{"hash":"216730369010951848","title":"Proteostasis and Secretory Pathway Maintenance","description":"This cluster is dominated by terms related to protein quality control and handling of misfolded or unfolded proteins (cellular response to unfolded protein, chaperone-related refolding, negative regulation of heat response) and the secretory pathway (SRP-dependent cotranslational targeting to membrane). Additional terms point to oxidative stress responses (response to hydrogen peroxide) and iron-sulfur cluster assembly, both tied to proper protein maturation and cellular homeostasis. While some terms (DNA replication, karyogamy, hematopoietic stem cell differentiation) are broader, the strongest signal centers on proteostasis and protein targeting, justifying the label as a cohesive proteostasis/secretory pathway maintenance cluster.","confidence":"Medium","size":20,"edges":116,"triangles":344,"max_degree":19,"top_function":"DNA replication","members":[{"accession":"XP_001316329.1","go_terms":["GO:0035774","GO:0031036","GO:0042554","GO:0007616","GO:0007614","GO:0051281","GO:0098735","GO:0010842","GO:0072286","GO:0060048","GO:0086004","GO:0072221","GO:0072205","GO:1901841","GO:1901844","GO:0055003","GO:0019749","GO:0099509","GO:0035502","GO:0006816","GO:0060315","GO:0051764","GO:0042994","GO:0000272","GO:0010459","GO:1900271","GO:0035191","GO:0042694","GO:1901077","GO:2000678","GO:0014044","GO:0001569","GO:0008365","GO:0006470","GO:0048143","GO:0043950","GO:0022011","GO:0042403","GO:0060040","GO:0051562","GO:0090281","GO:0014883","GO:0007602","GO:0055010","GO:0043123","GO:0008284","GO:1905205","GO:0032972","GO:0007601","GO:0006607","GO:0060316","GO:0051591","GO:0051597","GO:0007409","GO:0035562","GO:0007613","GO:0050774","GO:0060291","GO:0070588","GO:0005513","GO:0021762","GO:1903244","GO:0031284","GO:0051384","GO:0032516","GO:1903799","GO:0016237","GO:0035690","GO:2001015","GO:0051028","GO:0008218","GO:0048168","GO:0030437","GO:0000278","GO:0051343","GO:0050665","GO:0000742","GO:0045921","GO:0043065","GO:0046549","GO:0071456","GO:0032465","GO:1901387","GO:0045917","GO:0006469","GO:0099566","GO:0007020","GO:0048741","GO:0008016","GO:0048708","GO:0071277","GO:0008594","GO:1903525","GO:0042144","GO:0007269","GO:0060079","GO:0060487","GO:0048015","GO:0007507","GO:0007114","GO:0048855","GO:0014898","GO:1903087","GO:0051531","GO:0001837","GO:0008360","GO:0032120","GO:0033173","GO:0010515","GO:0051533","GO:0006479","GO:0000086","GO:0038163","GO:0010801","GO:0051412","GO:1902896","GO:2000256","GO:0010800","GO:0007205","GO:0043647","GO:0097274","GO:0010881","GO:0031954","GO:0043388","GO:0071902","GO:0006919","GO:0043547","GO:1903479","GO:0007223","GO:0038095","GO:0045163","GO:0001975","GO:0005980","GO:0007190","GO:2000300","GO:0051000","GO:0070886","GO:0036324","GO:0016061","GO:0002027","GO:0071574","GO:0000754","GO:1901339","GO:0022400","GO:0050906","GO:0002086","GO:0002576","GO:0009738","GO:1900242","GO:0006468","GO:0090151"]},{"accession":"XP_001323976.1","go_terms":["GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"XP_001579096.1","go_terms":["GO:0035774","GO:0031036","GO:0042554","GO:0007616","GO:0007614","GO:0051281","GO:0098735","GO:0010842","GO:0072286","GO:0060048","GO:0086004