{"hash":"1652396167190662742","title":"Neuronal SNARE-mediated vesicle trafficking and exocytosis","description":"This cluster centers on Golgi-to-transport vesicle pathways and SNARE-driven fusion, combined with neuronal exocytosis and receptor trafficking at the synapse. The prominent terms\u2014intra-Golgi and ER-to-Golgi transport, Golgi ribbon formation, SNARE complex assembly, vesicle fusion with Golgi, exocytic insertion of neurotransmitter receptors, and neurotransmitter secretion/LTP\u2014point to a cohesive role in delivering vesicles to the synaptic membrane and mediating neurotransmitter release and receptor targeting.","confidence":"High","size":15,"edges":55,"triangles":55,"max_degree":11,"top_function":"intracellular protein transport","members":[{"accession":"XP_046464196.1","go_terms":["GO:0032869","GO:0043308","GO:0006888","GO:0090161","GO:1903595","GO:0043001","GO:0043320","GO:0098967","GO:0016240","GO:0090316","GO:0042144","GO:0042147","GO:0006891","GO:0001921","GO:0060291","GO:0016079","GO:0043312","GO:0048280","GO:1902259","GO:0043134","GO:0070254","GO:0035493","GO:1900483"]},{"accession":"XP_046463736.1","go_terms":["GO:0051024","GO:0061669","GO:0010807","GO:1903358","GO:1903575","GO:0007340","GO:1904050","GO:0010701","GO:2000010","GO:0090161","GO:0097352","GO:1903422","GO:0032258","GO:0098967","GO:1902685","GO:2000463","GO:1903078","GO:0016081","GO:0010811","GO:0006888","GO:0045022","GO:0034498","GO:0001916","GO:0006891","GO:0006896","GO:0060291","GO:0051469","GO:0043311","GO:0031629","GO:0048280","GO:0097111","GO:0033194","GO:0006675","GO:0090166","GO:0035493","GO:0035774","GO:0030154","GO:0031321","GO:0050921","GO:0006886","GO:0045956","GO:0048791","GO:0098917","GO:0060471","GO:0016192"]},{"accession":"XP_046464338.1","go_terms":["GO:0051024","GO:0061669","GO:0010807","GO:1903358","GO:1903575","GO:0007340","GO:1904050","GO:0010701","GO:2000010","GO:0090161","GO:0097352","GO:1903422","GO:0032258","GO:0098967","GO:1902685","GO:2000463","GO:1903078","GO:0016081","GO:0010811","GO:0006888","GO:0045022","GO:0034498","GO:0001916","GO:0006891","GO:0006896","GO:0060291","GO:0051469","GO:0043311","GO:0031629","GO:0048280","GO:0097111","GO:0033194","GO:0006675","GO:0090166","GO:0035493","GO:0035774","GO:0030154","GO:0031321","GO:0050921","GO:0006886","GO:0045956","GO:0048791","GO:0098917","GO:0060471"]},{"accession":"XP_046440173.1","go_terms":["GO:2000049","GO:0008105","GO:0051666","GO:0000282"]},{"accession":"XP_046446223.1","go_terms":["GO:0045892","GO:0019363"]},{"accession":"XP_046456618.1","go_terms":["GO:0006360","GO:0070816","GO:0006289"]},{"accession":"XP_046456620.1","go_terms":["GO:0006360","GO:0070816","GO:0006289"]},{"accession":"XP_046442708.1","go_terms":["GO:0051024","GO:0061669","GO:0010807","GO:1903358","GO:1903575","GO:0007340","GO:1904050","GO:0010701","GO:2000010","GO:0090161","GO:0097352","GO:1903422","GO:0032258","GO:0098967","GO:1902685","GO:2000463","GO:1903078","GO:0016081","