{"hash":"550208155136954437","title":"Notch receptor processing and signaling","description":"This cluster is dominated by terms related to Notch receptor processing (Notch signaling pathway, Notch receptor processing) and membrane protein proteolysis (ectodomain and intracellular domain proteolysis), along with amyloid-beta formation, which are linked to gamma-secretase\u2013like cleavage common to Notch and APP pathways. Pharynx development supports a developmental Notch role. Some mitochondrial membrane terms appear ancillary noise rather than core themes.","confidence":"Medium","size":18,"edges":34,"triangles":3,"max_degree":12,"top_function":null,"members":[{"accession":"XP_025178637.2","go_terms":["GO:0006626","GO:0007219","GO:0034205","GO:0006509","GO:0007220","GO:0031293","GO:0060465","GO:0007008","GO:0070096"]},{"accession":"XP_025181972.2","go_terms":[]},{"accession":"XP_065994224.1","go_terms":[]},{"accession":"XP_065994959.1","go_terms":[]},{"accession":"XP_066005887.1","go_terms":[]},{"accession":"XP_025182029.1","go_terms":[]},{"accession":"XP_025182783.1","go_terms":["GO:1903061","GO:0061321","GO:0090083","GO:0032435","GO:0090367","GO:0071260","GO:0097192","GO:0010664","GO:0097201","GO:0008625","GO:0051496","GO:0010763","GO:1902176","GO:0031397","GO:2001145","GO:0010228","GO:0042993","GO:0071364","GO:0097178","GO:0046827","GO:0061084","GO:1903215"]},{"accession":"XP_065991742.1","go_terms":["GO:0071494","GO:0071456","GO:0003281","GO:0048096","GO:0006977","GO:0003283","GO:0003139","GO:0003181","GO:0071301","GO:0003203","GO:0000122","GO:0006337","GO:0043044","GO:0003219","GO:0045023","GO:0016567","GO:0043066","GO:1904404","GO:0003407","GO:0007089","GO:0071157","GO:0043518"]},{"accession":"XP_065989169.1","go_terms":[]},{"accession":"XP_065998279.1","go_terms":[]},{"accession":"XP_065995332.1","go_terms":[]},{"accession":"XP_065995477.1","go_terms":["GO:1903212","GO:2001172","GO:0090180","GO:0007527"]},{"accession":"XP_066006327.1","go_terms":[]},{"accession":"XP_025175583.1","go_terms":["GO:0060672","GO:0061436","GO:0060324","GO:0044030","GO:0008544","GO:0061029","GO:0007417","GO:0090103","GO:0007431","GO:0007028","GO:0003208","GO:0001736","GO:0001843","GO:0060463","GO:0051973","GO:0048701","GO:0042060","GO:0002934","GO:0060487","GO:0090132","GO:0042733","GO:0007398","GO:0090179","GO:0070830","GO:0002070","GO:0045617","GO:0043010"]},{"accession":"XP_025186801.1","go_terms":[]},{"accession":"XP_025176023.2","go_terms":[]},{"accession":"XP_065994083.1","go_terms":[]},{"accession":"XP_025170566.1","go_terms":["GO:0006888","GO:0043547","GO:0006914","GO:0016358","GO:0045212"]}],"graph":[["XP_066005887.1","XP_065991742.1",0.579],["XP_066005887.1","XP_065995332.1",0.697],["XP_066005887.1","XP_025176023.2",0.716],["XP_065995332.1","XP_025178637.2",0.793],["XP_065995332.1","XP_025181972.2",0.76],["XP_065995332.1","XP_065994224.1",0.678],["XP_065995332.1","XP_065994959.1",0.749],["XP_025170566.1","XP_065994959.1",0.651],["XP_025186801.1","XP_025181972.2",0.778],["XP_025186801.1","XP_065994959.1",0.773],["XP_065994224.1","XP_025182029.1",0.93],["XP_065994224.1","XP_025182783.1",0.581],["XP_065994224.1","XP_065991742.1",0.694],["XP_065994224.1","XP_065998279.1",0.959],["XP_065994224.1","XP_065995477.1",0.632],["XP_065994224.1","XP_025176023.2",0.904],["XP_025175583.1","XP_025178637.2",0.731],["XP_025175583.1","XP_065994959.1",0.528],["XP_065998279.1","XP_025178637.2",0.933],["XP_065998279.1","XP_065994959.1",0.856],["XP_065994959.1","XP_025181972.2",0.614],["XP_065994959.1","XP_025182029.1",0.942],["XP_065994959.1","XP_065989169.1",0.775],["XP_065994959.1","XP_065991742.1",0.581],["XP_065994959.1","XP_065994083.1",0.614],["XP_065994959.1","XP_065995477.1",0.825],["XP_065994959.1","XP_025176023.2",0.698],["XP_025182029.1","XP_025178637.2",0.873],["XP_025182029.1","XP_025181972.2",0.901],["XP_065995477.1","XP_025178637.2",0.604],["XP_065989169.1","XP_025178637.2",0.797],["XP_025178637.2","XP_025182783.1",0.856],["XP_025178637.2","XP_065991742.1",0.531],["XP_025178637.2","XP_066006327.1",0.526]],"all_go_terms":{"GO:0006509":1,"GO:0006626":1,"GO:0031293":1,"GO:0070096":1,"GO:0060465":1,"GO:0007220":1,"GO:0007219":1,"GO:0034205":1,"GO:0007008":1,"GO:1903215":1,"GO:0090367":1,"GO:0097192":1,"GO:0010763":1,"GO:0031397":1,"GO:0046827":1,"GO:0042993":1,"GO:0097201":1,"GO:1903061":1,"GO:0061321":1,"GO:0008625":1,"GO:0032435":1,"GO:1902176":1,"GO:0071364":1,"GO:0051496":1,"GO:0097178":1,"GO:0010664":1,"GO:0061084":1,"GO:0071260":1,"GO:0090083":1,"GO:2001145":1,"GO:0010228":1,"GO:0045023":1,"GO:0071494":1,"GO:0071157":1,"GO:0003181":1,"GO:0071301":1,"GO:0043518":1,"GO:0000122":1,"GO:0003219":1,"GO:0007089":1,"GO:0006337":1,"GO:0003407":1,"GO:0071456":1,"GO:0043066":1,"GO:0048096":1,"GO:0003281":1,"GO:0003283":1,"GO:0016567":1,"GO:0003203":1,"GO:0003139":1,"GO:1904404":1,"GO:0006977":1,"GO:0043044":1,"GO:2001172":1,"GO:0090180":1,"GO:0007527":1,"GO:1903212":1,"GO:0061436":1,"GO:0007431":1,"GO:0007398":1,"GO:0007417":1,"GO:0002934":1,"GO:0042060":1,"GO:0042733":1,"GO:0001736":1,"GO:0060487":1,"GO:0007028":1,"GO:0051973":1,"GO:0002070":1,"GO:0060324":1,"GO:0090132":1,"GO:0044030":1,"GO:0070830":1,"GO:0061029":1,"GO:0090179":1,"GO:0045617":1,"GO:0008544":1,"GO:0060463":1,"GO:0001843":1,"GO:0048701":1,"GO:0060672":1,"GO:0090103":1,"GO:0043010":1,"GO:0003208":1,"GO:0006914":1,"GO:0006888":1,"GO:0043547":1,"GO:0045212":1,"GO:0016358":1},"recipe_readded":[]}