{"hash":"296507352428598648","title":"Ubiquitin-Proteasome Regulation with Circadian and Stress Response","description":"The cluster is enriched for ubiquitination and proteasomal degradation terms (positive regulation of polyubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process), plus regulation of circadian rhythm and stress-response pathways (cadmium and methylmercury exposure, oxidative stress-related neuronal signaling). This points to a cohesive theme centered on proteostasis via ubiquitin-proteasome pathways, intertwined with circadian control and cellular stress responses, justifying the label.","confidence":"Medium","size":28,"edges":13,"triangles":0,"max_degree":4,"top_function":null,"members":[{"accession":"XP_025178663.2","go_terms":[]},{"accession":"XP_025181319.2","go_terms":[]},{"accession":"XP_025184105.1","go_terms":[]},{"accession":"XP_025187631.1","go_terms":[]},{"accession":"XP_025189679.1","go_terms":[]},{"accession":"XP_065995243.1","go_terms":[]},{"accession":"XP_065995256.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065999245.1","go_terms":[]},{"accession":"XP_025168277.2","go_terms":[]},{"accession":"XP_025169891.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065989771.1","go_terms":[]},{"accession":"XP_065991102.1","go_terms":[]},{"accession":"XP_025181346.1","go_terms":[]},{"accession":"XP_025183905.2","go_terms":[]},{"accession":"XP_025184327.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065993489.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066001104.1","go_terms":[]},{"accession":"XP_066003729.1","go_terms":[]},{"accession":"XP_066004362.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_025173180.2","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066004200.1","go_terms":[]},{"accession":"XP_025173947.2","go_terms":[]},{"accession":"XP_065997213.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066000626.1","go_terms":[]},{"accession":"XP_066000630.1","go_terms":[]},{"accession":"XP_025165643.2","go_terms":[]},{"accession":"XP_065996555.1","go_terms":[]},{"accession":"XP_066001385.1","go_terms":[]}],"graph":[["XP_025189679.1","XP_025178663.2",0.735],["XP_025189679.1","XP_065993489.1",0.579],["XP_025181319.2","XP_065995243.1",0.765],["XP_025181319.2","XP_065995256.1",0.64],["XP_065996555.1","XP_066001104.1",0.812],["XP_065991102.1","XP_025184327.1",0.712],["XP_025178663.2","XP_025187631.1",0.762],["XP_025178663.2","XP_025165643.2",0.559],["XP_025178663.2","XP_025168277.2",0.63],["XP_025181346.1","XP_066001104.1",0.532],["XP_066004362.1","XP_065995243.1",0.57],["XP_065993489.1","XP_025165643.2",0.572],["XP_065993489.1","XP_025173180.2",0.61]],"all_go_terms":{"GO:1902916":7,"GO:0030174":7,"GO:0042752":7,"GO:0031146":7,"GO:1903378":7,"GO:0071276":7,"GO:0031571":7,"GO:0000083":7,"GO:0071406":7,"GO:0060386":7,"GO:0000209":7,"GO:0046685":7,"GO:0042787":7},"recipe_readded":["XP_025185133.1","XP_025173459.1","XP_025185134.2","XP_066000628.1","XP_066000972.1","XP_025187106.1","XP_066005526.1","XP_025175830.1","XP_025173441.1","XP_065993496.1","XP_025173870.1","XP_066004354.1","XP_065998869.1","XP_025166325.1","XP_065998787.1","XP_025183859.1","XP_065989696.1","XP_025174018.2","XP_025177249.2","XP_065993497.1"]}