GO:0010811","GO:0006888","GO:0045022","GO:0034498","GO:0001916","GO:0006891","GO:0006896","GO:0060291","GO:0051469","GO:0043311","GO:0031629","GO:0048280","GO:0097111","GO:0033194","GO:0006675","GO:0090166","GO:0035493"]},{"accession":"XP_046445288.1","go_terms":["GO:0051024","GO:0061669","GO:0010807","GO:1903358","GO:1903575","GO:0007340","GO:1904050","GO:0010701","GO:2000010","GO:0090161","GO:0097352","GO:1903422","GO:0032258","GO:0098967","GO:1902685","GO:2000463","GO:1903078","GO:0016081","GO:0010811","GO:0006888","GO:0045022","GO:0034498","GO:0001916","GO:0006891","GO:0006896","GO:0060291","GO:0051469","GO:0043311","GO:0031629","GO:0048280","GO:0097111","GO:0033194","GO:0006675","GO:0090166","GO:0035493","GO:0045732","GO:0006886","GO:0048278"]},{"accession":"XP_046453262.1","go_terms":["GO:0032869","GO:0043308","GO:0006888","GO:0090161","GO:1903595","GO:0043001","GO:0043320","GO:0098967","GO:0016240","GO:0090316","GO:0042144","GO:0042147","GO:0006891","GO:0001921","GO:0060291","GO:0016079","GO:0043312","GO:0048280","GO:1902259","GO:0043134","GO:0070254","GO:0035493","GO:1900483"]},{"accession":"XP_046455320.1","go_terms":[]},{"accession":"XP_046437908.1","go_terms":["GO:0050882","GO:0006891","GO:0006888","GO:0006896","GO:0016236","GO:0090161","GO:0006623","GO:0048280","GO:0042144","GO:0042147","GO:1903076"]},{"accession":"XP_046456858.1","go_terms":["GO:0051024","GO:0061669","GO:0010807","GO:1903358","GO:1903575","GO:0007340","GO:1904050","GO:0010701","GO:2000010","GO:0090161","GO:0097352","GO:1903422","GO:0032258","GO:0098967","GO:1902685","GO:2000463","GO:1903078","GO:0016081","GO:0010811","GO:0006888","GO:0045022","GO:0034498","GO:0001916","GO:0006891","GO:0006896","GO:0060291","GO:0051469","GO:0043311","GO:0031629","GO:0048280","GO:0097111","GO:0033194","GO:0006675","GO:0090166","GO:0035493","GO:0016192"]},{"accession":"XP_046448280.1","go_terms":["GO:0006360","GO:0070816","GO:0006289"]},{"accession":"XP_046456097.1","go_terms":["GO:0051024","GO:0061669","GO:0010807","GO:1903358","GO:1903575","GO:0007340","GO:1904050","GO:0010701","GO:2000010","GO:0090161","GO:0097352","GO:1903422","GO:0032258","GO:0098967","GO:1902685","GO:2000463","GO:1903078","GO:0016081","GO:0010811","GO:0006888","GO:0045022","GO:0034498","GO:0001916","GO:0006891","GO:0006896","GO:0060291","GO:0051469","GO:0043311","GO:0031629","GO:0048280","GO:0097111","GO:0033194","GO:0006675","GO:0090166","GO:0035493","GO:0016192"]}],"graph":[["XP_046453262.1","XP_046440173.1",0.973],["XP_046453262.1","XP_046442708.1",0.879],["XP_046453262.1","XP_046445288.1",0.82],["XP_046453262.1","XP_046446223.1",0.604],["XP_046453262.1","XP_046448280.1",0.754],["XP_046453262.1","XP_046455320.1",0.693],["XP_046453262.1","XP_046456618.1",0.884],["XP_046453262.1","XP_046456620.1",0.976],["XP_046453262.1","XP_046456858.1",0.679],["XP_046453262.1","XP_046463736.1",0.918],["XP_046453262.1","XP_046464196.1",0.973],["XP_046456620.1","XP_046437908.1",0.938],["XP_046456