{"hash":"124864380176809387","title":"Sumoylation-Linked DNA Damage Response","description":"The top GO terms cluster around post-translational modification by sumoylation (autosumoylation and positive regulation of protein sumoylation) and several DNA damage response processes (DNA double-strand break attachment to the nuclear envelope, error-prone translesion synthesis regulation, and mitotic DNA damage checkpoint regulation), suggesting a theme where sumoylation modulates DNA repair/tolerance pathways. Some terms (keratinocyte apoptotic process, vitellogenesis, membrane potential, androgen receptor signaling) are less clearly connected and may reflect broader or off-target functions in this small cluster. Overall, the most coherent thread is sumoylation-influenced DNA damage response, with some outliers.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"XP_001286199.2","go_terms":[]},{"accession":"XP_001324347.1","go_terms":["GO:1904333","GO:1902174","GO:1902231","GO:0010804","GO:0003007","GO:0007296","GO:0060766","GO:0016049","GO:1904290","GO:1990683","GO:0043060","GO:0045838","GO:1990466","GO:0033235","GO:0033234"]},{"accession":"XP_001317008.1","go_terms":[]},{"accession":"XP_001310014.1","go_terms":["GO:0071357","GO:0030850","GO:0046661","GO:0006463","GO:0000492"]}],"graph":[],"all_go_terms":{"GO:1902174":1,"GO:1990466":1,"GO:0033235":1,"GO:0007296":1,"GO:0016049":1,"GO:1904333":1,"GO:1904290":1,"GO:1990683":1,"GO:0045838":1,"GO:0060766":1,"GO:1902231":1,"GO:0043060":1,"GO:0033234":1,"GO:0010804":1,"GO:0003007":1,"GO:0000492":1,"GO:0071357":1,"GO:0046661":1,"GO:0030850":1,"GO:0006463":1},"recipe_readded":["XP_001312571.1","XP_001313136.1","XP_001328898.1","XP_001316746.1","XP_001583928.1","XP_001276954.1","XP_001323882.1","XP_001311351.1","XP_001299927.1","XP_001301380.1","XP_001315100.1","XP_001317762.1","XP_001314666.1","XP_001300212.2","XP_001580296.1","XP_001326896.1","XP_001582331.1","XP_001312605.1","XP_001302364.1","XP_001312837.1"]}