{"hash":"1425067151916659183","title":"Ubiquitin-Proteasome Regulation and Stress Response","description":"This cluster is enriched for ubiquitin-proteasome\u2013related processes (positive regulation of polyubiquitination; SCF-dependent proteasomal ubiquitin-dependent degradation), indicating a focus on protein turnover. It also includes functions related to cell cycle regulation (circadian rhythm regulation, DNA damage checkpoint signaling) and various stress responses (heavy metals and oxidative stress in neurons, synapse assembly). The common theme appears to be regulation of proteostasis intertwined with cell cycle and stress response pathways, possibly with neuronal context.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"XP_025178165.1","go_terms":[]},{"accession":"XP_025184462.1","go_terms":[]},{"accession":"XP_025178167.1","go_terms":[]},{"accession":"XP_065992823.1","go_terms":[]},{"accession":"XP_066006148.1","go_terms":[]},{"accession":"XP_066004036.1","go_terms":[]},{"accession":"XP_025167136.2","go_terms":[]},{"accession":"XP_025173467.1","go_terms":[]},{"accession":"XP_025175776.1","go_terms":[]},{"accession":"XP_025178151.1","go_terms":[]},{"accession":"XP_025186538.1","go_terms":[]},{"accession":"XP_025180222.2","go_terms":[]},{"accession":"XP_065991486.1","go_terms":[]},{"accession":"XP_065989914.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_065999394.1","go_terms":[]},{"accession":"XP_065994503.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_066001169.1","go_terms":[]},{"accession":"XP_025166647.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_025167526.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"XP_025170926.1","go_terms":[]},{"accession":"XP_025175238.2","go_terms":[]}],"graph":[],"all_go_terms":{"GO:1902916":4,"GO:0030174":4,"GO:0042752":4,"GO:0031146":4,"GO:1903378":4,"GO:0071276":4,"GO:0031571":4,"GO:0000083":4,"GO:0071406":4,"GO:0060386":4,"GO:0000209":4,"GO:0046685":4,"GO:0042787":4},"recipe_readded":["XP_066004475.1","XP_025181325.2","XP_065988912.1","XP_065992798.1","XP_025180904.2","XP_025180014.2","XP_025182497.2","XP_025169536.1","XP_025165827.1","XP_065997907.1","XP_066000979.1","XP_025186163.1","XP_025181183.1","XP_025174145.2","XP_025186103.2","XP_025180427.1","XP_066005290.1","XP_025188383.1","XP_025171856.1","XP_025178258.2"]}