","GO:0072221","GO:0072205","GO:1901841","GO:1901844","GO:0055003","GO:0019749","GO:0099509","GO:0035502","GO:0006816","GO:0060315","GO:0051764","GO:0042994","GO:0000272","GO:0010459","GO:1900271","GO:0035191","GO:0042694","GO:1901077","GO:2000678","GO:0006470","GO:0036444","GO:0022011","GO:0021762","GO:1902527","GO:0014032","GO:0036324","GO:0014883","GO:0002027","GO:1903244","GO:1905205","GO:0051091","GO:0060316","GO:0035562","GO:0055117","GO:0050774","GO:0000754","GO:0014029","GO:0005513","GO:0045944","GO:0097274","GO:0010880","GO:0033234","GO:0032516","GO:1903799","GO:0070315","GO:0035690","GO:2001015","GO:0001525","GO:0051343","GO:0008218","GO:0001569","GO:0051561","GO:0032465","GO:0014718","GO:0099566","GO:0006919","GO:0048741","GO:0033555","GO:0071277","GO:0014044","GO:0060079","GO:0060487","GO:0007507","GO:0006491","GO:0030948","GO:0051531","GO:0051533","GO:0033173","GO:0014898","GO:0008365","GO:0048143","GO:0043950","GO:0042403","GO:0060040","GO:0051562","GO:0090281","GO:0007602","GO:0055010","GO:0043123","GO:0008284","GO:0032972","GO:0007601","GO:0006607","GO:0051591","GO:0051597","GO:0007409","GO:0007613","GO:0060291","GO:0070588","GO:0031284","GO:0051384","GO:0016237","GO:0051028","GO:0048168","GO:0030437","GO:0000278","GO:0050665","GO:0000742","GO:0045921","GO:0043065","GO:0046549","GO:0071456","GO:1901387","GO:0045917","GO:0006469","GO:0007020","GO:0008016","GO:0048708","GO:0008594","GO:1903525","GO:0042144","GO:0007269","GO:0048015","GO:0007114","GO:0048855","GO:1903087","GO:0001837","GO:0008360","GO:0032120","GO:0010515","GO:0006479","GO:0000086","GO:0038163","GO:0010801","GO:0051412","GO:1902896","GO:2000256","GO:0010800","GO:0007205","GO:0043647","GO:0010881","GO:0031954","GO:0043388","GO:0071902","GO:0043547","GO:1903479","GO:0007223","GO:0038095","GO:0045163","GO:0001975","GO:0005980","GO:0007190","GO:2000300","GO:0051000","GO:0070886","GO:0016061","GO:0071574","GO:1901339","GO:0022400","GO:0050906","GO:0002086","GO:0002576","GO:0009738","GO:1900242","GO:0006468","GO:0090151","GO:1903358","GO:0006907","GO:2001137","GO:0035023","GO:1903861","GO:0048488","GO:0007120","GO:0007121","GO:0090160","GO:0060990","GO:2000601","GO:0030476","GO:0000147","GO:0030100","GO:0007015","GO:0071363","GO:0086036","GO:0050731","GO:0010886","GO:0097320","GO:1901741","GO:0032456","GO:0086029","GO:0043931","GO:1901896","GO:0097050","GO:0007275","GO:0003220","GO:0003151","GO:0003073","GO:0098907","GO:0001824","GO:0071313","GO:0098904","GO:0043129","GO:0097264","GO:2001246","GO:0043588","GO:0007586","GO:0014808","GO:0036368","GO:0060056","GO:1901379","GO:0071872","GO:0007520","GO:0036151","GO:0016540","GO:0098910","GO:0014850"]},{"accession":"XP_001580900.1","go_terms":[]},{"accession":"XP_001583563.1","go_terms":[]},{"accession":"XP_051077590.1","go_terms":[]},{"accession":"XP_051081151.1","go_terms":[]},{"accession":"XP_051082985.1","go_terms":["GO:0039665","GO:0039592","GO:0039685"]},{"accession":"XP_051084909.1","go_terms":[]},{"accession":"XP_051091733.1","go_terms":[]},{"accession":"XP_051093437.1","go_terms":[]},{"accession":"XP_051110911.1","go_terms":[]},{"accession":"XP_001298946.1","go_terms":["GO:0010584","GO:0006487","GO:0046706","GO:0046712","GO:0071405","GO:0046032","GO:0009901