{"hash":"2021191403459886993","title":"Folate-Mediated One-Carbon Metabolism","description":"This cluster is enriched for GO terms centered on folate metabolism and one-carbon transfer: tetrahydrofolate biosynthesis, one-carbon metabolic process, dTMP and glycine biosynthesis, and methotrexate response; these indicate involvement in the folate cycle and nucleotide biosynthesis pathways (thymidylate and amino acid biosynthesis). A few terms about redox regulation and axon regeneration appear, but they are likely secondary to the core folate/one-carbon metabolism theme.","confidence":"High","size":9,"edges":32,"triangles":62,"max_degree":8,"top_function":null,"members":[{"accession":"XP_051454512.1","go_terms":["GO:0033539","GO:0009437"]},{"accession":"XP_051455868.1","go_terms":["GO:0006909","GO:0030240","GO:0010628","GO:0021762","GO:0034314","GO:0051654","GO:0002121","GO:0042766","GO:0043503","GO:0071963","GO:0009825","GO:0006348","GO:0000147","GO:0000001","GO:0043486","GO:0000281","GO:0016344","GO:0030476","GO:1904623","GO:0048741","GO:0032508","GO:0051017","GO:0045214","GO:0051666","GO:0030041","GO:0001895","GO:0030100","GO:0090131","GO:0051592","GO:0000011","GO:0000916","GO:0001300","GO:0043982","GO:0043983","GO:0043981","GO:0070527","GO:1903475","GO:0098974"]},{"accession":"XP_051459650.1","go_terms":[]},{"accession":"XP_051460739.1","go_terms":["GO:0006730","GO:0000083","GO:0051000","GO:0046655","GO:0046654","GO:0006545","GO:0032259","GO:0006729","GO:0031103","GO:0046105","GO:0055114","GO:2000121","GO:0006231","GO:0031427","GO:0046452","GO:0046677"]},{"accession":"XP_051453219.1","go_terms":["GO:0019740","GO:0001302","GO:1904524","GO:0006602","GO:0006769","GO:0006212","GO:0019358","GO:0002047"]},{"accession":"XP_051453621.1","go_terms":["GO:0006730","GO:0000083","GO:0051000","GO:0046655","GO:0046654","GO:0006545","GO:0032259","GO:0006729","GO:0031103","GO:0046105","GO:0055114","GO:2000121","GO:0006231","GO:0031427","GO:0046452","GO:0046677"]},{"accession":"XP_051456487.1","go_terms":[]},{"accession":"XP_051461097.1","go_terms":["GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"XP_051463410.1","go_terms":["GO:0030836","GO:0016311","GO:0032361","GO:0009244","GO:0071318","GO:0097171","GO:0031247","GO:0009103","GO:0033574","GO:0006564","GO:0097755","GO:0006874","GO:0070574","GO:0071577","GO:0006825","GO:0046839","GO:0019373","GO:0046272","GO:0046196","GO:0006470","GO:0046050","GO:0006114"]}],"graph":[["XP_051459650.1","XP_051453219.1",0.856],["XP_051459650.1","XP_051453621.1",0.972],["XP_051459650.1","XP_051454512.1",0.984],["XP_051459650.1","XP_051455868.1",0.936],["XP_051459650.1","XP_051456487.1",0.799],["XP_051459650.1","XP_051460739.1",0.818],["XP_051459650.1","XP_051461097.1",0.978],["XP_051459650.1","XP_051463410.1",0.694],["XP_051453621.1","XP_051453219.1",0.698],["XP_051453621.1","XP_051456487.1",0.647],["XP_051453621.1","XP_051455868.1",0.973],["XP_051453621.1","XP_051454512.1",0.885],["XP_051453621.1","XP_051460739.1",0.955],["XP_051453621.1","XP_051461097.1",0.912],["XP_051453621.1","XP_051463410.1",0.854],["XP_051456487.1","XP_051453219.1",0.859],["XP_051456487.1","XP_051454512.1",0.962],["XP_051456487.1","XP_051455868.1",0.923],["XP_051456487.1","XP_051460739.1",0.632],["XP_051456487.1","XP_051461097.1",0.988],["XP_051456487.1","XP_051463410.1",0.69],["XP_051453219.1","XP_051455868.1",0.502],["XP_051455868.1","XP_051454512.1",0.973],["XP_051455868.1","XP_051463410.1",0.694],["XP_051455868.1","XP_051461097.1",0.83],["XP_051455868.1","XP_051460739.1",0.948],["XP_051461097.1","XP_051454512.1",0.944],["XP_051461097.1","XP_051460739.1",0.567],["XP_051461097.1","XP_051463410.1",0.831],["XP_051463410.1","XP_051454512.1",0.962],["XP_051463410.1","XP_051460739.1",0.963],["XP_051454512.1","XP_051460739.1",0.984]],"all_go_terms":{"GO:0033539":1,"GO:0009437":1,"GO:0032508":1,"GO:0090131":1,"GO:0009825":1,"GO:0043503":1,"GO:0051592":1,"GO:0030476":1,"GO:0051017":1,"GO:0021762":1,"GO:0070527":1,"GO:0042766":1,"GO:0006348":1,"GO:0010628":1,"GO:0030100":1,"GO:0030041":1,"GO:0043983":1,"GO:0000916":1,"GO:0030240":1,"GO:0043486":1,"GO:0001300":1,"GO:0006909":1,"GO:0000001":1,"GO:0043982":1,"GO:0048741":1,"GO:0045214":1,"GO:0002121":1,"GO:0043981":1,"GO:0071963":1,"GO:0000281":1,"GO:0016344":1,"GO:0000011":1,"GO:0000147":1,"GO:1904623":1,"GO:1903475":1,"GO:0001895":1,"GO:0098974":1,"GO:0034314":1,"GO:0051654":1,"GO:0051666":1,"GO:0046654":2,"GO:0031427":2,"GO:0032259":2,"GO:0006545":2,"GO:2000121":2,"GO:0006730":2,"GO:0051000":2,"GO:0031103":2,"GO:0055114":2,"GO:0006231":2,"GO:0046105":2,"GO:0006729":2,"GO:0000083":2,"GO:0046452":2,"GO:0046677":2,"GO:0046655":2,"GO:0006769":1,"GO:0002047":1,"GO:0019358":1,"GO:0006212":1,"GO:0006602":1,"GO:1904524":1,"GO:0019740":1,"GO:0001302":1,"GO:0031204":1,"GO:1903751":1,"GO:0000742":1,"GO:0006880":1,"GO:0090084":1,"GO:0016226":1,"GO:1902037":1,"GO:1900035":1,"GO:0070880":1,"GO:0034620":1,"GO:0006260":1,"GO:0070389":1,"GO:1903382":1,"GO:0006616":1,"GO:0006825":1,"GO:0046272":1,"GO:0032361":1,"GO:0006114":1,"GO:0097755":1,"GO:0030836":1,"GO:0046839":1,"GO:0006564":1,"GO:0097171":1,"GO:0019373":1,"GO:0016311":1,"GO:0046050":1,"GO:0006470":1,"GO:0071318":1,"GO:0046196":1,"GO:0009103":1,"GO:0071577":1,"GO:0006874":1,"GO:0031247":1,"GO:0033574":1,"GO:0070574":1,"GO:0009244":1},"recipe_readded":[]}