"GO:0006281","count":6},{"id":"GO:0014912","count":4},{"id":"GO:2001153","count":4},{"id":"GO:0006308","count":4}]},{"hash":"499257873081572085","title":"DNA Transcription Regulation and Development","description":"Most represented terms are DNA-templated transcription (GO:0006351) and regulation of DNA-templated transcription (GO:0006355), with related developmental processes such as antennal development (GO:0007469) and cell morphogenesis (GO:0000902). The presence of apoptosis, cellular response to gamma radiation, and Golgi inheritance suggests broader cellular regulation, but the central theme appears to be regulation of gene expression during development rather than a single, unified pathway.","confidence":"Medium","size":23,"edges":22,"triangles":0,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0007469","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006915","count":2}]},{"hash":"958948462779881461","title":"Unknown","description":"The cluster shows a mix of translation-related processes (translation, mRNA processing, prolyl-tRNA aminoacylation, translational fidelity regulation) together with membrane transport and several disparate terms (symbiont entry into host cell, cold response, oxidation-reduction). There is no single dominant function tying these terms together, so a coherent label is not warranted.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902600","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0009409","count":2}]},{"hash":"1847829771959888777","title":"Neural dendrite morphogenesis and calcium signaling","description":"This cluster is enriched for neural-related terms such as dendrite development and morphogenesis, ephrin receptor signaling, neuronal stem cell maintenance, and calcium ion transport, suggesting a cohesive module of neural development and signaling tied to dendrite formation and calcium signaling; a few plant-specific terms likely reflect annotation noise. ","confidence":"High","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0036292","count":4},{"id":"GO:0070588","count":4},{"id":"GO:0097150","count":3},{"id":"GO:0048366","count":3},{"id":"GO:0050775","count":3}]},{"hash":"2290189030718132064","title":"Amino acid and cofactor biosynthesis","description":"The top GO terms cluster around biosynthetic processes for amino acids and related cofactors (biotin biosynthesis, protoporphyrinogen IX/heme-related biosynthesis, transsulfuration, and antibiotic biosynthesis), with some auxiliary terms like cell division and development also present. This suggests the proteins participate broadly in metabolic biosynthesis pathways, rather than a single tight function. Some terms are obsolete or tangential (e.g., morphine response, GABA catabolic process), but the overall signal points to metabolism of amino acids and cofactors.","confidence":"Medium","size":23,"edges":14,"triangles":1,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0019878","count":6},{"id":"GO:0009102","count":5},{"id":"GO:0043278","count":5},{"id":"GO:0009097","count":5},{"id":"GO:0006782","count":4}]},{"hash":"2024809387268625737","title":"Translation and Ribosome Biogenesis","description":"The top GO terms are centered on translation and ribosome biogenesis, indicating a cluster of proteins involved in protein synthesis machinery and the assembly of ribosomes. Additional cell-cycle related terms suggest a link to growth and proliferation, while protein homooligomerization aligns with assembly and complex formation in the translation machinery. Obsolete terms can be ignored for functional interpretation, reinforcing a cohesive theme around ribosome function and protein synthesis.","confidence":"High","size":23,"edges":19,"triangles":4,"max_degree":14,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0001300","count":4},{"id":"GO:1903833","count":4},{"id":"GO:0070584","count":4},{"id":"GO:0051301","count":3}]},{"hash":"398649376439538839","title":"Neuronal synapse signaling and sensory perception","description":"This cluster is enriched for terms related to synapse localization and zonula adherens assembly, retrograde nitric oxide signaling, and sensory perception (sound/light), plus regulation of signaling pathways (Wnt, GTPase). These together suggest a coherent theme of neuronal communication and sensory processing at synapses, despite a couple of outliers that may reflect broader protein roles.","confidence":"High","size":23,"edges":169,"triangles":590,"max_degree":21,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0071625","count":13},{"id":"GO:0070433","count":13},{"id":"GO:0035418","count":12},{"id":"GO:0030111","count":12},{"id":"GO:0050953","count":12}]},{"hash":"224735535011585062","title":"Neural and sensory organ development","description":"The top GO terms center on development of neural tissues and sensory organs (midbrain, inner ear, eye/camera-type eye, visual perception) along with cerebellar signaling, and include related regulatory processes (Wnt signaling, transcriptional regulation). This pattern suggests proteins involved in neural/sensory organ development rather than a single specific function.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030901","count":12},{"id":"GO:0000122","count":12},{"id":"GO:0048839","count":11},{"id":"GO:0007601","count":11},{"id":"GO:0043010","count":11}]},{"hash":"298657387833291973","title":"Multisystem Cell Fate Specification","description":"The terms point to differentiation and developmental processes across several tissues (bone, pancreas, heart neural crest, inner ear, oligodendrocytes), plus regulation of signaling pathways, suggesting a broad developmental differentiation program rather than a single molecular function.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045668","count":20},{"id":"GO:0060766","count":20},{"id":"GO:0042491","count":18},{"id":"GO:0007540","count":18},{"id":"GO:0072277","count":18}]},{"hash":"2277912139496452111","title":"Cytoskeletal regulation of microvilli and brush border","description":"The top GO terms cluster around cytoskeletal dynamics and apical surface organization: regulation of Rho signaling and stress fiber assembly, microvillus and brush border assembly, and integrin-mediated cell adhesion. While there are also terms relating to synaptic plasticity, equilibrioception, and photoreceptor differentiation, the strongest signal is coordinated cytoskeletal remodeling and microvillar/brush border assembly in epithelial contexts, supporting a cohesive label focused on cytoskeletal regulation of apical structures.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0051835","count":5},{"id":"GO:0030033","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0033628","count":4}]},{"hash":"1198823857142822460","title":"Mitotic Cell Cycle and Division","description":"The cluster shows strong enrichment for mitosis and cell cycle terms, including cell division, mitotic cell cycle, and exit from mitosis, indicating involvement in mitotic progression and cytokinesis. The presence of division septum assembly reinforces a division-focused theme, while protein heterooligomerization and maintenance of cell polarity suggest assembly and regulation of multi-protein complexes and cell architecture during division. A Hedgehog-related signaling term and embryonic cell shape regulation hint at broader developmental control intertwined with cell cycle. Overall, the core signal is mitotic division and cell cycle control.","confidence":"High","size":23,"edges":99,"triangles":204,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":14},{"id":"GO:0000278","count":14},{"id":"GO:0010458","count":13},{"id":"GO:0000917","count":13},{"id":"GO:0051291","count":13}]},{"hash":"1131788685574244823","title":"Unknown","description":"The cluster shows a mix of GO terms across development (heart and skeletal system development, imaginal disc morphogenesis), tissue maintenance, and general cellular processes (ER-Golgi transport, GTPase regulation, GPCR signaling) with no single, coherent function linking most terms. This suggests the proteins participate in diverse roles rather than a unified pathway.","confidence":"","size":23,"edges":23,"triangles":1,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0030277","count":3},{"id":"GO:0007286","count":3},{"id":"GO:0006888","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1745144791837536709","title":"RNA processing and translation regulation","description":"The cluster is enriched for GO terms related to mRNA splicing (spliceosome), mRNA export, regulation of mRNA polyadenylation, and translational control (initiation, reinitiation, and stress-responsive mRNA stability). This combination points to a cohesive set of proteins involved in post-transcriptional RNA maturation and regulation of translation.","confidence":"High","size":23,"edges":4,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":9},{"id":"GO:0001731","count":9},{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0045292","count":7}]},{"hash":"2072213672172625314","title":"Mitochondrial Transport and Membrane Dynamics","description":"Predominantly mitochondrial functions: ADP/ATP and ion transport, iron import, membrane fission, and regulation of membrane potential. These terms indicate a cluster of proteins involved in mitochondrial energy metabolism and membrane dynamics, with supporting signals from cellular stress responses. The name reflects the core mitochondrial transport and membrane-regulatory roles.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034198","count":18},{"id":"GO:0000002","count":18},{"id":"GO:0048250","count":17},{"id":"GO:0035435","count":17},{"id":"GO:0015866","count":17}]},{"hash":"1123709334671260008","title":"Neural Development and Sensory/Reward Signaling","description":"The dominant terms point to brain function and sensory processing, including visual perception/learning and responses to addictive substances (cocaine, morphine) with signaling regulation (ERK cascade, GTPase activity). A brain-unique system (brain renin\u2013angiotensin) reinforces the neural theme, though a couple of outliers (heart development, macrophage chemotaxis) exist. Overall, the cluster centers on neural development and sensory/reward signaling.","confidence":"High","size":23,"edges":234,"triangles":1407,"max_degree":22,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":18},{"id":"GO:0070374","count":18},{"id":"GO:0048148","count":18},{"id":"GO:0010759","count":18},{"id":"GO:0019233","count":18}]},{"hash":"1960379133739922127","title":"Dopaminergic Signaling and Drug Response","description":"This cluster is dominated by neural signaling terms: dopaminergic synaptic transmission, visual and sensory perception, and a behavioral response to cocaine, along with ERK signaling regulation. The xenobiotic and prostaglandin stimulus responses support a theme of drug- and stimulus-driven neural activity, with heart development appearing as a more incidental term.","confidence":"High","size":23,"edges":138,"triangles":275,"max_degree":19,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":20},{"id":"GO:0007507","count":19},{"id":"GO:0070374","count":19},{"id":"GO:0048148","count":19},{"id":"GO:0010759","count":19}]},{"hash":"32136427223824871","title":"Reproductive tissue development and cell cycle regulation","description":"The cluster is enriched for DNA-templated transcription and mitotic cell cycle transitions, with tissue-specific terms for mammary gland development and Leydig cell differentiation, suggesting coordinated transcription and proliferation in reproductive tissues.","confidence":"Medium","size":23,"edges":222,"triangles":1242,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":17},{"id":"GO:0033598","count":14},{"id":"GO:0010696","count":14},{"id":"GO:2000775","count":14},{"id":"GO:0000082","count":14}]},{"hash":"746456594383784776","title":"Cardiovascular GPCR-cAMP signaling and energy metabolism","description":"The strongest shared signal is GPCR-mediated activation of adenylate cyclase and cAMP signaling, reflected by GO:0010579 and GO:0007190, with positive regulation of blood pressure (GO:0045777). The accompanying GO:0022900 (electron transport chain) and GO:0002024 (diet induced thermogenesis) suggest coupling to energy metabolism, consistent with signaling activity in cardiovascular/respiratory tissues. While other terms exist (saliva secretion, eosinophil degranulation, lung development), the core theme is GPCR\u2013cAMP signaling linked to metabolic output in relevant tissues.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":19},{"id":"GO:0022900","count":19},{"id":"GO:0010579","count":19},{"id":"GO:0007190","count":18},{"id":"GO:0019233","count":17}]},{"hash":"1137327778362644343","title":"Musculoskeletal and Cardiac Development","description":"This cluster's GO terms center on cartilage and bone formation (trachea/bronchus cartilage development, osteoblast differentiation, roof of the mouth development), skeletal muscle differentiation, and cardiac ventricle formation, with related transcriptional activity and TGF-\u03b2 signaling. Together they reflect a coherent mesoderm-derived program coordinating musculoskeletal and heart development.","confidence":"High","size":23,"edges":145,"triangles":441,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":14},{"id":"GO:0060534","count":14},{"id":"GO:0061145","count":13},{"id":"GO:0071864","count":13},{"id":"GO:0060532","count":13}]},{"hash":"1791667308584778823","title":"Neural development and synapse formation","description":"The top terms are strongly biased toward nervous system development and connectivity, including positive regulation of synapse assembly, corticospinal neuron axon guidance, and layer formation in the cerebral cortex, with supporting signals like sensory perception of pain. A few terms (keratinocyte differentiation, bone mineralization, drug responses) appear as outliers, suggesting some annotation noise but not overriding the main neural-development theme. Confidence: Medium.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":7},{"id":"GO:0042220","count":6},{"id":"GO:0030216","count":4},{"id":"GO:0032495","count":4},{"id":"GO:0007275","count":4}]},{"hash":"1975494459665063047","title":"Diverse cell fate and apoptosis across tissues","description":"Top GO terms span hepatocyte apoptosis, myeloid and fat cell differentiation, epithelial polarity, endothelial differentiation, cell migration, NOD2 signaling, venous differentiation, cardiac action potential modulation, and pain/sensory detection. The common thread is broad cell fate decisions and programmed cell death across multiple tissues, rather than a single, cohesive pathway. This supports a general theme of differentiation and apoptotic regulation in diverse biological contexts.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0097284","count":7},{"id":"GO:0090162","count":7},{"id":"GO:0016477","count":7},{"id":"GO:0010745","count":7},{"id":"GO:0033028","count":7}]},{"hash":"633593081745288145","title":"Actin-driven cell migration and adhesion","description":"This cluster is dominated by GO terms related to actin cytoskeleton dynamics and cell movement, including activation of GTPase activity, filopodium and lamellipodium assembly, and substrate adhesion-dependent cell spreading. These point to coordinated cytoskeletal remodeling and adhesion processes essential for cell migration; additional terms about extracellular matrix (hyaluronan metabolism) and morphogenesis support involvement in tissue remodeling. Immune activation terms may reflect downstream effects requiring cytoskeletal changes, but the core theme is cytoskeletal-driven motility and adhesion.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0090630","count":17},{"id":"GO:0046847","count":17},{"id":"GO:1900026","count":17},{"id":"GO:0060313","count":17},{"id":"GO:0043314","count":17}]},{"hash":"1424788712185206661","title":"Rho GTPase signaling and actin remodeling","description":"The top GO terms cluster around regulation and signaling of Rho family GTPases, which coordinate actin cytoskeleton dynamics (including microspike assembly) and cell surface localization, pointing to roles in cell migration and cytoskeletal remodeling. Phosphatidylinositol-mediated signaling also aligns with membrane-associated signaling that feeds into cytoskeletal changes. While angiogenesis and neuroblast proliferation terms appear, the dominant theme is Rho GTPase-mediated cytoskeletal regulation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0043524","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0034394","count":3}]},{"hash":"107099177860053947","title":"Craniofacial and mesodermal developmental transcription","description":"The cluster\u2019s top GO terms converge on developmental processes\u2014palate (roof of mouth) development, hair follicle morphogenesis, mesoderm and left-right patterning\u2014largely tied together by transcriptional regulation (DNA-templated transcription and negative regulation of transcription by RNA Pol II). This suggests a coordinated program of gene expression driving craniofacial and mesodermal development, with supporting roles in RNA processing and export.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":22},{"id":"GO:0006351","count":21},{"id":"GO:0000122","count":21},{"id":"GO:0031069","count":21},{"id":"GO:0035270","count":21}]},{"hash":"230829400096463087","title":"Cell Adhesion and Inflammatory Signaling","description":"Based on the top terms, the cluster centers on cell adhesion (cell-matrix adhesion and cell adhesion) and innate immune/inflammatory signaling (NF-kappaB pathway and TLR signaling regulation), with supporting terms touching tissue regeneration and vascular remodeling. This suggests proteins co-regulating adhesion processes with immune-responsive signaling and tissue remodeling, justifying a label that reflects both adhesion and inflammatory signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001954","count":3},{"id":"GO:0007568","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0007155","count":2},{"id":"GO:1990384","count":2}]},{"hash":"154952582217446716","title":"Ubiquitin-Dependent Apoptosis and TNF Signaling","description":"The cluster is dominated by GO terms related to ubiquitination (ubiquitin-dependent protein catabolic process, protein ubiquitination) and regulation of apoptotic processes, including TNF-mediated signaling. This suggests a set of proteins that link ubiquitin tagging to control of apoptosis and TNF signaling, potentially affecting downstream NF-\u03baB\u2013related pathways.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0043066","count":7},{"id":"GO:0032088","count":7},{"id":"GO:0016567","count":6},{"id":"GO:0070512","count":6}]},{"hash":"1016837721307970842","title":"TGF-beta signaling in development and immunity","description":"This cluster centers on responses to TGF-beta and related developmental processes (heart and mammary gland morphogenesis) alongside immune signaling pathways (innate response, B cell receptor, Fc-epsilon receptor, IL-2 production), indicating a link between developmental regulation and immune signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071560","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0043552","count":4},{"id":"GO:2000251","count":4},{"id":"GO:0060444","count":4}]},{"hash":"125764500359146675","title":"Actin-driven dendrite and lamellipodium morphogenesis","description":"This cluster centers on actin cytoskeleton remodeling involved in dendrite and spine morphogenesis and lamellipodium formation. The top GO terms include actin filament organization, lamellipodium assembly, dendrite morphogenesis, dendritic spine morphogenesis, lamellipodium morphogenesis, Rac signal transduction, and actin polymerization/capping. Together they point to proteins regulating actin dynamics to shape neuronal processes and cell protrusions.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048813","count":2},{"id":"GO:0060997","count":2},{"id":"GO:0072673","count":2},{"id":"GO:0010592","count":2},{"id":"GO:1900029","count":2}]},{"hash":"303715755767582624","title":"Endosome trafficking and GTPase signaling in immunity","description":"The top GO terms indicate a theme of endosome organization and transport, coupled with regulation by small GTPases (Rho, Rap, Ral). The inclusion of innate immune response and endothelial barrier establishment suggests this cluster reflects vesicle trafficking\u2013dependent signaling that modulates immune and vascular functions. The combination of trafficking and signaling terms points to a cohesive functional module rather than disparate processes.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007032","count":3},{"id":"GO:0045087","count":2},{"id":"GO:0048009","count":2},{"id":"GO:0070493","count":2},{"id":"GO:0035023","count":2}]},{"hash":"864709072511492165","title":"Neural development and axon guidance","description":"Based on the prevalent GO terms, the proteins cluster around nervous system development, axon guidance and synapse assembly (including axonal fasciculation, branchiomotor neuron guidance, trigeminal nerve organization, neural crest migration, and myelination). Innate immune response appears but is less central. Overall, this cluster reflects a neural wiring/development module focused on guidance and synapse formation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0014068","count":11},{"id":"GO:0042552","count":10},{"id":"GO:0051965","count":10},{"id":"GO:0007413","count":9},{"id":"GO:0045087","count":9}]},{"hash":"40961253053586500","title":"Neuronal synaptic signaling and plasticity","description":"The top GO terms cluster around synaptic organization and plasticity, including NMDA/AMPA receptor clustering and long-term potentiation, plus GTPase-regulated cytoskeletal dynamics and neuronal signaling pathways (e.g., insulin receptor signaling in neurons). Some terms (hepatocyte apoptotic process, histone acetylation) seem less connected and may be incidental. Overall, the cluster centers on neuronal synaptic signaling and plasticity.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0097284","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0014012","count":4},{"id":"GO:0097114","count":4}]},{"hash":"1068285637640622328","title":"Mesodermal development and cytoskeleton signaling","description":"The cluster\u2019s top GO terms point to mesodermal development (multicellular organism development, skeletal system development, lateral mesodermal cell fate specification) and cytoskeleton regulation (actin cytoskeleton organization by cell-cell adhesion), with supporting signaling pathways (VEGF-activated PDGFR signaling, PI3K activity). Some immune regulation terms are present but the dominant theme ties to mesodermal morphogenesis and cytoskeletal dynamics, suggesting roles in tissue development and structural organization.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002859","count":10},{"id":"GO:0043318","count":10},{"id":"GO:0090138","count":10},{"id":"GO:2000830","count":9},{"id":"GO:0043552","count":9}]},{"hash":"1704888354328609735","title":"Mitotic Cell Cycle and Cytokinesis Regulation","description":"This cluster is dominated by GO terms related to mitosis and cytokinesis (cell cycle, cell division, mitotic sister chromatid cohesion, cleavage furrow formation, septum digestion after cytokinesis) and regulation of GTPase activity, suggesting proteins that coordinate mitotic progression and cytokinesis. Some terms like brain development and mRNA processing hint at multifunctional roles, but the strongest shared theme is cell division regulation. There are no edges to provide network context, so the label relies on term coherence.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0051260","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0007064","count":2}]},{"hash":"534692640717252625","title":"Ribosome biogenesis and mitochondrial translation","description":"The cluster is strongly enriched for translation-related processes, including DNA-templated transcription, general translation, mitochondrial translation, and ribosomal large subunit assembly, with some negative regulation of translation. This points to a set of proteins involved in ribosome assembly and protein synthesis, particularly within mitochondria, with ancillary ties to iron-sulfur cluster assembly and related regulatory processes.","confidence":"High","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0006412","count":5},{"id":"GO:0032543","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0046677","count":2}]},{"hash":"970466335471841562","title":"ERAD-Linked Proteostasis and Autophagy","description":"This cluster is enriched for ubiquitin-dependent ERAD, deubiquitination, and unfolded protein maintenance, along with autophagy-related processes (aggrephagy, autophagosome maturation), indicating a proteostasis/quality-control module spanning ER quality control and autophagy, with some trafficking-related regulation.","confidence":"High","size":22,"edges":226,"triangles":1443,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":9},{"id":"GO:0016579","count":9},{"id":"GO:1904378","count":8},{"id":"GO:1900186","count":7},{"id":"GO:0006517","count":7}]},{"hash":"976973898985943884","title":"Meiotic DNA Repair and Recombination","description":"This cluster is enriched for GO terms related to DNA replication, recombination, and repair, especially in meiosis and oocyte development (e.g., oocyte karyosome formation and meiotic recombination repair). The presence of DNA integration and repair processes suggests roles in chromosomal maintenance and recombination during meiosis. Overall, these proteins likely function together in meiotic genome maintenance and recombination.","confidence":"High","size":22,"edges":138,"triangles":422,"max_degree":19,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0030717","count":3},{"id":"GO:1990918","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0006310","count":3}]},{"hash":"2100468729939317396","title":"Lymphocyte signaling and cytoskeletal regulation","description":"The cluster is enriched for immune-related signaling terms (NK T cell differentiation, B cell receptor signaling, IL-7 response, TGF-\u03b2 stimulus) and for cytoskeletal dynamics (Arp2/3-mediated actin nucleation; Rac/Rho and GTPase activity regulation), suggesting a shared function in lymphocyte activation coupled with cytoskeletal remodeling; a single outlier term (uterus development) may reflect broader pleiotropy.","confidence":"Medium","size":22,"edges":39,"triangles":0,"max_degree":20,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071560","count":8},{"id":"GO:0001865","count":7},{"id":"GO:0098761","count":7},{"id":"GO:0043552","count":7},{"id":"GO:0060065","count":7}]},{"hash":"1494539645240687029","title":"Neural development and signaling proteins","description":"The top GO terms show a clear emphasis on neural lineage development (hippocampus development, Schwann cell development) and neuronal signaling processes (excitatory postsynaptic potential), with key signaling cascades (ERK1/ERK2, PI3K) represented. While DNA replication and repair terms are present, the predominant theme centers on neural development and synaptic signaling, suggesting proteins involved in neural differentiation and communication. ","confidence":"Medium","size":22,"edges":17,"triangles":5,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":21},{"id":"GO:0043552","count":19},{"id":"GO:0060079","count":19},{"id":"GO:0050852","count":19},{"id":"GO:0006281","count":19}]},{"hash":"2083637317095193897","title":"Amino-sugar and carbohydrate metabolism","description":"The top GO terms cluster around sugar metabolism: N-acetylglucosamine and glucosamine catabolism and biosynthesis (UDP-GlcNAc), pentose-phosphate shunt (oxidative branch), and related carbohydrate processes, with an additional link to epoxygenase P450 metabolism. This suggests a cohesive theme of carbohydrate fate and nucleotide-sugar biosynthesis across the proteins.","confidence":"High","size":22,"edges":6,"triangles":0,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0005975","count":4},{"id":"GO:0006098","count":3},{"id":"GO:0006046","count":3},{"id":"GO:0009051","count":3},{"id":"GO:0006048","count":3}]},{"hash":"1779116685025535135","title":"Transmembrane Transporters","description":"This cluster is dominated by GO terms for transmembrane transport across membranes, covering potassium, nitrate/nitrite, phosphate, galactose, vitamins, and xenobiotics, plus vesicular neurotransmitter loading. The shared function across these terms suggests a group of transporter proteins with diverse substrates, or a broader transporter family. The relatively sparse network edges do not contradict a cohesive transport-related theme given the GO pattern.","confidence":"High","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":6},{"id":"GO:0015706","count":5},{"id":"GO:1900754","count":5},{"id":"GO:0035435","count":5},{"id":"GO:0042128","count":5}]},{"hash":"1752727266948040843","title":"Proteostasis Under Heat Stress","description":"The cluster shows strong enrichment for unfolded protein response, heat stress response, misfolded protein transport, and ubiquitin-proteasome\u2013mediated quality control, all pointing to a cohesive network that maintains protein folding and degrades damaged proteins under heat stress. Some terms like translation frameshifting and mitochondrial targeting are present but do not override the central proteostasis theme.","confidence":"High","size":22,"edges":230,"triangles":1520,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006469","count":10},{"id":"GO:0032781","count":10},{"id":"GO:1900035","count":10},{"id":"GO:0009408","count":10},{"id":"GO:0006452","count":10}]},{"hash":"250713226331157002","title":"Multi-tissue Developmental Differentiation","description":"These proteins are linked to differentiation and development across multiple tissues\u2014neural crest\u2013derived structures (e.g., cardiac outflow tract), glial lineages (astrocyte, oligodendrocyte development), inner ear sensory cells, kidney glomerular formation, pancreatic endocrine fates, and osteoclast maturation, with additional lineage- and hormone-related differentiation terms. The broad spread of developmental terms suggests a general developmental/differentiation theme rather than a single specific function.","confidence":"Medium","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2001038","count":21},{"id":"GO:0048712","count":21},{"id":"GO:0042491","count":20},{"id":"GO:0007540","count":20},{"id":"GO:0072277","count":20}]},{"hash":"14361770355057165","title":"Sarcomere function and sensory perception","description":"The cluster is dominated by terms for cardiac muscle contraction and sarcomere organization, pointing to muscle contractile machinery, while also showing sensory terms for vision and olfaction, suggesting a broader sensorimotor role that spans both muscle function and sensory signaling.","confidence":"Medium","size":22,"edges":40,"triangles":23,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060048","count":20},{"id":"GO:0007601","count":18},{"id":"GO:0007602","count":18},{"id":"GO:0003065","count":17},{"id":"GO:1904753","count":17}]},{"hash":"17917810067973904","title":"Vesicle trafficking and organelle biogenesis","description":"The top GO terms emphasize membrane-associated and vesicle-related processes, including proton transmembrane transport, CVT vesicle assembly, and vacuole inheritance, suggesting a core theme of intracellular trafficking and organelle formation. Other terms point to broader cellular organization or development (nuclear import, chromatin remodeling, desmosome assembly, vasculogenesis, renal vesicle formation), which indicates heterogeneity across contexts, but the vesicle/organellar emphasis provides the most coherent link among the cluster\u2019s functions.","confidence":"Medium","size":22,"edges":3,"triangles":0,"max_degree":1,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0015991","count":13},{"id":"GO:0006607","count":12},{"id":"GO:0043547","count":12},{"id":"GO:0000011","count":11},{"id":"GO:0002159","count":11}]},{"hash":"1066247075407427711","title":"ER stress and innate antiviral response","description":"The terms cluster around ER stress\u2013driven pathways: unfolded protein response, endoplasmic reticulum\u2013associated protein folding and chaperone activity, and translation initiation regulation in response to ER stress, coupled with redox/homeostasis and defense against viruses. The inclusion of innate immune response and related inflammatory signals suggests these proteins participate in coordinating ER quality control with antiviral defense and oxidative stress management.","confidence":"High","size":22,"edges":27,"triangles":6,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0006986","count":4},{"id":"GO:0070389","count":4},{"id":"GO:0036494","count":4},{"id":"GO:0055114","count":4}]},{"hash":"1817838421537879674","title":"Caveolin-mediated endocytosis and membrane signaling","description":"The top terms include caveolin-mediated endocytosis and several membrane- and signaling-related processes (lipid biosynthesis, cell proliferation signals, neuronal development, cytokine response, and centrosome cycle), suggesting a membrane-anchored signaling/trafficking cluster with broader roles in growth and development. ","confidence":"Medium","size":22,"edges":80,"triangles":124,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0072584","count":21},{"id":"GO:0033598","count":21},{"id":"GO:1990804","count":21},{"id":"GO:0007098","count":21},{"id":"GO:0043506","count":21}]},{"hash":"1282212499973252753","title":"ER protein targeting and unfolded protein response","description":"The cluster is dominated by GO terms related to SRP-dependent cotranslational protein targeting to the ER membrane and membrane-associated protein targeting (both cotranslational and post-translational), along with cellular response to unfolded protein and post-translational protein targeting. This pattern points to a coherent theme of membrane targeting of nascent proteins and ER-associated protein folding/quality control, i.e., ER stress response. Some terms about iron-sulfur assembly and other stress-related processes appear ancillary but do not override the main theme.","confidence":"High","size":22,"edges":21,"triangles":9,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006616","count":5},{"id":"GO:0070389","count":3},{"id":"GO:1903751","count":3},{"id":"GO:0070880","count":3},{"id":"GO:0034620","count":3}]},{"hash":"1962146629472247847","title":"DNA Damage Response and Repair","description":"Top terms cluster around nucleotide-excision repair, base-excision repair, DNA replication, and gamma radiation response, indicating genome integrity maintenance and error-free bypass; secondary terms like inflammatory response and development appear peripheral.","confidence":"High","size":22,"edges":14,"triangles":0,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006297","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0071480","count":4},{"id":"GO:0070987","count":3},{"id":"GO:0048536","count":3}]},{"hash":"1279964107661006186","title":"Ribosome Biogenesis and Nuclear Transport","description":"This cluster is dominated by processes involved in ribosome assembly and the nucleocytoplasmic trafficking of ribosomal components and mRNA, as shown by terms such as ribosome biogenesis, translation preinitiation complex formation, translation reinitiation, ribosomal protein import into the nucleus, NLS-bearing protein import, and mRNA export. The presence of nuclear pore complex assembly also supports a coherent theme of nuclear\u2013cytoplasmic transport linked to ribosome production and initiation of translation.","confidence":"High","size":22,"edges":210,"triangles":1181,"max_degree":21,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0006406","count":3}]},{"hash":"184274091071949421","title":"Chromatin remodeling and p53-mediated DNA damage response","description":"This cluster is anchored by GO terms for chromatin remodeling and nucleosome disassembly, and by GO terms describing regulation of DNA damage response via p53. Together these point to a shared role in chromatin dynamics governing DNA damage signaling and transcriptional responses, with the other terms reflecting broader connections to cell proliferation and differentiation. Confidence is moderate because a few terms relate to unrelated developmental processes, but the core signal centers on chromatin remodeling tied to p53-mediated DNA damage pathways.","confidence":"Medium","size":22,"edges":28,"triangles":3,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:1902166","count":2},{"id":"GO:2000179","count":2},{"id":"GO:0043044","count":2},{"id":"GO:0043518","count":2},{"id":"GO:0006337","count":2}]},{"hash":"564499025899249839","title":"Neural Sensory Processing and Thermoregulation","description":"The cluster centers on neural signaling and sensory-related processes: pain perception, thermogenesis, temperature-responsive cellular signaling, membrane potential regulation, and pathways like ERK cascade, plus behavioral responses to cocaine. Vision and heart development are present but less representative, suggesting a primary theme around neural sensory processing and thermoregulatory signaling with some pleiotropic terms.","confidence":"Medium","size":22,"edges":29,"triangles":3,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":17},{"id":"GO:0002024","count":16},{"id":"GO:0071502","count":16},{"id":"GO:0042391","count":15},{"id":"GO:0007601","count":14}]},{"hash":"430270667013641116","title":"Cell cycle and DNA replication regulators","description":"This cluster is dominated by GO terms for centrosome cycle, DNA replication, mitotic cell cycle, and regulation of nuclear DNA replication, pointing to proteins involved in cell cycle progression and replication control. While some terms (e.g., caveolin-mediated endocytosis and mammary gland epithelial cell proliferation) are less central, the strongest shared theme is coordination of centrosome dynamics with DNA replication and mitosis.","confidence":"High","size":22,"edges":113,"triangles":249,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007098","count":21},{"id":"GO:0006260","count":21},{"id":"GO:0048701","count":21},{"id":"GO:0007601","count":21},{"id":"GO:0000278","count":21}]},{"hash":"468576870890211833","title":"Neural Development and Wnt/ERK Signaling","description":"This cluster centers on developmental signaling affecting nervous system formation (nervous system development; substantia nigra development) and morphogenesis, with notable regulation of ERK1/ERK2 cascade, GTPase activity, and canonical Wnt signaling. It also touches epithelial and hair follicle morphogenesis, indicating cross-tissue development roles, and includes a neuroprotective angle (negative regulation of neuron apoptotic process). The combined GO terms point to a cohesive theme of signaling-driven development in neural and epithelial contexts.","confidence":"High","size":22,"edges":8,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":11},{"id":"GO:0043547","count":11},{"id":"GO:0043524","count":10},{"id":"GO:0021762","count":10},{"id":"GO:0031532","count":10}]},{"hash":"1929536673623352108","title":"Actin-driven protrusions and endocytosis","description":"The top terms consistently point to actin cytoskeleton remodeling events (filopodium, podosome, and ruffle assembly, plus general actin reorganization) and membrane trafficking processes (endocytosis and engulfment of apoptotic cells), with ubiquitination often regulating these steps. This suggests a cohesive cluster centered on actin-based membrane remodeling and phagocytic/endocytic functions.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":4},{"id":"GO:0071803","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0031532","count":4},{"id":"GO:0016567","count":4}]},{"hash":"1007190398924958799","title":"Macrophage activation and actin remodeling","description":"Most representative terms point to actin remodeling (filopodium assembly, GTPase activity) and immune responses (macrophage differentiation, inflammatory response). TORC1 signaling and post-transcriptional RNA regulation appear as metabolic and translational control aspects tied to activation, suggesting a broader immune-activation program with cytoskeletal dynamics. Therefore, the cluster seems to reflect macrophage activation featuring actin remodeling and inflammation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":4},{"id":"GO:0043547","count":3},{"id":"GO:1900363","count":3},{"id":"GO:1903679","count":3},{"id":"GO:0043488","count":3}]},{"hash":"1938558614912633419","title":"Osteogenesis and ECM adhesion","description":"This cluster is dominated by bone formation signals such as bone trabecula formation and positive regulation of osteoblast differentiation, plus strong representation of cell-matrix and cell-cell adhesion and hyaluronan biosynthesis, all pointing to osteogenesis and extracellular matrix remodeling. Inflammatory response may accompany remodeling, reinforcing the bone-development theme, while a few obsolete GO terms don\u2019t change the core signal. ","confidence":"High","size":22,"edges":62,"triangles":68,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060346","count":16},{"id":"GO:0007275","count":16},{"id":"GO:1900127","count":15},{"id":"GO:0007160","count":15},{"id":"GO:0007157","count":15}]},{"hash":"102714196079440160","title":"Developmental ECM Remodeling","description":"The top GO terms point to developmental processes (midbrain development, cartilage development, fertilization) along with extracellular matrix remodeling (collagen catabolic process) and immune/coagulation activities (complement activation, blood coagulation). This mix centers on tissue development and remodeling with ECM turnover, so Developmental ECM Remodeling captures the dominant theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030901","count":8},{"id":"GO:0000122","count":6},{"id":"GO:0051216","count":5},{"id":"GO:0045944","count":5},{"id":"GO:0001867","count":5}]},{"hash":"1600179733798776620","title":"Craniofacial development and patterning","description":"The dominant GO terms point to developmental processes in craniofacial regions, including roof of the mouth/palate development, hair follicle morphogenesis, mesoderm development, and left-right axis formation, indicating a cohesive role in craniofacial patterning and body-axis development. Some terms reflect general cellular processes, but the strongest signal is developmental regulation related to facial structures and patterning.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":16},{"id":"GO:0031069","count":13},{"id":"GO:0046022","count":13},{"id":"GO:0007576","count":13},{"id":"GO:0035270","count":13}]},{"hash":"207681920239802268","title":"Ubiquitin-Dependent Protein Degradation and Cell Cycle Regulation","description":"The cluster is strongly enriched for ubiquitination-related processes (ubiquitin-dependent proteolysis, protein ubiquitination, protein autoubiquitination) and includes regulators of apoptosis, transcription, and cell cycle. This points to a set of proteins involved in ubiquitin-mediated protein turnover that modulates cell fate and growth, hence a cohesive theme around protein degradation and cell cycle control.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0043066","count":10},{"id":"GO:0016567","count":9},{"id":"GO:0000122","count":9},{"id":"GO:0051865","count":8}]},{"hash":"1918359947243159215","title":"Embryonic Neural and Tissue Morphogenesis","description":"The top GO terms indicate widespread developmental activity across nervous system components (brain/mmidbrain/nervous system development) and diverse tissues (lens, cartilage, EMT-related heart formation), suggesting a cluster of proteins involved in embryonic tissue morphogenesis and neural differentiation. Some terms like spliceosome-mediated splicing and Gram-positive defense appear as general or peripheral processes, but do not override the main developmental theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0030901","count":4},{"id":"GO:0007399","count":3},{"id":"GO:0070306","count":3}]},{"hash":"431380979552721701","title":"Developmental transcriptional regulators","description":"The cluster shows strong enrichment for GO terms related to transcription regulation by RNA polymerase II (both positive and negative) alongside various embryonic development processes (placental, left-right patterning, midbrain, facial/moments of morphogenesis, EMT), suggesting these proteins commonly function as transcriptional regulators driving developmental programs.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0060707","count":4},{"id":"GO:0060972","count":4},{"id":"GO:0003323","count":4},{"id":"GO:0045944","count":4}]},{"hash":"302116765254265587","title":"Vesicle trafficking and Golgi-ER transport","description":"The top GO terms center on intracellular transport and membrane remodeling, including Golgi-to-ER retrograde transport, Golgi organization, and the Cvt pathway, plus plasma membrane tubulation and regulation of GTPase activity. Together these point to a cohesive role in vesicle trafficking and membrane dynamics, with GTPases likely coordinating these steps. Some terms (bone development, meiosis) are peripheral, but the dominant theme is vesicle trafficking/secretory system function.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":4},{"id":"GO:0032258","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0097320","count":3}]},{"hash":"484944594263932855","title":"Developmental transcriptional regulation","description":"This cluster is driven by GO terms for DNA-templated transcription and negative regulation of transcription, coupled with several developmental processes such as endocardial cushion formation, pancreatic cell development, trophoblast differentiation, and cartilage morphogenesis. While there are some metabolism-related terms present, the transcription and development signals are the strongest unifying theme, suggesting a group of proteins involved in regulating gene expression during development.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0009102","count":4}]},{"hash":"543635274671200948","title":"Cytoskeletal dynamics in development and signaling","description":"Based on the GO terms, the cluster centers on cytoskeletal regulation and signaling: regulation of Rho and GTPase activity, sarcomere organization, and skeletal development point to actin-metwork remodeling and muscle structure; axonogenesis and neuron projection guidance indicate neural development reliant on cytoskeletal changes; multicellular organism development and apoptotic/inflammatory terms suggest broader developmental and cellular signaling roles. Together, these terms imply a cohesive theme of cytoskeletal dynamics guiding development in muscle and nerve, with some ancillary immune-related processes. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0045214","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1791338750908499447","title":"Ubiquitin-dependent regulation of signaling and development","description":"The top GO terms cluster around ubiquitination processes (ubiquitin-dependent protein catabolic process, K33-linked ubiquitination, negative regulation of protein ubiquitination) and circadian rhythm regulation, with additional terms relating to development and signaling in immune, muscle, and renal contexts. This suggests a core theme of ubiquitin-mediated control influencing diverse signaling and developmental pathways across tissues, rather than a single, narrow function.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:0042752","count":16},{"id":"GO:0048741","count":10},{"id":"GO:0002467","count":10},{"id":"GO:1990390","count":10}]},{"hash":"2066421945686232017","title":"Organ Development and Immune Signaling","description":"The top GO terms span organogenesis (heart, retina, lung connective tissue) and vascular endpoints (endothelial barrier) along with immune-related activities (eosinophil degranulation, neutrophil killing of Gram-negative bacteria, LPS response, dendritic cell chemotaxis). This pattern suggests a cluster of genes involved in tissue development coupled with immune signaling, rather than a single narrow pathway. Confidence: Medium","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":18},{"id":"GO:0060427","count":18},{"id":"GO:0070963","count":18},{"id":"GO:0051482","count":18},{"id":"GO:0060041","count":18}]},{"hash":"1708620681337347077","title":"Innate Immune Activation and Chemotaxis","description":"The GO terms strongly point to innate immune functions (eosinophil degranulation, neutrophil killing of Gram-negative bacteria, dendritic cell chemotaxis, and lipopolysaccharide response), suggesting proteins involved in leukocyte activation and inflammatory signaling. Additional terms toward tissue development and GPCR signaling may reflect broader annotations, but the core theme is innate immune response.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":22},{"id":"GO:0060427","count":22},{"id":"GO:0070963","count":22},{"id":"GO:0051482","count":22},{"id":"GO:0060041","count":22}]},{"hash":"1723499284520332364","title":"RNA processing and translational regulation","description":"This cluster is dominated by GO terms tied to RNA metabolism and translation control, including mRNA splicing via the spliceosome, mRNA export, 7-methylguanosine capping, and regulation of translational initiation, with additional links to ncRNA-mediated silencing and viral translation processes, pointing to coordinated post-transcriptional processing and regulation of gene expression.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006446","count":5},{"id":"GO:0048026","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0045292","count":4}]},{"hash":"882967612884226072","title":"Immune Activation and Tissue Development","description":"Top GO terms show immune-related activities (positive regulation of eosinophil degranulation; dendritic cell chemotaxis; response to lipopolysaccharide; neutrophil-mediated killing) alongside tissue/organ development terms (lung connective tissue development; retina development; heart development; endothelial barrier establishment). This mix suggests a cluster of proteins involved in immune signaling that also participate in developmental processes across multiple tissues. The absence of edges indicates a broad, annotation-driven grouping rather than a single cohesive pathway, but the recurring themes center on immune activation and tissue formation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":21},{"id":"GO:0060427","count":21},{"id":"GO:0070963","count":21},{"id":"GO:0051482","count":21},{"id":"GO:0060041","count":21}]},{"hash":"222657042930457376","title":"Unknown","description":"The top GO terms span diverse processes\u2014from auditory sensation and neuronal synaptic plasticity to tight junctions, eisosome assembly, myelination, and transcytosis\u2014covering neural, immune, and membrane trafficking functions with no clear single theme. Because of this broad and disjointed functional mix, there isn\u2019t a cohesive cluster function to name beyond Unknown.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0070830","count":2},{"id":"GO:0090038","count":2},{"id":"GO:0050861","count":2},{"id":"GO:0034115","count":2}]},{"hash":"645025687043759863","title":"Coagulation and vascular regulation","description":"The top terms cluster around hemostasis and vascular control: blood coagulation, platelet activation, positive regulation of vasoconstriction, and uterine smooth muscle contraction, suggesting a core theme of coagulation and vascular tone regulation. Additional terms on renal sodium excretion, chloride transport, neuropeptide signaling, and eosinophil degranulation point to broader endocrine and immune signaling contexts that can interface with vascular and fluid balance. Overall, the cluster appears to reflect coordinated regulation of coagulation and vascular function.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":9},{"id":"GO:0030321","count":8},{"id":"GO:0007625","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0030168","count":6}]},{"hash":"1028269620421180192","title":"Actin Cytoskeleton Remodeling in Innate Immunity","description":"The top GO terms cluster around innate immune response and actin cytoskeleton dynamics (microspike and podosome assembly, integrin signaling, GTPase activation), suggesting proteins that coordinate cell adhesion and movement during immune signaling. Development-related terms (spermatid development, wing hair organization) also reflect actin-driven morphogenesis, supporting a unifying theme of cytoskeleton remodeling in immunity and development.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0007286","count":2},{"id":"GO:0030035","count":2},{"id":"GO:0032956","count":2},{"id":"GO:0035317","count":2}]},{"hash":"1328305033071311932","title":"Neural Development and Myelination","description":"The top GO terms cluster around nervous system formation and maturation\u2014otolith morphogenesis, nervous system development, axonal fasciculation, synapse assembly, and myelination\u2014indicating proteins involved in neural development and neural connectivity; some terms are peripheral (bone development, PI3K signaling), but the dominant theme is neural development.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032474","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0051965","count":4},{"id":"GO:0042552","count":4},{"id":"GO:0007413","count":4}]},{"hash":"2276130319440012074","title":"DNA replication and genome maintenance","description":"The dominant terms in this cluster are centered on DNA replication and genome maintenance (DNA replication, DNA-templated replication, replication initiation, primer synthesis, DNA repair, and telomere maintenance via recombination). This strongly suggests the proteins share roles in replicative and repair processes. A few outlier terms (actin crosslink formation, regulation of Notch signaling, NMDA receptor activity, extracellular matrix disassembly) may reflect multifunctional proteins or annotation noise rather than core cluster function.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0051764","count":2},{"id":"GO:0006261","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0045746","count":2}]},{"hash":"1955417341962997885","title":"Melanosome biogenesis and vesicle trafficking","description":"This cluster's top GO terms point to pigment-related organelle formation and secretory pathway transport (melanosome assembly, COPII vesicle coating, intra-Golgi vesicle transport) with supporting pigment biosynthesis terms (ommochrome, quinolinate-related). A few terms are unrelated or obsolete, suggesting annotation noise, but the strongest signal ties pigment organelle biogenesis to vesicular trafficking.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048147","count":2},{"id":"GO:0019442","count":1},{"id":"GO:0019805","count":1},{"id":"GO:0019441","count":1},{"id":"GO:0055114","count":1}]},{"hash":"347729196185611646","title":"Embryonic morphogenesis and tissue development","description":"The top GO terms cluster around embryonic development and diverse morphogenetic processes across multiple tissues (cartilage, left/right patterning, hair follicle, placenta, mesoderm, EMT). This points to a broad developmental program rather than a single tissue, so a concise label like embryonic morphogenesis and tissue development fits well.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":21},{"id":"GO:0060972","count":21},{"id":"GO:0060806","count":21},{"id":"GO:0031069","count":21},{"id":"GO:0060021","count":21}]},{"hash":"1308537535553218430","title":"Metabolism and gene expression","description":"The cluster includes metabolic processes (L-glutamine and L-phenylalanine metabolism, TCA cycle, phenylacetate catabolism) along with core gene-expression activities (DNA-templated transcription, translation) and DNA repair, plus nutrient-response signals. This combination suggests a central cellular program coordinating metabolism with transcription/translation and genome maintenance in response to nutrients.","confidence":"Medium","size":21,"edges":103,"triangles":339,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006814","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0006541","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0055114","count":2}]},{"hash":"1664664111172152303","title":"Ribosome biogenesis and translation machinery","description":"The top terms highlight ribosome-related processes: translation, ribosome assembly, and rRNA processing, indicating a cluster of proteins involved in ribosome biogenesis and protein synthesis; additional terms suggest general cellular energy maintenance, while a few outliers (defense and DNA repair) are unlikely to define the primary function.","confidence":"Medium","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:1902600","count":2},{"id":"GO:0009060","count":2},{"id":"GO:0046677","count":1},{"id":"GO:0000448","count":1}]},{"hash":"720359926543737838","title":"Mitochondrial and Cytoplasmic Translation & rRNA Maturation","description":"This cluster is dominated by GO terms for translation (cytoplasmic and mitochondrial) and maturation of SSU rRNA, with a notable link to mitochondrial translation and electron transport. The strongest signal points to protein synthesis machinery in both cytosol and mitochondria, possibly tied to ribosome biogenesis/maintenance and mitochondrial metabolism, with ancillary transcription and apoptotic signals. Overall, the theme is coherent around translation and mitochondrial ribosome function.","confidence":"Medium","size":21,"edges":208,"triangles":1293,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":11},{"id":"GO:0002184","count":3},{"id":"GO:0032543","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0006351","count":1}]},{"hash":"1930007915775204938","title":"Neural development and synaptic trafficking","description":"The top GO terms converge on neural morphogenesis (auditory receptor morphogenesis, nerve branching), filopodium/leading-edge regulation, evoked neurotransmitter secretion, and endosomal/membrane trafficking, suggesting a cohesive cluster of proteins coordinating neurite outgrowth, synaptic vesicle dynamics, and ubiquitin-mediated regulation; a few terms (mitotic spindle orientation checkpoint) are less connected but do not dominate the set.","confidence":"Medium","size":21,"edges":84,"triangles":146,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016567","count":18},{"id":"GO:0002093","count":17},{"id":"GO:0031578","count":17},{"id":"GO:0061670","count":17},{"id":"GO:0051489","count":17}]},{"hash":"11886161648107110","title":"Unknown","description":"The top GO terms cover mitochondrial complex IV assembly, ion transport, septate junction assembly, NF-kappaB signaling regulation, photoreceptor signaling, synaptic vesicle clustering, interferon response, biotic stimulus response, and bone development/mineralization. This range spans metabolism, membrane transport, cell junctions, signaling, immunity, and skeletogenesis, with no clear, single shared function connecting the proteins. Therefore, this cluster appears functionally heterogeneous, warranting an Unknown label.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":3},{"id":"GO:1990573","count":2},{"id":"GO:0090528","count":2},{"id":"GO:1901223","count":2},{"id":"GO:0016058","count":1}]},{"hash":"2087474814383180310","title":"ER protein folding and redox homeostasis","description":"The cluster is dominated by GO terms for protein folding in the ER lumen, retention of proteins in the ER, and cellular oxidative stress/redox homeostasis, with prolyl hydroxylation linking to ER function. While DNA-templated transcription terms appear, the strongest signals point to ER-associated quality control and redox balance as the shared theme. Therefore this label reflects the core function of the cluster.","confidence":"High","size":21,"edges":50,"triangles":25,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":13},{"id":"GO:0034975","count":13},{"id":"GO:0034599","count":12},{"id":"GO:0045454","count":11},{"id":"GO:0055114","count":10}]},{"hash":"784170146454803567","title":"Gonadal development and steroid biosynthesis","description":"The top GO terms center on female reproductive development (uterus, female gonad/genitalia development) and on steroid-related metabolism (testosterone biosynthesis, cholesterol and vitamin D catabolic processes, brassinosteroid biosynthesis). This points to a cluster involved in gonadal development and steroid hormone production/metabolism, with broader lipid/xenobiotic catabolic activities as part of its metabolic capacity.","confidence":"Medium","size":21,"edges":8,"triangles":0,"max_degree":4,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0060065","count":18},{"id":"GO:1900087","count":15},{"id":"GO:0008585","count":15},{"id":"GO:0019383","count":15},{"id":"GO:0061370","count":15}]},{"hash":"806174880919687226","title":"Neurodevelopmental and Organogenesis Signaling","description":"The cluster's top GO terms strongly emphasize nervous system development and neurogenesis, with signaling pathways such as Roundabout signaling and Smoothened signaling that regulate neural patterning and organogenesis across tissues (including kidney and vagina development). Although there are immune-related terms present, the dominant theme is developmental signaling governing neural and organ formation.","confidence":"High","size":21,"edges":199,"triangles":1139,"max_degree":20,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007399","count":14},{"id":"GO:0035385","count":13},{"id":"GO:0042517","count":13},{"id":"GO:0006915","count":13},{"id":"GO:0007224","count":13}]},{"hash":"138202320118649754","title":"Neuronal development and microtubule regulation","description":"This cluster is driven by neural development signals (neuron development, dentate gyrus development, thigmotaxis) and microtubule/cytoskeleton regulation (alpha-tubulin acetylation, regulation of microtubule cytoskeleton organization). A few outliers related to chromatin, adipogenesis, angiogenesis, DNA replication, and inflammasome assembly appear but do not define the core pattern.","confidence":"High","size":21,"edges":10,"triangles":0,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048666","count":10},{"id":"GO:0045598","count":7},{"id":"GO:0071929","count":7},{"id":"GO:0001966","count":7},{"id":"GO:0021542","count":7}]},{"hash":"276257348664570995","title":"Ribosome biogenesis and mitotic cell cycle","description":"This cluster is dominated by GO terms for ribosome biogenesis and translation initiation, plus several mitosis-related terms (cell cycle, mitotic cytokinesis, cell division), suggesting a set of proteins coordinating protein synthesis with cell division. While mitochondrial fission and neuron projection development appear, the core theme centers on growth and division machinery.","confidence":"Medium","size":21,"edges":58,"triangles":59,"max_degree":13,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":6},{"id":"GO:0007049","count":6},{"id":"GO:0000281","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0000747","count":5}]},{"hash":"957870296032846760","title":"Spinal cord and heart development with morphogenesis","description":"The top GO terms cluster around developmental processes and morphogenesis, notably spinal cord development, heart development, and cell morphogenesis, with supporting terms for germ cell development and cytoskeletal/ signaling aspects. This points to a cohesive theme of developmental programs across neural and cardiovascular contexts, with links to neuronal structure and signaling.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0021510","count":5},{"id":"GO:0000902","count":5},{"id":"GO:1903423","count":4},{"id":"GO:0070493","count":4},{"id":"GO:0007281","count":4}]},{"hash":"1943910596248828864","title":"Redox Homeostasis and Oxidative Stress Response","description":"This cluster is dominated by GO terms for cellular oxidant detoxification, redox homeostasis, and oxidative stress response (including protein deglutathionylation), indicating a core function in maintaining cellular redox balance. A few terms for methylamine and triglyceride metabolism appear secondary, but overall the proteins appear enriched for redox regulation and stress-response pathways.","confidence":"High","size":21,"edges":207,"triangles":1274,"max_degree":20,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0098869","count":12},{"id":"GO:0045454","count":12},{"id":"GO:0030416","count":9},{"id":"GO:0055114","count":8},{"id":"GO:0006641","count":5}]},{"hash":"1513368212443596570","title":"RNA Splicing and Translation Regulation","description":"Most terms point to RNA processing and control of gene expression at both splicing and translation steps. Recurrent GO terms include positive regulation of mRNA splicing via spliceosome, cis-splicing, splice site recognition, mRNA export from nucleus, mRNA stability, and mRNA translation initiation (preinitiation complex formation, translation reinitiation). The presence of regulatory ncRNA-mediated gene silencing also aligns with RNA-level regulation. Therefore, the cluster is best described as RNA splicing and translation regulation.","confidence":"High","size":21,"edges":7,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":12},{"id":"GO:0031047","count":12},{"id":"GO:1901407","count":12},{"id":"GO:0002188","count":12},{"id":"GO:0001731","count":12}]},{"hash":"1169313666404764388","title":"Ribosome biogenesis and rRNA processing","description":"Dominant signals are ribosome biogenesis, maturation of LSU and 5.8S rRNA, and preribosome large-subunit assembly, with supporting links to RNA processing and transcription, indicating a nucleolar, ribosome-production\u2013focused cluster. Also compatible with cell cycle coordination. ","confidence":"High","size":21,"edges":38,"triangles":41,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000463","count":5},{"id":"GO:0000466","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0000398","count":4}]},{"hash":"1267611169987815088","title":"Glial inflammatory signaling and chromatin regulation","description":"Top GO terms cluster around astrocyte activation, inflammatory cytokine production (IL-1 alpha), and innate immune responses (lipopolysaccharide), alongside hypoxia response and chromatin-associated transcriptional regulation. This pattern points to a module of glial (astrocyte) driven inflammatory signaling that is controlled at the chromatin level, especially under CNS stress or injury.","confidence":"High","size":21,"edges":205,"triangles":1241,"max_degree":20,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0000122","count":15},{"id":"GO:0051290","count":13},{"id":"GO:0071169","count":8},{"id":"GO:0048143","count":7},{"id":"GO:0071456","count":7}]},{"hash":"1499786844710217971","title":"ER-Golgi vesicle transport","description":"The top GO terms cluster around vesicle trafficking between the endoplasmic reticulum and Golgi, plus general intracellular transport, indicating these proteins likely participate in ER-Golgi vesicle trafficking (and related intracellular transport). TORC1 signaling and translation initiation terms suggest potential coordination between trafficking, nutrient signaling, and protein synthesis, but the dominant theme remains ER-Golgi vesicle transport.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006890","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0038202","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0070262","count":4}]},{"hash":"357383189957495324","title":"Angiogenesis and immune cell chemotaxis signaling","description":"The cluster shows enrichment for angiogenesis (GO:0045766), monocyte and neutrophil chemotaxis, ERK/MAPK signaling (ERK1/ERK2 cascades), and tissue remodeling (collagen biosynthesis), along with responses to hypoxia and toxins, suggesting a unit involved in vascular remodeling and immune cell recruitment mediated by MAPK signaling.","confidence":"High","size":21,"edges":53,"triangles":46,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":5},{"id":"GO:0008344","count":4},{"id":"GO:0002548","count":4},{"id":"GO:1902230","count":3},{"id":"GO:0070374","count":3}]},{"hash":"902955361226159747","title":"Neuronal signaling and sensory processing","description":"Based on the top GO terms, the cluster is enriched for neuron-to-neuron signaling and sensory processing: dopaminergic synaptic transmission, visual perception and learning, sensory perception of pain, and responses to cocaine, with regulation of ERK signaling and GTPase activity. A heart development term appears but the dominant theme is neural communication and sensory/behavioral processing, justifying a label focused on neuronal signaling.","confidence":"High","size":21,"edges":158,"triangles":583,"max_degree":19,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":19},{"id":"GO:0070374","count":18},{"id":"GO:0048148","count":18},{"id":"GO:0010759","count":18},{"id":"GO:0019233","count":18}]},{"hash":"153800084668202453","title":"Thermal and pain response cluster","description":"Based on the top GO terms, the dominant signals are sensory perception of pain, cellular response to temperature stimulus, and diet-induced thermogenesis, suggesting a shared role in thermal/pain signaling and heat-related metabolic regulation. Other terms like heart and retina development and endothelial barrier regulation are less represented, so the strongest common theme is thermal and pain response.","confidence":"Medium","size":21,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":18},{"id":"GO:0002024","count":18},{"id":"GO:0071502","count":18},{"id":"GO:0043311","count":17},{"id":"GO:0060427","count":17}]},{"hash":"1303221379460836730","title":"Temperature-Responsive GPCR-cAMP Signaling","description":"This cluster centers on temperature-related processes (sensory pain, diet-induced thermogenesis, cellular response to temperature) and GPCR-mediated activation of adenylate cyclase, suggesting coordinated thermogenic signaling alongside energy metabolism (electron transport chain). While immune-related and lung-development terms appear, they may reflect tissue context and broad physiological roles of GPCR-cAMP pathways in temperature and cardiovascular responses.","confidence":"Medium","size":21,"edges":10,"triangles":1,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":18},{"id":"GO:0002024","count":18},{"id":"GO:0071502","count":18},{"id":"GO:0007190","count":17},{"id":"GO:0045777","count":17}]},{"hash":"2096429008801724309","title":"Dopaminergic signaling and cocaine response","description":"The cluster is dominated by terms related to neural signaling and reward/drug response, especially dopaminergic synaptic transmission and behavioral responses to cocaine, with ERK cascade involvement downstream of dopamine signaling and related neural processes like visual perception/learning. While there are a few immune- or development-associated terms in the set, the strongest cohesive theme centers on dopaminergic neuronal signaling and cocaine-related behavior.","confidence":"Medium","size":21,"edges":61,"triangles":10,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":16},{"id":"GO:0070374","count":16},{"id":"GO:0048148","count":16},{"id":"GO:0010759","count":16},{"id":"GO:0019233","count":16}]},{"hash":"840453042464709392","title":"Embryonic Morphogenesis and Muscle/Osteoblast Differentiation","description":"The cluster is enriched for terms related to vertebrate embryonic development and tissue differentiation, including morphogenesis of viscerocranium and outflow tract, primitive streak formation, roof of the mouth, and muscle and osteoblast differentiation. While one plant-specific term appears, the overall pattern centers on embryonic tissue formation and lineage specification, supported by transcriptional regulation and calcium signaling involvement.","confidence":"High","size":21,"edges":197,"triangles":1116,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0010076","count":11},{"id":"GO:0048703","count":10},{"id":"GO:0090009","count":10},{"id":"GO:0060021","count":10}]},{"hash":"1402088587229666105","title":"Vertebrate organ and neural development","description":"The GO terms point to development across multiple vertebrate organs and neural structures (brain/forebrain, retina, heart, gonads) along with transcriptional regulation and signaling (DNA-templated transcription, Wnt regulation, phosphorylation). This suggests a broad developmental program rather than a single pathway, so a label focusing on vertebrate organ and neural development fits well.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0016310","count":2},{"id":"GO:0008585","count":2},{"id":"GO:0030111","count":2}]},{"hash":"1389871696693708134","title":"Developmental transcription and cell-cycle regulation","description":"These proteins cluster around transcriptional control during development and cell-cycle progression. The frequent terms point to DNA-templated transcription, mRNA export, forebrain development, and multicellular growth, along with mitotic cell cycle and centrosome localization. Signaling inputs such as TGF-beta response and regulation of peptidyl-tyrosine phosphorylation likely coordinate transcription with cell division in development.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071560","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0006406","count":3},{"id":"GO:0030900","count":3}]},{"hash":"1891230045113705698","title":"RNA splicing and mRNA stability regulation","description":"This cluster is dominated by post-transcriptional gene regulation terms: spliceosome-mediated mRNA processing, splice site recognition, mRNA stabilization, and regulatory ncRNA-mediated silencing, plus regulation of mRNA stability in response to stress. While a few terms hint at other biology (keratinization, estrogen signaling, differentiation), the strongest signal is RNA processing and transcript stability, suggesting the proteins work together in RNA maturation and control of mRNA fate.","confidence":"Medium","size":21,"edges":20,"triangles":7,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031424","count":8},{"id":"GO:0030520","count":5},{"id":"GO:0048026","count":5},{"id":"GO:0031047","count":5},{"id":"GO:0010610","count":5}]},{"hash":"530653279174275912","title":"Kinase-regulated cell cycle and differentiation","description":"The cluster\u2019s top GO terms cluster around kinase-driven regulation (peptidyl-threonine phosphorylation, CDK activity regulation), centrosome cycle control, and telomere maintenance, with accompanying RNA processing and differentiation programs (neuron and adipocyte development). This pattern points to proteins that coordinate cell division with gene expression and developmental differentiation signals, rather than a single, unified pathway.","confidence":"Medium","size":21,"edges":20,"triangles":0,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0007098","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0048666","count":3},{"id":"GO:0045444","count":3}]},{"hash":"1858120220485084229","title":"Organogenesis signaling and adhesion","description":"The cluster prominently features organ development terms (kidney development, nervous system development) together with major signaling pathways (BMP, Smoothened/Shh, STAT tyrosine phosphorylation) and both homophilic and heterophilic cell adhesion. This combination indicates a group of proteins coordinating tissue patterning, signaling cascades, and cell\u2013cell interactions during organogenesis. Angiogenesis also appears, consistent with developmental blood vessel formation.","confidence":"High","size":21,"edges":109,"triangles":231,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001822","count":10},{"id":"GO:0042517","count":10},{"id":"GO:0007156","count":10},{"id":"GO:0007157","count":10},{"id":"GO:0001525","count":9}]},{"hash":"2034215433750473722","title":"Embryonic Development & Organogenesis","description":"This cluster\u2019s top GO terms point to broad embryonic development and tissue formation across multiple lineages (heart/endocardial cushion EMT, placenta and endocrine system development, cartilage morphogenesis, left-right patterning, pancreatic cell development, serotonergic axon guidance). Even with no observed edges, the common theme is developmental differentiation and organ formation, justifying a label centered on embryogenesis and organogenesis.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060972","count":3}]},{"hash":"1312503617648741551","title":"Unknown","description":"This cluster\u2019s top GO terms cover diverse areas\u2014lipid catabolism (triglyceride), plant secondary metabolism (alkaloids, stilbenes, strigolactone biosynthesis), and neural/immune signaling (paranodal junction assembly, receptor internalization, synapse organization, T cell costimulation, MAPK activation). There isn\u2019t a clear, single function uniting these terms, so a specific label isn\u2019t justifiable.","confidence":"","size":21,"edges":63,"triangles":76,"max_degree":20,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0019433","count":10},{"id":"GO:0030913","count":7},{"id":"GO:0031623","count":6},{"id":"GO:0031295","count":6},{"id":"GO:0000187","count":6}]},{"hash":"1830054956184939859","title":"Ubiquitin-Dependent Protein Degradation","description":"The cluster is dominated by ubiquitination-related GO terms (ubiquitin-dependent protein catabolic process, protein ubiquitination, autoubiquitination, K48-linked ubiquitination, ERAD pathway), indicating a cohesive group of proteins centered on ubiquitin signaling and proteasomal degradation. Some hits also touch on degradation-regulated signaling (Wnt receptor catabolic process, regulation of organ growth), which aligns with the degradation theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0051865","count":11},{"id":"GO:0070936","count":10},{"id":"GO:0030433","count":10},{"id":"GO:1901253","count":10}]},{"hash":"536947875852036818","title":"Cardiovascular development and heart electrophysiology","description":"Reasoning: The prominent terms cluster around cardiovascular tissue formation and function\u2014endothelial differentiation, epithelial polarity in vessels, actin-driven cell migration, and regulation of cardiac action potentials. A few terms related to pain signaling and innate immunity are less connected and may reflect broader cellular regulation. The core theme is cardiovascular development and heart electrophysiology.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051017","count":7},{"id":"GO:0016477","count":7},{"id":"GO:0016567","count":7},{"id":"GO:0090162","count":6},{"id":"GO:0098907","count":6}]},{"hash":"116301235278319825","title":"Neuroimmune signaling and axon guidance","description":"The cluster shows strong enrichment for semaphorin-plexin signaling and neuron projection guidance, indicating axon guidance functions. It also includes multiple immune-related terms\u2014antigen processing and presentation via MHC I, regulation of NK cell cytotoxicity, and regulation of cytotoxic T cell degranulation\u2014pointing to immune modulation. Together, these terms suggest a theme of neuroimmune signaling and neural guidance with associated immune regulation.","confidence":"Medium","size":21,"edges":8,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001798","count":12},{"id":"GO:0048672","count":12},{"id":"GO:0000187","count":12},{"id":"GO:0042590","count":12},{"id":"GO:0001805","count":12}]},{"hash":"122236171174662828","title":"Embryonic and Organ Development","description":"The GO terms are dominated by developmental processes across multiple organs (heart, brain/midbrain, eye, placenta, prostate, gonad) and morphogenesis, with a note on transcriptional regulation, indicating a general developmental program rather than a single tissue-specific function.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":8},{"id":"GO:0048048","count":8},{"id":"GO:0000122","count":8},{"id":"GO:2000288","count":7},{"id":"GO:0021986","count":7}]},{"hash":"1393360091324689235","title":"Pain-Inflammation and Vasomotor Regulation","description":"This cluster centers on nociception and inflammatory signaling, with terms for sensory perception of pain, inflammatory response, and LPS response, plus vascular and smooth muscle regulation (vasoconstriction and calcium-triggered contraction), blood coagulation, and thermogenic/temperature-responsive processes, suggesting a module linking pain perception with immune activation and vascular tone.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0007596","count":7},{"id":"GO:0051209","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0071502","count":7}]},{"hash":"435364387789018458","title":"ECM Remodeling and Tissue Development","description":"The GO terms center on collagen catabolic process, extracellular matrix disassembly, and tissue remodeling, with additional signals from blood coagulation and complement activation, which are typical of wound healing contexts involving ECM changes. Developmental pathways like the Wnt signaling pathway and midbrain development further support a theme of ECM-associated tissue development. A note on transcriptional regulation is present but seems secondary to the core ECM/development axis. Overall, the cluster appears to group proteins involved in extracellular matrix remodeling linked to developmental and wound-healing processes.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0007596","count":6},{"id":"GO:0030574","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0006958","count":6}]},{"hash":"1557399431445355570","title":"Embryonic Development and Organ Morphogenesis","description":"This cluster highlights embryonic and tissue morphogenesis across many systems, including midbrain development, left-right pattern formation, cartilage morphogenesis, placenta and endocrine system development, pancreatic cell development, EMT in endocardial cushion formation, trophoblast differentiation, and angiogenesis (the immune term is likely a misannotation).","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0060972","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0035270","count":4}]},{"hash":"1454556211908389908","title":"Rho-GTPase\u2013driven actin remodeling","description":"The top GO terms center on Rho-regulated signaling and GTPase activity, actin cytoskeleton reorganization and crosslinking, and microfilament-driven processes like nuclear migration, with additional links to development and brain formation, suggesting a cohesive theme of actin dynamics controlled by Rho pathways.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0031532","count":4},{"id":"GO:0051764","count":4},{"id":"GO:0031022","count":4}]},{"hash":"1269429495871320936","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"This cluster is dominated by GO terms related to actin cytoskeleton organization, filopodium and lamellipodium assembly, and Rac-mediated signaling, all core components of cell motility and adhesion-driven spreading. The presence of insulin signaling and some development/immune terms is secondary and likely incidental, but does not override the central theme of cytoskeletal dynamics driving cell movement. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":4},{"id":"GO:0030036","count":4},{"id":"GO:0046847","count":4},{"id":"GO:1900026","count":4},{"id":"GO:0035020","count":4}]},{"hash":"637328517394515253","title":"Actin Cytoskeleton Remodeling and Adhesion","description":"This cluster is dominated by GO terms tied to actin dynamics and cell interactions, including actin cytoskeleton reorganization, microspike assembly, actin crosslinking, regulation of Rho signaling, cell adhesion, and cell polarity/morphology, with additional links to endocytosis and mitotic spindle assembly. The recurring theme is remodeling of the actin cytoskeleton to control cell shape, adhesion, trafficking, and morphogenesis, making this label representative of the cluster\u2019s functions.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0031532","count":6},{"id":"GO:0007155","count":6},{"id":"GO:0035023","count":6},{"id":"GO:1900042","count":5},{"id":"GO:0030035","count":5}]},{"hash":"2245393408831984490","title":"Synaptic vesicle trafficking and neurotransmitter release","description":"GO terms indicate a cohesive theme of neuronal vesicle transport, including Golgi-endosome pathways, endosome-to-melanosome routes, presynaptic dense core vesicle exocytosis, neurotransmitter secretion, and synaptic vesicle maturation, pointing to a shared function in neuronal vesicle trafficking and release.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":5},{"id":"GO:1901998","count":4},{"id":"GO:0006895","count":3},{"id":"GO:0035646","count":3},{"id":"GO:0048227","count":2}]},{"hash":"1282389890840268629","title":"Unknown","description":"The GO terms include ectopic germ cell programmed cell death, skeletal system development, axon guidance signaling, proteolysis, Kit signaling, trigeminal nerve organization, IL-2 production, innate immune response, and B cell receptor signaling. They cover development, neural signaling, immune signaling, and proteolysis without a clear single shared function or pathway, making a cohesive, specific label unreliable.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035234","count":4},{"id":"GO:0001501","count":4},{"id":"GO:1902287","count":4},{"id":"GO:0006508","count":4},{"id":"GO:0043552","count":4}]},{"hash":"654573829667141495","title":"Excitatory synapse assembly and AMPA receptor regulation","description":"The terms cluster around dendritic spine morphogenesis, PSD assembly, AMPA receptor clustering, and regulation of glutamatergic synaptic transmission and plasticity, pointing to a shared role in building and modulating excitatory synapses and their receptor organization.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":5},{"id":"GO:0051968","count":4},{"id":"GO:0048170","count":4},{"id":"GO:2000463","count":4},{"id":"GO:1904717","count":4}]},{"hash":"474086787783971734","title":"Immune Signaling and Organ Development","description":"The cluster combines immune-related GO terms (positive regulation of eosinophil degranulation, positive regulation of neutrophil killing of gram-negative bacteria, dendritic cell chemotaxis, response to lipopolysaccharide) with organ-development terms (lung connective tissue development, retina development in camera-type eye, heart development, endothelial barrier modulation), plus general signaling (adenylate cyclase activation, calcium signaling). This suggests a cohesive theme of immune signaling linked to multi-organ development processes, rather than a single, narrow function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":19},{"id":"GO:0060427","count":19},{"id":"GO:0070963","count":19},{"id":"GO:0051482","count":19},{"id":"GO:0060041","count":19}]},{"hash":"2293685037862009298","title":"Chemosensory Taste Perception and Pheromone Signaling","description":"Proteins are enriched for taste and chemical stimulus detection, including bitter taste, and for pheromone response and neuropeptide signaling, suggesting a core function in chemosensory sensing and signaling. Some immune and tissue development terms appear but are less central to the cluster\u2019s main theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050909","count":9},{"id":"GO:0007606","count":9},{"id":"GO:0001580","count":9},{"id":"GO:0019236","count":9},{"id":"GO:0008542","count":8}]},{"hash":"1203525371945607930","title":"Developmental signaling and tissue morphogenesis","description":"The terms point to developmental pathways (Wnt signaling, spermatogenesis, meiosis, skin development) and processes of tissue formation, along with muscle/heart regulation and cell migration. This suggests a broad theme of signaling and morphogenesis across tissues rather than a single specific function, justifying a label centered on development and tissue differentiation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035994","count":4},{"id":"GO:0010881","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0098907","count":3},{"id":"GO:0016477","count":3}]},{"hash":"1708211331370567357","title":"Embryogenesis and tissue morphogenesis","description":"The proteins are enriched for GO terms describing embryonic development, patterning, and morphogenesis across diverse tissues (endocrine system, placenta, mesoderm, cartilage, hair follicles, EMT in heart). This suggests a broad developmental program underlying organ formation rather than a single pathway, so the label reflects both embryogenesis and tissue morphogenesis.