{"hash":"2073580273682488833","title":"Ubiquitin-Proteasome-Mediated Protein Degradation","description":"This cluster is dominated by GO terms describing ubiquitin-dependent protein catabolic processes, including SCF-dependent ubiquitination, ubiquitin-linked degradation via ERAD, and autoubiquitination, pointing to a core proteostasis module. A few terms such as TNF signaling and photomorphogenesis appear context-specific, but the shared theme is tagging substrates for proteasomal degradation and turnover.","confidence":"High","size":26,"edges":76,"triangles":92,"max_degree":15,"top_function":null,"members":[{"accession":"XP_025170734.2","go_terms":["GO:2000342","GO:0060263","GO:0016332","GO:0045630","GO:0021744","GO:0098779","GO:0035023","GO:0035089","GO:0031139","GO:2000664","GO:2000667","GO:2000769","GO:2001181","GO:2000553","GO:0035778","GO:0016236","GO:2000353","GO:1904781","GO:0010310","GO:0045217","GO:0061635","GO:0060252","GO:0070375","GO:0007502","GO:0045415","GO:0034351","GO:1900745","GO:0032005"]},{"accession":"XP_025189042.1","go_terms":["GO:0032436","GO:0070911","GO:0034126","GO:0090204","GO:0010286","GO:1901896","GO:0071276","GO:0043392","GO:0060334","GO:0051572","GO:0016925","GO:0043433","GO:0035186","GO:0086004","GO:0030578","GO:1902260","GO:0045944","GO:0045759","GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412"]},{"accession":"XP_025189638.1","go_terms":[]},{"accession":"XP_025179044.1","go_terms":[]},{"accession":"XP_025179486.1","go_terms":[]},{"accession":"XP_025179877.2","go_terms":[]},{"accession":"XP_025185960.2","go_terms":[]},{"accession":"XP_065988809.1","go_terms":[]},{"accession":"XP_065995412.1","go_terms":[]},{"accession":"XP_066000424.1","go_terms":[]},{"accession":"XP_066002673.1","go_terms":[]},{"accession":"XP_066004422.1","go_terms":["GO:1990451","GO:0071264","GO:0031953","GO:1990497","GO:0060733","GO:0097201","GO:0070301","GO:1902073","GO:0033235","GO:0071494","GO:0072755","GO:1990253","GO:1990138","GO:0071232","GO:0031333","GO:1903833","GO:0042149","GO:0036492","GO:0060765","GO:1904803","GO:0000077","GO:0071468"]},{"accession":"XP_066005330.1","go_terms":[]},{"accession":"XP_025164942.1","go_terms":[]},{"accession":"XP_025165659.1","go_terms":[]},{"accession":"XP_025165661.1","go_terms":[]},{"accession":"XP_025166101.1","go_terms":["GO:0051001","GO:0009640","GO:0045087","GO:0009896","GO:0046007","GO:1902187","GO:0035372","GO:0030433","GO:0000185","GO:0061470","GO:0046597","GO:1901224","GO:0033280","GO:0007026","GO:0042098","GO:0043029","GO:1903886","GO:1903883","GO:0048536","GO:0045623","GO:0048535","GO:0070534","GO:0043123","GO:0050999","GO:1903265","GO:0060546","GO:0006914","GO:0001782","GO:0002635","GO:0048490","GO:0032897","GO:0007014","GO:0051092","GO:0097039","GO:0051607","GO:0061158","GO:0031664"]},{"accession":"XP_025166908.2","go_terms":["GO:1901487","GO:0032020","GO:0042138","GO:0010390","GO:0043951","GO:0090089","GO:0030509","GO:0043524","GO:0051569","GO:0031058","GO:0070936","GO:0006303","GO:0000086","GO:0035666","GO:0070534","GO:0043123","GO:1903955","GO:0010976","GO:0007288","GO:0031505","