","GO:0006256"]},{"accession":"XP_001300506.1","go_terms":["GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"XP_051076864.1","go_terms":["GO:0039665","GO:0039592","GO:0039685"]},{"accession":"XP_051082630.1","go_terms":["GO:0039665","GO:0039592","GO:0039685"]},{"accession":"XP_001310413.1","go_terms":["GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"XP_001301722.1","go_terms":[]},{"accession":"XP_001313071.1","go_terms":["GO:2000624","GO:0030466","GO:0071044","GO:0009048","GO:0006449","GO:0000294","GO:0009863","GO:0032201","GO:0071347","GO:0009867","GO:0030538","GO:0061158","GO:0048571","GO:0008298","GO:0070478","GO:2000815","GO:0010182","GO:0071222","GO:0039520","GO:0019082","GO:0039694","GO:0006351","GO:0006396","GO:0032508","GO:0000184","GO:0090305"]},{"accession":"XP_051107652.1","go_terms":[]}],"graph":[["XP_051082630.1","XP_001313071.1",0.724],["XP_051082630.1","XP_001323976.1",0.641],["XP_051082630.1","XP_001579096.1",0.631],["XP_051082630.1","XP_051091733.1",0.826],["XP_051082630.1","XP_051093437.1",0.961],["XP_051082630.1","XP_051084909.1",0.943],["XP_051082630.1","XP_001298946.1",0.985],["XP_051082630.1","XP_001300506.1",0.64],["XP_001579096.1","XP_001310413.1",0.585],["XP_001579096.1","XP_001313071.1",0.971],["XP_001579096.1","XP_001323976.1",0.816],["XP_001579096.1","XP_051076864.1",0.677],["XP_001579096.1","XP_051077590.1",0.722],["XP_001579096.1","XP_051081151.1",0.737],["XP_001579096.1","XP_051082985.1",0.771],["XP_001579096.1","XP_051084909.1",0.813],["XP_001579096.1","XP_051091733.1",0.589],["XP_001579096.1","XP_051093437.1",0.901],["XP_001579096.1","XP_051107652.1",0.945],["XP_001579096.1","XP_051110911.1",0.789],["XP_001579096.1","XP_001298946.1",0.975],["XP_001579096.1","XP_001300506.1",0.966],["XP_001579096.1","XP_001301722.1",0.729],["XP_051110911.1","XP_001310413.1",0.555],["XP_051110911.1","XP_001313071.1",0.754],["XP_051110911.1","XP_001323976.1",0.972],["XP_051110911.1","XP_051081151.1",0.827],["XP_051110911.1","XP_051082985.1",0.9],["XP_051110911.1","XP_051084909.1",0.943],["XP_051110911.1","XP_051091733.1",0.93],["XP_051110911.1","XP_051093437.1",0.946],["XP_051110911.1","XP_001298946.1",0.982],["XP_001300506.1","XP_001298946.1",0.982],["XP_001300506.1","XP_001301722.1",0.676],["XP_001300506.1","XP_001310413.1",0.84],["XP_001300506.1","XP_001313071.1",0.884],["XP_001300506.1","XP_001316329.1",0.934],["XP_001300506.1","XP_001323976.1",0.909],["XP_001300506.1","XP_001580900.1",0.93],["XP_001300506.1","XP_001583563.1",0.61],["XP_001300506.1","XP_051076864.1",0.751],["XP_001300506.1","XP_051077590.1",0.902],["XP_001300506.1","XP_051081151.1",0.878],["XP_001300506.1","XP_051082985.1",0.796],["XP_001300506.1","XP_051084909.1",0.936],["XP_001300506.1","XP_051091733.1",0.874],["XP_001300506.1","XP_051093437.1",0.978],["XP_001300506.1","XP_051107652.1",0.929],["XP_051093437.1","XP_001310413.1",0.987],["XP_051093437.1","XP_001313071.1",0.949],["XP_051093437.1","XP_001316329.1",0.944],["XP_051093437.1","XP_001323976.1",0.963],["XP_051093437.1","XP_001580900.1",0.966],["XP_051093437.1","XP_001583563.1",0.682],["XP_051093437.1","XP_051076864.1",0.962],["XP_051093437.1","XP_051077590.1",0.938],["XP_051093437.1","XP_051081151.1",0.948],["XP_051093437.1","