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035270","count":21},{"id":"GO:0060972","count":21},{"id":"GO:0060806","count":21},{"id":"GO:0003323","count":21},{"id":"GO:0060536","count":21}]},{"hash":"865961386816632343","title":"Ubiquitin-Dependent Protein Degradation","description":"Dominant GO terms are ubiquitination and ubiquitin\u2011dependent protein catabolic process, indicating this cluster centers on tagging substrates for degradation. Other enriched terms suggest related signaling and stress responses, but ubiquitin-mediated turnover is the key theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0016567","count":7},{"id":"GO:0007205","count":6},{"id":"GO:0098907","count":6},{"id":"GO:0051225","count":6}]},{"hash":"2078128375411697374","title":"Ribosome Biogenesis and Translation","description":"The cluster is dominated by GO terms tied to ribosome assembly (small and large subunits), rRNA maturation, tRNA processing, and translation, highlighting a core function in ribosome biogenesis and protein synthesis. While a few terms involve deubiquitination and cell-cycle transitions, the prevailing signal centers on ribosome assembly and translation.","confidence":"High","size":20,"edges":67,"triangles":152,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0000028","count":3},{"id":"GO:0008033","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0000462","count":2}]},{"hash":"969951459962080378","title":"Central Carbon Metabolism and Translation","description":"This cluster shows strong representation of core metabolic pathways (glycolysis, TCA cycle, 2-oxoglutarate metabolism) along with amino-acid and fatty-acid related biosynthetic processes, suggesting a central carbon metabolism module. The presence of a translation term indicates some translation-related proteins are also present, implying a mixed cluster of metabolic enzymes and translation components. Overall, a name that captures both metabolism and translation components fits best.","confidence":"Medium","size":20,"edges":188,"triangles":1105,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006096","count":6},{"id":"GO:0006412","count":5},{"id":"GO:0006099","count":5},{"id":"GO:0033512","count":3},{"id":"GO:0042493","count":3}]},{"hash":"1692111859309783894","title":"Stress-Response Signaling in Development","description":"This cluster centers on GO terms related to cellular stress responses and signaling pathways (ischemia response, ER stress-induced apoptotic signaling, negative regulation of mitochondrial depolarization, JNK cascade regulation, and apoptosis), with additional development-related processes (hair follicle morphogenesis, thymus development) and immune-related activity (B cell proliferation). The common thread appears to be activation of stress- and signal-transduction pathways that intersect with developmental and cellular fate processes, rather than a single concrete tissue-specific function.","confidence":"Medium","size":20,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002931","count":2},{"id":"GO:0031103","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0014911","count":2},{"id":"GO:0031069","count":2}]},{"hash":"1689071036248724140","title":"Transmembrane nutrient transporters","description":"This cluster is dominated by GO terms for transmembrane transport of various substrates (phosphate, nitrate, sodium, sugars like arabinose and galactose, vitamins, and other metabolites) and includes a neurotransmitter loading into synaptic vesicle term, pointing to a cohesive group of membrane transport proteins involved in substrate uptake and vesicle loading. ","confidence":"High","size":20,"edges":60,"triangles":64,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035435","count":6},{"id":"GO:0042128","count":6},{"id":"GO:0035461","count":6},{"id":"GO:0015751","count":6},{"id":"GO:0035725","count":6}]},{"hash":"1661058407320518760","title":"Nuclear mRNA processing and export","description":"The cluster shows strong enrichment for mRNA splicing and spliceosome-related terms (splicing via spliceosome, splice site recognition, cis splicing), alongside mRNA stability, export from the nucleus, and regulatory aspects of mRNA processing, indicating a cohesive role in nuclear post-transcriptional processing and mRNA fate control.","confidence":"High","size":20,"edges":130,"triangles":498,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":12},{"id":"GO:0048026","count":10},{"id":"GO:0031047","count":10},{"id":"GO:0048255","count":9},{"id":"GO:0006376","count":9}]},{"hash":"1381028996883165767","title":"Aminergic neurotransmitter synthesis and vesicle loading","description":"This cluster shows enrichment for histamine and dopamine biosynthesis, and loading of aminergic neurotransmitters into synaptic vesicles, indicating a core role in aminergic neurotransmission. Some terms like translation and circadian rhythm are less specific, but the dominant pattern points to neuromodulator production and packaging for release.","confidence":"Medium","size":20,"edges":32,"triangles":52,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0035690","count":4},{"id":"GO:0001694","count":3},{"id":"GO:0071312","count":3},{"id":"GO:0015842","count":3}]},{"hash":"197702548027626114","title":"Lipid Biosynthesis and Mitochondrial Lipid Remodeling","description":"The top GO terms are dominated by lipid biosynthesis and remodeling processes (triglyceride, ether lipid, cardiolipin remodeling, phosphatidylcholine remodeling, CDP-diacylglycerol biosynthesis) and a mitochondria-associated process (mitochondrial ATP synthesis coupled electron transport), suggesting the cluster centers on lipid production and membrane lipid remodeling, particularly involving mitochondria; a couple of terms related to immune signaling appear incidental rather than central to the main theme.","confidence":"High","size":20,"edges":45,"triangles":29,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0019432","count":11},{"id":"GO:0008611","count":11},{"id":"GO:0010143","count":11},{"id":"GO:0042775","count":11},{"id":"GO:0035965","count":11}]},{"hash":"195098720854207614","title":"Ribosome biogenesis and translation machinery","description":"The top terms are dominated by ribosome biogenesis (small/large subunit), nuclear export, cytoplasmic translation, and translation, with supporting cell cycle/division terms, pointing to a cluster of proteins involved in ribosome assembly, export, and protein synthesis, closely tied to cell growth and division processes.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0007049","count":6},{"id":"GO:0042274","count":5},{"id":"GO:0000055","count":5},{"id":"GO:0002181","count":4}]},{"hash":"2000802224735843202","title":"Nephrogenesis and innate immune signaling","description":"This cluster is dominated by kidney development terms (metanephric proximal/distal tubule development, mesonephric duct development) alongside several innate-immune signaling pathways (complement activation via lectin pathway, Fc-gamma receptor signaling, stimulatory C-type lectin receptor signaling). The mix implies a group of proteins involved in nephrogenesis with concurrent engagement of innate immune signaling, rather than a single, cohesive non-developmental function. Confidence: Medium","confidence":"","size":20,"edges":76,"triangles":265,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0072237","count":13},{"id":"GO:0001867","count":13},{"id":"GO:0050901","count":13},{"id":"GO:0010572","count":13},{"id":"GO:0038094","count":13}]},{"hash":"765764277734389482","title":"Protein acetylation and chromatin regulation","description":"The top terms are dominated by various acetylation processes (peptidyl-lysine N6-acetylation and multiple N-terminal acetylations) and histone acetylation, with connected chromatin-related functions like centromeric cohesion and heterochromatin formation, pointing to an acetylation-driven role in chromatin maintenance.","confidence":"High","size":20,"edges":42,"triangles":29,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0018003","count":9},{"id":"GO:0017198","count":8},{"id":"GO:0018002","count":8},{"id":"GO:0032918","count":8},{"id":"GO:0043967","count":8}]},{"hash":"904077728333678997","title":"Actin-driven protrusions and migration","description":"This cluster is enriched for actin cytoskeleton remodeling terms, notably lamellipodium, filopodium, and microspike assembly, plus regulation of GTPase activity, pointing to actin-driven protrusions and cell motility. The presence of related processes like vesicle formation and immune cell movement fits under cytoskeletal dynamics guiding migration.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0090334","count":2},{"id":"GO:0070676","count":2},{"id":"GO:0043314","count":2},{"id":"GO:0060313","count":2}]},{"hash":"281065899248401254","title":"Chromatin remodeling and transcriptional regulation in development","description":"The cluster is enriched for histone modification and transcription regulation terms (histone acetylation/methylation, negative regulation of transcription), plus ubiquitin-dependent proteolysis, and development-related terms for skeletal muscle and seminiferous tubules. This points to a theme of chromatin-mediated control of gene expression during tissue development, possibly coordinating muscle and gonadal differentiation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0007519","count":5},{"id":"GO:0008584","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0043982","count":4}]},{"hash":"871327833261420244","title":"Neural development and axon guidance","description":"The proteins cluster around CNS wiring and development: axon guidance (retinal ganglion cell guidance, CNS projection neuron axonogenesis, corpus callosum development) and signaling pathways (ROBO/roundabout, receptor tyrosine kinases) paired with processes like myelination and synapse assembly; extracellular matrix organization (collagen fibril) also supports neural connectivity. Some terms also reflect neuronal migration and hormone-responsive signaling, all pointing to neural development and axon pathfinding as the core theme.","confidence":"High","size":20,"edges":105,"triangles":267,"max_degree":19,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0021836","count":10},{"id":"GO:0035385","count":10},{"id":"GO:0071372","count":10},{"id":"GO:0007169","count":10},{"id":"GO:0031290","count":10}]},{"hash":"1440727214910514775","title":"Rho GTPase signaling in neural and vascular development","description":"The cluster is dominated by GTPase activation and Rho signaling terms, indicating a cytoskeletal signaling focus; additional terms point to vascular processes (angiogenesis, endothelial barrier) and neural signaling/development (NMDA receptor regulation, nitric oxide signaling, spinal cord development, sensory perception). This suggests proteins linked by Rho-mediated signaling with roles in neurovascular development rather than a single, uniform function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090630","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0090557","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0001525","count":2}]},{"hash":"1418263114548089451","title":"Actin Cytoskeleton Remodeling and Membrane Dynamics","description":"This cluster centers on actin polymerization and lamellipodium/bundle formation, with positive regulation of actin assembly, together with signaling pathways that regulate the cytoskeleton (insulin receptor, integrin-mediated, TGF-beta). It also includes membrane remodeling processes like plasma membrane tubulation and caveola assembly, and a note on excitatory signaling (EPSP), pointing to coordinated cytoskeletal and membrane changes during signaling and adhesion. Overall, a cohesive theme of actin-driven remodeling coupled to membrane dynamics.","confidence":"High","size":20,"edges":18,"triangles":0,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0008286","count":11},{"id":"GO:0030041","count":10},{"id":"GO:0030838","count":10},{"id":"GO:0030032","count":10},{"id":"GO:0007229","count":9}]},{"hash":"1246182243665521384","title":"Neural Development Signaling","description":"The top GO terms center on developmental signaling pathways (Roundabout/Robo, Smoothened/Hedgehog) and nervous system development, including axon guidance and interneuron migration, with related organ development themes (heart, kidney). A subset touches ion channel organization and immune signaling, but the dominant theme is developmental signaling tied to neural processes. Confidence: Medium","confidence":"","size":20,"edges":161,"triangles":702,"max_degree":19,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035385","count":9},{"id":"GO:0007399","count":9},{"id":"GO:0007224","count":9},{"id":"GO:0001822","count":9},{"id":"GO:0050852","count":9}]},{"hash":"283400853476894080","title":"Unknown","description":"The top terms are diverse, covering membrane trafficking (caveolin-mediated endocytosis), signaling (JNK regulation), development (neuronal, mammary, cardiac), and various metabolic processes (sphingolipid, cytosine), with no single unifying function evident for the group. This lack of a cohesive theme justifies an Unknown label.","confidence":"","size":20,"edges":188,"triangles":1104,"max_degree":19,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0072584","count":20},{"id":"GO:0033598","count":20},{"id":"GO:1990804","count":20},{"id":"GO:0007098","count":20},{"id":"GO:0043506","count":20}]},{"hash":"1988894662697358359","title":"DNA replication and repair machinery","description":"Most prevalent GO terms cluster around DNA replication, DNA repair, and cell-cycle processes (mitotic cycle, centrosome cycle, transcription), suggesting these proteins function together in genome maintenance and regulation of cell division. Some terms (caveolin-mediated endocytosis, mammary gland proliferation) appear peripheral, possibly reflecting broader roles or annotation nuances.","confidence":"High","size":20,"edges":97,"triangles":198,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006281","count":20},{"id":"GO:0006260","count":20},{"id":"GO:0000278","count":20},{"id":"GO:0006351","count":20},{"id":"GO:0072584","count":19}]},{"hash":"1820430334782861187","title":"Cardiac GPCR-ERK Signaling and Thermogenesis","description":"This cluster shows strong signals for cardiovascular processes (blood pressure regulation, heart development) and GPCR-mediated pathways (adenylate cyclase-activating signaling) with downstream ERK1/2 cascade involvement. It also includes metabolism/thermogenesis-related terms (diet-induced thermogenesis, cellular response to temperature, electron transport chain, membrane potential regulation), suggesting a link between energy metabolism and cardiac signaling. Overall, the proteins likely participate in GPCR-driven signaling that couples metabolic/thermal cues to heart development and function via ERK signaling and mitochondrial energy production.","confidence":"Medium","size":20,"edges":12,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":17},{"id":"GO:0002024","count":15},{"id":"GO:0071502","count":15},{"id":"GO:0042391","count":14},{"id":"GO:0022900","count":12}]},{"hash":"792126036214198500","title":"Vision and neural signaling","description":"The top GO terms cluster around vision-related processes (visual perception, visual learning) and neural signaling (GPCR-cGMP signaling, ERK cascade, membrane potential regulation, cocaine behavioral response), suggesting a cohesive theme of sensory processing and neuronal signaling with vision as a focus. Some terms like heart development and macrophage chemotaxis are less central but may reflect shared signaling pathways; overall the cluster highlights neural/visual function rather than unrelated processes.","confidence":"High","size":20,"edges":107,"triangles":179,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":18},{"id":"GO:0019233","count":18},{"id":"GO:0007601","count":18},{"id":"GO:0042391","count":17},{"id":"GO:0070374","count":17}]},{"hash":"461763769791766286","title":"Neural signaling and sensory perception","description":"The top GO terms point to nervous system signaling and sensory processing: dopaminergic synaptic transmission, visual perception/learning, sensory perception of pain, cocaine response, and ERK signaling. While heart development and macrophage chemotaxis appear among terms, the predominant theme is neural signaling and sensory functions, with signaling pathways like protein phosphorylation/ERK taking a supporting role.","confidence":"High","size":20,"edges":164,"triangles":755,"max_degree":19,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":18},{"id":"GO:0070374","count":18},{"id":"GO:0048148","count":18},{"id":"GO:0010759","count":18},{"id":"GO:0019233","count":18}]},{"hash":"114147174507590072","title":"Muscle structure and contraction regulation","description":"This cluster is dominated by GO terms related to muscle biology\u2014muscle attachment, regulation of skeletal and cardiac muscle contraction via calcium signaling, and proliferative regulation\u2014indicating a focus on muscle structure and function. Supporting terms on protein localization, nuclear regulation, and epigenetic modification suggest regulatory processes that govern muscle development and gene expression. The olfactory nerve term appears as a less representative outlier, but the overall theme centers on muscle structure and its control. ","confidence":"Medium","size":20,"edges":99,"triangles":227,"max_degree":15,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0021629","count":10},{"id":"GO:0016203","count":10},{"id":"GO:0030512","count":10},{"id":"GO:2000009","count":10},{"id":"GO:0014809","count":10}]},{"hash":"1627284757375278911","title":"Pain and Temperature Sensing with Immune Response","description":"The top terms cluster around nociception and thermosensation (sensory perception of pain; cellular response to temperature stimulus; diet-induced thermogenesis) and extend to membrane potential regulation and neutrophil/eosinophil degranulation, suggesting a theme of sensory/thermal signaling linked to inflammatory/immune responses. Although there are broader development terms present, the dominant pattern is pain/temperature sensing intertwined with immune activity, justifying this label.","confidence":"Medium","size":20,"edges":44,"triangles":16,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":19},{"id":"GO:0018298","count":19},{"id":"GO:0002024","count":19},{"id":"GO:0071502","count":19},{"id":"GO:0042391","count":18}]},{"hash":"2262284941973114517","title":"GPCR-AC Signaling and Thermogenesis","description":"The cluster centers on GPCR-mediated activation of adenylate cyclase and cAMP signaling, with strong ties to energy metabolism processes (electron transport chain) and thermogenesis (diet-induced, temperature response). This points to a unified theme of metabolic signaling and heat production, while also showing secondary enrichment in immune and respiratory tissue regulation, indicating broader physiological coordination in energy, defense, and respiration.","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":14},{"id":"GO:0007190","count":14},{"id":"GO:0010579","count":14},{"id":"GO:0045777","count":14},{"id":"GO:0019233","count":13}]},{"hash":"2239609376825119108","title":"Fatty acid biosynthesis and lipid metabolism","description":"The top GO terms are dominated by fatty acid\u2013related processes (fatty acid biosynthesis, long-chain/very long-chain fatty acid metabolism, medium-chain fatty-acyl-CoA metabolism, fatty-acid transport) and lipid biosynthesis like lipoteichoic acid and menaquinone biosynthesis. These indicate a cohesive theme around lipid production and fatty acid utilization, with a few aromatic metabolism terms possibly reflecting broader metabolic context rather than core function. ","confidence":"High","size":20,"edges":184,"triangles":1038,"max_degree":19,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006633","count":13},{"id":"GO:0009234","count":11},{"id":"GO:0001676","count":11},{"id":"GO:0090410","count":11},{"id":"GO:0001579","count":11}]},{"hash":"328172130390835754","title":"Innate Immunity and Translation Initiation Regulation","description":"The top GO terms cluster around innate immune signaling (MyD88-dependent TLR signaling, LPS signaling, dsRNA response, innate immune response, IFN-\u03b2 production) and translational control (formation of translation preinitiation complex, regulation of translational initiation, viral translational termination-reinitiation), suggesting a set of proteins that link antiviral signaling with regulation of protein synthesis. The dopamine-related term seems incidental rather than central. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:1903351","count":3},{"id":"GO:0002755","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0045087","count":3}]},{"hash":"2291395174513144891","title":"Immune cell granule exocytosis and vesicle trafficking","description":"The top GO terms cluster around degranulation in eosinophils, neutrophils, NK cells, and mast cells, plus intracellular vesicle transport and receptor recycling. This points to secretory granule release and vesicle trafficking as the core theme in this cluster, with insulin response and channel regulation likely reflecting broader signaling connections to vesicle dynamics.","confidence":"High","size":20,"edges":21,"triangles":1,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":3},{"id":"GO:0043308","count":3},{"id":"GO:0043312","count":3},{"id":"GO:0043320","count":2},{"id":"GO:1900483","count":2}]},{"hash":"1127915867686142323","title":"Circadian Regulation of Gene Expression","description":"Top GO terms indicate strong enrichment for circadian rhythm regulation and light-responsive transcription, including DNA-templated transcription and phototransduction, with additional hormone-responsive transcription modulation. This suggests a cohesive theme of circadian- and light-driven transcriptional control, with some related developmental and chromatin remodeling signals.","confidence":"High","size":20,"edges":185,"triangles":1056,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":19},{"id":"GO:0070932","count":18},{"id":"GO:0032922","count":18},{"id":"GO:0042753","count":18},{"id":"GO:0071386","count":17}]},{"hash":"2116873172501054254","title":"GTPase-Driven Cytoskeleton and Polarity Signaling","description":"The cluster emphasizes small GTPase\u2013mediated signaling and cytoskeletal regulation (actin crosslinking, endocytosis) alongside cell polarity establishment and maintenance. It also includes links to muscle-related signaling (skeletal muscle fiber development; ERK and NFAT pathways) suggesting coordination between cytoskeleton dynamics and signaling in muscle and epithelial contexts. This points to a cohesive theme of GTPase-regulated cytoskeleton remodeling coupled with polarity signaling.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0048741","count":5},{"id":"GO:0090162","count":4},{"id":"GO:0007264","count":4},{"id":"GO:0010801","count":4}]},{"hash":"801469521035524481","title":"Camera-type eye and retina morphogenesis","description":"This cluster shows strong enrichment for eye-related development terms (camera-type eye development, retina development, embryonic eye morphogenesis, embryonic digestive tract morphogenesis) and related morphogenesis processes, with some transcription regulation signals. The prominent theme across proteins appears to be ocular development and retinal morphogenesis, making this label representative of the cluster\u2019s function.","confidence":"High","size":20,"edges":135,"triangles":431,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":14},{"id":"GO:0060441","count":13},{"id":"GO:0043010","count":12},{"id":"GO:0048048","count":12},{"id":"GO:0000122","count":11}]},{"hash":"1441751954527619027","title":"Biosynthesis, Catabolism, and Detoxification","description":"This cluster's top GO terms cluster around biosynthetic and degradative metabolic processes (biotin, antibiotic, menaquinone biosynthesis; beta-ketoadipate pathway; cellulose and chlorophyll catabolism) as well as cellular detoxification and xenobiotic response. While two RNA-processing terms (mRNA capping and guanine-N7 methylation) are present, the dominant signal points to coordinated metabolism and stress-related turnover rather than a single specific pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0009102","count":8},{"id":"GO:0017000","count":8},{"id":"GO:0098869","count":7},{"id":"GO:0042493","count":5},{"id":"GO:0036265","count":5}]},{"hash":"1938264844334086124","title":"Developmental Differentiation and Sensory Morphogenesis","description":"This cluster centers on embryonic development and morphogenesis across multiple tissues (forebrain, skeletal muscle, cochlea, visual system) with related signaling (Wnt regulation, receptor clustering) and differentiation processes, suggesting a theme of developmental differentiation and sensory organ formation. The DNA repair terms appear ancillary rather than defining.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051103","count":3},{"id":"GO:0006303","count":3},{"id":"GO:0060707","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0000122","count":2}]},{"hash":"2281908640500054741","title":"Actin remodeling and clathrin-mediated endocytosis","description":"This cluster shows strong enrichment for actin cytoskeleton dynamics (filopodium assembly, barbed-end actin filament capping, Arp2/3 regulation) and membrane trafficking/endocytosis processes (clathrin coat assembly, positive/negative regulation of receptor-mediated endocytosis). A few terms touch unrelated processes (subtelomeric heterochromatin formation, megakaryocyte development, apoptosis), but the dominant theme centers on actin-driven remodeling and endocytosis, supporting this label.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":4},{"id":"GO:0006348","count":3},{"id":"GO:0035855","count":3},{"id":"GO:0051016","count":3},{"id":"GO:0034316","count":2}]},{"hash":"2000782931436837109","title":"Embryonic development and organogenesis","description":"The proteins are linked to multiple developmental processes across tissues (primitive streak formation, telencephalon regionalization, retina development, pituitary and gonad development, PNS neuron development, digestive tract development, and ureteric bud morphogenesis). The presence of transcriptional regulation terms (negative regulation of transcription by RNA polymerase II) alongside these developmental processes suggests coordinated gene expression control during embryogenesis, pointing to a theme of early development and organ formation.","confidence":"High","size":20,"edges":12,"triangles":0,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":14},{"id":"GO:0090009","count":11},{"id":"GO:0021983","count":10},{"id":"GO:0008584","count":10},{"id":"GO:0007275","count":10}]},{"hash":"1968670729811371949","title":"Thermo-sensory and neural signaling","description":"This cluster\u2019s top GO terms center on temperature and pain perception, thermogenic responses, and neural signaling (including membrane potential regulation and retina/visual learning). Together these suggest a coherent theme of sensory processing and neural circuit function across somatic and visual systems. A few immune-related terms appear but do not define the cluster\u2019s main function. Confidence: Medium.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":17},{"id":"GO:0002024","count":17},{"id":"GO:0071502","count":17},{"id":"GO:0042391","count":16},{"id":"GO:0008542","count":16}]},{"hash":"1685982520337032593","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0048485","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0007275","count":3}]},{"hash":"1003526557974714088","title":"Sensory Perception and Neuronal Signaling","description":"The top GO terms cluster around sensory detection (sweet taste) and sensory-driven movement (phototaxis, lateral line development) along with a signaling pathway (GABA). An energy metabolism term (electron transport chain) fits as the cellular energy needed for signaling processes. While some terms are generic or obsolete, the dominant theme across the cluster is sensory perception and neural signaling.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001582","count":19},{"id":"GO:0000187","count":19},{"id":"GO:0042331","count":19},{"id":"GO:0048899","count":19},{"id":"GO:0007214","count":19}]},{"hash":"1183543673897194301","title":"Innate Immune Signaling and Inflammation","description":"The top GO terms highlight immune cell functions and responses (eosinophil degranulation, neutrophil-mediated killing of Gram-negative bacteria, dendritic cell chemotaxis, response to lipopolysaccharide). These point to innate immune activation and inflammatory signaling as the core pattern. A subset of terms about development of lung, retina, heart, and endothelial barrier may reflect broader signaling roles or tissue remodeling, but they do not override the immune-focused terms. Thus the label emphasizes innate immune signaling as the cluster's main theme.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":20},{"id":"GO:0060427","count":20},{"id":"GO:0070963","count":20},{"id":"GO:0051482","count":20},{"id":"GO:0060041","count":20}]},{"hash":"1788168643645714262","title":"RNA Pol II transcription initiation and regulation","description":"The cluster is enriched for GO terms centered on RNA polymerase II transcription initiation, preinitiation complex assembly, and regulation of Pol II transcription, indicating proteins involved in the transcription initiation machinery and its control. Some other terms (differentiation, photomorphogenesis) are less directly connected, but the dominant signal points to transcription initiation/regulation by RNA Pol II.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051123","count":4},{"id":"GO:0043966","count":3},{"id":"GO:0006367","count":3},{"id":"GO:1900477","count":3},{"id":"GO:0070365","count":2}]},{"hash":"459988127521806147","title":"Innate Immune Response and Complement Activation","description":"This cluster is dominated by GO terms for defense against bacteria and classical complement activation, indicating an innate immune defense function as the core theme. A few nervous system development terms appear, likely due to annotation overlap or pleiotropy, but they do not define the main cluster function. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042742","count":15},{"id":"GO:0000187","count":13},{"id":"GO:0007399","count":11},{"id":"GO:0031175","count":10},{"id":"GO:0014068","count":10}]},{"hash":"439914502098253935","title":"Nucleolar ribosome biogenesis and rRNA processing","description":"The top GO terms cluster around nuclear/nucleolar roles in ribosome biogenesis and rRNA maturation (large subunit assembly, export, LSU/5.8S rRNA maturation, preribosome assembly) and DNA-templated transcription; a few outliers (apoptotic process, telomeric loop formation, lignin biosynthesis) may reflect incidental annotations, but the core signal is ribosome biogenesis in the nucleus.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0006334","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0000055","count":1},{"id":"GO:0000027","count":1}]},{"hash":"2160426743067450430","title":"Calcium-Dependent Signaling in Neural and Cardiac Tissues","description":"Many GO terms converge on calcium ion\u2013related signaling and downstream intracellular pathways (cellular response to calcium, release of sequestered calcium, intracellular signal transduction). Moreover, neural context terms (substantia nigra development, long-term synaptic potentiation) and cardiac context terms (regulation of SA node cell action potential) suggest a shared theme of calcium-mediated signaling governing excitability and plasticity in neural and heart tissues, with some broader involvement in apoptotic and developmental processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097284","count":4},{"id":"GO:2001015","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0060291","count":3}]},{"hash":"1009918008999361479","title":"Genome integrity and organellar gene expression","description":"The top GO terms cluster around organellar RNA processing (chloroplast and mitochondrial), mitochondrial ribosomal subunit assembly, and nuclear genome maintenance (DNA repair, telomere maintenance). This suggests a shared theme of maintaining genome expression and integrity across organelles and the nucleus, with some signaling and cell cycle terms appearing as peripheral context. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":2},{"id":"GO:1901259","count":2},{"id":"GO:0045333","count":2},{"id":"GO:0000963","count":2},{"id":"GO:1902775","count":2}]},{"hash":"560616612395409832","title":"Cell Adhesion and Receptor Signaling in Development","description":"The cluster\u2019s top GO terms cluster around cell adhesion (cell adhesion, substrate adhesion-dependent spreading), receptor-driven signaling (insulin receptor signaling, ephrin receptor signaling, positive regulation of peptidyl-tyrosine phosphorylation), and development/ECM-related processes (bone development, neural tube development, collagen fibril organization). This points to a group of proteins involved in adhesion-mediated signaling guiding developmental and extracellular matrix processes. Some terms like innate immune response and subtelomeric heterochromatin formation are less directly connected and may reflect broader, context-dependent roles. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0008286","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0060348","count":4},{"id":"GO:0006348","count":3},{"id":"GO:0021915","count":3}]},{"hash":"1304098500157174225","title":"RNA Processing and Translation Regulation","description":"The dominant GO terms point to RNA metabolism (RNA silencing by mRNA cleavage, mRNA stabilization, translation, and rRNA maturation) and ribosome biogenesis, suggesting a cluster of proteins tied to gene expression control; ancillary terms like SOS response and DNA repair reflect stress-related genome maintenance that can accompany RNA processing systems.","confidence":"Medium","size":19,"edges":10,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":3},{"id":"GO:0030423","count":3},{"id":"GO:0009047","count":3},{"id":"GO:0045433","count":3},{"id":"GO:0070934","count":3}]},{"hash":"2265273023891617803","title":"Organelle Protein Homeostasis and Trafficking","description":"The cluster\u2019s GO terms converge on protein handling within organelles (chaperone-assisted assembly, ER/Golgi retention, peroxisome import, autophagy-related turnover) and links to organelle energetics (oxidative phosphorylation/aerobic respiration). A stray signal for transcription elongation is present but does not override the dominant theme of protein quality control and subcellular localization.","confidence":"Medium","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051260","count":9},{"id":"GO:0072389","count":8},{"id":"GO:0051131","count":8},{"id":"GO:0016562","count":8},{"id":"GO:1903862","count":8}]},{"hash":"644909857584672882","title":"Organogenesis and tissue morphogenesis","description":"This cluster centers on developmental processes across multiple tissues, including lung morphogenesis with epithelial tube branching, basement membrane remodeling, and organ/tissue formation (e.g., intramembranous ossification, decidualization). Additional terms about neural precursor proliferation and hormonal responses (thyroid hormone) support a broad theme of organ development and morphogenesis, rather than a single tissue or pathway. The presence of some immune-related terms is incidental and does not redefine the core theme.","confidence":"High","size":19,"edges":101,"triangles":308,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0034769","count":16},{"id":"GO:0001957","count":16},{"id":"GO:0010815","count":16},{"id":"GO:2000179","count":16},{"id":"GO:0097067","count":16}]},{"hash":"1698191936335442692","title":"ER-Golgi Transport and Ciliogenesis","description":"The top GO terms cluster around ER-Golgi vesicle transport (retrograde and ER-to-Golgi), plus cilium assembly and neuron-related development, pointing to a module of proteins involved in intracellular trafficking that supports ciliogenesis and related neuronal processes. While other terms show broader cellular roles, the dominant theme is ER-Golgi transport linked to ciliogenesis.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006890","count":8},{"id":"GO:0051301","count":8},{"id":"GO:0006888","count":8},{"id":"GO:0031175","count":8},{"id":"GO:0060271","count":7}]},{"hash":"649219330219888399","title":"Nuclear transcription and ribosome biogenesis regulation","description":"This cluster is enriched for DNA-templated transcription and ribosome biogenesis, with signals of nucleolar protein localization and ubiquitin/ phosphorylation-mediated regulation, suggesting a coordinated nuclear gene-expression program tied to ribosome assembly and cell-cycle related processes.","confidence":"Medium","size":19,"edges":28,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":3},{"id":"GO:0043982","count":3},{"id":"GO:0043981","count":3},{"id":"GO:0007098","count":2},{"id":"GO:0007338","count":2}]},{"hash":"1642456587637242579","title":"Stress-responsive signaling and transcription regulators","description":"This cluster centers on proteins that regulate signaling pathways (Wnt, TGF-\u03b2, interferon) and transcription, with links to cell cycle control, neuron survival, and stress responses (hypoxia detection, respiration). The mix of regulatory GO terms suggests a cohesive set of factors coordinating cell fate decisions under stress, aided by chaperone-assisted assembly and telomerase-related processes rather than a single pathway.","confidence":"Medium","size":19,"edges":33,"triangles":18,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":4},{"id":"GO:0071157","count":3},{"id":"GO:0060334","count":3},{"id":"GO:0030511","count":3},{"id":"GO:0090263","count":3}]},{"hash":"1617834201212373229","title":"TGF-\u03b2 signaling and developmental transcription","description":"Most terms point to the TGF-\u03b2 pathway (SMAD complex assembly, TGF-\u03b2 receptor signaling) with downstream transcriptional activity (DNA-templated transcription, miRNA transcription regulation). Additional terms cover neural and developmental processes (synapse maturation, gastrulation, neuromast deposition, club cell differentiation, FSH secretion), suggesting a cluster of proteins involved in TGF-\u03b2\u2013mediated development and transcriptional regulation across tissues.","confidence":"High","size":19,"edges":97,"triangles":279,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007183","count":13},{"id":"GO:0007179","count":13},{"id":"GO:0006351","count":9},{"id":"GO:1902894","count":8},{"id":"GO:0060074","count":8}]},{"hash":"121775701848397899","title":"Neurodevelopment with transcription and ribosome biogenesis","description":"This cluster shows clear signals of nervous system development (neural tube closure, axonogenesis, pain perception) alongside core gene expression and protein synthesis processes (DNA-templated transcription, ribosome biogenesis). While other processes (DNA repair, cytokine regulation) are present, the combination suggests a cluster centered on neural development coupled with transcriptional and translational machinery. Overall, the theme is coherent but not exclusively neural, so a Medium confidence.","confidence":"Medium","size":19,"edges":3,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0001843","count":3},{"id":"GO:0006349","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0010951","count":2}]},{"hash":"1532616792277264281","title":"Nucleocytoplasmic transport and actin-based vesicle trafficking","description":"Based on the GO terms, the cluster is focused on movement and localization of molecules within the cell, especially nuclear import (NLS-bearing protein import, obsolete nuclear import) and mRNA transport, plus vesicle trafficking along actin filaments and related centrosome/vacuole inheritance processes. A few terms touch signaling or xenobiotic response, but the dominant theme is intracellular transport and localization machinery.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0051028","count":2},{"id":"GO:0000060","count":2}]},{"hash":"1678647960239530149","title":"Rho/Rac signaling and actin remodeling","description":"The cluster is dominated by GO terms for regulation of Rho and Rac GTPases, lamellipodium assembly, and actin cytoskeleton organization, i.e., actin dynamics and cell spreading driven by small GTPases. While insulin receptor signaling and heart development terms appear, the core theme is actin remodeling via Rho/Rac pathways.","confidence":"High","size":19,"edges":29,"triangles":3,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":13},{"id":"GO:0030032","count":12},{"id":"GO:0030036","count":12},{"id":"GO:0008286","count":12},{"id":"GO:1900026","count":12}]},{"hash":"183647454835452190","title":"Neuronal mitochondrial dynamics and mitophagy","description":"This cluster is dominated by terms on mitochondrial membrane organization, intracellular distribution of mitochondria, and type 2 mitophagy, together with neuronal functions such as adult locomotory behavior and regulation of synaptic vesicle recycling, suggesting a focus on mitochondrial maintenance in neurons. Although apoptosis and protein homooligomerization appear, the mitochondrial and synaptic themes are most prominent.","confidence":"High","size":19,"edges":36,"triangles":0,"max_degree":13,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0051260","count":10},{"id":"GO:0006915","count":7},{"id":"GO:0008344","count":6},{"id":"GO:0007006","count":6},{"id":"GO:0051301","count":6}]},{"hash":"1198634399844799507","title":"Inhibition of T/B cell receptor and MAPK signaling","description":"The cluster is dominated by GO terms for negative regulation of T cell receptor signaling, negative regulation of B cell receptor signaling, and negative regulation of the ERK/MAPK cascade, often via peptidyl-tyrosine dephosphorylation. This points to phosphatases and signaling inhibitors that dampen adaptive immune receptor signaling, with additional notes of ER stress (IRE1-mediated unfolded protein response) and regulation of B cell differentiation as broader context. ","confidence":"High","size":19,"edges":170,"triangles":952,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0050860","count":17},{"id":"GO:0000200","count":17},{"id":"GO:0070373","count":17},{"id":"GO:0035335","count":12},{"id":"GO:0050859","count":12}]},{"hash":"1867316912214313211","title":"Neural signaling and sensory perception","description":"The top GO terms cluster around brain-related processes: dopaminergic synaptic transmission, ERK/MAPK signaling, visual perception and learning, pain perception, and behavioral response to cocaine, all pointing to neuronal communication and sensory processing. Protein phosphorylation supports active signaling cascades typical of neural networks. A heart development term may reflect pleiotropy, but the dominant theme is neural signaling and perception.","confidence":"High","size":19,"edges":138,"triangles":513,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":12},{"id":"GO:0070374","count":11},{"id":"GO:0048148","count":11},{"id":"GO:0010759","count":11},{"id":"GO:0019233","count":11}]},{"hash":"349540153198500464","title":"Neuronal GPCR signaling and pain-related behavior","description":"The cluster is dominated by GO terms tied to nervous system signaling, notably sensory perception of pain, GPCR-mediated signaling with adenylyl cyclase activation, ERK cascade regulation, and behavioral responses to cocaine, suggesting a core theme of neuronal signaling and stimulus-driven behavior. Some developmental or metabolic terms appear, but the shared emphasis is on neural signaling and pain/behavioral responses.","confidence":"Medium","size":19,"edges":25,"triangles":5,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":15},{"id":"GO:0022900","count":14},{"id":"GO:0010579","count":14},{"id":"GO:0035025","count":14},{"id":"GO:0045777","count":14}]},{"hash":"1356500297348936164","title":"Adrenergic GPCR Signaling and Thermogenesis","description":"The dominant GO terms cluster around GPCR signaling that activates adenylate cyclase and modulates membrane potential, especially the adenylate cyclase-activating GPCR pathway and related cAMP signaling. Several terms tie to temperature-related physiology and metabolism, including cellular response to temperature stimulus and diet-induced thermogenesis, consistent with adrenergic signaling driving thermogenesis and energy metabolism. Some terms also touch on immune and tissue contexts (eosinophil degranulation, lung connective tissue development), but the core theme remains GPCR-cAMP signaling linked to temperature response and metabolic regulation. Confidence in this label is high.","confidence":"High","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":17},{"id":"GO:0042391","count":17},{"id":"GO:0019233","count":17},{"id":"GO:0045777","count":17},{"id":"GO:0022900","count":17}]},{"hash":"1371681561914350820","title":"Dopaminergic Synaptic Transmission and Cocaine Response","description":"The cluster highly centers on neural signaling, with strong enrichment for dopaminergic synaptic transmission, visual perception/learning, and a behavioral response to cocaine, alongside ERK pathway regulation. Although a few terms touch on unrelated processes, the dominant theme is dopamine-mediated neural signaling and drug-induced behavioral responses, justifying a label focused on dopaminergic transmission and cocaine-related behavior.","confidence":"High","size":19,"edges":164,"triangles":858,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":12},{"id":"GO:0070374","count":12},{"id":"GO:0048148","count":12},{"id":"GO:0010759","count":12},{"id":"GO:0019233","count":12}]},{"hash":"451962244375003049","title":"GPCR\u2013cAMP Signaling in Physiological Regulation","description":"Dominant GO terms point to activation of adenylate cyclase and GPCR-mediated signaling (GO:0007190; GO:0010579), indicating a core role for cAMP pathways in this cluster. Related processes such as positive regulation of blood pressure, regulation of membrane potential, thermogenesis, saliva secretion, and sensory functions (pain perception, temperature response) fit within a broader theme of systemic physiological control mediated by GPCR signaling. The inclusion of electron transport chain terms suggests metabolic context, but the recurring link to adenylate cyclase activation and GPCR pathways supports this label as a concise, representative name for the cluster.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":15},{"id":"GO:0045777","count":15},{"id":"GO:0022900","count":15},{"id":"GO:0010579","count":15},{"id":"GO:0042391","count":14}]},{"hash":"315102770396526334","title":"Neural development and signaling pathways","description":"The top GO terms cluster around nervous system development, axon guidance, and key developmental signaling pathways (Roundabout/Robo signaling, Hedgehog/SMO signaling, ERK cascade). This suggests proteins co-involved in neural patterning and broader developmental signaling. Some terms (heart development, defense responses) are less central, but the dominant theme is neural development linked to signaling networks.","confidence":"Medium","size":19,"edges":39,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0007286","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0035385","count":2}]},{"hash":"2239479164756904574","title":"Nuclear transcription, RNA processing, and cell cycle regulation","description":"The top GO terms cluster around nucleus-based processes: transcription initiation and termination, RNA splicing, and DNA replication, complemented by spindle assembly and cell cycle regulation. These suggest a shared theme of nuclear gene expression and cell cycle control, with a few outliers like fructose transport and viral genome replication that are less representative. Overall, the label reflects the central tendency of the functions.","confidence":"Medium","size":19,"edges":23,"triangles":0,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0006369","count":2},{"id":"GO:0006260","count":2},{"id":"GO:1904908","count":2}]},{"hash":"1200954291023265742","title":"N-terminal acetylation and chromatin regulation","description":"The top GO terms are dominated by acetylation processes (N-terminal acetylation of serine, glutamic acid, methionine, and spermidine acetylation) and chromatin-related functions (mitotic sister chromatid cohesion, subtelomeric heterochromatin formation), suggesting a theme of protein modification linked to chromatin dynamics. Some terms related to biosynthesis and developmental processes appear as outliers but do not override the acetylation-chromatin signal.","confidence":"Medium","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0017198","count":17},{"id":"GO:0018002","count":17},{"id":"GO:0032918","count":17},{"id":"GO:0043967","count":17},{"id":"GO:0017196","count":17}]},{"hash":"203934565491714617","title":"Neutrophil chemotaxis and GPCR signaling","description":"This cluster is driven by immune-related signaling, especially neutrophil recruitment and activation (chemotaxis and killing) and GPCR/cytoskeletal pathways (Rho, calcium, adenylyl cyclase signaling). It also includes related inflammatory regulation (TNF) and eosinophil degranulation, with tissue context in lung and vascular settings, suggesting a broader inflammatory/immune response oriented around neutrophil function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":12},{"id":"GO:0022900","count":12},{"id":"GO:0010579","count":12},{"id":"GO:0035025","count":12},{"id":"GO:0032720","count":11}]},{"hash":"137773186543651215","title":"Diverse cell differentiation and signaling","description":"The cluster\u2019s top GO terms center on differentiation of multiple cell types (cerebellar granule cells, fat cells, venous endothelial cells) with supporting signaling pathways (NOD2 signaling and NF-kappaB regulation) and sensory/pain-related terms, suggesting a broad theme of tissue-specific differentiation coupled with signaling processes rather than a single, narrow function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0032088","count":6},{"id":"GO:0021707","count":6},{"id":"GO:0061408","count":6},{"id":"GO:0010745","count":6},{"id":"GO:0045444","count":6}]},{"hash":"57233059691794154","title":"Immune Signaling and B Cell Activation","description":"This cluster is dominated by GO terms for PI3K/AKT signaling, defense against Gram-positive bacteria, B cell proliferation, and IgA isotype switching, pointing to immune activation and humoral response processes. While there are additional terms related to transcription regulation and development, the strongest shared signal centers on immune signaling and B cell\u2013mediated functions, suggesting a cohesive immune module. ","confidence":"Medium","size":19,"edges":11,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0043491","count":5},{"id":"GO:0045662","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0048298","count":5},{"id":"GO:0006355","count":5}]},{"hash":"543975077801645674","title":"Auditory Neuron Signaling and Ion Transport","description":"The top GO terms cluster around neuronal signaling and mechanosensory hearing: detection of mechanical stimulus in sound, transmission of nerve impulses, membrane depolarization, and excitatory postsynaptic potentials. Ion transmembrane transport (sodium and potassium) and paranodal junction assembly point to action potential propagation along auditory neurons, with plasticity signals like collateral sprouting supporting synaptic connectivity. This combination tightly links auditory mechanosensation to neuronal excitability and signal transmission.","confidence":"High","size":19,"edges":4,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":6},{"id":"GO:0019226","count":6},{"id":"GO:0030913","count":5},{"id":"GO:0035725","count":5},{"id":"GO:0071805","count":5}]},{"hash":"183090616385398290","title":"Neuronal cell adhesion and synapse assembly","description":"Based on the top GO terms, the cluster is enriched for heterophilic and homophilic cell-cell adhesion and for nervous system development and synapse assembly, pointing to a group of proteins involved in neuronal connectivity and synaptogenesis. While a few terms relate to bone, immunity, or macrophage regulation, the adhesion and synapse-related terms are most prominent.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":10},{"id":"GO:0007399","count":9},{"id":"GO:0007156","count":8},{"id":"GO:0051965","count":8},{"id":"GO:0006958","count":7}]},{"hash":"565515016409085126","title":"Adhesion-Mediated Immune Regulation and Phagocytosis","description":"The Top Terms cluster around heterophilic cell-cell adhesion and regulation of innate and adaptive immune cell activities (NK, macrophages, cytotoxic T cells), along with actin cytoskeleton remodeling driven by cell adhesion, synapse assembly, and processes like phagocytosis and host-cell entry. These together suggest a module where cell adhesion interfaces coordinate immune signaling and endocytic processes, with some notes on adhesion in specialized tissues (e.g., AV node). ","confidence":"Medium","size":19,"edges":142,"triangles":571,"max_degree":18,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":9},{"id":"GO:0002859","count":8},{"id":"GO:0043031","count":8},{"id":"GO:0043318","count":8},{"id":"GO:0090138","count":8}]},{"hash":"1850415202985296135","title":"Rho GTPase signaling and vesicle trafficking","description":"The top GO terms cluster around regulation of Rho GTPase signaling and GTPase activity, paired with intracellular transport processes (endosome-to-lysosome, intracellular transport) and vesicle exocytosis, plus phosphatidylinositol signaling. These points together to a coherent theme of membrane-associated signaling that governs vesicle trafficking and cytoskeletal regulation; a few terms like heart development and mitotic cell cycle may reflect broader roles but do not dominate the theme.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0008333","count":3},{"id":"GO:0006886","count":3},{"id":"GO:2000300","count":3}]},{"hash":"1198642685481055530","title":"GPCR-cAMP Signaling and Metabolic Regulation","description":"The top GO terms are dominated by activation of adenylate cyclase and GPCR signaling, pointing to cAMP-mediated signaling as the central theme. Additional terms indicate metabolic and physiological processes linked to energy production (electron transport chain, thermogenesis) and systemic regulation (blood pressure, Rho signaling). Some retina-related terms likely reflect tissue-specific roles of this signaling axis, but overall the cluster appears to represent GPCR-driven cAMP signaling coordinating metabolic and physiological responses.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":12},{"id":"GO:0045777","count":12},{"id":"GO:0022900","count":12},{"id":"GO:0010579","count":12},{"id":"GO:0035025","count":12}]},{"hash":"677299295271604367","title":"Extracellular matrix remodeling and immune defense","description":"This cluster is dominated by GO terms for extracellular matrix disassembly, tissue remodeling, biomineral tissue development, and immune-related defense (complement activation, responses to LPS and fungus), suggesting a cohesive theme around ECM dynamics linked to host defense and coagulation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0030194","count":7},{"id":"GO:0031214","count":7},{"id":"GO:0032496","count":6},{"id":"GO:0030901","count":6}]},{"hash":"414666270498178947","title":"Cochlear glutamatergic synaptic transmission","description":"The terms point to auditory biology, including sensory perception of sound and inner ear development, and emphasize glutamatergic synaptic signaling with associated depolarization and excitatory postsynaptic potentials, consistent with cochlear hair cell synapses. The presence of ion transport and cell adhesion terms also supports synapse formation and function in the inner ear.","confidence":"High","size":19,"edges":103,"triangles":211,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":12},{"id":"GO:0007626","count":12},{"id":"GO:0035725","count":9},{"id":"GO:0071805","count":9},{"id":"GO:0060079","count":9}]},{"hash":"200244108757726142","title":"Ubiquitin-Dependent Proteolysis and Innate Immunity","description":"This cluster is dominated by ubiquitin pathways (ubiquitin-dependent protein catabolic process and protein polyubiquitination) and includes apoptosis regulation, innate immune responses, and defense against virus, plus cell-cycle regulation. This pattern points to a theme where ubiquitin-mediated protein turnover coordinates cell fate with antiviral defense. The absence of edges does not negate a shared function, as proteins can participate in multiple ubiquitin-related pathways and immune signaling.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0000209","count":11},{"id":"GO:0070512","count":8},{"id":"GO:0042981","count":8},{"id":"GO:0043066","count":8}]},{"hash":"1143489148834924180","title":"Developmental Signaling in Heart and Immune Systems","description":"This cluster shows a mix of terms tied to development (heart development, hemopoiesis) and signaling pathways (Rho regulation, PI3K/AKT signaling, IL-7 response), plus immune-related differentiation (NK T cell differentiation). The common thread is how signaling cascades guide development and immune cell processes, with a few terms that are peripheral (sensory perception). Overall, a label emphasizing developmental signaling in cardiac and immune contexts captures the core theme.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007507","count":7},{"id":"GO:0035023","count":7},{"id":"GO:0043552","count":6},{"id":"GO:0007605","count":5},{"id":"GO:0098761","count":5}]},{"hash":"469504886969226497","title":"Ubiquitin-dependent proteolysis and NF-kappaB signaling","description":"This cluster centers on ubiquitin-mediated protein degradation (ubiquitin-dependent proteolysis, autoubiquitination, ERAD, histone catabolic processes, K6-linked ubiquitination) and on regulation of inflammatory signaling pathways (TNF/NF-kappaB signaling, NF-kappaB-inducing kinase activation, I-kappaB phosphorylation). The shared theme is proteasome-mediated turnover coupled with modulation of NF-kappaB signaling.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0051865","count":11},{"id":"GO:1903265","count":11},{"id":"GO:0036205","count":10},{"id":"GO:0007250","count":10}]},{"hash":"1904972639329013606","title":"Organ Development and Innate Immune Signaling","description":"This cluster centers on developmental processes for multiple organs (heart, retina, lung connective tissue) and concurrent innate immune activities (eosinophil and neutrophil functions, dendritic cell chemotaxis, LPS response), suggesting proteins involved in both tissue development and innate immune signaling pathways.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":19},{"id":"GO:0060427","count":19},{"id":"GO:0070963","count":19},{"id":"GO:0051482","count":19},{"id":"GO:0060041","count":19}]},{"hash":"2181615985000693691","title":"Unknown","description":"The terms span metabolism (electron transport chain), broad signaling (GPCR pathways, Rho signaling), immune-related processes (eosinophil/neutrophil activities), and various tissue development/regulatory roles (lung, retina, endothelial barrier), with no clear, single shared function linking the cluster. This diversity makes a cohesive cluster label unlikely. ","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":18},{"id":"GO:0010579","count":18},{"id":"GO:0035025","count":18},{"id":"GO:0045777","count":18},{"id":"GO:0043311","count":17}]},{"hash":"110704901464136606","title":"GPCR\u2013Rho Signaling in Heart and Muscle","description":"The terms cluster around regulation of GTPase activity and Rho signaling, with clear connections to heart development and regulation of muscle contraction. Additional GO terms point to GPCR-mediated pathways (tachykinin, thrombin) and even neural-related synaptic vesicle dynamics, together suggesting a cohesive signaling module influencing cardiac and skeletal muscle function and related cellular processes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0007507","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0008344","count":4},{"id":"GO:0016185","count":4}]},{"hash":"2173561515617488701","title":"Neurodevelopmental and cytoskeletal proteins","description":"The top GO terms are dominated by neural development and differentiation (spinal cord development, neuron projection development, lens fiber cell differentiation, multicellular organism development) and cytoskeleton-related processes (microtubule-based movement), with DNA-templated transcription also pointing to developmental regulation. A single Fc-epsilon receptor signaling term appears but seems peripheral to the main theme, suggesting the cluster centers on neural development and cytoskeletal transport rather than immune signaling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038095","count":3},{"id":"GO:0042102","count":3},{"id":"GO:0010765","count":3},{"id":"GO:0021510","count":2},{"id":"GO:0031175","count":2}]},{"hash":"589970848609069571","title":"Immune Regulation and Leukocyte Signaling","description":"The top GO terms cluster around immune cell signaling and regulation, including Fc-epsilon receptor signaling, neutrophil extravasation, NK cell and macrophage activity regulation, IL-10 production, gamma-delta T cell activation, and negative regulation of TLR signaling. This pattern indicates a coherent theme of immune communication and control across leukocytes, with a few outliers like spermatid development. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038095","count":3},{"id":"GO:0072672","count":2},{"id":"GO:0002859","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0043031","count":2}]},{"hash":"1643038452218256501","title":"Cardiovascular-Immune Signaling","description":"Top GO terms cluster around heart development, blood coagulation, blood pressure regulation, monocyte chemotaxis, and defense against bacteria, with supporting ERK signaling. Together these suggest a cardiovascular-immune regulatory theme, complemented by stress/xenobiotic and metabolic context terms. The lack of edges implies a broad set of related roles across tissues rather than a single tight module.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":14},{"id":"GO:0070374","count":14},{"id":"GO:0007596","count":14},{"id":"GO:0042493","count":14},{"id":"GO:0019233","count":14}]},{"hash":"731531361495672166","title":"Cardiac muscle development and conduction system","description":"Most top GO terms are about heart and muscle development (left ventricular cardiac muscle tissue morphogenesis, regulation of AV/SA node action potentials, and smooth muscle differentiation), with a secondary signal of general muscle differentiation (myotube regulation). Although a few terms (tRNA processing, kidney development, amyloid-beta regulation) are less connected, the dominant theme points to cardiac muscle development and differentiation, so the label should reflect that theme.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010832","count":3},{"id":"GO:0051152","count":2},{"id":"GO:0008033","count":2},{"id":"GO:1902430","count":2},{"id":"GO:0001822","count":2}]},{"hash":"1818068012061372261","title":"Placental and embryonic development","description":"The top GO terms cluster around placental differentiation (trophoblast giant cells) and embryonic development ( EMT in heart formation, left-right patterning) with additional organogenesis terms (cartilage, endocrine system), indicating a cohesive focus on early development and placenta formation; minor RNA processing terms are present but not defining.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0060707","count":17},{"id":"GO:0003198","count":17},{"id":"GO:0060536","count":17},{"id":"GO:0060806","count":17},{"id":"GO:0035270","count":17}]},{"hash":"1956548880558710944","title":"Unknown","description":"The terms span innate immunity, membrane repair, synapse formation/plasticity, development, lipid catabolism, and cell division, showing no single cohesive function tying the proteins together; with no edges, a specific label is not justifiable.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036089","count":2},{"id":"GO:0097050","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0001778","count":2},{"id":"GO:0051092","count":2}]},{"hash":"1142757451549676318","title":"Plant cell wall biosynthesis and protein glycosylation","description":"The cluster is strongly enriched for plant-specific processes related to cell wall formation and organization (plant-type secondary cell wall biogenesis, cell wall organization) and protein glycosylation (O-linked glycosylation via mannose and via N-acetyl-galactosamine), with supporting signals from related processes like mucilage biosynthesis. Some unrelated terms appear, but the dominant theme points to plant cell wall biosynthesis and glycoprotein modification.","confidence":"High","size":18,"edges":140,"triangles":638,"max_degree":17,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0005978","count":5},{"id":"GO:0051123","count":3},{"id":"GO:0043966","count":3},{"id":"GO:0006012","count":3},{"id":"GO:0043403","count":3}]},{"hash":"1504791512600407925","title":"Ribosome and Translation Machinery","description":"The top GO terms are dominated by translation and ribosome biogenesis (translation, cytoplasmic translation, ribosome biogenesis). While there are some developmental or stress-related annotations, the strongest signal points to protein synthesis machinery, suggesting the cluster groups ribosomal components or translation factors.","confidence":"High","size":18,"edges":28,"triangles":9,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0042254","count":3},{"id":"GO:0046677","count":2},{"id":"GO:0002244","count":2},{"id":"GO:0002181","count":2}]},{"hash":"2064249623161753323","title":"Mitosis and apoptosis with ubiquitin regulation","description":"This cluster features GO terms tied to cell division (mitotic spindle assembly, mitotic cell cycle) and apoptosis (cytochrome c release, apoptotic chromosome condensation), along with protein turnover via ubiquitination. The co-occurrence suggests a functional group of proteins that coordinate cell-cycle progression with programmed cell death and proteolysis, with a modulation layer via ubiquitin signaling; transcriptional and Wnt-related terms appear but are secondary. Therefore, a label focusing on mitosis/apoptosis and ubiquitin regulation captures the core theme.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0030263","count":2},{"id":"GO:0090200","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0042176","count":2}]},{"hash":"1179841105138466927","title":"Actin Cytoskeleton Remodeling and Adhesion","description":"The most represented GO terms center on actin cytoskeleton dynamics and cell\u2013substrate adhesion: lamellipodium assembly, stress fiber formation, Rho signaling, and integrin-mediated adhesion. The presence of cortical microtubule organization and actin cytoskeleton reorganization supports a module regulating cytoskeletal architecture, with additional signals like phagolysosome assembly and growth hormone receptor signaling indicating broader signaling crosstalk that modulates these processes.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0071320","count":11},{"id":"GO:0033628","count":11},{"id":"GO:0008285","count":11},{"id":"GO:0035023","count":11},{"id":"GO:0010592","count":10}]},{"hash":"2187439720686431831","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0000472","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0042273","count":3}]},{"hash":"1995428758058255816","title":"Membrane trafficking and immune signaling","description":"The proteins show enrichment for GO terms centered on membrane transport, vesicle trafficking, membrane repair, and exocytosis, alongside immune and immune-regulatory processes (innate immunity, neutrophil degranulation, extravasation regulation). This suggests a cohesive role in membrane-associated secretion and signaling across immune and reproductive contexts, rather than a single narrow pathway.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035435","count":3},{"id":"GO:0044381","count":3},{"id":"GO:1904659","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0001778","count":3}]},{"hash":"574581509516208284","title":"Mitochondrial translation and tRNA charging; telomere maintenance","description":"The cluster prominently features GO terms for translation and multiple tRNA aminoacylation activities, especially mitochondrial lysyl- and aspartyl-tRNA charging, indicating a role in mitochondrial protein synthesis. Additional telomere-related terms (telomere capping, maintenance) suggest a broader link to genome stability. Together, these signals point to a theme around protein synthesis machinery with a mitochondrial emphasis, complemented by telomere maintenance processes.","confidence":"Medium","size":18,"edges":28,"triangles":14,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071915","count":6},{"id":"GO:0006412","count":6},{"id":"GO:0070200","count":6},{"id":"GO:0070146","count":6},{"id":"GO:0006430","count":6}]},{"hash":"1838098953855027659","title":"Cytotoxic Immune Regulation and Antigen Presentation","description":"This cluster is dominated by GO terms related to regulation of cytotoxic lymphocyte activity (NK and CTL), antibody-dependent cellular cytotoxicity, and antigen processing/presentation via MHC class I, plus inflammatory hypersensitivity and wound healing modulation. These themes point to coordinated control of cytotoxic immune responses and antigen presentation pathways, including ADCC and modulation of degranulation, consistent with a cohesive immune-regulatory cluster.","confidence":"High","size":18,"edges":83,"triangles":260,"max_degree":17,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002859","count":17},{"id":"GO:0090138","count":17},{"id":"GO:0043318","count":17},{"id":"GO:0001788","count":16},{"id":"GO:0042590","count":16}]},{"hash":"2240503570614095418","title":"Actin cytoskeleton remodeling and endocytosis","description":"The cluster is dominated by GO terms related to actin dynamics (actin nucleation, cortical actin organization, GTPase activity regulation) and membrane trafficking (clathrin-dependent endocytosis), with supporting terms about centrosome/microtubule localization. This points to a cohesive theme of actin cytoskeleton remodeling coupled with vesicle trafficking. ","confidence":"High","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2000251","count":4},{"id":"GO:0060292","count":4},{"id":"GO:0000082","count":4},{"id":"GO:0097011","count":4},{"id":"GO:0043547","count":4}]},{"hash":"970535979014693233","title":"Developmental differentiation and embryogenesis","description":"This cluster shows enrichment for developmental and differentiation processes across systems: germline and egg chamber development in insects, embryonic events like syncytial nuclear migration and cell-cycle regulation, and differentiation of hematopoietic lineages, along with general transcriptional regulation. The variety suggests a broad role in coordinating developmental programs rather than a single specific pathway, and the absence of edges implies functional diversity among the proteins. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030708","count":8},{"id":"GO:0030713","count":8},{"id":"GO:0030851","count":7},{"id":"GO:0048706","count":7},{"id":"GO:0035190","count":7}]},{"hash":"871419674045027517","title":"Splicing Regulation and mRNA Processing","description":"The top GO terms cluster around spliceosome-mediated RNA processing, including regulation of alternative splicing, mRNA splicing via the spliceosome, mRNA export, and mRNA stability under stress. This suggests a cohesive group of proteins involved in RNA maturation and quality control, especially under stress conditions.","confidence":"High","size":18,"edges":7,"triangles":1,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":5},{"id":"GO:0010610","count":5},{"id":"GO:0000381","count":5},{"id":"GO:0048026","count":5},{"id":"GO:0031047","count":5}]},{"hash":"377787416087617797","title":"Developmental cell cycle and DNA replication","description":"This cluster is dominated by GO terms centered on the centrosome cycle, DNA replication, and positive regulation of nuclear cell cycle DNA replication, indicating a core role in cell division during development. Additional terms related to embryonic cranial skeleton morphogenesis and CNS neuron development support a developmental context, while caveolin-mediated endocytosis and cytosine metabolism appear as ancillary processes, suggesting some pleiotropy but not changing the primary theme.","confidence":"High","size":18,"edges":42,"triangles":44,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007098","count":18},{"id":"GO:0006260","count":18},{"id":"GO:0048701","count":18},{"id":"GO:0010571","count":18},{"id":"GO:0072584","count":17}]},{"hash":"1599249758259083746","title":"Chromosome segregation and chromatin organization","description":"Most terms converge on chromatin targeting and chromosome dynamics (localization to chromatin; nuclear pore assembly; chromatid cohesion/separation), pointing to a chromosome maintenance/nuclear transport theme. A few terms (innate immune response, defense against virus, bone development) appear as outliers.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0045087","count":5},{"id":"GO:0051901","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0071169","count":4}]},{"hash":"754603100957099282","title":"mRNA processing and export regulation","description":"The top terms center on spliceosome-mediated splicing, polyadenylation, mRNA stability, and nuclear export, indicating a cluster of proteins involved in post-transcriptional mRNA maturation and trafficking.","confidence":"High","size":18,"edges":129,"triangles":508,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":12},{"id":"GO:0048026","count":10},{"id":"GO:0031047","count":10},{"id":"GO:1901407","count":10},{"id":"GO:0010610","count":8}]},{"hash":"2031226512256720425","title":"Membrane Transporters for Nutrients and Xenobiotics","description":"The cluster is dominated by diverse transmembrane transport GO terms\u2014phosphate, vitamin, xenobiotic, heme, potassium, nitrate, and xylose transport\u2014along with related cellular response to sugar stimulus. This points to a group of membrane transporter proteins with broad substrate specificity rather than a single substrate, justifying a transporter-focused label.","confidence":"High","size":18,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0035435","count":11},{"id":"GO:0035461","count":9},{"id":"GO:0006855","count":9},{"id":"GO:0015886","count":8},{"id":"GO:0042891","count":7}]},{"hash":"759741180010232370","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":145,"triangles":697,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":12},{"id":"GO:0031047","count":12},{"id":"GO:0071051","count":9},{"id":"GO:0000467","count":9},{"id":"GO:0000398","count":9}]},{"hash":"2018628998958472680","title":"Neural development and signaling","description":"This cluster combines neural development indicators (cerebellar cortex formation, Bergmann glial differentiation, regulation of axon regeneration) with broad signal transduction elements (insulin receptor signaling, T cell receptor signaling, tyrosine dephosphorylation, CDK activity regulation). The neural development terms provide a cohesive core, while the signaling and phosphorylation terms suggest shared regulatory mechanisms operating during development. A few cell-cycle related terms appear, but the dominant theme appears to be neural development linked with signaling control.","confidence":"Medium","size":18,"edges":129,"triangles":496,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034501","count":10},{"id":"GO:0045736","count":10},{"id":"GO:0008286","count":10},{"id":"GO:0021697","count":10},{"id":"GO:0060020","count":10}]},{"hash":"2272939975863358890","title":"Nuclear RNA processing and chromatin modification","description":"The top terms are dominated by nuclear processes tied to gene expression: mRNA splicing via spliceosome and rRNA maturation indicate RNA processing, while DNA-templated transcription and histone modifications (acetylation/methylation) point to chromatin-level regulation of transcription. This combination suggests a cluster of proteins involved in regulating transcription and RNA processing within the nucleus, rather than cytoplasmic signaling or metabolism.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0051567","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0043982","count":3},{"id":"GO:0043966","count":3}]},{"hash":"87516711623420540","title":"B cell activation and antigen presentation","description":"This cluster centers on B cell signaling and activation (B cell receptor signaling, positive regulation of B cell activation) and antigen processing/presentation via MHC class Ib, coupled with phagocytosis-related terms and complement activation. Together, these terms point to a coordinated adaptive immune response where B cells become activated, process antigens, and present lipid antigens, with supporting innate processes like phagocytosis and complement activity.","confidence":"High","size":18,"edges":67,"triangles":10,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":8},{"id":"GO:0050853","count":8},{"id":"GO:0006958","count":8},{"id":"GO:0006911","count":8},{"id":"GO:0050871","count":8}]},{"hash":"1136223374471826323","title":"Neuronal development and differentiation","description":"The top GO terms cluster around neural fate specification across the CNS (spinal cord motor neuron and oligodendrocyte differentiation, interneuron differentiation, subpallium neuron fate, amacrine cell differentiation, GABAergic interneuron differentiation) along with transcription by RNA polymerase II, suggesting a set of proteins involved in neural development and neuronal differentiation. A few non-neural development terms (pancreas, lung) appear but are less dominant, likely reflecting shared regulatory factors. Overall, a neural development-focused cluster is most representative.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":15},{"id":"GO:0021530","count":8},{"id":"GO:0021520","count":8},{"id":"GO:0031018","count":8},{"id":"GO:0021892","count":8}]},{"hash":"1457004677747180444","title":"Clathrin-mediated endocytosis and GPCR trafficking","description":"This cluster is dominated by GO terms related to membrane trafficking and signaling regulation: clathrin-dependent endocytosis, GPCR internalization, and regulation of GTPase activity, with ubiquitination as a coordinating post-translational control. While there are additional terms tied to mitochondria and development that are less represented, the core theme centers on receptor endocytosis and modulation of signaling pathways through trafficking and ubiquitin-mediated regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032925","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0072583","count":3},{"id":"GO:0002031","count":3},{"id":"GO:0016567","count":3}]},{"hash":"1460597274292364388","title":"Neuronal actin remodeling and endocytosis","description":"The cluster shows strong signals for actin-driven protrusion assembly (lamellipodium/filopodium), endocytic processes (clathrin-dependent endocytosis, GPCR internalization), and neuronal synaptic activity (GABAergic transmission), suggesting a shared theme of actin dynamics coordinating vesicle recycling in neurons. ","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0051489","count":3},{"id":"GO:0046847","count":3},{"id":"GO:1900026","count":3}]},{"hash":"2126692734361742552","title":"Immune cell chemotaxis and adhesion signaling","description":"This cluster centers on leukocyte movement and adhesion, with multiple terms for T cell and lymphocyte chemotaxis, eosinophil migration, and integrin-mediated cell\u2013cell adhesion. It also includes inflammatory signaling (TNF response) and pathways like PKC signaling and VEGF that modulate leukocyte recruitment and vascular interactions. An outlier fertilization term is present but does not override the overall immune-migration/adhesion theme.","confidence":"High","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051088","count":4},{"id":"GO:0035625","count":4},{"id":"GO:0070528","count":4},{"id":"GO:0007338","count":4},{"id":"GO:2000418","count":4}]},{"hash":"41193449100685120","title":"Glycolysis and glycogen catabolism","description":"This cluster is dominated by GO terms for glycolysis and breakdown of glycogen and storage polysaccharides (canonical glycolysis, fructose-6-phosphate metabolism, glycogen catabolic process). Together they indicate a cohesive role in carbohydrate energy metabolism. A few outliers (S-methylmethionine cycle, betaine catabolic processes) exist but do not define the core function.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":5},{"id":"GO:0006002","count":4},{"id":"GO:0005980","count":4},{"id":"GO:0093001","count":4},{"id":"GO:0061621","count":4}]},{"hash":"1286368728187126432","title":"Ubiquitin-Dependent Immune and Circadian Regulation","description":"This cluster centers on ubiquitin-mediated protein catabolism and ubiquitination, with overlapping themes in innate antiviral defense, circadian rhythm regulation, and vitamin D response. The combination suggests a group of proteins involved in post-translational regulation that impacts immune signaling and daily physiological timing, rather than a single tightly connected pathway, which aligns with the diverse GO terms observed.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0042752","count":5},{"id":"GO:0051260","count":5},{"id":"GO:0051607","count":5},{"id":"GO:0045087","count":5}]},{"hash":"751847740035744534","title":"Embryonic Morphogenesis and Transcriptional Repression","description":"This cluster features terms tied to embryonic development across multiple lineages (palatal roof development, endocardial cushion EMT, left-right patterning, cartilage morphogenesis, placental/trophoblast differentiation, endocrine system development, and pancreatic cell development). The common theme is embryonic organogenesis and tissue morphogenesis, with an additional emphasis on transcriptional regulation, notably negative regulation of RNA polymerase II activity. This combination supports a cohesive interpretation of the cluster\u2019s function as developmental morphogenesis coordinated with transcriptional repression.","confidence":"High","size":18,"edges":11,"triangles":0,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0060021","count":9},{"id":"GO:0003198","count":9},{"id":"GO:0060707","count":9},{"id":"GO:0060536","count":9}]},{"hash":"620462839283846425","title":"Unknown","description":"The top GO terms are highly diverse, covering synaptic vesicle recycling, cytoskeletal regulation, immune signaling, GTPase activation, various metabolic processes (glycogen and glucose regulation, fatty acid beta-oxidation), and embryonic placental development. There is no clear, unifying biological function connecting these terms across the proteins, so a coherent, specific label cannot be assigned.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:1903423","count":16},{"id":"GO:0051489","count":16},{"id":"GO:0098761","count":16},{"id":"GO:0090630","count":16},{"id":"GO:0032094","count":16}]},{"hash":"1359883100033865475","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"This cluster is dominated by terms related to actin dynamics, lamellipodium and filament bundle assembly, and cell migration, pointing to a core theme of actin cytoskeleton remodeling driving cell movement. Additional terms like epithelial polarity and Wnt signaling align with development and tissue organization often linked to cytoskeletal changes, supporting the overall interpretation.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":4},{"id":"GO:0051017","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0021707","count":3},{"id":"GO:0090162","count":3}]},{"hash":"1206689351017987574","title":"Immune signaling and cytoskeletal dynamics","description":"GO terms emphasize immune signaling (B cell receptor signaling, dendritic cell differentiation) and actin cytoskeleton regulation (filopodium assembly, Rho signaling), with hematopoietic development (megakaryocytes), suggesting proteins that coordinate immune signaling with cytoskeletal dynamics.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043552","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0061000","count":4}]},{"hash":"1479836312413777830","title":"Endocytic trafficking and innate immune signaling","description":"The top GO terms cluster around endocytosis and receptor-mediated signaling\u2014clathrin-dependent endocytosis, endosome organization, and regulation of receptor-mediated endocytosis\u2014along with innate immune signaling such as positive regulation of TLR4 signaling and defense responses. While some terms touch on development or sensory/muscle functions, the dominant theme is proteins involved in endocytic trafficking and associated immune signaling.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":3},{"id":"GO:0072583","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0007032","count":3},{"id":"GO:0035023","count":3}]},{"hash":"1781569059468877779","title":"Mitochondrial Transport and Energy Regulation","description":"The top GO terms describe transport of ADP/ATP, phosphate, iron, and magnesium across the mitochondrial membranes, along with mitochondrial membrane potential regulation and fission. These together highlight mitochondrial energy metabolism and dynamics. Additional terms about cellular responses to insulin, glucose, and amino acid starvation point to signaling that tunes mitochondrial function in response to nutrient status. Taken together, the cluster appears to represent mitochondrial energy transport and regulatory processes.","confidence":"High","size":18,"edges":18,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0048250","count":13},{"id":"GO:0035435","count":13},{"id":"GO:0015866","count":13},{"id":"GO:0090149","count":13},{"id":"GO:0051881","count":13}]},{"hash":"1067274997607690907","title":"Unknown","description":"The terms are highly heterogeneous, covering vacuolar ATPase assembly, mitochondrial ribosome assembly, metabolism, development, differentiation, tRNA modification, transsulfuration, mitosis, and dephosphorylation, with no dominant shared pathway or clear interconnections among the proteins. There is no cohesive functional theme or interaction pattern to define a meaningful label, so Unknown is appropriate.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070072","count":2},{"id":"GO:0061668","count":1},{"id":"GO:0006067","count":1},{"id":"GO:0021510","count":1},{"id":"GO:0030855","count":1}]},{"hash":"21128192334653722","title":"Unknown","description":"The top GO terms span skin differentiation, visual perception, neural development, immune signaling, and general cellular processes with no single cohesive function tying the proteins together, and there are no edges connecting members to form a functional module. Therefore, the cluster cannot be confidently named by a unifying theme.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030216","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0043113","count":4},{"id":"GO:0032298","count":3},{"id":"GO:0042535","count":3}]},{"hash":"1659158310163764680","title":"Unknown","description":"Explanation: The top GO terms span both innate immune functions (eosinophil degranulation, neutrophil killing of Gram-negative bacteria, dendritic cell chemotaxis, response to lipopolysaccharide) and various tissue development processes (lung connective tissue, retina, heart) plus endothelial regulation, with no single unifying theme. Consequently, there isn\u2019t a coherent functional label that accurately represents all proteins in this cluster.