{"hash":"1771522102593427567","title":"Proteostasis and stress-response signaling","description":"This cluster centers on ubiquitin-proteasome turnover (positive regulation of polyubiquitination; SCF-dependent degradation) and regulators of circadian rhythm, alongside DNA-damage/checkpoint signaling, and cellular responses to heavy metal and oxidative stress in neurons. The combination suggests a set of proteins involved in protein turnover linked to stress responses and cell-cycle control, with additional links to synapse assembly. Overall, a proteostasis-and-stress-response theme best fits the shared functions.","confidence":"Medium","size":20,"edges":84,"triangles":112,"max_degree":13,"top_function":null,"members":[{"accession":"XP_065993471.1","go_terms":[]},{"accession":"XP_065994204.1","go_terms":[]},{"accession":"XP_065994213.1","go_terms":[]},{"accession":"XP_065998793.1","go_terms":[]},{"accession":"XP_066002879.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_025176886.1","go_terms":[]},{"accession":"XP_025185832.2","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065997319.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066001378.1","go_terms":[]},{"accession":"XP_025166894.1","go_terms":[]},{"accession":"XP_025178013.2","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_025174975.1","go_terms":[]},{"accession":"XP_025183487.2","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065999251.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066001021.1","go_terms":[]},{"accession":"XP_066001106.1","go_terms":[]},{"accession":"XP_066003752.1","go_terms":[]},{"accession":"XP_066003779.1","go_terms":[]},{"accession":"XP_025169098.1","go_terms":[]},{"accession":"XP_025170046.2","go_terms":[]}],"graph":[["XP_066001106.1","XP_025185832.2",0.506],["XP_066001106.1","XP_065993471.1",0.921],["XP_066001106.1","XP_065998793.1",0.868],["XP_066001106.1","XP_066003752.1",0.682],["XP_066001106.1","XP_066003779.1",0.834],["XP_066001106.1","XP_066002879.1",0.646],["XP_066001106.1","XP_066001021.1",0.675],["XP_066001106.1","XP_025169098.1",0.685],["XP_066001106.1","XP_025174975.1",0.501],["XP_066003752.1","XP_065993471.1",0.856],["XP_066003752.1","XP_065994204.1",0.506],["XP_066003752.1","XP_065997319.1",0.681],["XP_066003752.1","XP_065998793.1",0.927],["XP_066003752.1","XP_065999251.1",0.684],["XP_066003752.1","XP_066003779.1",0.682],["XP_066003752.1","XP_025170046.2",0.537],["XP_066003752.1","XP_025176886.1",0.836],["XP_025183487.2","XP_065993471.1",0.676],["XP_025183487.2","XP_065998793.1",0.936],["XP_025183487.2","XP_066001021.1",0.859],["XP_025183487.2","XP_025169098.1",0.964],["XP_025183487.2","XP_025174975.1",0.959],["XP_025170046.2","XP_025166894.1",0.577],["XP_025170046.2","XP_025174975.1",0.823],["XP_025170046.2","XP_025178013.2",0.777],["XP_025170046.2","XP_025185832.2",0.61],["XP_025170046.2","XP_065993471.1",0.643],["XP_025170046.2","XP_065994204.1",0.856],["XP_025170046.2","XP_065998793.1",0.744],["XP_025170046.2","XP_065999251.1",0.617],["XP_025170046.2","XP_066002879.1",0.598],["XP_065998793.1","XP_025185832.2",0.951],["XP_065998793.1","XP_065994213.1",0.845],["XP_065998793.1","XP_065997319.1",0.585],["XP_065998793.1","XP_066002879.1",0.935],["XP_065998793.1","XP_066001021.1",0.76],["XP_065998793.1","XP_025169098.1",0.943],["XP_025178013.2","XP_025185832.2",0.633],["XP_025178013.2","XP_065994204.1",0.596],["XP_025178013.2","XP_065997319.1",0.591],["XP_025178013.2","XP_065999251.1",0.729],["XP_025178013.2","XP_066002879.1",0.605],["XP_025178013.2","XP_066003779.1",0.585],["XP_025166894.1","XP_025174975.1",0.645],["XP_065994204.1","XP_025185832.2",0.626],["XP_065994204.1","XP_066003779.1",0.548],["XP_065994204.1","XP_066002879.1",0.645],["XP_065994204.1","XP_066001021.1",0.847],["XP_065994204.1","XP_025169098.1",0.683],["XP_065994204.1","XP_025174975.1",0.819],["XP_066001021.1","XP_065994213.1",0.582],["XP_066001021.1","XP_065997319.1",0.955],["XP_066001021.1","XP_065999251.1",0.96],["XP_066001021.1","XP_066003779.1",0.813],["XP_066001021.1","XP_066001378.1",0.596],["XP_066001021.1","XP_025169098.1",0.506],["XP_066001021.1","XP_025174975.1",0.63],["XP_065999251.1","XP_065993471.1",0.684],["XP_065999251.1","XP_065994213.1",0.628],["XP_065999251.1","XP_065997319.1",0.946],["XP_065999251.1","XP_066003779.1",0.795],["XP_065999251.1","XP_025169098.1",0.501],["XP_065999251.1","XP_025174975.1",0.509],["XP_025185832.2","XP_065993471.1",0.66],["XP_025185832.2","XP_065994213.1",0.547],["XP_025185832.2","XP_065997319.1",0.687],["XP_025185832.2","XP_025176886.1",0.554],["XP_066001378.1","XP_066002879.1",0.526],["XP_066003779.1","XP_065993471.1",0.847],["XP_066003779.1","XP_065994213.1",0.783],["XP_066003779.1","XP_065997319.1",0.695],["XP_065993471.1","XP_065994213.1",0.567],["XP_065993471.1","XP_065997319.1",0.77],["XP_065993471.1","XP_066002879.1",0.851],["XP_065993471.1","XP_025169098.1",0.856],["XP_065993471.1","XP_025174975.1",0.735],["XP_065993471.1","XP_025176886.1",0.93],["XP_066002879.1","XP_025174975.1",0.846],["XP_065994213.1","XP_065997319.1",0.59],["XP_065994213.1","XP_025169098.1",0.859],["XP_065994213.1","XP_025174975.1",0.578],["XP_025176886.1","XP_025169098.1",0.855],["XP_065997319.1","XP_025174975.1",0.755],["XP_025174975.1","XP_025169098.1",0.846]],"all_go_terms":{"GO:1902916":6,"GO:0030174":6,"GO:0042752":6,"GO:0031146":6,"GO:1903378":6,"GO:0071276":6,"GO:0031571":6,"GO:0000083":6,"GO:0071406":6,"GO:0060386":6,"GO:0000209":6,"GO:0046685":6,"GO:0042787":6},"recipe_readded":[]}