{"hash":"19132141949345767","title":"Ubiquitin-Proteasome\u2013MHC I Antigen Presentation Pathway","description":"The terms cluster around ubiquitin-dependent protein turnover (deubiquitination, SCF-proteasome), antigen processing and presentation via MHC I, and immune signaling (T cell receptor and Fc-epsilon receptor pathways), all pointing to antigen presentation and adaptive immune activation controlled by ubiquitin-proteasome dynamics. Viral process terms support involvement in antigen processing of infected cells, while metal- and salt-stress responses are ancillary cellular stress signals. Overall, the theme is immune antigen presentation linked to ubiquitin-proteasome regulation.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"members":[{"accession":"XP_046450308.1","go_terms":["GO:0006284","GO:0097510"]},{"accession":"XP_046459988.1","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]},{"accession":"XP_046439274.1","go_terms":["GO:0032436","GO:0070911","GO:0034126","GO:0090204","GO:0010286","GO:1901896","GO:0071276","GO:0043392","GO:0060334","GO:0051572","GO:0016925","GO:0043433","GO:0035186","GO:0086004","GO:0030578","GO:1902260","GO:0045944","GO:0045759","GO:0060340","GO:1901097","GO:0006468","GO:1901340","GO:0035458","GO:0000226","GO:0030010","GO:0001828","GO:0001827","GO:1903094","GO:1904153","GO:2000157","GO:0010994","GO:0035973","GO:1904378","GO:0030474","GO:0032815","GO:1903071","GO:0006289","GO:0034140","GO:0035523","GO:0030433","GO:0035278","GO:0035329","GO:0044313","GO:1900186","GO:0070059","GO:0016567","GO:1904021","GO:0006517","GO:0000423","GO:0033132","GO:1902236","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:1901799","GO:1902283","GO:0016579","GO:0017085","GO:0051865","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1904049","GO:0006412"]},{"accession":"XP_046437502.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_046439207.1","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]},{"accession":"XP_046439440.1","go_terms":["GO:0034727","GO:0000422","GO:0061723","GO:0006501","GO:0035096","GO:0044805","GO:0032258","GO:0000045","GO:0000226","GO:0034198","GO:0010940","GO:0010040","GO:0034629","GO:0040024","GO:0008625","GO:0006888","GO:0097352","GO:0071211","GO:0070301","GO:0010288","GO:0061709","GO:0006915","GO:0043278","GO:0071280","GO:0070257"]},{"accession":"XP_046440824.1","go_terms":["GO:0034727","GO:0000422","GO:0061723","GO:0006501","GO:0035096","GO:0044805","GO:0032258","GO:0000045","GO:0000226","GO:0034198","GO:0010940","GO:0010040","GO:0034629","GO:0040024","GO:0008625","GO:0006888","GO:0097352","GO:0071211","GO:0070301","GO:0010288","GO:0061709","GO:0006915","GO:0043278","GO:0071280","GO:0070257"]},{"accession":"XP_046445890.1","go_terms":["GO:0034727","GO:0000422","GO:0061723","GO:0006501","GO:0035096","GO:0044805","GO:0032258","GO:0000045","GO:0000226","GO:0034198","GO:0010940","GO:0010040","GO:0