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":18},{"id":"GO:0060427","count":18},{"id":"GO:0070963","count":18},{"id":"GO:0051482","count":18},{"id":"GO:0060041","count":18}]},{"hash":"1093684980731579073","title":"Taste and phototaxis neural signaling","description":"The cluster groups proteins involved in neuronal signaling and sensory perception, including GABA signaling, ion transport (Na+/K+), excitatory postsynaptic potentials, taste perception (sweet), phototaxis, and locomotion. These together suggest neural circuits that process sensory inputs (taste and light) and drive movement; a defensive response term may be incidental noise. ","confidence":"High","size":18,"edges":20,"triangles":21,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0000187","count":17},{"id":"GO:0007214","count":17},{"id":"GO:0035725","count":17},{"id":"GO:0042742","count":17},{"id":"GO:0001661","count":17}]},{"hash":"716583102803646401","title":"Neural development and morphogenesis","description":"This cluster's top GO terms center on neuron development (neuron migration, differentiation, synapse maturation) and morphogenesis (tube formation, cardiac atrium morphogenesis, blood vessel remodeling). Other terms about cell polarity and Rac signaling support coordinated cytoskeletal rearrangements essential for neural and tissue development. Together they point to a developmental program with emphasis on nervous system maturation and tissue morphogenesis.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030010","count":3},{"id":"GO:0035148","count":3},{"id":"GO:0007098","count":3},{"id":"GO:0001764","count":3},{"id":"GO:0035022","count":3}]},{"hash":"288142673351918361","title":"Neuroimmune development and inflammation","description":"This cluster combines neural-development keywords (positive regulation of synapse assembly, axonal fasciculation, myelination) with innate-immune and inflammatory terms (innate immune response, defense response to Gram-positive bacteria, positive regulation of inflammatory response). The overlap suggests proteins involved in neuroimmune signaling or coordinated neural development with immune modulation, rather than a single, narrow function. Some terms about otolith morphogenesis and lung connective tissue development indicate broader developmental roles, but the core theme appears to center on neural formation coupled with immune activity.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0050830","count":4},{"id":"GO:0051965","count":4},{"id":"GO:0032474","count":3},{"id":"GO:0014068","count":3}]},{"hash":"1354192504890137525","title":"Developmental transcriptional regulation and signaling","description":"The top GO terms point to transcriptional control (DNA-templated transcription, regulation, RNA polymerase II repression) coupled with developmental processes (adult muscle development, dendrite development, Wnt signaling regulation) and related signaling pathways (MyD88-dependent TLR4 signaling). This pattern suggests a cluster of proteins involved in coordinating development and differentiation through transcriptional regulation and signaling, rather than a single, narrow pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035660","count":3},{"id":"GO:0007527","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0030111","count":2},{"id":"GO:0007605","count":2}]},{"hash":"1148948176115259716","title":"Adhesion signaling and development regulation","description":"The cluster centers on adhesion-related processes, highlighted by integrin activation and focal adhesion assembly, suggesting a role in cell-ECM signaling. Developmental terms like dendrite development and left/right pattern formation indicate broader developmental regulation, with fat cell differentiation reinforcing the differentiation theme. While some items reflect general regulatory processes (negative regulation of transcription/transport), the cohesive theme appears to be regulation of adhesion signaling within developmental contexts.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":2},{"id":"GO:1903026","count":2},{"id":"GO:2000352","count":2},{"id":"GO:0032410","count":2},{"id":"GO:0034763","count":2}]},{"hash":"661419513333143783","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning cell wall organization, teichoic acid and hyaluronan biosynthesis, L-arabinose metabolism, and glycosylation, alongside immune-related processes (immunoglobulin production, MHC class II biosynthetic regulation) and host-virus interaction (host-mediated activation of viral genome replication). This lack of a clear, single functional theme suggests no coherent cluster label can be confidently assigned.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":3},{"id":"GO:0044829","count":2},{"id":"GO:1904780","count":2},{"id":"GO:0045347","count":2},{"id":"GO:0000289","count":2}]},{"hash":"1393992691423891244","title":"Embryonic Morphogenesis and Patterning","description":"The proteins map to diverse developmental processes across embryogenesis: cartilage and hair follicle morphogenesis, left/right patterning, placental/endocrine development, pancreatic cell formation, mesoderm formation, and EMT in heart-associated structures. Together these terms suggest a broad developmental and morphogenetic program rather than a single pathway, hence this label.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":18},{"id":"GO:0060972","count":18},{"id":"GO:0060806","count":18},{"id":"GO:0031069","count":18},{"id":"GO:0060021","count":18}]},{"hash":"1972593138602529646","title":"Embryonic Morphogenesis and Differentiation","description":"The top GO terms cluster around embryonic development, tissue morphogenesis, and lineage differentiation across multiple organs (cartilage, left/right patterning, placenta, hair follicles, roof of the mouth, endocrine and pancreatic development, EMT in heart structures, mesoderm development), indicating a coherent theme of embryogenesis-related processes.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":17},{"id":"GO:0060972","count":17},{"id":"GO:0060806","count":17},{"id":"GO:0031069","count":17},{"id":"GO:0060021","count":17}]},{"hash":"1607567133067716877","title":"Unknown","description":"The terms are scattered across lipid biosynthesis, eye/brain development, cytoskeleton, and various biosynthetic processes, with no single dominant function tying the proteins together. There isn\u2019t a clear, cohesive theme to label the cluster with a precise, representative function.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010025","count":2},{"id":"GO:0034383","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0021670","count":2},{"id":"GO:0051017","count":2}]},{"hash":"989707367567410426","title":"Translation Machinery and tRNA Charging","description":"The cluster's terms are dominated by different aspects of protein synthesis\u2014general translation, mitochondrial translation, and the aminoacylation/charging of tRNAs (glutamyl-tRNA, glutaminyl-tRNAGln via transamidation), along with regulation of translation and ribosomal RNA maturation. This cohesive signal points to a group of proteins involved in ribosome function, tRNA processing, and translation fidelity; the obsolete terms are likely annotation remnants.","confidence":"High","size":17,"edges":135,"triangles":665,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0070681","count":2},{"id":"GO:0006450","count":2},{"id":"GO:0032543","count":2},{"id":"GO:0006424","count":2}]},{"hash":"2174969031669282979","title":"RNA processing and translation initiation control","description":"This cluster shows enrichment for translation-related GO terms (formation of translation preinitiation complex, translation reinitiation) and RNA processing (mRNA splicing via spliceosome), suggesting a role in RNA metabolism and regulation of protein synthesis. Some other terms (cell cycle, GTPase signaling) may reflect broader cellular regulation or annotation noise, but the dominant themes point to RNA processing and translation initiation control.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0080182","count":2}]},{"hash":"1620338633078232058","title":"Golgi-ER-Vacuole Vesicle Trafficking and Exocytosis","description":"The cluster centers on vesicle fusion and transport across Golgi, ER, and vacuole compartments, including intra-Golgi transport, Golgi ribbon formation, and calcium- and neurotransmitter-related exocytosis, indicating a cohesive vesicle trafficking/exocytosis program.","confidence":"High","size":17,"edges":16,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0048280","count":4},{"id":"GO:0006623","count":3},{"id":"GO:0048279","count":3},{"id":"GO:0016320","count":3},{"id":"GO:0071805","count":3}]},{"hash":"649219842443698604","title":"Microtubule dynamics and cytoskeleton organization","description":"The top GO terms emphasize microtubule transport, polarity, chromosome alignment in mitosis, and depolymerization, highlighting a shared focus on microtubule dynamics and cytoskeletal organization (with related neural development terms).","confidence":"High","size":17,"edges":90,"triangles":278,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0033624","count":16},{"id":"GO:0032487","count":16},{"id":"GO:0072383","count":16},{"id":"GO:0030951","count":16},{"id":"GO:0007080","count":16}]},{"hash":"883336684970214514","title":"Neuronal signaling and organelle maintenance","description":"The terms point to a mix of signaling functions (adenylate cyclase activation, regulation of kinase activity, calcium-related muscle regulation) and organelle dynamics/trafficking (mitochondrial inner membrane insertion, peroxisome autophagy, transport/targeting). This suggests a cohesive theme where signaling intersects with organelle maintenance across neural and muscle contexts, rather than a single isolated pathway.","confidence":"Medium","size":17,"edges":59,"triangles":101,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0007190","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0007409","count":3},{"id":"GO:0030242","count":2},{"id":"GO:0006810","count":2}]},{"hash":"757089419560361932","title":"Mitotic progression and proteasome regulation","description":"The top GO terms cluster around mitotic control and proteasome-mediated degradation (G2/M transition, chromosome segregation, exit from mitosis, spindle-checkpoint deactivation) plus ubiquitin-dependent protein catabolism via SCF and DNA repair (NER). While developmental terms appear, the strongest signal is coordinated regulation of mitosis and proteostasis, with a note that the viral process term may reflect virus-host interactions rather than core function. ","confidence":"High","size":17,"edges":135,"triangles":665,"max_degree":16,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0016032","count":17},{"id":"GO:0000086","count":17},{"id":"GO:0007059","count":17},{"id":"GO:0031146","count":17},{"id":"GO:0070911","count":17}]},{"hash":"508808267526914742","title":"Vertebrate organogenesis and neural development","description":"Top terms cluster around development and morphogenesis of multiple organs (endocrine pancreas, pituitary, inner ear, digestive tract, ureteric bud) and neural lineages (neural crest migration, ventral spinal interneuron specification). Coupled with chromatin remodeling and transcriptional regulation, this points to a coordinated vertebrate developmental program.","confidence":"Medium","size":17,"edges":116,"triangles":435,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0031018","count":11},{"id":"GO:0048557","count":10},{"id":"GO:0090190","count":10},{"id":"GO:0001755","count":10}]},{"hash":"1434075890656300057","title":"Macrophage Lipid Remodeling and Immune Regulation","description":"The top GO terms point to macrophage-driven lipid metabolism and remodeling (LDL particle remodeling; phospholipid and phosphatidylethanolamine/acyl-chain remodeling; foam cell differentiation; cholesterol efflux regulation) coupled with immune/inflammatory signaling (ERK/MAPK activation, prostaglandin secretion, macrophage activation, defense against bacteria, and modulation of T cell proliferation). This suggests a cohesive theme of macrophage-mediated lipid processing linked to inflammatory and immune regulatory processes, typical of atherosclerosis-related responses.","confidence":"Medium","size":17,"edges":32,"triangles":11,"max_degree":13,"top_function":"wound healing","top_go_terms":[{"id":"GO:0070374","count":8},{"id":"GO:0010744","count":8},{"id":"GO:0042130","count":5},{"id":"GO:0034374","count":5},{"id":"GO:0036149","count":5}]},{"hash":"4449681554158767","title":"Muscle actin filament assembly and vesicle trafficking","description":"The cluster is enriched for actin-related processes, including actin filament polymerization and skeletal muscle thin filament assembly/development, indicating a muscle-related actin cytoskeleton function. The presence of vesicle transport terms (ER-Golgi and endosome-to-Golgi retrograde transport) and regulation of endocytosis suggests these proteins also participate in cytoskeleton-associated trafficking. Taken together, the dominant theme is muscle actin dynamics with supporting vesicle trafficking roles.","confidence":"High","size":17,"edges":20,"triangles":4,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0030041","count":4},{"id":"GO:0042147","count":4},{"id":"GO:0006890","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0001300","count":3}]},{"hash":"1165807140307782375","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":34,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:2000620","count":3},{"id":"GO:0043045","count":3},{"id":"GO:0048535","count":3},{"id":"GO:0061158","count":3},{"id":"GO:0042787","count":3}]},{"hash":"853093940769219339","title":"Amino acid catabolism and central carbon metabolism","description":"The cluster is dominated by GO terms for amino acid catabolic processes (L-alanine and L-kynurenine) and core carbon metabolism (gluconeogenesis, pyruvate biosynthesis, glyoxylate/glycine related processes), plus an associated iron-sulfur cluster assembly term. Notch signaling appears as a less coherent, outlier term, but the overall pattern centers on amino acid breakdown and central carbon flux. ","confidence":"Medium","size":17,"edges":135,"triangles":665,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042853","count":8},{"id":"GO:0007219","count":8},{"id":"GO:0097053","count":8},{"id":"GO:0019878","count":5},{"id":"GO:0033512","count":5}]},{"hash":"2219007184960503395","title":"Unknown","description":"The cluster contains GO terms spanning neural plasticity, epithelial polarity, immune development, apoptosis, and tissue homeostasis, with no single dominant process. This broad and disparate set suggests multiple tissue contexts rather than a cohesive function, so I cannot assign a specific label beyond Unknown.","confidence":"","size":17,"edges":19,"triangles":3,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:2000463","count":4},{"id":"GO:0060291","count":4},{"id":"GO:0090162","count":4},{"id":"GO:0014911","count":3},{"id":"GO:0071260","count":3}]},{"hash":"1927786488147988993","title":"Lectin and Fc receptor\u2013driven immune signaling","description":"The cluster shows strong enrichment for GO terms related to lectin receptors, Fc-gamma receptor signaling, complement activation via the lectin pathway, and leukocyte tethering/rolling, pointing to innate immune recognition and leukocyte activation; a few developmental terms are present but do not dominate, so the primary theme is immune signaling.","confidence":"Medium","size":17,"edges":6,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060355","count":4},{"id":"GO:0072237","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0050901","count":2},{"id":"GO:0010572","count":2}]},{"hash":"1218205912649223193","title":"Rac-Actin Cytoskeleton Signaling","description":"Top GO terms indicate a core of Rac-regulated actin cytoskeleton dynamics (filopodium assembly, actin organization, substrate adhesion-dependent spreading) and small GTPase\u2013mediated signaling, especially Rac regulation. While NK T cell differentiation and innate immune response appear, the dominant theme is Rac-driven actin remodeling and associated signaling, linking cytoskeletal dynamics to cell adhesion and signaling contexts.","confidence":"High","size":17,"edges":15,"triangles":0,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008286","count":6},{"id":"GO:0046847","count":6},{"id":"GO:1900026","count":6},{"id":"GO:0007264","count":6},{"id":"GO:0001865","count":5}]},{"hash":"2034422257639753882","title":"Golgi-Directed Vesicle Trafficking and Postsynaptic Receptor Insertion","description":"The GO terms point to Golgi apparatus\u2013based vesicle transport (ER-to-Golgi, intra-Golgi, ribbon formation), SNARE complex assembly, and vesicle fusion, plus exocytic insertion of neurotransmitter receptors at the postsynaptic membrane and links to excitatory signaling and LTP. Together these indicate a cohesive role in Golgi-mediated trafficking that delivers receptors to the synapse, influencing synaptic strength.","confidence":"High","size":17,"edges":40,"triangles":53,"max_degree":16,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006891","count":10},{"id":"GO:1903358","count":10},{"id":"GO:0060291","count":10},{"id":"GO:0090161","count":10},{"id":"GO:0035493","count":10}]},{"hash":"1020945222588006854","title":"Regulated signaling and exocytosis","description":"GO term enrichment centers on regulation of signaling pathways (integrin, Hippo, glucocorticoid) and vesicle-mediated processes (exocytosis), with hints of kinase activity control. The common thread appears to be modulators of signal transduction and secretion rather than a single pathway, supporting a label centered on regulated signaling and exocytosis.","confidence":"Medium","size":17,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":3},{"id":"GO:0030579","count":3},{"id":"GO:0035331","count":3},{"id":"GO:0006887","count":3},{"id":"GO:0072284","count":3}]},{"hash":"1651015388365097522","title":"Heart-related cytoskeletal dynamics and signaling","description":"This cluster centers on actin cytoskeleton\u2013related processes (actin cortical patch assembly, endocytosis), cell adhesion, and Rho/JNK signaling, with an additional signal related to heart development. The co-occurrence of heart development with cytoskeletal and adhesion pathways suggests a cohesive theme of cytoskeleton remodeling coupled to signaling in heart-related cell behavior.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0010863","count":4},{"id":"GO:0007155","count":4},{"id":"GO:0035023","count":4}]},{"hash":"1170487241575494991","title":"Cytokine-Driven Inflammatory Response","description":"The cluster is enriched for GO terms tied to cellular responses to TNF, LPS, IL-1, and regulation of IL-6 production, pointing to innate immune and inflammatory signaling. The presence of an extrinsic apoptotic signaling term suggests connections to inflammation-associated cell death, with additional transcriptional regulation consistent with downstream inflammatory responses. A few unrelated terms (phospholipid homeostasis, visual perception) appear as incidental annotations but do not define the core function. ","confidence":"Medium","size":17,"edges":31,"triangles":12,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0071356","count":6},{"id":"GO:0071222","count":6},{"id":"GO:0050729","count":6},{"id":"GO:2000778","count":5},{"id":"GO:0071347","count":5}]},{"hash":"1915568553476181142","title":"Neural development and organogenesis signaling","description":"This cluster is enriched for nervous system development, neuronal guidance pathways (Roundabout/ROBO and SHH/Smoothened), and organogenesis processes (kidney and heart development). It also includes neural interneuron migration, angiogenesis, and receptor tyrosine kinase signaling, forming a cohesive theme of developmental signaling governing neural patterning and organ formation.","confidence":"High","size":17,"edges":130,"triangles":605,"max_degree":16,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035385","count":13},{"id":"GO:0007399","count":13},{"id":"GO:0007224","count":13},{"id":"GO:0001822","count":13},{"id":"GO:0007507","count":12}]},{"hash":"472831352445191401","title":"Developmental transcriptional regulation","description":"The cluster is dominated by GO terms for transcriptional control (negative regulation of transcription by RNA polymerase II, DNA-templated transcription, and RNA polymerase II regulatory region DNA binding) alongside multiple morphogenesis and patterning terms (cartilage morphogenesis, left/right pattern formation, hair follicle morphogenesis, roof of mouth development, placenta-related development). This pattern points to proteins that regulate gene expression to drive developmental processes. A minor term about ribosomal subunit export is likely incidental. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0060536","count":8},{"id":"GO:0060972","count":8},{"id":"GO:1903026","count":8},{"id":"GO:0006351","count":8}]},{"hash":"260578441030572539","title":"Spliceosome-Mediated RNA Splicing Regulation","description":"The leading GO terms cluster around mRNA splicing via the spliceosome and regulation of splicing, with a link to RNA Pol II CTD phosphorylation, suggesting a core function in RNA processing and spliceosome-mediated regulation. Some outlier terms (UV-A response, proviral latency, sepal formation) appear but are less represented, so the primary theme is splicing regulation.","confidence":"Medium","size":17,"edges":134,"triangles":651,"max_degree":16,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":12},{"id":"GO:0045292","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0071492","count":6}]},{"hash":"1321151859655062282","title":"Growth factor signaling and cell migration","description":"This cluster consistently shows GO terms tied to growth factor\u2013driven signaling (TGF-beta, PDGF), activation of signaling cascades (ERK, calcium signaling, STAT phosphorylation), and processes involving cell movement and morphogenesis (neutrophil chemotaxis, branching morphogenesis). The shared theme is growth factor\u2013mediated signaling that regulates cell migration and tissue development.","confidence":"High","size":17,"edges":121,"triangles":481,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071560","count":17},{"id":"GO:0014911","count":17},{"id":"GO:0036120","count":17},{"id":"GO:0070374","count":17},{"id":"GO:0050850","count":17}]},{"hash":"1990362100305546512","title":"Spliceosome-Driven mRNA Processing and Regulation","description":"The cluster centers on mRNA maturation and post-transcriptional control, with strong representation of spliceosome-mediated splicing, regulatory splicing, polyadenylation, export, and stability in stress responses, suggesting a cohesive group of proteins involved in mRNA processing and regulation.","confidence":"High","size":17,"edges":18,"triangles":0,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":14},{"id":"GO:0006378","count":14},{"id":"GO:0048026","count":13},{"id":"GO:0031047","count":13},{"id":"GO:0010610","count":13}]},{"hash":"811389090844078897","title":"Neuronal signaling and sensory perception","description":"This cluster centers on neural communication and sensory processing, highlighted by dopaminergic synaptic transmission, visual perception/learning, pain signaling, and behavioral modulation by drugs, with supporting signaling pathway regulators (ERK cascade, GTPase activity) and prostaglandin response cues. Together, these terms point to a cohesive theme of neural signaling and sensory/behavioral modulation.","confidence":"Medium","size":17,"edges":122,"triangles":500,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":12},{"id":"GO:0070374","count":12},{"id":"GO:0048148","count":12},{"id":"GO:0010759","count":12},{"id":"GO:0019233","count":12}]},{"hash":"1121063675149011669","title":"Brain signaling and sensory processing","description":"The top GO terms overwhelmingly point to brain functions: visual perception/learning, sensory perception of pain, behavioral responses to drugs (cocaine, morphine), brain renin-angiotensin system, and ERK/MAPK signaling via protein phosphorylation. Heart development appears as an outlier, but the dominant theme is neural signaling and sensory processing in the brain.","confidence":"High","size":17,"edges":96,"triangles":264,"max_degree":15,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":16},{"id":"GO:0070374","count":16},{"id":"GO:0048148","count":16},{"id":"GO:0010759","count":16},{"id":"GO:0019233","count":16}]},{"hash":"576419653680639474","title":"Dopaminergic signaling and sensory perception","description":"The top GO terms cluster around neuronal signaling and perception: dopaminergic synaptic transmission, visual perception and learning, sensory perception of pain, cocaine response, and ERK cascade regulation with protein phosphorylation. This suggests a module focused on dopamine-related signaling, sensory processing, and activity-dependent plasticity. Some terms like heart development and macrophage chemotaxis may reflect pleiotropic components, but the dominant theme is neuronal signaling and sensory modulation.","confidence":"High","size":17,"edges":85,"triangles":153,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":14},{"id":"GO:0070374","count":14},{"id":"GO:0048148","count":14},{"id":"GO:0010759","count":14},{"id":"GO:0019233","count":14}]},{"hash":"1179464379542863080","title":"Cerebellar development and signaling regulation","description":"The top GO terms include cerebellar cortex formation and Bergmann glial cell differentiation, alongside regulation of ERK/MAPK signaling, insulin receptor signaling, and cell cycle regulators. This pattern points to a core function in cerebellar development tied to coordinated signaling control, despite some ancillary terms. ","confidence":"High","size":17,"edges":131,"triangles":609,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000200","count":13},{"id":"GO:0070373","count":13},{"id":"GO:0050860","count":13},{"id":"GO:0034501","count":11},{"id":"GO:0045736","count":11}]},{"hash":"2153390710901008146","title":"Innate Immunity, Pain, and Thermoregulation","description":"The cluster is enriched for innate immune processes (negative regulation of TNF production, neutrophil chemotaxis and killing, eosinophil degranulation) and nociceptive/thermoregulatory signals (sensory perception of pain, cellular response to temperature stimulus, diet-induced thermogenesis). While some tissue-specific terms appear (retina/lung development), the dominant theme ties immune/inflammatory activity with temperature and pain responses, justifying this label.","confidence":"High","size":17,"edges":14,"triangles":1,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032720","count":15},{"id":"GO:0090023","count":15},{"id":"GO:0019233","count":15},{"id":"GO:0002024","count":15},{"id":"GO:0071502","count":15}]},{"hash":"358729673727508976","title":"Unknown","description":"The top GO terms are diverse, covering retina development and visual learning, sensory perception, metabolism/thermogenesis, cell proliferation, GPase signaling, eosinophil chemotaxis, and saliva secretion, with no clear common function or pathway linking them, and there are no edges connecting proteins. This lack of a coherent theme justifies an Unknown label.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060041","count":6},{"id":"GO:0008542","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0008283","count":6},{"id":"GO:0019233","count":6}]},{"hash":"1441621790269346517","title":"GPCR-cAMP signaling and immune modulation","description":"The top GO terms cluster around activation of adenylate cyclase and adenylate cyclase-activating GPCR signaling pathways, along with calcium signaling, indicating GPCR-cAMP mediated signaling. Immune-related terms (eosinophil degranulation, neutrophil killing) point to immune modulation, while vascular-related terms (blood pressure, endothelial barrier) and tissue-development terms provide context for GPCR signaling in vascular/lining tissues. A few terms (retina development, electron transport) are broader annotations but do not override the dominant GPCR-cAMP/immune theme. Overall this label captures the most coherent functional thread across the cluster, with some peripheral terms.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":15},{"id":"GO:0045777","count":15},{"id":"GO:0022900","count":15},{"id":"GO:0010579","count":15},{"id":"GO:0043311","count":14}]},{"hash":"489673762123165836","title":"Developmental gene regulation and chromatin remodeling","description":"Most prominent terms relate to development (bile duct development, otic vesicle formation, neural crest migration, budding growth) and to regulation of transcription and chromatin state (RNA Pol II repression, DNA binding regulation, nucleosome disassembly, histone acetylation). This indicates a coherent cluster of proteins coordinating gene expression during development via chromatin remodeling and transcriptional control.","confidence":"Medium","size":17,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035622","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0001755","count":3},{"id":"GO:0043388","count":3},{"id":"GO:0030916","count":3}]},{"hash":"875384325461545648","title":"Regulation of mRNA splicing and stability","description":"The cluster is strongly enriched for GO terms related to spliceosome-mediated mRNA processing, including regulation and positive regulation of mRNA splicing, mRNA stability/decay, splice site recognition, and mRNA export. This indicates a cohesive group of proteins functioning in post-transcriptional regulation, especially splicing, as well as mRNA maturation and turnover.","confidence":"High","size":17,"edges":122,"triangles":501,"max_degree":16,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":13},{"id":"GO:0000381","count":11},{"id":"GO:0048026","count":10},{"id":"GO:0031047","count":10},{"id":"GO:0048255","count":10}]},{"hash":"1708740670893775426","title":"Neural development and motor neuron differentiation","description":"The top GO terms converge on neural tissue development, especially motor neurons and spinal cord patterning (axon guidance, neuron fate specification, interneuron specification). Although a few terms touch other tissues (gonad, uterine epithelium), the prevailing signals are neural development processes, particularly motor neuron lineage and spinal cord organization.","confidence":"Medium","size":17,"edges":59,"triangles":15,"max_degree":11,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0021937","count":16},{"id":"GO:0008585","count":16},{"id":"GO:0072283","count":16},{"id":"GO:0008045","count":16},{"id":"GO:0001705","count":16}]},{"hash":"1469271981228976831","title":"Negative Regulation of TGF-\u03b2/BMP Signaling","description":"This cluster is dominated by GO terms related to inhibiting BMP signaling, TGF-\u03b2 receptor signaling, and SMAD-dependent transduction, with several entries explicitly describing negative regulation. Additional terms about negative regulation of fibroblast proliferation and osteoblast differentiation, along with a lens differentiation term, fit within the broader theme of BMP/TGF-\u03b2 pathway control and its developmental and cellular proliferation effects. Overall, the proteins appear to function primarily to attenuate TGF-\u03b2/BMP signaling and its downstream SMAD activities.","confidence":"High","size":17,"edges":37,"triangles":0,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030514","count":8},{"id":"GO:0060395","count":7},{"id":"GO:0007179","count":7},{"id":"GO:0070306","count":7},{"id":"GO:0010944","count":7}]},{"hash":"164019648154950748","title":"Immune signaling and tissue regeneration","description":"These proteins cluster around immune signaling (MHC II biosynthesis regulation; IL-4 response; cytokine production) and tissue maintenance/remodeling (vascular wound healing; liver regeneration; osteoblast differentiation), with links to cellular stress responses (PERK-mediated unfolded protein response) and developmental cues. The common thread appears to be signaling networks coordinating immune activity with tissue regeneration and stress responses, rather than a single cohesive function.","confidence":"Medium","size":17,"edges":134,"triangles":651,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":10},{"id":"GO:0045348","count":8},{"id":"GO:0035470","count":8},{"id":"GO:0036499","count":7},{"id":"GO:0007381","count":7}]},{"hash":"625763901001965078","title":"Neurodevelopmental signaling and axon guidance","description":"The top GO terms cluster around neural development and signaling pathways critical for CNS patterning and connectivity, notably brain and nervous system development along with Roundabout (ROBO) and Smoothened (Hedgehog) signaling. The inclusion of regulation of synaptic vesicle exocytosis further supports a neuronal, synaptic function theme. Some terms like kidney development and T cell receptor signaling appear but are secondary to the core neural development/signaling pattern.","confidence":"High","size":17,"edges":105,"triangles":304,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":5},{"id":"GO:0035385","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0001822","count":4}]},{"hash":"1282731904647380879","title":"Embryonic Development and Morphogenesis","description":"The top GO terms indicate broad involvement in embryonic development and tissue formation across multiple lineages, including craniofacial (palate), cartilage, hair follicle morphogenesis, mesoderm formation, left/right patterning, EMT-related heart/cushion formation, and endocrine organ development. This pattern points to a cohesive role in developmental programs rather than a single tissue or pathway, suggesting these proteins participate in general embryogenesis and morphogenesis.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":13},{"id":"GO:0060536","count":12},{"id":"GO:0060972","count":12},{"id":"GO:0060806","count":12},{"id":"GO:0031069","count":12}]},{"hash":"1619631440562909164","title":"Neuronal development and synaptic trafficking","description":"The top GO terms cluster around neural development (substantia nigra development) and synaptic function (synaptic vesicle budding) along with signaling and trafficking processes essential for neurons, including GPCR-mediated signaling, GTPase regulation, filopodium/cytoskeletal dynamics, and ER-to-Golgi vesicle transport. This suggests a theme of neuronal maturation, signaling, and vesicle handling rather than general cellular metabolism, justifying a neuronal signaling/trafficking label.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021762","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0051489","count":2},{"id":"GO:0007213","count":2}]},{"hash":"1282288163098939855","title":"Ubiquitin-Dependent Proteostasis and Innate Immunity","description":"The top GO terms are dominated by ubiquitin-mediated protein degradation (ubiquitin-dependent proteolysis, polyubiquitination, autoubiquitination, ERAD pathway) and innate antiviral defense (defense and innate immune responses), suggesting a cluster centered on ubiquitin-proteasome\u2013driven proteostasis with links to antiviral immunity. The presence of histone ubiquitination and related epigenetic terms hints at additional regulation of chromatin. Overall, this cluster appears to group proteins involved in ubiquitin-dependent turnover and immune-related regulation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0000209","count":9},{"id":"GO:0030433","count":8},{"id":"GO:0051607","count":8},{"id":"GO:0045087","count":8}]},{"hash":"2251270429108565702","title":"Neuroimmune Pain Processing","description":"The top GO terms cluster around neural signaling and pain-related processes (regulation of sensory perception of pain, negative regulation of glutamatergic synaptic transmission, prepulse inhibition, visual learning, responses to morphine and amphetamine) together with immune/inflammatory responses (inflammatory response, response to lipopolysaccharide, blood coagulation). This suggests a theme of neuroimmune interactions influencing pain processing and behavior. The cell wall macromolecule catabolic process appears as a peripheral outlier. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016998","count":15},{"id":"GO:0043278","count":15},{"id":"GO:0051967","count":15},{"id":"GO:0051930","count":15},{"id":"GO:0060134","count":15}]},{"hash":"1199830945871928815","title":"Ubiquitin-Dependent Antiviral Immune Response","description":"These proteins show strong enrichment for ubiquitin-dependent protein catabolic processes and polyubiquitination alongside antiviral and immune signaling terms (defense response to virus; innate and adaptive immune responses; regulation of RIG-I signaling). This suggests a cluster centered on ubiquitin-regulated antiviral immune signaling, rather than a muscle-specific function; the circadian and sarcomere terms may reflect broader regulatory links or annotation spillover.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0051607","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0000209","count":7},{"id":"GO:0007026","count":7}]},{"hash":"1915199804469308491","title":"Immune Activation and Regulation","description":"The cluster is dominated by GO terms tied to both innate and adaptive immune responses, including phagocytosis, leukocyte trafficking, and regulation of T cell, NK cell, and macrophage activity, as well as IL-10 production. This suggests a coherent theme of immune activation coupled with regulatory control.","confidence":"High","size":17,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046007","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0002250","count":6},{"id":"GO:0006910","count":6},{"id":"GO:0072672","count":5}]},{"hash":"2155162396164269253","title":"Adhesion and actin-cytoskeleton remodeling","description":"Top GO terms emphasize actin crosslinking, tight junction assembly, cell adhesion, and Rho signaling, implying a cluster focused on adhesion-cytoskeleton coordination and cell migration; other signaling responses to growth factors reflect broader regulatory context.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051764","count":6},{"id":"GO:0070830","count":6},{"id":"GO:0007155","count":6},{"id":"GO:0035023","count":6},{"id":"GO:0035156","count":5}]},{"hash":"1536028030060377558","title":"Innate Immune Activation and Inflammatory Signaling","description":"This cluster's top GO terms center on immune responses and inflammation: positive regulation of eosinophil degranulation, neutrophil-mediated killing of Gram-negative bacteria, dendritic cell chemotaxis, and response to lipopolysaccharide. Some terms also touch tissue development (lung connective tissue, heart, retina) and endothelial barrier regulation, suggesting inflammatory signaling can influence tissue remodeling. Taken together, the proteins appear to participate in innate immune signaling and inflammatory processes, with broad tissue-related effects rather than a single organ-specific function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":17},{"id":"GO:0060427","count":17},{"id":"GO:0070963","count":17},{"id":"GO:0051482","count":17},{"id":"GO:0060041","count":17}]},{"hash":"1073158911683169190","title":"Immune Activation and Organ Development","description":"The top GO terms are largely immune-related (eosinophil degranulation, neutrophil killing of gram-negative bacteria, response to LPS, dendritic cell chemotaxis) indicating immune signaling activity. They also include developmental terms across lung, retina, heart, and endothelial barrier, suggesting a broad developmental program. The combination implies a cluster enriched for immune response genes with ancillary roles in tissue development, so the label reflects both aspects.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":17},{"id":"GO:0060427","count":17},{"id":"GO:0070963","count":17},{"id":"GO:0051482","count":17},{"id":"GO:0060041","count":17}]},{"hash":"1610602105535859946","title":"Unknown","description":"The GO terms are heterogeneous, spanning tissue development (lung, retina, heart, endothelium) and immune responses (eosinophil/neutrophil degranulation, LPS response) with no single shared function, and the cluster has no interactions, so a cohesive label cannot be determined.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":17},{"id":"GO:0060427","count":17},{"id":"GO:0070963","count":17},{"id":"GO:0051482","count":17},{"id":"GO:0060041","count":17}]},{"hash":"567476468388378266","title":"T cell activation and immune regulation","description":"The cluster is dominated by GO terms for T cell costimulation, regulation of T cell proliferation, IL-2 and IL-10 production, and NK cell\u2013mediated cytotoxicity against tumor cells, suggesting a coherent theme of adaptive immune activation and tumor surveillance. An outlier term on spermatid development is likely noise or misannotation, but the majority of terms point to T cell\u2013mediated immune response and regulation. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0031295","count":8},{"id":"GO:0043031","count":7},{"id":"GO:2001181","count":7},{"id":"GO:0007286","count":7},{"id":"GO:0042102","count":7}]},{"hash":"1652263685583028251","title":"Antiviral and Immune Signaling Cluster","description":"The GO terms point to antiviral defense and immune signaling (defense response to virus, interferon-beta response, TNF signaling, T and B cell proliferation regulation). Coupled with terms for ERK cascade regulation and GTPase activation, there is a theme of modulated signaling pathways. Mentioned vesicle trafficking terms (recycling endosome to Golgi, late endosome to Golgi) suggest involvement of intracellular transport that supports receptor signaling. An outlier term for cerebral cortex development is likely incidental noise; overall, the cluster centers on immune communication and antiviral responses.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021987","count":3},{"id":"GO:0071955","count":2},{"id":"GO:0034499","count":2},{"id":"GO:0090630","count":2},{"id":"GO:0030889","count":2}]},{"hash":"609021548177955010","title":"Unknown","description":"The annotated GO terms span several unrelated biological areas (muscle calcium signaling, nervous system structure, chromatin modification, immune differentiation, and barrier formation), with no clear shared pathway or function tying all 17 proteins together into a single coherent theme. Therefore a specific, representative label cannot be determined.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010881","count":3},{"id":"GO:0021629","count":3},{"id":"GO:0010520","count":3},{"id":"GO:0000183","count":3},{"id":"GO:1902083","count":3}]},{"hash":"77096597006996429","title":"Rho-Driven Actin Remodeling","description":"This cluster is dominated by terms tied to actin cytoskeleton organization, actin filament polymerization, actin crosslink formation, and regulation of GTPase activity, particularly Rho signaling. The inclusion of regulation of Rho protein signal transduction and plasma membrane tubulation supports a theme of cytoskeletal dynamics and membrane remodeling governed by Rho GTPases. While there are occasional mentions of cell cycle and proliferation, the core pattern points to actin dynamics driven by Rho pathways.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0097320","count":3},{"id":"GO:0046626","count":3},{"id":"GO:0030036","count":3},{"id":"GO:0043547","count":3}]},{"hash":"194016887431565523","title":"Calcium signaling and transcription regulation","description":"The terms point to calcium as a central mediator: multiple entries involve calcium ion transport and calcium-modulated signaling, including phosphatidylinositol-mediated pathways and calcium signaling cascades. Regulators of the calcineurin-NFAT axis and GTPase activity link signaling to transcription, reflected by DNA-templated transcription. Some terms also touch on stress-related cardiac hypertrophy, consistent with calcium signaling roles in heart. Taken together, the cluster likely comprises proteins involved in calcium-dependent signal transduction that culminates in transcriptional control.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0051531","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0014898","count":3}]},{"hash":"714847455112464021","title":"Angiogenesis and skeletal development signaling","description":"This cluster centers on skeletal system development and angiogenesis, with several growth-factor signaling pathways highlighted (positive regulation of ERK/MAPK cascade, VEGF/PDGF receptor signaling, erythropoietin signaling). While some terms touch on hematopoietic and immune signaling (myeloid differentiation, Fc receptor signaling), the strongest shared theme is vascular and bone-development signaling networks. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0070374","count":3},{"id":"GO:2000830","count":3},{"id":"GO:0043552","count":3}]},{"hash":"971995164510100839","title":"Embryonic morphogenesis and organ development","description":"This cluster is dominated by GO terms linked to embryonic development and tissue morphogenesis across multiple lineages (mesoderm, cartilage, palate, and heart processes, including left-right patterning and EMT in heart development). The common theme is developmental morphogenesis and organ formation rather than a single cell-type or pathway, making this concise label representative of the cluster.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031069","count":14},{"id":"GO:0035270","count":14},{"id":"GO:0007498","count":14},{"id":"GO:0010957","count":14},{"id":"GO:0060972","count":14}]},{"hash":"1787292896897612562","title":"Developmental signaling and tissue organization","description":"Top GO terms indicate regulatory signaling across neural, vascular, and cardiac contexts (ephrin receptor signaling regulation, regulation of synaptic plasticity by receptor localization to synapse, establishment of epithelial cell polarity, cardiac right atrium morphogenesis, regulation of SA node cell action potential, venous endothelial differentiation). The mix suggests a broad theme of signaling networks coordinating tissue development and organization, with a few outliers in miRNA silencing and lipid catabolism. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901187","count":4},{"id":"GO:1900383","count":4},{"id":"GO:2000637","count":3},{"id":"GO:0090162","count":3},{"id":"GO:0050960","count":3}]},{"hash":"1264298236613258511","title":"Diverse solute transporters","description":"The Top Terms are dominated by transmembrane transport across a wide range of substrates (nitrate, nitrite, phosphate, galactose, 4-hydroxyphenylacetate, vitamins, xenobiotics) and even neurotransmitter loading into synaptic vesicles, pointing to a cluster of membrane transporter proteins with broad solute specificity. The single erythrocyte development term is a minor outlier and does not guide the overall label.","confidence":"High","size":16,"edges":38,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0048823","count":2},{"id":"GO:0015706","count":2},{"id":"GO:1900754","count":2},{"id":"GO:0035435","count":2},{"id":"GO:0042128","count":2}]},{"hash":"1649779938606021530","title":"Dopaminergic neural development and signaling","description":"The top GO terms cluster around brain development in the substantia nigra, dopaminergic signaling (amphetamine response), calcium-regulated processes affecting heart rate, and astrocyte activation, all tying to neural dopaminergic function and calcium-dependent signaling. Mitochondrial cristae formation and actin crosslinking hint at energy and cytoskeletal dynamics relevant to neurons and glia, supporting a cohesive theme of nigrostriatal development and dopaminergic signaling with associated calcium and metabolic regulation.","confidence":"Medium","size":16,"edges":15,"triangles":0,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021762","count":4},{"id":"GO:0051000","count":4},{"id":"GO:0042407","count":3},{"id":"GO:0010881","count":3},{"id":"GO:0001975","count":3}]},{"hash":"56585444970669176","title":"Developmental Regulation and ECM Remodeling","description":"The cluster shows enrichment for extracellular matrix organization and negative regulation of angiogenesis, along with developmental differentiation terms such as sensory organ precursor fate determination and imaginal disc fusion, indicating a theme of tissue morphogenesis and lineage specification. It also includes transcriptional regulation terms, suggesting coordinated control of gene expression during development.","confidence":"Medium","size":16,"edges":9,"triangles":0,"max_degree":9,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0016525","count":3},{"id":"GO:0030198","count":3},{"id":"GO:0030579","count":2},{"id":"GO:0046529","count":2},{"id":"GO:0016360","count":2}]},{"hash":"1072628707619616291","title":"Brain development and sensory signaling","description":"The cluster\u2019s top terms include forebrain neuron development, phototransduction, maternal behavior, and a GPCR signaling pathway, all pointing to neural development and sensory processing. While other terms touch on general protein modification and metabolic regulation, the strongest theme is brain/neuronal functions, suggesting the proteins are enriched for neural development and signaling roles.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010906","count":2},{"id":"GO:1990355","count":1},{"id":"GO:0030091","count":1},{"id":"GO:0070301","count":1},{"id":"GO:0006464","count":1}]},{"hash":"946303072317588933","title":"Paranodal Axon Junction Assembly and Cytoskeleton Regulation","description":"The top GO terms cluster around paranodal/juxtaparanodal axon regions (paranodal junction assembly, protein localization to paranode/juxtaparanode) and cytoskeletal dynamics (regulation of actin cytoskeleton reorganization, regulation of Rho signaling), with supporting trafficking signals (receptor internalization, cellular response to cAMP). This suggests a cohesive role in organizing axon terminal domains and modulating the cytoskeleton and trafficking there.","confidence":"High","size":16,"edges":19,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0030913","count":4},{"id":"GO:0045765","count":3},{"id":"GO:0071205","count":3},{"id":"GO:2000249","count":3},{"id":"GO:0071320","count":3}]},{"hash":"2030357765599401752","title":"Cytoskeletal remodeling and cell junctions","description":"Dominant terms point to actin-driven processes (lamellipodium assembly; actomyosin structure organization) and cell\u2013cell junctions (tight junction assembly; endothelial barrier establishment), suggesting a cluster of proteins coordinating cytoskeletal dynamics with barrier integrity. Some neural-related terms appear as potential noise, but the core theme is cytoskeletal restructuring and junctional organization.","confidence":"Medium","size":16,"edges":38,"triangles":30,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":3},{"id":"GO:0021702","count":2},{"id":"GO:0060396","count":2},{"id":"GO:0031032","count":2},{"id":"GO:0007605","count":2}]},{"hash":"1921625892693462205","title":"Neural and Heart Development Signaling","description":"These proteins are enriched for neural development (neurotrophin TRK signaling, hippocampus development) and heart development, with connected growth-control (Hippo signaling) and broader developmental cues (estradiol response, LPS response, apoptosis, B cell regulation, platelet formation). This pattern points to a cluster of multifunctional signaling networks coordinating neural and cardiovascular development, growth, and cell fate decisions.","confidence":"High","size":16,"edges":46,"triangles":39,"max_degree":9,"top_function":"wound healing","top_go_terms":[{"id":"GO:0048011","count":10},{"id":"GO:0051092","count":10},{"id":"GO:0007507","count":9},{"id":"GO:0032496","count":9},{"id":"GO:0021766","count":9}]},{"hash":"807400440819400875","title":"Integrin signaling and actin-based protrusions in EMT","description":"The proteins are enriched for integrin activation/regulation, filopodium and lamellipodium assembly, and Rho signaling, plus processes like epithelial-to-mesenchymal transition and TGF-beta signaling, all pointing to coordinated cytoskeletal remodeling and migratory behavior. This suggests a convergence on cell adhesion and motility rather than purely metabolic roles.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0002814","count":4},{"id":"GO:0033622","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0033623","count":4},{"id":"GO:0035023","count":4}]},{"hash":"1044291824462736602","title":"Steroidogenesis and gonadal development","description":"This cluster is strongly enriched for testosterone biosynthesis, androgen metabolism, and female gonad/genitalia development, pointing to steroid hormone production and gonadal differentiation. The inclusion of cholesterol, retinoic acid, vitamin D, and xenobiotic catabolic processes suggests related lipid/sterol metabolism and detoxification activities typical of steroidogenic tissues, indicating a cohesive theme around hormone metabolism and gonadal development.","confidence":"Medium","size":16,"edges":21,"triangles":2,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0061370","count":6},{"id":"GO:0042904","count":6},{"id":"GO:0008209","count":6},{"id":"GO:1900087","count":5},{"id":"GO:0008585","count":5}]},{"hash":"1866225487627914635","title":"Multisystem Signal Transduction","description":"The top GO terms suggest involvement in signaling across diverse systems: responses to xenobiotic stimuli, TGF-beta, T cell receptor signaling, and cyclic nucleotide\u2013mediated pathways, alongside cardiac muscle regulation and phototransduction. This points to a broad, stimulus-driven signaling cluster rather than a single, cohesive pathway, covering immune, endocrine, cardiac, and sensory contexts.","confidence":"Medium","size":16,"edges":17,"triangles":4,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035690","count":7},{"id":"GO:0071560","count":7},{"id":"GO:0050852","count":7},{"id":"GO:0019933","count":6},{"id":"GO:0010446","count":5}]},{"hash":"1331797815476339988","title":"Ubiquitin-Dependent Proteolysis and NF-\u03baB Signaling","description":"The cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes, including ubiquitin-dependent ERAD, SCF-proteasomal pathways, polyubiquitination, and autoubiquitination, which point to core proteasomal degradation mechanisms. Several terms also link to regulation of NF-\u03baB signaling and TNF-mediated pathways, indicating a role in ubiquitin-mediated signaling control. A minor connection to circadian rhythm regulation is present, but the central theme remains ubiquitin-driven proteolysis and its influence on signaling pathways.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0030433","count":7},{"id":"GO:0070534","count":6},{"id":"GO:0042752","count":6},{"id":"GO:1903265","count":5}]},{"hash":"1544383274907343530","title":"DNA-templated transcription and transposition","description":"This cluster is dominated by GO terms tied to transcription initiated from DNA templates (DNA-templated transcription, RNA Pol II regulation) and DNA mobility (DNA transposition, DNA integration), plus RNA-templated DNA biosynthesis, suggesting retrotransposition-like activity and genome remodeling. A few terms reflect host\u2013symbiont interactions, indicating additional context, but the core theme centers on transcription from DNA and DNA mobility processes. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006278","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0061014","count":3},{"id":"GO:0044828","count":3}]},{"hash":"944699193358196581","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001731","count":6},{"id":"GO:0002188","count":5},{"id":"GO:0000398","count":5},{"id":"GO:0008283","count":4},{"id":"GO:0000447","count":4}]},{"hash":"982160406705988142","title":"Unknown","description":"The terms span endocytosis, signaling, development, metabolism, and immune response with no single cohesive function tying them together; the mix includes caveolin-mediated endocytosis and sphingolipid biosynthesis alongside neuron development and cytokine response, making a precise label unreliable. None","confidence":"","size":16,"edges":93,"triangles":269,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0072584","count":16},{"id":"GO:0033598","count":16},{"id":"GO:1990804","count":16},{"id":"GO:0007098","count":16},{"id":"GO:0043506","count":16}]},{"hash":"638965448848290643","title":"Cell-Cell Adhesion and Synapse Assembly","description":"Based on the prevalence of GO terms related to cell-cell adhesion (heterophilic adhesion, paranodal junction assembly, AV node cell adhesion), regulation of synapse assembly, and actin cytoskeleton organization driven by adhesion, this cluster seems centered on adhesion-mediated junctions and synaptic organization. Some immune regulation terms and host interaction terms may reflect broader cell-interface signaling but do not override the adhesion/synapse theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":3},{"id":"GO:0002859","count":3},{"id":"GO:0043031","count":3},{"id":"GO:0043318","count":3},{"id":"GO:0090138","count":3}]},{"hash":"743962332784785499","title":"Ribosome Biogenesis and rRNA Processing","description":"Dominant GO terms show maturation of LSU and 5.8S rRNA, ribosome biogenesis, and large subunit biogenesis, indicating a cluster of proteins involved in ribosome assembly and rRNA processing. Supporting signals like DNA-templated transcription and TORC1 signaling suggest coordinated regulation of ribosome production. Some terms (cadmium response, macrophage foam cell differentiation, histone acetylation) may reflect broader cellular contexts or regulatory links rather than core ribosome functions.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":7},{"id":"GO:0035948","count":7},{"id":"GO:0042254","count":6},{"id":"GO:0071276","count":5},{"id":"GO:0006351","count":5}]},{"hash":"754773522788359297","title":"GPCR-Mediated Signaling and Vascular Regulation","description":"The top GO terms center on GPCR signaling and activation of adenylate cyclase, with related roles in blood pressure control and endothelial barrier function, plus immune cell degranulation. Tissue development terms for lung and retina and the presence of an electron transport chain term suggest a broader vesicle of GPCR-related signaling impacting vascular, immune, and developmental processes. ","confidence":"Medium","size":16,"edges":5,"triangles":1,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0010579","count":14},{"id":"GO:0007190","count":13},{"id":"GO:0043311","count":12}]},{"hash":"1585607172207123855","title":"Developmental signaling and axis formation","description":"This cluster centers on embryonic development processes: Wnt and GPCR signaling, axis elongation/convergent extension, and notochord formation, plus neural development elements like axon fasciculation and apoptosis, all pointing to morphogenesis driven by signaling pathways.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035021","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0051225","count":3},{"id":"GO:0060044","count":2}]},{"hash":"2046743869824549324","title":"Neuronal GPCR-MAPK signaling and dendrite regulation","description":"The top GO terms point to neuronal signaling and kinase activity: excitatory postsynaptic potential, morphine response, ERK cascade, and thrombin receptor signaling all implicate GPCR-mediated signaling and MAPK pathways in neurons. Additional terms about dendrite morphogenesis regulation and phosphorylation reinforce a theme of synaptic signaling and structural modulation. The presence of P-body assembly suggests RNA-regulatory processes in neurons as well, possibly linked to local translation in dendrites. Overall, the cluster seems best described by neuronal GPCR-MAPK signaling with dendrite regulation, albeit with a side note of RNA regulation. ","confidence":"Medium","size":16,"edges":28,"triangles":17,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060079","count":5},{"id":"GO:0043278","count":5},{"id":"GO:0050774","count":4},{"id":"GO:0050732","count":4},{"id":"GO:0033962","count":4}]},{"hash":"1048744396824473526","title":"RNA Transcription and mRNA Export Regulation","description":"Based on the GO terms, the proteins are mainly linked to transcriptional regulation and RNA synthesis/processing (RNA polymerase II/III activity, RNA-templated transcription, mRNA export regulation). A few entries touch on apoptotic signaling, but the dominant theme is transcription-related processes, so this label best captures the cluster\u2019s core function without overreaching.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097190","count":3},{"id":"GO:0051571","count":2},{"id":"GO:0051573","count":2},{"id":"GO:0010452","count":2},{"id":"GO:0031564","count":2}]},{"hash":"271566629364193155","title":"Neural development and synaptic function","description":"This cluster is dominated by neural-related terms: spinal cord development, myelination, adult locomotory behavior, and positive regulation of synaptic vesicle recycling, pointing to neuronal development and synaptic activity. While other terms (insulin signaling, heart development, and general cellular processes) appear, they are less coherent with the neural emphasis, so the overall theme centers on neural growth and synaptic function rather than a single clear pathway.","confidence":"Medium","size":16,"edges":20,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0008344","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0007117","count":2},{"id":"GO:0017183","count":2}]},{"hash":"1777045014969466812","title":"RNA Processing and Ribosome Biogenesis","description":"This cluster is dominated by RNA-centric processes, with mRNA splicing via spliceosome and ribosome biogenesis each appearing most frequently (6). Those two terms point to core RNA processing and ribosome assembly roles. The presence of additional terms related to development and signaling, while informative, appears more peripheral or pleiotropic, suggesting the core theme centers on RNA biology rather than a single developmental pathway. Confidence: Medium","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000398","count":6},{"id":"GO:0006890","count":6},{"id":"GO:0042254","count":6},{"id":"GO:0021510","count":5},{"id":"GO:0071560","count":5}]},{"hash":"1116689267130084797","title":"Endocytic-immune membrane signaling","description":"This cluster shows strong links to endocytosis and membrane-associated processes (phospholipid homeostasis, cell polarity) along with immune signaling terms (T-helper 1 response, interferon production) and related stress signaling (JNK cascade) as well as xenobiotic response. The common theme appears to be proteins involved in membrane signaling that modulate immune responses and trafficking, rather than a single narrowly defined function.","confidence":"Medium","size":16,"edges":79,"triangles":169,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010628","count":12},{"id":"GO:0055091","count":12},{"id":"GO:0006897","count":9},{"id":"GO:0071260","count":9},{"id":"GO:0032729","count":9}]},{"hash":"1548998593696209976","title":"Th1 cytokine signaling and IL-1 regulation","description":"This cluster is dominated by immune signaling terms: Th1-type immune response, IFN-\u03b3 (type II interferon) production, negative regulation of IL-1 signaling, and STAT phosphorylation, along with PI3K-AKT signaling and cytokine/chemokine production (MCP-1). These collectively indicate a module focused on Th1 cytokine signaling and inflammatory regulation.","confidence":"High","size":16,"edges":28,"triangles":6,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:2000660","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0032729","count":3},{"id":"GO:0042517","count":3},{"id":"GO:0071639","count":3}]},{"hash":"203102012616800302","title":"Cytokine signaling and leukocyte recruitment","description":"This cluster\u2019s top GO terms converge on inflammatory signaling pathways (NF-kappaB, STAT phosphorylation, MAPK, IL-1 signaling) and leukocyte trafficking (monocyte chemoattractant protein-1 production, neutrophil extravasation), suggesting a core function in immune signaling and recruitment. Some terms also touch on development (heart) and neuronal localization, indicating broader roles in signaling during tissue remodeling, but the strongest signal centers on immune response and cell movement. ","confidence":"Medium","size":16,"edges":29,"triangles":6,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035234","count":4},{"id":"GO:0042517","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0002175","count":4}]},{"hash":"1490185937007350482","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":15,"triangles":0,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":3},{"id":"GO:0097171","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0016310","count":2},{"id":"GO:0019350","count":2}]},{"hash":"2272527970932863773","title":"Adaptive immune signaling and antibody production","description":"The top GO terms center on adaptive immunity: B cell receptor signaling, immunoglobulin production, negative regulation of T cell proliferation, CD8 T cell apoptotic processes, and IL-10\u2013related regulation, with an accompanying innate immune response and cell\u2013cell adhesion. This pattern suggests a coherent cluster of proteins involved in antibody-mediated signaling and regulation of adaptive immune responses, despite a few unrelated terms that may reflect annotation noise.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":7},{"id":"GO:0045087","count":6},{"id":"GO:0010765","count":6},{"id":"GO:0050853","count":6},{"id":"GO:0043031","count":6}]},{"hash":"411990609326054051","title":"Neural Sensory Signaling and Thermoregulation","description":"The top GO terms are centered on neural sensory processing and temperature-related responses (pain perception, thermogenesis, cellular response to temperature), along with signaling cascades (ERK, adenylate cyclase) and neural-influenced behaviors (cocaine response, visual learning). Although there are a few cardiovascular/development terms present, the dominant theme across the cluster is neural sensing and signaling coupled with thermoregulation, making this a concise, representative label.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0002024","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0007507","count":8},{"id":"GO:0007190","count":8}]},{"hash":"2190414242898217682","title":"Axon guidance and paranodal junction assembly","description":"The top GO terms cluster around axon extension and precise localization to paranodal/juxtaparanodal regions, plus paranodal junction assembly, suggesting a group of proteins focused on axon domain organization and neural connectivity. Supporting terms for synaptic vesicle endocytosis and broader neural development align but do not overwhelm the central theme.","confidence":"High","size":16,"edges":7,"triangles":0,"max_degree":5,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0048846","count":8},{"id":"GO:0071205","count":8},{"id":"GO:0002175","count":8},{"id":"GO:0030913","count":8},{"id":"GO:0060982","count":8}]},{"hash":"407118550182541570","title":"Unknown","description":"The top terms include acrosome reaction and egg activation (reproduction), B cell differentiation (immune), brain development and GABAergic synaptic regulation (neural), plus signaling pathways like phosphatidylinositol-mediated and Rho signaling. This wide mix suggests multiple tissue-specific roles with no single cohesive function linking all proteins, so a unified label isn\u2019t reliable.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:1900122","count":3},{"id":"GO:0007343","count":3},{"id":"GO:0048015","count":3},{"id":"GO:0007340","count":3},{"id":"GO:0016525","count":3}]},{"hash":"1857217862585929488","title":"Neuronal adhesion and synapse formation","description":"Based on the prominent GO terms, the cluster centers on neural connectivity and synapse biology, including homophilic/heterophilic cell adhesion, nervous system development, synapse assembly (and its regulation), and nerve maturation, with ROBO signaling guiding axon paths. A single outlier term about symbiont entry into host cells likely represents annotation noise rather than a core function. ","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007156","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0007157","count":8},{"id":"GO:0051965","count":7},{"id":"GO:0007155","count":7}]},{"hash":"324001178327803031","title":"Ubiquitination and Protein Degradation","description":"The cluster is dominated by ubiquitin-related processes: ubiquitin-dependent protein catabolic process, protein ubiquitination, K48- and K6-linked ubiquitination, autoubiquitination, and histone ubiquitination, indicating involvement in the ubiquitin-proteasome system and chromatin turnover. The presence of adaptive immune response and TNF signaling regulation terms suggests roles in ubiquitin-regulated immune signaling pathways as well.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:1903265","count":8},{"id":"GO:0070936","count":8},{"id":"GO:0016567","count":8},{"id":"GO:0051865","count":7}]},{"hash":"778442541377435190","title":"Innate antiviral immune response","description":"The cluster is dominated by GO terms for defense against virus and innate immunity, with supporting terms in inflammatory signaling (IL-17 pathway, chemokine production), apoptosis regulation, and ubiquitin-dependent proteolysis. Together these reflect core innate antiviral defense and immune-regulatory processes, despite some peripheral terms related to epigenetic regulation and cytoskeletal dynamics. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051607","count":10},{"id":"GO:0045087","count":10},{"id":"GO:0042787","count":9},{"id":"GO:0007026","count":8},{"id":"GO:1903886","count":6}]},{"hash":"1894186704477788305","title":"Immune signaling and tissue development","description":"The set shows enrichment in innate immune processes (positive regulation of eosinophil degranulation; positive regulation of neutrophil killing of Gram-negative bacteria; dendritic cell chemotaxis; response to lipopolysaccharide), indicating immune activation. In addition, terms like lung connective tissue development, retina development, and heart development point to tissue/organ development roles. The combination suggests these proteins participate in immune signaling with links to tissue development or remodeling, rather than a single, cohesive pathway. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":13},{"id":"GO:0060427","count":13},{"id":"GO:0070963","count":13},{"id":"GO:0051482","count":13},{"id":"GO:0060041","count":13}]},{"hash":"39183668289880199","title":"GPCR-mediated neuroimmune signaling and vascular regulation","description":"This cluster is dominated by GO terms for GPCR signaling and neuropeptide signaling (e.g., adenylate cyclase-activating GPCR signaling, neuropeptide signaling, pain perception), along with terms related to immune cell activation and degranulation (eosinophils, neutrophils). There are also vascular-related terms (blood pressure regulation) and lung/connective tissue development, suggesting a recurring theme of signaling pathways that coordinate neural, immune, and vascular functions. While an electron transport chain term appears, the overall pattern points to signaling-driven modulation of neuroimmune and vascular processes rather than metabolism. Confidence: Medium","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":10},{"id":"GO:0022900","count":10},{"id":"GO:0010579","count":10},{"id":"GO:0035025","count":9},{"id":"GO:0019233","count":9}]},{"hash":"2219934075047255037","title":"Unknown","description":"The terms span diverse biological processes\u2014from cell division and ribosome biogenesis to neuron projection development and eye morphogenesis\u2014without a single coherent theme or shared function binding the proteins. With no edges connecting members, a specific, representative label cannot be confidently assigned.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0000278","count":2},{"id":"GO:0000747","count":2}]},{"hash":"2093701728005384969","title":"Proteostasis and heat-stress response","description":"This cluster centers on protein quality control and stress responses, with GO terms spanning unfolded/misfolded protein handling, ubiquitin-proteasome\u2013mediated quality control (including nuclear QC), and responses to heat. The combination of unfolded/misfolded protein signaling, heat response, and targeted protein degradation suggests a cohesive proteostasis/heating stress function rather than a singular signaling or metabolic process.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006469","count":7},{"id":"GO:0032781","count":6},{"id":"GO:1900035","count":6},{"id":"GO:0009408","count":6},{"id":"GO:0006452","count":6}]},{"hash":"1945428853855076788","title":"Inflammation and organogenesis","description":"This cluster shows strong enrichment for innate immune/inflammatory processes (response to LPS, dendritic cell chemotaxis, eosinophil and neutrophil activity) together with organ development terms (lung connective tissue development, heart development, retina development, endothelial barrier regulation). The mix suggests proteins involved in inflammatory responses that intersect with developmental and vascular processes across tissues, supporting an \u201cinflammation and organogenesis\u201d theme.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":16},{"id":"GO:0060427","count":16},{"id":"GO:0070963","count":16},{"id":"GO:0051482","count":16},{"id":"GO:0060041","count":16}]},{"hash":"479250451756342885","title":"Wnt-Hippo Signaling and Angiogenesis","description":"The top GO terms cluster around growth-regulating signaling pathways (canonical Wnt and Hippo), with associated processes in proliferation control, differentiation (keratinocyte differentiation), apoptosis, and angiogenesis. This points to a group of proteins coordinating tissue growth, cell fate decisions, and vascular development rather than a single linear function, justifying a concise label that captures these interconnected pathways.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060044","count":14},{"id":"GO:0030216","count":14},{"id":"GO:0090263","count":14},{"id":"GO:0006915","count":14},{"id":"GO:0035329","count":14}]},{"hash":"1271195582577677623","title":"Developmental morphogenesis and cell fate","description":"This cluster's top GO terms predominantly relate to embryonic tissue morphogenesis across various organs (cardiogenic plate, bile duct, lung, digestive tract) and to cell fate specification and developmental progression, suggesting a coordinated developmental and differentiation program rather than a single signaling pathway.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":1},{"id":"GO:0003142","count":1},{"id":"GO:0035622","count":1},{"id":"GO:0061145","count":1},{"id":"GO:0048557","count":1}]},{"hash":"2071795856209535932","title":"Immune activation and antigen presentation","description":"The cluster\u2019s GO terms center on immune system function: innate and adaptive immunity, cytokine production (including IL-10), T cell costimulation, immunoglobulin production, and MHC class II\u2013mediated antigen processing and presentation. There\u2019s additional support from terms like response to peptidoglycan and innate immune response, pointing to broader immune signaling. A few development terms appear but do not define the core theme; overall the dominant signal is immune activation and antigen presentation.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:2001181","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0002377","count":3},{"id":"GO:0002374","count":3}]},{"hash":"669783203943667508","title":"Microtubule nucleation and spindle assembly","description":"The top GO terms point to microtubule nucleation and spindle organization across both mitotic and meiotic contexts, including meiotic cell cycle and spindle assembly in meiosis II, as well as microtubule-dependent localization (e.g., bicoid mRNA). This suggests the cluster mainly reflects cytoskeletal dynamics governing microtubule nucleation and spindle formation, with some peripheral signaling terms likely reflecting additional functions or annotations. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038095","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0048666","count":2},{"id":"GO:0038109","count":2},{"id":"GO:0007058","count":2}]},{"hash":"483211862700265362","title":"Mechanosensory and Pain Signaling","description":"The top terms cluster around responses to mechanical stimulus and pain perception, with supporting signals for calcium ion import and actin cytoskeleton dynamics, suggesting a mechanotransduction-focused module. Some terms (NOD2 signaling, vitamin D response, endothelial differentiation) are less central but may reflect broader signaling roles within these proteins. Overall, the cluster centers on mechanical sensation and downstream signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":6},{"id":"GO:0050966","count":5},{"id":"GO:0070431","count":4},{"id":"GO:0060843","count":4},{"id":"GO:1900827","count":4}]},{"hash":"986126099619285946","title":"Sphingolipid and fatty acid biosynthesis","description":"This cluster is enriched with terms for fatty acid response, monounsaturated fatty acid biosynthesis, and sphingolipid metabolism (sphingosine and sphinganine), plus adipocyte differentiation. The convergence on lipid biosynthesis and sphingolipid pathways suggests a cohesive lipid metabolism module, with possible relevance to skin barrier lipids and adipogenesis; a few terms appear tangential (e.g., tarsal gland development), but the core signal points to lipid biosynthetic processes.","confidence":"High","size":15,"edges":28,"triangles":20,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":4},{"id":"GO:0050872","count":4},{"id":"GO:1903699","count":3},{"id":"GO:1903966","count":3},{"id":"GO:0010873","count":3}]},{"hash":"362182552785654779","title":"Quinone biosynthesis and fatty acid metabolism","description":"The cluster shows strong representation of quinone-related biosynthesis (menaquinone and phylloquinone), fatty acid beta-oxidation, and various catabolic pathways (valine, phenylacetate), with some antibiotic biosynthesis as a secondary metabolism signal. This points to a cohesive microbial energy and lipid/quinone metabolism module rather than random associations.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006574","count":15},{"id":"GO:0009234","count":15},{"id":"GO:0010124","count":15},{"id":"GO:0042372","count":15},{"id":"GO:0006635","count":15}]},{"hash":"701433104450854440","title":"Embryonic organogenesis and neural differentiation","description":"These terms cluster around developmental processes across multiple tissues. Neural development is prominent (cerebral cortex regionalization, ventral spinal cord interneuron specification, dopaminergic neuron differentiation), alongside skeletal/cartilage formation, kidney tubule morphogenesis, and lymph vessel morphogenesis, all pointing to broad embryonic organogenesis and tissue differentiation rather than a single pathway.","confidence":"Medium","size":15,"edges":11,"triangles":0,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0021796","count":3},{"id":"GO:0021521","count":3},{"id":"GO:0048706","count":3},{"id":"GO:0071542","count":3}]},{"hash":"1300888874296673666","title":"Embryonic Development and Morphogenesis","description":"This cluster is enriched in GO terms for development across several organs (midbrain, pancreas, digestive tract, neural crest, ureteric bud morphogenesis) and includes chromatin remodeling and transcriptional regulation, suggesting proteins that coordinate epigenetic control during embryogenesis and organ formation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0030901","count":4},{"id":"GO:0031018","count":4},{"id":"GO:0071560","count":3},{"id":"GO:0048557","count":3}]},{"hash":"1918674622856686261","title":"Vertebrate Organ Development","description":"The cluster centers on developmental processes across multiple vertebrate organs (placenta, pancreas, cerebral cortex, inner ear, gonadal mesoderm, endothelial barrier) with accompanying transcriptional regulation terms, suggesting a broad role in organogenesis and gene expression during development. Some terms (oxidant detoxification, locomotory behavior) are more general or peripheral but do not override the common developmental theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0006351","count":2},{"id":"GO:0001890","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0031016","count":2}]},{"hash":"1256361708047947969","title":"Deubiquitinases modulating NF-\u03baB and cytokine signaling","description":"The cluster is enriched for ubiquitination and deubiquitination terms, including K27-, K33-, and K63-linked deubiquitination, along with negative regulation of canonical NF-kappaB signaling and cytokine production (IL-2, IL-1\u03b2) and CD40 signaling. This points to DUBs that edit ubiquitin chains to dampen immune signaling, i.e., negative regulators of NF-\u03baB and cytokine pathways; a few terms about NOD-like receptor signaling support this theme, while an unrelated locomotory behavior term is likely incidental.","confidence":"Medium","size":15,"edges":26,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043124","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0035641","count":2},{"id":"GO:0032703","count":1},{"id":"GO:1990168","count":1}]},{"hash":"481791570843423691","title":"Vesicle-Mediated Signaling and Growth Factor Pathways","description":"The terms converge on vesicle-mediated signaling: vesicle priming and acrosome reaction hint at Ca2+-dependent exocytosis; chemical synaptic transmission and acetylcholine GPCR signaling point to neural signaling; and IGF/EGF signaling along with angiogenesis and vascular remodeling place this in growth-factor\u2013driven vascular contexts. Together these terms suggest a theme of vesicle-driven signal transduction across neural, reproductive, and vascular systems.","confidence":"Medium","size":15,"edges":16,"triangles":2,"max_degree":14,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0001525","count":5},{"id":"GO:0007268","count":5},{"id":"GO:0007340","count":5},{"id":"GO:0006911","count":4},{"id":"GO:0007213","count":4}]},{"hash":"554634168979702968","title":"Ubiquitin-regulated mitotic progression","description":"The terms show strong enrichment for mitotic processes (G2/M transition, chromosome segregation, exit from mitosis) and ubiquitin-dependent regulation (SCF-dependent proteasomal degradation, K11-linked ubiquitination), indicating a cluster of proteins that control mitosis through targeted degradation. Although viral process and embryonic development terms appear, the core theme is ubiquitin-mediated control of the cell cycle, especially mitotic progression and spindle-checkpoint regulation.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0000086","count":15},{"id":"GO:0031146","count":15},{"id":"GO:0016032","count":14},{"id":"GO:0007059","count":14},{"id":"GO:0070911","count":14}]},{"hash":"2065298425760269036","title":"Organelle Protein Import and Membrane Insertion","description":"The top GO terms are dominated by protein import into mitochondrial matrix and chloroplast stroma, as well as protein insertion into the mitochondrial inner membrane, pointing to a shared role in targeting and integrating proteins into organelle membranes. Some lipid-regulation terms appear secondary and less cohesive with the main theme. Therefore, a label centered on organelle protein import and membrane insertion best captures the cluster's core function.","confidence":"Medium","size":15,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":3},{"id":"GO:0000002","count":2},{"id":"GO:0032094","count":2},{"id":"GO:0045039","count":2},{"id":"GO:0045037","count":2}]},{"hash":"1728237502605653081","title":"Translation Control and Initiation/Elongation","description":"Most terms point to translation and its regulation, including initiation, elongation, termination, and frameshifting, plus hypusination of eIF5A which is essential for elongation. GTPase activity regulation supports ribosome-associated factors. A couple of terms (heart development, defense-related PCD) may reflect broader annotations or cross-species signals, but the dominant theme is protein synthesis machinery and its control.","confidence":"Medium","size":15,"edges":10,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0034050","count":3},{"id":"GO:0006412","count":3},{"id":"GO:1903272","count":3}]},{"hash":"329526083904638472","title":"Immune signaling and MAPK regulation","description":"The proteins are enriched for immune-related terms (LPS response, Th1-type immune response, negative regulation of IL-23) and for regulation of MAPK pathways (JNK and ERK cascades), plus dendritic cell migration, suggesting a function in inflammatory signaling and immune cell communication modulated by MAPK signaling. Some developmental terms (hippocampus development, hair follicle morphogenesis) may reflect broader or pleiotropic roles. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":5},{"id":"GO:0032707","count":5},{"id":"GO:0042088","count":5},{"id":"GO:0046330","count":5},{"id":"GO:0021766","count":4}]},{"hash":"1221173507967455105","title":"Developmental morphogenesis and signaling","description":"This cluster shows a broad enrichment for developmental processes across multiple tissues (forebrain development, haltere morphogenesis, anterior head development, paramesonephric duct development) and associated signaling pathways (integrin signaling, B cell receptor signaling, G-CSF production). The presence of actin filament bundle assembly also ties in to cytoskeletal remodeling required for morphogenesis. Together, these terms suggest a cohesion around developmental regulation and morphogenesis rather than a single, specific function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021937","count":11},{"id":"GO:0008585","count":11},{"id":"GO:0050859","count":11},{"id":"GO:0071657","count":11},{"id":"GO:2000744","count":11}]},{"hash":"2221206771002655882","title":"Dopaminergic Visual and Sensory Signaling","description":"The cluster shows a strong emphasis on nervous system signaling and sensory processing, with terms for visual perception and learning, dopaminergic synaptic transmission, pain perception, and behavioral responses to cocaine. ERK1/ERK2 cascade regulation and protein phosphorylation indicate active signal transduction, while prostaglandin-related responses and macrophage chemotaxis suggest broader neuromodulatory signaling contexts. Although \"heart development\" appears among terms, the dominant pattern points to neural communication and sensory pathways.","confidence":"Medium","size":15,"edges":102,"triangles":417,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":14},{"id":"GO:0008542","count":13},{"id":"GO:0070374","count":13},{"id":"GO:0019233","count":13},{"id":"GO:0071380","count":13}]},{"hash":"232844680188123825","title":"Immune signaling and lymphocyte regulation","description":"This cluster centers on cytokine and immune signaling pathways, including TGF-beta responses, JAK-STAT signaling (growth hormone receptor pathway via JAK-STAT), and regulatory effects on B cell and monocyte/dendritic cell differentiation, plus NK T cell differentiation and innate responses to fungal origin molecules. The mix suggests a coordinated immune signaling module rather than a single metabolic pathway.","confidence":"High","size":15,"edges":32,"triangles":25,"max_degree":8,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0071226","count":15},{"id":"GO:0009395","count":14},{"id":"GO:0061847","count":14},{"id":"GO:0071560","count":14},{"id":"GO:0014911","count":14}]},{"hash":"2260831254416787893","title":"ER stress response and cell-cycle processes","description":"The GO terms are dominated by endoplasmic reticulum unfolded protein response and ER-associated degradation, with multiple entries for cell division/mitosis, alongside development and host interaction terms. This suggests a cluster centered on ER stress/protein quality control with associated growth and division processes, rather than a single specific function.","confidence":"Medium","size":15,"edges":13,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0030968","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0016032","count":3},{"id":"GO:0000027","count":2}]},{"hash":"1467617489546966835","title":"Ubiquitin-Driven Proteolysis and Innate Immunity","description":"Explanation: It combines ubiquitin-dependent degradation (K48, K63, autoubiquitination, ERAD) with innate immune signaling (NF-\u03baB, TNF, antiviral defense), suggesting a functional cluster of ubiquitin modifiers/regulators linking proteostasis to antiviral immunity.