XP_051082985.1",0.96],["XP_051093437.1","XP_051084909.1",0.846],["XP_051093437.1","XP_051091733.1",0.697],["XP_051093437.1","XP_051107652.1",0.951],["XP_051093437.1","XP_001298946.1",0.949],["XP_051093437.1","XP_001301722.1",0.962],["XP_001310413.1","XP_001323976.1",0.661],["XP_001310413.1","XP_051091733.1",0.93],["XP_001310413.1","XP_051082985.1",0.693],["XP_001310413.1","XP_051084909.1",0.935],["XP_001310413.1","XP_001298946.1",0.904],["XP_001580900.1","XP_001313071.1",0.872],["XP_001580900.1","XP_001323976.1",0.862],["XP_001580900.1","XP_051081151.1",0.827],["XP_001580900.1","XP_051082985.1",0.643],["XP_001580900.1","XP_051084909.1",0.921],["XP_001580900.1","XP_051091733.1",0.828],["XP_001580900.1","XP_001298946.1",0.965],["XP_001313071.1","XP_001316329.1",0.929],["XP_001313071.1","XP_001323976.1",0.921],["XP_001313071.1","XP_051091733.1",0.797],["XP_001313071.1","XP_051082985.1",0.58],["XP_001313071.1","XP_051084909.1",0.922],["XP_001313071.1","XP_051081151.1",0.95],["XP_001313071.1","XP_051077590.1",0.858],["XP_001313071.1","XP_001298946.1",0.99],["XP_051081151.1","XP_001323976.1",0.865],["XP_051081151.1","XP_051091733.1",0.687],["XP_051081151.1","XP_051084909.1",0.59],["XP_051081151.1","XP_001298946.1",0.973],["XP_051091733.1","XP_001323976.1",0.955],["XP_051091733.1","XP_001583563.1",0.683],["XP_051091733.1","XP_051076864.1",0.941],["XP_051091733.1","XP_051077590.1",0.568],["XP_051091733.1","XP_051082985.1",0.958],["XP_051091733.1","XP_051084909.1",0.957],["XP_051091733.1","XP_001298946.1",0.924],["XP_051091733.1","XP_001301722.1",0.878],["XP_001323976.1","XP_001316329.1",0.846],["XP_001323976.1","XP_001583563.1",0.862],["XP_001323976.1","XP_051076864.1",0.928],["XP_001323976.1","XP_051077590.1",0.858],["XP_001323976.1","XP_051082985.1",0.979],["XP_001323976.1","XP_051084909.1",0.985],["XP_001323976.1","XP_001298946.1",0.992],["XP_001323976.1","XP_001301722.1",0.949],["XP_001298946.1","XP_001301722.1",0.985],["XP_001298946.1","XP_001316329.1",0.979],["XP_001298946.1","XP_051107652.1",0.969],["XP_001298946.1","XP_051082985.1",0.985],["XP_001298946.1","XP_051084909.1",0.961],["XP_001298946.1","XP_051076864.1",0.985],["XP_001298946.1","XP_051077590.1",0.974],["XP_001298946.1","XP_001583563.1",0.872],["XP_051082985.1","XP_051084909.1",0.959],["XP_051076864.1","XP_051084909.1",0.96],["XP_051084909.1","XP_001316329.1",0.749],["XP_051084909.1","XP_001583563.1",0.929],["XP_051084909.1","XP_001301722.1",0.916]],"all_go_terms":{"GO:0051591":2,"GO:0007601":2,"GO:0048855":2,"GO:0035502":2,"GO:0006816":2,"GO:0043123":2,"GO:0010459":2,"GO:0006479":2,"GO:1901387":2,"GO:0007020":2,"GO:0022400":2,"GO:0042994":2,"GO:1900242":2,"GO:0042144":2,"GO:0007269":2,"GO:0072286":2,"GO:0007190":2,"GO:0043950":2,"GO:0051562":2,"GO:0000272":2,"GO:0043547":2,"GO:0022011":2,"GO:0038095":2,"GO:0042403":2,"GO:0045917":2,"GO:0051764":2,"GO:0045921":2,"GO:0048015":2,"GO:0005980":2,"GO:0051000":2,"GO:0014044":2,"GO:0060048":2,"GO:0072205":2,"GO:0032972":2,"GO:1903479":2,"GO:0001975":2,"GO:0016061":2,"GO:0031284":2,"GO:0006469":2,"GO:2001015":2,"GO:0000742":5,"GO:0035191":2,"GO:0090281":2,"GO:0032465":2,"GO:0010800":2,"GO:0050906":2,"GO:0033173":2,"GO:0043388":2,"GO:0042554":2,"GO:0010881":2,"GO:0007223":2,"GO:0051