{"hash":"2211241615135870989","title":"Ubiquitin-regulated proteostasis and stress signaling","description":"The top terms cluster around ubiquitin-mediated protein turnover (polyubiquitination, SCF-dependent proteasomal degradation), regulation of cell cycle and DNA damage checkpoint signaling, and circadian rhythm control, with additional annotations for metal-induced stress responses (cadmium, methylmercury) and neuronal stress pathways including synapse assembly. This suggests a cohesive theme of proteostasis intersecting with stress signaling, hence a label focused on ubiquitin-regulated proteostasis and stress signaling.","confidence":"Medium","size":11,"edges":35,"triangles":48,"max_degree":9,"top_function":null,"members":[{"accession":"XP_025177807.1","go_terms":[]},{"accession":"XP_065998763.1","go_terms":[]},{"accession":"XP_065998848.1","go_terms":[]},{"accession":"XP_025166322.1","go_terms":[]},{"accession":"XP_025175665.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065992821.1","go_terms":[]},{"accession":"XP_065994478.1","go_terms":[]},{"accession":"XP_066001182.1","go_terms":[]},{"accession":"XP_066001434.1","go_terms":[]},{"accession":"XP_066004358.1","go_terms":[]},{"accession":"XP_065997324.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]}],"graph":[["XP_025175665.1","XP_025166322.1",0.853],["XP_025175665.1","XP_025177807.1",0.888],["XP_025175665.1","XP_065998848.1",0.852],["XP_025175665.1","XP_065998763.1",0.928],["XP_025175665.1","XP_065997324.1",0.96],["XP_025175665.1","XP_066004358.1",0.955],["XP_025175665.1","XP_066001434.1",0.798],["XP_025175665.1","XP_066001182.1",0.566],["XP_025166322.1","XP_025177807.1",0.818],["XP_025166322.1","XP_065998848.1",0.706],["XP_025166322.1","XP_065998763.1",0.749],["XP_025166322.1","XP_065997324.1",0.685],["XP_025166322.1","XP_066004358.1",0.958],["XP_025166322.1","XP_066001182.1",0.672],["XP_066001434.1","XP_025177807.1",0.894],["XP_066001434.1","XP_065994478.1",0.521],["XP_066001434.1","XP_065997324.1",0.859],["XP_066001434.1","XP_066001182.1",0.786],["XP_066001434.1","XP_066004358.1",0.669],["XP_066001182.1","XP_025177807.1",0.93],["XP_066001182.1","XP_065994478.1",0.63],["XP_066001182.1","XP_065998763.1",0.897],["XP_066001182.1","XP_066004358.1",0.659],["XP_065998848.1","XP_025177807.1",0.934],["XP_065998848.1","XP_065997324.1",0.87],["XP_065998848.1","XP_066004358.1",0.853],["XP_065997324.1","XP_025177807.1",0.684],["XP_065997324.1","XP_065992821.1",0.679],["XP_065997324.1","XP_065994478.1",0.918],["XP_065997324.1","XP_065998763.1",0.685],["XP_065994478.1","XP_066004358.1",0.901],["XP_066004358.1","XP_025177807.1",0.962],["XP_066004358.1","XP_065998763.1",0.859],["XP_025177807.1","XP_065992821.1",0.891],["XP_025177807.1","XP_065998763.1",0.834]],"all_go_terms":{"GO:1902916":2,"GO:0030174":2,"GO:0042752":2,"GO:0031146":2,"GO:1903378":2,"GO:0071276":2,"GO:0031571":2,"GO:0000083":2,"GO:0071406":2,"GO:0060386":2,"GO:0000209":2,"GO:0046685":2,"GO:0042787":2},"recipe_readded":[]}