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0070936","count":6},{"id":"GO:0051865","count":5},{"id":"GO:0043123","count":5},{"id":"GO:0070534","count":5}]},{"hash":"538171369604469939","title":"Developmental transcription and differentiation","description":"These proteins cluster around DNA-templated transcription and a range of differentiation processes across multiple tissues (fat cells, mammary gland, placenta, face, Leydig cells), plus retinoic acid\u2013related signaling. The common theme is regulation of gene expression during development and organ differentiation, rather than a single tissue-specific function, suggesting a developmental/transcriptional regulatory module.","confidence":"Medium","size":15,"edges":14,"triangles":1,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:2001275","count":8},{"id":"GO:0045444","count":8},{"id":"GO:0033327","count":7},{"id":"GO:0060749","count":7}]},{"hash":"1032102719753798607","title":"Mitochondrial energy transport and insulin signaling","description":"The dominant terms center on mitochondrial processes\u2014ATP/ADP transport, membrane potential regulation, and mitochondrial fission\u2014and on insulin-related responses (insulin stimulus, regulation of insulin secretion) in the context of glucose. Additional terms for iron and phosphate transport into mitochondria further support a theme of mitochondrial energy metabolism linked to insulin signaling and nutrient sensing. Confidence: High","confidence":"High","size":15,"edges":33,"triangles":4,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0061179","count":7},{"id":"GO:0048250","count":6},{"id":"GO:0035435","count":6},{"id":"GO:0015866","count":6},{"id":"GO:0090149","count":6}]},{"hash":"1666783712923883859","title":"Synaptic plasticity and receptor trafficking","description":"This cluster centers on neuronal signaling and synaptic modulation, driven by terms like regulation of long-term neuronal synaptic plasticity, excitatory postsynaptic potential, receptor internalization, and GTPase/Rho signaling. While some terms relate to development or behavior (ethanol response, phototaxis, lateral line development), the dominant theme ties receptor dynamics and cytoskeletal signaling to synaptic strength and dendrite development. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048169","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0031623","count":3},{"id":"GO:0007168","count":3},{"id":"GO:0060079","count":3}]},{"hash":"999594480077012053","title":"Innate to Adaptive Immune Activation","description":"The GO terms cluster around immune system processes, including phagocytosis and innate response, complement activation, interferon signaling, antigen processing and presentation, and B cell receptor signaling/activation, indicating a bridge between innate recognition and adaptive immune activation.","confidence":"High","size":15,"edges":61,"triangles":90,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006911","count":8},{"id":"GO:0006910","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0050853","count":8},{"id":"GO:0050871","count":8}]},{"hash":"439743766334376709","title":"Unknown","description":"The terms span heart development, vision, pain perception, cocaine response, blood pressure regulation, GPCR and ERK signaling, macrophage chemotaxis, and electron transport\u2014covering development, sensory, signaling, immunity, and metabolism. There isn\u2019t a single dominant function tying these together, so a cohesive, specific label isn\u2019t evident.","confidence":"","size":15,"edges":21,"triangles":0,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":13},{"id":"GO:0070374","count":13},{"id":"GO:0048148","count":13},{"id":"GO:0010759","count":13},{"id":"GO:0019233","count":13}]},{"hash":"346032976035915751","title":"Organ development and innate immune response","description":"The top GO terms point to tissue and organ development (lung connective tissue, heart, retina, endothelial barrier regulation) along with innate immune activities (eosinophil and neutrophil functions, dendritic cell chemotaxis, response to LPS). This suggests a loose but coherent theme where proteins participate in both developmental processes and early immune/inflammatory signaling, possibly at vascular or mucosal interfaces. Given the sparse connectivity (one edge, no triangles), the association is plausible but not tightly connected.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":14},{"id":"GO:0060427","count":14},{"id":"GO:0070963","count":14},{"id":"GO:0051482","count":14},{"id":"GO:0060041","count":14}]},{"hash":"27899192660313464","title":"Immune Activation and Vascular Development","description":"The top GO terms show immune-related activity (eosinophil degranulation, dendritic cell chemotaxis, neutrophil killing, LPS response) alongside tissue development and vascular regulation (lung connective tissue, heart, retina development, endothelial barrier modulation). This points to a core theme of inflammatory signaling coupled with tissue remodeling and vascular processes, making \"Immune Activation and Vascular Development\" a coherent label.","confidence":"Medium","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":10},{"id":"GO:0060427","count":10},{"id":"GO:0070963","count":10},{"id":"GO:0051482","count":10},{"id":"GO:0060041","count":10}]},{"hash":"1897753032244284992","title":"T cell\u2013mediated inflammation and NF-kappaB signaling","description":"This cluster centers on immune-related processes: inflammatory response, T cell proliferation, and activation of canonical NF-kappaB signaling, with accompanying transcriptional regulation, vitamin D response, and spleen-associated development terms. The convergence of these GO terms supports a cohesive module of T cell\u2013driven inflammatory signaling and NF-\u03baB pathway activity, reflecting immune activation and related gene expression programs.","confidence":"High","size":15,"edges":22,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0010467","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0071157","count":2},{"id":"GO:0042098","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1142927815158563157","title":"Calcium signaling and estrogen response","description":"The top GO terms point to calcium-release channel regulation and calcium release from the sarcoplasmic/endoplasmic reticulum, plus estrogen response activity, with supporting tissue-context terms for retina/eye and reproductive organs. This suggests a cohesive theme around calcium signaling machinery integrated with estrogen-responsive signaling across neural/visual and reproductive tissues.","confidence":"Medium","size":15,"edges":14,"triangles":12,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0061298","count":3},{"id":"GO:0030879","count":3},{"id":"GO:0060065","count":3},{"id":"GO:0060315","count":3},{"id":"GO:0060316","count":3}]},{"hash":"1635089832910199336","title":"Bacterial fatty acid and menaquinone biosynthesis","description":"These terms cluster around bacterial lipid metabolism and cell envelope biosynthesis, including fatty acid metabolism across chain lengths, fatty-acyl-CoA metabolism, lipoteichoic acid biosynthesis, and menaquinone biosynthesis. Together they point to membrane lipid production and energy-related quinone synthesis typical of Gram-positive bacteria, with a few ancillary aromatic compound catabolic terms. ","confidence":"High","size":15,"edges":81,"triangles":228,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":9},{"id":"GO:0001676","count":9},{"id":"GO:0090410","count":9},{"id":"GO:0001579","count":9},{"id":"GO:0070395","count":9}]},{"hash":"157218996923194845","title":"Neural Development and Eye Morphogenesis with Lipid Homeostasis","description":"The terms cluster around nervous system development, neurogenesis, forebrain proliferation, and embryonic retina morphogenesis, pointing to a core role in neural/eye development and neuronal survival (apoptosis regulation). Additional signals for xenobiotic response and gene expression regulation suggest developmental transcriptional control and stress response, while lipid homeostasis and white fat differentiation indicate accompanying metabolic regulation. Overall, the proteins appear linked to neural/eye development with concurrent lipid metabolic processes.","confidence":"High","size":15,"edges":89,"triangles":288,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":7},{"id":"GO:0043524","count":5},{"id":"GO:0050872","count":4},{"id":"GO:0010628","count":4},{"id":"GO:0042493","count":4}]},{"hash":"1737017414958188933","title":"Neural development and immune signaling","description":"This cluster is dominated by terms tied to nervous system development, retina morphogenesis, and forebrain cell proliferation, pointing to neural development as the core function. The presence of cytokine signaling terms (IL-27 pathway, Th2 cytokine production, STAT phosphorylation) and phospholipid homeostasis suggests accompanying signaling interactions that can influence development, hence a label that encompasses both neural development and immune-related signaling.","confidence":"Medium","size":15,"edges":102,"triangles":416,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":3},{"id":"GO:0010628","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0055091","count":3},{"id":"GO:0042517","count":3}]},{"hash":"1334370832635957781","title":"Cardiac calcium signaling and heart development","description":"The terms cluster around calcium-regulated control of cardiac contraction (calcium release, calcium transport), heart rate regulation, and heart development, with related pathways such as the calcium-modulating Wnt pathway and adenylate cyclase signaling. Additional terms on potassium channel clustering and EMT reflect cardiac electrophysiology and developmental remodeling. Together, they point to calcium-driven cardiac signaling and development.","confidence":"High","size":15,"edges":91,"triangles":332,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010881","count":15},{"id":"GO:0001975","count":15},{"id":"GO:0002027","count":15},{"id":"GO:1905205","count":15},{"id":"GO:0007223","count":15}]},{"hash":"594325618164459220","title":"Myoblast fusion and membrane remodeling","description":"This cluster is anchored by myoblast fusion and synapse assembly signals, with supporting patterns in cytoskeletal remodeling (Rho signaling), endocytosis regulation, and lipid metabolism (phospholipid/sphingolipid biosynthesis, dolichyl phosphate), all pointing to coordinated membrane remodeling during muscle development and neuromuscular junction formation.","confidence":"Medium","size":15,"edges":88,"triangles":281,"max_degree":14,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007520","count":7},{"id":"GO:0035023","count":7},{"id":"GO:0007416","count":6},{"id":"GO:0048260","count":6},{"id":"GO:0034517","count":6}]},{"hash":"1151186791596420428","title":"Endosomal trafficking and secretory vesicle maturation","description":"The top GO terms cluster around intracellular/protein transport via endosomal pathways (endosome-to-lysosome, early-to-late endosome, intralumenal vesicle formation) and Golgi retention, plus dense core granule maturation and PI-mediated signaling, all pointing to vesicle trafficking in the secretory/endosomal system. This cohesive theme suggests the proteins function together in endosomal sorting and vesicle maturation pathways, despite the lack of explicit protein interaction edges in this cluster.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":3},{"id":"GO:0001778","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0045022","count":2},{"id":"GO:0010796","count":2}]},{"hash":"225696789852220981","title":"Mitosis and actin remodeling with vesicle trafficking","description":"The cluster is dominated by mitosis-related terms (mitotic cell cycle, mitotic spindle assembly, cell division) and cytoskeletal dynamics (actin filament depolymerization, Arp2/3 regulation), complemented by membrane trafficking processes (COPII vesicle budding, Golgi-to-ER transport) and RNA transport, suggesting coordinated roles in cell division with actin remodeling and vesicle trafficking.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0090307","count":3},{"id":"GO:0030042","count":3},{"id":"GO:0034316","count":2},{"id":"GO:0071456","count":2}]},{"hash":"722289536760707602","title":"Ubiquitination and Histone Regulation","description":"The top GO terms are dominated by ubiquitin-related processes (ubiquitin-dependent proteolysis, polyubiquitination) and several histone modification links (histone catabolic process, histone ubiquitination, histone acetylation/methylation regulation). This suggests a cluster of proteins centered on ubiquitin signaling that governs protein turnover and chromatin state, with some host-viral interaction context. Confidence: High","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0000209","count":7},{"id":"GO:1901253","count":6},{"id":"GO:0070535","count":5},{"id":"GO:2000620","count":5}]},{"hash":"2259313178214203387","title":"Embryogenesis and organ morphogenesis","description":"The top GO terms cluster around developmental and organ-forming processes across multiple tissues (in utero embryonic development, left/right patterning, midbrain and eye morphogenesis, pancreas morphogenesis, cardiac muscle proliferation, and overall multicellular growth), with one regulatory transcription term adding a general gene-expression control aspect. This points to a cohesive theme of embryonic development and organ morphogenesis rather than a single specific pathway.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0030901","count":4},{"id":"GO:0001701","count":3},{"id":"GO:0060038","count":3},{"id":"GO:0061113","count":3}]},{"hash":"2289867654739974359","title":"Placental development and embryonic morphogenesis","description":"Proteins in this cluster are strongly linked to embryonic development and morphogenesis, especially placental/trophoblast differentiation (GO:0060707) and related processes like EMT in heart/junction formation (GO:0003198) and cartilage morphogenesis (GO:0060536). The presence of left-right patterning (GO:0060972) and endocrine system development (GO:0035270) signals a broader developmental program, but the dominant theme is placental and embryonic tissue formation, supporting a label around placental development and embryonic morphogenesis.","confidence":"High","size":15,"edges":8,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":9},{"id":"GO:0003198","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0060972","count":6}]},{"hash":"1090232088464725847","title":"Transcription control and tissue remodeling with innate immunity","description":"This cluster combines GO terms tied to RNA polymerase II transcription regulation (both negative and positive regulation) with extracellular matrix disassembly and tissue remodeling, alongside innate immune responses (complement lectin pathway, defense against fungus and Gram-positive bacteria) and coagulation. The common thread appears to be a cross-talk between transcriptional regulation, structural remodeling of the extracellular matrix, and immune/coagulation signaling, suggesting a coordinated response in tissue remodeling and defense. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0045944","count":7},{"id":"GO:0022617","count":5},{"id":"GO:1902947","count":5},{"id":"GO:0048771","count":5}]},{"hash":"1645276913353639310","title":"Blood Coagulation and ECM Remodeling","description":"This cluster shows strong signals for blood coagulation and complement activation, along with collagen catabolism, extracellular matrix disassembly, and tissue remodeling including angiogenesis. The recurring theme is clotting-associated processes coupled with remodeling of the extracellular matrix, typical of wound healing and vascular remodeling, rather than a single narrow function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":7},{"id":"GO:0006958","count":6},{"id":"GO:0030574","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0035264","count":5}]},{"hash":"1592723805086686538","title":"Neurovascular development signaling","description":"The terms cluster around neural development (Purkinje cell layer development, synapse maturation, axon guidance) and vascular growth signaling (VEGF and PDGF receptor pathways, sprouting angiogenesis). The overlap suggests proteins participate in coordinated neurovascular development and signaling networks, with a few outliers not altering the core theme.","confidence":"High","size":15,"edges":7,"triangles":2,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001501","count":9},{"id":"GO:0090036","count":9},{"id":"GO:0048010","count":9},{"id":"GO:0007338","count":9},{"id":"GO:0021680","count":9}]},{"hash":"39549953737853940","title":"Embryonic mesoderm and craniofacial development","description":"The top GO terms cluster around embryonic tissue formation: mesoderm development, cartilage morphogenesis, roof of mouth development, endocardial cushion EMT (heart development), and placental lineages (trophoblast differentiation and placental development). Additional terms on transcription regulation and replication initiation likely reflect broader developmental gene regulation rather than core metabolism. Together these suggest a developmental program focused on mesodermal/craniofacial and placental differentiation.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":14},{"id":"GO:0000122","count":13},{"id":"GO:0006366","count":10},{"id":"GO:0003198","count":9},{"id":"GO:0060707","count":9}]},{"hash":"364716728973013338","title":"Hedgehog-Linked Immune Regulation","description":"The enriched GO terms point to development-related Hedgehog signaling (smoothened pathway) coupled with immune modulation, including neutrophil trafficking, regulation of macrophage activation, IL-10 production, T cell activity, and NK cell cytotoxicity. This suggests a cluster of proteins that integrate developmental signaling with leukocyte regulation, with additional developmental processes that align with Hedgehog's broad roles.","confidence":"Medium","size":15,"edges":17,"triangles":3,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070166","count":5},{"id":"GO:0007224","count":5},{"id":"GO:0072672","count":5},{"id":"GO:0007411","count":5},{"id":"GO:0043031","count":5}]},{"hash":"921068071370730536","title":"Ubiquitination in NF-kB and Immune Signaling","description":"The terms are dominated by ubiquitin-dependent protein catabolic processes and various types of ubiquitination (polyubiquitination, autoubiquitination, K63-linked), with several immune-related pathways (TNF signaling, adaptive immune response, NF-kB regulation). This suggests a cohesive theme of ubiquitin-mediated regulation affecting immune signaling, including NF-kB activity.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0000209","count":6},{"id":"GO:0051865","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0007275","count":5}]},{"hash":"796156000639745342","title":"Ubiquitin-Dependent NF-kappaB Signaling (TNF)","description":"The cluster is enriched for ubiquitin-dependent protein catabolic process along with TNF- and NF-kappaB-related signaling terms, including activation of NF-kappaB-inducing kinase, pointing to a shared role in ubiquitin-mediated regulation of inflammatory signaling rather than a structural or metabolic function. Some obsolete histone modification terms appear likely to reflect annotation noise.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0042981","count":7},{"id":"GO:0070512","count":7},{"id":"GO:0070535","count":7},{"id":"GO:2000620","count":7}]},{"hash":"172482568569226094","title":"Neurodevelopmental Signaling and Mechanotransduction","description":"The top GO terms center on neuronal development and synaptic plasticity (positive regulation of neuron projection development, long-term synaptic potentiation) and mechanotransduction (cellular response to mechanical stimulus) with associated signaling pathways (Wnt regulation). While there are also terms related to apoptosis, ECM organization, and innate immunity, the strongest, coherent theme across the cluster is neural development and mechanical signaling pathways.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010976","count":4},{"id":"GO:0060291","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0071260","count":3},{"id":"GO:0090263","count":3}]},{"hash":"1682751113043727525","title":"Epithelial Growth Signaling (Wnt/Hippo)","description":"Dominant terms point to epithelial cell processes (keratinocyte differentiation, mammary gland epithelial cell proliferation) and core signaling axes (positive regulation of canonical Wnt signaling pathway; Hippo signaling), with DNA-templated transcription and apoptosis also represented. This suggests a cluster focused on epithelial growth and differentiation regulated by Wnt/Hippo signaling; supporting terms like caveolin-mediated endocytosis and potassium ion transport may reflect membrane trafficking and ion homeostasis in epithelial cells rather than core function.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006813","count":10},{"id":"GO:0060044","count":9},{"id":"GO:0006935","count":9},{"id":"GO:0030216","count":9},{"id":"GO:0090263","count":9}]},{"hash":"1435504491092786881","title":"Unknown","description":"The GO terms cover a mix of regulatory, signaling, developmental, and sensory processes (mRNA stability regulation; NOD2 signaling; venous endothelial differentiation; cardiac depolarization; pain sensing; mechanosensing; calcium transport; vitamin D response; prostate epithelial maturation), with no single unifying function. Therefore a concise, representative label cannot be confidently assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043488","count":5},{"id":"GO:0070431","count":4},{"id":"GO:0060843","count":4},{"id":"GO:1900827","count":4},{"id":"GO:0050966","count":4}]},{"hash":"831844128579502984","title":"Immune signaling and organ development","description":"The Top Terms show strong enrichment for immune-related processes (positive regulation of eosinophil degranulation; positive regulation of neutrophil killing of Gram-negative bacteria; dendritic cell chemotaxis; response to lipopolysaccharide) alongside developmental terms (lung connective tissue development; retina development; heart development; endothelial barrier establishment). This suggests the cluster comprises proteins involved in immune signaling that also participate in tissue development/remodeling, so a label focusing on immune signaling with developmental context seems most representative. While the connection is not perfectly cohesive (developmental terms extend beyond immunity), the prominent immune terms anchor the cluster's functional theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":13},{"id":"GO:0060427","count":13},{"id":"GO:0070963","count":13},{"id":"GO:0051482","count":13},{"id":"GO:0060041","count":13}]},{"hash":"241071624914484578","title":"Innate Immune Response and Inflammation Signaling","description":"This cluster is driven by immune-related GO terms: positive regulation of eosinophil degranulation, neutrophil-mediated killing of gram-negative bacteria, dendritic cell chemotaxis, and response to lipopolysaccharide, all pointing to innate immune activation and inflammatory signaling. The other terms (lung/heart/retina development and endothelial barrier regulation) appear as ancillary associations rather than a core theme, so the dominant signal remains innate immunity and inflammation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":15},{"id":"GO:0060427","count":15},{"id":"GO:0070963","count":15},{"id":"GO:0051482","count":15},{"id":"GO:0060041","count":15}]},{"hash":"1711110318397875053","title":"Embryogenesis and organ morphogenesis","description":"The top GO terms span multiple developmental and morphogenetic processes across several tissues and organs (hair follicle morphogenesis, cartilage morphogenesis, roof of the mouth, mesoderm and placental development, left-right patterning, EMT in endocardial cushion formation, pancreatic cell development, etc.), indicating a cohesive theme of embryonic development and tissue morphogenesis rather than a single tissue-specific function.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031069","count":15},{"id":"GO:0035270","count":15},{"id":"GO:0007498","count":15},{"id":"GO:0010957","count":15},{"id":"GO:0060972","count":15}]},{"hash":"1816941490296493740","title":"Cell-Cell Adhesion and Immune Regulation","description":"Most terms center on cell-cell adhesion (heterophilic/homophilic) and processes linked to immune modulation and synapse formation (negative regulation of NK cell cytotoxicity, macrophage activation, T cell degranulation, and actin cytoskeleton regulation by adhesion). An ossification term is present but peripheral. This suggests a cluster of proteins involved in adhesion-mediated immune interactions and synapse assembly.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":14},{"id":"GO:0007156","count":13},{"id":"GO:0051965","count":10},{"id":"GO:0043931","count":10},{"id":"GO:0002859","count":10}]},{"hash":"304510570977643828","title":"Neuronal adhesion and synapse assembly","description":"Top GO terms cluster around neuronal cell-cell adhesion and synapse-related processes (homophilic adhesion, paranodal junction assembly, AV node adhesion, regulation of synapse assembly, actin cytoskeleton organization by cell-cell adhesion). This points to a shared function in establishing and stabilizing neural connections. Some terms (sound detection, immune regulation) are less central, suggesting peripheral annotations, but the dominant signal supports neural adhesion and synapse organization.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":6},{"id":"GO:2000649","count":5},{"id":"GO:0030913","count":5},{"id":"GO:0002859","count":4},{"id":"GO:0043031","count":4}]},{"hash":"868336326710436060","title":"Developmental morphogenesis and transcription regulation","description":"These terms cluster around developmental morphogenesis across multiple tissues (cartilage, hair follicles, palate, left/right patterning) and include transcriptional regulation events (DNA-templated transcription, Pol II regulation). The combination suggests a group of proteins involved in regulating gene expression during embryonic development and tissue morphogenesis, rather than a single tissue-specific process.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":15},{"id":"GO:0060972","count":15},{"id":"GO:0006351","count":15},{"id":"GO:0000122","count":15},{"id":"GO:0060806","count":15}]},{"hash":"1398099115328081562","title":"Embryonic development and morphogenesis","description":"The dominant terms center on morphogenesis and organ development during embryogenesis, including cartilage formation, left-right patterning, placenta and pancreatic cell development, EMT in heart structures, and trophoblast differentiation. The presence of transcription-related terms suggests regulation of developmentally timed gene expression. Together they define a cohesive developmental/morphogenetic cluster.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":14},{"id":"GO:0060972","count":14},{"id":"GO:0060806","count":14},{"id":"GO:0035270","count":14},{"id":"GO:0003323","count":14}]},{"hash":"1216036616132814839","title":"Mitochondrial electron transport and protein import","description":"The top GO terms are dominated by mitochondrial functions: mitochondrial electron transport (NADH to ubiquinone and cytochrome c to oxygen), aerobic respiration, and respirasome assembly, as well as multiple terms for importing proteins into the mitochondrial matrix or inserting them into the inner membrane. This suggests the proteins cluster around mitochondrial energy production and protein targeting/import, with a few peripheral terms (like chloroplast import or response to food) that do not contradict the overall theme. Overall, the label captures the core shared function of the cluster.","confidence":"High","size":14,"edges":81,"triangles":267,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:1902600","count":3},{"id":"GO:0009060","count":3},{"id":"GO:0000002","count":2},{"id":"GO:0032094","count":2},{"id":"GO:0030150","count":2}]},{"hash":"775105361473251663","title":"ER Calcium Transport and Muscle Relaxation","description":"The cluster is dominated by GO terms about calcium ion transport to the endoplasmic reticulum, intracellular calcium homeostasis, and regulation of ER calcium concentration, along with terms tied to skeletal muscle relaxation and membrane repolarization. Together these point to coordinated Ca2+ handling in the ER/SR that drives muscle contraction\u2013relaxation cycles, with some ancillary ion transport and signaling terms. This supports labeling as ER calcium transport and muscle relaxation.","confidence":"High","size":14,"edges":37,"triangles":59,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1903515","count":10},{"id":"GO:0006874","count":10},{"id":"GO:0010751","count":10},{"id":"GO:0051208","count":10},{"id":"GO:0032470","count":10}]},{"hash":"1778988438430300123","title":"Lectin and Fc receptor innate signaling","description":"This cluster is dominated by innate immune signaling terms: cellular response to fungal origin, leukocyte tethering/rolling, stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, and complement activation via the lectin pathway. While there are a few developmental terms (metanephric tubule morphogenesis, cartilage condensation), the recurrent immune signaling themes strongly define the cluster\u2019s function.","confidence":"Medium","size":14,"edges":81,"triangles":262,"max_degree":13,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":14},{"id":"GO:0072237","count":12},{"id":"GO:0001867","count":12},{"id":"GO:0050901","count":12},{"id":"GO:0010572","count":12}]},{"hash":"2108403613777902068","title":"Spliceosome-mediated mRNA processing and export","description":"The top GO terms cluster around mRNA splicing (cis splicing, spliceosome activity, splice site recognition) and regulation of splicing, along with mRNA export and stabilization, including stress-responsive regulation of mRNA stability. This points to a set of proteins involved in mRNA maturation, splicing decisions, and post-transcriptional control. Hence this name reflects the common theme of spliceosome-driven mRNA processing and export.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":8},{"id":"GO:0006378","count":7},{"id":"GO:0010610","count":6},{"id":"GO:0048025","count":6},{"id":"GO:0048026","count":5}]},{"hash":"627543386811747604","title":"Skeletal muscle filament assembly and fiber development","description":"The top GO terms are dominated by skeletal muscle thin filament assembly and skeletal muscle fiber development, pointing to a muscle-specific cytoskeletal and morphogenesis program. Additional terms related to cytoskeletal dynamics and trafficking (endocytosis regulation, platelet aggregation) support a broader actin/cytoskeleton theme in muscle cells, despite some obsolete terms present. ","confidence":"High","size":14,"edges":82,"triangles":273,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0001300","count":3},{"id":"GO:0030240","count":3},{"id":"GO:1904623","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0030100","count":3}]},{"hash":"1598649827210108585","title":"Unknown","description":"The listed top GO terms span steroid hormone response, fertilization, retina homeostasis, immunity, and various metabolic processes, with no single dominant function linking the proteins, suggesting no coherent shared function for the cluster.","confidence":"","size":14,"edges":2,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:1903496","count":3},{"id":"GO:0007342","count":3},{"id":"GO:0009566","count":3},{"id":"GO:0001895","count":3},{"id":"GO:0042742","count":3}]},{"hash":"387315163851060763","title":"ER quality control and trafficking","description":"This cluster is dominated by GO terms tied to managing protein quality: ER-associated degradation (ERAD), handling misfolded proteins, aggresome assembly, and ER-to-Golgi transport, plus chaperone-mediated assembly and targeted protein import into organelles. While a few terms reference broader processes like transcription elongation and oxidative phosphorylation, the strongest signal is toward protein folding, quality control, and intracellular trafficking, suggesting this cluster centers on maintaining proteostasis across the secretory and organellar systems.","confidence":"Medium","size":14,"edges":73,"triangles":189,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:0071712","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0070842","count":4},{"id":"GO:0006888","count":4}]},{"hash":"1267424144883060985","title":"Chromatin-based transcriptional repression","description":"Most top GO terms converge on transcriptional repression and chromatin-level control: negative regulation of differentiation and signaling pathways, DNA-templated transcription, and multiple chromatin-related processes (rDNA heterochromatin formation, heterochromatin maintenance, nucleosome density, and histone deacetylation). This suggests the cluster is coordinated around chromatin remodeling and histone modification that suppress gene expression. ","confidence":"High","size":14,"edges":79,"triangles":249,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045668","count":10},{"id":"GO:0006351","count":10},{"id":"GO:0060766","count":10},{"id":"GO:0010832","count":8},{"id":"GO:0000183","count":7}]},{"hash":"1597973958432841923","title":"Ribosome Biogenesis and Cell Cycle Regulation","description":"The cluster is strongly enriched for ribosome biogenesis and ribosomal subunit export from the nucleus, along with cell division and cell cycle terms, pointing to proteins involved in ribosome assembly and cell cycle progression. A few terms (ossification, vitamin D response, B cell homeostasis) are less connected and may reflect broader or overlapping annotations.","confidence":"High","size":14,"edges":16,"triangles":3,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000055","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0007049","count":7},{"id":"GO:0043931","count":6},{"id":"GO:0033280","count":6}]},{"hash":"1266317355126727658","title":"Mitochondrial Transport and Bioenergetics Regulation","description":"The cluster is dominated by mitochondrial-related processes: ADP/ATP transmembrane transport, phosphate ion transport, magnesium export from mitochondria, and iron import into mitochondria, along with mitochondrial membrane fission and regulation of membrane potential. These together point to a shared role in mitochondrial transport and energy management, with related metabolic signaling (insulin response, amino acid starvation) providing physiological context. ","confidence":"High","size":14,"edges":16,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":7},{"id":"GO:0048250","count":5},{"id":"GO:0035435","count":5},{"id":"GO:0015866","count":5},{"id":"GO:0090149","count":5}]},{"hash":"1947648627363087471","title":"Spliceosome and RNA processing","description":"This cluster is dominated by RNA maturation functions\u2014mRNA splicing via the spliceosome, snRNP/complex assembly, transcription termination, tRNA processing, and nuclear import\u2014with supportive links to mRNA decay and P-body association, pointing to a coherent spliceosome/RNA-processing module.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":14},{"id":"GO:0033962","count":12},{"id":"GO:0009414","count":12},{"id":"GO:0000387","count":12},{"id":"GO:0006369","count":12}]},{"hash":"1759121190632359084","title":"Spliceosome-driven mRNA processing and export","description":"Top GO terms cluster around splicing and mRNA processing: positive/negative regulation of mRNA splicing via spliceosome, mRNA splice site recognition, and mRNA cis splicing via spliceosome, as well as mRNA stability and export. The presence of translation preinitiation complex formation suggests a link to translation readiness, tying post-transcriptional processing to translation initiation. Stress-related mRNA stability and regulatory ncRNA-mediated gene silencing indicate broader control of gene expression at the RNA level. Taken together, these proteins likely participate in coordinated regulation of mRNA splicing, maturation, and nuclear export, with potential implications for stress responses and translation control.","confidence":"High","size":14,"edges":18,"triangles":8,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0001731","count":6},{"id":"GO:0010610","count":6},{"id":"GO:1901407","count":6}]},{"hash":"213223988729811553","title":"Immune cell granule secretion and vesicle trafficking","description":"The top terms cluster around degranulation in NK, eosinophils, neutrophils, and mast cells, combined with ER-Golgi and intra-Golgi vesicle transport and vacuolar membrane targeting/fusion. This points to a shared function in secretory granule dynamics and regulated release in immune responses.","confidence":"High","size":14,"edges":38,"triangles":49,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0035987","count":7},{"id":"GO:0006888","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0043320","count":2},{"id":"GO:1900483","count":2}]},{"hash":"1721382016440258032","title":"Neuronal Signaling and Synaptic Development","description":"This cluster is dominated by neural signaling and development themes: Wnt signaling regulation, ERK/JNK cascades, ephrin receptor signaling, excitatory postsynaptic potential, actin cytoskeleton remodeling, and hippocampus development. These terms together point to pathways involved in synaptic signaling and neural development. Some immune signaling terms appear (T cell receptor signaling, beta selection), which may reflect shared signaling components rather than a core immune function of the cluster, but the predominant pattern remains neuronal signaling.","confidence":"Medium","size":14,"edges":4,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":13},{"id":"GO:0043552","count":11},{"id":"GO:0060079","count":11},{"id":"GO:0050852","count":11},{"id":"GO:0070374","count":11}]},{"hash":"1978629318042742136","title":"Chromatin Modification and Transcription Regulation","description":"The top GO terms emphasize histone methylation (chromatin modification), DNA-templated transcription and its regulation, and mRNA processing, suggesting a cohesive theme of gene expression control at both epigenetic and transcriptional levels. Some unrelated terms appear, but the dominant signal centers on transcriptional regulation and chromatin state.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048668","count":3},{"id":"GO:0008277","count":3},{"id":"GO:0051568","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0034729","count":3}]},{"hash":"2020368531769531676","title":"Lymphocyte signaling and germinal center processes","description":"The top GO terms are strongly centered on adaptive immunity and lymphocyte activity (B cell receptor signaling, germinal center formation, memory T cell differentiation, type 2 immune response, mast cell cytokine regulation). This suggests the proteins cluster around immune signaling and lymphocyte development, despite a couple of outlier terms. ","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900477","count":3},{"id":"GO:0045497","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0002467","count":3},{"id":"GO:0042092","count":3}]},{"hash":"1484231596023856601","title":"Neural development and ECM adhesion","description":"These proteins cluster around neural development processes such as synapse assembly, myelination, corpus callosum development, and peripheral nervous system axon regeneration, while also prominently featuring extracellular matrix organization and cell-matrix adhesion. This suggests a coherent theme of nervous system development with ECM-mediated signaling and adhesion.","confidence":"High","size":14,"edges":11,"triangles":1,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030199","count":7},{"id":"GO:0007169","count":6},{"id":"GO:0051965","count":6},{"id":"GO:0042552","count":6},{"id":"GO:0022038","count":6}]},{"hash":"19182868662426850","title":"Neural development and axon guidance","description":"The top GO terms cluster around nervous system development, including myelination, lens fiber differentiation, corticospinal axon guidance, and regulation of branching morphogenesis of a nerve, which together point to roles in neuronal connectivity and maturation. Some terms like mitochondrial electron transport are more general, but the dominant signal is neural development and axon guidance.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0060427","count":1}]},{"hash":"363305754522961005","title":"Neurovascular development and differentiation","description":"This cluster combines neural development terms (spinal cord neuron and oligodendrocyte fates, amacrine and GABAergic interneuron differentiation, floor plate) with vascular development terms (lung vasculature, bronchiole development, vascular wound healing) and some related transcriptional regulation (RNA polymerase II). The shared theme appears to be coordinated developmental patterning across neural and vascular lineages, justifying the label \u201cneurovascular development and differentiation.\u201d","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0035470","count":7},{"id":"GO:0031018","count":6},{"id":"GO:0021530","count":5},{"id":"GO:0021520","count":5}]},{"hash":"1458005586580174977","title":"Monocyte Activation and Inflammatory Cytokine Signaling","description":"This cluster is driven by terms tied to immune activation and inflammatory signaling in monocytes, including cellular responses to TNF and IL-1, and monocyte activation itself. Additional terms like Notch signaling, TGF-beta response, and angiogenesis point to signaling cross-talk that accompanies inflammation and vascular remodeling. Proteolysis and nuclear import regulation further support dynamic cellular responses during inflammation. Overall, the common theme is immune cell activation and pro-inflammatory signaling pathways.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0042117","count":5},{"id":"GO:0071356","count":5},{"id":"GO:0071347","count":5},{"id":"GO:0010259","count":4},{"id":"GO:0045766","count":4}]},{"hash":"1816114461294488702","title":"Calcium signaling in neurons and muscles","description":"These proteins cluster around calcium-dependent signaling, with several GO terms emphasizing release of sequestered calcium into the cytosol, calcium modulation in signaling pathways (e.g., Wnt calcium pathway, adenylate cyclase activation), and processes tied to neural development and function (axonogenesis, visual perception, synaptic plasticity). While there are also terms related to kidney development and cardiac muscle calcium regulation, the dominant theme is calcium-mediated signal transduction in neural contexts, justifying a label focused on calcium signaling in neurons and muscles. ","confidence":"Medium","size":14,"edges":19,"triangles":9,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":7},{"id":"GO:0007223","count":6},{"id":"GO:0007190","count":6},{"id":"GO:0048168","count":6},{"id":"GO:0072205","count":6}]},{"hash":"2021160362104549763","title":"Secretory Vesicle Trafficking","description":"The top GO terms center on ER-to-Golgi and Golgi-to-plasma membrane transport, including retrograde ER\u2013Golgi transport and regulation of intracellular protein transport, which together define the secretory pathway. Additional terms point to signaling and cytoskeletal regulation that often accompany trafficking and protein turnover, supporting a cohesive trafficking-focused cluster.","confidence":"High","size":14,"edges":19,"triangles":0,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":6},{"id":"GO:0090316","count":6},{"id":"GO:0043001","count":6},{"id":"GO:0070374","count":5},{"id":"GO:0043149","count":5}]},{"hash":"1888483039703589453","title":"Developmental Signaling and Membrane Dynamics","description":"Most terms cluster around cell signaling pathways (ERK cascade, GTPase regulation, PI signaling) and membrane-related processes (plasma membrane repair, vesicle exocytosis, PI3K activity). The inclusion of ossification and multicellular development links these signaling events to growth and organismal development, including fungal morphogenesis. This pattern supports a label focused on signaling-driven membrane dynamics in development.","confidence":"Medium","size":14,"edges":10,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0001778","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0007275","count":2}]},{"hash":"169005877188624303","title":"Multi-organ development and morphogenesis","description":"The top GO terms cluster around organogenesis across multiple tissues: eye/retina development, embryonic eye morphogenesis, lung morphogenesis, pituitary gland development, osteoblast development, and even broader terms like transcription by RNA polymerase II. This suggests proteins acting in module(s) of developmental programs that span several organs rather than a single tissue-specific function. Confidence: Medium","confidence":"","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0035470","count":5},{"id":"GO:0021983","count":5},{"id":"GO:0060041","count":5},{"id":"GO:0045348","count":4}]},{"hash":"71350422876014149","title":"Ubiquitination and Proteasomal Degradation","description":"The top terms are all tied to ubiquitin-mediated protein turnover, including ubiquitin-dependent catabolic processes, various ubiquitin linkages (K48, K63, K6), autoubiquitination, and SCF-proteasome\u2013dependent degradation. The presence of ERAD-related and histone turnover terms further supports a core theme around ubiquitin tagging and proteasomal degradation, with additional signaling roles in JNK and TNF pathways. This cohesive pattern strongly indicates a cluster focused on ubiquitination-driven protein degradation.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0070936","count":8},{"id":"GO:0051865","count":7},{"id":"GO:0030433","count":7},{"id":"GO:0046328","count":6}]},{"hash":"973594552979470290","title":"Developmental ECM Remodeling and Signaling","description":"The prominent GO terms cluster around extracellular matrix organization and developmental processes, including lung development, trophoblast differentiation, axonal fasciculation, and regulation of myotube differentiation. They also involve signaling pathways such as Rho-mediated transduction and TGF-beta receptor signaling, which tie into ECM remodeling and cell differentiation. While other terms like macrophage activation and transcriptional regulation appear, the overall pattern supports a theme of tissue development and matrix dynamics rather than a single narrow function.","confidence":"Medium","size":14,"edges":9,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1901998","count":3},{"id":"GO:0010832","count":2},{"id":"GO:0007266","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0030324","count":2}]},{"hash":"1523886661519456020","title":"Nuclear transcription regulation and nucleotide salvage","description":"The cluster shows strong signals for DNA-templated transcription and RNA Pol II transcription regulation, suggesting a core role in nuclear transcription control. The presence of nucleotide salvage terms (CTP and UMP salvage) and phosphorylation hints at linked regulatory processes affecting transcription machinery, despite several terms being marked obsolete. Overall, the dominant theme appears to be transcriptional regulation, with a secondary tie to nucleotide metabolism.","confidence":"Medium","size":14,"edges":17,"triangles":0,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070895","count":6},{"id":"GO:0046022","count":6},{"id":"GO:0007576","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0010729","count":6}]},{"hash":"1985783258257113497","title":"Neural, vascular, and immune developmental signaling","description":"These proteins tag multiple development-related processes across tissues: angiogenesis and endothelial migration (vascular), forebrain development and Bergmann glial differentiation (neural), thymus development and T cell receptor signaling (immune). Additional terms for nitric oxide response and stress fiber regulation point to broader cellular signaling and morphogenesis. There isn\u2019t a single unified pathway, but a cohesive theme of developmental signaling across organ systems, suggesting a Moderate level of coherence.","confidence":"Medium","size":14,"edges":29,"triangles":15,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:2001275","count":13},{"id":"GO:0050852","count":13},{"id":"GO:0048538","count":13},{"id":"GO:0043536","count":13},{"id":"GO:0001525","count":13}]},{"hash":"465801290755038221","title":"Innate Immunity and Cytoskeleton Signaling","description":"This cluster is driven by innate immune terms (innate immune response, defense against virus) and by signaling/cytoskeleton regulation (actin cytoskeleton, JNK cascade, microtubule localization), with some development terms likely reflecting immune cell biology. The lack of edges suggests these proteins cover related signaling and cytoskeletal roles across immune and developmental contexts rather than a single pathway.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0032956","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0001782","count":3}]},{"hash":"1785940699176907510","title":"Cell signaling and cell cycle regulation","description":"The top GO terms point to signaling pathways (Wnt, B cell receptor, PARylation) alongside cell-cycle\u2013related processes (spindle assembly, telomere maintenance, mitotic cohesion) and apoptosis regulation, suggesting a cluster of proteins that integrate extracellular signals with decisions about proliferation, genome maintenance, and stress responses rather than a single pathway.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043066","count":5},{"id":"GO:0071260","count":5},{"id":"GO:0050853","count":4},{"id":"GO:1904357","count":4},{"id":"GO:0007205","count":4}]},{"hash":"1094035002953568852","title":"Organ Development and Vision-Related Processes","description":"This cluster's top GO terms converge on organ and tissue development (heart, lung connective tissue, retina, endothelial barrier) and sensory/visual processes (visual learning, retina development). While a xenobiotic response term is present, the strongest signal points to multi-organ developmental pathways with a emphasis on vision-associated tissues and vascular biology.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042493","count":13},{"id":"GO:0008542","count":13},{"id":"GO:0040015","count":13},{"id":"GO:0043311","count":12},{"id":"GO:0060427","count":12}]},{"hash":"1887742445510482700","title":"Organ Development and Innate Immunity","description":"This cluster mixes organ development terms (heart, retina, lung connective tissue, endothelial barrier) with innate immune processes (eosinophil degranulation, neutrophil killing, dendritic cell chemotaxis, response to lipopolysaccharide), suggesting proteins involved in both developmental contexts and innate immune signaling rather than a single narrow function.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":11},{"id":"GO:0060427","count":11},{"id":"GO:0070963","count":11},{"id":"GO:0051482","count":11},{"id":"GO:0060041","count":11}]},{"hash":"2178411806078941045","title":"Unknown","description":"The top GO terms span cardiovascular regulation, energy metabolism, GPCR signaling, Rho signaling, vision, immune cell degranulation, lung development, and neutrophil killing, indicating a highly diverse, non-specific set of functions rather than a single cohesive theme. Therefore there isn\u2019t a clear, representative function to label this cluster.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":8},{"id":"GO:0022900","count":8},{"id":"GO:0010579","count":8},{"id":"GO:0035025","count":8},{"id":"GO:0008542","count":7}]},{"hash":"1225231014414353487","title":"Neuronal development and synaptic plasticity with microtubule transport","description":"Top terms point to neuronal development and synaptic plasticity (neuron projection development, long-term potentiation) and cytoskeletal transport/anchoring (minus-end directed transport, MTOC anchoring); together with signaling regulation terms (JNK cascade), this cluster likely comprises neuronal signaling with cytoskeletal transport components.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900275","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0010976","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0060291","count":2}]},{"hash":"1993039062498926089","title":"Cardiac GPCR Signaling and Heart Contractility","description":"This cluster centers on GO terms for heart development and cardiac muscle contraction, and includes GPCR signaling pathways (tachykinin and acetylcholine receptors) with receptor desensitization/internalization and associated phosphorylation, indicating a coherent module of cardiac signaling and regulation of heart muscle function.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0045988","count":3},{"id":"GO:0002029","count":3},{"id":"GO:0007217","count":3},{"id":"GO:0007213","count":3}]},{"hash":"389205548097470730","title":"Unknown","description":"The top GO terms are highly diverse, covering taste detection, phototaxis, lateral line development, GABA signaling, electron transport, and broad regulatory processes, with no clear shared function tying the proteins together. The absence of edges/triangles and presence of obsolete terms suggest a noisy, non-cohesive set rather than a single biological theme, so I label this cluster Unknown with no confidence.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001582","count":14},{"id":"GO:0042331","count":14},{"id":"GO:0048899","count":14},{"id":"GO:0007214","count":14},{"id":"GO:0022900","count":14}]},{"hash":"1221137567414358617","title":"Quinone Biosynthesis and Metabolic Catabolism","description":"The cluster is marked by quinone biosynthesis (menaquinone, phylloquinone) and multiple catabolic and energy-related processes (mandelate and amino acid catabolism, gluconeogenesis) plus cell wall remodeling, which together point to a metabolism- and energy-generation-focused module, likely bacterial. Some terms (e.g., skeletal muscle regeneration, obsolete pathogenesis) appear as noise but do not override the central metabolic theme.","confidence":"Medium","size":14,"edges":35,"triangles":56,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0009405","count":7},{"id":"GO:1903298","count":5},{"id":"GO:0019596","count":5},{"id":"GO:0009234","count":5},{"id":"GO:0043403","count":5}]},{"hash":"1285300442875268663","title":"Unknown","description":"The terms span sensory, neural development, immune regulation, heart development, apoptosis, lipid transport, and vesicle processes with no clear shared function, making a cohesive label inappropriate. Therefore, the cluster is best described as Unknown with no confident single theme.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0001782","count":3},{"id":"GO:0061000","count":3}]},{"hash":"285467515404226288","title":"Neural development and signaling","description":"The cluster's frequent GO terms center on neural development and signaling activities: Wnt signaling, sensory perception of sound, GPCR-mediated signaling, sympathetic nervous system development, and axon regeneration. Additional terms reference cellular processes like protein tetramerization and spindle assembly, which can be relevant during neural development. Overall, the theme points to molecules involved in neural differentiation, communication, and repair, making Neural development and signaling an intuitive label.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0051262","count":3},{"id":"GO:0051225","count":3}]},{"hash":"727025048340787180","title":"Inflammation, coagulation, and vascular signaling","description":"The proteins show strong enrichment for inflammatory and immune-related processes (response to lipopolysaccharide, neutrophil and eosinophil activities) and coagulation, along with calcium and GPCR signaling and endothelial barrier regulation. While some development terms appear, the core pattern points to inflammation-driven vascular responses rather than a single metabolic pathway.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032496","count":11},{"id":"GO:0007596","count":11},{"id":"GO:0035625","count":11},{"id":"GO:0051281","count":11},{"id":"GO:0043311","count":10}]},{"hash":"1698500391333597312","title":"Immune Activation and Tissue Development","description":"The cluster\u2019s enriched terms span immune effector functions (eosinophil degranulation, neutrophil-mediated killing of Gram-negative bacteria, response to LPS, dendritic cell chemotaxis) and developmental/tissue contexts (lung connective tissue development, heart development, retina development, endothelial barrier regulation). This suggests proteins involved in inflammatory signaling linked to tissue remodeling and organ development, rather than a single canonical pathway.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":14},{"id":"GO:0060427","count":14},{"id":"GO:0070963","count":14},{"id":"GO:0051482","count":14},{"id":"GO:0060041","count":14}]},{"hash":"368692951914131283","title":"Immune Response and Tissue Development","description":"The cluster is enriched for immune-related processes (positive regulation of eosinophil degranulation, positive regulation of neutrophil killing of gram-negative bacteria, dendritic cell chemotaxis, response to lipopolysaccharide) along with organ/tissue development terms (lung connective tissue development, retina development, heart development, endothelial barrier regulation), suggesting proteins involved in inflammatory signaling that also influence tissue morphogenesis or barrier formation.","confidence":"Medium","size":14,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":13},{"id":"GO:0060427","count":13},{"id":"GO:0070963","count":13},{"id":"GO:0051482","count":13},{"id":"GO:0060041","count":13}]},{"hash":"292733499457729773","title":"Unknown","description":"The terms span immune activation (eosinophil/neutrophil functions, DC chemotaxis, LPS response) and broad development signals (lung tissue, heart, retina) plus signaling pathways and endothelial regulation, with no single coherent function tying all proteins together. This lack of a unifying theme justifies an Unknown label.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":14},{"id":"GO:0060427","count":14},{"id":"GO:0070963","count":14},{"id":"GO:0051482","count":14},{"id":"GO:0060041","count":14}]},{"hash":"350964108724674563","title":"Embryonic Development and Morphogenesis","description":"These GO terms point to broad embryonic development, tissue morphogenesis, and patterning across organs (heart cushion EMT, cartilage and hair follicle morphogenesis, placenta/endocrine development, left-right patterning, pancreatic cell development), with some transcriptional regulation notes, indicating a general developmental program rather than a single function.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":13},{"id":"GO:0060707","count":13},{"id":"GO:0060536","count":13},{"id":"GO:0060806","count":13},{"id":"GO:0060972","count":13}]},{"hash":"1803739823165325913","title":"Mitochondrial RNA Processing and Respiration","description":"The top GO terms cluster around mitochondrial RNA processing, mitochondrial large ribosomal subunit assembly, and cellular respiration, indicating a cohesive theme of mitochondrial gene expression and energy metabolism. The chloroplast rRNA processing term and a few scattered terms suggest possible plastid annotations or dual-targeted proteins, but the dominant signal is mitochondrial RNA handling and respiration. The lack of edges implies this is an annotation-driven grouping rather than a tightly connected protein complex.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070584","count":2},{"id":"GO:0071897","count":2},{"id":"GO:0019216","count":1},{"id":"GO:0050905","count":1},{"id":"GO:0031413","count":1}]},{"hash":"413310501942795434","title":"Immune regulation and trafficking","description":"The top terms point to innate and adaptive immune regulation: neutrophil extravasation and homeostasis, NK cell and gamma-delta T cell regulation, macrophage activation control, and dampening of TLR/MyD88 signaling with IL-10\u2013related regulation. These collectively suggest a module focused on recruitment and modulation of immune responses; the spermatid development term is likely incidental. ","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072672","count":7},{"id":"GO:0002859","count":7},{"id":"GO:0006508","count":7},{"id":"GO:0043031","count":7},{"id":"GO:2001181","count":7}]},{"hash":"1632911802987220538","title":"Sensory organ development and epithelial junctions","description":"The cluster is enriched for terms linking sensory tissues (sensory perception of sound; camera-type eye photoreceptor cell differentiation) with epithelial barrier/junction formation (bicellular tight junction assembly; smooth septate junction assembly). Additional signals like Notch/VEGF regulation and receptor internalization support developmental signaling contexts in sensory epithelia. Together, these terms point to a coherent theme of sensory organ development with junctional organization.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0030886","count":2},{"id":"GO:0061462","count":2}]},{"hash":"2088963796717511005","title":"ESCRT-Driven Vesicle Trafficking and Cytokinesis","description":"The Top Terms are dominated by ESCRT-related processes: multivesicular body (MVB) trafficking and sorting, MVB-lysosome fusion, exosomal secretion, abscission, and viral budding via the ESCRT complex. Additional terms like exit from mitosis and nucleus organization align with cell-cycle\u2013related membrane remodeling. Taken together, these proteins appear to function as a cluster centered on ESCRT-dependent vesicle trafficking, exosome pathways, and cytokinesis. High","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048146","count":2},{"id":"GO:0014834","count":2},{"id":"GO:0061763","count":1},{"id":"GO:0030713","count":1},{"id":"GO:0010458","count":1}]},{"hash":"1334525943744787785","title":"Embryonic morphogenesis and patterning","description":"The top GO terms cluster around tissue morphogenesis (cartilage, hair follicle, roof of mouth) and left/right pattern formation, with concurrent transcriptional regulation, indicating a developmental/morphogenesis-focused cluster.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":14},{"id":"GO:0060972","count":14},{"id":"GO:0006351","count":14},{"id":"GO:0000122","count":14},{"id":"GO:0060806","count":14}]},{"hash":"2219431430809532539","title":"Vacuolar transport and mitochondrial energy metabolism","description":"The cluster's GO terms center on vacuolar functions (protein targeting to vacuole, vacuole organization, vacuolar acidification) and energy-related processes (ubiquinone biosynthesis, proton transmembrane transport, proton motive force-driven ATP synthesis), with occasional ion handling themes (sodium and copper ions). This suggests a cohesive role in maintaining organelle transport and energy homeostasis, particularly involving vacuolar activity and mitochondrial energy metabolism.","confidence":"High","size":13,"edges":32,"triangles":19,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006814","count":2},{"id":"GO:0006744","count":2},{"id":"GO:0035167","count":1},{"id":"GO:0006623","count":1},{"id":"GO:0007033","count":1}]},{"hash":"171727214170991299","title":"Metal stress and unfolded protein response","description":"The top GO terms indicate cellular responses to cadmium and lead ions (metal stress) and to the unfolded protein response, pointing to stress sensing and protein quality control under metal exposure. Additional terms on protein complex assembly and transcription-related processes suggest downstream regulatory adaptations to this stress. Overall, the cluster centers on metal-induced stress coupled with protein folding/quality control mechanisms.","confidence":"Medium","size":13,"edges":9,"triangles":7,"max_degree":4,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0071276","count":6},{"id":"GO:0051291","count":6},{"id":"GO:0090526","count":6},{"id":"GO:0006986","count":6},{"id":"GO:0071357","count":6}]},{"hash":"1613714786208267928","title":"Ribosome assembly and transcription machinery","description":"The dominant GO terms are translation, ribosomal large subunit assembly, and DNA-templated transcription, pointing to core protein synthesis and gene expression machinery. While a few metabolic processes appear, the strongest and most frequent signals center on ribosome biogenesis and transcription, justifying this label.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0017148","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000027","count":1}]},{"hash":"1300517116280932912","title":"Transmembrane transport of nutrients and ions","description":"The top GO terms are dominated by various transmembrane transport processes (pantothenate, biotin, myo-inositol, glucose, sodium, and proton transport), indicating a cluster of membrane transporter proteins handling small molecules and ions. A couple of outlier terms (developmental processes) are present but far less represented. ","confidence":"High","size":13,"edges":19,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0015887","count":6},{"id":"GO:0015878","count":6},{"id":"GO:0015798","count":6},{"id":"GO:0071436","count":6},{"id":"GO:0008292","count":6}]},{"hash":"1316674860789083899","title":"Cofactor and vitamin biosynthesis","description":"This cluster features GO terms centered on biosynthesis of vitamins and cofactors (biotin, cobalamin, thiamine) and related metabolic routes (porphyrinogen/heme precursor, 2-oxoglutarate), plus several amino-acid\u2013related pathways, indicating a cohesive theme around metabolic biosynthesis. A few terms related to transcription or tRNA modification are less aligned but do not outweigh the core biosynthetic pattern.","confidence":"Medium","size":13,"edges":32,"triangles":46,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0042853","count":5},{"id":"GO:0006782","count":4},{"id":"GO:0009102","count":4},{"id":"GO:0009236","count":4}]},{"hash":"645256783782474679","title":"Neural development and cell cycle regulation","description":"This cluster is enriched for neural development terms (neuron projection development, spinal cord development, embryonic organ development) together with cell division and transcription processes (mitotic spindle assembly, cell division, DNA-templated transcription), and regulatory signals such as apoptotic process and TGF-beta response, as well as protein interactions. This suggests a theme of neural development intertwined with proliferation and transcriptional control.","confidence":"Medium","size":13,"edges":37,"triangles":51,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090307","count":5},{"id":"GO:0031175","count":4},{"id":"GO:0048568","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0051260","count":4}]},{"hash":"1500990315936543155","title":"Nucleotide catabolic processes","description":"The top GO terms are dominated by catabolic processes for several nucleotides (CDP, GDP, UDP, ADP), indicating a core theme of nucleotide degradation. While there are offshoot terms related to glycosylation and pollen development, the strongest and most consistent signal across the cluster is nucleotide catabolism, justifying this label.","confidence":"Medium","size":13,"edges":56,"triangles":132,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0046706","count":5},{"id":"GO:0046712","count":5},{"id":"GO:0006256","count":5},{"id":"GO:0046032","count":5},{"id":"GO:0009901","count":5}]},{"hash":"260286292560837203","title":"Neural development and synapse assembly","description":"The set of GO terms centers on nervous system development, neurogenesis, cerebral cortex development, and synapse assembly, with sensory perception terms reinforcing neural function. A few terms relate to immune/epithelial processes, which may reflect broader protein roles or annotation noise, but the dominant theme is CNS development and synaptogenesis.","confidence":"High","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0071285","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0022008","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0030277","count":3}]},{"hash":"825288553510000101","title":"ERAD and UPR-driven protein quality control","description":"The cluster shows prominent involvement in ER-associated degradation (ERAD) and unfolded protein response (UPR), including ubiquitin-dependent ERAD, positive regulation of ERAD, response to unfolded protein, and misfolded protein transport. These terms together point to a proteostasis theme centered on ER quality control and management of misfolded proteins, with a few unrelated terms (developmental patterning and DNA replication) likely incidental. Confidence: Medium","confidence":"","size":13,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:1904294","count":2},{"id":"GO:0048190","count":2},{"id":"GO:1901215","count":2},{"id":"GO:1900035","count":2}]},{"hash":"2005226677649209624","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":15,"triangles":3,"max_degree":6,"top_function":"cytoskeleton organization","top_go_terms":[{"id":"GO:0044205","count":4},{"id":"GO:0007411","count":4},{"id":"GO:0009442","count":4},{"id":"GO:0030516","count":4},{"id":"GO:0048678","count":4}]},{"hash":"1521547290454698950","title":"Developmental Signaling Regulators","description":"These proteins appear to function as regulators of multiple signaling and developmental processes. The top GO terms point to positive regulation of canonical Wnt signaling, regulation of JNK and TGF-beta\u2013mediated responses, and processes related to cell fate specification and cell migration, complemented by broader regulatory activities such as GTPase regulation and translational control. This pattern suggests a theme of coordinating signaling pathways during development rather than performing a single enzymatic task.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0090263","count":5},{"id":"GO:0006915","count":5},{"id":"GO:0046328","count":5},{"id":"GO:0043547","count":5},{"id":"GO:1903679","count":5}]},{"hash":"1453814727796495872","title":"Metabolic Pathways and Stress Response","description":"The top terms cluster around retinol/retinal and lipid/sterol metabolism, plus glutathione biosynthesis, cadmium ion response, and apoptosis regulation, suggesting a broad metabolism theme intertwined with cellular stress handling rather than a single specific pathway.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":13},{"id":"GO:0042574","count":13},{"id":"GO:0006750","count":7},{"id":"GO:0071276","count":7},{"id":"GO:0061370","count":7}]},{"hash":"1439279667381839164","title":"Neuronal stress signaling and neuroprotection","description":"These proteins appear to function in neuronal signaling and stress responses, with enrichment for ERK/MAPK cascade regulation and AKT activation, alongside cellular responses to xenobiotics, cadmium, nitric oxide, and cytokines. The inclusion of substantia nigra development suggests a dopaminergic neuron context, supporting a theme of neuronal stress signaling and neuroprotection rather than a single isolated pathway. ","confidence":"High","size":13,"edges":19,"triangles":6,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0043524","count":4},{"id":"GO:0000060","count":4},{"id":"GO:0035690","count":4},{"id":"GO:0021762","count":3}]},{"hash":"421655467558909949","title":"Detoxification and Oxidative Stress Response","description":"This cluster shows multiple GO terms tied to detoxification and redox biology, including cellular oxidant detoxification, detoxification of mercury ion, and glutathione metabolic process, as well as glycolytic energy metabolism. While there are some development- and chromatin-related terms that may reflect broader regulatory roles, the strongest signal is detox/metabolic response to oxidative stress, suggesting proteins that participate in detox pathways and related metabolism.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":4},{"id":"GO:0021987","count":4},{"id":"GO:0051573","count":4},{"id":"GO:0016575","count":4},{"id":"GO:0045793","count":4}]},{"hash":"2284373429982782317","title":"Centromeric chromatin assembly and heterochromatin formation","description":"The top GO terms are dominated by centromere-related chromatin activities (CENP-A containing chromatin assembly, chromatin localization to chromatin) and heterochromatin formation (including rDNA and silent mating-type loci), with supporting DNA repair, indicating a coherent function in chromatin organization and centromere maintenance. A few terms on aggresome/autophagy are less central. ","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0070842","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0071169","count":2},{"id":"GO:0061641","count":2},{"id":"GO:0006281","count":2}]},{"hash":"1780278075871749800","title":"Neuronal sensory signaling and drug response","description":"These proteins are enriched for GO terms tied to sensory perception (pain, vision), brain-related behavioral responses to psychoactive substances (morphine, cocaine), and signaling cascades (ERK, GTPase) that link sensory inputs to neuronal responses. The combination suggests a cluster of neural signaling components involved in sensory processing and pharmacological response.","confidence":"High","size":13,"edges":59,"triangles":119,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0008542","count":8},{"id":"GO:0070374","count":8},{"id":"GO:0071380","count":8},{"id":"GO:0048148","count":8}]},{"hash":"565918657210583834","title":"Translational Regulation and Proteostasis","description":"The cluster is enriched for translation-related GO terms (translation, ribosome biogenesis, regulation of translational initiation) and for proteasomal ubiquitin-dependent protein catabolic process, suggesting a cohesive theme of protein synthesis control and protein turnover. Additional terms like cellular response to nitric oxide and caveolin-mediated endocytosis may reflect broader cellular stress handling but do not override the core ribosome/protein degradation signal.","confidence":"Medium","size":13,"edges":62,"triangles":158,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0071732","count":3},{"id":"GO:0019509","count":3},{"id":"GO:0019284","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0007275","count":3}]},{"hash":"1094649635936733347","title":"ER protein quality control and deubiquitination","description":"The top GO terms cluster around protein deubiquitination, ERAD (ubiquitin-dependent ER-associated degradation), regulation of endopeptidase activity, and deglycosylation, indicating a module centered on ER proteostasis and ubiquitin-mediated turnover. Negative/regulatory terms further suggest tuning of ubiquitin/protease activity within this pathway, despite some obsolete annotations. Overall, the cluster appears to represent ER-associated protein quality control and ubiquitin-dependent degradation.","confidence":"High","size":13,"edges":72,"triangles":229,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0010950","count":4},{"id":"GO:0006517","count":3},{"id":"GO:2000157","count":3}]},{"hash":"558043684610807438","title":"Unknown","description":"The terms cover xenobiotic response, inflammatory signaling, proteolysis (including membrane proteins), various signaling pathways, and distinct development processes (retina and mesonephros). This mix does not reveal a single cohesive function or pathway governing the cluster, so a unified label is not evident.","confidence":"","size":13,"edges":12,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":2},{"id":"GO:0042985","count":1},{"id":"GO:0070305","count":1},{"id":"GO:0042756","count":1},{"id":"GO:0009755","count":1}]},{"hash":"1376785199862350451","title":"Innate Immune and Inflammatory Signaling cluster","description":"Based on the top GO terms, the cluster is enriched for innate immune response, cellular response to lipopolysaccharide, positive regulation of inflammatory response, and related signaling activities, suggesting a core theme around immune sensing and inflammatory signaling. Some terms related to development or perception appear as noise, but the strongest cohesive signal centers on immune/inflammatory pathways. Confidence: Medium","confidence":"","size":13,"edges":16,"triangles":4,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":5},{"id":"GO:0071222","count":5},{"id":"GO:0008286","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0007601","count":4}]},{"hash":"605894433630158133","title":"Membrane Transporters for Xenobiotics and Sugars","description":"This cluster is enriched for transmembrane transport GO terms across a range of substrates: xenobiotics, vitamins, potassium ions, phosphates, nitrates, and sugars (D-xylose, arabinose, fructose). The common theme is membrane transporter activity with broad substrate specificity, indicating a group of transporter proteins rather than a single substrate class.","confidence":"High","size":13,"edges":53,"triangles":84,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":13},{"id":"GO:0035461","count":13},{"id":"GO:0071805","count":11},{"id":"GO:0042908","count":11},{"id":"GO:0042891","count":9}]},{"hash":"1706162189670488133","title":"Neural and muscle development and regulation","description":"The proteins are enriched for neural development terms (neural tube closure, forebrain development, enteric nervous system development) and for regulation of muscle differentiation (negative regulation of myotube differentiation, negative regulation of skeletal and cardiac muscle cell differentiation, with some positive regulation of cardiac muscle differentiation), suggesting a coordinated developmental program affecting neural and muscular lineages. A few terms point to broader regulatory pathways, but the dominant theme is development of nervous system and muscle tissues.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001843","count":9},{"id":"GO:0030900","count":8},{"id":"GO:0010832","count":7},{"id":"GO:1900222","count":7},{"id":"GO:0010735","count":7}]},{"hash":"324205999796021155","title":"Clathrin-mediated Endocytosis and Cytoskeletal Regulation","description":"This cluster is enriched for clathrin-dependent endocytosis, microtubule-based movement, actin filament capping, and signaling processes (GTPase activity, tyrosine phosphorylation, TGF-beta response), with a few development terms likely reflecting broader roles in signaling and morphogenesis. The common thread is vesicle trafficking coupled to cytoskeletal dynamics that regulate cellular signaling and movement.","confidence":"Medium","size":13,"edges":14,"triangles":0,"max_degree":4,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0072583","count":3},{"id":"GO:0021510","count":3},{"id":"GO:0071560","count":3},{"id":"GO:0007018","count":3},{"id":"GO:0051016","count":3}]},{"hash":"1761986631475752650","title":"Unknown","description":"The GO terms span development (cerebral cortex and glomerulus development), immune regulation (B cell homeostasis), detox/stress responses (response to xenobiotic stimulus, cellular response to alkaloid), DNA repair (base-excision repair), and cell-cycle signaling (peptidyl-threonine phosphorylation, positive regulation of G1/S transition). There is no single cohesive function that ties these together, suggesting multifunctional or diverse roles rather than a specific pathway or process. Therefore a concise, representative label cannot be determined beyond Unknown.","confidence":"","size":13,"edges":21,"triangles":4,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":4},{"id":"GO:0021987","count":3},{"id":"GO:0001782","count":3},{"id":"GO:0032835","count":3},{"id":"GO:0018107","count":3}]},{"hash":"394339223415101751","title":"Meiosis spindle assembly and ubiquitin-dependent proteolysis","description":"Top GO terms cluster around meiosis and cell-cycle control (oocyte maturation, spindle assembly in female meiosis I, DNA damage checkpoint signaling) and, separately, ubiquitin pathways (protein polyubiquitination, ubiquitin-dependent proteolysis) as well as microtubule polymerization. Together, they suggest a function in meiotic spindle assembly and proteostasis via ubiquitin-mediated degradation.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":8},{"id":"GO:0071276","count":6},{"id":"GO:0042752","count":6},{"id":"GO:0001556","count":6},{"id":"GO:0071406","count":6}]},{"hash":"1747096537023525644","title":"Neural development and synaptic signaling","description":"The top GO terms are dominated by neural-related processes: excitatory postsynaptic potential, long-term synaptic potentiation, axonogenesis, Schwann cell development, and visual perception, suggesting a cluster of proteins involved in neural development and synaptic function. Some terms such as cell cycle and abscisic acid signaling appear as outliers or cross-species annotations, but the overall theme centers on neural signaling and development.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":8},{"id":"GO:0014044","count":8},{"id":"GO:0043065","count":8},{"id":"GO:0010800","count":8},{"id":"GO:0060291","count":8}]},{"hash":"1705799639449339504","title":"Muscle, Heart, and Neural Signaling Regulation","description":"These proteins cluster around regulation of signaling and cellular responses, including kinase activity and phosphorylation, DNA binding regulation, and various organismal responses (insulin secretion, xenobiotic response, calcium-mediated cardiac contraction, axonogenesis, and neural-related stimuli). The shared theme is modulation of signaling pathways across muscle, heart, and nervous system, rather than a single specific pathway.","confidence":"Medium","size":13,"edges":47,"triangles":96,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010800","count":10},{"id":"GO:0035774","count":10},{"id":"GO:0043388","count":10},{"id":"GO:0014718","count":10},{"id":"GO:0035690","count":10}]},{"hash":"5403503088710388","title":"Thermosensory and nociceptive signaling","description":"The cluster is dominated by GO terms for sensory perception of pain and temperature response, plus membrane potential regulation and calcium signaling, suggesting neural signaling and thermosensation; some retina development and immune-related terms are present but less central to the main theme.","confidence":"High","size":13,"edges":4,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":13},{"id":"GO:0002024","count":13},{"id":"GO:0071502","count":13},{"id":"GO:0042391","count":10},{"id":"GO:0043311","count":9}]},{"hash":"1819752157950945866","title":"Cerebellar morphogenesis and caveolin-mediated trafficking","description":"The cluster is dominated by terms related to neural tissue development, especially cerebellum morphogenesis, animal organ morphogenesis, and neuron projection development, suggesting a role in neural formation. Concurrently, multiple terms point to membrane trafficking and remodeling, including caveolin-mediated endocytosis, plasma membrane tubulation, and transcytosis, indicating a coordinated membrane dynamic during morphogenesis. Some signaling responses appear (e.g., to cholecystokinin, interleukin-7), but they do not outweigh the core themes of development and trafficking.","confidence":"High","size":13,"edges":38,"triangles":46,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0061847","count":11},{"id":"GO:0051282","count":11},{"id":"GO:0072584","count":11},{"id":"GO:0098761","count":11},{"id":"GO:0010976","count":11}]},{"hash":"972530898197050118","title":"Developmental Signaling Across Tissues","description":"The top GO terms point to developmental processes in multiple tissues (heart, spinal cord, germ cells, B cells) and to regulation of signaling cascades (Rho, JNK) and neural functions (synaptic vesicle recycling). The cluster seems to group proteins involved in coordinating development with signaling control across various cell types, rather than a single pathway or tissue.","confidence":"Medium","size":13,"edges":14,"triangles":1,"max_degree":6,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0010765","count":11},{"id":"GO:0007507","count":9},{"id":"GO:0061000","count":9},{"id":"GO:0035023","count":9},{"id":"GO:0002344","count":8}]},{"hash":"239920279950221518","title":"RNA processing and translation initiation control","description":"The cluster shows strong enrichment for mRNA processing (splicing via spliceosome, polyadenylation, mRNA stability in stress) and broad involvement in translation initiation and reinitiation (preinitiation complex formation, IRES-dependent initiation, viral termination-reinitiation), suggesting a cohesive role in RNA metabolism and translational regulation.","confidence":"High","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":10},{"id":"GO:0006378","count":10},{"id":"GO:0010610","count":9},{"id":"GO:0048026","count":9},{"id":"GO:0031047","count":9}]},{"hash":"2043294581802276755","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":19,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":8},{"id":"GO:0090162","count":6},{"id":"GO:0035641","count":6},{"id":"GO:0035418","count":6},{"id":"GO:1903760","count":6}]},{"hash":"1741415045065928269","title":"Neural development and cytoskeleton organization","description":"The top terms are dominated by nervous system/brain development (GO:0007399, GO:0007420) and cytoskeletal components (GO:0007021), suggesting a coordinated role in neural development and neuronal structure. Additional terms for ER-to-Golgi transport and cell polarity imply supportive secretory and epithelial organization contexts that often accompany neural tissue development. Overall, these processes point to a neural development program with cytoskeletal and trafficking elements.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:1904263","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007420","count":3}]},{"hash":"481448547814735880","title":"Polyamine biosynthesis and transport","description":"The strongest signals in the cluster are polyamine-related: putrescine and spermidine biosynthesis, and positive regulation of polyamine transport, indicating a core theme of polyamine metabolism and its cellular transport. Secondary terms include Golgi network organization and phosphorylation, but the central function appears to be polyamine biosynthesis and movement across membranes.