{"hash":"2032480115999599601","title":"Ubiquitin-Proteasome Regulation and Stress Response","description":"This cluster centers on ubiquitin-mediated proteolysis (positive regulation of protein polyubiquitination; SCF-dependent proteasomal degradation), with connections to cell-cycle/DNA damage regulation and stress responses (cadmium/methylmercury exposure, oxidative stress, neuronal apoptosis). The inclusion of circadian rhythm regulation and synapse assembly suggests broader roles in neural signaling tied to proteostasis. Overall, the common theme is proteostasis via ubiquitin-proteasome pathways integrated with stress signaling.","confidence":"High","size":21,"edges":24,"triangles":1,"max_degree":6,"top_function":null,"members":[{"accession":"XP_025181561.2","go_terms":[]},{"accession":"XP_025184825.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065990144.1","go_terms":[]},{"accession":"XP_065995455.1","go_terms":[]},{"accession":"XP_065999486.1","go_terms":[]},{"accession":"XP_025173472.1","go_terms":[]},{"accession":"XP_025175830.1","go_terms":[]},{"accession":"XP_025183996.2","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066000112.1","go_terms":[]},{"accession":"XP_065993496.1","go_terms":[]},{"accession":"XP_065999637.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066005526.1","go_terms":[]},{"accession":"XP_065989041.1","go_terms":[]},{"accession":"XP_065989696.1","go_terms":["GO:0008285","GO:0070544","GO:0031146","GO:0046785","GO:0006516","GO:0007057","GO:0021678","GO:0021993","GO:0051436","GO:0001556","GO:0060386","GO:0031571","GO:0071406","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065991035.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065993767.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065997191.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065998787.1","go_terms":["GO:0008285","GO:0070544","GO:0031146","GO:0046785","GO:0006516","GO:0007057","GO:0021678","GO:0021993","GO:0051436","GO:0001556","GO:0060386","GO:0031571","GO:0071406","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065998869.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066004354.1","go_terms":[]},{"accession":"XP_066004357.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]}],"graph":[["XP_066000112.1","XP_065989696.1",0.609],["XP_066000112.1","XP_065997191.1",0.583],["XP_066000112.1","XP_066004354.1",0.519],["XP_066000112.1","XP_025173472.1",0.625],["XP_066005526.1","XP_065998869.1",0.614],["XP_065997191.1","XP_065990144.1",0.888],["XP_065997191.1","XP_065998787.1",0.528],["XP_065999486.1","XP_065999637.1",0.641],["XP_066004354.1","XP_025183996.2",0.741],["XP_066004354.1","XP_065998869.1",0.605],["XP_065998787.1","XP_025183996.2",0.574],["XP_065998787.1","XP_065989696.1",0.868],["XP_065998787.1","XP_065993767.1",0.844],["XP_065998787.1","XP_025173472.1",0.674],["XP_025175830.1","XP_065998869.1",0.875],["XP_065999637.1","XP_065990144.1",0.575],["XP_065991035.1","XP_025181561.2",0.546],["XP_025181561.2","XP_065990144.1",0.601],["XP_025181561.2","XP_066004357.1",0.556],["XP_025173472.1","XP_065990144.1",0.517],["XP_025173472.1","XP_065998869.1",0.668],["XP_065990144.1","XP_065998869.1",0.674],["XP_066004357.1","XP_065993496.1",0.721],["XP_065998869.1","XP_025184825.1",0.769]],"all_go_terms":{"GO:1902916":10,"GO:0030174":10,"GO:0042752":10,"GO:0031146":10,"GO:1903378":10,"GO:0071276":10,"GO:0031571":10,"GO:0000083":10,"GO:0071406":10,"GO:0060386":10,"GO:0000209":10,"GO:0046685":10,"GO:0042787":10,"GO:0008285":2,"GO:0021678":2,"GO:0046785":2,"GO:0021993":2,"GO:0051436":2,"GO:0006516":2,"GO:0001556":2,"GO:0070544":2,"GO:0007057":2},"recipe_readded":[]}