{"hash":"270007725049995175","title":"Ubiquitin-Mediated Proteostasis and Stress Signaling","description":"This cluster is dominated by GO terms for ubiquitin-proteasome\u2013dependent protein turnover (positive regulation of polyubiquitination, SCF-dependent proteolysis) and cell-cycle regulation (DNA replication initiation, G1/S checkpoint). Additional terms link to circadian rhythm control and various stress responses (heavy metals, oxidative stress) in neurons, plus synapse assembly, suggesting a cohesive theme of regulated proteostasis and stress-responsive cell-cycle and neuronal signaling.","confidence":"Medium","size":15,"edges":15,"triangles":1,"max_degree":5,"top_function":null,"members":[{"accession":"XP_065996589.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066000439.1","go_terms":[]},{"accession":"XP_066001424.1","go_terms":[]},{"accession":"XP_066004550.1","go_terms":[]},{"accession":"XP_025170379.1","go_terms":[]},{"accession":"XP_025187416.2","go_terms":[]},{"accession":"XP_066001357.1","go_terms":[]},{"accession":"XP_025174018.2","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_025177249.2","go_terms":[]},{"accession":"XP_025183859.1","go_terms":[]},{"accession":"XP_025166325.1","go_terms":[]},{"accession":"XP_025170940.2","go_terms":[]},{"accession":"XP_025181004.2","go_terms":[]},{"accession":"XP_065994146.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066002877.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]}],"graph":[["XP_066001424.1","XP_025177249.2",0.941],["XP_066001424.1","XP_066004550.1",0.864],["XP_066001424.1","XP_025166325.1",0.612],["XP_066001424.1","XP_025170940.2",0.652],["XP_025174018.2","XP_025183859.1",0.581],["XP_025183859.1","XP_066002877.1",0.764],["XP_025183859.1","XP_066004550.1",0.52],["XP_025170940.2","XP_065996589.1",0.794],["XP_025181004.2","XP_025177249.2",0.719],["XP_065996589.1","XP_066004550.1",0.661],["XP_066001357.1","XP_066002877.1",0.52],["XP_065994146.1","XP_025177249.2",0.512],["XP_065994146.1","XP_066004550.1",0.56],["XP_066002877.1","XP_025177249.2",0.526],["XP_066002877.1","XP_066004550.1",0.86]],"all_go_terms":{"GO:1902916":4,"GO:0030174":4,"GO:0042752":4,"GO:0031146":4,"GO:1903378":4,"GO:0071276":4,"GO:0031571":4,"GO:0000083":4,"GO:0071406":4,"GO:0060386":4,"GO:0000209":4,"GO:0046685":4,"GO:0042787":4},"recipe_readded":[]}