028":2,"GO:0000278":2,"GO:0071902":2,"GO:0031954":2,"GO:0016237":2,"GO:0060316":2,"GO:0008016":2,"GO:2000256":2,"GO:0007114":2,"GO:0048143":2,"GO:0032516":2,"GO:0048741":2,"GO:0086004":2,"GO:0007409":2,"GO:0099566":2,"GO:0008360":2,"GO:0007602":2,"GO:0060040":2,"GO:0035562":2,"GO:0072221":2,"GO:0007616":2,"GO:0010801":2,"GO:0031036":2,"GO:0045163":2,"GO:0002027":2,"GO:0055010":2,"GO:0055003":2,"GO:0030437":2,"GO:0035690":2,"GO:1903525":2,"GO:0071574":2,"GO:0051281":2,"GO:0097274":2,"GO:0009738":2,"GO:1903799":2,"GO:0006919":2,"GO:0070588":2,"GO:0070886":2,"GO:0007205":2,"GO:0060315":2,"GO:0010515":2,"GO:0051412":2,"GO:0043065":2,"GO:2000678":2,"GO:0071456":2,"GO:0001837":2,"GO:0099509":2,"GO:1900271":2,"GO:0050665":2,"GO:1901844":2,"GO:0051343":2,"GO:0035774":2,"GO:0007613":2,"GO:0000086":2,"GO:0043647":2,"GO:1901339":2,"GO:1903244":2,"GO:0002576":2,"GO:0051597":2,"GO:0014898":2,"GO:0051384":2,"GO:0006470":2,"GO:0021762":2,"GO:0060487":2,"GO:0036324":2,"GO:0038163":2,"GO:0008218":2,"GO:0048708":2,"GO:1901841":2,"GO:0060291":2,"GO:0019749":2,"GO:1905205":2,"GO:0002086":2,"GO:1901077":2,"GO:2000300":2,"GO:0014883":2,"GO:0008365":2,"GO:0060079":2,"GO:1902896":2,"GO:0050774":2,"GO:0000754":2,"GO:0071277":2,"GO:0006468":2,"GO:0051533":2,"GO:0042694":2,"GO:0090151":2,"GO:0007614":2,"GO:0006607":2,"GO:0032120":2,"GO:0008284":2,"GO:0046549":2,"GO:1903087":2,"GO:0051531":2,"GO:0008594":2,"GO:0001569":2,"GO:0005513":2,"GO:0010842":2,"GO:0098735":2,"GO:0007507":2,"GO:0048168":2,"GO:0034620":3,"GO:1900035":3,"GO:0006616":3,"GO:0006880":3,"GO:1903751":3,"GO:0006260":3,"GO:1902037":3,"GO:0070389":3,"GO:0016226":3,"GO:0090084":3,"GO:0031204":3,"GO:1903382":3,"GO:0070880":3,"GO:0043129":1,"GO:1903861":1,"GO:0033234":1,"GO:0010880":1,"GO:0036368":1,"GO:0036444":1,"GO:0097320":1,"GO:0016540":1,"GO:0051091":1,"GO:0071313":1,"GO:0007586":1,"GO:0098904":1,"GO:0007120":1,"GO:0098907":1,"GO:0007520":1,"GO:0050731":1,"GO:0014718":1,"GO:0033555":1,"GO:0003073":1,"GO:0098910":1,"GO:0048488":1,"GO:0086029":1,"GO:0032456":1,"GO:0086036":1,"GO:2001137":1,"GO:0051561":1,"GO:0014808":1,"GO:0000147":1,"GO:0060990":1,"GO:0003220":1,"GO:0007015":1,"GO:0097050":1,"GO:0043588":1,"GO:0006491":1,"GO:0090160":1,"GO:1901379":1,"GO:0006907":1,"GO:0014850":1,"GO:0055117":1,"GO:0001525":1,"GO:1903358":1,"GO:0045944":1,"GO:0001824":1,"GO:0035023":1,"GO:0030100":1,"GO:1901896":1,"GO:0071872":1,"GO:0014032":1,"GO:0014029":1,"GO:2001246":1,"GO:2000601":1,"GO:0071363":1,"GO:1902527":1,"GO:0060056":1,"GO:0070315":1,"GO:1901741":1,"GO:0030476":1,"GO:0007275":1,"GO:0010886":1,"GO:0003151":1,"GO:0030948":1,"GO:0043931":1,"GO:0097264":1,"GO:0036151":1,"GO:0007121":1,"GO:0039592":3,"GO:0039685":3,"GO:0039665":3,"GO:0006487":1,"GO:0071405":1,"GO:0046032":1,"GO:0009901":1,"GO:0006256":1,"GO:0046712":1,"GO:0010584":1,"GO:0046706":1,"GO:0006449":1,"GO:0090305":1,"GO:0009867":1,"GO:0010182":1,"GO:0048571":1,"GO:0008298":1,"GO:0030538":1,"GO:0019082":1,"GO:0000294":1,"GO:0006351":1,"GO:0039520":1,"GO:0006396":1,"GO:0000184":1,"GO:0032201":1,"GO:2000624":1,"GO:0039694":1,"GO:0070478":1,"GO:0032508":1,"GO:0030466":1,"GO:0009863":1,"GO:0071347":1,"GO:0071222":1,"GO:2000815":1,"GO:0071044":1,"GO:0061158":1,"GO:0009048":1},"recipe_readded":[]}