[{"hash":"810245805462198645","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":25,"triangles":31,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0019878","count":5},{"id":"GO:0006552","count":5},{"id":"GO:0042594","count":4},{"id":"GO:0001889","count":4}]},{"hash":"1997217245969662908","title":"Mitochondrial respiration and apoptosis regulation","description":"The cluster centers on mitochondrial function, with enrichment for assembly of respiratory chain complexes I and II, import of proteins into the mitochondrial matrix, and aerobic respiration. It also includes components involved in cytochrome c release and regulation of apoptotic signaling, and a motif linking to hypoxic response, suggesting a cohesive set of mitochondrial metabolism and apoptosis regulators. The translation term may reflect mitochondrial translation or annotation overlap, but the dominant signal is mitochondrial energy production linked to cell death pathways.","confidence":"High","size":29,"edges":406,"triangles":3654,"max_degree":28,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0030150","count":4},{"id":"GO:0034553","count":2},{"id":"GO:0032981","count":2},{"id":"GO:2001237","count":2}]},{"hash":"854883364213601821","title":"Lipid Remodeling and Biosynthesis","description":"This cluster is dominated by lipid metabolic processes: remodeling of phosphatidylcholine and cardiolipin, ether lipid biosynthesis, and platelet activating factor biosynthesis, with supporting evidence from mitochondrial ATP synthesis. While a few terms relate to development or tissue specificity, the strongest and most frequent GO terms point to lipid remodeling and lipid biosynthesis as the shared theme of this protein group.","confidence":"Medium","size":29,"edges":4,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0036151","count":5},{"id":"GO:2001246","count":5},{"id":"GO:0071260","count":5},{"id":"GO:0010143","count":4},{"id":"GO:0035965","count":4}]},{"hash":"398795431089998043","title":"Cardiovascular development and heart function","description":"These proteins cluster around cardiovascular development and heart-related processes. Several top terms point to heart development and angiogenesis, along with regulation of heart rate by cardiac conduction and blood coagulation. Additional terms for skeletal system and kidney development reflect broader developmental roles, while ERK pathway regulation and MCP-1 production hint at signaling and inflammatory modulation linked to vascular/heart biology. Taken together, the cluster appears to represent a cardiovascular development/heart-function module rather than a single specialized pathway.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0007596","count":4},{"id":"GO:0001822","count":4}]},{"hash":"522002631827393004","title":"Unknown","description":"The terms are diverse and include insect cuticle development, RNA splicing, ubiquitination, and broad/obsolete epigenetic regulation, with no clear, shared function tying the proteins together. The network has no edges, suggesting the cluster isn\u2019t a cohesive functional module. Therefore no specific label can be confidently assigned.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0010226","count":2},{"id":"GO:0000388","count":2},{"id":"GO:0051865","count":1},{"id":"GO:0071158","count":1}]},{"hash":"976869119000796444","title":"Cerebellar neuron differentiation and dendritic spine morphogenesis","description":"The top GO terms cluster around neuronal development and synapse maturation, especially cerebellar granule cell differentiation and positive regulation of dendritic spine morphogenesis. While oligomerization terms are broad protein assembly processes, the cerebellar differentiation and spine morphogenesis signals suggest a neuronal development/synaptogenesis theme, with additional, less-specific regulatory terms (e.g., ERK signaling, cell adhesion, phagocytosis). Overall, the cluster appears to reflect cerebellar neuron development and synaptic maturation.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0051260","count":9},{"id":"GO:0061003","count":9},{"id":"GO:0070208","count":9},{"id":"GO:0021707","count":9},{"id":"GO:0050765","count":9}]},{"hash":"831879947829883478","title":"Ribosome biogenesis and translation","description":"Most top GO terms point to protein synthesis and ribosome assembly (translation, cytoplasmic translation, ribosome biogenesis, ribosomal small subunit biogenesis, tRNA modification). A minority of terms relate to cell cycle/division, which may reflect coordination between growth and division, but the dominant signal is the ribosome/translation machinery.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0042254","count":5},{"id":"GO:0006400","count":4},{"id":"GO:0002181","count":4},{"id":"GO:0007049","count":4}]},{"hash":"1967647585278692944","title":"Skeletal muscle and cartilage development","description":"Based on the top GO terms, the cluster is dominated by skeletal muscle tissue and muscle fiber development, as well as cartilage morphogenesis and axis patterning (left/right formation), pointing to a musculoskeletal development theme; a few terms (e.g., phototropism, certain ubiquitination processes) appear to be noise or misannotations, but the core signal supports musculoskeletal formation.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900477","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0060972","count":2},{"id":"GO:1990390","count":2},{"id":"GO:0060536","count":2}]},{"hash":"1345103483838729454","title":"Developmental Regulation and Complement Activation","description":"This cluster is enriched for multiple developmental processes (midbrain, cartilage, spleen, heart, and multicellular organism development) and for negative regulation of transcription by RNA polymerase II, indicating transcriptional control during development. It also includes complement activation terms (classical and lectin pathways), suggesting some immune-related activity within the group. The dominant theme appears to be developmental regulation with regulatory (transcriptional) control, with an accompanying but secondary immune/complement signal.