GO:0070423","GO:0070987","GO:0051865","GO:0016562","GO:0031497","GO:0051026","GO:0070911","GO:1902426","GO:0010620","GO:1990920","GO:0045116","GO:0031571","GO:0070459","GO:0071455","GO:0071596","GO:0033128","GO:0006348","GO:0007059","GO:0042276","GO:0038095","GO:0070193","GO:1901694","GO:0051443","GO:0071347","GO:0016558","GO:0085020","GO:0051965","GO:0045739","GO:0030466","GO:0031939","GO:0010845","GO:0006344","GO:0000722","GO:0007254","GO:0001701","GO:0042275","GO:0000724","GO:0070979","GO:0000729","GO:0060340","GO:1902916","GO:1904153","GO:1901044","GO:0010994","GO:0002223","GO:0031146","GO:0031145","GO:0045141","GO:0051092","GO:0044314","GO:0070076","GO:0070059","GO:0061186","GO:0071894","GO:0035519","GO:1903755","GO:0035458","GO:0000022","GO:0051301","GO:0009737","GO:0071629","GO:0050852","GO:0000278","GO:0006915","GO:0030433","GO:0033182","GO:0010458","GO:0016032"]},{"accession":"XP_025168039.1","go_terms":[]},{"accession":"XP_025170504.2","go_terms":["GO:0006295","GO:0006294","GO:0006296","GO:0045116","GO:0010265","GO:0043162","GO:0000717","GO:0006293","GO:0000715","GO:0016567","GO:1902104","GO:0042769","GO:0016032","GO:0051759","GO:0031146","GO:0070911","GO:0070979","GO:0042787","GO:0031145","GO:0051301"]},{"accession":"XP_025172171.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_025174875.1","go_terms":[]},{"accession":"XP_025175832.1","go_terms":[]},{"accession":"XP_025182437.1","go_terms":["GO:0035518","GO:0031286","GO:0000086","GO:0048825","GO:0030154","GO:0000082","GO:0007295","GO:0051759","GO:2000819","GO:0044346","GO:0010100","GO:0001701","GO:0070979","GO:0048575","GO:0051232","GO:1903467","GO:0030853","GO:0042787","GO:0043149","GO:0000278","GO:0008283","GO:0031146","GO:0035019","GO:0050775","GO:0072576","GO:0007399","GO:0040016","GO:0001831","GO:0045773","GO:0031915","GO:1902104","GO:2000001","GO:0030097","GO:1900087","GO:0035024","GO:0019102","GO:0009640","GO:0017145"]},{"accession":"XP_025182802.1","go_terms":[]},{"accession":"XP_066000436.1","go_terms":[]}],"graph":[["XP_025179877.2","XP_066004422.1",0.86],["XP_066000424.1","XP_025189638.1",0.861],["XP_066000424.1","XP_025166908.2",0.619],["XP_066000424.1","XP_025170734.2",0.834],["XP_025174875.1","XP_025166908.2",0.532],["XP_025174875.1","XP_025170504.2",0.937],["XP_025174875.1","XP_025182437.1",0.86],["XP_025174875.1","XP_066004422.1",0.686],["XP_025170734.2","XP_025164942.1",0.938],["XP_025170734.2","XP_025165661.1",0.859],["XP_025170734.2","XP_025166908.2",0.683],["XP_025170734.2","XP_025168039.1",0.683],["XP_025170734.2","XP_025179044.1",0.667],["XP_025170734.2","XP_025179486.1",0.603],["XP_025170734.2","XP_025185960.2",0.824],["XP_025170734.2","XP_025189042.1",0.978],["XP_025170734.2","XP_025189638.1",0.94],["XP_025170734.2","XP_065988809.1",0.509],["XP_025170734.2","XP_066004422.1",0.647],["XP_025170734.2","XP_066005330.1",0.858],["XP_025164942.1","XP_025165661.1",0.86],["XP_025164942.1","XP_025166101.1",0.938],["XP_025164942.1","XP_025166908.2",0.799],["XP_025164942.1","XP_025168039.1",0.938],["XP_025164942.1","XP_025170504.2",0.958],["XP_025164942.1","XP_025179044.1",