{"hash":"1205128888491690766","title":"Vesicle trafficking and autophagy","description":"This cluster is enriched for autophagy-related processes and membrane trafficking steps (autophagosome maturation, intralumenal vesicle formation, late endosomal microautophagy, ER-to-Golgi transport, peroxisomal matrix import). It also includes components of dense-core vesicle transport in neurons and cilium movement, pointing to a broader theme of intracellular vesicle trafficking and protein quality control. A couple of terms (mRNA export, UV-damage repair) are less central and may be incidental. Overall, the dominant function appears to be vesicle trafficking coupled with autophagy/quality-control processes.","confidence":"Medium","size":21,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"members":[{"accession":"XP_001312068.1","go_terms":["GO:0061738","GO:0031117","GO:0051260","GO:0030420","GO:2001171","GO:0034214","GO:1903862","GO:0032968","GO:0070842","GO:0001824","GO:0006260","GO:0034551","GO:0070682","GO:0033314","GO:0032979","GO:0051013","GO:0046034","GO:1901800","GO:1990171","GO:0016485","GO:0045899","GO:0030968","GO:0006272","GO:0070987","GO:0043335","GO:0070676","GO:0070370","GO:1903007","GO:0090261","GO:0070914","GO:0061641","GO:0061166","GO:1903715","GO:0051301","GO:0006888","GO:0045053","GO:0001319","GO:0035494","GO:0019079","GO:0070414","GO:0097352","GO:0071218","GO:0016562","GO:2000158","GO:0070389","GO:0018279","GO:0006406","GO:0051131","GO:0048219","GO:0030433","GO:1903724","GO:0034599","GO:0090296","GO:0072389","GO:0045041","GO:0016558","GO:0000733","GO:0070407","GO:0070651","GO:0071712","GO:0035617","GO:0019941","GO:0010498","GO:0031412","GO:0003341","GO:1990048","GO:0000027"]},{"accession":"XP_001580713.1","go_terms":["GO:0061738","GO:0031117","GO:0051260","GO:0030420","GO:2001171","GO:0034214","GO:1903862","GO:0032968","GO:0070842","GO:0001824","GO:0006260","GO:0034551","GO:0070682","GO:0033314","GO:0032979","GO:0051013","GO:0046034","GO:1901800","GO:1990171","GO:0016485","GO:0045899","GO:0030968","GO:0006272","GO:0070987","GO:0043335","GO:0070676","GO:0070370","GO:1903007","GO:0090261","GO:0070914","GO:0061641","GO:0061166","GO:1903715","GO:0051301","GO:0006888","GO:0045053","GO:0001319","GO:0035494","GO:0019079","GO:0070414","GO:0097352","GO:0071218","GO:0016562","GO:2000158","GO:0070389","GO:0018279","GO:0006406","GO:0051131","GO:0048219","GO:0030433","GO:1903724","GO:0034599","GO:0090296","GO:0072389","GO:0045041","GO:0016558","GO:0000733","GO:0070407","GO:0070651","GO:0071712","GO:0035617","GO:0019941","GO:0010498","GO:0031412","GO:0003341","GO:1990048","GO:0000027"]},{"accession":"XP_001317603.1","go_terms":[]},{"accession":"XP_001318212.1","go_terms":[]},{"accession":"XP_001326274.1","go_terms":[]},{"accession":"XP_001327648.1","go_terms":[]},{"accession":"XP_001303126.1","go_terms":[]},{"accession":"XP_001305112.1","go_terms":[]},{"accession":"XP_001309547.1","go_terms":[]},{"accession":"XP_001310280.1","go_terms":[]},{"accession":"XP_001321262.1","go_terms":[]},{"accession":"XP_001321290.1","go_terms":[]},{"accession":"XP_001330163.1","go_terms":["GO:1990172","GO:0008333","GO:0061003"]},{"accession":"XP_001583232.1","go_terms":[]},{"accession":"XP_001583359.1","go_terms":[]},{"accession":"XP_001584240.1","go_terms":[]},{"accession":"XP_001300079.1","go_terms":[]},{"accession":"XP_001303901.1","go_terms":[]},{"accession":"XP_001305674.1","go_terms":[]},{"accession":"XP_001303476.1","go_terms":[]},{"accession":"XP_001308217.1","go_terms":[]}],"graph":[["XP_001312068.1","XP_001308217.1",0.541],["XP_001312068.1","XP_001310280.1",0.764],["XP_001312068.1","XP_001321290.1",0.762],["XP_001580713.1","XP_001310280.1",0.585],["XP_001580713.1","XP_001321290.1",0.703]],"all_go_terms":{"GO:0097352":2,"GO:0006406":2,"GO:0016558":2,"GO:0003341":2,"GO:0070914":2,"GO:1990048":2,"GO:0070842":2,"GO:0070676":2,"GO:0061738":2,"GO:0006888":2,"GO:2000158":2,"GO:0070414":2,"GO:0090296":2,"GO:0032968":2,"GO:0019079":2,"GO:0001824":2,"GO:0070651":2,"GO:0051301":2,"GO:0071218":2,"GO:0033314":2,"GO:0048219":2,"GO:0000733":2,"GO:0032979":2,"GO:0071712":2,"GO:0046034":2,"GO:0043335":2,"GO:1903007":2,"GO:0001319":2,"GO:0006272":2,"GO:0061641":2,"GO:0070987":2,"GO:0070682":2,"GO:1903715":2,"GO:0051013":2,"GO:0070370":2,"GO:0034214":2,"GO:0051131":2,"GO:0031117":2,"GO:0090261":2,"GO:0018279":2,"GO:1903724":2,"GO:1990171":2,"GO:0070389":2,"GO:0045899":2,"GO:0010498":2,"GO:1903862":2,"GO:0061166":2,"GO:0035494":2,"GO:2001171":2,"GO:0034599":2,"GO:0045041":2,"GO:0070407":2,"GO:0006260":2,"GO:0045053":2,"GO:0035617":2,"GO:0072389":2,"GO:1901800":2,"GO:0000027":2,"GO:0051260":2,"GO:0030420":2,"GO:0016562":2,"GO:0030433":2,"GO:0031412":2,"GO:0019941":2,"GO:0030968":2,"GO:0016485":2,"GO:0034551":2,"GO:1990172":1,"GO:0061003":1,"GO:0008333":1},"recipe_readded":["XP_001306177.1","XP_001311868.1","XP_001309905.1","XP_001315312.1","XP_001323632.1","XP_001297915.1","XP_051077354.1","XP_001316717.1","XP_001328461.1","XP_001306032.1","XP_001319644.2","XP_001304019.1","XP_001304031.1","XP_001323582.1","XP_001323695.1","XP_001313767.1","XP_001316564.1","XP_001580263.1","XP_001329724.1","XP_001328991.1"]}