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0030901","count":8},{"id":"GO:0006958","count":7},{"id":"GO:0014068","count":6},{"id":"GO:0001867","count":6}]},{"hash":"414415889266556847","title":"Actin Cytoskeleton Remodeling and Cell Junction Assembly","description":"The top GO terms point to actin-driven structures and organization (lamellipodium, Rho signaling, tubulin complex) along with cell\u2013cell adhesion components (adherens and tight junctions). This suggests a coherent theme of cytoskeletal dynamics underlying junction formation and maintenance, with a few peripheral signals (B cell receptor signaling, oxidative response) that may reflect broader signaling context. Overall, a cohesive label around cytoskeleton remodeling and junction assembly fits best.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":3},{"id":"GO:0007266","count":3},{"id":"GO:0043552","count":3},{"id":"GO:2000301","count":3},{"id":"GO:0050853","count":3}]},{"hash":"1623269368455581474","title":"DNA integration and proviral latency","description":"This cluster is dominated by GO terms tied to DNA metabolism and genome manipulation (DNA integration, DNA recombination, DNA-templated transcription, DNA replication) and clearly features proviral latency and viral entry into the host nucleus, plus related host-symbiont interaction terms. While skeletal muscle and heart development terms appear, the core signal centers on DNA processing and retroviral integration/latency, suggesting a cohesive theme around genome manipulation by viruses/symbionts. ","confidence":"Medium","size":29,"edges":15,"triangles":8,"max_degree":6,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0006310","count":5},{"id":"GO:0007519","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0006351","count":5}]},{"hash":"2236959259040729287","title":"Hormone-driven organ development and xenobiotic metabolism","description":"The top terms cluster around reproductive hormone pathways (female gonad development, androgen metabolic process, testosterone biosynthetic process) and organ development (heart development, retina vasculature development), with metabolic/detoxification and stress-related responses (xenobiotic catabolic process, response to immobilization stress, response to vitamin D, negative regulation of chronic inflammatory response). This pattern suggests proteins involved in hormonal regulation of organ development coupled with metabolic and detoxification functions, rather than a single narrow process.","confidence":"Medium","size":29,"edges":8,"triangles":2,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008585","count":8},{"id":"GO:0008209","count":6},{"id":"GO:0061370","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0002677","count":5}]},{"hash":"1136363074405906227","title":"Secretory pathway trafficking and cell growth","description":"This cluster centers on proteins involved in the secretory pathway (COPII vesicle budding; Golgi to ER; Golgi to plasma membrane) and general cell growth/proliferation signals. The prominent GO terms indicate active membrane trafficking essential for growth and development, including brain development, aligning with vesicle transport functions. ","confidence":"High","size":29,"edges":28,"triangles":3,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035264","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0008283","count":6},{"id":"GO:0055091","count":6},{"id":"GO:0006890","count":6}]},{"hash":"2114667772714193118","title":"mRNA Processing and Translation Regulation","description":"This cluster is dominated by GO terms related to translation initiation, initiation factor complex assembly, and regulation of translational initiation, along with mRNA stabilization and splicing-related processing, pointing to a cohesive post-transcriptional regulatory program affecting mRNA maturation and translation.","confidence":"High","size":29,"edges":7,"triangles":0,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":16},{"id":"GO:0002188","count":15},{"id":"GO:0031047","count":15},{"id":"GO:0048026","count":15},{"id":"GO:0045292","count":12}]},{"hash":"1761168349390411924","title":"Complement activation and coagulation in immune defense","description":"The prominent GO terms point to complement activation (lectin and classical pathways) and defense against bacteria, along with blood coagulation, indicating a cohesive immune-coagulation module. Additional terms related to development and matrix remodeling are present but do not override the central immunological theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0035264","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0007338","count":6},{"id":"GO:0007596","count":5}]},{"hash":"1226545711247265382","title":"Rho GTPase\u2013driven actin remodeling","description":"The cluster is enriched for terms tied to small GTPase signaling and actin cytoskeleton dynamics, including positive regulation of GTPase activity, small GTPase-mediated signal transduction, lamellipodium/microspike assembly, and barbed-end actin capping. While there are related signals such as TGF-beta response and apoptosis, the strongest common theme across the proteins is regulation of actin remodeling by Rho-family GTPases, suggesting a cohesive role in cytoskeletal dynamics.