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033387","count":4},{"id":"GO:0045312","count":4},{"id":"GO:1902269","count":4},{"id":"GO:0098629","count":4},{"id":"GO:0009089","count":4}]},{"hash":"953783298739675561","title":"Steroid and sphingolipid biosynthesis","description":"The cluster is dominated by steroid and sphingolipid biosynthesis terms (testosterone, glucocorticoids, sphingolipids, 3-keto-sphinganine) and other lipid biosynthesis pathways (very long-chain fatty acids, poly-hydroxybutyrate), suggesting a cohesive lipid and steroid metabolism theme driving this protein group.","confidence":"High","size":13,"edges":55,"triangles":108,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":11},{"id":"GO:0006729","count":10},{"id":"GO:0061370","count":10},{"id":"GO:0006666","count":10},{"id":"GO:0030148","count":10}]},{"hash":"1184668395075454957","title":"Neuronal synapse development and signaling","description":"Dominant terms center on synapse-related processes\u2014receptor clustering, protein localization to synapse, and neural signaling in Purkinje cell pathways\u2014suggesting a cluster of genes involved in neuronal synapse development and function; other developmental terms are present but less central.","confidence":"Medium","size":13,"edges":8,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043113","count":4},{"id":"GO:0090179","count":3},{"id":"GO:2000821","count":3},{"id":"GO:0021937","count":2},{"id":"GO:0008585","count":2}]},{"hash":"1916943555879516816","title":"Neural development and myelination","description":"The top GO terms point to nervous system development, axonal fasciculation, and myelination, along with signaling pathways (Rho regulation, PI3K, erythropoietin, VEGF/PDGFR) that drive neural differentiation and cytoskeletal remodeling. This combination suggests a cluster of proteins involved in neuronal development and myelin formation rather than unrelated processes.","confidence":"High","size":13,"edges":3,"triangles":1,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:2000830","count":6},{"id":"GO:0043552","count":6},{"id":"GO:0038162","count":6},{"id":"GO:0038091","count":6}]},{"hash":"60469605728046873","title":"Neural development and cell adhesion","description":"These proteins cluster around nervous system development, synapse assembly, and glial/oligodendrocyte lineage regulation; several terms emphasize cell-cell adhesion (homophilic and heterophilic) which is critical for neural connectivity. While there are a few outlier terms related to other developmental processes (ossification, follicle cell microvilli), the strongest and most frequent signals point to neural development and adhesion, justifying a label that emphasizes neuronal differentiation and synaptic organization.","confidence":"Medium","size":13,"edges":66,"triangles":175,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":6},{"id":"GO:0007156","count":6},{"id":"GO:0007157","count":6},{"id":"GO:0051965","count":5},{"id":"GO:0043931","count":5}]},{"hash":"28845857636303542","title":"Craniofacial development and ECM remodeling","description":"The terms cluster around palate (roof of mouth) development, collagen fibril organization, and wound healing-related activities (keratinocyte migration, epidermal repair), supported by proteolysis for tissue remodeling and hypoxiaResponse in healing. Some terms (fertilization, peptidoglycan catabolic) may be less connected, but the overall theme is craniofacial morphogenesis and extracellular matrix remodeling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0007338","count":4},{"id":"GO:0097156","count":4},{"id":"GO:0060021","count":4},{"id":"GO:0001666","count":3}]},{"hash":"1508870826225510494","title":"Neural development and synapse assembly","description":"The cluster shows strong representation of nervous system development, inner ear development, and multiple facets of synaptic connectivity (synapse assembly, neuron cell-cell adhesion, glutamatergic transmission, and positive regulation of synapse assembly), plus corticospinal tract morphogenesis and calcium signaling. Together these terms point to roles in neural development and establishment of synaptic connections rather than a single isolated process. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0048839","count":6},{"id":"GO:0007156","count":6},{"id":"GO:0007399","count":5},{"id":"GO:0010838","count":5},{"id":"GO:0007416","count":5}]},{"hash":"1468270611935524257","title":"Organ Development Signals","description":"The top terms cluster around organ development (heart, retina, lung connective tissue, endothelial barrier) and related signaling (adenylate cyclase activation, calcium signaling), indicating proteins involved in developmental processes across tissues rather than a single pathway. A few terms relate to immune cell activity, which can intersect developmental signaling, but the primary motif is multiorgan development.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008542","count":10},{"id":"GO:0040015","count":10},{"id":"GO:0043311","count":9},{"id":"GO:0060427","count":9},{"id":"GO:0070963","count":9}]},{"hash":"596917632640520257","title":"Innate immune response and inflammation signaling","description":"The top GO terms cluster around innate immune functions: positive regulation of eosinophil degranulation, positive regulation of neutrophil\u2013mediated killing of Gram-negative bacteria, dendritic cell chemotaxis, and response to lipopolysaccharide, indicating a shared theme of innate immune sensing and inflammatory effector activity. While there are tissue development terms (lung connective tissue, retina, heart) and endothelial barrier regulation included, the strongest signal across the terms is immune activation and inflammatory signaling.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":13},{"id":"GO:0060427","count":13},{"id":"GO:0070963","count":13},{"id":"GO:0051482","count":13},{"id":"GO:0060041","count":13}]},{"hash":"1059122170409777718","title":"Neural signaling and ion transport","description":"Most terms point to neuronal function: gamma-aminobutyric acid signaling, light-detection in vision, locomotory behavior, and conditioned taste aversion. Additionally, sodium and potassium ion transmembrane transport reinforce an ion-channel/nerve signaling theme. Some terms (MAPK activation, defense against bacteria, bone ossification) seem less connected and may reflect multifunctional proteins or annotation noise. Overall, the dominant theme is neural signaling coupled with ion transport.","confidence":"Medium","size":13,"edges":8,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000187","count":8},{"id":"GO:0042742","count":7},{"id":"GO:0043931","count":6},{"id":"GO:0007214","count":5},{"id":"GO:0035725","count":5}]},{"hash":"766563243911518281","title":"MAPK signaling in neural development","description":"The top GO terms emphasize positive regulation of ERK1/2 and JNK cascades (MAPK pathways) and neural development processes such as nervous system development, hippocampus development, and axon extension. While a few terms touch on immune or thymocyte processes, the strongest and most frequent signals point to MAPK-driven neural development and axon growth, suggesting these proteins act in MAPK-regulated neural differentiation. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":12},{"id":"GO:0043552","count":12},{"id":"GO:0031532","count":12},{"id":"GO:0007399","count":12},{"id":"GO:0021766","count":12}]},{"hash":"111196943594759134","title":"Transcriptional Regulators in Development and Immunity","description":"The terms point to regulation of DNA-templated transcription as a central function, with multiple development-related terms (spinal cord, neuron projection, lens fiber, muscle) and immune signaling (MyD88-dependent TLR4, chemokine production). This pattern suggests proteins that regulate gene expression during diverse developmental processes and immune responses, possibly including chromatin-modifying activities. The broad developmental context plus transcriptional control makes a cohesive, high-level label appropriate.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0021510","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0035660","count":2},{"id":"GO:0007527","count":2}]},{"hash":"380057847696882301","title":"Unknown","description":"These proteins show neuronal development signals (neuron projection morphogenesis; nervous system development) alongside a variety of unrelated metabolic and transport processes (Golgi to plasma membrane protein transport; menaquinone, strigolactone, and poly-hydroxybutyrate biosynthesis; triglyceride catabolic process; C-terminal demethylation). The GO terms do not point to a single cohesive function for the cluster, so the safe label is Unknown.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048812","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0043001","count":2},{"id":"GO:0009234","count":1},{"id":"GO:0019433","count":1}]},{"hash":"502509849999842260","title":"Mitosis: Chromosome Segregation and Nuclear Transport","description":"This cluster centers on mitotic and meiotic chromosome segregation (mitotic/meiotic sister chromatid separation and cohesion) and nuclear transport/assembly processes (nuclear pore complex assembly, mitotic nuclear membrane reassembly, ribosomal protein import into the nucleus), pointing to a shared function in coordinating chromosome handling with nuclear transport during cell division. Additional terms related to GTPase regulation, desumoylation, TORC1 signaling, STAT phosphorylation, and apoptotic morphogenesis likely reflect broader regulatory layers that modulate these core processes.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0060188","count":6},{"id":"GO:0051306","count":6},{"id":"GO:0051292","count":6},{"id":"GO:0051754","count":6}]},{"hash":"481441770826280797","title":"Organ Development and Cell-Cell Adhesion","description":"This cluster shows enrichment for broad developmental processes across multiple organs (multicellular organism development, heart, kidney, bone ossification, nervous system) and cell\u2013cell adhesion, including heterophilic adhesion and synapse assembly, suggesting a theme of tissue morphogenesis and connectivity. Immune-related terms (innate immune response, classical complement activation) may reflect pleiotropic or regulatory roles during development.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007275","count":7},{"id":"GO:0051965","count":7},{"id":"GO:0006958","count":7},{"id":"GO:0007157","count":7},{"id":"GO:0007399","count":6}]},{"hash":"279320923137300775","title":"Neuronal signaling and synapse maturation","description":"This cluster is driven by GO terms linked to neuronal function: synapse maturation, cellular response to electrical stimulus, regulation of dopamine receptor signaling, and regulation of cell shape and filopodium assembly, all pointing to neuronal signaling and synapse development. Some terms like kidney development and certain immune regulators appear, but the dominant signal centers on neuronal/synaptic processes.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":2},{"id":"GO:0045404","count":2},{"id":"GO:0045590","count":2},{"id":"GO:0007194","count":2},{"id":"GO:0051491","count":2}]},{"hash":"147737173419974372","title":"Developmental proliferation and signaling","description":"This cluster centers on tissue development and cell proliferation, with terms for spinal cord, skin, and retina development, plus positive regulation of cell population proliferation. It also includes signaling-related terms (transforming growth factor beta stimulus, TORC1 signaling) and cytoskeletal regulation (negative regulation of Arp2/3\u2013mediated actin nucleation), suggesting a cohesive theme of developmentally driven growth coordinated by signaling and cytoskeletal dynamics. Some outliers (cadmium response, histone acetylation) exist, but the dominant signal is developmental proliferation linked to signaling pathways.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0021510","count":1},{"id":"GO:0071560","count":1},{"id":"GO:0071276","count":1}]},{"hash":"1318080145901299432","title":"Mitochondrial fission and apoptotic regulators","description":"The top terms are dominated by mitochondrial fission and apoptotic signaling (positive regulation of mitochondrial fission; regulation of mitochondrial outer membrane permeabilization; apoptotic process), with additional development and immune-related terms (multicellular organism development; eye development; inflammatory response; T cell chemotaxis). This pattern suggests the cluster mainly comprises regulators of mitochondria-dependent apoptosis, likely with broader roles in development and immune signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090141","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0006954","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0090314","count":2}]},{"hash":"1902484565263518537","title":"Mitochondrial gene expression and ribosome assembly","description":"The top GO terms cluster around mitochondria, including mitochondrial ribosome assembly, mitochondrial transcription, and regulation of mitochondrial transcription, indicating a cohesive core function in mitochondrial gene expression. A few outlier terms related to mitosis and organelle organization exist, but they do not outweigh the central mitochondrial signal. ","confidence":"Medium","size":12,"edges":43,"triangles":61,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0061668","count":2},{"id":"GO:0007077","count":1},{"id":"GO:0015074","count":1},{"id":"GO:0045071","count":1},{"id":"GO:0075713","count":1}]},{"hash":"300723249820797960","title":"Ribosome/translation machinery cluster","description":"This cluster is dominated by the translation GO term (GO:0006412) with six proteins, suggesting ribosomal components or translation factors as the core. A few other terms point to iron-sulfur cluster biology and protein maturation, which may reflect ancillary roles or annotation noise, and an isolated antibiotic response signal that aligns with ribosome-targeting antibiotics. Overall, the primary theme appears to be translation machinery with some Fe-S related associations.","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0046677","count":3},{"id":"GO:0034396","count":1},{"id":"GO:0036086","count":1},{"id":"GO:0044571","count":1}]},{"hash":"640469754358148139","title":"Cytoskeleton-Directed Vesicle Transport and Mitosis","description":"This cluster is best described by shared involvement in microtubule-guided vesicle transport and cytoskeletal organization that accompanies cell division. The prominent GO terms include plus-end\u2013directed vesicle transport along microtubules, establishment of microtubule polarity, ER-to-Golgi transport, and mitotic metaphase chromosome alignment, all pointing to coordinated trafficking and chromosomal segregation during mitosis. Other terms like stress granule disassembly and root development appear less central but don't override the core theme of cytoskeleton-based transport during division.","confidence":"Medium","size":12,"edges":47,"triangles":90,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0035617","count":5},{"id":"GO:0048364","count":5},{"id":"GO:0015991","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0006888","count":3}]},{"hash":"575750295687000847","title":"Mitochondrial respiration and dynamics","description":"This cluster centers on mitochondrial energy production and membrane regulation. The prominent GO terms include mitochondrial electron transport (ubiquinol to cytochrome c), aerobic respiration, proton transmembrane transport, and ADP/phosphate transport\u2014core components of oxidative phosphorylation. Additional terms point to mitochondrial membrane potential regulation and membrane permeability, as well as mitochondrial fission and iron import, reflecting maintenance and biogenesis functions. The overlap with negative regulation of necroptotic processes ties to mitochondrial control of cell death pathways. Together, these terms indicate a cohesive theme of mitochondrial energy metabolism and structural-dynamic maintenance.","confidence":"High","size":12,"edges":21,"triangles":13,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1902600","count":4},{"id":"GO:0046902","count":4},{"id":"GO:0060546","count":4},{"id":"GO:0051881","count":4},{"id":"GO:0006122","count":3}]},{"hash":"1879566861895046774","title":"TGF-\u03b2/SMAD signaling regulation","description":"Dominant enrichment for TGF-\u03b2 pathway signals (response to TGF-\u03b2, negative regulation of TGF-\u03b2 receptor signaling, SMAD-related regulation) with supporting phosphorylation/dephosphorylation steps; a few unrelated terms appear but overall the cluster aligns with TGF-\u03b2/SMAD signaling modulation.","confidence":"Medium","size":12,"edges":45,"triangles":91,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046827","count":8},{"id":"GO:0071560","count":6},{"id":"GO:0030512","count":6},{"id":"GO:0000173","count":5},{"id":"GO:0035970","count":5}]},{"hash":"717667046776143011","title":"Mitochondrial lipid biosynthesis and remodeling","description":"The top GO terms are dominated by lipid biosynthesis/remodeling processes (triglyceride, ether lipid, CDP-diacylglycerol, cardiolipin, and phosphatidylcholine remodeling) along with mitochondrial ATP synthesis tied to electron transport, pointing to a lipid metabolism and mitochondrial membrane context. A few terms related to immune regulation or glandular maturation appear incidental rather than central to this cluster. Confidence: High","confidence":"","size":12,"edges":36,"triangles":35,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0019432","count":11},{"id":"GO:0008611","count":11},{"id":"GO:0010143","count":11},{"id":"GO:0042775","count":11},{"id":"GO:0035965","count":11}]},{"hash":"502524486831606428","title":"RNA and protein methylation enzymes","description":"The top GO terms are heavily centered on methylation activities: RNA methylation (tRNA, rRNA, guanine-N7), tRNA wobble uridine modification, mRNA cap methylation, and peptidyl-arginine methylation, plus a transcription-related term. This pattern points to a cluster enriched for methyltransferase enzymes acting on RNA and proteins, with secondary links to transcription and cofactor-related processes, making \u201cRNA and protein methylation enzymes\u201d the most coherent label.","confidence":"High","size":12,"edges":55,"triangles":137,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030488","count":7},{"id":"GO:0009236","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0031167","count":6},{"id":"GO:0002098","count":6}]},{"hash":"2195025089631837675","title":"Ribosome biogenesis and translation; NMJ synapse assembly","description":"The top GO terms cluster around ribosome biogenesis (small/large subunit processes, export) and cytoplasmic translation, indicating a core focus on protein synthesis machinery. There are accompanying signals for endoplasmic reticulum organization and NMJ synapse assembly, suggesting additional neuronal/glial synaptic context, but the dominant theme is ribosome biogenesis and translation.","confidence":"Medium","size":12,"edges":19,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007029","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0042274","count":2},{"id":"GO:0002181","count":2}]},{"hash":"2149980814518808347","title":"Unknown","description":"The top GO terms span disparate biological contexts (plant stomatal movement and ABA biosynthesis; chloroplast protein import; molybdenum cofactor biosynthesis; autophagy regulation; heat response; pigment and neural development), with an obsolete mitochondrion morphogenesis term and an insect pigment term alongside plant-specific processes. This mixture suggests no single coherent function tying all proteins together, so a specific label is not justifiable. ","confidence":"","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070584","count":3},{"id":"GO:0006777","count":2},{"id":"GO:0016242","count":2},{"id":"GO:0009408","count":2},{"id":"GO:0010118","count":1}]},{"hash":"2219929101954510547","title":"Unfolded Protein Response and ER Stress","description":"These proteins cluster around ER protein quality control: responses to unfolded proteins, chaperone-assisted refolding, ER-associated degradation, and translation regulation during ER stress, with supporting links to heat-shock handling and misfolded protein transport. This cohesive set points to a core ER stress/UPR function.","confidence":"High","size":12,"edges":11,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006986","count":3},{"id":"GO:0070389","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0036494","count":3},{"id":"GO:0006469","count":2}]},{"hash":"1399508037504338736","title":"Ribosome biogenesis and translation","description":"This cluster is enriched for translation, ribosome biogenesis, rRNA maturation, and tRNA aminoacylation, pointing to a shared role in ribosome production and protein synthesis. The presence of translational fidelity and initiation regulation terms further supports a focus on accurate translation, with antibiotic response possibly reflecting ribosome-targeting pathways.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0000462","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0031564","count":3},{"id":"GO:0006351","count":3}]},{"hash":"2269620337085930396","title":"Unknown","description":"The terms show multiple, diverse biological themes (mitochondrial energy production/biogenesis, proteoglycan biosynthesis, developmental morphogenesis, plant flavonoid metabolism) with no single dominant function linking the proteins. With no edges and only scattered, weakly connected GO terms, there isn't a coherent common theme to define a meaningful label.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061179","count":1},{"id":"GO:0042775","count":1},{"id":"GO:0030007","count":1},{"id":"GO:0070131","count":1},{"id":"GO:0042407","count":1}]},{"hash":"1768035828745754418","title":"Nuclear gene expression and DNA maintenance","description":"This cluster aggregates GO terms spanning transcription (DNA-templated transcription, transcription elongation), RNA processing and export (mRNA processing/export), DNA-related processes (DNA replication, DNA repair), ribosome biogenesis/translation, and cell division. These converging themes point to factors involved in safeguarding and expressing the genome\u2014from transcription through mRNA handling to translation and genome maintenance\u2014so the name captures the core nuclear gene expression and genome upkeep functions. The retinal ganglion cell axon guidance term appears to be an outlier or annotation artifact. ","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0006406","count":3},{"id":"GO:0000027","count":2}]},{"hash":"1597518029169654016","title":"MAPK signaling and actin remodeling in neurons","description":"The cluster is enriched for GO terms centered on signaling cascades (ERK1/ERK2 and JNK) and cytoskeletal changes (actin filament polymerization, pseudopodium assembly), which together point to MAPK-mediated signal transduction driving actin remodeling in neural contexts, supported by terms like brain development. Some terms also hint at broader cellular responsiveness ( xenobiotic response, chemotaxis ), but the dominant theme is MAPK signaling linked to actin dynamics in neurons.","confidence":"Medium","size":12,"edges":3,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":8},{"id":"GO:0043552","count":8},{"id":"GO:0046330","count":8},{"id":"GO:0031274","count":6},{"id":"GO:0002551","count":6}]},{"hash":"1405402586988178077","title":"Developmental and Immune Regulation Proteins","description":"This cluster features GO terms pointing to development across tissues (neuron projection development, lens fiber cell differentiation, skeletal system development) alongside immune system processes (innate and adaptive immune responses, negative regulation of immune signaling). The combination suggests proteins involved in developmental differentiation with immunoregulatory roles rather than a single pathway. An obsolete ERAD term appears as an outlier, possibly from historical annotation or multifunctionality. Overall, the label Developmental and Immune Regulation Proteins captures the broad theme, with moderate confidence.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0001501","count":2}]},{"hash":"1934878228700450046","title":"Ribosome biogenesis and cytoplasmic translation","description":"This cluster is dominated by GO terms tied to ribosome assembly and protein synthesis, including ribosomal small subunit biogenesis and cytoplasmic translation, plus export of ribosomal subunits from the nucleus, pointing to a cohesive function in ribosome production and function. Additional signals for cell growth such as cell cycle and cell division appear alongside, suggesting coordinated regulation of growth with translation; some other terms (neuron development, oxidation-reduction) are less central to the core theme. Overall, the primary pattern fits ribosome biogenesis and cytoplasmic translation.","confidence":"High","size":12,"edges":33,"triangles":37,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0010976","count":3},{"id":"GO:0045454","count":3},{"id":"GO:0042274","count":2},{"id":"GO:0002181","count":2}]},{"hash":"226452103646688202","title":"Epithelial morphogenesis and actin remodeling signaling","description":"The top terms center on actin filament bundle assembly, epithelial polarity, cell migration, and branching morphogenesis, with supporting small GTPase and EGFR signaling. This suggests coordinated cytoskeletal remodeling and signaling driving epithelial morphogenesis and movement, with immune-related terms playing a secondary role.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051017","count":7},{"id":"GO:0090162","count":7},{"id":"GO:0060670","count":7},{"id":"GO:0007173","count":7},{"id":"GO:0016477","count":7}]},{"hash":"117286822484022393","title":"Ribosome Biogenesis and Cell Cycle Coordination","description":"This cluster is dominated by GO terms for ribosome biogenesis and ribosomal subunit export from the nucleus, including ribosome assembly and tRNA modification, indicating a focus on the production and maturation of ribosomes. The presence of cell cycle-related terms (cell cycle, cell division, cell septum assembly) suggests these ribosome-related processes are coordinated with cell division. A few terms related to stress response regulation appear, but the core signal points to ribosome biogenesis linked to cell cycle progression.","confidence":"High","size":12,"edges":16,"triangles":0,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000055","count":10},{"id":"GO:0051301","count":10},{"id":"GO:0042254","count":9},{"id":"GO:0042274","count":9},{"id":"GO:1901001","count":9}]},{"hash":"988844424962116683","title":"Cerebellar development and signaling regulation","description":"This cluster centers on signaling pathways linked to cerebellar development, as evidenced by terms like cerebellar cortex formation and Bergmann glial cell differentiation, as well as regulation of axon regeneration and the ERK cascade. While there are also broader signaling terms (TLR3 and T cell receptor signaling, insulin signaling), these likely reflect general signaling regulation that can intersect neural development. Taken together, the dominant theme is cerebellar development with associated neural signaling control.","confidence":"Medium","size":12,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034141","count":6},{"id":"GO:0050852","count":6},{"id":"GO:0008286","count":5},{"id":"GO:0021697","count":5},{"id":"GO:0000200","count":5}]},{"hash":"938890801553885959","title":"Calcium-driven signaling and secretion across tissues","description":"The top GO terms point to calcium-dependent exocytosis, phosphorylation signaling (STAT), and hormone/cytokine pathways (erythropoietin, IL-7, PTH), along with processes like transcytosis and focal adhesion regulation. Together they suggest a cohesive theme of calcium- and phosphorylation-mediated signaling coordinating secretion and communication across neural, immune, and endocrine contexts. ","confidence":"Medium","size":12,"edges":23,"triangles":3,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051893","count":11},{"id":"GO:0007399","count":10},{"id":"GO:0045956","count":10},{"id":"GO:0098761","count":10},{"id":"GO:0042503","count":10}]},{"hash":"1614565104518531573","title":"Dopaminergic Reward Signaling and Drug Response","description":"The cluster is dominated by terms related to dopaminergic synaptic transmission and behavioral responses to drugs (morphine, cocaine), with ERK cascade regulation supporting neuronal signaling and plasticity. Additional terms point to sensory and visual processing and pain perception, suggesting a neural signaling module tied to reward and drug response. While a few terms reference non-neural contexts (heart development, brain renin-angiotensin system), the core pattern emphasizes brain dopaminergic signaling and drug-evoked behaviors.","confidence":"Medium","size":12,"edges":59,"triangles":160,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":10},{"id":"GO:0070374","count":10},{"id":"GO:0048148","count":10},{"id":"GO:0010759","count":10},{"id":"GO:0019233","count":10}]},{"hash":"1524604280023229409","title":"Immune receptor signaling inhibition and MAPK regulation","description":"Top GO terms show negative regulation of T cell receptor signaling and B cell receptor signaling, inhibition of the ERK1/ERK2 cascade, and reduced tyrosine phosphorylation of STAT proteins, complemented by regulatory roles in B cell differentiation and CD8 T cell proliferation. Additional terms point to unfolded protein response via IRE1 and lipid signaling (phosphoanandamide dephosphorylation). Together these terms suggest a module of proteins that attenuates adaptive immune signaling while also engaging stress-response pathways.","confidence":"High","size":12,"edges":19,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0000200","count":7},{"id":"GO:0070373","count":7},{"id":"GO:0050860","count":7},{"id":"GO:0050859","count":6},{"id":"GO:0035644","count":6}]},{"hash":"373188836755590416","title":"Neural development and myelination regulation","description":"The cluster\u2019s top GO terms center on neuron development and myelin-related processes (neuron development, myelin assembly, negative regulation of myelination) with supporting signaling and protein turnover terms (peptidyl-tyrosine dephosphorylation, negative regulation of proteasomal ubiquitin-dependent protein catabolic process). This suggests a cohesive theme around neural differentiation and the regulation of myelin formation/maintenance, aided by signaling phosphatases and proteostasis. Confidence: High","confidence":"","size":12,"edges":44,"triangles":72,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0048666","count":7},{"id":"GO:0032435","count":7},{"id":"GO:0035335","count":6},{"id":"GO:0046716","count":5},{"id":"GO:0051262","count":5}]},{"hash":"2058783136921803907","title":"Multitissue organogenesis","description":"The cluster shows enrichment across diverse tissue development and morphogenesis terms (ear, labyrinthine layer, mesenchyme, heart/kidney organogenesis, oligodendrocyte development, pancreatic cell fate), indicating a general developmental/organogenesis theme rather than a single tissue. This convergence supports labeling as multitissue organogenesis with high confidence.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0042491","count":12},{"id":"GO:0007540","count":12},{"id":"GO:0072277","count":12},{"id":"GO:0003253","count":12},{"id":"GO:0003329","count":12}]},{"hash":"1127850068442651037","title":"Chromatin remodeling and transcriptional regulation","description":"Most terms point to DNA-templated transcription and chromatin remodeling with epigenetic regulation (histone modification-related terms). Atrial septum morphogenesis terms are present but likely reflect co-annotated developmental processes; the dominant signal is transcription control through chromatin state.","confidence":"High","size":12,"edges":12,"triangles":2,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0000122","count":5},{"id":"GO:0043044","count":5},{"id":"GO:0003290","count":5},{"id":"GO:0045654","count":5}]},{"hash":"1162877524574289316","title":"Mitotic spindle assembly and cell division","description":"The terms cluster around mitosis and spindle dynamics: spindle pole body duplication, microtubule nucleation, cytoplasmic microtubule organization, and mitotic cytokinesis with spindle midzone assembly and overall cell division. A minor, non-dominant term for interleukin-4 response appears incidental. This set coherently reflects proteins involved in spindle function and cytokinesis during cell division.","confidence":"High","size":12,"edges":22,"triangles":14,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903087","count":8},{"id":"GO:0007020","count":8},{"id":"GO:0007049","count":6},{"id":"GO:0031122","count":5},{"id":"GO:0071353","count":5}]},{"hash":"1336711515375406715","title":"Ribosome biogenesis and translation initiation","description":"The cluster\u2019s top GO terms cluster around forming translation preinitiation complexes, translation reinitiation, and maturation of rRNA (5.8S and LSU), which together point to ribosome assembly and the start of protein synthesis. Some other terms (DNA repair/translesion synthesis and developmental signaling) appear peripheral, suggesting multifunctionality but not redefining the core theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0031954","count":3},{"id":"GO:0000466","count":3},{"id":"GO:0000463","count":3}]},{"hash":"1293392337253888581","title":"Regulation of signaling pathways","description":"These proteins collectively show links to diverse signaling processes: GPCR-related signaling and downstream kinase activity, positive regulation of GTPase and serine/threonine kinase activities, Wnt signaling, and even synapse assembly. While some terms touch on telomere maintenance, the unifying theme appears to be regulation of various cellular signaling cascades and their downstream effects, rather than a single pathway. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0048549","count":4},{"id":"GO:0031954","count":3},{"id":"GO:0071902","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1020613546915267617","title":"Neuronal development, axonogenesis, and myelination","description":"Dominant GO terms cluster around neural development and function, including positive regulation of axonogenesis, neuron\u2013cell adhesion, clustering of voltage-gated sodium channels, and myelination, indicating a role in neural differentiation and maintenance. Some terms reference tau-related pathways and neural pathology, while a few outliers (eye development, immune-related terms) are less central, but overall the theme supports neural development and myelination. ","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1902997","count":11},{"id":"GO:1901491","count":11},{"id":"GO:0030336","count":11},{"id":"GO:1902948","count":11},{"id":"GO:0050772","count":11}]},{"hash":"706440261415798694","title":"Heat-shock response and protein quality control","description":"The cluster centers on heat-related and proteostasis functions: several terms point to response to heat, unfolded/misfolded protein handling, and misfolded protein transport, with additional regulation of ATP-dependent activity and protein kinase activity that fit chaperone-mediated quality control. A minor outlier is DNA replication, which is not directly tied to proteostasis and may reflect background signals. Overall, the set suggests a coordinated heat-stress proteostasis module.","confidence":"High","size":12,"edges":11,"triangles":0,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0006469","count":3},{"id":"GO:0032781","count":3},{"id":"GO:1900035","count":3},{"id":"GO:0006452","count":3}]},{"hash":"1058268304378033551","title":"Unknown","description":"The listed GO terms cover a wide range of processes (retina development, NF-kappaB signaling, Golgi localization, mitosis, GPCR signaling, protein interactions, DNA repair, mitophagy, defense), with no single unifying function apparent for the entire protein set. Because there isn\u2019t a cohesive theme linking the cluster\u2019s functions, there is no clear, representative label.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0000042","count":2},{"id":"GO:0007064","count":2},{"id":"GO:0007200","count":2}]},{"hash":"1524614195538856043","title":"Embryonic Morphogenesis and Transcription Regulation","description":"The GO terms point to developmental gene regulation and morphogenesis across multiple organs (forelimb and digit formation, heart outflow tract, cerebral cortex development, pituitary, pulmonary veins) together with DNA-templated transcription and regulation of gene expression, suggesting a cluster of transcriptional regulators driving embryogenesis; cellular senescence appears in the list but is not central to the main theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0090398","count":3},{"id":"GO:0021796","count":3},{"id":"GO:0048706","count":3},{"id":"GO:0003148","count":3}]},{"hash":"718039551688702136","title":"Neural Development and Sensory Morphogenesis","description":"Dominant GO terms include midbrain development, cerebellar Purkinje cell signaling, and visual perception, indicating a neural development and sensory system focus. Additional terms on embryonic morphogenesis and regulation of signaling pathways support a broader developmental theme, though they are less specific to neurons. Overall, the core signal is neural development with sensory aspects, justifying this label with moderate confidence.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0007586","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0061296","count":3}]},{"hash":"2234181260463597503","title":"Plant development, RNA processing, and proteostasis","description":"The Top Terms include plant-specific processes (stamen formation, chlorophyll biosynthetic process) alongside RNA metabolism (negative regulation of miRNA processing, poly(A) tail shortening) and protein turnover (ubiquitin-dependent proteolysis, proteasome assembly). This suggests a theme around plant growth/differentiation tied to regulation at RNA and protein levels, rather than a single tight function. The lack of edges supports a broader, multi-faceted cluster. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0010288","count":2},{"id":"GO:1903799","count":2},{"id":"GO:0048455","count":2},{"id":"GO:0015995","count":2}]},{"hash":"311103395587724782","title":"Immune-vascular development and inflammation","description":"The cluster centers on immune-related processes (regulation of eosinophil degranulation, neutrophil-mediated killing, dendritic cell chemotaxis, response to lipopolysaccharide) alongside developmental and vascular-related terms (lung connective tissue development, heart development, retina development, endothelial barrier regulation). This suggests proteins that link immune signaling with tissue and vascular development, possibly reflecting coordinated inflammatory and organogenesis programs.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":12},{"id":"GO:0060427","count":12},{"id":"GO:0070963","count":12},{"id":"GO:0051482","count":12},{"id":"GO:0060041","count":12}]},{"hash":"1064965170338198698","title":"Immune response and tissue development","description":"The top GO terms span immune processes (eosinophil degranulation, neutrophil killing of gram-negative bacteria, dendritic cell chemotaxis, response to LPS) and tissue/organ development (lung connective tissue development, heart development, retina development, endothelial barrier regulation). The combination suggests proteins involved in inflammatory signaling with ties to developmental/vascular contexts, rather than a single cohesive pathway. Hence the label reflects both immune activation and developmental/tissue aspects.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":11},{"id":"GO:0060427","count":11},{"id":"GO:0070963","count":11},{"id":"GO:0051482","count":11},{"id":"GO:0060041","count":11}]},{"hash":"343071075676295044","title":"Negative regulation of signaling and endosomal trafficking","description":"The cluster\u2019s top terms center on negative regulation across signaling pathways (NF-kappaB, TNF, HIF-1alpha) and on membrane trafficking steps (plasma membrane to endosome transport, endosome maturation). There are also development terms (forebrain, lung morphogenesis), suggesting regulatory proteins that influence signaling and vesicular trafficking across contexts rather than a single enzymatic function. This supports a high-level label capturing regulatory roles in signaling and endosomal transport.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":1},{"id":"GO:1902072","count":1},{"id":"GO:0033209","count":1},{"id":"GO:1902306","count":1},{"id":"GO:2000009","count":1}]},{"hash":"1968295958545578555","title":"Immune Signaling and Cardiac Conduction","description":"The top GO terms are dominated by immune-related processes: complement activation via the classical pathway, immunoglobulin production, neutrophil extravasation, and regulation of NK cell-mediated cytotoxicity, along with cell adhesion. These together suggest a functional cluster centered on immune activation and leukocyte trafficking, with adhesion molecules facilitating interactions among immune cells and endothelial barriers. A subset of terms also points to cardiac electrophysiology (SA node action potential, heart rate regulation, and atrial/ventricular membrane depolarization/repolarization), which may reflect dual roles of some proteins in inflammation-linked cardiac function or shared regulatory pathways. Overall, the cluster appears to integrate immune signaling with components relevant to cardiac conduction, hence the combined label.","confidence":"Medium","size":12,"edges":34,"triangles":24,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":7},{"id":"GO:0007156","count":6},{"id":"GO:0007157","count":6},{"id":"GO:0002377","count":6},{"id":"GO:0060371","count":6}]},{"hash":"1074884743127452720","title":"Neuro-immune development and immune regulation","description":"The terms point to neural development (axon guidance, neuron projection development, nervous system development) alongside diverse immune functions (regulation of NK and T cell activity, dendritic cell differentiation, ADCC, inflammatory wound healing). This suggests proteins involved in neural development that also modulate immune responses, indicating neuro-immune cross-talk or shared regulatory components.","confidence":"Medium","size":12,"edges":15,"triangles":6,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007411","count":7},{"id":"GO:0002859","count":7},{"id":"GO:0007399","count":7},{"id":"GO:1904604","count":7},{"id":"GO:0071639","count":7}]},{"hash":"1152468658879144167","title":"Cardiovascular Development and Immune Signaling","description":"The top GO terms point to organ and tissue development (heart, retina, lung connective tissue) and vascular-related processes (endothelial barrier regulation), alongside multiple immune-related activities (eosinophil degranulation, neutrophil killing, dendritic cell chemotaxis, LPS response) and GPCR/cAMP signaling. This suggests a cluster of proteins involved in developmental programs of cardiovascular/vascular tissues with modulation of innate immune signaling, rather than a single cohesive pathway. Confidence: Medium","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":12},{"id":"GO:0060427","count":12},{"id":"GO:0070963","count":12},{"id":"GO:0051482","count":12},{"id":"GO:0060041","count":12}]},{"hash":"677073451133041852","title":"Nucleotide biosynthesis and DNA synthesis","description":"The top GO terms point strongly to formation and salvage of nucleotides (deoxyribonucleoside monophosphate biosynthesis, dGTP metabolism, pyrimidine and deoxyguanosine salvage, TMP biosynthesis) and the broader \u201cDNA biosynthetic process.\u201d A few terms touch on energy metabolism (mitochondrial electron transport) and a PHB biosynthesis term as a possible outlier, but the dominant pattern is nucleotide metabolism and DNA precursor synthesis.","confidence":"High","size":11,"edges":4,"triangles":1,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0016310","count":4},{"id":"GO:0042619","count":4},{"id":"GO:0006180","count":3},{"id":"GO:0006230","count":3}]},{"hash":"402368707456060414","title":"Unknown","description":"The top terms include translation, iron-sulfur cluster assembly, protein maturation, and various organ/tissue development processes, with no clear, single functional theme linking all proteins. The mix of unrelated processes suggests no coherent cluster function can be inferred.","confidence":"","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006880","count":1},{"id":"GO:0009399","count":1},{"id":"GO:0016226","count":1},{"id":"GO:0051604","count":1}]},{"hash":"933429166608821808","title":"Organ development and epithelial transport","description":"This cluster seems to group proteins involved in organ development and epithelial transport/secretion, including kidney development and morphogenesis, epithelial morphogenesis, and transport regulation (chloride and dipeptide transport), suggesting a link between developmental processes and membrane transport functions.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":4},{"id":"GO:0055010","count":3},{"id":"GO:0046903","count":2},{"id":"GO:0070445","count":2},{"id":"GO:2001225","count":2}]},{"hash":"810590116694731618","title":"Zinc Ion Homeostasis and Transport","description":"The GO terms are dominated by zinc-related processes: detoxification, intracellular homeostasis, cellular response to zinc starvation, and zinc import across membranes, plus a related metal ion transport term. This suggests a cohesive theme of zinc handling and transport, with a couple of outliers (limb development and N-terminal acetylation) that are not core to the cluster. ","confidence":"High","size":11,"edges":11,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0010312","count":3},{"id":"GO:0006882","count":3},{"id":"GO:0034224","count":3},{"id":"GO:0044749","count":3},{"id":"GO:1903615","count":3}]},{"hash":"988993159763398671","title":"RNA processing and transcription regulation","description":"Based on the top GO terms, this cluster centers on regulation of gene expression at RNA and transcription levels: several terms involve transcription processes (DNA-templated transcription, transcription antitermination, and termination regulation) and RNA processing/decay (pre-miRNA processing, miRNA catabolic process, mRNA stabilization). A minority of terms touch metabolic or stress-related pathways (glycolysis, TCA cycle, osmotic-stress\u2013related apoptosis), likely reflecting broad cellular homeostasis rather than a single pathway. Overall, the cluster appears enriched for RNA processing and transcription control functions.","confidence":"High","size":11,"edges":15,"triangles":5,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070934","count":4},{"id":"GO:0031564","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0010587","count":4},{"id":"GO:1902219","count":4}]},{"hash":"239311744172255398","title":"T cell activation and actin remodeling","description":"This cluster centers on immune signaling tied to rapid actin cytoskeleton remodeling. Enriched terms include innate and inflammatory responses, regulation of GTPase activity, actin crosslinking and microspike assembly, cell polarity and adhesion, and IL-2 production, which together point to activated T cells reorganizing their cytoskeleton for immune synapse formation and movement.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0006954","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0051764","count":2},{"id":"GO:0051666","count":2}]},{"hash":"170395395793137918","title":"Complement-Platelet-Immune Signaling","description":"This cluster is dominated by terms related to the complement system (complement activation, lectin pathway; complement receptor signaling) and mechanisms of leukocyte adhesion and platelet activation, suggesting a theme of immune and hemostatic communication. Some terms appear less connected (e.g., thyroid hormone generation), but the core signals point to complement-mediated immune and platelet interactions.","confidence":"High","size":11,"edges":20,"triangles":13,"max_degree":9,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0039573","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0050901","count":6},{"id":"GO:0010572","count":6},{"id":"GO:0060074","count":6}]},{"hash":"2124077082516812436","title":"Vesicle trafficking and fertilization-related exocytosis","description":"The top GO terms are dominated by vesicle trafficking and membrane fusion: acrosomal vesicle exocytosis and the fusion of sperm to the egg plasma membrane, plus endocytosis, which together point to membrane trafficking processes. While other terms (glycogen metabolism, neural tube closure, negative regulation of muscle differentiation, etc.) are present, they are less cohesive with the vesicle trafficking theme. Therefore, a concise label capturing the core function is vesicle trafficking with fertilization-related exocytosis.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0005977","count":2},{"id":"GO:0007342","count":1},{"id":"GO:0060478","count":1},{"id":"GO:0006897","count":1},{"id":"GO:0001843","count":1}]},{"hash":"1289366927277516596","title":"Mitochondrial dynamics and apoptotic regulation","description":"The top GO terms cluster around mitochondrial membrane fission and fusion, including fragmentation in the apoptotic process, which points to roles in shaping mitochondria and regulating cell death. Additional terms related to regulation of intrinsic apoptosis, ROS metabolism, and immune signaling (interferon-beta response) suggest a broader mitochondrial stress response involvement. Overall, this cluster likely represents proteins coordinating mitochondrial morphology with apoptotic signaling and stress responses.","confidence":"High","size":11,"edges":10,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0090149","count":2},{"id":"GO:0008053","count":2},{"id":"GO:0043653","count":2},{"id":"GO:0000002","count":2},{"id":"GO:0070584","count":2}]},{"hash":"1308402708139505892","title":"TGF-\u03b2/SMAD signaling regulation","description":"The cluster's top GO terms emphasize cellular response to transforming growth factor beta, negative regulation of TGF-\u03b2 receptor signaling, SMAD complex regulation, and related dephosphorylation and nuclear export processes, indicating a shared role in modulating TGF-\u03b2 signaling pathway activity.","confidence":"High","size":11,"edges":14,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":5},{"id":"GO:0000173","count":4},{"id":"GO:0035970","count":4},{"id":"GO:0010074","count":4},{"id":"GO:0030512","count":4}]},{"hash":"1203176666557539829","title":"RNAP II Transcription Regulation","description":"The cluster shows a clear emphasis on transcription-related GO terms, notably DNA-templated transcription and negative regulation of transcription by RNA polymerase II, indicating a transcriptional regulatory focus. While lipid metabolism terms appear, they are less consistent with the dominant transcription theme, so a label centered on RNAP II\u2013mediated transcription regulation best captures the core function.","confidence":"Medium","size":11,"edges":13,"triangles":0,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0070895","count":3},{"id":"GO:0046022","count":3},{"id":"GO:0007576","count":3},{"id":"GO:0010729","count":3}]},{"hash":"1691309053532623551","title":"Cardiac and Neural Morphogenesis","description":"This cluster is dominated by developmental processes related to heart and brain morphogenesis. Top terms include heart looping, neural tube closure, forebrain morphogenesis, and coronary vasculature development, indicating cardiac and neural tissue formation. Additional terms for MAP kinase signaling regulation and dopamine uptake regulation point to developmental signaling and neural activity, while DNA repair/transcription terms are present but less central. Overall, the proteins most plausibly function together in cardiac and neural development.","confidence":"High","size":11,"edges":4,"triangles":0,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0001947","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0048853","count":4},{"id":"GO:0043407","count":4}]},{"hash":"1317019010440097571","title":"Neuronal Pain and Temperature Signaling","description":"This cluster is dominated by GO terms for sensory perception of pain, cellular response to temperature stimulus, thermogenesis, calcium release, and membrane potential regulation, which together point to neuronal signaling and thermosensory/pain pathways. The other terms (blood coagulation, xenobiotic response, electron transport) are less central and may reflect broader cellular contexts or pleiotropy.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0051209","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0002024","count":3},{"id":"GO:0071502","count":3}]},{"hash":"1629202509802022031","title":"Neural development and synapse formation","description":"The cluster is dominated by GO terms related to nervous system development and synaptic establishment: in utero embryonic development, neural tube closure, motor neuron axon guidance, postsynaptic membrane assembly, acetylcholine receptor signaling, receptor clustering, and Wnt signaling. These together point to neural development and the assembly of synaptic connections, including guidance cues and synaptic signaling. The presence of regulatory terms like negative regulation of transcription is secondary and not defining the cluster.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0001701","count":3},{"id":"GO:0043277","count":2},{"id":"GO:0001843","count":2}]},{"hash":"2062176256477579913","title":"Nuclear import and mitotic/meiotic chromosome segregation","description":"The GO terms are dominated by nuclear transport functions (nuclear pore complex assembly, import into nucleus, NLS-bearing protein import) and chromosome handling during cell division (meiotic/mitotic spindle dynamics, sister chromatid cohesion and separation, nuclear membrane reassembly). The combination suggests a cluster centered on nuclear import processes connected to chromosome segregation during mitosis and meiosis, with desumoylation regulation as a supporting nuclear process.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060188","count":5},{"id":"GO:0051292","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0006610","count":5},{"id":"GO:0006607","count":5}]},{"hash":"1031209854256916269","title":"Organ and tissue development signaling","description":"The cluster is dominated by placenta, thymus, and mammary gland development terms, indicating a developmental theme across tissues. Supporting terms include regulation of MAPK/JNK signaling and caveolin-mediated endocytosis, pointing to signaling and trafficking activities involved in development. Some terms touch on cell-cycle and metabolism contexts that can accompany proliferation, but the overall theme centers on organ/tissue development with associated signaling. ","confidence":"Medium","size":11,"edges":25,"triangles":23,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001890","count":11},{"id":"GO:0048538","count":11},{"id":"GO:0071276","count":11},{"id":"GO:0000187","count":11},{"id":"GO:0072584","count":10}]},{"hash":"429058543932394278","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0000447","count":4},{"id":"GO:0001731","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0000472","count":3}]},{"hash":"1266758536366112661","title":"Signaling Regulation and Neural Development","description":"The cluster is enriched for terms about regulation of signaling pathways, including negative regulation of ERK cascade, T cell receptor signaling, and cyclin-dependent kinase activity, plus peptidyl-tyrosine dephosphorylation, indicating a focus on phosphorylation-based signaling control. Insulin receptor signaling appears among the terms, broadening to metabolic signaling. The presence of cerebellar cortex formation and Bergmann glial cell differentiation suggests a neural development angle as well. Overall, these proteins seem to function as regulators of signaling with a neural development connection, hence the combined label.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0000200","count":9},{"id":"GO:0070373","count":9},{"id":"GO:0050860","count":9},{"id":"GO:0034501","count":8},{"id":"GO:0045736","count":8}]},{"hash":"1775260060938557525","title":"Multi-lineage embryonic differentiation","description":"This cluster is enriched for GO terms across various tissue lineages (muscle, pancreas, inner ear, oligodendrocytes, osteoclasts, neural crest\u2013related morphogenesis) and broader developmental processes (sex determination, thyroid hormone response). The shared theme is diverse differentiation events during embryogenesis rather than a single pathway, which supports a broad developmental differentiation label.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035914","count":9},{"id":"GO:0031018","count":9},{"id":"GO:0042491","count":8},{"id":"GO:0007540","count":8},{"id":"GO:0072277","count":8}]},{"hash":"46387479869928611","title":"Neuronal morphogenesis and synaptic trafficking","description":"The top GO terms cluster around neural development and connectivity, including auditory receptor morphogenesis, nerve branching, filopodium dynamics, cytoskeletal/tubulin assembly, and vesicle transport for neurotransmitter secretion, indicating neurite outgrowth and synaptic maturation; a single outlier term on interferon production does not override the neural-focused theme.","confidence":"High","size":11,"edges":34,"triangles":51,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048873","count":11},{"id":"GO:0032729","count":11},{"id":"GO:0002093","count":10},{"id":"GO:0031578","count":10},{"id":"GO:0007021","count":10}]},{"hash":"499067581698205556","title":"Developmental signaling and cytoskeletal remodeling","description":"This cluster centers on developmental processes (labyrinthine layer morphogenesis, fusion cell fate specification) and signaling responses (TGF-beta, nerve growth factor), coupled with cytoskeletal rearrangements (actin crosslink formation) and immune-related activity (innate immune response, engulfment of apoptotic cell). Together these terms suggest signaling-driven cytoskeletal changes during development and immune remodeling. The link is plausible but not perfect due to some metabolism-related terms, so the label is credible but not definitive.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060670","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0035156","count":3},{"id":"GO:0014911","count":3},{"id":"GO:0061847","count":3}]},{"hash":"1766139096052567723","title":"Vacuolar amino acid transport","description":"The cluster is dominated by GO terms for transporting various amino acids (proline, arginine, histidine, lysine, glutamate, glutamine) across the vacuolar membrane, with additional links to cellular responses to nitrogen starvation. This suggests a cohesive set of vacuolar amino acid transporters involved in nutrient storage and mobilization under nutrient stress.","confidence":"High","size":11,"edges":9,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0015824","count":3},{"id":"GO:1990818","count":2},{"id":"GO:1901482","count":2},{"id":"GO:0006867","count":2},{"id":"GO:0090513","count":2}]},{"hash":"2003773300539575440","title":"Embryonic organ morphogenesis","description":"This cluster shows a strong enrichment for developmental and morphogenetic terms across multiple organs, including cardiac muscle development/heart morphogenesis, pituitary gland development, nucleus accumbens development, and embryonic digestive tract development, plus proximal/distal pattern formation. While a few terms refer to metabolic processes, the dominant theme is embryonic organ morphogenesis across diverse tissues.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0048738","count":11},{"id":"GO:0009954","count":11},{"id":"GO:0006069","count":11},{"id":"GO:0021983","count":11},{"id":"GO:0003007","count":11}]},{"hash":"2191658802754376070","title":"Spliceosome-Regulated Splicing and Circadian Rhythm","description":"This cluster is driven by two GO terms for spliceosome-mediated splicing regulation (positive regulation of mRNA splicing via spliceosome; regulation of alternative mRNA splicing, via spliceosome), pointing to a core function in RNA processing. Additional terms for circadian rhythm and stress-related processes (apoptosis, ubiquitination) suggest broader coordination of splicing with timing and cellular stress responses. The strongest link is splicing regulation, with circadian association as a secondary theme.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:1903265","count":2},{"id":"GO:0070936","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0006378","count":2}]},{"hash":"1594078401184382981","title":"Inflammation and redox signaling","description":"The top GO terms cluster around inflammatory response, redox homeostasis and detoxification (including mercury detoxification and cellular oxidant detoxification), with supporting signals in phosphorylation regulation and proteolysis. This pattern suggests a cellular stress response linking immune signaling to redox balance and detoxification rather than a single, focused metabolic function.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0033138","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0043488","count":3},{"id":"GO:0006508","count":2},{"id":"GO:0050787","count":2}]},{"hash":"1773196564171509688","title":"ER stress and vascular growth signaling","description":"This cluster centers on the unfolded protein response and on positive regulation of endothelial proliferation, fibroblast migration, and PI3K/AKT\u2013mediated growth, suggesting ER stress\u2013driven vascular remodeling. While a couple of terms relate to neural or kidney development, the dominant theme ties stress response to angiogenic and migratory signaling.","confidence":"Medium","size":11,"edges":31,"triangles":39,"max_degree":10,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0006986","count":7},{"id":"GO:0043154","count":6},{"id":"GO:0050731","count":6},{"id":"GO:2001027","count":6},{"id":"GO:0051897","count":6}]},{"hash":"84300185881089433","title":"Mitochondrial respiration and redox balance","description":"The top GO terms cluster around mitochondrial electron transport, cellular redox homeostasis, glycolysis, and glutathione metabolism, indicating a central metabolism/redox-focused group. Additional terms like beta-alanine biosynthesis and detox/catabolic processes (camphor, herbicide) suggest broader metabolic capabilities. A few terms (granulocyte differentiation, pituitary gland development) seem less connected and may reflect annotation noise or multifunctional proteins.","confidence":"Medium","size":11,"edges":16,"triangles":6,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0006120","count":4},{"id":"GO:0045454","count":4},{"id":"GO:0019483","count":3},{"id":"GO:0006096","count":3}]},{"hash":"1272123846754603135","title":"Actin cytoskeleton remodeling and membrane protrusions","description":"The top GO terms cluster around actin dynamics\u2014dendritic spine morphogenesis, lamellipodium/ruffle assembly, actin filament polymerization, and barbed-end capping\u2014pointing to coordinated actin remodeling that drives spine formation, membrane protrusions, and cell motility. Some terms (bone development, Ras signaling regulation) may reflect broader roles of cytoskeletal signaling in development, but the dominant theme is actin-driven remodeling.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":2},{"id":"GO:1900029","count":2},{"id":"GO:0030032","count":2},{"id":"GO:0051497","count":2},{"id":"GO:0051016","count":2}]},{"hash":"785684997726415","title":"Unknown","description":"The GO terms are highly heterogeneous: sodium ion transport, DNA-templated transcription, skin and cartilage development, receptor signaling regulation, and various sensory perception terms (pain and sour taste) alongside a few metabolic processes. There is no clear, single biological function unifying these proteins, suggesting the cluster represents diverse roles rather than a cohesive pathway.","confidence":"","size":11,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0010754","count":2}]},{"hash":"395782620502792362","title":"Vascular development and coagulation","description":"The top GO terms are dominated by blood coagulation, positive regulation of endothelial cell proliferation, and lymphangiogenesis, with supporting terms for organ development and complement activation. This pattern suggests a cluster of proteins involved in vascular remodeling and coagulation, with related developmental and immune-context functions. Confidence: High","confidence":"","size":11,"edges":30,"triangles":38,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":4},{"id":"GO:0030324","count":3},{"id":"GO:0030325","count":3},{"id":"GO:0001938","count":3},{"id":"GO:0010996","count":2}]},{"hash":"349696565255254268","title":"Unknown","description":"The GO terms are diverse: pain perception, temperature stimulus, saliva secretion, immune degranulation, and tissue development across retina and lung. There is no single shared function or pathway linking all proteins, indicating a heterogeneous set rather than a cohesive cluster. ","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0071502","count":7},{"id":"GO:0042391","count":5},{"id":"GO:0046541","count":5}]},{"hash":"1205937087383799201","title":"Innate Immune Response and Unfolded Protein Response","description":"Based on the top GO terms, the cluster is enriched for defense response to virus and innate immune response, plus response to unfolded protein, suggesting involvement in antiviral signaling and ER stress pathways. Other terms like regulation of gluconeogenesis, cell division, APC-dependent catabolic process, and prostate gland development appear sporadic or noisy, implying annotation noise or multi-function proteins rather than a single unified function. With no observed edges, the set likely groups proteins with immune/ER stress roles rather than a distinct pathway.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051607","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0090526","count":4},{"id":"GO:0051301","count":4},{"id":"GO:1902391","count":4}]},{"hash":"760410836196176733","title":"Stem cell differentiation and transcriptional regulation","description":"The terms point to core transcription and chromatin control (DNA-templated transcription initiation, RNA Pol II preinitiation complex assembly, protein localization to chromatin) together with stem-cell\u2013related differentiation programs (granulocyte and intestinal epithelial cell differentiation) and Notch signaling modulation, plus proliferation. This suggests a cohesive theme of transcriptional/chromatin regulation governing stem cell fate and lineage specification, with metabolic regulation as a supporting context.","confidence":"High","size":11,"edges":17,"triangles":7,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":2},{"id":"GO:2000648","count":2},{"id":"GO:0045820","count":2},{"id":"GO:0030851","count":2},{"id":"GO:0045892","count":2}]},{"hash":"1146913737742654032","title":"Embryonic morphogenesis and patterning","description":"The top GO terms indicate involvement in developmental morphogenesis (cartilage, hair follicle, palate) and left/right pattern formation, suggesting a role in embryonic tissue patterning. While transcription regulation terms appear, the dominant signal is developmental morphogenesis, so this name captures the cluster\u2019s core function.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":11},{"id":"GO:0060972","count":11},{"id":"GO:1903026","count":11},{"id":"GO:0006351","count":11},{"id":"GO:0000055","count":11}]},{"hash":"271347353982937472","title":"Chromatin remodeling and transcription regulation","description":"Most terms cluster around chromatin dynamics and gene expression control, e.g., nucleosome disassembly, RNA methylation, histone methylation, and transcription regulation from RNA polymerase II promoters. A few terms pertain to development or cytoskeletal regulation, but the strongest, most frequent signals point to chromatin remodeling and transcriptional regulation as the shared theme. Confidence reflects that core link, tempered by the presence of divergent developmental terms. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001843","count":2},{"id":"GO:0061038","count":2},{"id":"GO:0001662","count":2},{"id":"GO:0035948","count":2},{"id":"GO:0006337","count":2}]},{"hash":"1906145630532470144","title":"Ciliary axoneme assembly and tubulin modifications","description":"The proteins are enriched for cilium/flagellum-related terms (sperm axoneme assembly, flagellated sperm motility, cilium movement, regulation of axon extension) and tubulin post-translational modifications (polyglutamylation, polyglycylation) with associated microtubule severing, suggesting a coherent role in ciliary/axoneme structure and its microtubule regulation, while xenobiotic catabolic and transcription terms appear ancillary.","confidence":"High","size":10,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0042738","count":3},{"id":"GO:1905419","count":3},{"id":"GO:0030516","count":3},{"id":"GO:0018094","count":3},{"id":"GO:0003351","count":3}]},{"hash":"1817584571872916637","title":"Ubiquitin-regulated trafficking and stress response","description":"This cluster centers on protein deubiquitination and regulation of vesicle trafficking (endocytosis, intralumenal vesicle formation, ERAD-related processes) and ties in with cellular stress responses (cadmium/insecticide exposure) and signaling pathways (Toll-like and calcium signaling), suggesting a theme of ubiquitin-dependent control of protein homeostasis and trafficking under stress.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":8},{"id":"GO:1905366","count":4},{"id":"GO:0071276","count":4},{"id":"GO:0030578","count":4},{"id":"GO:1904378","count":4}]},{"hash":"2239870659063339394","title":"Embryonic organ morphogenesis","description":"The top GO terms cluster around morphogenesis and development across multiple organs, including adipose tissue differentiation, retina morphogenesis, forebrain development, ureteric bud branching, semicircular canal fusion, and diencephalon development. This points to a coherent theme of embryonic organogenesis and tissue morphogenesis, with accompanying signaling events such as Akt activation and calcium channel regulation that commonly participate in developmental processes.","confidence":"High","size":10,"edges":34,"triangles":51,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0050872","count":7},{"id":"GO:0060059","count":7},{"id":"GO:0021846","count":7},{"id":"GO:0048807","count":7},{"id":"GO:0060879","count":5}]},{"hash":"392555316483396346","title":"Unknown","description":"The GO terms are scattered across diverse biological processes, with only a small subset related to vascular development (negative regulation of vasculogenesis, VEGF signaling, endothelial differentiation) and the rest spanning metabolism and transport. There is no clear, cohesive theme tying all terms together, so a definite cluster function cannot be inferred.","confidence":"","size":10,"edges":42,"triangles":98,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0007595","count":2},{"id":"GO:2001213","count":2},{"id":"GO:0006814","count":2},{"id":"GO:0009399","count":2}]},{"hash":"1114403890289114659","title":"Cell cycle and proteostasis with RNA processing","description":"This cluster centers on regulated protein turnover (proteasome/ubiquitin, endopeptidase activity) and cell cycle progression with mitotic exit, while also including RNA processing and ribosome biogenesis, mitochondrial fission, and signaling pathways (Wnt and TNF), implying a coordinated program governing growth, division, and gene expression.","confidence":"Medium","size":10,"edges":20,"triangles":15,"max_degree":8,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0010950","count":4},{"id":"GO:0043161","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0000398","count":3},{"id":"GO:0000266","count":3}]},{"hash":"2126889102096967802","title":"Neuronal Synaptic Plasticity and Transmission","description":"This cluster centers on neural communication and plasticity, with frequent GO terms for short- and long-term synaptic regulation, excitatory postsynaptic potentials, glutamatergic transmission, and receptor clustering, alongside GABA signaling and sensory-related processes like visual learning and phototaxis. The unified theme is proteins involved in synaptic signaling and plasticity within sensory neural circuits.","confidence":"High","size":10,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048169","count":5},{"id":"GO:0048172","count":5},{"id":"GO:0060079","count":5},{"id":"GO:0008542","count":5},{"id":"GO:0097011","count":5}]},{"hash":"85454955378563620","title":"Dopaminergic Synaptic Signaling and Visual Perception","description":"The top GO terms cluster around dopaminergic synaptic transmission, visual perception/learning, and signaling pathways (ERK cascade, prostaglandin response), suggesting a brain-related signaling and sensory-processing module. Some terms appear as outliers (heart development, macrophage chemotaxis), but the dominant theme is neural communication and sensory processing.","confidence":"Medium","size":10,"edges":24,"triangles":16,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0048148","count":6},{"id":"GO:0010759","count":6},{"id":"GO:0019233","count":6}]},{"hash":"2021241112486274750","title":"mRNA Splicing and Export Machinery","description":"The top GO terms cluster around mRNA splicing via the spliceosome, splice-site recognition, mRNA export from the nucleus, and mRNA stability/regulation, with some translation initiation context, indicating a module of RNA processing and mRNA regulation rather than a single enzymatic activity.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":4},{"id":"GO:0006378","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0048026","count":3}]},{"hash":"376981879778062818","title":"Ubiquitin-Dependent Turnover and Autophagy","description":"The cluster is dominated by GO terms related to ubiquitin-mediated protein degradation (ubiquitin-dependent catabolic processes, autoubiquitination, K29-linked ubiquitination) and autophagy (engulfment by autophagosome). While there are additional terms touching on GTPase regulation and other processes, the strongest common theme is ubiquitin-dependent proteostasis and autophagic turnover, indicating proteins involved in targeted degradation and recycling pathways.","confidence":"High","size":10,"edges":30,"triangles":37,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":10},{"id":"GO:0042787","count":9},{"id":"GO:0019089","count":8},{"id":"GO:0010794","count":8},{"id":"GO:0051865","count":8}]},{"hash":"1682661085545685838","title":"Ubiquitin-dependent innate immune signaling","description":"The cluster shows strong enrichment for ubiquitin-related processes (ubiquitin-dependent protein catabolic process; protein polyubiquitination) alongside innate immune functions (innate immune response; defense response to virus) and phagolysosome assembly, plus signaling roles (regulation of JNK cascade; activation of GTPase activity). This combination suggests proteins act together in ubiquitin-mediated regulation of innate immune signaling and related stress responses.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0045087","count":4},{"id":"GO:0046328","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0000209","count":3}]},{"hash":"747780120993259872","title":"NF-\u03baB signaling and innate immune activation","description":"The cluster is dominated by GO terms related to NF-\u03baB pathway activation (canonical and non-canonical), TNF-mediated signaling, and innate immune responses, with supportive terms about translation initiation regulation and proteasome-related processes that couple to NF-\u03baB activation. This suggests a coherent theme of immune signaling and era-specific transcriptional regulation mediated by NF-\u03baB.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043248","count":2},{"id":"GO:0000338","count":2},{"id":"GO:0006446","count":2},{"id":"GO:0007250","count":2},{"id":"GO:0001731","count":2}]},{"hash":"1655869391744367892","title":"RNA processing and translation initiation","description":"The top GO terms show strong signals for RNA maturation and processing (splicing via spliceosome, splice site recognition, mRNA export, stabilization) along with initiation of translation (translation reinitiation, formation of translation preinitiation complex). This suggests a cluster of proteins coordinating RNA processing with the onset of protein synthesis rather than a single pathway.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0048026","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0010610","count":2}]},{"hash":"1835311577582121160","title":"Golgi-endosome trafficking and recycling","description":"Most enriched terms point to vesicular transport within the secretory pathway: endocytic recycling, retrograde transport from endosome to Golgi, intracellular protein transport, and protein retention in the Golgi, plus vacuole-ER tethering. These collectively indicate a cohesive cluster of proteins involved in sorting and trafficking between endosomes, Golgi, and ER, with a few RNA-processing and ECM-related terms likely reflecting incidental connections or annotation noise.","confidence":"High","size":10,"edges":19,"triangles":11,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1990126","count":4},{"id":"GO:0048025","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0000448","count":2},{"id":"GO:0045053","count":2}]},{"hash":"2002127777228438729","title":"Membrane transport and ion homeostasis","description":"GO terms are dominated by several transmembrane transport processes (fructose, chloride, L-aspartate, oxalate) and by regulation of membrane potential and intracellular pH, which together point to membrane transport and ion homeostasis as the cluster's core function. There are also sporulation and transcription regulation terms, but they are sparse and may reflect broader annotations rather than a single motif. The absence of network edges does not change the transport-centered interpretation.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061038","count":2},{"id":"GO:0007605","count":1},{"id":"GO:0015755","count":1},{"id":"GO:1902476","count":1},{"id":"GO:0042391","count":1}]},{"hash":"720797379296388023","title":"Retina GPCR Signaling and Phototransduction","description":"This cluster is strongly enriched for GPCR-related signaling terms, including dopamine- and adrenergic-receptor pathways, along with downstream cAMP and phospholipase C activation. The presence of retina development and phototransduction terms points to a visual-system focus, suggesting these proteins participate in GPCR-driven signaling in the retina. Some terms also touch on broader developmental processes such as heart development and cell proliferation, which may reflect shared signaling modules. Overall, the dominant theme is GPCR-mediated signaling linked to retinal function, supporting this label.","confidence":"Medium","size":10,"edges":12,"triangles":3,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":9},{"id":"GO:0008283","count":9},{"id":"GO:0060041","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0071880","count":8}]},{"hash":"1965208322041247385","title":"Neural development and vesicle exocytosis","description":"Many top GO terms center on neural-related development (nervous system, brain) and broader developmental processes (heart, skeletal system), combined with vesicle fusion and calcium-dependent exocytosis and regulated exocytosis. This points to proteins involved in developmental signaling that relies on secretory pathways, especially in neural contexts. Some terms appear plant/yeast-specific or outliers, but the core theme is development with vesicle-mediated signaling.","confidence":"Medium","size":10,"edges":43,"triangles":105,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":10},{"id":"GO:0001302","count":10},{"id":"GO:0007399","count":10},{"id":"GO:0006906","count":10},{"id":"GO:0043547","count":10}]},{"hash":"419922517301496263","title":"Unknown","description":"Top terms cover endocytosis, various proliferation and development processes, cell-cycle activity, signaling regulation, metabolism, and immune responses. There is no single coherent function or pathway that ties all these terms together, so a precise, representative label cannot be assigned.","confidence":"","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0072584","count":10},{"id":"GO:0033598","count":10},{"id":"GO:1990804","count":10},{"id":"GO:0007098","count":10},{"id":"GO:0043506","count":10}]},{"hash":"1440528296767807387","title":"Caveolin-mediated endocytosis and sphingolipid signaling","description":"The strongest shared function among the top GO terms is caveolin-mediated endocytosis and regulation of sphingolipid biosynthesis, pointing to a caveolae/lipid-raft\u2013associated endocytic signaling module. Other terms appear more peripheral to this core theme (centrosome cycle, JNK regulation, neuron development, cardiac proliferation, cytosine metabolism, IL-7 response), and one term is obsolete.","confidence":"Medium","size":10,"edges":40,"triangles":86,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0072584","count":10},{"id":"GO:0033598","count":10},{"id":"GO:1990804","count":10},{"id":"GO:0007098","count":10},{"id":"GO:0043506","count":10}]},{"hash":"595568377995077230","title":"Ribosome biogenesis and rRNA processing","description":"This cluster is dominated by GO terms for ribosomal large subunit biogenesis, rRNA processing, and maturation of SSU rRNA, pointing to a shared role in ribosome assembly in the nucleolus. While a few histone modification and developmental terms appear, they seem ancillary. So the core theme is ribosome production and rRNA maturation.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016574","count":1},{"id":"GO:2001229","count":1},{"id":"GO:0048316","count":1},{"id":"GO:0016571","count":1},{"id":"GO:0010048","count":1}]},{"hash":"429849689808531019","title":"Golgi-ER-Endosome Vesicle Trafficking","description":"This cluster is dominated by GO terms for vesicle transport among the endoplasmic reticulum, Golgi, endosomes, and related trafficking steps (ER-to-Golgi, Golgi-to-endosome, retrograde Golgi-ER), plus endocytosis and small GTPase signaling, pointing to a cohesive vesicle trafficking module. Some terms about nervous system and spermatid development may reflect tissue-specific roles of trafficking proteins.","confidence":"High","size":10,"edges":14,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":7},{"id":"GO:0006897","count":5},{"id":"GO:0007286","count":5},{"id":"GO:0007264","count":5},{"id":"GO:0006895","count":5}]},{"hash":"704023149439599347","title":"Neuronal synaptic signaling and calcium-dependent plasticity","description":"The top GO terms cluster around neurotransmitter secretion, regulation of synaptic vesicle exocytosis, long-term potentiation, memory, and calcium ion signaling, indicating proteins involved in calcium-driven synaptic transmission and synaptic plasticity in neurons. While some terms relate to stress or apoptosis, the dominant signal is neuronal synaptic activity and calcium-dependent plasticity.","confidence":"High","size":10,"edges":7,"triangles":2,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043065","count":8},{"id":"GO:0007269","count":8},{"id":"GO:0071456","count":7},{"id":"GO:0070588","count":7},{"id":"GO:0007613","count":7}]},{"hash":"957611674855914223","title":"Developmental signaling and cell adhesion","description":"This cluster aggregates proteins tied to developmental processes (heart development, angiogenesis, neuron migration) and cell-adhesion/signaling (calcium-independent adhesion, substrate spreading, MAPK regulation), indicating a cohesive theme of developmental signaling intersecting with cell-matrix interactions.","confidence":"Medium","size":10,"edges":36,"triangles":63,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:2001108","count":7},{"id":"GO:0007161","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0021836","count":7},{"id":"GO:0045163","count":7}]},{"hash":"1319515416691546240","title":"Brain and nervous system development","description":"These proteins are enriched for neural and brain development terms (nervous system development, brain development, inner ear development, globus pallidus development) and related locomotory behavior. A few terms touch on neural signaling and excitable tissue function (sodium ion transport, ventricular action potential), but the dominant theme is brain and nervous system development. The lack of network edges suggests these annotations reflect functional potential rather than observed interactions.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0048839","count":2},{"id":"GO:1903263","count":2},{"id":"GO:0007626","count":2}]},{"hash":"1693081036886509718","title":"Olfactory nerve development and glycosphingolipid biosynthesis","description":"The terms cluster around glycosylation and glycosphingolipid metabolism (N-linked glycosylation, N-glycan processing, protein sialylation, glycosylceramide/ganglioside biosynthesis, oligosaccharide metabolism) together with olfactory development processes (olfactory nerve formation, olfactory placode morphogenesis). This suggests proteins that modify surface glycans and lipids critical for olfactory neuron development, linking glycosylation pathways to olfactory system formation.","confidence":"High","size":10,"edges":10,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0018279","count":2},{"id":"GO:0006491","count":2},{"id":"GO:0006054","count":2},{"id":"GO:0009860","count":2},{"id":"GO:0001574","count":2}]},{"hash":"496746458805893599","title":"Neural development and glial dynamics","description":"This cluster centers on neural and glial-associated processes: Schwann cell migration/proliferation regulation, neurofilament cytoskeleton organization, and glutamate reuptake, pointing to nervous system development and maintenance. Additional signals like ceramide and collagen biosynthesis suggest supporting roles from lipid metabolism and extracellular matrix in neural contexts, indicating a broader theme of nerve maintenance and glial-neuron interactions.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1900148","count":2},{"id":"GO:0044257","count":2},{"id":"GO:0050881","count":2},{"id":"GO:1905045","count":2},{"id":"GO:0046513","count":2}]},{"hash":"2001235021932868803","title":"Craniofacial and ectodermal morphogenesis","description":"The terms cluster around embryonic development of craniofacial and ectodermal structures (palate, cartilage, left-right patterning, hair follicles) with broader transcriptional regulation, suggesting a cohesive theme of craniofacial/ectodermal morphogenesis.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0060021","count":10},{"id":"GO:0060536","count":9},{"id":"GO:0060972","count":9},{"id":"GO:0006351","count":9}]},{"hash":"1912740274945749599","title":"Immune cell adhesion and phagocytosis regulation","description":"The top GO terms cluster around cell-cell adhesion (heterophilic and homophilic) and immune regulation (complement activation, NK/T cell regulation, macrophage activation, phagocytosis and its recognition/engulfment). A few terms hint at tissue development (heart development), but the dominant signal is immune cell interactions and clearance processes, suggesting proteins involved in cell adhesion linked to immune responses and phagocytosis. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":6},{"id":"GO:0006958","count":5},{"id":"GO:0007156","count":5},{"id":"GO:0002859","count":4},{"id":"GO:0007507","count":4}]},{"hash":"363899345329586791","title":"Developmental lipid metabolism and signaling","description":"This cluster is enriched for developmental processes (brain development, myoblast fusion) and lipid-related metabolic regulation (phospholipid catabolic process, sphingolipid biosynthesis regulation, dolichyl phosphate biosynthesis regulation), with additional signaling and vesicle trafficking terms (VEGF signaling, B cell receptor signaling, protein localization to phagocytic vesicle). The combination suggests a theme around membrane biology guiding developmental signaling, though the set also includes broader regulatory processes, hence a cautious but specific label. