{"hash":"417017712488893448","title":"Tryptophan-Kynurenine-NAD Pathway","description":"The top GO terms are dominated by tryptophan/kynurenine metabolism (L-kynurenine catabolic, L-tryptophan catabolic, quinolinate biosynthetic) and related NAD biosynthesis processes, suggesting a core function in converting tryptophan through the kynurenine pathway to NAD. Other metabolic catabolic terms (alanine, glyoxylate) support a broader amino-acid catabolic context, while Notch signaling and glucocorticoid response may reflect regulatory associations rather than defining the cluster\u2019s primary function. Overall, the cluster appears centered on tryptophan metabolism toward NAD biosynthesis with ancillary metabolic connections.","confidence":"Medium","size":14,"edges":90,"triangles":352,"max_degree":13,"top_function":null,"members":[{"accession":"XP_001317416.1","go_terms":["GO:0051604","GO:0006880","GO:0009399","GO:0016226"]},{"accession":"XP_001583076.1","go_terms":["GO:0048082","GO:0042136","GO:0048085","GO:0007615","GO:0035690","GO:0009449","GO:0051454","GO:0010259","GO:0033327","GO:0019722","GO:0071312","GO:0046684","GO:0010761","GO:0006665","GO:0015842","GO:0007623","GO:0033076","GO:0006585","GO:0006587","GO:0042412","GO:0001553","GO:2001120","GO:0071363","GO:0052314","GO:0043052","GO:0001694","GO:0006538"]},{"accession":"XP_001311305.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265"]},{"accession":"XP_001317955.1","go_terms":["GO:0009249","GO:0019464"]},{"accession":"XP_001320829.1","go_terms":["GO:0006545","GO:0006567","GO:0006570","GO:0006569","GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265","GO:0009243","GO:0017000","GO:0009246","GO:0009245","GO:0071555","GO:0046677","GO:0009103"]},{"accession":"XP_001322171.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265"]},{"accession":"XP_001579118.2","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"XP_001583890.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"XP_001299513.1","go_terms":["GO:0009249","GO:0019464"]},{"accession":"XP_001303199.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265"]},{"accession":"XP_001319786.1","go_terms":["GO:0072756","GO:0009228","GO:0072747","GO:0046166","GO:0061732","GO:0006098","GO:0006096","GO:0055114","GO:0052865","GO:0005999","GO:0040008","GO:0010510","GO:0006006","GO:0016114","GO:0009052","GO:0019253","GO:0019596","GO:0032923","GO:0033611","GO:0009234","GO:0019655","GO:0009436","GO:0019529","GO:0000949","GO:0042372","GO:0042867","GO:0022900","GO:0009099","GO:0009097","GO:0019310","GO:0034077","GO:0006086","GO:0009851","GO:0000950","GO:0000951","GO:0061034","GO:0006099"]},{"accession":"XP_001326937.1","go_terms":["GO:0072756","GO:0005999","GO:0072747","GO:0040008","GO:0006098","GO:0046166","GO:0009052","GO:0006096","GO:0019253","GO:0009228","GO:0052865","GO:0061732","GO:0061034","GO:0055114","GO:0006099","GO:0010510","GO:0006006","GO:0016114"]},{"accession":"XP_001330618.1","go_terms":["GO:0006545","GO:0006567","GO:0006570","GO:0006569"]},{"accession":"XP_001306359.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265","GO:0006777","GO:0009688","GO:0006727","GO:0018315","GO:0010118","GO:0045037"]}],"graph":[["XP_001322171.1","XP_001311305.1",0.895],["XP_001322171.1","XP_001317416.1",0.97],["XP_001322171.1","XP_001317955.1",0.92],["XP_001322171.1","XP_001319786.1",0.981],["XP_001322171.1","XP_001320829.1",0.98],["XP_001322171.1","XP_001326937.1",0.983],["XP_001322171.1","XP_001330618.1",0.733],["XP_001322171.1","XP_001579118.2",0.991],["XP_001322171.1","XP_001583076.1",0.942],["XP_001322171.1","XP_001583890.1",0.982],["XP_001322171.1","XP_001299513.1",0.978],["XP_001322171.1","XP_001303199.1",0.985],["XP_001322171.1","XP_001306359.1",0.623],["XP_001317955.1","XP_001311305.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