{"hash":"1860447734483097437","title":"Membrane trafficking and Notch-related proteolysis","description":"The Top Terms center on intracellular transport between ER, Golgi, and endosomes, i.e., protein transport and vesicle trafficking, plus proteolysis of membrane proteins (ectodomain and ICD). The notable inclusion of Notch signaling and pharynx development hints at developmental membrane signaling tied to proteolytic processing. A concise label that ties trafficking with membrane proteolysis, especially in the context of Notch, fits best.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"members":[{"accession":"XP_051452832.1","go_terms":["GO:0006888","GO:0042147","GO:0015031"]},{"accession":"XP_051451817.1","go_terms":["GO:0015986","GO:0035786","GO:0042407"]},{"accession":"XP_051450125.1","go_terms":["GO:0007219","GO:0034205","GO:0006509","GO:0007220","GO:0031293","GO:0060465"]},{"accession":"XP_051455796.1","go_terms":[]},{"accession":"XP_051461449.1","go_terms":[]},{"accession":"XP_051461507.1","go_terms":[]},{"accession":"XP_051456608.1","go_terms":[]},{"accession":"XP_051460907.1","go_terms":[]}],"graph":[["XP_051455796.1","XP_051450125.1",0.816],["XP_051455796.1","XP_051451817.1",0.633],["XP_051455796.1","XP_051452832.1",0.874],["XP_051456608.1","XP_051452832.1",0.509],["XP_051461449.1","XP_051452832.1",0.867],["XP_051461507.1","XP_051452832.1",0.917],["XP_051452832.1","XP_051460907.1",0.545]],"all_go_terms":{"GO:0006888":1,"GO:0015031":1,"GO:0042147":1,"GO:0035786":1,"GO:0015986":1,"GO:0042407":1,"GO:0007219":1,"GO:0006509":1,"GO:0060465":1,"GO:0031293":1,"GO:0007220":1,"GO:0034205":1},"recipe_readded":[]}