034629","GO:0040024","GO:0008625","GO:0006888","GO:0097352","GO:0071211","GO:0070301","GO:0010288","GO:0061709","GO:0006915","GO:0043278","GO:0071280","GO:0070257"]},{"accession":"XP_046446714.1","go_terms":["GO:0000289","GO:0010606","GO:0006397","GO:0034729","GO:0000245","GO:0048149","GO:1990108","GO:0071108","GO:0021551","GO:0051568","GO:0001662","GO:0035871","GO:0008583","GO:1904667","GO:0010995","GO:0070537","GO:0010992","GO:1904378","GO:0060013","GO:1903070","GO:0035520","GO:0035523","GO:0008343","GO:0044313","GO:1900425","GO:1901026","GO:0035192","GO:0006355","GO:0006511","GO:0006351","GO:0035616"]},{"accession":"XP_046453189.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_046454507.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_046456509.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_046458518.1","go_terms":["GO:0045190","GO:0009688","GO:0044810","GO:0090282","GO:0090419","GO:0009190","GO:0033624","GO:0021693","GO:1903468","GO:0034244","GO:1990705","GO:0032487","GO:0051237","GO:0070535","GO:0035196","GO:0072383","GO:0007249","GO:0090055","GO:0021685","GO:1905150"]},{"accession":"XP_046459977.1","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]},{"accession":"XP_046461905.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_046463974.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_046445487.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_046462813.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_046459976.1","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]}],"graph":[["XP_046440824.1","XP_046437502.1",0.914],["XP_046440824.1","XP_046439207.1",0.964],["XP_046440824.1","XP_046439274.1",0.924],["XP_046440824.1","XP_046439440.1",0.731],["XP_046440824.1","XP_046445487.1",0.978],["XP_046440824.1","XP_046445890.1",0.859],["XP_046440824.1","XP_046446714.1",0.775],["XP_046440824.1","XP_046450308.1",0.696],["XP_046440824.1","XP_046453189.1",0.923],["XP_046440824.1","XP_046454507.1",0.927],["XP_046440824.1","XP_046456509.1",0.86],["XP_046440824.1","XP_046458518.1",0.96],["XP_046440824.1","XP_046459976.1",0.939],["XP_046440824.1","XP_046459977.1",0.944],["XP_046440824.1","XP_046459988.1",0.982],["XP_046440824.1","XP_046461905.1",0.968],["XP_046440824.1","XP_046462813.1",0.869],["XP_046440824.1","XP_046463974.1",0.936],["XP_046437502.1","XP_046439207.1",0.951],["XP_046437502.1","XP_046439274.1",0.881],["XP_046437502.1","XP_046439440.1",0.952],["XP_046437502.1","XP_046445487.1",0.969],["XP_046437502.1","XP_046445890.1",0.816],["XP_046437502.1","XP_046446714.1",0.876],["XP_046437502.1","XP_046450308.1",0.847],["XP_046437502.1","XP_046453189.1",0.957],["XP_046437502.1","XP_046454507.1",0.886],["XP_046437502.1","XP_046456509.1",0.632],["XP_046437502.1","XP_046458518.1",0.962],["XP_046437502.1","XP_046459976.1",0.899],["XP_046437502.1","XP_046459977.1",0.959],["XP_046437502.1","XP_046459988.1",0.957],["XP_046437502.1","