{"hash":"969283625258364071","title":"Amino acid catabolism","description":"This cluster shows a prominent presence of catabolic processes for amino acids, notably L-alanine and L-kynurenine (derived from tryptophan), as well as glyoxylate catabolism, suggesting a metabolic focus on amino acid breakdown. The inclusion of pyridoxine (vitamin B6) biosynthesis supports cofactor-related aspects of amino acid metabolism. A Notch signaling pathway term and DNA-templated transcription are present but appear less central to the main theme, indicating they may be background or cross-annotation. Overall, the dominant signal points to amino acid catabolic pathways as the defining function of this cluster.","confidence":"High","size":15,"edges":93,"triangles":319,"max_degree":14,"top_function":"DNA-templated transcription","members":[{"accession":"XP_065997445.1","go_terms":["GO:0031564","GO:0010587","GO:1902219","GO:0031054","GO:0070934","GO:0060567","GO:1901724","GO:0006351"]},{"accession":"XP_066005796.1","go_terms":["GO:0035606","GO:0051402","GO:0008615","GO:0055114","GO:0006096","GO:0009089","GO:0042823","GO:0006006"]},{"accession":"XP_025178501.1","go_terms":["GO:2001234","GO:0071269","GO:1904831","GO:0051092","GO:0019450","GO:0070814","GO:0019346","GO:0019343","GO:0018272","GO:0044524","GO:0019279","GO:0043123","GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"XP_025180439.1","go_terms":["GO:0071357","GO:0030850","GO:0046661","GO:0006463","GO:0000492","GO:0045842","GO:0034454","GO:0021756","GO:0046548","GO:0060613","GO:1903546","GO:0038108","GO:0090526","GO:0003085","GO:0060296","GO:0061087","GO:0035845","GO:1903646","GO:1905515","GO:0070389","GO:1902855","GO:0006478","GO:0050689","GO:0051301","GO:0006986","GO:0070979","GO:0051348","GO:0016570","GO:2001162","GO:0000278","GO:0035457","GO:0045087","GO:1903071","GO:0031145","GO:0036494","GO:0051607","GO:0071360","GO:1902391","GO:0007091","GO:2000324","GO:0015979","GO:0000413","GO:0009736","GO:0035955","GO:0016576","GO:1902325","GO:1903070","GO:0010288","GO:0070301","GO:0051291","GO:2000531","GO:0071276","GO:0043278","GO:1901215","GO:0031400","GO:0009938"]},{"accession":"XP_025181441.2","go_terms":["GO:0006777","GO:0009688","GO:0006727","GO:0018315","GO:0010118","GO:0045037","GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265"]},{"accession":"XP_025181572.1","go_terms":["GO:0051384","GO:0018283","GO:0034354","GO:0009436","GO:0043420","GO:0019442","GO:0007219","GO:0019448","GO:0006546","GO:0042866","GO:0006564","GO:0044571","GO:0019700","GO:0046724","GO:0070903","GO:0008615","GO:0019805","GO:0042853","GO:0097053","GO:0034516","GO:0051591","GO:0019265"]},{"accession":"XP_025182311.1","go_terms":["GO:0019878","GO:0006879","GO:0019679","GO:0006099","GO:0050892","GO:0009791","GO:1990641","GO:0009098","GO:0009097","GO:0010040","GO:0032543","GO:0019298"]},{"accession":"XP_025185256.1","go_terms":["GO:0071357","GO:0030850","GO:0046661","GO:0006463","GO:0050689","GO:0071360","GO:0045087","GO:0008277","GO:0051301","GO:0045454","GO:0000492","GO:0008653","GO:0007346","GO:0071908","GO:0071492","GO:0045070","GO:0071909","GO:0003283","GO:0051661","GO:0072189","GO:0046890","GO:0048496","GO:0050714","GO:0051348","GO:0006986","GO:0000278","GO:0045842","GO:0034454","GO:0021756","GO:0046548","GO:0060613","GO:1903546