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0071560","count":5},{"id":"GO:0006915","count":5},{"id":"GO:0030032","count":5},{"id":"GO:0050731","count":4}]},{"hash":"771138877382453069","title":"Wnt signaling and angiogenesis with innate immunity","description":"The cluster shows strong enrichment for Wnt signaling (GO:0016055) and positive regulation of angiogenesis (GO:0045766), along with innate immune responses (defense response to Gram-positive bacterium; response to lipopolysaccharide) and development-related terms (midbrain development). Together, this points to proteins involved in developmental signaling that modulate angiogenesis and immune interactions, with neural development context. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0014068","count":9},{"id":"GO:0016055","count":8},{"id":"GO:0045766","count":8},{"id":"GO:0050830","count":8},{"id":"GO:0071333","count":8}]},{"hash":"2064562475068207788","title":"Proviral integration and host manipulation","description":"This cluster centers on GO terms tied to viral/proviral life cycles and how they interact with the host cell, including DNA replication and integration, RNA-templated DNA biosynthesis, viral entry into the nucleus, and establishment of proviral latency, alongside host apoptosis signaling and symbiont entry. These collectively point to a theme of viral genome integration and manipulation of host cell processes, with some auxiliary functions like ubiquitination appearing as broader cellular contexts.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006278","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3}]},{"hash":"157505110591113730","title":"Vertebrate embryonic organogenesis","description":"The top GO terms point to embryonic development across multiple tissues (pituitary, midbrain, hindlimb, eye, heart outflow tract, primitive streak), with an additional broad regulatory term for transcription by RNA Pol II, suggesting proteins that coordinate gene expression during embryogenesis. Confidence in this thematic label is High.","confidence":"High","size":29,"edges":44,"triangles":0,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0021983","count":9},{"id":"GO:0030901","count":9},{"id":"GO:0090009","count":9},{"id":"GO:2000288","count":8}]},{"hash":"1295290945746680790","title":"ER-Golgi Vesicle Trafficking and Growth","description":"The top GO terms center on intracellular vesicle transport, especially ER-to-Golgi and Golgi-to-ER trafficking, plus endosome-to-melanosome transport, with accompanying growth and proliferation terms (multicellular growth, cell division, cell population proliferation). This indicates a cohesive theme of vesicle trafficking machinery that also relates to cellular growth processes.","confidence":"High","size":29,"edges":3,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006888","count":7},{"id":"GO:0035264","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0008283","count":6},{"id":"GO:0042254","count":6}]},{"hash":"1587761705400454883","title":"Developmental gene expression and protein quality control","description":"This cluster shows enrichment for gene expression processes (DNA-templated transcription and initiation of translation), plus protein ubiquitination and ERAD-related pathways, ER-to-Golgi trafficking, and development-related terms (skeletal system and male gonad development). The mix suggests a cohesive theme around how gene expression and proteostasis are coordinated during development, with additional stress/defense signals (cadmium response and Gram-positive defense). Hence a label focused on developmental gene expression and protein quality control seems most representative, though the diversity keeps the confidence moderate.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0035264","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0001501","count":4}]},{"hash":"2192626108549895709","title":"Unknown","description":"The top GO terms are highly diverse (vitamin D response, phosphorylation regulation, hypoxia, aging, lens differentiation, transcription, defense to bacterium) and many are obsolete, with no clear unifying function or network connectivity. Thus there is no coherent theme to label the cluster beyond Unknown.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033280","count":4},{"id":"GO:0033138","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0031915","count":3},{"id":"GO:0071456","count":3}]},{"hash":"1929566728289203774","title":"Larval cuticle development and ER-Golgi trafficking","description":"The top GO term is larval chitin-based cuticle development with 16 proteins, suggesting a strong link to larval cuticle formation. The presence of terms related to ER-to-Golgi transport, ribosome biogenesis, actin nucleation, translation regulation, and cell-cycle control indicates the cluster also encompasses core cellular processes that often accompany developmental programs. Taken together, this set appears to center on larval cuticle development while reflecting broader cellular machinery.","confidence":"Medium","size":28,"edges":368,"triangles":3032,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":16},{"id":"GO:0006888","count":2},{"id":"GO:0061099","count":1},{"id":"GO:0006446","count":1},{"id":"GO:1901976","count":1}]},{"hash":"753458507554441180","title":"Ubiquitin-regulated signaling and secretion","description":"This cluster centers on regulatory processes that modify protein fate and signaling, highlighted by ubiquitin-dependent protein catabolic process and negative regulation of ubiquitination, plus ERK/MAPK\u2013driven signaling and positive regulation of protein secretion. Additional terms touch on intracellular transport, angiogenesis, platelet maturation, and dendritic cell differentiation, suggesting a broader theme of coordinated protein turnover and signal transduction in immune-vascular contexts.