XP_046461905.1",0.952],["XP_046437502.1","XP_046462813.1",0.826],["XP_046437502.1","XP_046463974.1",0.946],["XP_046445890.1","XP_046439207.1",0.976],["XP_046445890.1","XP_046439274.1",0.805],["XP_046445890.1","XP_046439440.1",0.981],["XP_046445890.1","XP_046445487.1",0.89],["XP_046445890.1","XP_046446714.1",0.937],["XP_046445890.1","XP_046450308.1",0.873],["XP_046445890.1","XP_046453189.1",0.988],["XP_046445890.1","XP_046454507.1",0.97],["XP_046445890.1","XP_046456509.1",0.867],["XP_046445890.1","XP_046458518.1",0.971],["XP_046445890.1","XP_046459976.1",0.969],["XP_046445890.1","XP_046459977.1",0.975],["XP_046445890.1","XP_046459988.1",0.988],["XP_046445890.1","XP_046461905.1",0.987],["XP_046445890.1","XP_046462813.1",0.958],["XP_046445890.1","XP_046463974.1",0.916],["XP_046459976.1","XP_046439207.1",0.952],["XP_046459976.1","XP_046439274.1",0.84],["XP_046459976.1","XP_046439440.1",0.961],["XP_046459976.1","XP_046445487.1",0.976],["XP_046459976.1","XP_046446714.1",0.926],["XP_046459976.1","XP_046450308.1",0.984],["XP_046459976.1","XP_046453189.1",0.971],["XP_046459976.1","XP_046454507.1",0.974],["XP_046459976.1","XP_046456509.1",0.951],["XP_046459976.1","XP_046458518.1",0.868],["XP_046459976.1","XP_046459977.1",0.945],["XP_046459976.1","XP_046459988.1",0.984],["XP_046459976.1","XP_046461905.1",0.936],["XP_046459976.1","XP_046462813.1",0.944],["XP_046459976.1","XP_046463974.1",0.896],["XP_046454507.1","XP_046439207.1",0.969],["XP_046454507.1","XP_046439274.1",0.962],["XP_046454507.1","XP_046439440.1",0.974],["XP_046454507.1","XP_046445487.1",0.982],["XP_046454507.1","XP_046446714.1",0.892],["XP_046454507.1","XP_046450308.1",0.989],["XP_046454507.1","XP_046453189.1",0.977],["XP_046454507.1","XP_046463974.1",0.915],["XP_046454507.1","XP_046462813.1",0.959],["XP_046454507.1","XP_046461905.1",0.939],["XP_046454507.1","XP_046459977.1",0.93],["XP_046454507.1","XP_046459988.1",0.957],["XP_046454507.1","XP_046458518.1",0.939],["XP_046454507.1","XP_046456509.1",0.963],["XP_046458518.1","XP_046439207.1",0.97],["XP_046458518.1","XP_046439274.1",0.981],["XP_046458518.1","XP_046439440.1",0.97],["XP_046458518.1","XP_046445487.1",0.988],["XP_046458518.1","XP_046446714.1",0.981],["XP_046458518.1","XP_046450308.1",0.988],["XP_046458518.1","XP_046453189.1",0.962],["XP_046458518.1","XP_046456509.1",0.967],["XP_046458518.1","XP_046463974.1",0.921],["XP_046458518.1","XP_046462813.1",0.941],["XP_046458518.1","XP_046461905.1",0.889],["XP_046458518.1","XP_046459977.1",0.955],["XP_046458518.1","XP_046459988.1",0.983],["XP_046439274.1","XP_046439207.1",0.978],["XP_046439274.1","XP_046439440.1",0.978],["XP_046439274.1","XP_046445487.1",0.94],["XP_046439274.1","XP_046446714.1",0.782],["XP_046439274.1","XP_046450308.1",0.964],["XP_046439274.1","XP_046453189.1",0.985],["XP_046439274.1","XP_046456509.1",0.825],["XP_046439274.1","XP_046459977.1",0.983],["XP_046439274.1","XP_046459988.1",