0.517],["XP_025164942.1","XP_025179486.1",0.954],["XP_025164942.1","XP_025185960.2",0.52],["XP_025164942.1","XP_025189042.1",0.844],["XP_025164942.1","XP_025189638.1",0.86],["XP_025164942.1","XP_065988809.1",0.86],["XP_025164942.1","XP_065995412.1",0.548],["XP_025164942.1","XP_066002673.1",0.529],["XP_025164942.1","XP_066004422.1",0.527],["XP_025170504.2","XP_025166101.1",0.909],["XP_025170504.2","XP_025166908.2",0.987],["XP_025170504.2","XP_025168039.1",0.973],["XP_025170504.2","XP_025172171.1",0.858],["XP_025170504.2","XP_025175832.1",0.858],["XP_025170504.2","XP_025179044.1",0.937],["XP_025170504.2","XP_025179486.1",0.858],["XP_025170504.2","XP_025182437.1",0.937],["XP_025170504.2","XP_025189042.1",0.948],["XP_025170504.2","XP_025189638.1",0.936],["XP_025170504.2","XP_065995412.1",0.851],["XP_025170504.2","XP_066004422.1",0.96],["XP_025182437.1","XP_025179486.1",0.912],["XP_025182437.1","XP_025185960.2",0.829],["XP_025182437.1","XP_025189042.1",0.859],["XP_025182437.1","XP_065988809.1",0.885],["XP_025182437.1","XP_025165659.1",0.685],["XP_065995412.1","XP_025179044.1",0.803],["XP_065995412.1","XP_025189042.1",0.754],["XP_065995412.1","XP_025166908.2",0.5],["XP_025168039.1","XP_025189042.1",0.858],["XP_025168039.1","XP_025189638.1",0.939],["XP_025168039.1","XP_066004422.1",0.86],["XP_065988809.1","XP_066004422.1",0.86],["XP_065988809.1","XP_025166908.2",0.748],["XP_066005330.1","XP_025166101.1",0.858],["XP_066005330.1","XP_025166908.2",0.859],["XP_025179486.1","XP_025189638.1",0.939],["XP_025179486.1","XP_066004422.1",0.86],["XP_025179486.1","XP_025166908.2",0.964],["XP_025179044.1","XP_025189042.1",0.741],["XP_025179044.1","XP_066004422.1",0.503],["XP_025189638.1","XP_025185960.2",0.939],["XP_025189638.1","XP_025189042.1",0.857],["XP_025189638.1","XP_025166908.2",0.915],["XP_025165661.1","XP_066004422.1",0.86],["XP_066002673.1","XP_025189042.1",0.852],["XP_025165659.1","XP_066004422.1",0.86],["XP_025166908.2","XP_025166101.1",0.504],["XP_025166908.2","XP_025189042.1",0.962],["XP_066004422.1","XP_025189042.1",0.64],["XP_025166101.1","XP_025189042.1",0.934]],"all_go_terms":{"GO:2001181":1,"GO:0021744":1,"GO:0035023":1,"GO:0016236":1,"GO:2000342":1,"GO:2000769":1,"GO:0035089":1,"GO:2000353":1,"GO:1900745":1,"GO:2000664":1,"GO:0098779":1,"GO:0045415":1,"GO:2000667":1,"GO:0010310":1,"GO:0035778":1,"GO:0034351":1,"GO:0016332":1,"GO:0031139":1,"GO:0032005":1,"GO:0060263":1,"GO:0045630":1,"GO:0045217":1,"GO:1904781":1,"GO:0061635":1,"GO:2000553":1,"GO:0070375":1,"GO:0007502":1,"GO:0060252":1,"GO:0090204":1,"GO:1901340":1,"GO:1901097":1,"GO:0000753":1,"GO:0071816":1,"GO:1902236":1,"GO:0070842":1,"GO:0014070":1,"GO:1904378":1,"GO:0034126":1,"GO:0006517":1,"GO:0017085":1,"GO:0021888":1,"GO:0051865":2,"GO:0030578":1,"GO:0043433":1,"GO:0086004":1,"GO:1903071":1,"GO:0097237":1,"GO:1901896":1,"GO:0045648":1,"GO:1900186":1,"GO:0000028":1,"GO:1904049":1,"GO:0010636":1,"GO:0030474":1,"GO:0002109":1,"GO:1902283":1,"GO:0032436":1,"GO:0034140":1,"GO:0010637":1,"GO:0000423":1,"GO:0045944":1,"GO:0006357":1,"GO:1905366":1,"GO:1902260":1,"GO:0043392":1,"GO:0016579":1,"GO:0