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":3},{"id":"GO:2000312","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0031397","count":3},{"id":"GO:0006886","count":2}]},{"hash":"758861670561259139","title":"Nuclear transport and developmental signaling","description":"This cluster is strongly enriched for GO terms tying nuclear import (NLS-bearing protein import into nucleus) to developmental signaling processes (epithelial/prostate/root development, Wnt signaling, EMT) and related regulatory activities (GTPase regulation, mitochondrial calcium, DNA damage response). Although some terms are broader (proton transport, host\u2013symbiont responses), the core theme appears to be proteins coordinating nuclear transport with signaling pathways that govern development and cell fate, with supporting roles in stress responses. ","confidence":"Medium","size":28,"edges":373,"triangles":3152,"max_degree":27,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0006607","count":23},{"id":"GO:0043547","count":23},{"id":"GO:0015991","count":23},{"id":"GO:0060769","count":22},{"id":"GO:0048364","count":22}]},{"hash":"1208539916191454086","title":"Retina development and photoreceptor GPCR signaling","description":"This cluster is dominated by retina-related terms (retina development, photoreceptor maintenance) and GPCR signaling terms (GPCR internalization, arrestin desensitization, dopamine signaling, adrenergic receptor pathways), indicating a cohesive group of photoreceptor-specific GPCR signaling proteins and associated retina maintenance processes.","confidence":"High","size":28,"edges":14,"triangles":2,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0008283","count":24},{"id":"GO:0060041","count":24},{"id":"GO:0008284","count":24},{"id":"GO:0043547","count":24},{"id":"GO:0031635","count":22}]},{"hash":"1152817763947612460","title":"Ubiquitin-Proteasome Proteostasis in Insect Development","description":"The cluster heavily features ubiquitin-proteasome\u2013linked proteolysis and protein quality control terms (e.g., ubiquitin-dependent catabolic process, nuclear quality control), pointing to a proteostasis module. It also includes insect-development terms (larval cuticle development, photoreceptor organization), suggesting this proteostasis machinery supports developmental processes in insects. Some terms are obsolete or broad, but the overall theme links regulated protein turnover to insect development.","confidence":"Medium","size":28,"edges":339,"triangles":2455,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":16},{"id":"GO:0030433","count":1},{"id":"GO:0070301","count":1},{"id":"GO:0071357","count":1},{"id":"GO:0016570","count":1}]},{"hash":"1495831929793365092","title":"Ubiquitin-Proteasome Regulation","description":"This cluster is dominated by GO terms related to ubiquitin removal and protein turnover, notably K11-linked and histone H2A deubiquitination, as well as proteolysis and cell cycle. These themes point to involvement in ubiquitin-dependent protein degradation and regulation of protein stability and chromatin remodeling, making \u201cUbiquitin-Proteasome Regulation\u201d a representative label. Some other terms reflect broader stress or metabolic responses but do not outcompete the central ubiquitination/deubiquitination signal.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035871","count":4},{"id":"GO:0043278","count":3},{"id":"GO:0070537","count":3},{"id":"GO:0035522","count":3},{"id":"GO:0006508","count":3}]},{"hash":"2026328106408890203","title":"Steroid and pigment biosynthesis","description":"The top GO terms center on hormone-related biosynthesis (androgen and glucocorticoid pathways) and pigment formation (retinal metabolism, melanin biosynthesis), suggesting a cluster of proteins involved in synthesizing steroids and pigments. Additional terms for fatty acid elongation and tetrahydrobiopterin biosynthesis reflect broader metabolic enzyme activities that support these biosynthetic processes. Overall, the cluster seems driven by steroid and pigment biosynthesis rather than a single unified pathway.","confidence":"Medium","size":28,"edges":5,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0042619","count":7},{"id":"GO:0008209","count":6},{"id":"GO:0006710","count":6},{"id":"GO:0006729","count":6}]},{"hash":"146127969129457383","title":"Bone formation and ECM remodeling","description":"Top terms cluster around ossification, collagen breakdown, and basement membrane remodeling, pointing to bone development and extracellular matrix turnover, with associated morphogenesis and signaling (Wnt, thyroid hormone) suggesting broader developmental regulation. Protein quality control terms (ubiquitin/ERAD, aggresome) hint at turnover-related regulation of these processes. Overall, the theme is bone formation and ECM remodeling during development.","confidence":"Medium","size":28,"edges":366,"triangles":2984,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":11},{"id":"GO:0016579","count":10},{"id":"GO:0070842","count":9},{"id":"GO:0001957","count":8},{"id":"GO:0060441","count":8}]},{"hash":"1397069658716956488","title":"Neural development and transcriptional regulation","description":"The cluster is enriched for neural differentiation and fate specification in the spinal cord and brain (spinal cord motor neurons, oligodendrocyte and interneuron differentiation, subpallium fate commitment, cerebral cortex GABAergic interneurons) along with transcriptional control terms (RNA polymerase II\u2013mediated transcription, transcription factor activity regulation) and circadian regulation of gene expression, suggesting a cohesive theme of CNS development coupled with gene regulation. ","confidence":"High","size":28,"edges":375,"triangles":3201,"max_degree":27,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045668","count":19},{"id":"GO:0006366","count":19},{"id":"GO:0060766","count":19},{"id":"GO:0021520","count":18},{"id":"GO:0032922","count":18}]},{"hash":"1075772468510341864","title":"Unknown","description":"The top GO terms span neural differentiation (cerebellar granule cell differentiation) and a mix of regulatory, metabolic, and signaling processes (cell adhesion regulation, ERK/MAPK signaling, Wnt signaling, fatty acid oxidation, cholesterol efflux, aldosterone secretion, hypochlorous acid biosynthesis, protein oligomerization), with no clear single function tying them together. This suggests the cluster represents diverse, possibly heterogeneous functions rather than a cohesive biological module.