","GO:0038108","GO:0090526","GO:0003085","GO:0060296","GO:0061087","GO:0035845","GO:1903646","GO:1905515","GO:0070389","GO:1902855","GO:0070979","GO:0042787","GO:0007091","GO:0030433","GO:0006478","GO:0016570","GO:2001162","GO:0035457","GO:1903071","GO:0031145","GO:0036494","GO:0051607","GO:1902391","GO:2000324","GO:0015979","GO:0000413","GO:0009736","GO:0035955","GO:0016576","GO:1902325","GO:1903070","GO:0010288","GO:0070301","GO:0051291","GO:2000531","GO:0071276","GO:0043278","GO:1901215","GO:0031400","GO:0009938"]},{"accession":"XP_025188229.1","go_terms":["GO:0006635","GO:0032385","GO:0019619","GO:0001889","GO:0042594","GO:0060612","GO:0046952","GO:0014070","GO:0046951","GO:0072229","GO:0051260","GO:1901029","GO:0046356","GO:0030435","GO:0010111","GO:1901373","GO:0008203","GO:0007420","GO:0009725","GO:0006550","GO:0042619","GO:1902860","GO:1902109"]},{"accession":"XP_025190183.1","go_terms":["GO:0019596","GO:0019310","GO:0019655","GO:0090180","GO:0034077","GO:0009436","GO:0033611","GO:0000949","GO:0019529","GO:0042867","GO:0009851","GO:0000950","GO:0000951","GO:0009099","GO:0009097","GO:0032923","GO:0009234","GO:0042372","GO:0022900","GO:0006086"]},{"accession":"XP_065993956.1","go_terms":["GO:0048082","GO:0042136","GO:0048085","GO:0007615","GO:0035690","GO:0009449","GO:0051454","GO:0010259","GO:0033327","GO:0019722","GO:0071312","GO:0046684","GO:0010761","GO:0006665","GO:0015842","GO:0007623","GO:0033076","GO:0006585","GO:0006587","GO:0042412","GO:0001553","GO:2001120","GO:0071363","GO:0052314","GO:0043052","GO:0001694","GO:0006538"]},{"accession":"XP_065995009.1","go_terms":[]},{"accession":"XP_025169602.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"XP_025171108.1","go_terms":["GO:0008585","GO:0006099","GO:0006097","GO:0019878","GO:1903976","GO:0006749","GO:0071071","GO:0006740","GO:0009098","GO:1904465","GO:0060253","GO:0006979","GO:0006537","GO:0006741","GO:0006103","GO:0006102","GO:0060696","GO:0048545"]},{"accession":"XP_025174233.1","go_terms":["GO:0019596","GO:0019310","GO:0019655","GO:0090180","GO:0034077","GO:0009436","GO:0033611","GO:0000949","GO:0019529","GO:0042867","GO:0009851","GO:0000950","GO:0000951","GO:0009099","GO:0009097","GO:0032923","GO:0009234","GO:0042372","GO:0022900","GO:0006086"]}],"graph":[["XP_025190183.1","XP_025178501.1",0.906],["XP_025190183.1","XP_025180439.1",0.982],["XP_025190183.1","XP_025181441.2",0.955],["XP_025190183.1","XP_025181572.1",0.979],["XP_025190183.1","XP_025182311.1",0.949],["XP_025190183.1","XP_025185256.1",0.807],["XP_025190183.1","XP_025188229.1",0.956],["XP_025190183.1","XP_065997445.1",0.962],["XP_025190183.1","XP_065995009.1",0.992],["XP_025190183.1","XP_066005796.1",0.92],["XP_025190183.1","XP_025169602.1",0.902],["XP_025190183.1","XP_025174233.1",0.927],["XP_025180439.1","XP_025178501.1",0.987],["XP_025180439.1","XP_025181441.2",0.963],["XP_025180439.1","XP_025181572.1",0.981],["XP_025180439.1","XP_025182311.1",0.977],["XP_025180439.1","XP_025188229.1",0.973],["XP_025180439.1","XP_065993956.1",0.836],["XP_025180439.1","XP_065995009.1",0.99],["XP_025180439.1","XP_066005796.1",0.971],["XP_025180439.1","XP_025169602.1",0.98],["XP_025180439.1","XP_025171108.1",0.675],["XP_025180439.1","XP_025174233.1",0.977],["XP_025188229.1","XP_025178501.1",0.957],["XP_025188229.1","XP_025181441