{"hash":"578295510400860573","title":"Neuronal stress response and proteostasis","description":"The cluster includes terms tied to handling oxidative stress (negative regulation of ROS biosynthesis, oxidative stress-induced neuron apoptotic signaling), autophagy/quality-control pathways (mitophagy, aggresome assembly, protein monoubiquitination), and signaling and neuronal-specific processes (NF-kappaB signaling, dopamine uptake, neuron survival). Together these point to a cohesive theme of neuronal cellular stress response and proteostasis, balancing survival and death under oxidative damage.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"members":[{"accession":"XP_001309054.1","go_terms":[]},{"accession":"XP_001312826.1","go_terms":[]},{"accession":"XP_051101678.1","go_terms":[]},{"accession":"XP_001319442.1","go_terms":[]},{"accession":"XP_001279654.1","go_terms":[]},{"accession":"XP_001329146.1","go_terms":["GO:0035774","GO:0000423","GO:0032436","GO:0000266","GO:0099074","GO:0090201","GO:0033132","GO:0051865","GO:0043388","GO:0051583","GO:0036205","GO:0051412","GO:0023035","GO:0046329","GO:1903265","GO:0070936","GO:0090258","GO:0006986","GO:0070842","GO:0070979","GO:0048078","GO:0090141","GO:0010918","GO:0085020","GO:0042787","GO:1902283","GO:0071287","GO:1903427","GO:0070534","GO:0043123","GO:0060546","GO:0010636","GO:1903382","GO:2001171","GO:1902530","GO:0055069","GO:1905366","GO:0008344","GO:1903542","GO:0097039","GO:0010637","GO:0090394","GO:1904049","GO:0097237","GO:0042551","GO:0070050","GO:0006513","GO:1903378","GO:0051967","GO:0006351","GO:1903377","GO:0046676"]},{"accession":"XP_001315097.1","go_terms":["GO:0018230","GO:0048733","GO:0042144"]},{"accession":"XP_001304697.1","go_terms":[]},{"accession":"XP_001308695.1","go_terms":[]},{"accession":"XP_001329148.1","go_terms":[]},{"accession":"XP_001291579.2","go_terms":[]},{"accession":"XP_001302778.1","go_terms":[]},{"accession":"XP_001291475.2","go_terms":[]},{"accession":"XP_001308098.1","go_terms":["GO:0019061","GO:0006457","GO:0019064","GO:0019068","GO:0030260","GO:0050900","GO:0010849","GO:0000413","GO:0075713","GO:0019076","GO:0019058","GO:0044829","GO:0048453","GO:2000276","GO:0071492","GO:0034389","GO:0006278","GO:0050714","GO:1901407"]},{"accession":"XP_001325399.1","go_terms":[]},{"accession":"XP_001579402.1","go_terms":[]},{"accession":"XP_001581585.1","go_terms":[]},{"accession":"XP_001302900.1","go_terms":[]},{"accession":"XP_001316260.1","go_terms":[]},{"accession":"XP_001308686.1","go_terms":[]},{"accession":"XP_001320852.1","go_terms":[]},{"accession":"XP_001582246.1","go_terms":["GO:0007300","GO:0042989","GO:0050434","GO:0007436","GO:0043547","GO:1900028","GO:1900029","GO:0030838","GO:0051496","GO:0071689","GO:0030845","GO:0001843","GO:0051054","GO:0044396","GO:0032781","GO:0007488","GO:0030041","GO:0090338","GO:0050821","GO:0071363","GO:0010632","GO:0032220","GO:0035193","GO:0051497","GO:0045944","GO:1903475","GO:1903477","GO:2000300"]},{"accession":"XP_001302313.1","go_terms":[]},{"accession":"XP_001306765.1","go_terms":["GO:0045047","GO:0006465"]},{"accession":"XP_051112815.1","go_terms":[]},{"accession":"XP_001327048.1","go_terms":["GO:0060384","GO:0061580","GO:0003094","GO:0035860","GO:0070395","GO:0014846","GO:0060686","GO:0002063","GO:0042425","GO:0040037","GO:0032836","GO:0007417"]},{"accession":"XP_001580375.1","go_terms":[]}],"graph":[["XP_001580375.1","XP_001327048.1",0.682]],"all_go_terms":{"GO:1903427":1,"GO:0036205":1,"GO:0060546":1,"GO:1905366":1,"GO:0070842":1,"GO:0043123":1,"GO:0000423":1,"GO:0006513":1,"GO:0051583":1,"GO:1903378":1,"GO:0042787":1,"GO:0048078":1,"GO:0070979":1,"GO:0090258":1,"GO:0010918":1,"GO:0090141":1,"GO:0010637":1,"GO:0070050":1,"GO:0051865":1,"GO:0006351":1,"GO:0090201":1,"GO:1903542":1,"GO:0070534":1,"GO:1903377":1,"GO:0085020":1,"GO:0043388":1,"GO:0032436":1,"GO:0033132":1,"GO:0000266":1,"GO:0006986":1,"GO:0010636":1,"GO:0097237":1,"GO:0071287":1,"GO:0051412":1,"GO:0046676":1,"GO:0099074":1,"GO:0097039":1,"GO:0055069":1,"GO:0070936":1,"GO:2001171":1,"GO:0023035":1,"GO:0051967":1,"GO:0042551":1,"GO:1904049":1,"GO:0046329":1,"GO:0090394":1,"GO:1903265":1,"GO:0035774":1,"GO:1902530":1,"GO:1903382":1,"GO:1902283":1,"GO:0008344":1,"GO:0042144":1,"GO:0048733":1,"GO:0018230":1,"GO:0071492":1,"GO:0034389":1,"GO:0030260":1,"GO:0019061":1,"GO:0019064":1,"GO:2000276":1,"GO:0044829":1,"GO:0050900":1,"GO:0019058":1,"GO:0019068":1,"GO:0010849":1,"GO:0019076":1,"GO:0075713":1,"GO:0048453":1,"GO:0050714":1,"GO:0006457":1,"GO:0006278":1,"GO:0000413":1,"GO:1901407":1,"GO:0030041":1,"GO:0090338":1,"GO:0035193":1,"GO:0010632":1,"GO:0050434":1,"GO:0045944":1,"GO:0071363":1,"GO:0050821":1,"GO:0007300":1,"GO:0051496":1,"GO:0032220":1,"GO:1900029":1,"GO:0042989":1,"GO:0030845":1,"GO:2000300":1,"GO:1900028":1,"GO:0001843":1,"GO:1903475":1,"GO:1903477":1,"GO:0007488":1,"GO:0071689":1,"GO:0044396":1,"GO:0043547":1,"GO:0030838":1,"GO:0032781":1,"GO:0051054":1,"GO:0007436":1,"GO:0051497":1,"GO:0045047":1,"GO:0006465":1,"GO:0007417":1,"GO:0014846":1,"GO:0040037":1,"GO:0032836":1,"GO:0060384":1,"GO:0061580":1,"GO:0035860":1,"GO:0042425":1,"GO:0002063":1,"GO:0060686":1,"GO:0003094":1,"GO:0070395":1},"recipe_readded":["XP_001312273.1","XP_001329898.1","XP_001582488.1","XP_001312905.1","XP_001301167.1","XP_001579719.1","XP_001321170.1","XP_001310587.1","XP_051095838.1","XP_001325599.1","XP_001310883.1","XP_001581859.1","XP_001579144.1","XP_001580805.1","XP_001328596.2","XP_001305640.1","XP_001328049.1","XP_001580132.1","XP_001307799.1","XP_001309862.2"]}