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":5},{"id":"GO:0034115","count":4},{"id":"GO:0033034","count":3},{"id":"GO:2000860","count":3},{"id":"GO:0070373","count":3}]},{"hash":"735986998188437039","title":"Neural Development and Nervous System Formation","description":"This cluster centers on neural development, with forebrain development, neural tube closure, and nervous system development dominating, along with broader multicellular organism development and DNA-templated transcription. The terms suggest coordinated transcriptional programs driving neural organogenesis, with occasional links to ER-stress\u2013related apoptosis and cell-cycle regulation that may occur during development. Overall, the dominant theme is neural development.","confidence":"Medium","size":28,"edges":91,"triangles":61,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007584","count":7},{"id":"GO:0030900","count":6},{"id":"GO:0001843","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0070059","count":6}]},{"hash":"2158213536790915618","title":"Metabolic biosynthesis and catabolic processes","description":"This cluster shows enrichment for a range of biosynthetic and degradative pathways (e.g., menaquinone, biotin, antibiotic biosynthesis; glutaminyl-tRNAGln biosynthesis; fatty acid and phenylacetate catabolism) and even mitochondrial translation and ER organization terms. The common theme appears to be broad metabolic functions spanning synthesis and breakdown across cellular compartments, rather than a single cohesive pathway. ","confidence":"Medium","size":28,"edges":15,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032543","count":7},{"id":"GO:0009234","count":7},{"id":"GO:0070681","count":5},{"id":"GO:0009062","count":5},{"id":"GO:0007029","count":5}]},{"hash":"1207190453730655928","title":"Developmental and Immune Regulation","description":"This cluster centers on transcriptional regulation (negative regulation of transcription by RNA polymerase II and regulation of DNA-templated transcription) alongside developmental signals (midbrain development, in utero embryonic development, multicellular organism growth) and innate immune responses (complement activation via the classical pathway, defense against Gram-positive bacteria, lipopolysaccharide response) with plasminogen activation linking tissue remodeling. The co-occurrence of transcriptional control, development, and immune-related GO terms suggests proteins involved in regulating gene expression during development and innate immunity. Confidence: Medium","confidence":"","size":28,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0006355","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0032496","count":6},{"id":"GO:0030901","count":5}]},{"hash":"1609008313059390486","title":"Actin Cytoskeleton Remodeling and Lamellipodium Assembly","description":"This cluster is driven by strong actin dynamics signals\u2014polymerization, nucleation, various capping and severing activities, and lamellipodium assembly\u2014along with Rac-mediated signaling, pointing to a cohesive role in actin cytoskeleton remodeling and cell motility. The larval cuticle development term is present but seems less central to the core actin-focused function of the group.","confidence":"High","size":28,"edges":282,"triangles":1456,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":7},{"id":"GO:0030041","count":4},{"id":"GO:0045010","count":3},{"id":"GO:0051016","count":3},{"id":"GO:0010592","count":3}]},{"hash":"557345651593257101","title":"Ubiquitin-Proteostasis and Protein Processing","description":"The dominant terms center on ubiquitin-related pathways (ubiquitin-dependent ERAD, regulation of deubiquitination) plus protein processing steps (autoprocessing, APP regulation, angiotensin maturation) and apoptosis execution. This suggests a cohesive theme of ubiquitin-regulated proteostasis and signaling, with a few outliers like xylan catabolic process appearing as noise.","confidence":"Medium","size":28,"edges":82,"triangles":101,"max_degree":17,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0030433","count":7},{"id":"GO:0030512","count":5},{"id":"GO:1903094","count":5},{"id":"GO:2000157","count":5},{"id":"GO:0097194","count":4}]},{"hash":"191413937135726214","title":"Embryonic organ development and patterning","description":"Top GO terms collectively point to morphogenesis and development across multiple embryonic tissues (palate, digits, midbrain, limbs, skeletal system, pituitary, cerebral cortex regionalization, heart outflow tract). The inclusion of transcriptional regulation terms further supports regulatory programs driving organogenesis during development. This suggests the cluster represents proteins involved in broad embryonic morphogenesis and patterning rather than a single pathway.","confidence":"High","size":28,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":2},{"id":"GO:0042733","count":2},{"id":"GO:0030901","count":2},{"id":"GO:0035116","count":2},{"id":"GO:0048706","count":2}]},{"hash":"154413390830420696","title":"Neural and Skeletal Development","description":"Explanation: Dominant signals are neural development (cerebellar granule cell differentiation, cerebral cortex development, inner ear development, synapse assembly) and skeletal differentiation (cartilage condensation, chondrocyte differentiation). Protein oligomerization terms may reflect multi-subunit complexes common in developmental processes, with some additional terms like blood coagulation likely representing broader roles.","confidence":"High","size":28,"edges":2,"triangles":0,"max_degree":1,"top_function":"wound healing","top_go_terms":[{"id":"GO:0007596","count":7},{"id":"GO:0021707","count":7},{"id":"GO:0051965","count":6},{"id":"GO:0048839","count":6},{"id":"GO:0051260","count":6}]},{"hash":"493371681759692967","title":"Coagulation, complement activation, and ECM regulation","description":"The top GO terms point to hemostasis (blood coagulation) and immune-related processes (complement activation, regulation of macrophage differentiation) along with extracellular matrix remodeling (collagen fibril organization). There are also signaling and synaptic-related terms suggesting broader regulatory roles. Together, these indicate a cluster of proteins involved in coagulation/immune signaling and ECM processes rather than a single, narrow pathway, justifying a label that emphasizes coagulation, immune activity, and ECM regulation.