{"hash":"425986259291345334","title":"Ubiquitin-Proteasome Regulation and Stress Response","description":"Proteostasis and stress-response cluster dominated by ubiquitination and proteasome pathways, with secondary links to DNA damage control, circadian regulation, and neuronal stress. The prominent GO terms\u2014positive regulation of polyubiquitination, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process\u2014point to a core ubiquitin\u2013proteasome system module. Additional terms for circadian rhythm regulation and mitotic DNA damage checkpoint signaling suggest coordination between cell cycle, timing, and stress responses. The presence of cellular responses to cadmium and methylmercury, as well as oxidative stress\u2013induced neuronal apoptotic signaling and synapse assembly, expands this into neuronal stress signaling and synaptic remodeling context. Overall, the cluster appears to capture proteostasis coupled with cellular stress responses, particularly in neural-related processes.","confidence":"High","size":26,"edges":316,"triangles":2403,"max_degree":25,"top_function":null,"members":[{"accession":"XP_025184135.1","go_terms":[]},{"accession":"XP_065988647.1","go_terms":[]},{"accession":"XP_065988835.1","go_terms":[]},{"accession":"XP_065992798.1","go_terms":[]},{"accession":"XP_066000134.1","go_terms":[]},{"accession":"XP_066001102.1","go_terms":[]},{"accession":"XP_025165632.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_025170634.2","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_025181562.2","go_terms":[]},{"accession":"XP_065993182.1","go_terms":[]},{"accession":"XP_065994471.1","go_terms":[]},{"accession":"XP_065995215.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065996284.1","go_terms":[]},{"accession":"XP_065998789.1","go_terms":[]},{"accession":"XP_066000418.1","go_terms":[]},{"accession":"XP_025181325.2","go_terms":[]},{"accession":"XP_065988912.1","go_terms":[]},{"accession":"XP_066000627.1","go_terms":[]},{"accession":"XP_066003170.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066003223.1","go_terms":[]},{"accession":"XP_025171915.2","go_terms":[]},{"accession":"XP_025183513.2","go_terms":[]},{"accession":"XP_025188620.2","go_terms":[]},{"accession":"XP_065993181.1","go_terms":[]},{"accession":"XP_066001063.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066001426.1","go_terms":[]}],"graph":[["XP_066001102.1","XP_025181325.2",0.963],["XP_066001102.1","XP_025181562.2",0.963],["XP_066001102.1","XP_025183513.2",0.86],["XP_066001102.1","XP_025184135.1",0.963],["XP_066001102.1","XP_025188620.2",0.964],["XP_066001102.1","XP_065988647.1",0.86],["XP_066001102.1","XP_065988835.1",0.86],["XP_066001102.1","XP_065988912.1",0.964],["XP_066001102.1","XP_065992798.1",0.964],["XP_066001102.1","XP_065993181.1",0.962],["XP_066001102.1","XP_065994471.1",0.962],["XP_066001102.1","XP_065995215.1",0.963],["XP_066001102.1","XP_065996284.1",0.963],["XP_066001102.1","XP_065998789.1",0.685],["XP_066001102.1","XP_066000134.1",0.861],["XP_066001102.1","XP_066000418.1",0.964],["XP_066001102.1","XP_066000627.1",0.964],["XP_066001102.1","XP_066003170.1",0.86],["XP_066001102.1","XP_066003223.1",0.963],["XP_066001102.1","XP_066001063.1",0.963],["XP_066001102.1","XP_066001426.1",0.964],["XP_066001102.1","XP_025165632.1",0.685],["XP_066001102.1","XP_025170634.2",0.859],["XP_066001102.1","XP_025171915.2",0.86],["XP_065994471.1","XP_025181325.2",0.909],["XP_065994471.1","XP_025181562.2",0.934],["XP_065994471.1","XP_025183513.2",0.859],["XP_065994471.1","XP_025184135.1",0.822],["XP_065994471.1","XP_025188620.2",0.961],["XP_065994471.1","XP_065988647.1",0.953],["XP_065994471.1","XP_065988835.1",0.962],["XP_065994471.1","XP_065988912.1",0.96],["XP_065994471.1","XP_065992798.1",0.962],["XP_065994471.1","XP_065993181.1",0.677],["XP_065994471.1","XP_065993182.1",0.855],["XP_065994471.1","XP_065998789.1",0.951],["XP_065994471.1","XP_065996284.1",0.941],["XP_065994471.1","XP_065995215.1",0.897],["XP_065994471.1","XP_066003170.1",0.852],["XP_065994471.1","XP_066003223.1",0.695],["XP_065994471.1","XP_066001426.1",0.843],["XP_065994471.1","XP_066001063.1",0.854],["XP_065994471.1","XP_066000134.1",0.709],["XP_065994471.1","XP_066000418.1",0.958],["XP_065994471.1","XP_066000627.1",0.808],["XP_065994471.1","XP_025165632.1",0.745],["XP_065994471.1","XP_025170634.2",0.831],["XP_065994471.1","XP_025171915.2",0.669],["XP_065992798.1","XP_025181325.2",0.963],["XP_065992798.1","XP_025181562.2",0.963],["XP_065992798.1","XP_025183513.2",0.963],["XP_065992798.1","XP_025184135.1",0.963],["XP_065992798.1","XP_025188620.2",0.963],["XP_065992798.1","XP_065988647.1",0.963],["XP_065992798.1","XP_065988835.1",0.86],["XP_065992798.1","XP_065988912.1",0.86],["XP_065992798.1","XP_065993181.1",0.963],["XP_065992798.1","XP_065993182.1",0.861],["XP_065992798.1","XP_065998789.1",0.963],["XP_065992798.1","XP_065996284.1",0.963],["XP_065992798.1","XP_065995215.1",0.963],["XP_065992798.1","XP_066003170.1",0.963],["XP_065992798.1","XP_066003223.1",0.963],["XP_065992798.1","XP_066001426.1",0.964],["XP_065992798.1","XP_066001063.1",0.963],["XP_065992798.1","XP_066000134.1",0.963],["XP_065992798.1","XP_066000418.1",0.86],["XP_065992798.1","XP_066000627.1",0.963],["XP_065992798.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