.2",0.92],["XP_025188229.1","XP_025181572.1",0.963],["XP_025188229.1","XP_025182311.1",0.918],["XP_025188229.1","XP_025185256.1",0.929],["XP_025188229.1","XP_065993956.1",0.877],["XP_025188229.1","XP_065995009.1",0.988],["XP_025188229.1","XP_065997445.1",0.99],["XP_025188229.1","XP_066005796.1",0.986],["XP_025188229.1","XP_025169602.1",0.984],["XP_025188229.1","XP_025171108.1",0.864],["XP_025188229.1","XP_025174233.1",0.969],["XP_065995009.1","XP_025178501.1",0.909],["XP_065995009.1","XP_025181441.2",0.888],["XP_065995009.1","XP_025181572.1",0.984],["XP_065995009.1","XP_025185256.1",0.982],["XP_065995009.1","XP_065993956.1",0.758],["XP_065995009.1","XP_065997445.1",0.963],["XP_065995009.1","XP_066005796.1",0.925],["XP_065995009.1","XP_025169602.1",0.962],["XP_065995009.1","XP_025174233.1",0.953],["XP_025185256.1","XP_025178501.1",0.928],["XP_025185256.1","XP_025181441.2",0.759],["XP_025185256.1","XP_025181572.1",0.902],["XP_025185256.1","XP_025182311.1",0.948],["XP_025185256.1","XP_066005796.1",0.985],["XP_025185256.1","XP_025169602.1",0.991],["XP_025185256.1","XP_025171108.1",0.541],["XP_025185256.1","XP_025174233.1",0.894],["XP_025171108.1","XP_025169602.1",0.866],["XP_025171108.1","XP_025174233.1",0.556],["XP_025171108.1","XP_025181572.1",0.6],["XP_025171108.1","XP_025182311.1",0.734],["XP_025171108.1","XP_065993956.1",0.719],["XP_025171108.1","XP_066005796.1",0.948],["XP_065997445.1","XP_025178501.1",0.938],["XP_065997445.1","XP_025181441.2",0.983],["XP_065997445.1","XP_025181572.1",0.986],["XP_065997445.1","XP_025182311.1",0.984],["XP_065997445.1","XP_065993956.1",0.987],["XP_065997445.1","XP_066005796.1",0.549],["XP_065997445.1","XP_025169602.1",0.938],["XP_065997445.1","XP_025174233.1",0.99],["XP_025181441.2","XP_025178501.1",0.692],["XP_025181441.2","XP_025181572.1",0.838],["XP_025181441.2","XP_025182311.1",0.881],["XP_025181441.2","XP_065993956.1",0.803],["XP_025181441.2","XP_066005796.1",0.944],["XP_025181441.2","XP_025174233.1",0.921],["XP_066005796.1","XP_025178501.1",0.939],["XP_066005796.1","XP_025181572.1",0.956],["XP_066005796.1","XP_025182311.1",0.978],["XP_066005796.1","XP_065993956.1",0.946],["XP_066005796.1","XP_025169602.1",0.94],["XP_066005796.1","XP_025174233.1",0.948],["XP_025182311.1","XP_025178501.1",0.955],["XP_025182311.1","XP_025181572.1",0.947],["XP_025182311.1","XP_065993956.1",0.882],["XP_025182311.1","XP_025169602.1",0.907],["XP_025182311.1","XP_025174233.1",0.844],["XP_025169602.1","XP_025174233.1",0.98],["XP_025169602.1","XP_025178501.1",0.754],["XP_025169602.1","XP_025181572.1",0.91],["XP_025169602.1","XP_065993956.1",0.702],["XP_025178501.1","XP_025181572.1",0.544],["XP_025178501.1","XP_065993956.1",0.558],["XP_025178501.1","XP_025174233.1",0.976],["XP_025181572.1","XP_065993956.1",0.898],["XP_025181572.1","XP_025174233.1",0.969],["XP_065993956.1","XP_025174233.1",0.958]],"all_go_terms":{"GO:1901724":1,"GO:1902219":1,"GO:0060567":1,"GO:0006351":3,"GO:0031054":1,"GO:0070934":1,"GO:0010587":1,"GO:0031564":1,"GO:0008615":3,"GO:0006006":1,"GO:0042823":1,"GO:0035606":1,"GO:0006096":1,"GO:0055114":1,"GO:0051402":1,"GO:0009089":1,"GO:0018272":1,"GO:0019518":2,"GO:0019441":2,"GO:0019279":1,"GO:0042853":4,"GO:0006782":2,"GO:0019878":4,"GO:0097053":4,"GO:0033585":2,"GO:0000105":2,"GO:0055089":2,"GO:0009236":2,"GO:0015908":