{"hash":"1185106819189586659","title":"Negative Regulators of Developmental Signaling","description":"The cluster centers on GO terms for negative regulation of multiple signaling pathways (ERK cascade, GTPase activity, Ras signaling, FGF receptor signaling) alongside several developmental processes (ureteric bud development, organ induction, axon development, lung branching). This suggests these proteins act as inhibitors that modulate signaling during development, rather than core components, so the label emphasizes both the regulatory role and the developmental context.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"members":[{"accession":"XP_046456648.1","go_terms":["GO:0040037","GO:0016318","GO:0033138","GO:0060437","GO:0010923","GO:0010801","GO:0000188","GO:0007275","GO:0021594","GO:0051387","GO:0051897","GO:0060446","GO:0060449","GO:0008285","GO:0061564","GO:0090311","GO:0034260","GO:0042472","GO:0001759","GO:0046580","GO:0001656","GO:0001657","GO:0045314","GO:0043517","GO:0007426","GO:0000132","GO:0070374","GO:0070373","GO:0060841"]},{"accession":"XP_046461350.1","go_terms":[]},{"accession":"XP_046446387.1","go_terms":["GO:0005975","GO:0090197","GO:0002532","GO:0006032"]},{"accession":"XP_046441647.1","go_terms":[]},{"accession":"XP_046451990.1","go_terms":[]}],"graph":[["XP_046446387.1","XP_046456648.1",0.503],["XP_046441647.1","XP_046456648.1",0.527],["XP_046456648.1","XP_046451990.1",0.652],["XP_046456648.1","XP_046461350.1",0.628]],"all_go_terms":{"GO:0070373":1,"GO:0034260":1,"GO:0040037":1,"GO:0001657":1,"GO:0001759":1,"GO:0061564":1,"GO:0000132":1,"GO:0060449":1,"GO:0046580":1,"GO:0016318":1,"GO:0070374":1,"GO:0010801":1,"GO:0001656":1,"GO:0060437":1,"GO:0010923":1,"GO:0033138":1,"GO:0000188":1,"GO:0043517":1,"GO:0051897":1,"GO:0060446":1,"GO:0007275":1,"GO:0045314":1,"GO:0007426":1,"GO:0042472":1,"GO:0051387":1,"GO:0008285":1,"GO:0060841":1,"GO:0021594":1,"GO:0090311":1,"GO:0006032":1,"GO:0002532":1,"GO:0005975":1,"GO:0090197":1},"recipe_readded":[]}