045759":1,"GO:0016925":1,"GO:1903265":2,"GO:0010216":1,"GO:0071276":2,"GO:0051572":1,"GO:0010286":1,"GO:1904021":1,"GO:0006289":1,"GO:0060334":1,"GO:0006412":1,"GO:0035186":1,"GO:0033132":1,"GO:0030433":3,"GO:1901799":1,"GO:0035973":1,"GO:0070911":3,"GO:0031953":1,"GO:0060733":1,"GO:0071494":1,"GO:1990451":1,"GO:0000077":1,"GO:1990497":1,"GO:1990138":1,"GO:1990253":1,"GO:1904803":1,"GO:0097201":1,"GO:0042149":1,"GO:0031333":1,"GO:0033235":1,"GO:0072755":1,"GO:0071468":1,"GO:0070301":1,"GO:0071264":1,"GO:0036492":1,"GO:1902073":1,"GO:1903833":1,"GO:0060765":1,"GO:0071232":1,"GO:0042098":1,"GO:1901224":1,"GO:0035372":1,"GO:0009640":2,"GO:0007014":1,"GO:0048490":1,"GO:0009896":1,"GO:1903886":1,"GO:0051092":2,"GO:0002635":1,"GO:0061470":1,"GO:1902187":1,"GO:0045623":1,"GO:0050999":1,"GO:0032897":1,"GO:1903883":1,"GO:0006914":1,"GO:0051607":1,"GO:0001782":1,"GO:0060546":1,"GO:0051001":1,"GO:0033280":1,"GO:0097039":1,"GO:0045087":1,"GO:0048536":1,"GO:0000185":1,"GO:0031664":1,"GO:0070534":2,"GO:0048535":1,"GO:0043123":2,"GO:0046007":1,"GO:0061158":1,"GO:0043029":1,"GO:0046597":1,"GO:0007026":1,"GO:0042275":1,"GO:0043524":1,"GO:0044314":1,"GO:0016558":1,"GO:0031505":1,"GO:0051026":1,"GO:0016562":1,"GO:0042138":1,"GO:1903755":1,"GO:0085020":1,"GO:0070423":1,"GO:0031571":2,"GO:1990920":1,"GO:1901044":1,"GO:0000022":1,"GO:0050852":1,"GO:0070076":1,"GO:0010458":1,"GO:0000729":1,"GO:1901487":1,"GO:0071894":1,"GO:0061186":1,"GO:0045116":2,"GO:0032020":1,"GO:0035519":1,"GO:0031146":4,"GO:0051443":1,"GO:0035666":1,"GO:0045141":1,"GO:0038095":1,"GO:0051569":1,"GO:0051965":1,"GO:0060340":1,"GO:0010994":1,"GO:1903955":1,"GO:0002223":1,"GO:0016032":2,"GO:0070936":1,"GO:0000724":1,"GO:0006348":1,"GO:0000722":1,"GO:1902916":2,"GO:0070459":1,"GO:0006344":1,"GO:0071596":1,"GO:0010390":1,"GO:0007288":1,"GO:0031145":2,"GO:0001701":2,"GO:0033128":1,"GO:0043951":1,"GO:0009737":1,"GO:0000086":2,"GO:0031939":1,"GO:0045739":1,"GO:1901694":1,"GO:0071629":1,"GO:0070979":3,"GO:0033182":1,"GO:0010845":1,"GO:0006915":1,"GO:0070193":1,"GO:0070987":1,"GO:0010620":1,"GO:0031058":1,"GO:0042276":1,"GO:0035458":1,"GO:0030466":1,"GO:0031497":1,"GO:1904153":1,"GO:0051301":2,"GO:0006303":1,"GO:0071455":1,"GO:0007059":1,"GO:0007254":1,"GO:0030509":1,"GO:0070059":1,"GO:1902426":1,"GO:0071347":1,"GO:0000278":2,"GO:0010976":1,"GO:0090089":1,"GO:0006293":1,"GO:0006295":1,"GO:1902104":2,"GO:0006296":1,"GO:0042769":1,"GO:0000715":1,"GO:0010265":1,"GO:0043162":1,"GO:0000717":1,"GO:0051759":2,"GO:0016567":1,"GO:0006294":1,"GO:0042787":3,"GO:0030174":1,"GO:0042752":1,"GO:1903378":1,"GO:0000083":1,"GO:0071406":1,"GO:0060386":1,"GO:0000209":1,"GO:0046685":1,"GO:0044346":1,"GO:0030097":1,"GO:0031915":1,"GO:0072576":1,"GO:0031286":1,"GO:0007295":1,"GO:0048575":1,"GO:0035024":1,"GO:0035518":1,"GO:1903467":1,"GO:0048825":1,"GO:0001831":1,"GO:0045773":1,"GO:0019102":1,"GO:0000082":1,"GO:0043149":1,"GO:0051232":1,"GO:0010100":1,"GO:0035019":1,"GO:0040016":1,"GO:0008283":1,"GO:0030154":1,"GO:0050775":1,"GO:0030853":1,"GO:1900087":1,"GO:2000001":1,"GO:2000819":1,"GO:0017145":1,"GO:0007399":1},"recipe_readded":[]}