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007420","count":7},{"id":"GO:0009395","count":5},{"id":"GO:0090153","count":5},{"id":"GO:0010794","count":5},{"id":"GO:0007520","count":5}]},{"hash":"404465611623931375","title":"RNA Pol II Transcription Regulation and Nucleotide Salvage","description":"These proteins cluster around RNA polymerase II\u2013related transcription terms, including DNA-templated transcription and negative regulation of transcription by RNA Pol II, suggesting a core role in modulating Pol II\u2013driven transcription. The simultaneous appearance of nucleotide-salvage terms (UMP, uracil, CTP salvage) indicates a secondary link to nucleotide metabolism, which can be connected to transcription-associated chromatin and replication processes. The presence of obsolete terms lowers precision slightly, but the dominant signal supports a transcription-regulation-centered cluster with a nucleotide-salvage facet.","confidence":"Medium","size":10,"edges":11,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0070895","count":3},{"id":"GO:0046022","count":3},{"id":"GO:0007576","count":3},{"id":"GO:0010729","count":3}]},{"hash":"21875573148488232","title":"Innate Immune Activation and Leukocyte Recruitment","description":"This cluster centers on innate immune activity and inflammatory signaling, evidenced by terms like positive regulation of eosinophil degranulation, positive regulation of neutrophil killing of gram-negative bacteria, dendritic cell chemotaxis, and response to lipopolysaccharide. There are also developmental terms (lung, heart, retina) and endothelial barrier regulation that may reflect pleiotropic roles or broader tissue-context functions. Still, the dominant pattern is innate immune response and leukocyte recruitment.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":10},{"id":"GO:0060427","count":10},{"id":"GO:0070963","count":10},{"id":"GO:0051482","count":10},{"id":"GO:0060041","count":10}]},{"hash":"2216460822400481853","title":"Steroid metabolism and xenobiotic catabolism","description":"The top GO terms cluster around steroid-related pathways (testosterone biosynthesis, cholesterol and vitamin D catabolism, brassinosteroid biosynthesis) and xenobiotic/camphor catabolic processes, indicating a shared function in processing diverse organic molecules. The additional terms about hepatocyte and gonadal development hint at tissue contexts where such metabolism is critical, but the dominant theme is metabolic processing of steroids and xenobiotics.","confidence":"Medium","size":10,"edges":11,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1900087","count":5},{"id":"GO:0008585","count":5},{"id":"GO:0019383","count":5},{"id":"GO:0061370","count":5},{"id":"GO:0006707","count":5}]},{"hash":"657299345775833169","title":"Anti-angiogenic regulation of vascular development","description":"Top GO terms emphasize negative regulation of endothelial proliferation, blood vessel maturation, and organ formation (lung and kidney development). This suggests the proteins act as anti-angiogenic regulators impacting vascularization and organ morphogenesis, with additional signaling modulation terms that broadly constrain growth. Overall, the cluster coherently points to suppression of vascular growth and related organ development.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0090281","count":6},{"id":"GO:0050732","count":6},{"id":"GO:0001937","count":6},{"id":"GO:0002176","count":6},{"id":"GO:0010751","count":6}]},{"hash":"833615839755314377","title":"Hair Keratinization and Hair Cycle","description":"The top GO terms are hair cycle and keratinization, both central to hair follicle biology and the formation of the keratinized hair shaft. This suggests the proteins cluster around hair follicle differentiation and keratinized tissue development, making this label representative.","confidence":"High","size":10,"edges":39,"triangles":80,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042633","count":10},{"id":"GO:0031424","count":10}]},{"hash":"283981743076899512","title":"Developmental gene regulation and differentiation","description":"The terms point to developmental processes across tissues (embryonic development, stem cell differentiation, neuron differentiation, germ-line development) and gene expression control (transcriptional regulation, mRNA surveillance, translation initiation assembly, deneddylation). This suggests a theme of developmental regulation of gene expression, though no single specific function dominates, hence a Moderate confidence.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071033","count":1},{"id":"GO:0007127","count":1},{"id":"GO:0070196","count":1},{"id":"GO:0000973","count":1},{"id":"GO:0001701","count":1}]},{"hash":"121542188552982748","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0032543","count":3},{"id":"GO:0042273","count":2},{"id":"GO:0000465","count":1},{"id":"GO:0000463","count":1}]},{"hash":"525592028039643617","title":"Meiosis-associated recombination and DNA damage response","description":"The top GO terms show responses to DNA-damaging agents (camptothecin, cisplatin, hydroxyurea) and DNA repair via homologous recombination, plus telomere maintenance through recombination and several meiosis-specific processes (meiotic joint molecule formation, sister chromatid cohesion in meiosis, mating-type switching). This points to a cluster of proteins involved in coordinating DNA damage repair with meiosis and recombination pathways.","confidence":"High","size":9,"edges":33,"triangles":64,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0072757","count":6},{"id":"GO:0000732","count":6},{"id":"GO:0010569","count":6},{"id":"GO:0000709","count":6},{"id":"GO:1904631","count":6}]},{"hash":"452584522346693028","title":"Translational Regulation and mRNA Metabolism","description":"The top GO terms are dominated by translation-related processes (translation, translational initiation, and regulation of elongation/termination) and mRNA turnover/processing (deadenylation-dependent decay; RNA-templated transcription). This points to a cluster centered on control of protein synthesis and RNA fate, with a few outliers (viral genome replication, glial proliferation, antibiotic response) that may reflect annotation noise or broader functional links.","confidence":"Medium","size":9,"edges":15,"triangles":13,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0019079","count":4},{"id":"GO:0006413","count":4},{"id":"GO:0045901","count":3},{"id":"GO:1902802","count":3}]},{"hash":"2166365937113823617","title":"Cardiovascular and hematopoietic function cluster","description":"The top GO terms cluster around cardiovascular and blood biology: regulation of blood pressure, nitric oxide transport, platelet aggregation, erythrocyte maturation, heart development, and response to hypoxia, suggesting a shared theme of vascular and blood cell function. Some terms (CNS myelin maintenance, sebaceous gland differentiation) are outliers, which lowers the overall cohesion but do not overturn the primary cardiovascular/hematopoietic signal. Confidence: Medium","confidence":"","size":9,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032286","count":3},{"id":"GO:0006675","count":3},{"id":"GO:0001949","count":3},{"id":"GO:0001666","count":2},{"id":"GO:0043249","count":2}]},{"hash":"418912750391652979","title":"Mitochondrial function and ECM remodeling","description":"The top GO terms cluster around mitochondrial processes (mitochondrial respiratory chain complex IV assembly, inheritance, and stress-induced fusion), indicating a mitochondrial function theme. The concurrent extracellular matrix organization and disassembly terms, along with podocyte development, suggest ECM remodeling relevant to kidney tissue. Lipid signaling terms (SREBP pathway, cholesterol biosynthesis regulation) add a metabolic signaling context that can intersect mitochondrial function and ECM dynamics. Overall, the cluster appears centered on mitochondrial function with supporting ECM remodeling and signaling aspects.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":2},{"id":"GO:0030198","count":2},{"id":"GO:0022617","count":1},{"id":"GO:0032933","count":1},{"id":"GO:0070528","count":1}]},{"hash":"1907354874950174454","title":"Embryonic morphogenesis and organ development","description":"The GO terms are dominated by embryonic development and organogenesis: cartilage morphogenesis, left/right pattern formation, placenta-related and endocrine system development, pancreatic cell development, and EMT in heart development. Together these terms point to broad embryonic tissue morphogenesis rather than a defined single pathway, with a few outliers (telomere maintenance regulation) that are less central. ","confidence":"Medium","size":9,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003323","count":2}]},{"hash":"648446008343913552","title":"Wnt-TGF-\u03b2 Signaling and EMT Regulators","description":"Because GO terms cluster around Wnt signaling modulation, TGF-\u03b2\u2013mediated responses, and epithelial-to-mesenchymal transition (with supporting integrin signaling and heparan sulfate proteoglycan roles), the proteins likely participate in coordinating signaling for cell adhesion, proliferation, and EMT. Some terms (lipid catabolism, telomeric looping) seem incidental to this core theme.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009395","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0090090","count":2}]},{"hash":"2291569901493322789","title":"Immune Signaling with Actin Remodeling","description":"The cluster centers on innate and adaptive immune responses (innate/adaptive defense, defense against virus) and related signaling pathways (regulation of JNK, NF-kappaB). Actin crosslink formation suggests cytoskeletal remodeling accompanying immune activation and synapse formation; a couple terms (heart development, long-term synaptic potentiation) appear as less central annotations. ","confidence":"High","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0002250","count":3},{"id":"GO:0046007","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0051607","count":2}]},{"hash":"189329033743601402","title":"Cytoskeletal dynamics and vesicle trafficking","description":"The cluster centers on actin- and cytoskeleton-related processes: skeletal muscle thin filament assembly and fiber development point to actin organization; regulation of endocytosis, vacuole inheritance, mitotic cytokinesis, and platelet aggregation all depend on dynamic cytoskeletal remodeling and vesicle trafficking. Some terms are obsolete, but the shared theme is cytoskeletal dynamics linked to membrane trafficking.","confidence":"Medium","size":9,"edges":29,"triangles":51,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001300","count":5},{"id":"GO:0030240","count":5},{"id":"GO:1904623","count":5},{"id":"GO:0048741","count":5},{"id":"GO:0030100","count":5}]},{"hash":"2264617476495619893","title":"ER-Golgi Membrane Trafficking","description":"This cluster is dominated by GO terms tied to the secretory pathway and organelle organization: protein homooligomerization, ER membrane fusion, and protein retention in the Golgi point to roles in ER/Golgi membrane dynamics and trafficking. While apoptosis and cell division terms appear, the strongest signals center on membrane remodeling and trafficking through the ER-Golgi axis, with ancillary hints toward synaptic assembly and neural development that can be linked to membrane trafficking at synapses. Overall, the core theme is intracellular membrane trafficking and organelle organization.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":8},{"id":"GO:0016320","count":5},{"id":"GO:0045053","count":5},{"id":"GO:0006915","count":4},{"id":"GO:0051301","count":4}]},{"hash":"60385868224082363","title":"Embryonic organ morphogenesis","description":"Most top GO terms relate to developmental processes and morphogenesis of diverse organs (heart, hindlimb, eye, placenta, gonads, prostate, habenula). While tissues vary, the common theme is embryonic organ formation and tissue morphogenesis, suggesting the proteins participate in developmentally regulated morphogenetic pathways.","confidence":"Medium","size":9,"edges":7,"triangles":4,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043433","count":8},{"id":"GO:2000288","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0021986","count":8},{"id":"GO:0003148","count":8}]},{"hash":"2211163894522378200","title":"Meiosis and chromatin silencing","description":"The top GO terms cluster around meiotic processes (premeiotic DNA replication, late meiotic recombination nodules, MCM complex assembly) and chromatin regulation/heterochromatin formation (silent mating-type cassette heterochromatin formation, subtelomeric heterochromatin formation), suggesting a cohesive theme of meiosis coupled with chromatin silencing. A couple of terms about cilium movement and cochlea development appear less related and may reflect annotation noise, but the dominant signal supports a meiotic/chromatin-focused function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":3},{"id":"GO:0003341","count":2},{"id":"GO:0090102","count":2},{"id":"GO:1990048","count":2},{"id":"GO:1902450","count":2}]},{"hash":"1110510506825481157","title":"MAPK signaling negative regulation","description":"The GO terms cluster around negative regulation of ERK1/ERK2 cascade, JNK activity, and broader signaling attenuation via peptidyl-tyrosine dephosphorylation, suggesting proteins that dampen MAPK pathway activity (with links to T cell signaling, VEGF signaling, and development). This makes MAPK pathway inhibition the most coherent umbrella for the cluster.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0035335","count":7},{"id":"GO:0000200","count":6},{"id":"GO:0070373","count":6},{"id":"GO:0050860","count":6},{"id":"GO:1900746","count":5}]},{"hash":"1194069834550218988","title":"MHC Ib lipid antigen presentation and interferon signaling","description":"This cluster centers on immune functions, with evidence for complement activation, defense against bacteria, and both exogenous and endogenous lipid antigen presentation via MHC class Ib, alongside type I interferon signaling and thymic T cell differentiation. The combination suggests a coordinated innate-adaptive immune program focused on lipid antigen handling and antiviral signaling through MHC Ib pathways. ","confidence":"High","size":9,"edges":10,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":6},{"id":"GO:0050829","count":5},{"id":"GO:0050690","count":5},{"id":"GO:0048007","count":5},{"id":"GO:0060337","count":5}]},{"hash":"808157511143467857","title":"RNA Splicing and Processing Machinery","description":"The top GO terms are dominated by mRNA splice site recognition and spliceosome-related activity, with additional support from tRNA processing, indicating the cluster mainly comprises RNA splicing/processing proteins. A few outlier terms pertain to development or immune functions, likely reflecting broader roles or pleiotropy rather than core function of the cluster.","confidence":"High","size":9,"edges":19,"triangles":18,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006376","count":4},{"id":"GO:0045843","count":4},{"id":"GO:0000388","count":1},{"id":"GO:0010226","count":1},{"id":"GO:0008033","count":1}]},{"hash":"1010425691356161821","title":"RNA Polymerase II Transcription Regulation","description":"This cluster is dominated by GO terms about transcription by RNA polymerase II, including DNA-templated transcription and negative regulation of RNAP II transcription, indicating a transcription-regulation theme. Some developmental terms appear but are less representative, likely noise or broader roles.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046022","count":7},{"id":"GO:0007576","count":7},{"id":"GO:0010729","count":7},{"id":"GO:0070895","count":7},{"id":"GO:0006351","count":7}]},{"hash":"1482751071335897968","title":"Immune activation and T cell signaling","description":"The Top Terms show a clear tilt toward immune-related processes: innate immune response, defense response to Gram-positive bacteria, and T cell receptor signaling are represented, suggesting the cluster centers on immune activation. Additional terms like positive regulation of ERK1/ERK2 cascade and positive regulation of xenophagy point to signaling and autophagy pathways involved in immune responses. While developmental terms such as nervous system development and multicellular organism development appear, they are less dominant, so the core theme remains immune signaling with supportive autophagy and MAPK regulation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0000902","count":2},{"id":"GO:1904417","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0050830","count":2}]},{"hash":"142089476356631621","title":"Unknown","description":"The top GO terms are a mix of translation initiation-related processes and various development and cellular processes (retina, skeletal system, male gonad development; actin dynamics; cytokinesis; ubiquitin-related deubiquitination). With no edges and a broad, non-cohesive set of functions, there isn\u2019t a single clear theme tying these proteins together.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0071560","count":3},{"id":"GO:0060041","count":3},{"id":"GO:0008584","count":3}]},{"hash":"907194579366351229","title":"Pyrimidine Nucleotide Salvage","description":"This cluster shows strong representation of pyrimidine salvage processes (CMP, CTP, UMP and uracil salvage) and related pyrimidine metabolism, indicating a coordinated role in nucleotide salvage. Coenzyme A biosynthesis and transcription-related terms are present but seem less central to the cluster\u2019s core function. The label focuses on the clearest shared theme among the dominant GO terms.","confidence":"Medium","size":9,"edges":12,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0015937","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0006238","count":1},{"id":"GO:0044211","count":1}]},{"hash":"2246030396199650339","title":"Neuronal development and actin cytoskeleton remodeling","description":"The Top Terms show clear signals for neuronal development and neuron projection morphogenesis, while several terms point to actin cytoskeleton dynamics (actin crosslink formation, actin filament polymerization, and Rho signaling regulation). This suggests the cluster centers on neural differentiation and shaping neuron morphology via actin-based remodeling, with a few transcription-related and stress-response terms present as broader contextual functions. ","confidence":"Medium","size":9,"edges":9,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048666","count":2},{"id":"GO:0031424","count":1},{"id":"GO:0048096","count":1},{"id":"GO:0006368","count":1},{"id":"GO:1903912","count":1}]},{"hash":"1644707993473717331","title":"Neuronal synaptic transmission and mitochondrial regulation","description":"This cluster centers on neuronal communication: neurotransmitter secretion/transport, synaptic vesicle exocytosis, and synaptic plasticity/learning. The presence of mitochondrial-related terms (protein import into the mitochondrial matrix and regulation of mitophagy) suggests mitochondrial involvement in these neuronal processes, reinforcing a synaptic/neuronal function theme. Some terms like insulin secretion and epithelial differentiation are peripheral but do not outweigh the core neuronal secretory/plasticity signal.","confidence":"Medium","size":9,"edges":9,"triangles":1,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0046928","count":2},{"id":"GO:0006836","count":2},{"id":"GO:0031915","count":2},{"id":"GO:0016079","count":2},{"id":"GO:0030073","count":2}]},{"hash":"1207946430367165970","title":"Chromatin remodeling and transcription regulation","description":"The cluster centers on nuclear chromatin dynamics and transcription control, as shown by recurring GO terms for transcriptional regulation by RNA polymerase II, transcription initiation-coupled chromatin remodeling, rDNA heterochromatin formation, and DNA replication\u2013dependent chromatin assembly, along with nucleus organization. While a few terms (e.g., certain developmental or defense processes) appear, they likely reflect multi-functionality or annotation spillover of chromatin-associated proteins. This suggests a coherent module of chromatin regulation and transcriptional control.","confidence":"High","size":9,"edges":32,"triangles":60,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0000183","count":7},{"id":"GO:0045815","count":7},{"id":"GO:0051290","count":7},{"id":"GO:0006335","count":7}]},{"hash":"1661031270348468704","title":"Heat-Response Proteostasis and ERAD","description":"Top terms point to protein quality control under heat stress, especially ubiquitin-dependent ERAD and misfolded protein transport, with supporting signals in translation quality control and regulation of proteostasis-related activities. This suggests a coherent theme of maintaining proteome integrity during heat stress by targeting misfolded proteins for degradation, with some ancillary connections to related cellular regulation. Some terms (e.g., axonemal assembly) may be peripheral or reflect broader chaperone-related roles.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0070317","count":3},{"id":"GO:0009408","count":3},{"id":"GO:0006469","count":2},{"id":"GO:1900035","count":2}]},{"hash":"149582027603524475","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045944","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0006311","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0001666","count":2}]},{"hash":"361285971452927259","title":"Transcriptional Regulation and Development","description":"The top GO terms are dominated by transcription-related processes (DNA-templated transcription; negative regulation of transcription by RNA polymerase II) and nucleolar fragmentation, suggesting a cluster of transcription regulators. A couple of terms refer to development (leaf and brain) and metabolism (BH4 and dihydrofolate), which may reflect broader roles or annotation noise. Overall, transcriptional regulation is the most representative theme for this cluster, with some developmental context.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0070895","count":2},{"id":"GO:0046022","count":2},{"id":"GO:0007576","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0010729","count":2}]},{"hash":"1094311130863073581","title":"Unknown","description":"The top GO terms cover membrane trafficking (caveolin-mediated endocytosis), signaling (JNK activity regulation), metabolism (cytosine and sphingolipid processes), development (CNS neuron development), proliferation regulation in different tissues, centrosome cycle, and responses to IL-7, with no single cohesive biological function tying all proteins together. Thus there isn\u2019t a clear, shared theme for a specific label beyond a broad, multi-functional set. ","confidence":"","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0072584","count":9},{"id":"GO:0033598","count":9},{"id":"GO:1990804","count":9},{"id":"GO:0007098","count":9},{"id":"GO:0043506","count":9}]},{"hash":"233847398273283966","title":"Embryonic Morphogenesis and Patterning","description":"The top GO terms cluster around developmental morphogenesis and patterning\u2014cartilage morphogenesis, left/right pattern formation, hair follicle morphogenesis, roof of mouth development, and placenta-related differentiation\u2014suggesting the proteins are enriched for embryonic tissue development. Other terms (RNA polymerase II regulation, mRNA splicing, ribosomal export, DNA replication initiation) are broader cellular processes that accompany development. Overall, the dominant theme is embryonic morphogenesis and body plan patterning.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":8},{"id":"GO:0060972","count":8},{"id":"GO:1903026","count":8},{"id":"GO:0000055","count":8},{"id":"GO:0060806","count":8}]},{"hash":"1948752771631868504","title":"Innate Immune Signaling and NF-\u03baB/ERK Pathways","description":"The top GO terms center on innate immune response and immune signaling, including B cell receptor signaling, NF-\u03baB activation, and ERK cascade, with related cytokine production and angiogenesis. A few terms touch nervous system development, but the dominant signal is immune pathway activity, suggesting proteins involved in innate/adaptive immune signaling and downstream NF-\u03baB/ERK signaling.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0051092","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0050853","count":5},{"id":"GO:0010863","count":5}]},{"hash":"1058497708623763776","title":"Innate immune activation and leukocyte recruitment","description":"The top GO terms cluster around innate immune responses and leukocyte activity (eosinophil degranulation, neutrophil killing of bacteria, dendritic cell chemotaxis, LPS response), indicating a shared immune signaling function. Some development terms are present but do not define the core function of the cluster.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":9},{"id":"GO:0060427","count":9},{"id":"GO:0070963","count":9},{"id":"GO:0051482","count":9},{"id":"GO:0060041","count":9}]},{"hash":"1201887386762932287","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms point to development and morphogenesis across tissues (heart development, embryonic morphogenesis, imaginal disc-derived morphogenesis) and neuronal guidance (axon guidance, chemorepulsion). There are also some immune-regulatory terms (negative regulation of IL-1 signaling, NK cell cytotoxicity regulation), but the dominant signal is developmental processes and cell movement/migration. This suggests a cohesive theme around developmental morphogenesis and tissue shaping rather than a single enzymatic pathway.","confidence":"Medium","size":9,"edges":30,"triangles":47,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:2000660","count":2},{"id":"GO:0072277","count":2},{"id":"GO:0035701","count":2},{"id":"GO:0002859","count":2},{"id":"GO:0050927","count":2}]},{"hash":"473809754087722067","title":"Unknown","description":"The GO terms span many organs and processes (kidney development, skin development, enamel formation, muscle regulation, oligodendrocyte differentiation, learning, hypoxia response, neuronal plasticity, and general cell communication), with no single cohesive biological function tying the cluster together. This diversity suggests there isn\u2019t a clear, shared theme among these proteins that would justify a specific, meaningful label beyond Unknown.","confidence":"","size":9,"edges":8,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0003338","count":2},{"id":"GO:0014819","count":2},{"id":"GO:0048709","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0007612","count":2}]},{"hash":"1966297033937083421","title":"Unknown","description":"Top terms span various immune and developmental processes (eosinophil/neutrophil activity, dendritic cell chemotaxis, response to LPS, lung/heart/retina development, endothelial barrier regulation, GPCR signaling). The lack of a unifying function and no observed edges among proteins prevents a cohesive, specific label, so the cluster is Unknown with no confidence.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":9},{"id":"GO:0060427","count":9},{"id":"GO:0070963","count":9},{"id":"GO:0051482","count":9},{"id":"GO:0060041","count":9}]},{"hash":"1473373056368813395","title":"NF-kB and ubiquitin signaling","description":"The dominant GO terms cluster around NF-kappaB signaling and TNF-mediated pathways, with strong emphasis on ubiquitin-dependent processes (protein autoubiquitination, ERAD). This suggests a core theme of inflammatory signaling regulated by ubiquitination and NF-kB activity, with a few peripheral terms related to autophagy and vesicle transport. ","confidence":"High","size":8,"edges":21,"triangles":30,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1903265","count":5},{"id":"GO:0051865","count":5},{"id":"GO:0030433","count":5},{"id":"GO:1901097","count":4},{"id":"GO:0010216","count":4}]},{"hash":"1204959152697494477","title":"Neuronal development and endocytosis regulation","description":"The top GO terms are dominated by nervous system development and positive regulation of neuron projection development, suggesting a neuron-centric module. Additional terms point to membrane trafficking (endocytosis/pinocytosis regulation) and signaling (protein autophosphorylation), consistent with neuronal signaling and endocytic processes; nucleotide biosynthesis terms may reflect general metabolism but do not define the core theme. ","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006228","count":5},{"id":"GO:0002762","count":5},{"id":"GO:0048550","count":5},{"id":"GO:0006897","count":5},{"id":"GO:0007399","count":5}]},{"hash":"653690044808516428","title":"Golgi-ER vesicle transport","description":"The dominant GO terms point to vesicle trafficking between the ER and Golgi and within Golgi compartments (inter-Golgi cisterna transport and ER-to-Golgi transport), as well as protein retention in the Golgi. This suggests the cluster centers on Golgi/ER trafficking and Golgi protein handling, with some auxiliary signals (stress granule disassembly, peroxisome import) likely reflecting broader trafficking or processing roles. Overall, a Golgi/ER vesicle transport theme fits best.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048219","count":2},{"id":"GO:0035617","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0072389","count":1},{"id":"GO:0051131","count":1}]},{"hash":"1511235457641100142","title":"Serine/threonine and cysteine sulfur metabolism","description":"The cluster's top GO terms point to serine/threonine metabolism, cysteine biosynthesis via transsulfuration, and hydrogen sulfide production, forming a coherent module of sulfur-containing amino acid metabolism.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006069","count":3},{"id":"GO:0006068","count":3},{"id":"GO:0042572","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006565","count":3}]},{"hash":"193738143273884568","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006096","count":6},{"id":"GO:0009089","count":6},{"id":"GO:0042823","count":6},{"id":"GO:0051402","count":6},{"id":"GO:0055114","count":6}]},{"hash":"1533315135304484127","title":"Energy metabolism and stress responses","description":"Cluster appears enriched for energy and nutrient metabolism: glycogen biosynthesis, branched-chain amino acid (valine/leucine) catabolism, fatty acid beta-oxidation, and carnitine metabolism, along with responses to starvation and cold. This points to a cohesive theme of energy production and metabolic regulation under nutrient stress. A few terms like heart development and ascaroside biosynthesis seem less directly connected and may reflect annotation breadth or cross-species associations.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":3},{"id":"GO:0006574","count":3},{"id":"GO:1904070","count":2},{"id":"GO:0033539","count":2},{"id":"GO:0007507","count":2}]},{"hash":"2032080337282354923","title":"Amino acid catabolism and central carbon metabolism","description":"Most of the top GO terms cluster around amino acid catabolic pathways (L-alanine, L-kynurenine, L-lysine) and core energy metabolism (glycolytic process, TCA cycle, oxaloacetate metabolism). This points to a metabolic module focused on amino acid breakdown and downstream energy production. Notch signaling and response to cAMP appear less central in this set, suggesting incidental associations rather than defining features of the cluster.","confidence":"High","size":8,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042853","count":3},{"id":"GO:0007219","count":3},{"id":"GO:0097053","count":3},{"id":"GO:0051591","count":3},{"id":"GO:0006096","count":2}]},{"hash":"609388505442517959","title":"DNA Damage Response and Transcription Regulation","description":"This cluster is dominated by GO terms related to DNA-templated transcription, DNA replication, and DNA repair, along with the SOS response, indicating a core nuclear program for genome maintenance and transcription control. The presence of hypoxia/angiogenesis terms suggests a broader stress-response context, while a couple of terms are obsolete, which may reflect annotation drift. Overall, the proteins likely participate in DNA damage response and transcription regulation under cellular stress.","confidence":"Medium","size":8,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0006465","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0019044","count":2}]},{"hash":"1081749707089427046","title":"Skeletal Muscle Development and Cytoskeletal Dynamics","description":"The cluster prominently features GO terms related to skeletal muscle fiber development and thin filament assembly, pointing to muscle formation. Additional terms about regulation of endocytosis and platelet aggregation suggest broader cytoskeletal (actin-based) remodeling and vesicle trafficking functions common to muscle cells and platelets, reinforcing a cohesive theme of cytoskeletal dynamics in muscle and related cell types. Some terms are obsolete, but the core signal centers on muscle development and actin-based organization.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001300","count":6},{"id":"GO:0030240","count":6},{"id":"GO:1904623","count":6},{"id":"GO:0048741","count":6},{"id":"GO:0030100","count":6}]},{"hash":"1626471088704574150","title":"Dendritic Spine Morphogenesis and Actin Organization","description":"The top terms cluster around neuronal spine development and actin cytoskeleton remodeling (dendritic spine morphogenesis and actin cytoskeleton organization), with a signaling note from calcium release into cytosol. This points to a functional theme of synaptic structure formation and cytoskeletal dynamics, despite some noisy/obsolete terms. ","confidence":"High","size":8,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051289","count":2},{"id":"GO:0060997","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0051209","count":1},{"id":"GO:0006369","count":1}]},{"hash":"1157342277044278149","title":"Neuronal morphogenesis and neurotransmitter release","description":"GO terms show a pattern of neuronal development and synaptic activity: regulation of filopodium assembly, branching morphogenesis of a nerve, auditory receptor morphogenesis, and evoked neurotransmitter secretion. Other terms touch cytoskeletal organization and autophagy/ubiquitination, but the strongest, recurrent themes relate to neuron structure formation and signaling, supporting a neuronal morphogenesis and neurotransmission cluster.","confidence":"Medium","size":8,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0031321","count":2},{"id":"GO:0016567","count":2},{"id":"GO:1901097","count":2},{"id":"GO:0002093","count":1},{"id":"GO:0031578","count":1}]},{"hash":"1288265295769767291","title":"Neural development and axon guidance","description":"This cluster highlights neural development signals, with terms like corticospinal neuron axon guidance through spinal cord and regulation of branching morphogenesis of a nerve, plus related cellular responses to mechanical stimuli. The presence of signaling regulation terms (negative regulation of protein kinase activity, TLR5 signaling) supports a theme of coordinated signaling during neural growth and pathfinding. Some development terms for other organs appear, but neural-related terms are most prominent. Confidence: Medium","confidence":"","size":8,"edges":8,"triangles":0,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006469","count":6},{"id":"GO:0060427","count":5},{"id":"GO:0016239","count":5},{"id":"GO:0048833","count":5},{"id":"GO:0048681","count":5}]},{"hash":"298902848732402552","title":"Ribosome biogenesis and translation","description":"This cluster is centered on ribosome assembly and the protein synthesis machinery, reflected by enrichment for ribosome biogenesis and translation-related GO terms (translation, translation initiation, translation reinitiation) plus RNA processing steps like rRNA and snRNA pseudouridine synthesis and LSU-rRNA maturation. The presence of translation-related regulation terms, including negative regulation of nonsense-mediated decay and positive regulation of selenocysteine incorporation, suggests coordinated control of translation and ribosome function. Overall, the proteins likely participate in ribosome biogenesis and the translation process.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0007338","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0031120","count":3},{"id":"GO:0031118","count":3}]},{"hash":"1657801214671050213","title":"Protein quality control and trafficking","description":"These proteins show enrichment for intracellular transport and proteostasis-related processes, including vesicle fusion with the Golgi, general intracellular protein transport, aggrephagy, and ubiquitin/proteasome-related activity. Taken together, the dominant themes are protein turnover and cargo trafficking within the cell, with a few terms touching on development or RNA silencing that are less central to the core signal. ","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032781","count":2},{"id":"GO:0048280","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0035278","count":2},{"id":"GO:2000157","count":1}]},{"hash":"974081646988750132","title":"Antigen processing and proteolysis","description":"The cluster\u2019s top terms center on antigen processing and presentation via MHC class II and on proteolytic activities (membrane proteolysis, protein autoprocessing, general proteolysis, digestion). This suggests a core theme of proteolytic processing of proteins feeding antigen presentation, with some other terms possibly reflecting broader roles of proteases. Overall, the dominant signal is proteolysis linked to antigen processing.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0019886","count":4},{"id":"GO:0042985","count":3},{"id":"GO:0070305","count":3},{"id":"GO:0033619","count":3},{"id":"GO:0016540","count":3}]},{"hash":"2192931994073539868","title":"Neural and Eye Development with Vascular Morphogenesis","description":"The Top GO terms cluster around developmental and morphogenetic processes affecting neural/eye tissues (optic nerve morphogenesis, retinal ganglion cell axon guidance, myotube differentiation) and vascular formation (endothelial tube lumen extension), with supporting roles for cell adhesion and signaling (integrin regulation, Rho signaling). While there are a few more general terms like apoptotic processes and piRNA processing, the dominant theme centers on developmental differentiation and tissue morphogenesis across neural/eye and vascular contexts, justifying a label focused on neural/eye development and vascular morphogenesis.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0060044","count":3},{"id":"GO:0071372","count":3},{"id":"GO:0035024","count":3},{"id":"GO:0033628","count":3}]},{"hash":"1022365484276665622","title":"Mitochondrial lipid biosynthesis and remodeling","description":"The top GO terms are dominated by lipid biosynthetic and remodeling processes (triglyceride, ether lipid, cutin, cardiolipin remodeling, and CDP-diacylglycerol biosynthesis), with support from mitochondrial ATP synthesis, pointing to lipid metabolism tied to mitochondrial membrane biology. The immune-related terms appear less central to the shared function and may reflect annotation noise. ","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019432","count":5},{"id":"GO:0008611","count":5},{"id":"GO:0010143","count":5},{"id":"GO:0042775","count":5},{"id":"GO:0035965","count":5}]},{"hash":"1658412888257366433","title":"Rho GTPase\u2013driven cytoskeleton and junction assembly","description":"The terms cluster around Rho/GTPase\u2013regulated cytoskeletal remodeling, adherens junction assembly, and membrane trafficking/localization (microvillus and zonula adherens assembly, intracellular transport, and synaptic localization), suggesting a cohesive role in cytoskeleton-driven cell surface organization and trafficking.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030033","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0009395","count":1},{"id":"GO:0035418","count":1}]},{"hash":"2149517708855161068","title":"Schwann cell development and PNS myelination","description":"The top GO terms point strongly to Schwann cell biology and peripheral nervous system myelination (Schwann cell development; myelination in peripheral nervous system), with EMT also echoing neural crest\u2013derived glial differentiation. While other terms are more general (cell cycle, DNA repair), the core theme centers on glial development and myelination in the PNS.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0005981","count":8},{"id":"GO:1905205","count":8},{"id":"GO:2001034","count":8},{"id":"GO:0001837","count":8},{"id":"GO:0014044","count":8}]},{"hash":"2212557637974820657","title":"Cell organization and vesicle dynamics","description":"The top GO terms cluster around vesicle assembly/inheritance (Cvt vesicle, vacuole inheritance), cell\u2013cell adhesion (desmosome assembly), and intracellular regulation (ER calcium, chromatin remodeling), with a backdrop of development-related processes (vasculogenesis, renal vesicle formation) and cell fate (apoptotic regulation). This points to a module governing cellular architecture, trafficking, and structural organization, rather than a single precise pathway.","confidence":"Medium","size":8,"edges":27,"triangles":50,"max_degree":7,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":7},{"id":"GO:0000011","count":6},{"id":"GO:0002159","count":6},{"id":"GO:0048096","count":6},{"id":"GO:0071255","count":6}]},{"hash":"14398235419294732","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":19,"triangles":19,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006547","count":8},{"id":"GO:0072356","count":8},{"id":"GO:0051036","count":8},{"id":"GO:1905490","count":8},{"id":"GO:1905869","count":8}]},{"hash":"224796563079612017","title":"mRNA Splicing and Processing Machinery","description":"This cluster is dominated by GO terms for spliceosome-mediated mRNA splicing, regulation of splicing, mRNA export, and mRNA stability, indicating proteins involved in mRNA processing and spliceosome function.","confidence":"High","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":6},{"id":"GO:0048026","count":5},{"id":"GO:0031047","count":5},{"id":"GO:0010610","count":5},{"id":"GO:0048255","count":5}]},{"hash":"662574887461927254","title":"Cell growth and developmental signaling","description":"The proteins map to a mix of growth, proliferation, development, and signaling processes (centrosome cycle, JNK regulation, various proliferation terms, neuron development, and endocytosis/metabolism tasks), suggesting a broad theme around cellular growth and developmental signaling rather than a single, precise pathway.","confidence":"Medium","size":8,"edges":18,"triangles":21,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007118","count":8},{"id":"GO:0072584","count":6},{"id":"GO:0033598","count":6},{"id":"GO:1990804","count":6},{"id":"GO:0007098","count":6}]},{"hash":"7241672325529682","title":"mRNA Splicing, Processing, and Export","description":"This cluster centers on spliceosome-mediated mRNA splicing, splice-site recognition, poly(A) tail regulation, mRNA stability, and nuclear export, indicating proteins involved in mRNA maturation and transport; regulatory ncRNA silencing is also represented but remains within RNA-level regulation.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":5},{"id":"GO:0031047","count":5},{"id":"GO:0006378","count":5},{"id":"GO:0010610","count":4},{"id":"GO:0048255","count":4}]},{"hash":"2063104121940957825","title":"Auditory hair cell development and calcium signaling","description":"The top terms cluster around cochlea and inner ear receptor cell development, together with ion transport (sodium and calcium) and calcium-responsive signaling, which are central to hair cell function in the auditory system. The presence of GABA signaling and startle response supports a link to auditory processing and neural signaling, while circadian-related terms may reflect broader neuromodulatory contexts. Overall, this points to an auditory/hair-cell\u2013associated signaling cluster. ","confidence":"Medium","size":8,"edges":11,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0098703","count":4},{"id":"GO:0045188","count":4},{"id":"GO:0001964","count":4},{"id":"GO:0051592","count":3}]},{"hash":"690553773266642375","title":"Retinal neuron development and vesicle trafficking","description":"The cluster centers on neural/retinal development (brain development, photoreceptor development, bipolar cell growth) and secretory/vesicle transport processes (ER-to-Golgi transport, synaptic vesicle budding) with supportive cytoskeletal organization (tubulin assembly) and cell polarity, suggesting a combined program for retinal neuron differentiation and intracellular trafficking.","confidence":"Medium","size":8,"edges":14,"triangles":5,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0007420","count":7},{"id":"GO:0006888","count":7},{"id":"GO:0007021","count":6},{"id":"GO:0042461","count":6}]},{"hash":"697107080635183736","title":"Immune signaling and angiogenesis","description":"The cluster is dominated by immune signaling terms (B cell receptor, Fc-epsilon receptor, type I interferon signaling, IL-2 production) and related growth/mitogenic pathways (ERK, PI3K, Kit) plus angiogenesis, suggesting a signaling network coordinating immune responses with vascular growth cues.","confidence":"Medium","size":8,"edges":23,"triangles":31,"max_degree":7,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0001525","count":8},{"id":"GO:0070374","count":8},{"id":"GO:0043552","count":8},{"id":"GO:0038109","count":8},{"id":"GO:1900042","count":8}]},{"hash":"534489624175860642","title":"Nuclear mRNA processing and export","description":"This cluster centers on nuclear RNA processing and post-transcriptional regulation, with emphasis on mRNA splicing, splice site recognition, mRNA stabilization, export from the nucleus, and regulation of poly(A) tail shortening, plus ncRNA-mediated gene silencing. These terms together suggest a cohesive theme of coordinated mRNA maturation and control within the nucleus.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":7},{"id":"GO:0048026","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0048255","count":6},{"id":"GO:0006376","count":6}]},{"hash":"1533309944446741238","title":"Hormone-regulated transcription and development","description":"This cluster shows a mix of transcriptional regulation and hormone-responsive developmental processes: DNA-templated transcription is prominent, and several GO terms point to hormone signaling (estrogen receptor, ecdysone receptor) and tissue development (Leydig cell differentiation, mammary gland alveolus development, liver regeneration). The presence of apoptotic regulation and circadian gene expression suggests broader gene-expression control in response to hormonal and developmental cues. Taken together, the proteins seem linked by a theme of transcriptional control modulated by hormonal signals during development and tissue remodeling.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0010875","count":3},{"id":"GO:0097421","count":2},{"id":"GO:0033327","count":2},{"id":"GO:0060749","count":2}]},{"hash":"1098950922923166193","title":"Unknown","description":"The top GO terms are highly diverse: DNA-templated transcription, cadmium ion response, cytokinesis regulation, forebrain/spinal cord development, ERAD pathway, mitotic cell cycle, TORC1 signaling, and actin nucleation regulation. This lack of a single cohesive function across the cluster suggests there isn\u2019t a clear unifying theme to confidently label the group.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0071276","count":4},{"id":"GO:0032466","count":4},{"id":"GO:0030900","count":4},{"id":"GO:0030433","count":4}]},{"hash":"456843918144440946","title":"Hair cycle and keratinization","description":"The top terms are strongly skin- and keratinocyte-related: hair cycle, keratinization, and skin development, indicating processes in hair follicles and epidermal differentiation. Ion transport terms appear secondary, not defining a distinct cluster function. Thus, the cluster is best labeled around keratinocyte/hair follicle biology.","confidence":"High","size":8,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042633","count":7},{"id":"GO:0031424","count":7},{"id":"GO:0002724","count":1},{"id":"GO:0010961","count":1},{"id":"GO:0043588","count":1}]},{"hash":"1760697664607797666","title":"Synaptic signaling and plasticity","description":"The top terms cluster around neuronal signaling and synaptic plasticity, including positive regulation of Wnt signaling in neurons, ERK/MAPK cascade, excitatory postsynaptic potentials, learning, and cytoskeletal changes linked to synapse formation. Although an immune signaling term (T cell receptor signaling) appears, the dominant theme is neuronal communication and plasticity.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":6},{"id":"GO:0043525","count":6},{"id":"GO:0051489","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0060079","count":4}]},{"hash":"545890073702437820","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090200","count":1},{"id":"GO:0097193","count":1},{"id":"GO:0034393","count":1},{"id":"GO:0043280","count":1},{"id":"GO:0097222","count":1}]},{"hash":"70495877499394392","title":"Unknown","description":"The GO terms are highly heterogeneous (viral process, ethylene response, NAD+ and CoA biosynthesis, DNA repair, dephosphorylation, various phosphorylations, phototaxis, and a developmental term), with no clear single function or pathway tying the proteins together, suggesting annotation noise or a mixed cluster rather than a cohesive biological theme.","confidence":"","size":8,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":2},{"id":"GO:0009723","count":2},{"id":"GO:0009435","count":1},{"id":"GO:0015937","count":1},{"id":"GO:0006281","count":1}]},{"hash":"618265210001190682","title":"Transcription Regulation and Cellular Stress Response","description":"The cluster features GO terms for regulation of DNA-templated transcription and Rho signaling, plus stress-related responses (misfolded protein, arsenic exposure), suggesting proteins that modulate gene expression in response to cellular stress. Some developmental terms appear as outliers, but the common theme centers on transcriptional control coupled with stress signaling.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001662","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0090309","count":2},{"id":"GO:0051567","count":2}]},{"hash":"17885251428333399","title":"Membrane remodeling and signaling","description":"The terms cluster around membrane-associated processes: lipid metabolism and dolichyl lipid pathways, membrane repair, vesicle localization, and receptor signaling (BCR, VEGF), as well as a note on myoblast fusion. This points to a membrane-centric functional theme influencing signaling and fusion events.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0009395","count":8},{"id":"GO:0090153","count":8},{"id":"GO:0010794","count":8},{"id":"GO:0007520","count":8},{"id":"GO:0043065","count":8}]},{"hash":"1868249805808803924","title":"RNA Modification and Transcription Machinery","description":"Based on the GO terms, the strongest signals are RNA modification (rRNA and tRNA methylation, guanine-N7 methylation) and DNA-templated transcription, suggesting a cluster enriched for RNA processing/modification and transcription-related proteins. Some terms (cellular response to lipopolysaccharide, retinal cone cell development, antibiotic-related processes) are less cohesive with the core theme, indicating mixed or divergent functions within the cluster. Overall, the label best captures the dominant RNA modification and transcription-related signals.","confidence":"Medium","size":8,"edges":6,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0046549","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000154","count":2},{"id":"GO:0046677","count":2}]},{"hash":"1365043474926974642","title":"Mammalian embryonic organogenesis","description":"The top GO terms cluster around developmental and organ formation processes in mammals (heart development, ureteric bud development, in utero embryonic development, mammary gland branching). Additional terms touch on differentiation and adhesion-related regulation (myoblast proliferation, foam cell differentiation, integrin biosynthetic regulation), which fit within coordinated tissue development. Despite some obsolete terms, the dominant theme is embryonic organogenesis and developmental differentiation.","confidence":"High","size":8,"edges":9,"triangles":4,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010980","count":8},{"id":"GO:2000288","count":8},{"id":"GO:0072366","count":8},{"id":"GO:0001657","count":8},{"id":"GO:0007507","count":8}]},{"hash":"1337993247117568054","title":"APC/C-Proteasome Mediated Cell Cycle Control","description":"The cluster\u2019s prominent GO terms center on mitosis regulation and protein degradation: APC/C-dependent catabolic processes, spindle assembly checkpoint deactivation, and autoubiquitination, alongside proteasome localization. These collectively point to ubiquitin-proteasome control of the cell cycle. Some terms like JNK signaling and translesion synthesis hint at stress responses, but the strongest signal remains cell-cycle\u2013proteolysis coordination.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1902426","count":8},{"id":"GO:0001701","count":8},{"id":"GO:0010976","count":8},{"id":"GO:1990920","count":8},{"id":"GO:0051569","count":8}]},{"hash":"1385958045139125443","title":"Unknown","description":"The GO terms span diverse metabolic pathways and developmental/epigenetic processes with no single overarching function tying the proteins together, so no cohesive cluster theme can be inferred.","confidence":"","size":8,"edges":8,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0019483","count":8},{"id":"GO:0019383","count":8},{"id":"GO:0030851","count":8},{"id":"GO:0021983","count":8},{"id":"GO:0010725","count":8}]},{"hash":"1119021132358335739","title":"Embryonic Morphogenesis and Organ Development","description":"These terms cluster around embryonic development and tissue formation, including cartilage morphogenesis, left/right patterning, placenta-related differentiation, endocrine system development, pancreatic beta cell development, endocardial cushion EMT, and trophoblast differentiation. The presence of transcriptional regulation terms fits a developmental gene-control context. Together, they point to a cohesive theme of organogenesis and morphogenesis during embryogenesis.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":5,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0060536","count":6},{"id":"GO:0060972","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003323","count":6}]},{"hash":"1241882041960987170","title":"Neural development and synapse formation","description":"This cluster centers on neural development and synaptic biology, with terms like radial glial differentiation, oligodendrocyte progenitor proliferation, and corticospinal tract morphogenesis indicating CNS development, alongside presynaptic active zone assembly, chemical synaptic transmission, and calcium- and neuron adhesion-related terms that reflect synapse formation and connectivity. Some terms such as melanosome transport or follicle cell microvilli length are less related, but the dominant theme is neural development and synaptic organization.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902910","count":8},{"id":"GO:0060019","count":8},{"id":"GO:0070445","count":8},{"id":"GO:0045317","count":8},{"id":"GO:0032533","count":8}]},{"hash":"614777276380027137","title":"Inflammation-driven tissue remodeling and angiogenesis","description":"These proteins collectively point to inflammatory signaling and remodeling of the extracellular matrix, with leukocyte migration, chronic inflammatory responses, and positive regulation of angiogenesis. The presence of LPS response, leukocyte movement, and ECM disassembly suggests a coordinated inflammatory program that drives tissue remodeling and neovascularization, rather than a single isolated pathway.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0002523","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0071333","count":2}]},{"hash":"282251270557556632","title":"Cardiovascular and retinal development with immune signaling","description":"The terms cluster around development of multiple tissues (heart, retina, lung connective tissue) and immune-related activities (eosinophil degranulation regulation, neutrophil killing of gram-negative bacteria, dendritic cell chemotaxis, response to LPS), along with GPCR/cAMP signaling and endothelial barrier regulation. This suggests a theme of developmental processes in cardiovascular/visual tissues with concurrent innate immune signaling.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":8},{"id":"GO:0060427","count":8},{"id":"GO:0070963","count":8},{"id":"GO:0051482","count":8},{"id":"GO:0060041","count":8}]},{"hash":"1842399626719883950","title":"Unknown","description":"The GO terms span diverse roles from organ development (heart, retina, lung connective tissue) to immune responses (eosinophil degranulation, neutrophil killing, dendritic cell chemotaxis, LPS response) and signaling, with no clear, single biological theme tying them together.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":8},{"id":"GO:0060427","count":8},{"id":"GO:0070963","count":8},{"id":"GO:0051482","count":8},{"id":"GO:0060041","count":8}]},{"hash":"341317524839291940","title":"Alzheimer's disease proteostasis and microglia","description":"GO terms center on Alzheimer's disease-related mechanisms (tau tangles, tau kinase activity, amyloid-beta) alongside proteostasis activities (chaperone-mediated folding/assembly and ubiquitin-dependent degradation) and microglial activation, suggesting a cohesive brain proteostasis/inflammation cluster with AD relevance.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070328","count":2},{"id":"GO:0051131","count":1},{"id":"GO:1902998","count":1},{"id":"GO:1902230","count":1},{"id":"GO:1902430","count":1}]},{"hash":"1536388620860767629","title":"Developmental morphogenesis and proteoglycan biosynthesis","description":"This cluster is driven by terms related to tissue development and morphogenesis (embryonic cranial morphogenesis, wing vein specification, mammary gland development) and extracellular matrix composition via proteoglycan biosynthesis (keratan and heparan sulfate). Epithelial migration also supports morphogenesis. While immune terms appear, the core signal points to developmental processes and ECM remodeling.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007427","count":2},{"id":"GO:0018146","count":2},{"id":"GO:0030879","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0002281","count":2}]},{"hash":"1570578268391499248","title":"Developmental signaling and ECM remodeling","description":"The GO terms cluster around developmental processes and regulation of extracellular matrix interactions\u2014branching morphogenesis (ureteric bud), collagen biosynthesis, and cell-matrix adhesion\u2014along with signaling regulation (Smoothened pathway) and differentiation signals (astrocyte differentiation, pregnancy). This suggests proteins involved in coordinating development with tissue remodeling. ","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0045879","count":3},{"id":"GO:0090190","count":3},{"id":"GO:0030308","count":3},{"id":"GO:0032930","count":3}]},{"hash":"2153005301307172854","title":"Coagulation and Morphogenesis Pathways","description":"The cluster's GO terms include coagulation-related processes (Factor XII activation, intrinsic coagulation pathway, and positive regulation of plasminogen activation), suggesting a role in hemostasis and fibrinolysis. Other terms point to development and tissue organization (bone mineralization, foregut morphogenesis, axon guidance, epithelial polarity, and B cell differentiation), indicating multifunctional proteins that participate in morphogenesis and cellular patterning in addition to coagulation. Overall, the terms cluster around both coagulation and developmental/tissue-remodeling themes, supporting a label that captures these combined roles.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0030282","count":3},{"id":"GO:0002542","count":3},{"id":"GO:0021972","count":3},{"id":"GO:0007440","count":3}]},{"hash":"2019343246587625815","title":"Notch receptor processing and signaling","description":"The cluster strongly features GO terms tied to Notch receptor processing, ectodomain and intracellular domain proteolysis, and Notch signaling, with supporting development context (pharynx development) and a link to gamma-secretase\u2013related cleavage (amyloid-beta formation). Some virus-regulation terms appear as noise, but the dominant theme is Notch pathway activation via proteolytic processing.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0072137","count":2},{"id":"GO:0007220","count":1},{"id":"GO:0031293","count":1},{"id":"GO:0006509","count":1},{"id":"GO:0007219","count":1}]},{"hash":"1342269147736010763","title":"Proteoglycan Biosynthesis and Epithelial Polarity","description":"The cluster centers on proteoglycan biosynthesis (keratan sulfate, heparan sulfate, chondroitin sulfate) and the establishment of epithelial cell polarity, with developmental context. These connect to ECM components guiding epithelial organization and morphogenesis; other metabolic terms are more peripheral but not conflicting.","confidence":"Medium","size":8,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":2},{"id":"GO:0018146","count":1},{"id":"GO:0015015","count":1},{"id":"GO:0048702","count":1},{"id":"GO:0009812","count":1}]},{"hash":"41129272661755756","title":"Chromatin regulation and transcription control","description":"This cluster centers on nuclear regulation of gene expression: terms like negative regulation of transcription elongation by RNA polymerase II, protein localization to chromatin, and regulation of histone acetylation point to chromatin-associated transcriptional control. The G1 to G0 transition suggests links to cell-cycle exit and differentiation, which often involve chromatin-mediated regulation of transcription. Some terms reflect developmental or stress-response contexts, but the core signal is chromatin- and transcription-focused regulation.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":3},{"id":"GO:0045128","count":1},{"id":"GO:0070314","count":1},{"id":"GO:0014013","count":1},{"id":"GO:1904772","count":1}]},{"hash":"238463100495583762","title":"Neural development and cytoskeleton remodeling","description":"This cluster isDriven by neural development terms (forebrain development; neurotrophin TRK receptor signaling) and cytoskeletal dynamics (barbed-end actin filament capping; lamellipodium morphogenesis). Additional growth factor responses (HGF, TGF-beta) and ER-to-Golgi transport support a broader signaling/trafficking theme, while cell-cycle terms are more general. Overall, the strongest pattern links neural development with actin-mediated motility and related signaling.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030900","count":3},{"id":"GO:0048011","count":3},{"id":"GO:0051016","count":2},{"id":"GO:2000394","count":2},{"id":"GO:0035729","count":2}]},{"hash":"1850570318838114030","title":"ER-Golgi Vesicle Transport and Secretion","description":"The top GO terms point to components and processes of the secretory pathway\u2014ER to Golgi transport, COPI-coated vesicle budding, ER exit, and Golgi ribbon formation, as well as regulation of Wnt secretion and ER retention. These collectively define vesicle trafficking and protein secretion, with neutrophil degranulation and complement activation likely reflecting downstream secreted mediators or immune-related roles, but not altering the central theme. Therefore, a concise label is ER-Golgi Vesicle Transport and Secretion.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0043312","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0007157","count":2}]},{"hash":"2147510972400767379","title":"Triglyceride storage and lipid droplet dynamics","description":"The cluster shows multiple GO terms tied to triglyceride biosynthesis, storage, lipid droplet organization, and intracellular triglyceride homeostasis, suggesting a core function in lipid storage/metabolism; some unrelated terms (mitochondrial ribosome assembly, neuronal stem cell maintenance, T cell differentiation) may reflect broad GO associations or annotation noise.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":2},{"id":"GO:0010866","count":1},{"id":"GO:0034389","count":1},{"id":"GO:0030730","count":1},{"id":"GO:0035356","count":1}]},{"hash":"1817661650594427958","title":"Craniofacial and hair follicle morphogenesis","description":"Dominated by morphogenesis and patterning terms for craniofacial structures (cartilage, palate) and hair follicles, with left/right pattern formation, suggesting a cluster focused on craniofacial and integumentary development.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060536","count":8},{"id":"GO:0060972","count":8},{"id":"GO:1903026","count":8},{"id":"GO:0006351","count":8},{"id":"GO:0000055","count":8}]},{"hash":"2240819232770526469","title":"Biosynthesis and RNA Methylation Enzymes","description":"The proteins show enrichment in various biosynthetic processes (pyruvate, lipoate, menaquinone, adenosine metabolism) and RNA methylation (tRNA and rRNA), along with phosphorylation events, suggesting a cluster of enzymes involved in biosynthesis and RNA modification rather than a single specific pathway. The presence of an outlier term like 'female gonad development' likely reflects annotation noise. Therefore, 'Biosynthesis and RNA Methylation Enzymes' is a concise representation.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042866","count":2},{"id":"GO:0008585","count":2},{"id":"GO:0006195","count":1},{"id":"GO:0046085","count":1},{"id":"GO:0016311","count":1}]},{"hash":"894273572022836052","title":"Detoxification and Metabolic Pathways","description":"The GO terms show diverse metabolism (glycolysis, amino acid biosynthesis, cofactor metabolism) plus detoxification (mercury ion) and xenobiotic degradation (camphor), suggesting the proteins are involved in general metabolic functions with redox/detox roles rather than a single pathway.","confidence":"Medium","size":7,"edges":7,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0019483","count":2},{"id":"GO:0006096","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0019383","count":2}]},{"hash":"1417549424181360646","title":"Endocytosis and stress-immune signaling regulators","description":"This cluster features terms tied to regulation of vesicle formation and endocytosis (intralumenal vesicle formation, clathrin-dependent endocytosis), along with components of cellular stress and immune signaling (PML body organization, sumoylation, MyD88-TLR signaling, and responses to cadmium and insecticides). While diverse, the common thread appears to be proteins that modulate trafficking and stress- or immune-related pathways rather than a single canonical function.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1905366","count":7},{"id":"GO:0071276","count":7},{"id":"GO:0030578","count":7},{"id":"GO:1904378","count":7},{"id":"GO:0017085","count":7}]},{"hash":"1608227564671942289","title":"Vesicle trafficking and membrane dynamics","description":"Based on GO terms emphasizing endosome-to-plasma membrane transport, endosome-to-lysosome transport, lysosomal membrane organization, and synaptic vesicle budding, along with regulation of exocytosis, GTPase activity, and spine/polarity processes, the cluster appears to center on coordinated vesicle trafficking and membrane remodeling across epithelial and neuronal contexts. The recurring themes support a cohesive function in trafficking and membrane organization.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":3},{"id":"GO:1905751","count":3},{"id":"GO:0060999","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0030037","count":3}]},{"hash":"936486601241791500","title":"Growth factor\u2013driven MAPK/ERK signaling and cell migration","description":"This cluster centers on growth-factor\u2013triggered signaling that coordinates movement and morphogenesis. Its terms include cellular responses to transforming growth factor beta and platelet-derived growth factor, regulation of the ERK1/2 cascade and calcium-mediated signaling, positive regulation of STAT tyrosine phosphorylation, neutrophil chemotaxis, and cell\u2013cell signaling, as well as branching morphogenesis in mammary gland ducts. Together these indicate MAPK/ERK- and related pathway activity governing migration and development.","confidence":"High","size":7,"edges":9,"triangles":7,"max_degree":4,"top_function":"wound healing","top_go_terms":[{"id":"GO:0071560","count":7},{"id":"GO:0014911","count":7},{"id":"GO:0036120","count":7},{"id":"GO:0070374","count":7},{"id":"GO:0050850","count":7}]},{"hash":"819221991506538399","title":"Pollen exine formation and anther dehiscence","description":"The top GO terms show strong signals for pollen exine formation and anther dehiscence, indicating a role in male gametophyte development and pollen wall biosynthesis. Additional terms like protein N-linked glycosylation could pertain to secreted or wall-associated proteins needed for exine assembly, while nucleotide catabolic processes may reflect broader metabolic support during pollen development. Overall, the cluster appears to represent pollen development and exine biosynthesis.","confidence":"High","size":7,"edges":17,"triangles":19,"max_degree":6,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0046706","count":3},{"id":"GO:0046712","count":3},{"id":"GO:0006256","count":3},{"id":"GO:0046032","count":3},{"id":"GO:0009901","count":3}]},{"hash":"100697222770712353","title":"Mitochondrial tRNA aminoacylation and translation","description":"The top terms indicate translation and multiple tRNA aminoacylation reactions (prolyl, threonyl, seryl in mitochondria, glycyl and alanyl in mitochondria), plus regulation of translational fidelity and amino acid starvation responses. This points to a cohesive cluster centered on the tRNA charging machinery and the translation process, with a mitochondrial emphasis.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006450","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0006433","count":1},{"id":"GO:0006435","count":1},{"id":"GO:0070158","count":1}]},{"hash":"2266927476242444732","title":"Multi-substrate membrane transporters","description":"The top GO terms are dominated by various transmembrane transport activities for different substrates (nitrate, nitrite, phosphate, galactose, 4-hydroxyphenylacetate, xenobiotics) and even neurotransmitter loading, indicating a shared role in transporting diverse molecules across membranes. While there are a couple of unrelated terms like ribosome biogenesis and protein kinase activation, the strongest signal is membrane transport, suggesting this cluster represents a group of substrate transporters with broad specificity.","confidence":"Medium","size":7,"edges":15,"triangles":14,"max_degree":6,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0032147","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0015706","count":2},{"id":"GO:1900754","count":2},{"id":"GO:0035435","count":2}]},{"hash":"1422280999523376837","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":8,"triangles":2,"max_degree":6,"top_function":"cytoskeleton organization","top_go_terms":[{"id":"GO:0044205","count":3},{"id":"GO:0007411","count":3},{"id":"GO:0009442","count":3},{"id":"GO:0030516","count":3},{"id":"GO:0048678","count":3}]},{"hash":"1612437385518628898","title":"Cilia assembly and motility","description":"Based on the GO terms, there is a clear signal for ciliary structure and function: axoneme assembly, motile cilium assembly, and cilium movement involved in cell motility. Other terms in the cluster are heterogeneous and don\u2019t unify under a single clear theme, so the ciliogenesis/motility signal is the most coherent and representative. Confidence is Medium due to data noise and partial overlap with unrelated processes.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042771","count":1},{"id":"GO:0071222","count":1},{"id":"GO:0034051","count":1},{"id":"GO:0033209","count":1},{"id":"GO:0042347","count":1}]},{"hash":"2074707856761756688","title":"Skeletal muscle thin filament assembly and development","description":"The cluster is dominated by skeletal muscle\u2013related terms, especially thin filament assembly and muscle fiber development, indicating proteins likely participate in building and organizing the muscle cytoskeleton. Additional terms touch on cytoskeletal regulation and vesicle trafficking, which can accompany general cell organization but do not override the muscle-focused signal. Overall, the muscle-related terms best capture the main theme of the cluster.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001300","count":6},{"id":"GO:0030240","count":6},{"id":"GO:1904623","count":6},{"id":"GO:0048741","count":6},{"id":"GO:0030100","count":6}]},{"hash":"618435848024117846","title":"Steroid and lipid biosynthesis","description":"Top GO terms cluster around lipid and steroid production, including sphingolipids, very long-chain fatty acids, testosterone, glucocorticoids, and cofactor biosynthesis (tetrahydrobiopterin). Some terms like lung development and transcription regulation may reflect broader context, but the dominant signal is lipid/steroid biosynthetic activity.","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0006729","count":4},{"id":"GO:0061370","count":4},{"id":"GO:0006666","count":4}]},{"hash":"1131481173458707236","title":"Unknown","description":"The top terms span diverse processes (amino acid biosynthesis/metabolism, magnesium transport, retina development, photorespiration, and cell-cycle regulation) with no clear common function, suggesting no cohesive theme for a concise label.","confidence":"","size":7,"edges":9,"triangles":5,"max_degree":5,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0019343","count":3},{"id":"GO:0006535","count":3},{"id":"GO:1903830","count":3},{"id":"GO:0060041","count":3},{"id":"GO:0009853","count":3}]},{"hash":"391893403295372298","title":"Diverse metabolite biosynthesis","description":"The top terms are all biosynthetic processes for a range of compounds (antibiotics, flavonoids like kaempferol and anthocyanins, lipoteichoic acid, glycosylation precursors), suggesting a theme of diverse metabolite production rather than a single specific function. Hence, a label focusing on broad biosynthesis of metabolites fits best, though the diversity lowers confidence about a tighter specialization.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0017000","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0008360","count":3},{"id":"GO:0033330","count":3},{"id":"GO:0070395","count":3}]},{"hash":"938745849825346589","title":"Flavonoid Biosynthesis","description":"The top GO terms point to flavonoid pigment production, with clear emphasis on anthocyanin-containing compound biosynthesis, kaempferol O-glucoside biosynthesis, and cyanidin 3-O-glucoside biosynthesis, suggesting a flavonoid biosynthetic cluster. There are also related glycosylation-related processes that align with flavonoid glycosylation steps, supporting a theme of flavonoid biosynthesis and modification. Overall, the proteins likely participate in flavonoid biosynthesis pathways and their sugar additions.","confidence":"High","size":7,"edges":9,"triangles":5,"max_degree":4,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":5},{"id":"GO:0055114","count":3},{"id":"GO:0008360","count":3},{"id":"GO:0033330","count":3},{"id":"GO:0070395","count":3}]},{"hash":"2210590297523984118","title":"Unknown","description":"The GO terms span muscle fiber type transitions, angiogenesis, calcium signaling, neuronal development, chromosome/chromatin regulation, apoptosis, and immune receptor signaling, with no single unifying theme and no edges linking the proteins; the cluster appears functionally heterogeneous rather than cohesive.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014883","count":2},{"id":"GO:0014886","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0051481","count":2},{"id":"GO:0010976","count":2}]},{"hash":"2289019664061971623","title":"Neuronal migration, axon guidance, and synapse assembly","description":"Based on the GO terms, the cluster centers on neural development: interneuron migration, axon guidance, paranodal/juxtaparanodal organization, and synapse assembly with associated cell adhesion. A few terms about bone or immune processes appear as outliers, but the dominant theme is neural connectivity. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021836","count":3},{"id":"GO:0071205","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0030913","count":3},{"id":"GO:0007156","count":3}]},{"hash":"1968005945411752121","title":"Schwann cell development and PNS myelination","description":"The top GO terms include Schwann cell development and myelination in the peripheral nervous system, which strongly point to glial differentiation and myelination in the PNS. The epithelial-to-mesenchymal transition term also aligns with neural crest origins of Schwann cells, while other terms may reflect ancillary stress or regulatory processes during development. ","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0005981","count":7},{"id":"GO:1905205","count":7},{"id":"GO:2001034","count":7},{"id":"GO:0001837","count":7},{"id":"GO:0014044","count":7}]},{"hash":"2263227647004444774","title":"Immune-ECM Remodeling","description":"The top GO terms cluster around immune activity (T cell activation via TCR-MHC, complement activation, blood coagulation) and extracellular matrix remodeling (hyaluronan metabolism, metallopeptidase activity, cell-matrix adhesion, ECM assembly regulation). This suggests a functional theme of immune signaling coupled with remodeling of the extracellular matrix, despite some less related terms that may reflect broader annotation. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030212","count":3},{"id":"GO:0002291","count":3},{"id":"GO:1905050","count":2},{"id":"GO:0007161","count":2},{"id":"GO:0035987","count":2}]},{"hash":"1337932421452635259","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":2},{"id":"GO:0031047","count":1},{"id":"GO:0030263","count":1},{"id":"GO:0002107","count":1},{"id":"GO:0010832","count":1}]},{"hash":"1041848810400420930","title":"Developmental signaling and tissue remodeling","description":"The cluster contains GO terms spanning developmental processes (heart development, angiogenesis, ovulation, olfactory neuron migration) along with signaling and adhesion activities (MAPK regulation, cell-matrix adhesion, potassium channel clustering). This pattern suggests a broad theme of developmental signaling and tissue remodeling across multiple tissues rather than a single specific function.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032729","count":3},{"id":"GO:2001108","count":2},{"id":"GO:0007161","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0021836","count":2}]},{"hash":"2150644384495428029","title":"Endocytosis and Receptor Signaling","description":"The cluster shows a coherent theme around membrane trafficking and signaling: endocytosis, COPII vesicle budding, ruffle assembly, and engulfment of apoptotic cells point to vesicle trafficking and actin remodeling, while T cell receptor signaling, ephrin receptor signaling, and ERK cascade indicate receptor-mediated signaling pathways. Some terms are obsolete or peripheral (e.g., Wnt/PI3K references), but the core pattern supports a link between endocytic processes and surface signal transduction.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043552","count":4},{"id":"GO:0031532","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0048013","count":4},{"id":"GO:0090263","count":4}]},{"hash":"2266179484038868290","title":"ER tubular network organization and membrane biogenesis","description":"The terms cluster around endoplasmic reticulum morphology (tubular network formation/maintenance) and ER-associated organelle biogenesis (peroxisomes, nuclear pore complex) with steroid biosynthesis, plus several development-related processes (neuronal migration, axon guidance, EMT) suggesting ER roles in development. This points to a cohesive theme of ER structure and membrane-based organelle assembly driving development.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990809","count":2},{"id":"GO:0021801","count":2},{"id":"GO:0006694","count":2},{"id":"GO:0071787","count":2},{"id":"GO:0071788","count":2}]},{"hash":"609913682209483208","title":"Neurodevelopment and vesicle exocytosis","description":"This cluster is enriched for nervous system and brain development terms, suggesting roles in neural formation or maturation. The concurrent GO terms for vesicle fusion and calcium ion-dependent exocytosis point to secretory processes tied to neurotransmitter release, aligning a neurodevelopmental function with neuronal secretion. Some terms span broader multicellular development, but the combination of neural development with exocytosis supports a neurosecretory/neural-development theme.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0001302","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0006906","count":6},{"id":"GO:0043547","count":6}]},{"hash":"38790699979262556","title":"Calcium Homeostasis and Ion Transport","description":"Calcium handling is the dominant theme: transport into/out of cytosol and ER, ER Ca2+ concentration, and processes linked to muscle relaxation and membrane repolarization. Minor mentions of potassium and copper transport exist, but the core signal is Ca2+ homeostasis.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903515","count":2},{"id":"GO:0006874","count":2},{"id":"GO:0051208","count":2},{"id":"GO:0032470","count":2},{"id":"GO:1990573","count":2}]},{"hash":"814535311327880641","title":"Chromatin organization and nucleosome assembly","description":"The top GO terms cluster around chromatin biology: heterochromatin organization, nucleosome assembly, regulation of nucleus size, and protein localization to chromatin. Despite a few obsolete terms, the recurring themes are chromatin structure and histone-related processes, suggesting the proteins function together in organizing DNA into nucleosomes and localizing components to chromatin.","confidence":"High","size":7,"edges":16,"triangles":20,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0070828","count":6},{"id":"GO:0097298","count":6},{"id":"GO:0080182","count":6},{"id":"GO:0006334","count":6},{"id":"GO:0016584","count":6}]},{"hash":"809407293768652097","title":"Eye pigment granules and visual system components","description":"This cluster is driven by GO terms tied to eye pigment granule organization, retina homeostasis, and pigment-based coloration (eye and cuticle), all pointing to visual system biology in insects. Additional neuronal terms related to synaptic processes and dopamine uptake fit with vision-related neural signaling, supporting a theme around pigment and visual system components. Confidence is Medium.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001580","count":1},{"id":"GO:0001895","count":1},{"id":"GO:0070233","count":1},{"id":"GO:1900244","count":1},{"id":"GO:0051584","count":1}]},{"hash":"55277871793709590","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms are dominated by ubiquitination and proteolysis-related processes (autoubiquitination, ubiquitin-dependent protein catabolic process, K48-linked ubiquitination, ERAD), indicating the proteins in this cluster primarily function in tagging and degrading other proteins, i.e., protein turnover via the ubiquitin-proteasome system. Some terms about organ growth and dosage compensation appear, but the clear theme is ubiquitin-mediated degradation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0046621","count":3},{"id":"GO:0060816","count":3},{"id":"GO:0038018","count":3}]},{"hash":"1185141436787983303","title":"Translation initiation and regulation","description":"The dominant GO terms describe formation of the translation preinitiation complex, regulation of translational initiation, and translational initiation itself, indicating a core function in initiating protein synthesis. A few terms (e.g., centrosome cycle, DNA methylation-related processes) appear as minor, possibly incidental annotations. Overall, the cluster seems to group proteins involved in translation initiation and its control, including contexts related to viral translation. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":1},{"id":"GO:0006446","count":1},{"id":"GO:0075525","count":1},{"id":"GO:0006413","count":1},{"id":"GO:0045869","count":1}]},{"hash":"487676520864455869","title":"Hematopoiesis and immune cell proliferation","description":"This cluster shows hematopoietic/immune development signals, including larval lymph gland hemopoiesis, T cell and Th1 regulation, neutrophil apoptosis, and cell-cycle promotion, plus calcium signaling and membrane localization that support immune cell proliferation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070588","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0035167","count":1},{"id":"GO:0042102","count":1}]},{"hash":"998739690808052564","title":"Neural signaling and sensory processing","description":"The cluster is dominated by neural-related terms: negative regulation of synaptic transmission, regulation of pain perception, locomotory behavior, prepulse inhibition, and GPCR signaling modulation, suggesting a theme of neural signaling and sensory modulation. Some terms (electron transport chain, cell wall/macromolecule catabolic processes) appear unrelated and may reflect annotation noise.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022900","count":5},{"id":"GO:0051482","count":5},{"id":"GO:0016998","count":5},{"id":"GO:0051967","count":5},{"id":"GO:0009253","count":5}]},{"hash":"131393971858536631","title":"NF-kB\u2013driven inflammatory response to Gram-positive bacteria","description":"The highest GO terms cluster around canonical NF-kappaB signaling, TLR4 signaling, inflammatory response, cytokine production, and defense against Gram-positive bacteria, with regulation of IL-8 and JNK pathways. This points to an innate immune signaling module activated by Gram-positive bacterial components, driving cytokine production.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007249","count":2},{"id":"GO:0071223","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0002374","count":2}]},{"hash":"897585909623003590","title":"Developmental and stress-response regulators","description":"This cluster\u2019s GO terms cluster around organismal development (spinal cord, skin, retina) and cellular responses to stress signals (TGF-beta, cadmium, hypoxia), plus growth signaling (positive regulation of TORC1) and regulatory processes affecting the cytoskeleton (Arp2/3) and chromatin (histone modifications). Taken together, the proteins appear to act as regulators coordinating development with environmental and growth-related signals, rather than a single, cohesive pathway. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021510","count":7},{"id":"GO:0071560","count":7},{"id":"GO:0071276","count":7},{"id":"GO:1904263","count":7},{"id":"GO:0034316","count":7}]},{"hash":"413133465292732457","title":"ECM remodeling and immune activation","description":"The cluster is dominated by GO terms related to extracellular matrix (ECM) dynamics and cell-ECM interactions, including positive regulation of metallopeptidase activity, negative regulation of ECM assembly, hyaluronan metabolic process, and calcium-independent cell-matrix adhesion. Additional terms point to immune/vascular processes (blood coagulation, complement activation), which often intersect with ECM remodeling. Some plant-specific terms appear, but the core pattern across most terms supports a unified theme of ECM remodeling and adhesion. The lack of edges among proteins reduces direct connectivity, but the apparent functional theme is coherent.