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0030853","count":3},{"id":"GO:2000534","count":3},{"id":"GO:0045715","count":3},{"id":"GO:0061003","count":3}]},{"hash":"530438967519881456","title":"Androgen-driven steroid and xenobiotic metabolism","description":"The cluster\u2019s top GO terms center on androgen metabolic processes and prostate-related growth, supported by fatty acid omega-oxidation, xenobiotic and vitamin D catabolic processes, and methylation. These together suggest a shared theme of steroid-related metabolism and detoxification pathways, with broader implications for lipid metabolism and endocrine regulation. A couple of terms (endothelial adhesion, immobilization stress, cesium ion response) appear as broader cellular contexts, but the core signal points to androgen- and xenobiotic-metabolic functions.","confidence":"Medium","size":28,"edges":46,"triangles":4,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":17},{"id":"GO:0035865","count":17},{"id":"GO:0010430","count":17},{"id":"GO:0060736","count":17},{"id":"GO:0071603","count":17}]},{"hash":"2123997931061256765","title":"Cell division and apoptosis regulation","description":"This cluster is dominated by GO terms related to mitosis and cell cycle (cell division, mitotic spindle assembly, leading strand elongation) and apoptosis (apoptotic process), with additional signals toward developmental regulation (negative regulation of Notch signaling) and cell polarity. Together, these suggest a core theme around cell proliferation and programmed cell fate decisions, with ancillary links to protein homeostasis and aging-related processes.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0045746","count":3},{"id":"GO:0090307","count":2}]},{"hash":"439076078893196347","title":"Ubiquitin-Proteasome Degradation","description":"The dominant GO terms are all about ubiquitin-dependent protein catabolic processes (ERAD, K48-linked ubiquitination, autoubiquitination), indicating this cluster centers on ubiquitin-mediated proteolysis and protein quality control, with some auxiliary terms reflecting regulatory or signaling contexts.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0030433","count":9},{"id":"GO:0070936","count":8},{"id":"GO:0051865","count":7},{"id":"GO:0046621","count":7}]},{"hash":"2021254803313108844","title":"Developmental growth and proliferation signaling","description":"The top GO terms center on growth and morphogenesis (hair follicle morphogenesis, spermatid development, multicellular organism growth) and proliferation (cell division, cell population proliferation), with supportive roles from ERK signaling and vesicle trafficking (endocytic recycling) and ribosomal export. This suggests a cohesive theme of proteins coordinating growth and developmental processes through signaling and trafficking pathways, rather than a single narrowly defined function.","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000055","count":7},{"id":"GO:0010796","count":7},{"id":"GO:0031384","count":7},{"id":"GO:0031069","count":6},{"id":"GO:0032456","count":6}]},{"hash":"1343521366595611310","title":"Embryonic Development and Tissue Morphogenesis","description":"The top GO terms cluster around developmental programs across multiple tissues\u2014endocrine system development, left-right patterning, cartilage morphogenesis, placental and trophoblast differentiation, and EMT during heart development\u2014indicating a common theme of embryogenesis and tissue morphogenesis. Some terms touch on cell cycle and transcription, but the dominant pattern is developmental differentiation and organogenesis.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0060806","count":2}]},{"hash":"2192565683165057940","title":"Genotoxic Stress Response","description":"This cluster is dominated by GO terms tied to DNA damage and stress signaling: SOS response, double-strand break repair via classical nonhomologous end joining, DNA replication, ionizing radiation response, and xenobiotic response, with additional signals related to ERK cascade regulation. These collectively point to a chromosomal integrity and cellular stress\u2013signaling theme. Some terms like B cell receptor signaling and nodulation seem ancillary or cross-domain, but the core signal is genotoxic stress response.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":2},{"id":"GO:0009877","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0010212","count":2},{"id":"GO:0009432","count":2}]},{"hash":"2046286341603944513","title":"Cell Cycle and Ribosome Biogenesis","description":"The most represented GO terms cluster around cell division, cell cycle, exit from mitosis, and ribosome biogenesis, all hallmark processes of proliferating cells and increased protein synthesis capacity. The presence of Rac signaling and multivesicular body sorting suggests associated cytoskeletal regulation and vesicle trafficking linked to division. A few peripheral terms (defense response to protozoan) exist but do not dominate. So the core theme is growth and division machinery.