{"hash":"830930772020286811","title":"Protein folding, targeting, and iron-sulfur cluster biogenesis","description":"The cluster\u2019s terms predominantly point to protein biogenesis and quality control: cellular response to unfolded proteins, SRP-dependent cotranslational targeting to membranes, and chaperone-related protein folding, complemented by iron-sulfur cluster assembly. Some stress-related annotations (negative regulation of heat response, regulation of apoptotic signaling under oxidative stress) fit a broader proteostasis/stress response context. A few terms (DNA replication, karyogamy) are less connected and may reflect annotation noise or multifunctional roles, but the dominant theme centers on protein folding/targeting and cofactor biogenesis.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"members":[{"accession":"XP_001329734.1","go_terms":["GO:0000902","GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"XP_001319235.1","go_terms":[]},{"accession":"XP_001309271.1","go_terms":["GO:0030420","GO:0090503","GO:0031126","GO:0017001","GO:0034247","GO:0046677","GO:0006364","GO:0098789","GO:0034414","GO:0019243"]}],"graph":[["XP_001319235.1","XP_001329734.1",0.844]],"all_go_terms":{"GO:0034620":1,"GO:1900035":1,"GO:0006616":1,"GO:0006880":1,"GO:1903751":1,"GO:0006260":1,"GO:0000742":1,"GO:1902037":1,"GO:0070389":1,"GO:0016226":1,"GO:0090084":1,"GO:0031204":1,"GO:1903382":1,"GO:0070880":1,"GO:0000902":1,"GO:0019243":1,"GO:0006364":1,"GO:0017001":1,"GO:0031126":1,"GO:0090503":1,"GO:0030420":1,"GO:0034414":1,"GO:0098789":1,"GO:0046677":1,"GO:0034247":1},"recipe_readded":["XP_001321164.1","XP_001311522.1","XP_001323959.1","XP_001323759.1","XP_001321671.1","XP_001311850.1","XP_001320393.1","XP_001307776.1","XP_001319129.1","XP_001326142.1","XP_001312891.1","XP_001329727.1","XP_001322190.1","XP_001584482.1","XP_001579911.1","XP_001313154.1","XP_051081630.1","XP_001325636.1","XP_001582522.1","XP_001317882.1"]}