2,"GO:0046511":2,"GO:0019550":2,"GO:0019346":1,"GO:0006523":2,"GO:0051092":1,"GO:0006107":2,"GO:1904831":1,"GO:0009862":2,"GO:0033362":2,"GO:0071269":1,"GO:0009835":2,"GO:0070814":1,"GO:0034276":2,"GO:0042218":2,"GO:0006533":2,"GO:0007219":4,"GO:0019551":2,"GO:0019450":1,"GO:0044524":1,"GO:2001234":1,"GO:0043123":1,"GO:0019343":1,"GO:0009102":2,"GO:0006686":2,"GO:0006783":2,"GO:0006571":2,"GO:0006532":2,"GO:0033512":2,"GO:0032869":2,"GO:1903646":2,"GO:0006986":2,"GO:0015979":2,"GO:0006463":2,"GO:0003085":2,"GO:0070979":2,"GO:0043278":2,"GO:0016576":2,"GO:1902391":2,"GO:0038108":2,"GO:0045842":2,"GO:0000413":2,"GO:1902855":2,"GO:1902325":2,"GO:0030850":2,"GO:0061087":2,"GO:1903071":2,"GO:0035457":2,"GO:0060613":2,"GO:0009736":2,"GO:0035955":2,"GO:0010288":2,"GO:0051291":2,"GO:0009938":2,"GO:1905515":2,"GO:0046661":2,"GO:0051301":2,"GO:0021756":2,"GO:0051607":2,"GO:0031400":2,"GO:0060296":2,"GO:0090526":2,"GO:0070301":2,"GO:0045087":2,"GO:0050689":2,"GO:0031145":2,"GO:1903070":2,"GO:0000492":2,"GO:0007091":2,"GO:1901215":2,"GO:0051348":2,"GO:0036494":2,"GO:0071360":2,"GO:0070389":2,"GO:2000531":2,"GO:0016570":2,"GO:0071276":2,"GO:0000278":2,"GO:0034454":2,"GO:0071357":2,"GO:0046548":2,"GO:2001162":2,"GO:2000324":2,"GO:0006478":2,"GO:1903546":2,"GO:0035845":2,"GO:0034354":2,"GO:0010118":1,"GO:0043420":2,"GO:0006727":1,"GO:0046724":2,"GO:0051384":2,"GO:0019442":2,"GO:0019805":2,"GO:0009436":4,"GO:0006546":2,"GO:0018315":1,"GO:0006564":2,"GO:0070903":2,"GO:0009688":1,"GO:0019700":2,"GO:0044571":2,"GO:0018283":2,"GO:0051591":2,"GO:0042866":2,"GO:0019265":2,"GO:0006777":1,"GO:0019448":2,"GO:0045037":1,"GO:0034516":2,"GO:0006879":1,"GO:0006099":2,"GO:0019679":1,"GO:0009791":1,"GO:0009098":2,"GO:0019298":1,"GO:0009097":3,"GO:0032543":1,"GO:0050892":1,"GO:1990641":1,"GO:0010040":1,"GO:0051661":1,"GO:0045454":1,"GO:0050714":1,"GO:0046890":1,"GO:0008277":1,"GO:0042787":1,"GO:0071909":1,"GO:0048496":1,"GO:0071908":1,"GO:0071492":1,"GO:0008653":1,"GO:0003283":1,"GO:0007346":1,"GO:0030433":1,"GO:0072189":1,"GO:0045070":1,"GO:0001889":1,"GO:1901029":1,"GO:0030435":1,"GO:0009725":1,"GO:0014070":1,"GO:0051260":1,"GO:1902109":1,"GO:0032385":1,"GO:0010111":1,"GO:0006550":1,"GO:0042594":1,"GO:0008203":1,"GO:1902860":1,"GO:0019619":1,"GO:0042619":1,"GO:0046951":1,"GO:0006635":1,"GO:0072229":1,"GO:0007420":1,"GO:0046356":1,"GO:0046952":1,"GO:0060612":1,"GO:1901373":1,"GO:0042867":2,"GO:0000950":2,"GO:0042372":2,"GO:0033611":2,"GO:0019529":2,"GO:0034077":2,"GO:0006086":2,"GO:0009099":2,"GO:0009234":2,"GO:0019655":2,"GO:0019596":2,"GO:0000951":2,"GO:0009851":2,"GO:0022900":2,"GO:0019310":2,"GO:0090180":2,"GO:0000949":2,"GO:0032923":2,"GO:0052314":1,"GO:0019722":1,"GO:0010761":1,"GO:0048085":1,"GO:0033327":1,"GO:0001553":1,"GO:0042412":1,"GO:0043052":1,"GO:0042136":1,"GO:2001120":1,"GO:0051454":1,"GO:0009449":1,"GO:0015842":1,"GO:0033076":1,"GO:0071363":1,"GO:0071312":1,"GO:0035690":1,"GO:0048082":1,"GO:0006587":1,"GO:0007623":1,"GO:0046684":1,"GO:0006538":1,"GO:0006665":1,"GO:0010259":1,"GO:0001694":1,"GO:0006585":1,"GO:0007615":1,"GO:0006097":1,"GO:0006102":1,"GO:0006537":1,"GO:0006103":1,"GO:1904465":1,"GO:0048545":1,"GO:0006749":1,"GO:0008585":1,"GO:0071071":1,"GO:0006740":1,"GO:0006741":1,"GO:0060253":1,"GO:0060696":1,"GO:1903976":1,"GO:0006979":1},"recipe_readded":[]}