0.961],["XP_046439274.1","XP_046461905.1",0.97],["XP_046439274.1","XP_046462813.1",0.822],["XP_046439274.1","XP_046463974.1",0.926],["XP_046461905.1","XP_046439207.1",0.965],["XP_046461905.1","XP_046439440.1",0.971],["XP_046461905.1","XP_046445487.1",0.988],["XP_046461905.1","XP_046446714.1",0.901],["XP_046461905.1","XP_046450308.1",0.96],["XP_046461905.1","XP_046453189.1",0.958],["XP_046461905.1","XP_046456509.1",0.849],["XP_046461905.1","XP_046459977.1",0.959],["XP_046461905.1","XP_046459988.1",0.961],["XP_046461905.1","XP_046462813.1",0.895],["XP_046461905.1","XP_046463974.1",0.958],["XP_046446714.1","XP_046439207.1",0.962],["XP_046446714.1","XP_046439440.1",0.961],["XP_046446714.1","XP_046445487.1",0.895],["XP_046446714.1","XP_046450308.1",0.871],["XP_046446714.1","XP_046453189.1",0.899],["XP_046446714.1","XP_046456509.1",0.78],["XP_046446714.1","XP_046459977.1",0.957],["XP_046446714.1","XP_046459988.1",0.961],["XP_046446714.1","XP_046462813.1",0.809],["XP_046446714.1","XP_046463974.1",0.824],["XP_046462813.1","XP_046439207.1",0.963],["XP_046462813.1","XP_046439440.1",0.969],["XP_046462813.1","XP_046445487.1",0.973],["XP_046462813.1","XP_046450308.1",0.963],["XP_046462813.1","XP_046453189.1",0.976],["XP_046462813.1","XP_046456509.1",0.772],["XP_046462813.1","XP_046459977.1",0.97],["XP_046462813.1","XP_046459988.1",0.922],["XP_046462813.1","XP_046463974.1",0.944],["XP_046459988.1","XP_046439207.1",0.982],["XP_046459988.1","XP_046439440.1",0.959],["XP_046459988.1","XP_046445487.1",0.988],["XP_046459988.1","XP_046450308.1",0.985],["XP_046459988.1","XP_046453189.1",0.978],["XP_046459988.1","XP_046456509.1",0.97],["XP_046459988.1","XP_046459977.1",0.987],["XP_046459988.1","XP_046463974.1",0.857],["XP_046439207.1","XP_046439440.1",0.974],["XP_046439207.1","XP_046445487.1",0.988],["XP_046439207.1","XP_046450308.1",0.985],["XP_046439207.1","XP_046453189.1",0.96],["XP_046439207.1","XP_046456509.1",0.98],["XP_046439207.1","XP_046459977.1",0.954],["XP_046439207.1","XP_046463974.1",0.935],["XP_046459977.1","XP_046439440.1",0.96],["XP_046459977.1","XP_046445487.1",0.988],["XP_046459977.1","XP_046450308.1",0.984],["XP_046459977.1","XP_046453189.1",0.967],["XP_046459977.1","XP_046456509.1",0.982],["XP_046459977.1","XP_046463974.1",0.928],["XP_046439440.1","XP_046445487.1",0.985],["XP_046439440.1","XP_046450308.1",0.933],["XP_046439440.1","XP_046453189.1",0.958],["XP_046439440.1","XP_046456509.1",0.934],["XP_046439440.1","XP_046463974.1",0.935],["XP_046463974.1","XP_046445487.1",0.943],["XP_046463974.1","XP_046450308.1",0.905],["XP_046463974.1","XP_046453189.1",0.858],["XP_046463974.1","XP_046456509.1",0.809],["XP_046456509.1","XP_046445487.1",0.911],["XP_046456509.1","XP_046450308.1",0.897],["XP_046456509.1","XP_046453189.1",0.932],["XP_046453189.1","XP_046445487.1",0.975],["XP_046453189.1","XP_046450308.1",0.985],["XP_046445487.1","XP_046450308.1",0.979]],"all_go_terms":{"GO:0097510":1,"GO:0006284":1,"GO:1905907":4,"GO:0099641":4,"GO:0070309":4,"GO:0031109":4,"GO:1900034":4,"GO:0007568":4,"GO:0032387":4,"GO:0050821":4,"GO:0042542":4,"GO:0032463":4,"GO:0009408":4,"GO:0030308":4,"GO:0070141":4,"GO:0032355":4,"GO:2000378":4,"GO:0009644":4,"GO:0071480":4,"GO:0006936":4,"GO:0051403":4,"GO:0006412":1,"GO:0034140":1,"GO:1900186":1,"GO:0051865":1,"GO:0033132":1,"GO:0010636":1,"GO:0086004":1,"GO:0045759":1,"GO:1903094":1,"GO:0035973":1,"GO:1902236":1,"GO:0006357":1,"GO:0030010":1,"GO:0002109":1,"GO:0097237":1,"GO:0030433":1,"GO:0014070":1,"GO:0010637":1,"GO:0001827":1,"GO:0016925":1,"GO:0010994":1,"GO:0035186":1,"GO:0044313":2,"GO:0006468":1,"GO:1901340":1,"GO:0035523":2,"GO:0034126":1,"GO:0000226":4,"GO:1903071":1,"GO:1901799":1,"GO:0071816":1,"GO:0060340":1,"GO:0006517":1,"GO:0010286":1,"GO:0090204":1,"GO:0070911":1,"GO:1904153":1,"GO:0071276":1,"GO:0006289":1,"GO:0051572":1,"GO:0030474":1,"GO:1902260":1,"GO:0016567":1,"GO:0000028":1,"GO:0032436":1,"GO:0043433":1,"GO:0016579":9,"GO:2000157":1,"GO:0060334":1,"GO:1901097":1,"GO:0035329":1,"GO:0021888":1,"GO:1901896":1,"GO:0001828":1,"GO:0045648":1,"GO:0000753":1,"GO:1905366":1,"GO:0070059":1,"GO:0045944":1,"GO:1904021":1,"GO:1903265":1,"GO:0000423":1,"GO:0035458":1,"GO:0032815":1,"GO:1904378":2,"GO:0070842":1,"GO:0035278":1,"GO:0010216":1,"GO:0017085":1,"GO:1902283":1,"GO:0030578":1,"GO:0043392":1,"GO:1904049":1,"GO:0010043":8,"GO:0002479":8,"GO:0010972":8,"GO:0050852":8,"GO:0031146":8,"GO:0009651":8,"GO:0046686":8,"GO:0016032":8,"GO:0038095":8,"GO:0006521":8,"GO:0090263":8,"GO:0080129":8,"GO:0061418":8,"GO:0002862":8,"GO:0010363":8,"GO:0051436":8,"GO:0043488":8,"GO:0090090":8,"GO:0060071":8,"GO:0010499":8,"GO:0010950":8,"GO:0051437":8,"GO:0031145":8,"GO:0002223":8,"GO:0033209":8,"GO:0038061":8,"GO:0006888":3,"GO:0008625":3,"GO:0070301":3,"GO:0061723":3,"GO:0034629":3,"GO:0006915":3,"GO:0071211":3,"GO:0071280":3,"GO:0035096":3,"GO:0000422":3,"GO:0034198":3,"GO:0070257":3,"GO:0097352":3,"GO:0044805":3,"GO:0010040":3,"GO:0034727":3,"GO:0006501":3,"GO:0000045":3,"GO:0032258":3,"GO:0010940":3,"GO:0010288":3,"GO:0043278":3,"GO:0061709":3,"GO:0040024":3,"GO:0060013":1,"GO:1900425":1,"GO:0006351":1,"GO:0071108":1,"GO:0034729":1,"GO:0010995":1,"GO:0035871":1,"GO:0006355":1,"GO:0000245":1,"GO:1904667":1,"GO:0070537":1,"GO:0001662":1,"GO:0010606":1,"GO:0048149":1,"GO:1901026":1,"GO:0021551":1,"GO:0035520":1,"GO:0035616":1,"GO:0051568":1,"GO:0010992":1,"GO:0006397":1,"GO:0000289":1,"GO:0035192":1,"GO:0006511":1,"GO:0008343":1,"GO:1903070":1,"GO:1990108":1,"GO:0008583":1,"GO:0070535":1,"GO:0021693":1,"GO:0009688":1,"GO:0021685":1,"GO:1903468":1,"GO:0090419":1,"GO:0032487":1,"GO:0034244":1,"GO:0007249":1,"GO:0009190":1,"GO:0035196":1,"GO:0090055":1,"GO:0051237":1,"GO:1990705":1,"GO:0044810":1,"GO:1905150":1,"GO:0090282":1,"GO:0033624":1,"GO:0072383":1,"GO:0045190":1},"recipe_readded":[]}