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0098707","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0010458","count":2}]},{"hash":"410164686377935604","title":"Proteostasis and cell-cycle signaling","description":"The cluster combines proteins involved in ubiquitin-dependent protein degradation (proteostasis), heat/temperature stress responses, and cell-cycle related processes (spindle assembly and telomere maintenance). It also includes signaling-related GO terms (Wnt pathway, vitamin D response) and RNA processing activities, suggesting a cohesive theme around maintaining cellular homeostasis while coordinating cell division and gene expression.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0009408","count":8},{"id":"GO:0032212","count":7},{"id":"GO:0051225","count":7},{"id":"GO:0033280","count":6}]},{"hash":"1163874337707922316","title":"Organogenesis and tissue remodeling","description":"The top GO terms point to organ development and growth (pancreas morphogenesis, midbrain development, multicellular organism growth, regulation of cell proliferation) with supporting roles in ECM remodeling (elastin catabolic process) and immune/tissue interactions (defense response to Gram-positive bacterium, leukocyte tethering). This suggests a cohesive theme of developmental morphogenesis and extracellular remodeling, even though the dataset shows diverse processes. Edges are absent here, indicating limited interaction data for this cluster.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0035264","count":10},{"id":"GO:0050830","count":10},{"id":"GO:0014068","count":10},{"id":"GO:0061113","count":10}]},{"hash":"276484116155352560","title":"DNA Replication and Transcription Regulation","description":"Many top GO terms cluster around DNA-centric processes: DNA replication, DNA recombination, and DNA-templated transcription, plus regulation of transcription by RNA polymerase II. Although some terms point to development and ubiquitination, the dominant signal is nuclear DNA metabolism and transcription control, justifying a label focused on replication and transcription regulation.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0050853","count":3},{"id":"GO:0001890","count":3}]},{"hash":"1011583775563963365","title":"RNA capping and cell division regulators","description":"The top GO terms center on mRNA capping and cell division (mitotic chromatid separation, cell division), with supporting hints from helicase regulation, ER-Golgi transport, and lysine methylation, implying a functional link between RNA processing and cell-cycle control.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":4},{"id":"GO:0051306","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0051096","count":3}]},{"hash":"1489369983066872530","title":"Rho GTPase and GPCR Signaling Regulators","description":"The top GO terms point to modulation of GTPase activity and Rho signaling, along with desensitization of GPCR signaling and thrombin receptor pathways, suggesting the proteins act as regulators of GPCR- and Rho-mediated signaling. Development-related terms likely reflect broader roles but do not outweigh the core signaling theme.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090630","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0007507","count":3},{"id":"GO:2000009","count":3},{"id":"GO:0002029","count":2}]},{"hash":"1072343478306312607","title":"Mitochondrial energy production and lipid metabolism","description":"Proteins in this cluster are strongly associated with oxidative phosphorylation and ATP synthesis driven by the proton motive force, including mitochondrial ATP synthesis and ubiquinone biosynthesis. Lipid metabolic processes and lipid homeostasis further support a role in membrane-associated energy production and lipid regulation. A few terms appear unrelated (e.g., Purkinje cell layer morphogenesis), indicating some noise, but the dominant signal points to mitochondrial respiration and lipid metabolism.","confidence":"Medium","size":27,"edges":193,"triangles":539,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0099132","count":2},{"id":"GO:0042777","count":2},{"id":"GO:0042775","count":2},{"id":"GO:0006629","count":2}]},{"hash":"284782249218518386","title":"Mitochondrial Translation and Bioenergetics","description":"This cluster is dominated by mitochondrial-related functions: translation and tRNA methylation (protein synthesis in mitochondria), proton motive force-driven ATP synthesis, cytochrome c release regulation, and mitochondrion morphogenesis. Quinone biosynthesis terms also tie into electron transport, supporting a mitochondrial energy-production theme. Some neuronal development terms are present but appear incidental to the main mitochondrial signal. Overall, the cluster aligns with mitochondrial protein synthesis and energy metabolism. ","confidence":"High","size":27,"edges":351,"triangles":2925,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0070584","count":3},{"id":"GO:0009102","count":2},{"id":"GO:0030488","count":2}]},{"hash":"98865779145658459","title":"Redox Homeostasis and Oxidative Stress Response","description":"Based on the strong enrichment for cellular oxidant detoxification, cell redox homeostasis, and hydrogen peroxide\u2013related processes, the cluster appears to coordinate antioxidant defenses and ROS signaling. Some ECM and erythrocyte-related terms may reflect broader tissue-context effects of redox balance, but the dominant theme is redox maintenance and detoxification.","confidence":"High","size":27,"edges":297,"triangles":1852,"max_degree":26,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0098869","count":15},{"id":"GO:0045454","count":13},{"id":"GO:0055114","count":9},{"id":"GO:0030416","count":9},{"id":"GO:2000255","count":8}]},{"hash":"228708761706447376","title":"Far-red light signaling and circadian transcription regulation","description":"This cluster is dominated by terms for far-red light perception and signaling (red/far-red phototransduction, far-red signaling) and for transcriptional/circadian regulation (regulation of DNA-templated transcription, positive regulation of circadian rhythm), suggesting a light-entrained transcriptional/clock module. Additional terms for translation and endocytosis hint at broader cellular signaling roles, but the core theme centers on light signaling and circadian control.