{"hash":"2222365272433841886","title":"Ubiquitination-driven proteostasis and cell cycle regulation","description":"The cluster shows strong enrichment for ubiquitin-related processes (positive regulation of polyubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process) and cell-cycle control signals (regulation of DNA-templated DNA replication initiation; mitotic G1 DNA damage checkpoint signaling). Additional terms point to circadian rhythm regulation and various stress responses (metal ions, oxidative stress in neurons) as well as neuronal development (synapse assembly), suggesting a core module where protein turnover and cell-cycle/DNA damage regulation interface with broader stress-response pathways. This makes the ubiquitination-proteostasis and cell-cycle regulation theme the most representative shared function.","confidence":"Medium","size":11,"edges":35,"triangles":48,"max_degree":10,"top_function":null,"members":[{"accession":"XP_065993482.1","go_terms":[]},{"accession":"XP_066000625.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066001390.1","go_terms":[]},{"accession":"XP_066003672.1","go_terms":[]},{"accession":"XP_065988153.1","go_terms":[]},{"accession":"XP_065992144.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065992763.1","go_terms":[]},{"accession":"XP_066001201.1","go_terms":[]},{"accession":"XP_066001238.1","go_terms":[]},{"accession":"XP_025178702.1","go_terms":[]},{"accession":"XP_066001065.1","go_terms":[]}],"graph":[["XP_066003672.1","XP_065988153.1",0.706],["XP_066003672.1","XP_065992144.1",0.55],["XP_066003672.1","XP_065993482.1",0.568],["XP_066003672.1","XP_066000625.1",0.54],["XP_066003672.1","XP_066001065.1",0.629],["XP_066003672.1","XP_066001201.1",0.597],["XP_066003672.1","XP_066001390.1",0.537],["XP_066001238.1","XP_065988153.1",0.545],["XP_066001238.1","XP_065993482.1",0.529],["XP_066001238.1","XP_066000625.1",0.586],["XP_066001238.1","XP_066001065.1",0.802],["XP_066001238.1","XP_066001201.1",0.545],["XP_066001201.1","XP_065988153.1",0.932],["XP_066001201.1","XP_065992144.1",0.84],["XP_066001201.1","XP_065992763.1",0.715],["XP_066001201.1","XP_066000625.1",0.932],["XP_065993482.1","XP_025178702.1",0.963],["XP_065993482.1","XP_065988153.1",0.961],["XP_065993482.1","XP_065992144.1",0.527],["XP_065993482.1","XP_065992763.1",0.681],["XP_065993482.1","XP_066000625.1",0.838],["XP_065993482.1","XP_066001065.1",0.503],["XP_066001065.1","XP_025178702.1",0.961],["XP_066001065.1","XP_065988153.1",0.857],["XP_066001065.1","XP_066000625.1",0.839],["XP_025178702.1","XP_065988153.1",0.94],["XP_025178702.1","XP_066000625.1",0.648],["XP_066000625.1","XP_065988153.1",0.779],["XP_066000625.1","XP_065992144.1",0.912],["XP_066000625.1","XP_065992763.1",0.608],["XP_066001390.1","XP_065988153.1",0.685],["XP_066001390.1","XP_065992144.1",0.54],["XP_065992763.1","XP_065988153.1",0.585],["XP_065992763.1","XP_065992144.1",0.608],["XP_065992144.1","XP_065988153.1",0.835]],"all_go_terms":{"GO:1902916":2,"GO:0030174":2,"GO:0042752":2,"GO:0031146":2,"GO:1903378":2,"GO:0071276":2,"GO:0031571":2,"GO:0000083":2,"GO:0071406":2,"GO:0060386":2,"GO:0000209":2,"GO:0046685":2,"GO:0042787":2},"recipe_readded":[]}