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905050","count":5},{"id":"GO:0007161","count":5},{"id":"GO:0035987","count":5},{"id":"GO:0048455","count":5},{"id":"GO:0030212","count":5}]},{"hash":"1412200237950388229","title":"Embryonic organogenesis","description":"This cluster's top GO terms cluster around embryonic development and morphogenesis across multiple organs (heart, retina, gonad, pancreas, digestive tract, pituitary) and include regulation of Wnt signaling. There isn't a single tissue-specific function, but a shared role in general organ formation and patterning, hence the label Embryonic organogenesis.","confidence":"Medium","size":7,"edges":13,"triangles":11,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0061296","count":7},{"id":"GO:0021937","count":7},{"id":"GO:0008585","count":7},{"id":"GO:2000288","count":7},{"id":"GO:0030111","count":7}]},{"hash":"37689667748693133","title":"Unknown","description":"Top terms in this cluster span metal-stress response, cytoskeletal dynamics, ubiquitination, circadian regulation, and various developmental processes, with only one edge connecting them. There isn\u2019t a single coherent functional theme that ties these proteins together, so a meaningful, specific label cannot be assigned. ","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":2},{"id":"GO:0046785","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0042752","count":2},{"id":"GO:0021678","count":2}]},{"hash":"997752572701853323","title":"Unknown","description":"These proteins show a mix of roles across signaling (GPCR internalization), ion channel organization, cell adhesion and developmental patterning, plus transcription and DNA repair activities. The terms do not converge on a single function or pathway, and there are no interactions among the members (Edges 0), so there isn't a clear, cohesive theme to name the cluster.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002031","count":4},{"id":"GO:0045162","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0060972","count":3}]},{"hash":"54488433021758703","title":"Metal Stress Response and Innate Immunity","description":"This cluster shows enrichment for cellular responses to metal stress (arsenite and cadmium) alongside innate immune defense terms (innate immune response, defense against Gram-positive bacteria). While other terms appear more generic or outdated, the strongest, overlapping themes are metal-induced stress responses and innate immune functions, suggesting the proteins may be involved in stress signaling linked to immune defense.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903936","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0002088","count":2},{"id":"GO:0006351","count":2},{"id":"GO:2001033","count":2}]},{"hash":"1229711640119124033","title":"Embryonic organ development and morphogenesis","description":"The top GO terms point to development and morphogenesis across multiple organs (heart, retina, gonad, pancreas, digestive tract, hypophysis) and include regulation of Wnt signaling, a central developmental pathway. This suggests a common theme of embryonic organ formation rather than a single specific function, justifying a general label for the cluster.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061296","count":7},{"id":"GO:0021937","count":7},{"id":"GO:0008585","count":7},{"id":"GO:2000288","count":7},{"id":"GO:0030111","count":7}]},{"hash":"718602045333692424","title":"Unknown","description":"Top terms are highly heterogeneous, spanning neural signaling, innate immunity, cytokine responses, hormone- and metal-stimulus responses, DNA replication, and cell-cycle processes, with no single dominant shared function. This lack of a cohesive theme suggests no clear cluster-specific function can be defined.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060079","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0097011","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0042535","count":3}]},{"hash":"697944774039727386","title":"Embryonic organogenesis and morphogenesis","description":"This cluster shows a broad enrichment for developmental and morphogenesis terms across multiple organs (heart, retina/eye, pituitary, digestive tract, gonad) and includes regulation of Wnt signaling, suggesting proteins involved in embryonic organ development and tissue morphogenesis rather than a single tissue-specific function. Confidence: Medium","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0061296","count":7},{"id":"GO:0021937","count":7},{"id":"GO:0008585","count":7},{"id":"GO:2000288","count":7},{"id":"GO:0048557","count":7}]},{"hash":"1135658199947274210","title":"Inflammation-driven angiogenesis and nerve development","description":"The cluster shows enrichment for inflammatory and angiogenic processes (inflammatory response, response to LPS, tube development, leukocyte tethering/rolling, endothelial sprouting regulation, cell-matrix adhesion) and also signals related to neural development (myelination in PNS, oligodendrocyte differentiation). This suggests proteins in the cluster participate in inflammation-associated vascular remodeling and may influence nerve development. ","confidence":"Medium","size":7,"edges":10,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0006954","count":4},{"id":"GO:0032496","count":4},{"id":"GO:0071260","count":4},{"id":"GO:1903588","count":4}]},{"hash":"477211453236265773","title":"Ubiquitin-Mediated Proteolysis","description":"The cluster is dominated by GO terms about ubiquitination (autoubiquitination, various K linkages) and ubiquitin-dependent protein catabolic processes, pointing to protein tagging for degradation. Additional terms touch peroxisome import and ERAD, but the central theme remains ubiquitin-driven protein turnover, with a potential regulatory role in NF-kappaB signaling and cell cycle. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051865","count":4},{"id":"GO:0070936","count":4},{"id":"GO:0085020","count":4},{"id":"GO:0070979","count":4},{"id":"GO:0042787","count":4}]},{"hash":"2240801387472655143","title":"Inflammatory signaling and tissue development","description":"The GO terms point to regulation of NF-kappaB signaling (an inflammatory pathway), together with processes related to cell proliferation and development across tissues (keratinocytes, hair follicles, smooth muscle, spleen) and immune/coagulation-related functions. Although the proteins are not connected in the network here, the functional themes converge on signaling-driven tissue remodeling and immune-associated development, justifying a label around inflammatory signaling intertwined with tissue development.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":4},{"id":"GO:0051260","count":3},{"id":"GO:0042381","count":2},{"id":"GO:0051482","count":2},{"id":"GO:0006517","count":2}]},{"hash":"1059219575005655566","title":"Oxidative Stress Response and Detoxification","description":"The predominant GO terms center on response to toxic substances, redox/oxidation-reduction processes, nitric oxide biosynthesis, and cellular oxidant detoxification, pointing to a core function in managing oxidative stress and detox pathways. Some terms (e.g., heart development, strigolactone biosynthesis) are more specific to other contexts and may be less reflective of the cluster\u2019s main theme, but the overall signal supports redox regulation and detox as the main thread.","confidence":"Medium","size":7,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":5},{"id":"GO:0055114","count":4},{"id":"GO:0045429","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0007507","count":2}]},{"hash":"791449902034154806","title":"Glycosaminoglycan Biosynthesis and ECM Morphogenesis","description":"The cluster is driven by GO terms for proteoglycan biosynthesis (keratan sulfate, heparan sulfate, chondroitin sulfate), pointing to glycosaminoglycan production and extracellular matrix composition. The embryonic neurocranium morphogenesis term supports a developmental/ECM role in craniofacial formation. While several other metabolic terms are broader, the strongest theme is GAG biosynthesis and ECM-associated morphogenesis.","confidence":"Medium","size":7,"edges":16,"triangles":15,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0018146","count":5},{"id":"GO:0015015","count":5},{"id":"GO:0048702","count":5},{"id":"GO:0009812","count":5},{"id":"GO:0006068","count":5}]},{"hash":"224884354102342440","title":"Dendritic spine morphogenesis and actin remodeling","description":"Dominant terms include dendritic spine morphogenesis and actin crosslink formation, pointing to cytoskeletal remodeling during neuronal development; accompanying terms such as NGF/TGF-\u03b2 signaling and cell migration suggest broader developmental signaling accompanying morphogenesis.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0009395","count":4},{"id":"GO:0060997","count":4},{"id":"GO:0035156","count":3},{"id":"GO:0014911","count":3},{"id":"GO:0061847","count":3}]},{"hash":"1761597049277638504","title":"Transmembrane Transport of Nutrients and Xenobiotics","description":"The top GO terms cluster around moving various substrates across membranes\u2014vitamins, amino acids, taurine, and xenobiotics (including daunorubicin) with xenobiotic export and related transport processes\u2014indicating a cohesive role in transmembrane substrate transport; a keratinization term appears as a minor outlier but does not define the cluster\u2019s main function.","confidence":"High","size":7,"edges":8,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0003333","count":1},{"id":"GO:0043215","count":1}]},{"hash":"1955662101639781456","title":"Neural development and synaptic signaling","description":"Based on the top GO terms, the proteins cluster around neural development and synaptic processes: axon guidance, neural tube closure, dendrite morphogenesis, synapse assembly, and neurotransmission-related terms. A few terms (mRNA stabilization, mitotic cell cycle, T cell regulation) are less central, but the overall theme is neuronal differentiation and synaptic function.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0048255","count":3},{"id":"GO:0000278","count":2},{"id":"GO:0007411","count":1},{"id":"GO:0042130","count":1},{"id":"GO:0001843","count":1}]},{"hash":"48108406077556617","title":"Unknown","description":"These six proteins are annotated with a mix of terms spanning subtelomeric heterochromatin formation, several immune signaling pathways (T cell receptor signaling, non-canonical NF-kappaB, C-type lectin receptor signaling), Wnt signaling, RNA modification (tRNA and rRNA pseudouridylation), and proteolysis regulation. There is no single coherent function or pathway that clearly unifies these terms, making a meaningful, specific cluster label not possible. ","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":3},{"id":"GO:0090263","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0000455","count":1},{"id":"GO:0031119","count":1}]},{"hash":"140542237040431862","title":"Nuclear Regulation and Telomere Maintenance","description":"This cluster is driven by GO terms about regulating telomere maintenance (via telomerase) and telomere capping, alongside regulation of nuclear processes such as transcription by RNA Pol II, and nuclear import and cell-cycle control. Although a few terms touch mitochondria and signaling, the dominant theme appears to be nuclear regulation and genome stability, with telomere-associated regulation as a central thread.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":1},{"id":"GO:0051973","count":1},{"id":"GO:0042308","count":1},{"id":"GO:0000122","count":1},{"id":"GO:1904355","count":1}]},{"hash":"1073165639090262565","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042619","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0017000","count":3},{"id":"GO:0008611","count":2},{"id":"GO:0009244","count":2}]},{"hash":"572032248195876324","title":"Energy metabolism and phosphorylation signaling","description":"The dominant GO terms point to metabolic catabolism and energy production, including fatty acid beta-oxidation, leucine and carnitine metabolism, and starvation/cold responses, complemented by phosphorylation/dephosphorylation as a regulatory layer. While a few terms are peripheral (e.g., ascaroside biosynthesis, heart development), the core theme is metabolism plus signaling regulation, supporting this cluster name.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":3},{"id":"GO:0016311","count":3},{"id":"GO:1904070","count":2},{"id":"GO:0033539","count":2},{"id":"GO:0007507","count":2}]},{"hash":"741145729978296865","title":"Epidermal development and cell cycle regulation","description":"GO terms point to skin development and control of epidermal cell division, notably regulation of CDK activity. This suggests the cluster centers on epidermal proliferation and differentiation with cell-cycle control. Also elements of apoptosis signaling (cytochrome c release) and insulin response indicate stress/metabolic links that can intersect epidermal biology. A Golgi localization term is present but secondary; overall theme remains epidermal growth and division with cell-cycle regulation.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051683","count":5},{"id":"GO:0010482","count":5},{"id":"GO:1900740","count":5},{"id":"GO:0043588","count":5},{"id":"GO:0000079","count":5}]},{"hash":"365847748605235545","title":"Podosome formation and actin remodeling","description":"The cluster weights heavily toward actin cytoskeleton dynamics: podosome formation, Arp2/3-mediated nucleation regulation, leading-edge localization, and general actin filament remodeling, all pointing to actin-based cell migration/morphology. While a few terms touch other contexts (neuronal projection, immune defense), the core theme is actin-driven structural remodeling. ","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2000249","count":2},{"id":"GO:0050832","count":1},{"id":"GO:0045862","count":1},{"id":"GO:0045792","count":1},{"id":"GO:1905873","count":1}]},{"hash":"815516343532724976","title":"Ubiquitin-mediated protein degradation","description":"Most of the top GO terms center on ubiquitination and proteasomal pathways (K48-linked ubiquitination, ubiquitin-dependent protein catabolic process, autoubiquitination, ERAD). Additional terms reference turnover/quality control (Wnt receptor catabolic process) and cargo handling (peroxisomal matrix protein import), which can link to regulated degradation and turnover. Overall, the cluster appears to reflect proteins involved in tagging and directing proteins for degradation rather than a single specific organ function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046621","count":2},{"id":"GO:1902187","count":2},{"id":"GO:0060816","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0038018","count":2}]},{"hash":"2042074626133661306","title":"ERAD and heat-stress proteostasis","description":"The cluster is enriched for ubiquitin-dependent ERAD, misfolded protein transport, and responses to heat and unfolded proteins (e.g., unfolded protein response, heat response), indicating a cohesive theme of protein quality control and proteostasis under heat stress. Some non-proteostasis terms (like DNA replication) may be noise, but the dominant signals support ERAD- and heat-stress\u2013related function.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:0006260","count":4},{"id":"GO:0006469","count":3},{"id":"GO:0032781","count":3},{"id":"GO:1900035","count":3}]},{"hash":"212187936181607050","title":"Nucleotide Salvage and Catabolism","description":"Based on GO terms dominated by purine/pyrimidine nucleobase metabolism and salvage (guanosine, inosine, uridine, nicotinate nucleotide salvage) and interconversion of nucleobase-containing small molecules, the proteins in this cluster likely participate in nucleotide salvage and catabolic pathways. The nitric oxide response term appears incidental and does not define the cluster\u2019s main function. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015949","count":1},{"id":"GO:0006152","count":1},{"id":"GO:0006216","count":1},{"id":"GO:0006206","count":1},{"id":"GO:0006179","count":1}]},{"hash":"345131438600848380","title":"Unknown","description":"The top GO terms are highly heterogeneous, spanning olfactory nerve structure, chromatin-related regulation (histone methylation), nuclear protein localization, cell motility, cardiac proliferation, stem cell maintenance, viral transmission, dolichyl phosphate biosynthesis, autoubiquitination, and neuronal apoptosis. This mix does not converge on a single coherent biological function or pathway, making it unclear how these proteins function as a unified cluster. Therefore, an Unknown label is appropriate.","confidence":"","size":6,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021629","count":3},{"id":"GO:1905437","count":3},{"id":"GO:1900180","count":3},{"id":"GO:2000146","count":3},{"id":"GO:0060044","count":3}]},{"hash":"895072163329261125","title":"Proteasome-regulated immune and antiviral responses","description":"The cluster's GO terms cluster around ubiquitin-proteasome\u2013dependent protein degradation (SCF-dependent proteasomal ubiquitin-mediated catabolism) and immune/antiviral processes (defense response to virus, regulation of IL-17 signaling, chemokine production), along with spleen development and growth regulation. This suggests a cohesive theme where protein turnover via the proteasome modulates immune and antiviral signaling pathways.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048536","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0031146","count":2},{"id":"GO:0046621","count":2},{"id":"GO:1903886","count":2}]},{"hash":"787692125523527024","title":"Immune signaling and apoptosis regulation","description":"The top GO terms reveal a theme of immune signaling and regulation of cell death, including canonical NF-kappaB activation, interleukin-8 production, protection from NK cell-mediated cytotoxicity, and modulation of extrinsic apoptotic pathways. While a couple of terms are broader (mechanical stimulus, nutrient response), the majority point to immune communication and apoptosis control, suggesting these proteins function in immune signaling networks and death receptor pathways. Overall, the cluster seems to capture a coherent immune-apoptosis module, with a few peripheral terms. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":4},{"id":"GO:0043123","count":3},{"id":"GO:0042628","count":3},{"id":"GO:2001238","count":3},{"id":"GO:0007584","count":3}]},{"hash":"1288932798920035605","title":"Virus infection and replication","description":"The top GO terms include virion assembly, establishment of proviral latency, and symbiont entry into host, which together point to viral life-cycle processes; other terms such as RNA-templated DNA biosynthetic process and protein isomerization may reflect related host interactions or general protein processing, but the dominant signal is viral infection/replication, despite some unrelated terms like sepal formation that look like noise.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":"protein folding","top_go_terms":[{"id":"GO:0071492","count":3},{"id":"GO:0050714","count":3},{"id":"GO:0048453","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0000413","count":3}]},{"hash":"1500538749009400247","title":"Developmental morphogenesis and actin dynamics","description":"The cluster centers on morphogenesis and developmental signaling, with GO terms like neural tube closure, histoblast morphogenesis, and larval CNS remodeling, plus actin-related processes such as positive regulation of actin polymerization and ruffle/bundle formation, suggesting coordinated cytoskeletal remodeling during development. The presence of smoothened signaling aligns with Hedgehog pathway roles in development. A few terms (innate immune response, viral transcription) appear as noise or broader signaling cross-talk, but the core theme is development-linked morphogenesis coupled with actin dynamics.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001843","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0007224","count":2},{"id":"GO:0007488","count":1},{"id":"GO:1900028","count":1}]},{"hash":"474496444008913298","title":"Regulation of muscle and nerve regeneration","description":"This cluster\u2019s GO terms cluster around skeletal muscle tissue regeneration, axon regeneration, collateral sprouting, and developmental regulation of the nervous system, suggesting a cohesive theme of controlling regeneration and development in muscle and neural tissues. Some terms touch on signaling and stress responses, but the predominant pattern is regulatory control of muscle and nerve tissue regeneration and development.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048671","count":2},{"id":"GO:0043403","count":2},{"id":"GO:2001108","count":1},{"id":"GO:0010482","count":1},{"id":"GO:0048681","count":1}]},{"hash":"1498472292840676704","title":"Multi-lineage differentiation","description":"These proteins map to GO terms across granulocyte and myeloid dendritic cell differentiation, peripheral nervous system neuron development, glial cell proliferation, and general cell fate commitment, suggesting a role in differentiation programs across multiple lineages rather than a single pathway. Some terms like PML body organization, NMJ acetylcholine-gated channel clustering, and BMP signaling may reflect ancillary or broader regulatory annotations.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071340","count":3},{"id":"GO:0060803","count":3},{"id":"GO:0030578","count":3},{"id":"GO:0030851","count":3},{"id":"GO:0043011","count":3}]},{"hash":"302826373562569371","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":3},{"id":"GO:0046597","count":3},{"id":"GO:0001778","count":3},{"id":"GO:0046598","count":3},{"id":"GO:0061158","count":3}]},{"hash":"1898751560484886455","title":"Radial glial scaffolding and neural development","description":"This cluster\u2019s top GO terms cluster around neural development, especially radial glial cells: forebrain radial glial differentiation, formation of radial glial scaffolds, and nervous system development. Supporting signals include Hedgehog (Smoothened) pathway and ERK cascade, plus cytoskeletal dynamics (filopodium assembly) and vesicle docking relevant to neural growth and synaptic/exocytotic processes. Some terms like spermatid development and mitochondrial inheritance appear tangential, but the dominant pattern points to radial glia-driven neural development.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051489","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0007286","count":5},{"id":"GO:0000001","count":5}]},{"hash":"1204605234361435837","title":"Glycosaminoglycan Proteoglycan Biosynthesis","description":"The cluster's top terms are dominated by glycosaminoglycan/proteoglycan biosynthesis (keratan sulfate, heparan sulfate, chondroitin sulfate), pointing to extracellular matrix production. Embryonic neurocranium morphogenesis aligns with ECM remodeling in development, supporting this proteoglycan/ECM-focused theme; other metabolic terms seem secondary.  ","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0018146","count":3},{"id":"GO:0015015","count":3},{"id":"GO:0048702","count":3},{"id":"GO:0009812","count":3},{"id":"GO:0006068","count":3}]},{"hash":"1941149025983876615","title":"Nuclear transport and mitotic chromosome alignment","description":"The cluster centers on nuclear import and chromosomal segregation processes: ribosomal protein import, snRNP import, transcription factor import, nuclear pore complex assembly, kinetochore localization, and mitotic metaphase chromosome alignment, indicating a shared theme of nuclear transport and mitosis. Some terms are older/obsolete or peripheral (desumoylation, phosphatidylcholine biosynthesis), which may reflect annotation noise but do not obscure the core pattern.","confidence":"Medium","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0034501","count":3},{"id":"GO:0060188","count":3},{"id":"GO:0006656","count":3},{"id":"GO:0045465","count":3},{"id":"GO:0051292","count":3}]},{"hash":"1989618229823081610","title":"Mitotic spindle orientation and cell cycle regulation","description":"The strongest signals are mitosis-related: establishment of mitotic spindle orientation and mitotic cell cycle, along with supportive terms like GTPase activity regulation and TORC1 signaling, pointing to cell-cycle control and mitotic mechanics. A few terms (spinal cord development, cadmium response) seem less connected, suggesting broader regulatory roles or annotation noise.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000132","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0070208","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1217298760474431585","title":"Unknown","description":"This cluster includes GO terms for organellar RNA processing and ribosome assembly (mitochondria and chloroplast), along with nuclear processes such as DNA strand elongation, chromatin formation, transcription regulation, embryonic cleavage, and circadian gene expression. The broad and diverse mix of functions provides no single, cohesive theme to bind the proteins, so a specific, representative label is not supported.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007076","count":2},{"id":"GO:1901259","count":1},{"id":"GO:0045333","count":1},{"id":"GO:0000963","count":1},{"id":"GO:1902775","count":1}]},{"hash":"1297334747358227280","title":"Gamete signaling and ion transport","description":"This cluster centers on GO terms related to reproductive signaling, including sperm capacitation, pheromone-dependent signaling for cellular conjugation, and prostaglandin response, suggesting roles in gamete communication. It also includes membrane transport processes like potassium ion import/export and fructose transmembrane transport, and regulation of Golgi to plasma membrane protein trafficking, indicating concurrent membrane transport/regulation. While some terms like sensory perception are less connected, the core theme points to reproductive signaling coupled with membrane transport functions.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048240","count":2},{"id":"GO:1990573","count":2},{"id":"GO:0097623","count":2},{"id":"GO:0042997","count":2},{"id":"GO:0007275","count":2}]},{"hash":"1503630590168077054","title":"Unknown","description":"The top GO terms span multiple, largely unrelated processes: centrosome cycle and mitotic centrosome separation (cell division), nervous system development and CNS neuron development (neurodevelopment), cellular response to glucose stimulus and cytosine metabolic process (metabolic/signal responses), caveolin-mediated endocytosis (membrane trafficking), mammary gland epithelial cell proliferation (tissue development), and regulation of JUN kinase activity (MAPK signaling). This lack of a cohesive functional theme suggests there isn\u2019t a single shared function tying the cluster together, so an Unknown label with None is appropriate.","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007100","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0071333","count":3},{"id":"GO:0072584","count":2},{"id":"GO:0033598","count":2}]},{"hash":"1668323756021762864","title":"MAPK-driven neural development and synaptic signaling","description":"The top terms cluster around nervous system development, hippocampus development, excitatory postsynaptic potential, ephrin receptor signaling, and positive regulation of ERK and JNK cascades, indicating a shared MAPK-regulated signaling theme in neural development and synaptic activity. While there are immune-related terms (T cell receptor signaling, beta selection), the dominant pattern is neural development and synaptic signaling, suggesting the cluster mainly reflects MAPK-mediated neural functions with some cross-talk. ","confidence":"Medium","size":6,"edges":8,"triangles":4,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0043552","count":5},{"id":"GO:0060079","count":5},{"id":"GO:0070374","count":5}]},{"hash":"1269309874223349285","title":"Unknown","description":"The terms mix innate immune activation (eosinophil degranulation, neutrophil killing, dendritic cell chemotaxis, LPS response) with diverse organ development processes (lung connective tissue, retina, heart, endothelial barrier). There isn\u2019t a single coherent function or pathway uniting all terms, so a specific, representative label isn\u2019t clearly supportable.","confidence":"","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043311","count":6},{"id":"GO:0060427","count":6},{"id":"GO:0070963","count":6},{"id":"GO:0051482","count":6},{"id":"GO:0060041","count":6}]},{"hash":"151096385333156954","title":"AGP Glycosylation and Plant Cell-Wall Glycans","description":"The top GO terms cluster around arabinogalactan proteins (AGPs), hydroxyproline-linked O-glycosylation, and various glycan biosynthesis processes (AGP metabolism, poly-N-acetyllactosamine, mucilage, etc.), pointing to post-translational modification of plant cell-wall glycoproteins and the biosynthesis of plant cell-wall glycans. Some insect-related terms appear but the dominant theme is AGP glycosylation and glycan construction in plant tissues.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042248","count":3},{"id":"GO:0018258","count":3},{"id":"GO:0075015","count":3},{"id":"GO:0007299","count":3},{"id":"GO:0080147","count":3}]},{"hash":"827322784308592674","title":"Neurodevelopment and Morphogenesis","description":"The cluster\u2019s top GO terms cluster around developmental and morphogenetic processes, especially dendrite morphogenesis, embryonic cranial skeleton morphogenesis, and multicellular organism development. Neural-related terms like sensory perception of pain further support a nervous system developmental theme, while transcription and DNA replication terms hint at proliferative states typical of developing tissues. Overall, the pattern points to neurodevelopmental and morphogenetic functions, though some terms are broad housekeeping processes. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043552","count":4},{"id":"GO:0001666","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0006351","count":4}]},{"hash":"1352436754332759663","title":"GTPase-driven cell polarity and endocytosis","description":"The top GO terms cluster around establishing epithelial cell polarity and regulating cell shape, with strong signals for small GTPase signaling and endocytosis, suggesting a module where Rab/Rho-family GTPases coordinate membrane trafficking with polarity cues. While some terms touch broader signaling contexts (T cell receptor signaling, neurotransmitter receptor transport), the core theme of GTPase-regulated polarity and endocytic trafficking best explains the cluster. ","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043552","count":6},{"id":"GO:0090162","count":6},{"id":"GO:0071963","count":6},{"id":"GO:0050852","count":6},{"id":"GO:0006897","count":6}]},{"hash":"1405806648544017185","title":"Developmental Differentiation and Hormone Signaling","description":"The items in this cluster consistently reference differentiation and developmental processes across multiple tissues (airway epithelium, heart, nervous system) and include regulation of hormone production or thyroid hormone generation. This points to a general theme of developmental differentiation intertwined with endocrine signaling, rather than a single specific pathway.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060486","count":5},{"id":"GO:0032912","count":5},{"id":"GO:0048485","count":5},{"id":"GO:0071353","count":5},{"id":"GO:0003290","count":5}]},{"hash":"468004958392900295","title":"PNS Axonogenesis and Glial Differentiation","description":"This cluster centers on nervous system development and maintenance, with multiple terms pointing to peripheral nervous system axonogenesis, axon diameter regulation, neurofilament assembly, and Schwann cell proliferation, plus glial differentiation signals. Also includes microtubule polarity, aligning with axon growth and cytoskeletal organization. An outlier term on complement activation is present but does not dominate the theme.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0060020","count":5},{"id":"GO:0030951","count":5},{"id":"GO:0090343","count":5},{"id":"GO:0010625","count":5}]},{"hash":"2280016874310219414","title":"Immune signaling and cytoskeletal dynamics","description":"The top terms point to immune processes (Th1-type response, interferon production) and endocytosis, with signaling (JNK cascade) and stress responses (xenobiotic, mechanical stimuli), plus cytoskeletal activities (tubulin assembly, spindle orientation). This suggests a cohesive module linking immune signaling with cytoskeletal remodeling and trafficking.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042088","count":3},{"id":"GO:0006897","count":3},{"id":"GO:0032729","count":3},{"id":"GO:0034260","count":3},{"id":"GO:0046330","count":3}]},{"hash":"1164489618703311357","title":"Neural memory and synaptic plasticity","description":"The top GO terms are dominated by brain-related functions: memory, astrocyte activation, hypoxia response in neural contexts, regulation of neuronal synaptic plasticity, and long-term potentiation, with references to substantia nigra development. This points to a shared theme of neural signaling and plasticity rather than structural or metabolic pathways, making the name representative of the cluster\u2019s likely function. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007613","count":3},{"id":"GO:0048143","count":2},{"id":"GO:0071456","count":2},{"id":"GO:2001015","count":2},{"id":"GO:0001837","count":2}]},{"hash":"1924793807002083795","title":"Calcium-Driven Developmental Signaling","description":"The cluster maps to processes where calcium acts as a central regulator across tissues: vesicle trafficking and endocytosis in neurons, insulin-containing secretory pathways, calcium-modulated signaling in Wnt pathways, and calcium-dependent regulation of cardiac contraction, heart rate, actin remodeling, and glial/retinal development. The repeated emphasis on calcium release, calcium-modulated signaling, and calcium-dependent cellular processes suggests a cohesive theme of calcium-driven development and signaling across neural, cardiac, and endocrine contexts.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":2},{"id":"GO:0010842","count":2},{"id":"GO:0030070","count":2},{"id":"GO:0010881","count":1},{"id":"GO:0002027","count":1}]},{"hash":"1794441762640278432","title":"Calcium-regulated neural signaling and endocytosis","description":"The top terms cluster around calcium-dependent processes impacting neural functions (synaptic vesicle endocytosis, retina development, astrocyte activation, amphetamine response, heart rate regulation via calcium, and calcium-modulated signaling pathways), plus regulation of endocytosis and cytoskeletal remodeling. This suggests a common theme of calcium-mediated signaling in neural and related tissues, including synaptic/endocytic regulation and development.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":3},{"id":"GO:0010842","count":3},{"id":"GO:0010881","count":2},{"id":"GO:0001975","count":2},{"id":"GO:0002027","count":2}]},{"hash":"871864960244703262","title":"Transcriptional Regulation and Apoptosis","description":"The dominant signals are DNA-templated transcription and regulation of transcription by RNA polymerase II, with explicit mention of apoptotic processes. This points to proteins involved in gene expression control that can influence cell fate decisions. While there are also terms referring to vesicle transport, nuclear pore assembly, and cytoskeletal organization, the strongest theme across the cluster is transcriptional regulation together with apoptotic signaling, suggesting a cohesive but broad regulatory role rather than a single, narrow function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0045944","count":2}]},{"hash":"62378955997730038","title":"Isoprenoid and sterol biosynthesis with growth signaling","description":"Based on the GO terms, the cluster centers on lipid/isoprenoid biosynthesis (carotenoid, carotene, ergosterol, farnesyl diphosphate) and also includes terms related to growth signaling pathways (TOR, ERK, PI3K/AKT). The mix suggests proteins involved in lipid metabolism with modulation of cell growth signaling, though some immune-regulatory terms may reflect broad annotations. The lack of edges makes the interpretation cautious, but the lipid biosynthesis theme is the strongest signal.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016117","count":1},{"id":"GO:0006696","count":1},{"id":"GO:0016120","count":1},{"id":"GO:0045338","count":1},{"id":"GO:0032007","count":1}]},{"hash":"1521348882675990600","title":"Cell cycle control and stress responses","description":"This cluster centers on regulation of mitotic cell cycle and centrosome maintenance, alongside cellular responses to environmental stresses (UV-A, cadmium, virus). Taken together, these terms point to a theme of coordinating cell division with stress signaling, despite some noise from plant-specific or obsolete terms.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007346","count":3},{"id":"GO:0071492","count":3},{"id":"GO:2000531","count":3},{"id":"GO:0051661","count":3},{"id":"GO:0071276","count":3}]},{"hash":"543968018372539825","title":"Embryonic and sensory organ development","description":"The GO terms are centered on development across multiple organs and systems (inner ear, forebrain, visual perception, forelimb morphogenesis, uterus and gonads, myoblast proliferation), indicating a broad embryonic organogenesis/sensory-neural development theme rather than a single tissue-specific function. Some terms are noisy (obsolete term, plant hormone regulation), but the overall pattern points to developmental processes. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0048839","count":5},{"id":"GO:0035115","count":5},{"id":"GO:0060065","count":5},{"id":"GO:0021846","count":5},{"id":"GO:0007601","count":5}]},{"hash":"1749300051451616082","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0032912","count":2},{"id":"GO:0060989","count":2},{"id":"GO:0036515","count":2},{"id":"GO:0002315","count":2}]},{"hash":"2173819110915373597","title":"Pol II Transcriptional Repression and Cell Cycle Regulation","description":"The top GO terms center on negative regulation of transcription by RNA polymerase II, along with related transcriptional and chromatin-associated processes (DNA-templated transcription elongation, antisense transcription, heterochromatin-related regulation) and cell cycle control, plus negative regulation of apoptosis. Although some terms are obsolete, the shared theme points to transcriptional repression with chromatin context and coordination of the cell cycle. Therefore, this label captures the core function of the cluster.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006354","count":2},{"id":"GO:0034773","count":2},{"id":"GO:0060195","count":2},{"id":"GO:0080182","count":2},{"id":"GO:0043066","count":2}]},{"hash":"1489754568631979041","title":"NF-kappaB\u2013driven immune regulation","description":"The cluster is anchored by NF-kappaB\u2013related terms (activation of NF-kappaB-inducing kinase, positive regulation of NF-kappaB transcription factor activity) and immune functions (positive regulation of immunoglobulin production and isotype switching to IgA), with dexamethasone response indicating broader immune modulation. Apoptosis-related terms (cytochrome c release, extrinsic apoptotic signaling) fit within NF-kappaB\u2013related survival pathways, while a couple of unrelated terms appear as noise; overall the immune/NF-kappaB theme is the strongest signal.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0048298","count":3},{"id":"GO:0051023","count":2},{"id":"GO:0007250","count":2},{"id":"GO:2001238","count":2}]},{"hash":"221059223949031294","title":"SCF-ubiquitin proteolysis and cell cycle regulation","description":"This cluster centers on ubiquitin-mediated degradation (polyubiquitination, SCF-dependent proteasomal degradation) and cell-cycle controls (negative regulation of G0 to G1, G1 DNA damage checkpoint, and proliferation). The co-occurrence of ubiquitination and cell-cycle\u2013related GO terms suggests proteins involved in targeted proteolysis that shapes cell-cycle progression, with some stress-related cadmium response signals included. Overall, the dominant theme is regulatory proteolysis linked to cell-cycle control.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":3},{"id":"GO:0000209","count":2},{"id":"GO:0070317","count":2},{"id":"GO:0051436","count":2},{"id":"GO:0008285","count":2}]},{"hash":"394774750765829854","title":"Transmembrane transport of amino acids and small molecules","description":"The cluster centers on transport across membranes for diverse substrates, including amino acids, taurine, vitamins, xenobiotics, daunorubicin, and trafficking between cytosol and ER, plus related export and regulatory activities. This points to a general transmembrane transport function rather than a specific cargo, justifying a concise label that captures small-molecule and amino-acid transport.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0003333","count":6},{"id":"GO:1902943","count":6},{"id":"GO:0043215","count":6},{"id":"GO:0051454","count":6},{"id":"GO:0046967","count":6}]},{"hash":"1839757199101171","title":"Cardiovascular and endothelial signaling","description":"This cluster\u2019s top GO terms cluster around cardiovascular biology: heart development, regulation of blood pressure, and modulation of endothelial barrier function, pointing to heart/vessel development and vascular regulation. The GPCR-mediated adenylate cyclase pathway also aligns with common signaling mechanisms controlling vascular tone and cardiac activity. Some terms reference other organs (lung/retina), but the strongest, most coherent signal is cardiovascular/endothelial signaling. ","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":6},{"id":"GO:0022900","count":6},{"id":"GO:0010579","count":6},{"id":"GO:0043311","count":5},{"id":"GO:0060427","count":5}]},{"hash":"2013714702961965612","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048026","count":1},{"id":"GO:0031047","count":1},{"id":"GO:0008315","count":1},{"id":"GO:1905612","count":1},{"id":"GO:0000184","count":1}]},{"hash":"1862529937782289874","title":"Mitochondrial dynamics and mitophagy","description":"The Top Terms show strong enrichment for mitochondrial processes: intracellular distribution of mitochondria, type 2 mitophagy, mitochondrial membrane fission, and regulation of cytochrome c release. These together point to a cluster centered on mitochondrial morphology and turnover. Other terms like ribosomal biogenesis or Golgi retention are peripheral, but the core theme is mitochondria quality control and signaling.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0048312","count":3},{"id":"GO:0001300","count":2},{"id":"GO:0061734","count":2},{"id":"GO:1903423","count":2}]},{"hash":"1481428500006535661","title":"Adaptive immune signaling and germinal center formation","description":"This cluster is dominated by adaptive immune terms: type 2 immune response, B cell receptor signaling, germinal center formation, and memory T cell differentiation, indicating a cohesive lymphoid/immune signaling theme. A few outlier terms exist (e.g., renal sodium absorption, muscle development), but the primary signal is adaptive immunity.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900477","count":3},{"id":"GO:0045497","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0002467","count":3},{"id":"GO:0042092","count":3}]},{"hash":"1747267841630183599","title":"Unknown","description":"The GO terms span oxidative stress response, nitrogen fixation, post-translational modification, and multiple organ development terms; there is no single cohesive function tying all six proteins together, making a precise label unreliable.","confidence":"","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071451","count":2},{"id":"GO:0009399","count":2},{"id":"GO:0051725","count":2},{"id":"GO:0048738","count":1},{"id":"GO:0009954","count":1}]},{"hash":"465217194625653790","title":"Actin cytoskeleton and cell adhesion in neural development","description":"The top GO terms emphasize actin-based processes (actin filament movement, crosslinking) and cell-matrix adhesion, suggesting cytoskeletal dynamics and adhesion as the core theme. Several neural-related terms (neuromuscular posture, cerebellar signaling, olfactory nerve organization) indicate involvement in neural structure and function, supporting a neural-development context. Some terms are broader or peripheral (centrosome maintenance, gonad development), but they do not override the dominant actin/adhesion and neural-development pattern.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":2},{"id":"GO:0050884","count":2},{"id":"GO:0045668","count":2},{"id":"GO:0021629","count":1},{"id":"GO:0051661","count":1}]},{"hash":"1019792476111164252","title":"Unknown","description":"The GO terms are highly varied, including ER retention and unfolded protein response, protein transport, innate immune signaling, and even development-related processes, with no single cohesive function tying all six proteins together.","confidence":"","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006621","count":1},{"id":"GO:0002369","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0010204","count":1},{"id":"GO:0070231","count":1}]},{"hash":"2132183408895031945","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046580","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0097309","count":1},{"id":"GO:2000288","count":1},{"id":"GO:0000494","count":1}]},{"hash":"1917339743685994215","title":"Nuclear RNA Processing and p53-Mediated Apoptosis","description":"These proteins show a clear emphasis on nuclear RNA metabolism and processing (deadenylation-independent decay, adenosine catabolism, exonucleolytic RNA hydrolysis, splicing, transcription), with a notable presence of the p53-mediated intrinsic apoptotic signaling term and general apoptotic processes. This suggests a theme where RNA processing functions intersect with stress-induced apoptosis pathways, even though other terms hint at broader cellular stress responses. Confidence: Medium","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031086","count":2},{"id":"GO:0006154","count":2},{"id":"GO:0090503","count":2},{"id":"GO:0072332","count":2},{"id":"GO:0036245","count":2}]},{"hash":"1425265150525165359","title":"Steroid hormone and lipid biosynthesis","description":"The top GO terms cluster around biosynthetic pathways for steroids (testosterone, glucocorticoids) and various lipids (sphingolipids, very long-chain fatty acids, poly-hydroxybutyrate, etc.), indicating a cohesive theme of lipid- and hormone-producing biosynthetic processes, even though a couple terms (lung development, transcription regulation) are less directly related.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0006729","count":4},{"id":"GO:0061370","count":4},{"id":"GO:0006666","count":4}]},{"hash":"1023390438422163714","title":"Spliceosome-driven mRNA processing and export","description":"This cluster is dominated by GO terms about spliceosome-mediated mRNA splicing, mRNA export from the nucleus, and regulation of mRNA stability and processing. The common theme is nuclear mRNA maturation and quality control, including splice site recognition and ncRNA-mediated regulation, which together point to a cohesive module of mRNA processing and export.","confidence":"High","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":5},{"id":"GO:0031047","count":5},{"id":"GO:0010610","count":5},{"id":"GO:0048255","count":5},{"id":"GO:0006376","count":5}]},{"hash":"2091388302723181628","title":"Metanephric kidney development","description":"The dominant GO terms are about metanephric kidney formation, including proximal/distal tubule development and mesonephric duct development, which strongly suggests a nephrogenesis-related cluster. While there are some immune signaling terms present, the Nephrogenesis theme best explains the cluster\u2019s functional annotation. ","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072237","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0050901","count":2},{"id":"GO:0010572","count":2},{"id":"GO:0038094","count":2}]},{"hash":"1476045523320669948","title":"Membrane trafficking and remodeling","description":"The terms cluster around vesicle transport, endocytic recycling, ER-vacuole interactions, autophagy-related membrane processes, membrane formation, and cytoskeleton-driven structures like podosomes, all pointing to membrane dynamics and trafficking as a common theme, despite diverse specific functions.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030242","count":1},{"id":"GO:0006810","count":1},{"id":"GO:0050826","count":1},{"id":"GO:0032005","count":1},{"id":"GO:0022617","count":1}]},{"hash":"1550331586776278572","title":"Neuronal signaling and potassium homeostasis","description":"The top GO terms point to neuronal signaling (dopamine receptor pathway, pain perception, prostaglandin response) and direct regulation of membrane potential via potassium transport and homeostasis, suggesting a cluster focused on neuronal excitability and signaling via ion gradients. Some terms (thermogenesis, proliferation) are less aligned but do not dominate the set, so the core theme remains neuronal signaling with ion regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007191","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0071380","count":2},{"id":"GO:0042391","count":2},{"id":"GO:0097623","count":2}]},{"hash":"1838707735916272262","title":"Aromatic Compound Catabolism","description":"The top GO terms point to multiple catabolic pathways for aromatic substances (phenylalanine/tyrosine derivatives, 3-phenylpropionate, 4-hydroxyphenylacetate) and related metabolic routes (menaquinone biosynthesis, nicotinate/nicotinamide riboside catabolism), suggesting a shared theme of aromatic compound breakdown and NAD-related metabolism. Some terms about immune regulation and nuclear export appear as outliers, likely incidental annotations.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046638","count":2},{"id":"GO:0046827","count":2},{"id":"GO:0019571","count":1},{"id":"GO:0006559","count":1},{"id":"GO:0006572","count":1}]},{"hash":"1097537453702818244","title":"ER Protein Folding and Membrane Targeting","description":"Top GO terms cluster around protein refolding, unfolded protein response, SRP-dependent cotranslational and post-translational targeting to membranes, and translocation, pointing to a theme of ER-associated protein quality control and trafficking to membranes. Some terms touch on stress responses and metal cofactor assembly, but the core signal is proteins being properly folded and directed to membranes, consistent with ER processing pathways.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":4},{"id":"GO:1903751","count":4},{"id":"GO:0070880","count":4},{"id":"GO:0034620","count":4},{"id":"GO:0006616","count":4}]},{"hash":"2276697917789393954","title":"Renal development and immune signaling","description":"This cluster features strong signals for metanephric proximal/distal tubule and mesonephric duct development (kidney-related development) alongside multiple immune signaling pathways (complement activation via lectin pathway; Fc-gamma receptor signaling; stimulatory C-type lectin receptor signaling) and leukocyte trafficking terms. Additional terms for platelet activation regulation, cartilage condensation, and oxidative stress-induced senescence hint at broader developmental and stress-response processes. The co-occurrence of renal development terms with immune-related pathways suggests a module where development intersects with immune signaling, making \u201cRenal development and immune signaling\u201d a plausible, concise label.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0072237","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0050901","count":5},{"id":"GO:0010572","count":5},{"id":"GO:0038094","count":5}]},{"hash":"1590556958011165048","title":"Hippo signaling\u2013driven growth control","description":"The top terms are dominated by Hippo signaling and associated growth-control processes (hippo signaling, centrosome cycle, regulation of JNK, ER-stress\u2013related apoptotic signaling, and proliferation in epithelial tissues), suggesting the cluster centers on growth regulation and stress-responsive proliferation pathways, despite some secondary terms. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035329","count":4},{"id":"GO:0070059","count":4},{"id":"GO:0072584","count":3},{"id":"GO:0033598","count":3},{"id":"GO:1990804","count":3}]},{"hash":"1589207213669295614","title":"Ubiquitin-Regulated TNF/NF-\u03baB Signaling","description":"The top terms cluster around ubiquitination (protein autoubiquitination; ubiquitin-dependent protein catabolic process) and inflammatory signaling (TNF-mediated signaling; NF-\u03baB activation), with links to JNK regulation and apoptosis. This points to a module where ubiquitin turnover modulates TNF/NF-\u03baB signaling and cell fate decisions, making this a cohesive functional theme for the cluster.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":3},{"id":"GO:1903762","count":3},{"id":"GO:1901253","count":3},{"id":"GO:0046328","count":2},{"id":"GO:0033209","count":2}]},{"hash":"2188504690644443065","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030578","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0046597","count":4},{"id":"GO:1900458","count":4},{"id":"GO:0048384","count":4}]},{"hash":"1976107547802837531","title":"Centrosome-Localized Actin Remodeling","description":"This cluster centers on centrosome localization establishment and actin cytoskeleton regulation, featuring actin nucleation, formin-mediated actin assembly, barbed-end capping, and positive regulation of GTPase activity, along with links to cell shape regulation and signaling (e.g., TGF-beta, tyrosine phosphorylation). The convergence of these actin dynamics and centrosome-related terms suggests proteins coordinating centrosome positioning with actin remodeling, with some neuronal signaling context implied by synaptic depression terms.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051660","count":2},{"id":"GO:2000251","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0051016","count":2}]},{"hash":"2130360317100803324","title":"Adhesion-Linked Cytoskeleton Remodeling","description":"This cluster centers on processes connecting cell\u2013cell adhesion with cytoskeletal dynamics, including desmosome assembly and regulation of actin cytoskeleton by cell\u2013cell adhesion, as well as cortical microtubule localization. Although some terms pertain to development/differentiation contexts (metanephros morphogenesis, lung induction, neuron differentiation), the shared theme appears to be how adhesion interfaces with the cytoskeleton to govern cell shape, junctions, and division.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000288","count":2},{"id":"GO:0003338","count":1},{"id":"GO:0000011","count":1},{"id":"GO:0072699","count":1},{"id":"GO:0001711","count":1}]},{"hash":"317598030911186434","title":"Innate and Adaptive Immune Response","description":"This cluster is strongly enriched for both innate and adaptive immune terms (innate immune response, defense response to virus, adaptive immune response) and lymphocyte regulation (B cell homeostasis, negative regulation of activated T cell proliferation), suggesting a function centered on immune signaling and lymphocyte control. Some non-immune terms appear, but the immune-theme is dominant. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0046007","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0002250","count":3}]},{"hash":"429342460452669848","title":"DNA Replication and Repair","description":"This cluster is dominated by GO terms for DNA replication, leading strand elongation, UV-damage excision repair, and error-free translesion synthesis, indicating core involvement in genome duplication and damage tolerance. Other terms appear incidental rather than defining the main function, suggesting the primary theme is DNA replication/repair machinery.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070987","count":5},{"id":"GO:0006272","count":5},{"id":"GO:0070914","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0090305","count":4}]},{"hash":"57246430352009020","title":"Translational control and ribosome biogenesis","description":"Most terms cluster around translation (GO:0006412), ribosome biogenesis (GO:0042254), and regulation of translational fidelity (GO:0045903, GO:1990145, GO:0010998), suggesting a core theme of how proteins are synthesized and their accuracy. An antibiotic response and initiation regulation by eIF2\u03b1 phosphorylation further support a translation-centric cluster, though a single item mentions neuromuscular junction synaptic assembly as a potential outlier. Overall, the cluster centers on translating machinery and its regulation.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0006407","count":2},{"id":"GO:0045903","count":2}]},{"hash":"2060138221471981506","title":"Epithelial Polarity and Cell Migration","description":"The dominant signals are epithelial cell polarity establishment, cell migration, and actin filament bundle assembly, indicating a core role in cytoskeletal organization and directed movement; the remaining terms suggest peripheral links to endothelial/heart development and immune signaling, but do not override the central polarity/motility theme.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0071353","count":2},{"id":"GO:0050960","count":1}]},{"hash":"166019484873283014","title":"mRNA Splicing Regulation and Export","description":"The GO terms point to regulation of pre-mRNA splicing via the spliceosome, mRNA stability, export from the nucleus, and splice-site recognition, indicating these proteins function in nuclear mRNA processing and maturation, including splicing regulation and mRNA fate decisions.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":4},{"id":"GO:0031047","count":4},{"id":"GO:1901407","count":4},{"id":"GO:0010610","count":3},{"id":"GO:0048255","count":3}]},{"hash":"1653761025720820229","title":"DNA replication and genome maintenance proteins","description":"The top terms are concentrated around DNA replication (replication initiation, prereplicative complex assembly) and genome stability (HR repair regulation, DNA damage checkpoint regulation), suggesting the cluster groups proteins involved in replication and maintenance of genomic integrity. A few terms (lysosome targeting, dUMP catabolic process) appear less connected and may reflect annotation noise or multifunctionality. The lack of edges indicates the grouping is annotation-based rather than based on strong direct interactions, but the core theme remains replication/maintenance.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":1},{"id":"GO:0006270","count":1},{"id":"GO:0030466","count":1},{"id":"GO:1902985","count":1},{"id":"GO:0010569","count":1}]},{"hash":"173210851258977568","title":"Unknown","description":"These proteins link to a highly diverse set of GO terms, including insulin signaling, cerebellar cortex formation, Bergmann glial differentiation, mitotic cell cycle progression, axon regeneration, T cell receptor signaling, endothelial cell migration, and cellular responses to metals. The terms do not converge on a single shared pathway or function, suggesting the cluster captures multiple distinct processes rather than a coherent biological theme.","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":3},{"id":"GO:0021697","count":3},{"id":"GO:0060020","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0000086","count":3}]},{"hash":"2122651935429600818","title":"Budding Yeast Cytokinesis and Spindle Checkpoints","description":"This cluster is dominated by GO terms related to septin ring assembly, bud neck localization, and spindle-related checkpoints (mitotic spindle assembly/checkpoint signaling, spindle orientation checkpoint), all pointing to cytokinesis and cell division in budding yeast; a few terms are broader or unrelated noise (e.g., iron homeostasis or general growth regulation) but do not overshadow the main theme.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046621","count":1},{"id":"GO:0031578","count":1},{"id":"GO:0006879","count":1},{"id":"GO:0097271","count":1},{"id":"GO:0042981","count":1}]},{"hash":"705865631366881575","title":"Membrane Transporters and Ion Homeostasis","description":"The GO terms are dominated by transmembrane transport activities for various substrates (fructose, chloride, L-aspartate, oxalate), plus processes related to membrane potential and intracellular pH, with gastric acid secretion also aligning with proton transport. While a few terms like transcription regulation and sporulation appear as outliers, the transport-related terms form a coherent theme pointing to membrane transporters and ion homeostasis as the cluster\u2019s core function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0015755","count":1},{"id":"GO:1902476","count":1},{"id":"GO:0042391","count":1},{"id":"GO:0051454","count":1}]},{"hash":"997769978942387147","title":"Nucleotide and NAD Salvage Metabolism","description":"This cluster is dominated by GO terms for nucleotide salvage and related catabolic pathways (AMP/UMP salvage, inosine and deoxyguanosine catabolism) and NAD-related salvage (nicotinamide riboside and nicotinate nucleotide salvage). A single term for menaquinone biosynthesis appears incidental, and a eukaryotic immune term likely reflects annotation noise. Overall, the proteins show a cohesive theme around nucleotide/NAD salvage and processing.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":2},{"id":"GO:0019358","count":1},{"id":"GO:0006738","count":1},{"id":"GO:0006148","count":1},{"id":"GO:0034418","count":1}]},{"hash":"1791829957126487544","title":"Cerebellar neural development and insulin signaling","description":"The cluster centers on neural development in the cerebellum, with terms like cerebellar cortex formation and Bergmann glial cell differentiation, plus the insulin receptor signaling pathway, suggesting insulin-mediated regulation of cerebellar neural development. Other terms touch on cell-cycle control and axon regeneration, which can co-occur in neural contexts but are less core here. Overall, the core theme is cerebellar neural differentiation influenced by insulin signaling.","confidence":"Medium","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":4},{"id":"GO:0021697","count":4},{"id":"GO:0060020","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0008285","count":4}]},{"hash":"820846104647965413","title":"Mitophagy and ubiquitin signaling","description":"The cluster\u2019s top GO terms center on mitophagy and autophagosome engulfment, plus ubiquitin-mediated regulation (K29-linked ubiquitination and deubiquitination control), which together point to autophagy regulation via the ubiquitin system. GO terms about GTPase activity regulation also support vesicle trafficking control linked to autophagy. Some RNA export and histone ubiquitination terms appear less directly connected but may reflect broader stress responses co-occurring with autophagy. ","confidence":"Medium","size":5,"edges":5,"triangles":2,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0061734","count":4},{"id":"GO:0035519","count":4},{"id":"GO:0010793","count":4},{"id":"GO:2000238","count":4}]},{"hash":"2199758330962139612","title":"Embryonic tissue differentiation","description":"The GO terms are all related to developmental differentiation and morphogenesis across multiple tissues and organs (inner ear, labyrinthine layer, cardiac neural crest, kidney glomeruli, pancreas, oligodendrocytes, mesenchyme, etc.), suggesting the proteins participate in broad embryonic development programs rather than a single tissue-specific function.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042491","count":5},{"id":"GO:0007540","count":5},{"id":"GO:0072277","count":5},{"id":"GO:0003253","count":5},{"id":"GO:0003329","count":5}]},{"hash":"413978822236306356","title":"Developmental transcriptional regulation","description":"The cluster centers on transcription-related GO terms (DNA-templated transcription; negative regulation of RNA polymerase II preinitiation) and broad tissue development categories (nervous system, inner ear, skeletal muscle, endocrine pancreas, gonads, Harderian gland) plus circadian entrainment, suggesting a group of transcriptional regulators coordinating development across multiple tissues.","confidence":"Medium","size":5,"edges":6,"triangles":2,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0071353","count":2},{"id":"GO:0017055","count":2},{"id":"GO:0007399","count":2},{"id":"GO:2000020","count":2}]},{"hash":"1316281969475640597","title":"Nuclear DNA repair and chromatin regulation","description":"This cluster\u2019s strongest signals are base-excision repair (DNA maintenance) and histone-related modification (chromatin regulation), suggesting a nuclear, genome-maintenance function. While some terms point to differentiation or development, these are less central to the set, making the core theme nuclear DNA repair and chromatin state maintenance.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":2},{"id":"GO:0006284","count":2},{"id":"GO:0001833","count":1},{"id":"GO:0045598","count":1},{"id":"GO:0030154","count":1}]},{"hash":"51004442454397774","title":"Stem cell transcriptional regulation and chromatin remodeling","description":"This cluster centers on stem cell biology and transcriptional control. The top GO terms include somatic stem cell population maintenance, regulation and negative regulation of DNA-templated transcription, as well as cell proliferation and differentiation, pointing to roles in maintaining stem cell states and guiding fate through transcriptional programs. The mention of histone exchange (chromatin remodeling) suggests epigenetic regulation as part of this control. Despite zero edges among proteins, the functional theme is coherent around stem cell transcriptional regulation and chromatin dynamics.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035019","count":1},{"id":"GO:0043486","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0045892","count":1},{"id":"GO:0008283","count":1}]},{"hash":"258669413072676114","title":"Unknown","description":"The top GO terms include steroid-related biosynthesis (glucocorticoid, C21-steroid, androgen) alongside development, pigment, and plant/bacterial metabolism terms, which makes the cluster's functional coherence unclear. There isn't a single dominant biological theme uniting these terms, so a specific label can't be confidently assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006704","count":3},{"id":"GO:0030324","count":3},{"id":"GO:0042619","count":3},{"id":"GO:0042574","count":3},{"id":"GO:0045150","count":3}]},{"hash":"207706503306919447","title":"Embryonic mesoderm development and organogenesis","description":"The terms cluster around embryogenesis, especially mesoderm development and organogenesis (mesoderm development, left-right patterning, cartilage morphogenesis, endocardial cushion EMT, placental and endocrine system development, roof of the mouth). This supports a cohesive program for mesoderm-derived tissue formation rather than routine cellular processes, justifying the label.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0032298","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0007498","count":4}]},{"hash":"2190550106389559784","title":"Cardiac development and sarcomere organization","description":"The top GO terms point to heart development, sarcomere organization, and angiogenesis, with supporting signals for proteolysis and voltage-gated potassium channel clustering, all of which fit a theme of cardiac muscle formation, remodeling, and electrophysiology. While some terms touch broader development or cell junctions, the clustering of heart-related processes suggests this cluster centers on cardiac muscle development and structural organization.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0045163","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0045214","count":2}]},{"hash":"756465960710506957","title":"Immune activation and apoptosis signaling","description":"The top GO terms cluster around immune cell activation (T cell proliferation, TNF and interferon production, NF-kappaB signaling) and apoptosis (extrinsic pathway and execution phase), with a note on B cell regulation. This combination indicates proteins involved in immune signaling coupled to regulated cell death, supporting a label focused on immune activation and apoptosis pathways.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0097192","count":3},{"id":"GO:0032729","count":3},{"id":"GO:0097202","count":3},{"id":"GO:0030889","count":3}]},{"hash":"1853667316851559904","title":"Cytoskeletal remodeling and cell migration signaling","description":"The cluster shows a clear emphasis on cytoskeletal dynamics and motility: filopodium assembly, regulation of Rac and Rho signaling, cell migration, and positive regulation of adhesion-dependent spreading, along with negative regulation of Ras signaling. While some terms touch on broader developmental or immune contexts (NK T cell differentiation, heart development, IL-7 response, insulin signaling), the shared theme is signaling pathways that drive actin remodeling and cell movement. ","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001865","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0098761","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0046847","count":3}]},{"hash":"1543834178152529632","title":"Schwann cell development and PNS myelination","description":"The cluster is dominated by terms related to peripheral nervous system development and myelination, notably Schwann cell development and myelination in the PNS, which strongly indicate a glial/nerve-tract focus. Additional terms like epithelial-to-mesenchymal transition and actin cytoskeleton remodeling fit with neural crest\u2013derived Schwann cell biology and migration, while calcium transport aligns with neuronal signaling. Some heart development signals appear less central but don\u2019t override the primary neural/glial theme.","confidence":"High","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051764","count":5},{"id":"GO:1905205","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0070588","count":5},{"id":"GO:0001837","count":5}]},{"hash":"2220367977475401753","title":"Ubiquitin-Dependent Proteolysis and Vesicle Trafficking","description":"The top GO terms are dominated by ubiquitin-dependent protein catabolic processes, with additional terms pointing to vesicle trafficking (COPII-coated budding) and related transport (intraciliary retrograde). Growth-related and signaling terms (positive regulation of cell proliferation and TORC1 signaling) suggest a broader role in proteostasis and trafficking that influences cell growth, with some neural-development related terms. Together, this cluster centers on ubiquitin-mediated protein turnover coupled with vesicular trafficking.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":2},{"id":"GO:0042787","count":2},{"id":"GO:1904263","count":1},{"id":"GO:0050773","count":1},{"id":"GO:0031915","count":1}]},{"hash":"2135586498388907194","title":"Neurodevelopment and autophagy","description":"The listed GO terms cluster around brain and nervous system development (brain development; nervous system development) and core cellular homeostasis processes (ubiquitin-dependent protein catabolic process; autophagy), with connections to transcription regulation and cell adhesion. This pattern suggests proteins involved in neurodevelopment where protein turnover and gene regulation are key, and where cell\u2013cell interactions contribute to neural tissue organization.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0006914","count":2},{"id":"GO:2000312","count":2},{"id":"GO:1903142","count":2}]},{"hash":"676089078143805555","title":"Diverse carbohydrate and amino acid catabolism","description":"The top GO terms point to catabolic pathways for multiple sugars (rhamnose, gluconate, glucuronate, arabinose, fucose, xylulose, glycerol) and amino acid metabolism (L-glutamine, L-arginine biosynthesis). While quorum sensing appears, the dominant theme is metabolism of various carbon sources, suggesting a cluster of proteins involved in diverse carbon-source catabolism. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006541","count":2},{"id":"GO:0006526","count":2},{"id":"GO:0009372","count":2},{"id":"GO:0019301","count":2},{"id":"GO:0019521","count":2}]},{"hash":"1274437625766262739","title":"Retinal GPCR-opsin Signaling and Visual Perception","description":"This cluster is driven by vision-related GO terms, including visual perception and regulation of opsin-mediated signaling, along with GPCR desensitization and photoreceptor-related microtubule transport, suggesting a retinal signaling/function theme. Some immune and cardiac-related terms appear but do not define the main function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0035372","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0007507","count":2}]},{"hash":"65294400263766544","title":"Hematopoietic and immune receptor signaling","description":"GO terms center on receptor-initiated signaling in immune and hematopoietic cells: B cell receptor signaling, Fc-epsilon receptor signaling, Kit signaling, and IL-2 production. Additional terms point to megakaryocyte development and angiogenesis, with downstream ERK and Rho pathways. The cluster thus seems to group proteins involved in diverse, but related, hematopoietic/immune signaling networks rather than a single pathway, supporting a label around hematopoietic and immune receptor signaling.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0035855","count":3},{"id":"GO:0001525","count":3}]},{"hash":"674232682065658016","title":"Multitissue Development and Morphogenesis","description":"This cluster contains GO terms spanning retina, heart, bone (osteoblast), gonad, digestive tract, cerebellar signaling, and myoblast proliferation, along with regulation of Wnt signaling, indicating broad developmental processes across multiple tissues rather than a single specific function. The name reflects general embryonic organogenesis and tissue morphogenesis themes present in the set.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":5},{"id":"GO:0002087","count":5},{"id":"GO:0002076","count":5},{"id":"GO:0061296","count":4},{"id":"GO:0021937","count":4}]},{"hash":"1741479471722358866","title":"Embryonic Development and Morphogenesis","description":"This cluster is best labeled Embryonic Development and Morphogenesis because the most frequent GO terms center on embryogenesis, tissue morphogenesis, and organ patterning (heart/endocardial cushion formation, placenta, cartilage, left-right patterning, endocrine/ pancreatic development) across diverse tissues. A few terms related to RNA splicing and ribosomal export appear, likely reflecting general gene expression activity rather than a core function of the cluster.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0003198","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060972","count":4}]},{"hash":"240198196088382519","title":"Microtubule organization, mechanosensation, and cell division","description":"The cluster centers on microtubule-based processes (cytoplasmic microtubule organization) and mechanosensory signaling (positive regulation of mechanosensory behavior and detection of mechanical stimulus in touch), with additional terms related to neuron differentiation, mitotic/cytokinesis processes, and spindle assembly. This suggests a cohesive theme around microtubule dynamics supporting both sensory signaling and cell division in neural contexts.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0031122","count":5},{"id":"GO:1905792","count":5},{"id":"GO:1905789","count":5},{"id":"GO:0071353","count":5},{"id":"GO:1902408","count":5}]},{"hash":"250061083877574817","title":"RNA metabolism and processing","description":"The terms are dominated by RNA-centric processes: mRNA decay (both deadenylation-independent and dependent), mRNA catabolic process regulation, cytoplasmic translation, and snoRNA splicing, suggesting a core theme around RNA metabolism and gene expression control, with immune development and signaling terms as less central outliers.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031086","count":1},{"id":"GO:0097403","count":1},{"id":"GO:0046782","count":1},{"id":"GO:0071385","count":1},{"id":"GO:1900153","count":1}]},{"hash":"636545665265795867","title":"Ion Transport and Cell Volume Regulation","description":"The top GO terms are dominated by membrane transport: potassium ion transport, magnesium ion transmembrane transport, and transepithelial water transport, along with negative regulation of cell volume. These collectively suggest a common theme around membrane transport and cellular volume control. Some terms (retina development, certain biosynthetic processes) are less aligned and may reflect broader or secondary annotations, but the strongest signal points to transport and volume regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006813","count":4},{"id":"GO:0006633","count":4},{"id":"GO:0019343","count":3},{"id":"GO:0006535","count":3},{"id":"GO:0035377","count":3}]},{"hash":"2122221743035669587","title":"Ubiquitin-dependent degradation and endosomal sorting","description":"The top GO terms cluster around ubiquitin-protein catabolic processes (including ERAD and multivesicular body sorting) and vesicular trafficking from endosomes to lysosomes, all tied to ubiquitin-mediated degradation and ESCRT/MVB pathways. This suggests a proteostasis-focused cluster centered on ubiquitin tagging and subsequent sorting/degradation, with a few peripheral lineage-specific terms appearing incidental. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0030433","count":2},{"id":"GO:1903774","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0030216","count":1}]},{"hash":"1645305077595609076","title":"Neural signaling and Schwann cell development","description":"The top terms emphasize neuronal communication (excitatory postsynaptic potential, long-term potentiation) and Schwann cell development, suggesting a focus on neural signaling and peripheral glial biology. Other terms like innate immune response and apoptosis regulation are present but less central, so the label captures the main theme with some noise. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043065","count":4},{"id":"GO:0060079","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0014044","count":3},{"id":"GO:0031532","count":3}]},{"hash":"1581690290019605811","title":"RNA Methylation and Processing","description":"The top GO terms are dominated by RNA-related modifications and maturation: tRNA methylation, rRNA processing, and protein methylation, suggesting an RNA modification/maturation cluster. Some other terms (like cobalamin biosynthesis) can relate to methylation-associated enzymes, but several signaling/development terms appear less cohesive with the core RNA-focused annotations, especially given the small protein set. Overall, the strongest theme is RNA modification and processing.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030488","count":3},{"id":"GO:0009236","count":3},{"id":"GO:0006479","count":3},{"id":"GO:0006364","count":3},{"id":"GO:0060396","count":3}]},{"hash":"324643209298845603","title":"Cell Fate and Differentiation Signals","description":"The terms point to differentiation and development across multiple lineages (granulocyte and dendritic cell differentiation, neuron development, and mesoderm/fate specification through BMP signaling) with regulatory elements like cell fate commitment and immune signaling modulation. Though a couple of terms pertain to nuclear organization or histone modification, the shared theme is lineage specification and differentiation control, justifying a label around cell fate/differentiation across lineages.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060803","count":5},{"id":"GO:0071340","count":5},{"id":"GO:0030578","count":5},{"id":"GO:0030851","count":5},{"id":"GO:0043011","count":5}]},{"hash":"73202352237279597","title":"Unknown","description":"The top GO terms span both plant-specific processes (glucosinolate and cytokinin signaling, cellulose catabolic activity) and animal development/signaling (lens fiber differentiation, neural plate morphogenesis, JAK/FGF/MAPKKK pathways), and there are no edges connecting the proteins, so there is no coherent unifying function to name the cluster.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0019762","count":1},{"id":"GO:0008286","count":1},{"id":"GO:0090080","count":1}]},{"hash":"941290406960388666","title":"Unknown","description":"The terms span metabolic regulation (glucose/insulin signaling), neural/oligodendrocyte differentiation, vascular processes (angiogenesis, coagulation), cell migration, estrous cycle, and chemical response, with no single coherent function tying all proteins together. This suggests an Unknown cluster.","confidence":"","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046325","count":1},{"id":"GO:0048714","count":1},{"id":"GO:1903165","count":1},{"id":"GO:0030194","count":1},{"id":"GO:0045765","count":1}]},{"hash":"1893286350988666789","title":"GTPase signaling and actin-driven morphogenesis","description":"This cluster is dominated by GO terms for small GTPase\u2013mediated signal transduction and actin cytoskeleton dynamics (ruffle assembly, establishment of actin polarity), with related themes in neural and epithelial morphogenesis (auditory receptor morphogenesis, neuronal migration). The common thread appears to be GTPase-regulated cytoskeletal remodeling driving cell shape changes during development and morphogenesis.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":3},{"id":"GO:0002093","count":2},{"id":"GO:0043652","count":2},{"id":"GO:0097178","count":2},{"id":"GO:0021799","count":2}]},{"hash":"2119095916638431815","title":"Neuronal adhesion and synapse assembly","description":"The top GO terms are dominated by neuron cell-cell adhesion, calcium-dependent adhesion, and presynaptic active zone assembly, with supporting neural development terms like radial glial differentiation and corticospinal tract morphogenesis. This points to a shared role in neural connectivity and synapse formation rather than other processes.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":3},{"id":"GO:1902910","count":2},{"id":"GO:0060019","count":2},{"id":"GO:0070445","count":2},{"id":"GO:0045317","count":2}]},{"hash":"1013460333057167092","title":"Synapse formation and neuronal development","description":"The GO terms are dominated by nervous system development, synapse assembly, serotonergic neuron axon guidance, and cell adhesion, indicating a core function in neuron development and synaptogenesis; a few terms about ossification and valve formation are likely incidental. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":4},{"id":"GO:0007157","count":4},{"id":"GO:0051965","count":4},{"id":"GO:0043931","count":4},{"id":"GO:0072307","count":3}]},{"hash":"706456602412007815","title":"Histone ubiquitination and chromatin modification","description":"This cluster centers on ubiquitin-mediated regulation of histones and chromatin states, including H2A ubiquitination, histone acetylation and catabolic processes, and ubiquitin-dependent protein turnover. The presence of links to NF-\u03baB and JNK signaling and V(D)J recombination suggests a broader role in chromatin remodeling that influences immune-related gene regulation. Confidence reflects a coherent, high-level theme around ubiquitin-driven chromatin regulation rather than a specific enzymatic pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0070535","count":5},{"id":"GO:2000620","count":5},{"id":"GO:0051865","count":5},{"id":"GO:0036205","count":5},{"id":"GO:0042787","count":5}]},{"hash":"1445994586036772807","title":"Broad-Substrate Membrane Transporters","description":"These proteins show a pattern of transmembrane transport across a diverse set of substrates (nitrate, phosphate, vitamins, arabinose, galactose, fucose, sugars, etc.), plus a neuronal vesicle loading term, pointing to a cluster of membrane transporter proteins with broad substrate specificity and potential vesicular transport roles in neurons.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":4},{"id":"GO:0035435","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0015751","count":3},{"id":"GO:0035725","count":3}]},{"hash":"49337009765031351","title":"Synapse Formation and Plasticity","description":"The top GO terms cluster around neural synapse structure and function\u2014synapse assembly, dendritic spine morphogenesis, long-term potentiation, and regulation of excitatory postsynaptic potentials\u2014along with social and vocalization behaviors that depend on neural circuits. This suggests the proteins participate in neuronal synapse formation and plasticity, with membrane remodeling (phospholipid catabolism) possibly supporting synaptic changes. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009395","count":2},{"id":"GO:2000463","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0007416","count":2}]},{"hash":"442189415107224648","title":"Heart and skeletal development signaling regulation","description":"The cluster centers on heart development and skeletal formation processes, including heart field specification, intramembranous ossification, and regulation of chondrocyte development, with supporting signaling pathways such as Wnt and MAPK regulation. This suggests a cohesive theme of cardiovascular and skeletal development signaling, despite a few peripheral terms (e.g., mismatch repair regulation, synaptic plasticity) that appear less connected.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0035414","count":1},{"id":"GO:0003139","count":1},{"id":"GO:0043407","count":1},{"id":"GO:0032423","count":1},{"id":"GO:0060087","count":1}]},{"hash":"1078364129188747588","title":"Neuronal axon guidance and synapse assembly","description":"This cluster is dominated by GO terms related to neuronal pathfinding and connectivity (corticospinal and retinal ganglion cell axon guidance, axon extension, and positive regulation of synapse assembly), suggesting a core role in neural wiring and synapse formation. Some terms reference broader stress or inflammatory responses, but the axon guidance/synapse formation theme is the strongest signal. Obsolete cross-linking term appears, but does not change the main interpretation.","confidence":"High","size":5,"edges":6,"triangles":2,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0021972","count":4},{"id":"GO:0019800","count":4},{"id":"GO:0042346","count":4},{"id":"GO:0048846","count":4},{"id":"GO:0090260","count":4}]},{"hash":"1656550690001842190","title":"EGF-induced cytoskeletal remodeling and fibroblast migration","description":"The terms center on ruffle assembly and responses to epidermal growth factor and mechanical stimuli, with positive regulation of fibroblast migration, indicating signaling-driven actin remodeling that leads to cell movement; a few items are obsolete or less directly connected but do not override the core theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097178","count":2},{"id":"GO:0042993","count":1},{"id":"GO:0097201","count":1},{"id":"GO:0071260","count":1},{"id":"GO:1903061","count":1}]},{"hash":"1781093749671040655","title":"Embryonic Morphogenesis and Patterning","description":"This cluster centers on development and tissue morphogenesis, with GO terms like roof of mouth development, cartilage morphogenesis, left-right pattern formation, and hair follicle morphogenesis, plus endocrine system development and placenta-related differentiation. These recurrent themes point to a cohesive role in embryonic organogenesis and patterning across multiple tissues, making a developmental/morphogenetic label appropriate.