620.1","XP_046445288.1",0.93],["XP_046456620.1","XP_046455320.1",0.916],["XP_046456620.1","XP_046456097.1",0.797],["XP_046456620.1","XP_046464196.1",0.924],["XP_046456620.1","XP_046464338.1",0.779],["XP_046456620.1","XP_046463736.1",0.96],["XP_046456620.1","XP_046456858.1",0.742],["XP_046437908.1","XP_046446223.1",0.689],["XP_046437908.1","XP_046440173.1",0.71],["XP_046437908.1","XP_046448280.1",0.888],["XP_046437908.1","XP_046456618.1",0.683],["XP_046456618.1","XP_046445288.1",0.513],["XP_046456618.1","XP_046455320.1",0.813],["XP_046456618.1","XP_046456097.1",0.839],["XP_046456618.1","XP_046464196.1",0.654],["XP_046456618.1","XP_046463736.1",0.843],["XP_046456097.1","XP_046440173.1",0.87],["XP_046456097.1","XP_046446223.1",0.857],["XP_046456097.1","XP_046448280.1",0.794],["XP_046446223.1","XP_046445288.1",0.86],["XP_046446223.1","XP_046455320.1",0.962],["XP_046446223.1","XP_046456858.1",0.963],["XP_046446223.1","XP_046463736.1",0.979],["XP_046456858.1","XP_046440173.1",0.958],["XP_046456858.1","XP_046448280.1",0.834],["XP_046440173.1","XP_046445288.1",0.868],["XP_046440173.1","XP_046442708.1",0.619],["XP_046440173.1","XP_046455320.1",0.864],["XP_046440173.1","XP_046464338.1",0.784],["XP_046440173.1","XP_046463736.1",0.965],["XP_046464338.1","XP_046445288.1",0.861],["XP_046464338.1","XP_046448280.1",0.79],["XP_046464196.1","XP_046445288.1",0.97],["XP_046464196.1","XP_046448280.1",0.75],["XP_046464196.1","XP_046463736.1",0.705],["XP_046445288.1","XP_046442708.1",0.548],["XP_046445288.1","XP_046455320.1",0.758],["XP_046445288.1","XP_046448280.1",0.945],["XP_046445288.1","XP_046463736.1",0.571],["XP_046442708.1","XP_046455320.1",0.569],["XP_046442708.1","XP_046448280.1",0.773],["XP_046455320.1","XP_046448280.1",0.956],["XP_046463736.1","XP_046448280.1",0.819]],"all_go_terms":{"GO:0043308":2,"GO:0090316":2,"GO:0042147":3,"GO:0006891":9,"GO:1900483":2,"GO:0006888":9,"GO:1903595":2,"GO:0090161":9,"GO:0043134":2,"GO:0098967":8,"GO:0042144":3,"GO:0043001":2,"GO:0043320":2,"GO:0035493":8,"GO:0001921":2,"GO:0043312":2,"GO:0016240":2,"GO:0060291":8,"GO:0016079":2,"GO:0070254":2,"GO:0048280":9,"GO:1902259":2,"GO:0032869":2,"GO:0010701":6,"GO:0035774":2,"GO:0061669":6,"GO:0006675":6,"GO:1903078":6,"GO:0043311":6,"GO:1903422":6,"GO:0034498":6,"GO:2000463":6,"GO:0006896":7,"GO:0097111":6,"GO:0006886":3,"GO:1903575":6,"GO:0001916":6,"GO:0007340":6,"GO:0016192":3,"GO:0016081":6,"GO:1902685":6,"GO:0097352":6,"GO:0051469":6,"GO:0045956":2,"GO:0010811":6,"GO:0031321":2,"GO:0033194":6,"GO:0060471":2,"GO:0010807":6,"GO:0032258":6,"GO:0051024":6,"GO:0098917":2,"GO:1903358":6,"GO:0090166":6,"GO:0045022":6,"GO:0050921":2,"GO:2000010":6,"GO:0048791":2,"GO:1904050":6,"GO:0030154":2,"GO:0031629":6,"GO:0008105":1,"GO:0000282":1,"GO:0051666":1,"GO:2000049":1,"GO:0019363":1,"GO:0045892":1,"GO:0006360":3,"GO:0070816":3,"GO:0006289":3,"GO:0045732":1,"GO:0048278":1,"GO:0006623":1,"GO:0050882":1,"GO:0016236":1,"GO:1903076":1},"recipe_readded":[]}