{"hash":"939901500336144756","title":"Chromatin remodeling and transcription regulation","description":"This cluster centers on chromatin dynamics and transcriptional machinery, with GO terms for chromatin organization, nucleosome disassembly, histone exchange, H2B ubiquitination, and RNA polymerase II preinitiation complex assembly plus transcription elongation regulation. The heart development terms (atrioventricular canal development, cardiac jelly development) hint at a developmental context, but the dominant signals are chromatin-based control of gene expression. Together, they point to a coordinated role in modulating transcription through chromatin state during development, including cardiac-related processes. Confidence in this theme is High.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"members":[{"accession":"XP_025178367.1","go_terms":["GO:1905072","GO:0036302","GO:0051123"]},{"accession":"XP_025182416.1","go_terms":["GO:0035066","GO:0030466","GO:0032968","GO:0031567","GO:0006348","GO:0033523","GO:0006336","GO:0043486","GO:0006335","GO:0043618","GO:0006337","GO:0001932","GO:0016573"]},{"accession":"XP_065988616.1","go_terms":[]},{"accession":"XP_025165317.1","go_terms":[]},{"accession":"XP_025174766.1","go_terms":[]}],"graph":[["XP_025174766.1","XP_025165317.1",0.512],["XP_025174766.1","XP_025182416.1",0.961],["XP_025174766.1","XP_025178367.1",0.922],["XP_025182416.1","XP_025178367.1",0.965],["XP_025182416.1","XP_065988616.1",0.978],["XP_025182416.1","XP_025165317.1",0.972],["XP_065988616.1","XP_025178367.1",0.958],["XP_065988616.1","XP_025165317.1",0.944],["XP_025165317.1","XP_025178367.1",0.941]],"all_go_terms":{"GO:0036302":1,"GO:1905072":1,"GO:0051123":1,"GO:0006337":1,"GO:0006336":1,"GO:0006335":1,"GO:0031567":1,"GO:0043486":1,"GO:0032968":1,"GO:0033523":1,"GO:0001932":1,"GO:0035066":1,"GO:0006348":1,"GO:0043618":1,"GO:0016573":1,"GO:0030466":1},"recipe_readded":[]}