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":4},{"id":"GO:0006366","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0060972","count":3},{"id":"GO:1903026","count":3}]},{"hash":"196914156504132022","title":"PNS axonogenesis and Schwann cell differentiation","description":"The cluster is dominated by terms related to peripheral nervous system development and axon biology: PNS axonogenesis, PNS axon regeneration, Schwann cell proliferation, neurofilament bundle assembly, axon diameter regulation, and microtubule cytoskeleton polarity. A glial differentiation term (Bergmann glial cell differentiation) supports the glial context, while an outlier immune term (complement activation) is likely incidental. Overall, the core theme is nerve growth and glial support in the PNS. ","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":4},{"id":"GO:0060020","count":4},{"id":"GO:0030951","count":4},{"id":"GO:0090343","count":4},{"id":"GO:0010625","count":4}]},{"hash":"1089831633797888425","title":"Hair follicle keratinization","description":"This cluster is defined by GO terms related to the hair cycle and keratinization, indicating involvement in hair follicle maturation and keratin production.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042633","count":5},{"id":"GO:0031424","count":4}]},{"hash":"2270646466434079932","title":"Vacuolar protein targeting and ion transport","description":"The top GO terms cluster around vacuolar processes (targeting to vacuole, vacuole organization, vacuolar acidification) and ion/energy-related transport (sodium and copper ion transport, proton transmembrane transport, proton motive force-driven ATP synthesis), indicating a cohesive module focused on vacuole function, ion homeostasis, and proton-gradient\u2013driven energetics. This supports a single, coherent theme rather than unrelated processes.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006623","count":4},{"id":"GO:0007033","count":4},{"id":"GO:0015991","count":4},{"id":"GO:0006626","count":4},{"id":"GO:0006814","count":4}]},{"hash":"2259487365781022662","title":"Ribosome biogenesis and translation","description":"The proteins are enriched for translation and ribosome-related GO terms, including translation (GO:0006412), ribosomal subunit assembly (GO:0000027, GO:0000028), ribosome biogenesis, and rRNA maturation, plus export of the large subunit, pointing to a shared role in ribosome assembly and protein synthesis. The presence of mitochondrial translation termination and stringent response terms reflects broader regulation of translation but does not alter the core ribosome/translation theme.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006415","count":1},{"id":"GO:0000027","count":1},{"id":"GO:0015968","count":1},{"id":"GO:0070126","count":1}]},{"hash":"1920111610314547680","title":"mRNA splicing and stability regulation","description":"The cluster is dominated by GO terms tied to post-transcriptional mRNA processing, including mRNA splicing via the spliceosome, splice site recognition, mRNA export, stabilization, and regulatory mechanisms such as ncRNA-mediated gene silencing. This pattern suggests a cohesive group of proteins involved in RNA maturation and quality control within the nucleus and during early RNA handling.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048026","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0010610","count":2},{"id":"GO:0048255","count":2},{"id":"GO:0006376","count":2}]},{"hash":"341091999452124125","title":"Nucleotide metabolism and cofactor biosynthesis","description":"Most terms point to nucleotide biosynthesis and related cofactor production (AMP/CDP/ADP biosynthesis, purine interconversion, NAD+ biosynthesis, CoA biosynthesis, AMP salvage). The development terms may be incidental annotations; the core theme remains nucleotide and cofactor metabolism.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001889","count":3},{"id":"GO:0015937","count":3},{"id":"GO:0046041","count":3},{"id":"GO:0015951","count":3},{"id":"GO:0006172","count":3}]},{"hash":"827244536449603244","title":"Microtubule Dynamics and Spindle Organization","description":"The top GO terms point to microtubule cytoskeleton regulation, including plus-end\u2013directed vesicle transport, microtubule polarity establishment, and mitotic chromosome alignment, with additional axonemal depolymerization context. This cohesive theme suggests proteins coordinating microtubule dynamics and spindle organization during division and intracellular transport, despite some peripheral terms. ","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0033624","count":4},{"id":"GO:0032487","count":4},{"id":"GO:0072383","count":4},{"id":"GO:0030951","count":4},{"id":"GO:0007080","count":4}]},{"hash":"986816575228763707","title":"Protein quality control under heat stress","description":"This cluster centers on proteostasis during heat exposure, with terms for response to heat, unfolded/misfolded protein handling, misfolded protein transport, and nuclear ubiquitin-proteasome\u2013mediated quality control, indicating a cohesive proteostasis function under thermal stress.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":1},{"id":"GO:0032781","count":1},{"id":"GO:1900035","count":1},{"id":"GO:0009408","count":1},{"id":"GO:0006452","count":1}]},{"hash":"1507038883879708070","title":"NMJ Lipid Metabolism and Organelle Inheritance","description":"These proteins cluster around neuromuscular regulation (NMJ processes and synaptic assembly), lipid metabolism (lipid droplets, adipose development), and organelle dynamics (mitochondrial membrane potential, protein import into mitochondrial matrix, peroxisome inheritance). The convergence of energy/lipid handling with mitochondrial/peroxisomal functions and NMJ modulation suggests a cohesive theme of how lipid metabolism and organelle inheritance support neuromuscular function and remodeling.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045886","count":2},{"id":"GO:0048698","count":2},{"id":"GO:0009838","count":2},{"id":"GO:0045033","count":2},{"id":"GO:0050905","count":2}]},{"hash":"2303030572199774061","title":"Lectin- and Fc receptor signaling cluster","description":"The top GO terms cluster around innate immune signaling via stimulatory C-type lectin receptors, lectin pathway complement activation, Fc-gamma receptor signaling, leukocyte tethering/rolling, and related platelet activation. While kidney development terms appear among the annotations, the dominant theme is lectin- and Fc-receptor\u2013mediated immune signaling and leukocyte interactions, suggesting a functional cluster focused on innate immune activation rather than development.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":4},{"id":"GO:0072237","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0050901","count":3},{"id":"GO:0010572","count":3}]},{"hash":"700506776466659177","title":"Unknown","description":"The GO terms span neural development, embryogenesis, gonad development, immune signaling, and even plant hormone regulation, with no single coherent function tying the proteins together. This diversity makes it hard to assign a concise, representative label. ","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0048935","count":3},{"id":"GO:0090009","count":3},{"id":"GO:0061296","count":2},{"id":"GO:0021937","count":2}]},{"hash":"2002555346606091169","title":"Mitophagy and ubiquitin-dependent proteolysis","description":"The cluster\u2019s strongest terms are ubiquitin-dependent protein catabolic process and autophagy of mitochondrion, suggesting a common role in mitochondrial quality control via selective degradation. The other terms are more disparate (e.g., regulation of protein localization to nucleus, motility, and other processes), which may reflect broader regulatory connections or annotation noise.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0000422","count":2},{"id":"GO:0021629","count":2},{"id":"GO:1905437","count":2},{"id":"GO:1900180","count":2}]},{"hash":"2140141687383319193","title":"Renal development proteins","description":"The top GO terms point to metanephric proximal/distal tubule development and mesonephric duct development, indicating a focus on kidney morphogenesis; additional immune signaling terms seem ancillary, not defining the core theme.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0072237","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0050901","count":4},{"id":"GO:0010572","count":4},{"id":"GO:0038094","count":4}]},{"hash":"377556125025023930","title":"Peripheral nerve Myelination and Schwann Cell Development","description":"The top GO terms include myelination in the peripheral nervous system and Schwann cell development, pointing to a cluster centered on Schwann cell maturation and PNS myelination. Additional terms such as epithelial to mesenchymal transition and neural crest\u2013related processes suggest a broader developmental context, while others (cell cycle, chromatin regulation) may reflect general cellular housekeeping in proliferating glial precursors. Overall, the cluster appears to represent proteins involved in PNS myelination and Schwann cell development.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070940","count":3},{"id":"GO:0005981","count":2},{"id":"GO:1905205","count":2},{"id":"GO:2001034","count":2},{"id":"GO:0001837","count":2}]},{"hash":"1226522253217990206","title":"Unknown","description":"The top GO terms span kidney development, several immune signaling pathways, leukocyte trafficking, platelet activation, cartilage condensation, and cellular aging, showing no single cohesive function binding all terms. This suggests the cluster does not reflect one clear biological theme, so Unknown with no confidence is appropriate.","confidence":"","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0072237","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0050901","count":3},{"id":"GO:0010572","count":3},{"id":"GO:0038094","count":3}]},{"hash":"584784327865255888","title":"Lectin receptor\u2013mediated innate immunity","description":"This cluster is dominated by GO terms related to innate immune recognition and signaling, including phagocytosis recognition, complement activation via the lectin pathway, leukocyte tethering/rolling, Fc-gamma receptor signaling, and C-type lectin receptor signaling, suggesting a cohesive role in lectin/Fc receptor\u2013mediated immune responses. The non-immune terms appear incidental.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006910","count":2},{"id":"GO:0072237","count":1},{"id":"GO:0001867","count":1},{"id":"GO:0050901","count":1},{"id":"GO:0010572","count":1}]},{"hash":"139984900140806823","title":"Lectin receptor\u2013mediated innate immune signaling","description":"This cluster is dominated by GO terms related to innate immunity and lectin-mediated signaling: cellular response to fungal origin, stimulatory C-type lectin receptor signaling, lectin pathway complement activation, Fc-gamma receptor signaling, leukocyte tethering/rolling, and platelet activation. While a few developmental terms (kidney and cartilage) appear among the terms, the core signal is innate immune recognition and signaling via lectin receptors and related pathways.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":4},{"id":"GO:0072237","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0050901","count":3},{"id":"GO:0010572","count":3}]},{"hash":"739788981770470525","title":"Negative regulators of signaling pathways","description":"Among the top GO terms, many describe down-regulation or modulation of signaling processes (negative regulation of Rac signal transduction, NFAT signaling, MAPK cascade, neutrophil degranulation, blood vessel remodeling, osteoclast differentiation). While some terms touch cytoskeletal organization or apoptotic signaling, the overarching pattern is modulation of signaling rather than core catalytic activity. Thus, a concise label is \"Negative regulators of signaling pathways.\"","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035021","count":3},{"id":"GO:0009395","count":2},{"id":"GO:0051531","count":2},{"id":"GO:0000161","count":2},{"id":"GO:0060313","count":2}]},{"hash":"599923704515173395","title":"Embryonic organ morphogenesis and Wnt regulation","description":"Reason: The GO terms cluster around developmental processes across multiple organs (cochlea morphogenesis, ureteric bud morphogenesis, embryonic digestive tract morphogenesis, endocrine pancreas development) with a key emphasis on regulation of Wnt signaling. Additional transcriptional regulation terms indicate coordinated gene expression control during development. This points to a developmental signaling/regulatory module rather than a single tissue function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030111","count":2},{"id":"GO:0090103","count":2},{"id":"GO:0048557","count":2},{"id":"GO:0090190","count":2},{"id":"GO:0001755","count":2}]},{"hash":"415184791725594702","title":"Neuronal signaling and cytoskeletal regulation","description":"The terms point to neuronal processes (neurotransmitter secretion, long-term synaptic depression, neuron apoptotic regulation) and cytoskeletal dynamics (microtubule organization, muscle filament assembly) with supporting regulatory activities (protein dephosphorylation, cytokinesis control). While Hippo signaling and differentiation terms appear, the strongest shared theme across the cluster is neuronal signaling coupled with cytoskeletal regulation, suggesting a function in synaptic activity and structural modulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035329","count":2},{"id":"GO:0060487","count":2},{"id":"GO:0007269","count":2},{"id":"GO:0032465","count":2},{"id":"GO:0006470","count":2}]},{"hash":"2153215154354632338","title":"Developmental and Innate Immune Signaling","description":"The top GO terms show a mix of developmental processes (heart development; ureteric bud development; mammary gland branching; positive regulation of myoblast proliferation; integrin biosynthetic regulation) and innate immune responses (cellular response to lipopolysaccharide; toll-like receptor 9 signaling pathway; foam cell differentiation). This suggests the proteins participate in signaling that coordinates organ development with immune/inflammatory remodeling, rather than a single, narrow function. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0034162","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0010980","count":2},{"id":"GO:2000288","count":2}]},{"hash":"130782653013430528","title":"Unknown","description":"The GO terms associated with this cluster are highly diverse (fungal defense, vitamin B12 and siroheme biosynthesis, post-translational modifications like neddylation and sumoylation, TLR signaling regulation, pseudohyphal growth, hippocampus development, and lipidation), with no clear unifying function or pathway. The lack of edge structure further suggests no cohesive biological theme, so a single representative label cannot be confidently assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050832","count":1},{"id":"GO:0009236","count":1},{"id":"GO:0019354","count":1},{"id":"GO:0043085","count":1},{"id":"GO:0045116","count":1}]},{"hash":"382236705957838784","title":"Developmental morphogenesis and axon guidance","description":"These proteins are annotated with GO terms centered on development and neuronal wiring: ureteric bud morphogenesis and branching, limbic system development, imaginal disc growth, chemorepulsion in interneuron migration, serotonergic neuron axon guidance, corticospinal neuron axon guidance, and general cell junction (zonula adherens) assembly. The overall theme is developmental morphogenesis and neural connectivity, spanning multiple tissues and models, indicating a broad developmental function rather than a single, specific pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070168","count":1},{"id":"GO:0001658","count":1},{"id":"GO:0001657","count":1},{"id":"GO:0035754","count":1},{"id":"GO:0021836","count":1}]},{"hash":"2124462834282305660","title":"Unknown","description":"The top GO terms are highly diverse: neural development (forebrain development, neural tube closure), multicellular development, transcription, cell cycle, and ER-stress\u2013associated apoptosis, but also cadmium response and defense against Gram-positive bacteria. This broad and scattered set lacks a single coherent function or pathway defining the cluster, so a specific label isn\u2019t supported. ","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071276","count":3},{"id":"GO:0001403","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0006349","count":3}]},{"hash":"1189072926031881379","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032471","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0051561","count":2},{"id":"GO:0008360","count":1}]},{"hash":"2007098118301638811","title":"Redox-regulated metabolism","description":"The top GO terms cluster around redox balance and metabolic pathways: pentose phosphate shunt and pentose biosynthesis, negative regulation of reactive oxygen species metabolism, and negative regulation of protein glutathionylation, plus iron response and cholesterol biosynthesis. While there are also terms related to immune and neuronal processes, the predominant pattern ties to redox control and metabolic flux, suggesting a cluster of proteins involved in maintaining cellular redox state and metabolic regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043029","count":2},{"id":"GO:0010734","count":1},{"id":"GO:2000378","count":1},{"id":"GO:0006098","count":1},{"id":"GO:0019322","count":1}]},{"hash":"2162135068947168408","title":"P-body Mediated mRNA Decay and miRNA Silencing","description":"The top GO terms cluster around P-body assembly and canonical mRNA decay pathways\u2014deadenylation, decapping, and exonucleolytic decay\u2014as well as miRNA-mediated post-transcriptional gene silencing. This points to a coherent theme of cytoplasmic mRNA turnover and regulation within P-bodies, with a secondary note of transcriptional regulation terms that may reflect multifunctional proteins rather than core cluster function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033962","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0043928","count":2},{"id":"GO:0000289","count":2},{"id":"GO:0000288","count":2}]},{"hash":"2257504597314523191","title":"Developmental signaling and cell adhesion","description":"The GO terms point to developmental processes (heart development, angiogenesis, ovulation cycle) together with adhesion-related activities (calcium-independent cell-matrix adhesion, substrate adhesion-dependent cell spreading, potassium channel clustering) and signaling pathways (MAPK regulation, RhoGEF activity). This suggests a cluster of proteins involved in coordinating signaling with adhesion during development and tissue remodeling, including neuronal migration cues. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2001108","count":3},{"id":"GO:0007161","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0021836","count":3},{"id":"GO:0045163","count":3}]},{"hash":"825084255676226249","title":"Nuclear RNA processing and transcription regulation","description":"This cluster centers on RNA metabolism and transcriptional control in the nucleus, with terms spanning splicing (spliceosomal snRNP/complex assembly), RNA processing (tRNA processing), transcription termination, and nuclear mRNA decapping/import. The presence of P-body assembly hints at broader RNA decay, while chromatin-related term and ABA/water deprivation responses suggest links to transcriptional regulation during stress. Overall, a nucleus-centric RNA processing and transcription regulation theme fits best.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0033962","count":4},{"id":"GO:0009414","count":4},{"id":"GO:0000387","count":4},{"id":"GO:0006369","count":4},{"id":"GO:1990141","count":4}]},{"hash":"947009806564583102","title":"Chaperone-mediated folding and quality control","description":"The top GO terms are dominated by chaperone-related processes: chaperone-mediated protein complex assembly, chaperone-dependent/refolding, and detection of misfolded proteins, plus a heat-stress response. Although a few other terms (scaRNA localization, pore complex assembly, host-cell translocation) appear, the core signal points to proteostasis and stress-associated protein folding managed by chaperones. Confidence: High","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051131","count":4},{"id":"GO:0051086","count":4},{"id":"GO:0090666","count":4},{"id":"GO:0046931","count":4},{"id":"GO:0051085","count":4}]},{"hash":"388012252228093036","title":"Neuronal synaptic transmission and vesicle trafficking","description":"The cluster shows prominent terms related to neuronal synapse function, including evoked neurotransmitter secretion and maintenance of presynaptic active zone structure, as well as auditory receptor cell morphogenesis, and COPII-coated vesicle budding reflecting secretory pathway activity. While a couple of terms like rRNA processing and cell cycle checkpoints are generic, the converging signals point to a neural presynaptic/vesicular trafficking theme, justifying a label focused on neuronal synaptic transmission and vesicle trafficking.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006364","count":2},{"id":"GO:0035900","count":2},{"id":"GO:0010963","count":1},{"id":"GO:0002093","count":1},{"id":"GO:0031578","count":1}]},{"hash":"1368853991727521891","title":"Ubiquitin-dependent proteolysis and cell cycle regulation","description":"The top GO terms center on ubiquitination and proteasomal protein degradation (ubiquitin-dependent protein catabolic process, SCF-dependent proteasomal ubiquitin-dependent degradation), with supporting deubiquitination terms and links to meiotic cell cycle transitions and sister chromatid movement, suggesting a cluster of proteins coordinated for protein turnover to control meiosis and the cell cycle.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035518","count":2},{"id":"GO:0016567","count":2},{"id":"GO:1902104","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0051759","count":2}]},{"hash":"2162813723744561962","title":"Caveolin-mediated endocytosis and lipid signaling","description":"The strongest signal in the set is caveolin-mediated endocytosis (GO:0072584) with four proteins, and there are several lipid-related terms (regulation of sphingolipid biosynthesis, membrane processes) pointing to membrane trafficking and lipid signaling. Some outlier terms (neuron development, centrosome cycle) may reflect pleiotropic roles of the included proteins, but the dominant theme centers on caveolae-associated endocytosis and lipid signaling.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0072584","count":4},{"id":"GO:0033598","count":4},{"id":"GO:1990804","count":4},{"id":"GO:0007098","count":4},{"id":"GO:0043506","count":4}]},{"hash":"1710803135939094718","title":"Multisystem Signaling and Development Proteins","description":"The top GO terms cover insulin signaling, neural development (cerebellar cortex formation, Bergmann glial differentiation, axon regeneration), immune signaling (T cell receptor), and endocytosis, suggesting these proteins participate in diverse signaling and developmental roles across tissues rather than a single pathway. This broad, cross-system theme justifies a label of multisystem signaling and development.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":3},{"id":"GO:0021697","count":3},{"id":"GO:0060020","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0008285","count":3}]},{"hash":"688289514656763410","title":"Stimulus-Response Signaling and Sensory Processing","description":"The GO terms point to a common theme of signal transduction and downstream responses to diverse stimuli (glucose, dsRNA, cocaine) alongside sensory and neural processing (pain, visual perception/learning) and pathways like ERK cascade and protein phosphorylation. Although heart development appears, the overarching connection is stimulus-driven signaling and sensory-response mechanisms.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":3},{"id":"GO:0043330","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0048148","count":2}]},{"hash":"730614038263856574","title":"Arabinogalactan protein glycosylation and cell-wall biosynthesis","description":"The cluster\u2019s top GO terms cluster around plant glycoprotein modification and cell-wall biosynthesis, especially hydroxyproline-rich protein O-linked glycosylation, arabinogalactan protein metabolism, and seed coat/mucilage polysaccharide biosynthesis. This points to a coherent theme of AGP-related extracellular matrix formation, though a few terms (Notch signaling, B cell differentiation) appear as outliers rather than representative functions.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0018258","count":2},{"id":"GO:0075015","count":2},{"id":"GO:0010493","count":2},{"id":"GO:0001744","count":2},{"id":"GO:0030311","count":2}]},{"hash":"498651650299701875","title":"Bacterial cell wall glycan biosynthesis","description":"This cluster shows GO terms centered on synthesis of cell wall polysaccharides and related glycosylation processes (teichoic acid biosynthesis, cellulose biosynthesis, glycan modifications), indicating proteins that participate in constructing or modifying the bacterial cell envelope.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019350","count":1},{"id":"GO:0002378","count":1},{"id":"GO:0018242","count":1},{"id":"GO:0030213","count":1},{"id":"GO:0018243","count":1}]},{"hash":"1349929177107543609","title":"RNA and protein methylation","description":"The top GO terms cluster around methylation activities, including tRNA and rRNA methylation, RNA cap methylation (7-methylguanosine), and various peptide methylations, indicating a cohesive function in methyltransferase-related modifications of both RNA and proteins. This makes \"RNA and protein methylation\" a concise, representative label.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030488","count":2},{"id":"GO:0009236","count":2},{"id":"GO:1901052","count":2},{"id":"GO:0031167","count":2},{"id":"GO:0002098","count":2}]},{"hash":"1294183162899401291","title":"Fertilization-linked Centrosome and Cell-Cycle Regulation","description":"These terms cluster around centrosome cycle/duplication, regulation of the cell cycle (especially G2/M), and fertilization-related events such as sperm DNA decondensation and single fertilization, suggesting a common theme of coordination between fertilization processes and centrosome/cell-cycle control.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0044387","count":1},{"id":"GO:0007098","count":1},{"id":"GO:0007338","count":1},{"id":"GO:0006407","count":1},{"id":"GO:0060699","count":1}]},{"hash":"185885062890908484","title":"Membrane signaling and cytoskeletal remodeling","description":"Proteins in this cluster point to membrane-associated signaling and dynamic cytoskeletal changes: responses to growth factors and hormones (TGF-\u03b2, NGF, cholecystokinin), endocytosis via caveolin-mediated pathways, actin crosslinking, and engulfment of apoptotic cells. The shared theme is signaling events at the membrane that drive cytoskeletal remodeling and trafficking, rather than a single enzymatic activity.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035156","count":2},{"id":"GO:0014911","count":2},{"id":"GO:0061847","count":2},{"id":"GO:0009395","count":2},{"id":"GO:0071560","count":2}]},{"hash":"440670523439414167","title":"Unknown","description":"There are no GO terms or interactions listed for this cluster (Edges: 0, Triangles: 0), so there is no coherent functional signal to define a shared label.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1652311022491107183","title":"Developmental and neural signaling","description":"This cluster centers on developmental processes such as heart and multicellular organism development and myoblast fusion, alongside neuronal signaling terms like excitatory postsynaptic potential and long-term potentiation, suggesting proteins that participate in development and synaptic function. Additional terms touch on regulation of phosphorylation, apoptosis, and cell-cycle progression, indicating a broader role in signaling and growth control during development.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0014044","count":2},{"id":"GO:0010800","count":2},{"id":"GO:0007520","count":2},{"id":"GO:0043065","count":2}]},{"hash":"1886716920993972456","title":"Cardiovascular and neural development signaling","description":"The top GO terms cluster around heart development, angiogenesis, and blood coagulation, with additional signals related to MAPK cascade regulation, cell-matrix adhesion, Kv channel clustering, and neural migration. Together these terms point to overarching developmental signaling processes that influence cardiovascular formation and neural development.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:2001108","count":3},{"id":"GO:0007161","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0021836","count":3}]},{"hash":"133275844435747081","title":"Leukocyte migration and integrin signaling","description":"The terms center on leukocyte chemotaxis (T cells, eosinophils, lymphocytes) and integrin-mediated signaling, suggesting a module coordinating immune cell adhesion/movement, with supporting PKC signaling; the combination points to a cohesive leukocyte migration/adherence function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":3},{"id":"GO:0051088","count":2},{"id":"GO:0035625","count":2},{"id":"GO:0070528","count":2},{"id":"GO:0007338","count":2}]},{"hash":"273338776743535606","title":"Endothelial Adhesion and Barrier Regulation","description":"The top GO terms cluster around adhesion and vascular barrier functions, including positive regulation of establishment of the endothelial barrier, heterophilic cell-cell adhesion, and calcium-independent cell-matrix adhesion, along with leukocyte tethering. Additional terms touch on junction assembly and coagulation-related processes, which together suggest a role in endothelial interaction and barrier integrity. Some terms (e.g., synapse maturation, LPS response) are less directly tied but may reflect broader cellular activation contexts; overall the common theme is adhesion-driven regulation of endothelial barriers.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903142","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0050901","count":1},{"id":"GO:0060074","count":1},{"id":"GO:0007161","count":1}]},{"hash":"2105441460046432521","title":"Transsulfuration and Cysteine Biosynthesis","description":"The dominant GO terms center on cysteine production via L-cystathionine and the transsulfuration pathway, with related amino-acid biosynthesis steps (L-threonine, 2-oxobutyrate). Although stress-response terms appear, the core signal is sulfur-containing amino acid metabolism, implying these proteins participate in cysteine biosynthesis and transsulfuration.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042542","count":2},{"id":"GO:0009749","count":2},{"id":"GO:0019343","count":1},{"id":"GO:0043278","count":1},{"id":"GO:0009088","count":1}]},{"hash":"1620095967756786196","title":"Mitotic growth and ER-Golgi vesicle trafficking","description":"The top GO terms cluster around ribosome biogenesis and cell proliferation (mitosis), alongside ER-to-Golgi vesicle transport and COPII vesicle budding, indicating a theme of supporting protein synthesis and membrane trafficking during cell division. Additional terms related to brain development and multicellular growth align with broader growth processes but still fit the overarching growth/division context. Therefore, the label captures the core function of this cluster: mitotic growth coupled with secretory pathway trafficking. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0008283","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0090114","count":2},{"id":"GO:0000747","count":2}]},{"hash":"1486685515915622084","title":"Neural development and axon\u2013synapse organization","description":"The cluster is enriched for neural development terms, including interneuron migration, paranodal and juxtaparanodal axon organization, protein localization to nodes of Ranvier, and synapse assembly, along with cell\u2013cell adhesion. While a few terms touch on skeletal ossification, the dominant signal centers on neural development and axon\u2013synapse organization, suggesting these proteins function in neural patterning, myelinated axon domain organization, and synapse formation.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0021836","count":4},{"id":"GO:0071205","count":4},{"id":"GO:0051965","count":4}]},{"hash":"1809209524988502407","title":"Synaptic Vesicle Release and Plasticity","description":"This cluster centers on synaptic function, with terms for neurotransmitter secretion/transport, synaptic vesicle exocytosis, and positive regulation of synaptic plasticity, plus calcium homeostasis that supports release dynamics and spine maintenance. The core theme is regulated neuronal communication and plastic changes at the synapse.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046928","count":2},{"id":"GO:0006836","count":2},{"id":"GO:0031915","count":2},{"id":"GO:0016079","count":2},{"id":"GO:0030073","count":2}]},{"hash":"390000187012003582","title":"Embryonic and Organ Development","description":"The dominant terms describe development across multiple tissues (brain, endocardial cushion EMT, placenta, cartilage, pancreas, endocrine system). A ubiquitin-dependent proteolysis term suggests general protein turnover regulation during development. Overall, the cluster reflects broad developmental and morphogenetic programs rather than a single specific pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0003198","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0060536","count":1}]},{"hash":"1581199075317707834","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0044205","count":1},{"id":"GO:0045982","count":1},{"id":"GO:0032265","count":1},{"id":"GO:0006207","count":1},{"id":"GO:0046101","count":1}]},{"hash":"1637678744271306908","title":"Glycosylation and cell wall biosynthesis","description":"The top GO terms cluster around glycan-related biosynthesis and cell envelope components: dolichol-linked oligosaccharide biosynthesis, lipid glycosylation, peptidoglycan biosynthetic process, and lipoteichoic acid biosynthetic process, along with related cell shape regulation and division. Although several plant flavonoid biosynthesis terms appear, the dominant signal points to glycosylation pathways and cell wall assembly in these proteins, making this a cohesive cluster for glycan biosynthesis and envelope formation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0008360","count":3},{"id":"GO:0033330","count":3},{"id":"GO:0070395","count":3},{"id":"GO:0070980","count":3},{"id":"GO:0009718","count":3}]},{"hash":"777764879174745919","title":"APC/C-Mediated Mitosis Regulation","description":"The top GO terms strongly point to ubiquitin-proteasome\u2013driven control of mitosis, including APC/C-dependent catabolic processes and protein autoubiquitination, plus proteasome localization related to mitotic regulation. This suggests a theme of regulated protein degradation governing spindle checkpoint dynamics and cell-cycle progression, with other terms like JNK cascade and DNA damage tolerance representing broader stress-response connections; however, the core signal is ubiquitin-mediated mitotic control.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1902426","count":4},{"id":"GO:0001701","count":4},{"id":"GO:0010976","count":4},{"id":"GO:1990920","count":4},{"id":"GO:0051569","count":4}]},{"hash":"514617754273543528","title":"Ubiquitin-Mediated Innate Antiviral Defense","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes, various forms of ubiquitination (including K63-linked), and innate immune/defense responses to virus, pointing to a theme of tagging and degrading proteins as part of antiviral innate immunity. While a few terms (e.g., formaldehyde catabolic process, heterochromatin formation) seem unrelated, they are less represented and likely noise. Overall, the proteins likely participate in ubiquitin-mediated proteolysis in antiviral defense.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0051607","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0070301","count":2}]},{"hash":"1845143150455212825","title":"Embryogenesis and Organ Morphogenesis","description":"This cluster is dominated by GO terms tied to embryonic development and organ formation across multiple lineages (gastrulation-related primitive streak formation, neural crest migration, peripheral nervous system development, pancreas and digestive tract development, ureteric bud branching, etc.). The terms point to a broad developmental theme rather than a single pathway, suggesting proteins involved in lineage specification and morphogenesis. Confidence reflects a coherent developmental theme, though the diverse terms reduce the specificity to one exact process.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:1902262","count":3},{"id":"GO:0035019","count":3},{"id":"GO:0048935","count":3},{"id":"GO:0090009","count":3}]},{"hash":"1755210078514497782","title":"Notch-driven keratinocyte differentiation and immune signaling","description":"Notch receptor processing and keratinocyte differentiation point to a Notch-regulated epidermal differentiation theme. The accompanying terms such as response to tumor necrosis factor, monocyte activation, and lymphocyte chemotaxis suggest immune/inflammatory activity that can intersect skin biology. Together, they imply a cluster capturing Notch-associated epidermal development with broader immune signaling, rather than a single cohesive pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007220","count":3},{"id":"GO:0010042","count":3},{"id":"GO:0030216","count":3},{"id":"GO:0034612","count":3},{"id":"GO:0007161","count":2}]},{"hash":"1943931839485304517","title":"Plant peroxisomal lipid metabolism and photomorphogenesis","description":"The top GO terms cluster around peroxisomal function and fatty acid metabolism, including very long-chain fatty acid metabolic process, protein import into peroxisome matrix, and peroxisome-chloroplast membrane tethering, as well as photomorphogenesis, which together suggest a plant-specific peroxisomal role in lipid metabolism linked to light responses. Some unrelated terms (meiosis/spermatocyte division, ubiquitination) imply annotation noise or mixed functions, but the strongest cohesive theme points to peroxisomal lipid metabolism and photomorphogenesis in plants.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007112","count":1},{"id":"GO:0048137","count":1},{"id":"GO:0031648","count":1},{"id":"GO:0000038","count":1},{"id":"GO:0007285","count":1}]},{"hash":"333752992433685451","title":"Apoptosis and T-cell Regulation","description":"The top GO terms point strongly to programmed cell death and immune signaling: execution phase of apoptosis, apoptotic nuclear changes, DNA damage checkpoint signaling, TNF response, and T-cell differentiation/regulation (negative regulation of activation-induced cell death). A few terms about membrane dynamics and myoblast fusion are more peripheral but may reflect shared membrane remodeling contexts in apoptotic or immune pathways. Overall, the cluster centers on apoptosis-related pathways and T-cell regulatory processes.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097194","count":2},{"id":"GO:1903527","count":2},{"id":"GO:0046325","count":1},{"id":"GO:0033077","count":1},{"id":"GO:0070236","count":1}]},{"hash":"720993118162762825","title":"Interleukin signaling cluster","description":"This cluster's top GO terms are dominated by interleukin-mediated signaling pathways (IL-5, IL-7, IL-11, IL-27) and related cytokine signaling, along with regulatory processes like mast cell degranulation and astrocyte differentiation, pointing to a cohesive theme of cytokine-driven immune signaling rather than a single structural function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043305","count":1},{"id":"GO:0038111","count":1},{"id":"GO:0032674","count":1},{"id":"GO:0048661","count":1},{"id":"GO:0042517","count":1}]},{"hash":"1721466016707708694","title":"Organ and sensory system development","description":"The terms are dominated by development across multiple tissues, including nervous system, retina, heart, and lung, with sensory perception of sound also present. While there are a few outliers (spliceosome regulation, immune-related terms), the overall pattern points to broad organ/sensory system development rather than a single molecular function, justifying this label.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0043311","count":1},{"id":"GO:0060427","count":1}]},{"hash":"2131862661331258217","title":"Cell signaling and endocytosis with cytoskeleton dynamics","description":"The terms cluster around signaling pathways (JUN phosphorylation; insulin receptor and PDGF signaling) and cytoskeletal remodeling (actin crosslinking, cell spreading) with membrane trafficking activities (caveolin-mediated endocytosis, transcytosis). Development-related terms (heart development, NK T cell differentiation) appear in the same functional landscape, suggesting a theme of signaling coordinating cytoskeleton and endocytosis across contexts.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007258","count":4},{"id":"GO:0051764","count":3},{"id":"GO:0072584","count":3},{"id":"GO:0001865","count":3},{"id":"GO:0007507","count":3}]},{"hash":"474545375051447816","title":"Lipid-linked glycosylation and phospholipid metabolism","description":"The top terms cluster around lipid-linked protein glycosylation (GPI anchor biosynthesis; dolichol-related glycosylation) and lipid/phospholipid metabolism (phospholipid biosynthesis/dephosphorylation, sphinganine-1-phosphate metabolism, phosphatidylglycerol biosynthesis). While a detoxification term appears, the dominant theme ties glycosylation to lipid metabolism, suggesting a cohesive function in lipid-linked protein modification. ","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":2},{"id":"GO:0006506","count":1},{"id":"GO:0035269","count":1},{"id":"GO:0019348","count":1},{"id":"GO:0009395","count":1}]},{"hash":"2221615065588000521","title":"Cardiac muscle contraction and vascular regulation","description":"Top GO terms indicate heart muscle function (cardiac muscle contraction, sarcomere organization, regulation of heart rate by epinephrine) and vascular remodeling (negative regulation of angiogenesis and vascular smooth muscle cell migration/proliferation), suggesting proteins in this cluster contribute to cardiac activity and vascular dynamics; a single outlier term (spicule insertion) appears incidental.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":2},{"id":"GO:0003065","count":2},{"id":"GO:1904753","count":2},{"id":"GO:0034609","count":2},{"id":"GO:1904706","count":2}]},{"hash":"1115219015811247271","title":"Coagulation and Fibrinolysis Regulation","description":"The cluster is dominated by terms related to hemostasis, including blood coagulation, fibrinolysis, and negative regulation of plasminogen activation, plus related ECM secretion, pointing to regulation of clot formation and breakdown rather than other pathways.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003331","count":4},{"id":"GO:0051918","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0042730","count":4},{"id":"GO:0010757","count":4}]},{"hash":"852182623737191575","title":"Oxidative metabolism of small molecules and xenobiotics","description":"The top GO terms point to multiple small-molecule oxidation and catabolic processes (ethanol, galactose, retinol, fatty acids, aldehydes) and related detoxification activities, along with some stress response terms. This suggests a cohesive theme of enzymatic oxidation and breakdown of diverse substrates, rather than a single specific pathway; despite the small size and lack of edges, the cluster appears to reflect a detoxification/metabolism module.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019518","count":2},{"id":"GO:0006069","count":2},{"id":"GO:0033498","count":2},{"id":"GO:0006068","count":2},{"id":"GO:0032496","count":2}]},{"hash":"1185744090094240991","title":"Fungal sterol and lipid biosynthesis","description":"The top GO terms cluster around lipid and sterol metabolism, including unsaturated fatty acid biosynthesis, ergosterol biosynthesis regulation, and sphingolipid metabolism (mannosyl-inositol phosphorylceramide), which are characteristic of fungal lipid pathways. Some terms are peripheral (e.g., nitrate assimilation, nitric oxide biosynthesis, and unrelated tissue differentiation ontologies), but the dominant theme points to sterol and lipid biosynthesis in fungi. Confidence: Medium.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":3},{"id":"GO:0032286","count":3},{"id":"GO:0006636","count":3},{"id":"GO:0006675","count":3},{"id":"GO:0032443","count":3}]},{"hash":"742970495662391982","title":"Antigen presentation and innate immune activation","description":"This cluster\u2019s top GO terms cluster around MHC class I\u2013restricted antigen processing/presentation, innate immune signaling, phagocytosis enhancement, and dendritic cell migration, all pointing to a theme of initiating and modulating immune responses. While a few terms touch on development or other processes, the dominant terms suggest a common function in antigen presentation and innate immune activation, with supporting roles in cell adhesion and migration of immune cells.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"protein folding","top_go_terms":[{"id":"GO:0002502","count":3},{"id":"GO:0071157","count":3},{"id":"GO:1900026","count":3},{"id":"GO:1901224","count":3},{"id":"GO:0048916","count":3}]},{"hash":"1161881572362717906","title":"mRNA Splicing and Processing Regulation","description":"The top GO terms cluster around spliceosome-mediated mRNA splicing, mRNA export, stability, and regulatory interactions with ncRNA, indicating a shared role in mRNA maturation and post-transcriptional control rather than a single catalytic activity. This theme fits the combination of splice site recognition, cis-splicing, export, and stability regulation observed in the terms.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0010610","count":3},{"id":"GO:0048255","count":3},{"id":"GO:0006376","count":3}]},{"hash":"1452763055913740676","title":"Neural morphogenesis and vesicle trafficking","description":"The terms center on auditory receptor morphogenesis and nerve branching, plus evoked neurotransmitter secretion and assorted endosome transport steps, indicating a theme of neural development linked to vesicle trafficking. This coherence suggests the proteins jointly contribute to neural structure formation and synaptic/endosomal pathways rather than unrelated processes.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0002093","count":3},{"id":"GO:0031578","count":3},{"id":"GO:0061670","count":3},{"id":"GO:0051489","count":3},{"id":"GO:2000172","count":3}]},{"hash":"1103519774871075969","title":"Neural and muscle development with lipid-calcium signaling","description":"This cluster is enriched for neural and vascular development (brain development, angiogenesis) and muscle differentiation (myoblast fusion), together with calcium signaling (activation of store-operated calcium channels) and lipid metabolism (phospholipid catabolism, sphingolipid biosynthesis). This combination points to a developmental program in which calcium and lipid signaling coordinate neural and muscular growth.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0009395","count":2},{"id":"GO:1900087","count":2},{"id":"GO:0050859","count":2},{"id":"GO:0051282","count":2}]},{"hash":"298972113032161370","title":"Sterol and isoprenoid biosynthesis","description":"The cluster\u2019s prominent GO terms center on sterol and isoprenoid production (cholesterol/ergosterol biosynthesis, farnesyl diphosphate biosynthesis via the mevalonate pathway) and related acetyl-CoA metabolism, indicating a coordinated role in lipid/terpenoid biosynthesis and associated energy metabolism, with a few outliers that may reflect broader secondary metabolism or regulatory processes.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006695","count":2},{"id":"GO:0006084","count":2},{"id":"GO:0010142","count":2},{"id":"GO:0006696","count":2},{"id":"GO:0070317","count":2}]},{"hash":"950370658207657399","title":"Small-molecule oxidation metabolism","description":"These proteins show a cluster of GO terms tied to oxidation-based catabolism of diverse small molecules\u2014ethanol oxidation, galactose catabolism via D-galactonate, fatty acid omega-oxidation, retinol metabolism, and furaldehyde metabolism\u2014along with occasional stress-response terms (copper ion and nitrosative stress). The overall theme is metabolism of small molecules through oxidative processes, though there are no reported network edges, so the label reflects shared functional annotations rather than connectivity. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0019518","count":3},{"id":"GO:0006069","count":3},{"id":"GO:0033498","count":3},{"id":"GO:0006068","count":3},{"id":"GO:0032496","count":3}]},{"hash":"581892901529043731","title":"Cilium assembly and intraciliary transport","description":"The cluster is dominated by GO terms related to ciliogenesis and intraciliary transport, including intraciliary transport involved in cilium assembly, motile and non-motile cilium assembly, and intraciliary retrograde transport. These suggest the proteins collaborate in building and trafficking within cilia. A few developmental terms (neurogenesis, imaginal disc-derived wing morphogenesis) may reflect broader roles of ciliary pathways in development, but the core signal clearly centers on ciliogenesis and ciliary trafficking.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0022008","count":2},{"id":"GO:1900740","count":2},{"id":"GO:0051292","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0007476","count":2}]},{"hash":"51588166464515727","title":"Autophagy and vesicle trafficking regulation","description":"The cluster\u2019s top GO terms center on autophagy (mitophagy, aggrephagy) and vesicle trafficking control (negative regulation of clathrin-mediated endocytosis, intralumenal vesicle formation). This suggests a shared role in protein turnover and vesicle dynamics, despite some outlier terms such as ribosomal assembly or nucleotide-excision repair. Confidence: Medium","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1905366","count":3},{"id":"GO:1904378","count":3},{"id":"GO:0017085","count":3},{"id":"GO:1900186","count":3},{"id":"GO:0016925","count":3}]},{"hash":"842426709815792936","title":"Fungal defense and autophagy with protein modification","description":"The top GO terms cluster around defense response to fungus, macroautophagy/nucleophagy, and various protein-modification processes (sumoylation, neddylation, lipidation). This combination suggests a cohesive fungal stress-response module where autophagy is coordinated with post-translational modifications to regulate growth, defense, and metabolism. Some terms (e.g., thiamine biosynthesis) are peripheral but do not override the main theme.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050832","count":2},{"id":"GO:0045116","count":2},{"id":"GO:2000220","count":2},{"id":"GO:0016925","count":2},{"id":"GO:0006501","count":2}]},{"hash":"470135525754966673","title":"Protein modification and innate immune signaling","description":"The top GO terms cluster around post-translational modifications (sumoylation, neddylation, lipidation) and regulation of immune pathways (MyD88-dependent TLR signaling, defense against fungus), suggesting a group of proteins involved in PTMs that modulate innate immunity; a few terms are less cohesive (tRNA modification, hippocampus development), but the core theme points to PTMs coordinating immune responses.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002143","count":3},{"id":"GO:0032447","count":3},{"id":"GO:0050832","count":2},{"id":"GO:0045116","count":2},{"id":"GO:0034126","count":2}]},{"hash":"767723626977817341","title":"NF-kappaB\u2013driven calcium signaling in heart and brain","description":"The GO terms center on innate immune response and NF-kappaB regulation, with several calcium- and development-related terms connected to cardiac function (calcium release, heart rate, heart development) and neural/glial activity (astrocyte activation, hypoxia response). This suggests a theme where inflammatory NF-kappaB signaling intersects with calcium-dependent pathways impacting heart and brain development and stress responses. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0010881","count":1},{"id":"GO:0002027","count":1}]},{"hash":"1267673225219321169","title":"Organelle trafficking and energy metabolism","description":"This cluster connects to intracellular protein handling and organelle function (peroxisome import, Golgi retention, ER polarization, endosomal microautophagy) and core energy processes (oxidative phosphorylation, aerobic respiration, CoA biosynthesis, FAD catabolism), suggesting a theme of coordinating protein trafficking with metabolic regulation.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0072389","count":2},{"id":"GO:0051131","count":2},{"id":"GO:0016562","count":2},{"id":"GO:1903862","count":2},{"id":"GO:0032968","count":2}]},{"hash":"2116091411191371443","title":"RNA processing and ribosome biogenesis","description":"This cluster is enriched for GO terms tied to RNA processing (mRNA splicing, stability regulation) and ribosome biogenesis/translation (ribosome biogenesis, translation, small subunit biogenesis), with mitochondrial mRNA polyadenylation also present. The common theme points to RNA maturation and the protein synthesis machinery across nuclear and mitochondrial contexts.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0097222","count":2},{"id":"GO:0042274","count":2},{"id":"GO:0010610","count":2}]},{"hash":"29819853904755078","title":"DNA replication, repair, and transformation competence","description":"The proteins cluster around DNA metabolism: DNA replication, repair, and recombination, along with plasmid maintenance and transformation competence, suggesting a DNA-processing module involved in genetic material handling and uptake.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030420","count":1},{"id":"GO:0051096","count":1},{"id":"GO:0070584","count":1},{"id":"GO:0006269","count":1},{"id":"GO:0006276","count":1}]},{"hash":"2219890474325137407","title":"Brush border microvilli formation and actin remodeling","description":"This cluster is dominated by GO terms tied to intestinal brush border structure and actin-based cytoskeleton organization, including focal adhesion assembly, terminal web assembly, regulation of microvillus length, and intestinal glucose absorption. These point to microvilli formation and actin dynamics in epithelial cells, with some peripheral terms (JAK, G1/S) likely reflecting broader signaling contexts rather than core function. ","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048041","count":2},{"id":"GO:0031532","count":2},{"id":"GO:1902896","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0001951","count":2}]},{"hash":"566683581070324350","title":"Developmental morphogenesis and stress signaling","description":"The top GO terms cluster around tissue development in multiple organs (spinal cord, skin, retina) and morphogenesis, while also highlighting signaling and stress responses (TGF-beta signaling, hypoxia, TORC1 regulation) and cytoskeletal remodeling (Arp2/3). This suggests a compact module of proteins involved in developmental growth and adaptation to environmental cues, rather than a single, specific pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021510","count":3},{"id":"GO:0071560","count":3},{"id":"GO:0071276","count":3},{"id":"GO:1904263","count":3},{"id":"GO:0034316","count":3}]},{"hash":"1851529649522592167","title":"Autophagy- and ubiquitin-regulated trafficking","description":"The GO terms point to autophagy/mitophagy (type 2 mitophagy, engulfment of target by autophagosome) and ubiquitin signaling (K29-linked ubiquitination, deubiquitination regulation), as well as trafficking-related processes (endosome size regulation, kinetochore localization). These intersect at cellular quality control and intracellular transport, suggesting a module where autophagy and ubiquitin-mediated regulation coordinate trafficking and organelle turnover. ","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0006547","count":2},{"id":"GO:0061734","count":2},{"id":"GO:0035519","count":2},{"id":"GO:0010793","count":2}]},{"hash":"1440254428601109482","title":"TGF-beta and MAPK Signaling Regulation","description":"The terms point to modulation of signaling pathways, especially TGF-beta signaling (cellular response to TGF-beta stimulus and negative regulation of TGF-beta receptor signaling) and MAPK cascade activity, along with related phosphatase activity. Although there are some divergent terms (e.g., meristem identity maintenance, germline masculinization), the strongest recurring theme is regulation of growth factor\u2013related signaling pathways, justifying a label focused on TGF-beta and MAPK signaling regulation.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":1},{"id":"GO:0000173","count":1},{"id":"GO:0035970","count":1},{"id":"GO:0010074","count":1},{"id":"GO:0030512","count":1}]},{"hash":"232397135909597864","title":"Chromatin Regulation and TNF-NF-\u03baB Signaling","description":"The cluster\u2019s terms cluster around chromatin modulation (histone methylation/acetylation, histone ubiquitination, X chromosome inactivation) and immune/stress signaling (TNF-mediated signaling and NF-kappaB activation), plus ubiquitin-related regulation, suggesting proteins that link chromatin state to transcriptional responses and signaling pathways.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046621","count":3},{"id":"GO:0070512","count":3},{"id":"GO:0042981","count":3},{"id":"GO:0070535","count":3},{"id":"GO:2000620","count":3}]},{"hash":"2192780759730373726","title":"Cell Stress and DNA Damage Response","description":"The terms converge on cellular responses to stress: oxidative signals (response to hydrogen peroxide), xenobiotic response, DNA catabolic process, and apoptotic pathways, indicating a stress-induced DNA damage signaling theme. Some terms related to renal water transport and smooth muscle migration appear but are not clearly connected to this core, suggesting incidental annotations.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0014912","count":1},{"id":"GO:2001153","count":1},{"id":"GO:0006308","count":1},{"id":"GO:1900087","count":1},{"id":"GO:0080111","count":1}]},{"hash":"1392435351700506578","title":"Unknown","description":"The terms span muscle and cartilage development, left-right patterning, and immune processes (germinal centers, memory T cells, type 2 response), plus an ubiquitin-dependent protein catabolic process and an obsolete term. There isn't a single cohesive function linking all terms, so no clear cluster theme emerges.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:1900477","count":2},{"id":"GO:0045497","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0060536","count":2}]},{"hash":"1169402536985812097","title":"Cardiac cAMP/cGMP Signaling","description":"The top GO terms point to heart-related regulation (regulation of heart rate, cardiac muscle cell proliferation) and modulation of second messenger pathways (positive regulation of adenylate cyclase, negative regulation of cAMP-dependent PKA, cellular response to cGMP, regulation of membrane potential). While some terms (like olfactory perception and bud neck localization) are less aligned, the strongest signal is cardiac signaling via cAMP/cGMP pathways, supporting a label focused on cardiac second messenger signaling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0002027","count":1},{"id":"GO:0007608","count":1},{"id":"GO:0097271","count":1},{"id":"GO:0042391","count":1}]},{"hash":"1213386912992230289","title":"Mitotic DNA Replication Machinery","description":"The top GO terms are dominated by mitotic DNA replication processes, including initiation, preinitiation complex assembly, and GINS complex assembly, pointing to proteins involved in the CMG helicase\u2013mediated replication during mitosis. A few terms about dendritic spine morphogenesis or inner cell mass proliferation seem incidental or related to pleiotropic roles, but the core signal centers on replication initiation and elongation in mitosis. Confidence in this functional grouping is High.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902983","count":1},{"id":"GO:0001833","count":1},{"id":"GO:0000727","count":1},{"id":"GO:1902977","count":1},{"id":"GO:1902975","count":1}]},{"hash":"2076006519709181274","title":"Intracellular Energy Metabolism and Organelle Trafficking","description":"The top GO terms show energy-related processes (positive regulation of oxidative phosphorylation, regulation of aerobic respiration) together with various organelle-focused trafficking and maintenance activities (peroxisome matrix import, Golgi retention, ER polarization) and endosomal/autophagic processes, plus signaling (response to cAMP) and transcriptional elongation. This suggests a broad theme where cellular energy status interfaces with protein trafficking and organelle maintenance, rather than a single tightly cohesive function, making this label a concise representation of the cluster\u2019s overarching focus. ","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051591","count":2},{"id":"GO:0072389","count":1},{"id":"GO:0051131","count":1},{"id":"GO:0016562","count":1},{"id":"GO:1903862","count":1}]},{"hash":"922213815814298224","title":"Germ Cell Development and Meiosis","description":"The GO terms cluster around germline development and meiosis (female meiosis chromosome segregation, spermatogenesis, oocyte growth, germ-line stem cell maintenance, germ cell migration, and meiotic nuclear division regulation), with additional posts-transcriptional regulation of mRNA; one outlier term (cerebellar neuron development) likely incidental.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016321","count":1},{"id":"GO:0045886","count":1},{"id":"GO:0007283","count":1},{"id":"GO:0017148","count":1},{"id":"GO:0036099","count":1}]},{"hash":"1181039747398092548","title":"Plastid ribosome biogenesis","description":"The cluster centers on ribosome biogenesis and subunit assembly (GO:0042254, GO:0042274) and includes protein targeting to chloroplast (GO:0045036), suggesting nucleus-encoded ribosomal components destined for plastids and involved in chloroplast ribosome assembly. Confidence: High","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0045036","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0042274","count":2}]},{"hash":"2242454418745746169","title":"Microtubule nucleation and spindle assembly","description":"Based on GO terms dominated by gamma-tubulin complex localization, microtubule nucleation at the MTOC, and mitotic spindle assembly, the cluster seems focused on microtubule organization and spindle formation. Some unrelated terms appear, but the core signals point to spindle/microtubule dynamics.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033566","count":1},{"id":"GO:0051415","count":1},{"id":"GO:0090307","count":1},{"id":"GO:0051417","count":1},{"id":"GO:0018258","count":1}]},{"hash":"986083718582920246","title":"Regulation of signaling and proliferation","description":"This cluster centers on upregulation of key signaling pathways (ERK cascade, PI biosynthesis) and associated cell proliferation, with additional neural, immune, and developmental GO terms suggesting broad regulatory roles in signaling that influence tissue development and immune responses. The terms point to a cohesive theme of signaling control rather than a single specific process, hence a label focused on signaling regulation and proliferation.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":2},{"id":"GO:0010513","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0051586","count":2},{"id":"GO:0043311","count":1}]},{"hash":"1319787263638222253","title":"Cytokine-regulated antiviral immune response","description":"The terms show coordinated regulation of multiple cytokines (IL-2, IL-4, IL-10, IL-1\u03b2) and interferon pathways, with both positive and negative controls, alongside defense against virus and interferon signaling. This points to a small module of immune signaling centered on cytokine-mediated tuning of T cell activity and antiviral responses, rather than a single effector process.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032703","count":2},{"id":"GO:0032689","count":2},{"id":"GO:0042130","count":2},{"id":"GO:0032733","count":2},{"id":"GO:0032753","count":2}]},{"hash":"723808609384060512","title":"Embryonic organogenesis and tissue differentiation","description":"These proteins show GO terms tied to developmental processes across multiple organs (metanephric renal vesicle morphogenesis, nephron tubule epithelial differentiation, atrial cardiac muscle cell differentiation, and female gonad development). This strongly points to embryonic organogenesis and tissue differentiation as a unifying theme, with other terms reflecting general cellular regulation rather than a single pathway. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0072283","count":1},{"id":"GO:0021937","count":1},{"id":"GO:0008585","count":1},{"id":"GO:0050859","count":1},{"id":"GO:0055011","count":1}]},{"hash":"1856522179147607786","title":"Unknown","description":"The GO terms span multiple developmental processes (spinal cord, skin, retina) and diverse stress/ signaling responses (TGF-beta, hypoxia, cadmium, TORC1, actin nucleation, chromatin modifications) with no clear single function tying the proteins together, so a cohesive label is not evident.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":1},{"id":"GO:0071560","count":1},{"id":"GO:0071276","count":1},{"id":"GO:1904263","count":1},{"id":"GO:0034316","count":1}]},{"hash":"717617404377494005","title":"ECM adhesion and PNS myelination","description":"Top GO terms center on extracellular matrix organization (collagen fibrils), integrin- and cell-matrix adhesion and signaling, leukocyte migration, and peripheral nervous system myelination. This suggests a coherent cluster focused on ECM\u2013cell adhesion processes that support PNS myelination and associated cell movement/differentiation. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022011","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0033631","count":2},{"id":"GO:0002523","count":2},{"id":"GO:0007229","count":2}]},{"hash":"497004021832002847","title":"Developmental ECM Remodeling and Adhesion","description":"The top GO terms include nervous system development and regulation of synapse structure, alongside extracellular matrix interactions such as positive/negative regulation of metallopeptidase activity, calcium-independent cell-matrix adhesion, and hyaluronan metabolism. This combination points to tissue morphogenesis and neural development driven by ECM remodeling and cell-ECM adhesion, with one term (stamen formation) likely a cross-species annotation noise. Therefore, a label focusing on developmental ECM remodeling and adhesion best captures the cluster\u2019s common theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:1905050","count":1},{"id":"GO:0060670","count":1},{"id":"GO:0007161","count":1},{"id":"GO:0050803","count":1}]},{"hash":"363220962300780442","title":"Apoptosis and DNA Damage Response Regulation","description":"The top GO terms cluster around regulation of apoptosis (positive regulation of keratinocyte apoptotic process; positive regulation of intrinsic apoptotic signaling in response to DNA damage) and signaling pathways that modulate stress responses (negative regulation of TNF-mediated signaling; regulation of protein sumoylation). While there are also terms linked to development (heart morphogenesis) and growth, the strongest shared theme is control of cell fate under stress and DNA damage, i.e., apoptosis and DNA damage response regulation.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:1902174","count":1},{"id":"GO:1904333","count":1},{"id":"GO:0010804","count":1},{"id":"GO:0033235","count":1}]},{"hash":"585843924543521322","title":"Central Carbon Metabolism and Terpenoid Biosynthesis","description":"The top GO terms cluster around glycolysis, the TCA cycle, and the pentose phosphate pathway (including the reductive PPP), plus terpenoid biosynthesis via the MEP pathway. This suggests a functional group of enzymes involved in core carbon metabolism and isoprenoid precursor production. Some unrelated terms appear in the list, so the signal is not perfect, but the dominant theme is metabolic flux through central carbon pathways and terpenoid biosynthesis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":2},{"id":"GO:0009052","count":1},{"id":"GO:0006096","count":1},{"id":"GO:0006098","count":1},{"id":"GO:0019253","count":1}]},{"hash":"1641635540882513682","title":"Hair Keratinization Cluster","description":"The strongest signals are keratinization and hair cycle, pointing to roles in skin/hair differentiation and keratinocyte biology. The other GO terms appear diverse and may reflect incidental associations or multifunctional proteins, so the core theme is keratinization/hair-related structure rather than a single unified process.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":3},{"id":"GO:0042633","count":2},{"id":"GO:0010963","count":1},{"id":"GO:0002093","count":1},{"id":"GO:0031578","count":1}]},{"hash":"1366184925519233872","title":"DNA replication and repair machinery","description":"The terms with highest counts are DNA repair, DNA replication, mitotic cell cycle, and DNA-templated transcription, pointing to roles in genome maintenance and cell division. Additional terms like centrosome cycle and regulation of JUN kinase activity reinforce a theme of cell cycle control and DNA damage response. Some terms (caveolin-mediated endocytosis, mammary gland epithelial cell proliferation, cytosine metabolism) are less central, likely reflecting secondary functions or annotation noise.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006281","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0072584","count":2}]},{"hash":"2133891849575898252","title":"Unknown","description":"There is no cohesive functional theme across the top GO terms: immune response to lipopolysaccharide, regulation of miRNA transcription, and multiple tissue- development processes are represented in a scattered way, with no clear shared function among the proteins, especially given the tiny cluster size and no interactions. This cluster therefore cannot be given a specific functional label beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902894","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0010980","count":2},{"id":"GO:2000288","count":2},{"id":"GO:0072366","count":2}]},{"hash":"83439229905546214","title":"Plant secondary metabolite metabolism","description":"This cluster features GO terms tied to the biosynthesis and catabolism of plant secondary metabolites, notably strigolactones, stilbenes, and alkaloids, suggesting a common theme around plant specialized metabolism. While some terms touch general metabolism (lipids, vitamins, nucleotides) and a few outliers exist, the presence of plant-specific pathways provides the strongest cohesive signal.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":2},{"id":"GO:0009820","count":2},{"id":"GO:1901601","count":2},{"id":"GO:0097755","count":2},{"id":"GO:0042619","count":2}]},{"hash":"2281282722325222062","title":"Rho-GTPase-driven axonogenesis","description":"The GO terms point strongly to Rho-mediated signal transduction and regulation of GTPase activity, along with both positive and negative regulation of axonogenesis, and cellular responses linked to cytoskeletal dynamics. This pattern suggests a cluster centered on Rho-driven actin remodeling that modulates axon growth. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050771","count":1},{"id":"GO:0071461","count":1},{"id":"GO:2000249","count":1},{"id":"GO:0007266","count":1},{"id":"GO:0071260","count":1}]},{"hash":"1639859596589572552","title":"Embryonic Development and Morphogenesis","description":"The terms center on development and formation of tissues and organs across embryogenesis: heart cushion EMT, cartilage morphogenesis, placenta-related differentiation, left-right patterning, endocrine organ and pancreatic cell development, and germline encapsulation. Though small and diverse, they share a common theme of embryonic tissue morphogenesis and organ development.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0060536","count":1},{"id":"GO:0060806","count":1},{"id":"GO:0060972","count":1}]},{"hash":"1776128136604043510","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning methionine metabolism and one-carbon/methionine-cycle processes, development and differentiation in various tissues, and even xenobiotic catabolic activities. With no clear, single functional theme tying all terms together (and no edges linking proteins), there isn\u2019t a cohesive cluster function to label beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":2},{"id":"GO:0009087","count":1},{"id":"GO:0006730","count":1},{"id":"GO:0006556","count":1},{"id":"GO:0033353","count":1}]},{"hash":"1557995059986507020","title":"Unknown","description":"The top GO terms are highly diverse, spanning kidney development, pigment transport, radial glial differentiation, oligodendrocyte progenitor regulation, equator specification, follicle cell microvillus length, neuron adhesion, corticospinal tract morphogenesis, and synaptic assembly/transmission. This mix lacks a single coherent biological theme or function linking the proteins, and there are no interactions evident (edges/triangles = 0). Therefore no meaningful, specific cluster label can be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001657","count":2},{"id":"GO:1902910","count":1},{"id":"GO:0060019","count":1},{"id":"GO:0070445","count":1},{"id":"GO:0045317","count":1}]},{"hash":"281481414093933273","title":"Multi-tissue developmental processes","description":"The terms cluster around developmental processes across multiple tissues (inner ear, heart, retina, gonad, muscle, digestive tract) and include regulation of Wnt signaling, suggesting a broad developmental program rather than a single, cohesive pathway. Hence, a general label like \u201cMulti-tissue developmental processes\u201d captures the shared theme without overstating specificity.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042491","count":3},{"id":"GO:0061296","count":3},{"id":"GO:0021937","count":3},{"id":"GO:0008585","count":3},{"id":"GO:2000288","count":3}]},{"hash":"20051059283330442","title":"Glycan Biosynthesis and Cell Wall Components","description":"This cluster\u2019s top GO terms center on the biosynthesis and modification of glycan-containing molecules, including dolichol-linked oligosaccharide biosynthesis, lipid glycosylation, peptidoglycan and lipoteichoic acid biosynthesis, and glycosylated plant pigment pathways (kaempferol and anthocyanin glucosides). The common thread appears to be the creation and modification of glycans and glycoconjugates that contribute to cell wall and surface structures in diverse organisms, with some plant-specific glycosylation examples embedded. Confidence in a single cohesive theme is moderate due to the inclusion of plant pigment biosynthesis terms alongside bacterial cell wall biosynthesis terms, but the glycan biosynthesis angle is the strongest shared element.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0008360","count":3},{"id":"GO:0033330","count":3},{"id":"GO:0070395","count":3},{"id":"GO:0070980","count":3},{"id":"GO:0009718","count":3}]},{"hash":"1116992823308632604","title":"Neuronal morphogenesis and vesicle trafficking","description":"The GO terms cluster around neural development and morphology (auditory receptor cell morphogenesis; branching morphogenesis of a nerve; tubulin/filopodium dynamics) and explicit vesicle-associated processes (evoked neurotransmitter secretion; endosome transport), suggesting a module involved in neural growth, cytoskeletal organization, and synaptic vesicle trafficking.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0002093","count":3},{"id":"GO:0031578","count":3},{"id":"GO:0007021","count":3},{"id":"GO:0061670","count":3},{"id":"GO:0051489","count":3}]},{"hash":"1484210350676497206","title":"Embryonic organ morphogenesis","description":"The top GO terms cover multiple organ development and morphogenesis processes (heart, retina, pancreas cell fate, gonad, digestive tract, pituitary) and include Wnt signaling regulation, suggesting the proteins collectively relate to embryonic tissue formation rather than a single specific function. This broad, development-centered theme justifies a label focused on embryonic organ morphogenesis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061296","count":1},{"id":"GO:0021937","count":1},{"id":"GO:0008585","count":1},{"id":"GO:2000288","count":1},{"id":"GO:0030111","count":1}]},{"hash":"211316151659706545","title":"Embryonic morphogenesis and BMP signaling","description":"Proteins here show enrichment for embryonic development and tissue morphogenesis, including ureteric bud development, limb morphogenesis, chondroblast differentiation, bone formation, and BMP signaling regulation, suggesting a shared role in embryonic morphogenesis and BMP-mediated organ/skeletal development.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001658","count":2},{"id":"GO:0032331","count":2},{"id":"GO:0003181","count":2},{"id":"GO:0033690","count":2},{"id":"GO:0060710","count":2}]},{"hash":"1804388586737752320","title":"Leukocyte trafficking and immune regulation","description":"The top GO terms cluster around neutrophil migration and homeostasis, NK and gamma-delta T cell activation, macrophage activation regulation, and anti-inflammatory IL-10 production, suggesting a coherent theme of leukocyte trafficking and modulation of immune responses; a couple of terms like spermatid development and general proteolysis may be peripheral.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072672","count":2},{"id":"GO:0002859","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0043031","count":2},{"id":"GO:2001181","count":2}]},{"hash":"199589863020095879","title":"Endosomal-lysosomal trafficking and ubiquitination","description":"The GO terms point to endosomal-lysosomal transport (endosome to lysosome), ubiquitin-dependent sorting via the multivesicular body (MVB) pathway, and ESCRT-related protein degradation, which together define a shared role in membrane trafficking and protein turnover. A few terms (B cell homeostasis, keratinocyte differentiation, imaginal disc growth) are less connected and reflect more general regulatory functions.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001782","count":2},{"id":"GO:0051092","count":2},{"id":"GO:1903774","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0030216","count":1}]},{"hash":"2098806673988888598","title":"Ubiquitination and Chromatin Regulation","description":"The top GO terms cluster around ubiquitin-related processes (ubiquitin-dependent ERAD, histone ubiquitination, and autoubiquitination) and chromatin-related functions (PML body organization and histone acetylation). This suggests a theme of ubiquitin-driven regulation of chromatin and nuclear processes, with additional hints of nuclear receptor signaling (retinoic acid receptor signaling and vitamin D response). Some terms are obsolete, likely reflecting historical annotations, but the core connection remains ubiquitin-mediated chromatin/nuclear regulation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:1903886","count":2},{"id":"GO:0030578","count":2},{"id":"GO:0070535","count":2},{"id":"GO:2000620","count":2}]},{"hash":"1983604274850425406","title":"TNF-NF-kappaB Signaling and Apoptosis Regulation","description":"Based on the non-obsolete terms, this cluster centers on TNF-mediated signaling and downstream NF-kappaB activation, with overlapping regulation of apoptosis. Terms like TNF-mediated signaling, positive regulation of TNF signaling, and activation of NF-kappaB-inducing kinase point to inflammatory survival signaling, complemented by apoptosis regulation. Some obsolete histone modification and ubiquitination terms appear peripheral, but the core theme remains TNF/NF-\u03baB signaling and apoptosis control.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070512","count":3},{"id":"GO:0042981","count":3},{"id":"GO:0070535","count":3},{"id":"GO:2000620","count":3},{"id":"GO:0033209","count":3}]},{"hash":"842833241487209760","title":"Inflammatory Cytokine Signaling","description":"This cluster is dominated by terms related to immune and inflammatory signaling, including positive regulation of chemokine production, positive regulation of IL-17\u2013mediated signaling, and defense response to virus, suggesting a cohesive theme of cytokine/chemokine\u2013mediated inflammatory responses and antiviral defense. While a few terms point to more general regulatory processes (e.g., apoptosis regulation, sumoylation, amino acid starvation response), the prominent immune signaling terms provide a reasonable basis for this label.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903886","count":1},{"id":"GO:0045869","count":1},{"id":"GO:0018032","count":1},{"id":"GO:0034198","count":1},{"id":"GO:1903883","count":1}]},{"hash":"870668478166169577","title":"Unknown","description":"These three proteins have a dispersed set of GO terms, including cholesterol efflux regulation, fluoride response, lipoxygenase pathway, regulation of kinase activity, apoptosis, and kidney development, with several obsolete terms. There is no clear single pathway or shared function tying them together, so a cohesive label isn\u2019t identifiable from these terms alone.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010875","count":1},{"id":"GO:1902617","count":1},{"id":"GO:0019372","count":1},{"id":"GO:1903634","count":1},{"id":"GO:1903629","count":1}]},{"hash":"78177090995800754","title":"Keratinization and Hair Cycle Proteins","description":"These proteins show strong signals for keratinization and hair cycle processes, indicating a skin/hair biology function centered on keratinocyte differentiation and hair follicle biology. Additional terms related to cytoskeletal assembly (tubulin complex) and morphogenesis of hair-associated structures provide supportive context, suggesting a role in the structural organization of hair/epithelial tissues. Overall, the cluster seems best described by a keratinization/hair cycle theme.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":3},{"id":"GO:0042633","count":2},{"id":"GO:0002093","count":1},{"id":"GO:0031578","count":1},{"id":"GO:0007021","count":1}]},{"hash":"1020380514795805459","title":"Unknown","description":"The top terms span sensory learning, synaptic transport, pigment organization, neural and embryonic development, fungal sporulation, and stem cell maintenance, showing no single cohesive function or pathway linking the proteins. With zero edges and a highly heterogeneous set of GO terms, there isn\u2019t a clear common theme to label the cluster more specifically.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008355","count":1},{"id":"GO:0048490","count":1},{"id":"GO:0008057","count":1},{"id":"GO:0055059","count":1},{"id":"GO:2000222","count":1}]},{"hash":"2066591689836842646","title":"Embryonic development and organ morphogenesis","description":"The top GO terms point to broad developmental and morphogenetic processes, including heart/em Endocardial cushion EMT, placenta-related development, left-right patterning, cartilage morphogenesis, and pancreatic/endocrine system development. A few RNA processing terms appear but with low support, suggesting the core signal is embryonic development and tissue/organ morphogenesis rather than a single specific pathway. Confidence in this theme is moderate as the cluster is small and diverse, but the developmental pattern is the most coherent thread.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0032298","count":1},{"id":"GO:0060536","count":1},{"id":"GO:0000055","count":1}]},{"hash":"1093950972383586668","title":"Unknown","description":"The top GO terms are Diverse, including positive regulation of TOR signaling, intraciliary transport for cilium assembly, mushroom body development, translation, and responses to amino acids. With no single dominant function linking all terms and minimal contextual overlap among the terms, there isn\u2019t a clear, cohesive biological theme for these proteins. ","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032008","count":1},{"id":"GO:0035735","count":1},{"id":"GO:0016319","count":1},{"id":"GO:0000186","count":1},{"id":"GO:0071230","count":1}]},{"hash":"2280366916028467151","title":"PNS Axonogenesis and Schwann Cell Differentiation","description":"The cluster\u2019s top GO terms are dominated by peripheral nervous system\u2013related processes: axonogenesis, axon diameter regulation, axon regeneration, Schwann cell proliferation, and glial differentiation signals. Neurofilament bundle assembly and microtubule cytoskeleton polarity further point to coordinated cytoskeletal remodeling for axon growth. A few terms (e.g., complement activation) appear as noise or unrelated annotations, but the dominant theme is development and growth of PNS axons and Schwann cell differentiation. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0060020","count":3},{"id":"GO:0030951","count":3},{"id":"GO:0090343","count":3},{"id":"GO:0010625","count":3}]},{"hash":"722260937869137533","title":"Developmental signaling and stress responses","description":"Top GO terms suggest tissue development (spinal cord, skin, retina) alongside cellular responses to growth signals (TGF-beta, TORC1) and stress (hypoxia, cadmium). This indicates a cluster enriched for developmental signaling with concurrent environmental response pathways, rather than a single specific function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":1},{"id":"GO:0071560","count":1},{"id":"GO:0071276","count":1},{"id":"GO:1904263","count":1},{"id":"GO:0034316","count":1}]},{"hash":"850361377443811546","title":"Hair Keratinization","description":"The top GO terms are hair cycle and keratinization, each with equal support, suggesting these proteins participate in keratin production and structural changes during hair follicle cycling. The cluster therefore represents hair keratinization processes rather than general cell functions.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042633","count":3},{"id":"GO:0031424","count":3}]},{"hash":"1337742255940048953","title":"Splicing and mRNA stability regulation","description":"The top GO terms cluster around RNA processing: mRNA splicing via the spliceosome, splice site recognition, cis-splicing, and regulation/stabilization of mRNA (including stress-responsive stability). Although estrogen receptor signaling appears, the dominant signal is post-transcriptional control of mRNA processing and stability, suggesting these proteins function in RNA splicing and mRNA regulation rather than broader signaling. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030520","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0010610","count":2},{"id":"GO:0048255","count":2}]},{"hash":"546719035301822254","title":"Neural development and synaptic signaling","description":"The top GO terms cluster around nervous system development and synaptic function: protein localization to synapse, retrograde trans-synaptic signaling by nitric oxide, zonula adherens assembly (cell junctions at synapses), myelination in the peripheral nervous system, regulation of collateral sprouting, and activation of GTPase activity, with supporting roles for Wnt signaling in neural patterning. Together these points suggest a cohesive theme of neuronal development, synapse formation, and associated signaling, rather than a single isolated pathway.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007314","count":1},{"id":"GO:0035418","count":1},{"id":"GO:0030111","count":1},{"id":"GO:0006508","count":1},{"id":"GO:0050953","count":1}]}]