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009585","count":2},{"id":"GO:0010018","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0042753","count":2},{"id":"GO:0016055","count":2}]},{"hash":"22289142152254283","title":"Viral life cycle and proviral latency","description":"The top GO terms cluster around virus-related processes: entry into the host, virion assembly, and release, along with establishment of integrated proviral latency, which points to the viral infection cycle and host\u2013virus interactions. Transcription-related terms (DNA-templated transcription) and histone acetylation hints (even if labeled obsolete) suggest epigenetic regulation of viral gene expression and latency. Overall, this set most coherently labels a viral life cycle/latency theme.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0075713","count":3},{"id":"GO:0030260","count":3},{"id":"GO:0019068","count":3},{"id":"GO:0019076","count":3},{"id":"GO:0006351","count":3}]},{"hash":"734306822180502900","title":"Nuclear transport and pore assembly","description":"The proteins are enriched for nuclear transport activities (NLS-bearing protein import into nucleus, ribosomal protein import, mRNA export) and nuclear pore complex assembly, with related regulatory processes (GTPase activity, desumoylation). A secondary hint of intraciliary transport also points to broader transport roles. Therefore, a concise label is Nuclear transport and pore assembly.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":8},{"id":"GO:0006607","count":7},{"id":"GO:0006610","count":7},{"id":"GO:0035735","count":6},{"id":"GO:0060188","count":6}]},{"hash":"2014319400353556953","title":"mRNA processing and translation initiation regulation","description":"The terms cluster around mRNA processing (splicing, splice site recognition, alternative splicing), mRNA stability and stabilization, and initiation of translation (preinitiation complex formation, eIF4F complex assembly, regulation of translational initiation), with links to regulatory ncRNA-mediated silencing. This points to a cohesive module of post-transcriptional gene regulation affecting splicing and the translation machinery, especially under stress.","confidence":"High","size":27,"edges":127,"triangles":119,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":21},{"id":"GO:0006378","count":17},{"id":"GO:0045292","count":17},{"id":"GO:0031047","count":17},{"id":"GO:0000381","count":16}]},{"hash":"334368791212298688","title":"Multicellular development and transcription","description":"The top terms mainly point to developmental processes (forebrain development, skeletal system development, neural tube closure, multicellular organism development) and transcription-related activities (DNA-templated transcription, mitotic cell cycle), suggesting a developmental gene-expression program. A few non-developmental terms exist (defense response to Gram-positive bacterium, cellular response to cadmium ion), but they are less representative of the cluster\u2019s core theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050830","count":11},{"id":"GO:0030900","count":9},{"id":"GO:0001501","count":9},{"id":"GO:0001403","count":9},{"id":"GO:0071276","count":9}]},{"hash":"1940081304763989177","title":"Glycosylation and proteoglycan biosynthesis cluster","description":"The top GO terms emphasize glycosylation processes (protein glycosylation, N-glycan fucosylation) and keratan sulfate proteoglycan biosynthesis, indicating carbohydrate processing and glycan assembly as the primary theme. While there are immune and neural migration terms present, the strongest signals are tied to glycan biosynthesis and proteoglycan production, justifying a label focused on glycosylation. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":6},{"id":"GO:0010493","count":5},{"id":"GO:0002361","count":4},{"id":"GO:0002522","count":4},{"id":"GO:0036071","count":4}]},{"hash":"2058644014696368683","title":"Plant cell wall glycoprotein biosynthesis","description":"The top GO terms point strongly to plant extracellular matrix and glycoprotein production: arabinogalactan protein metabolism, hydroxyproline O-linked glycosylation, and mucilage biosynthesis, plus developmental processes like root hair cell development and seed coat mucilage formation. Although a few terms are from non-plant contexts, the dominant signal fits a cluster of glycoprotein-related cell wall biosynthesis and modification, especially involving AGPs and related glycosylation pathways.","confidence":"Medium","size":27,"edges":49,"triangles":5,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":10},{"id":"GO:0010493","count":6},{"id":"GO:0001744","count":6},{"id":"GO:0030311","count":6},{"id":"GO:0042248","count":6}]},{"hash":"1442533843637371077","title":"Lipid Metabolism and Lipoprotein Remodeling","description":"The GO terms are dominated by lipid-related processes: triglyceride catabolism and biosynthesis, lipid digestion, cholesterol homeostasis, intestinal cholesterol absorption, HDL clearance, and VLDL particle remodeling, plus phospholipid homeostasis. Together they point to a core theme of lipid metabolism and lipoprotein processing, with a potential minor secondary signal of cellular defense that may be incidental noise.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":10},{"id":"GO:0044241","count":6},{"id":"GO:0019432","count":6},{"id":"GO:0006968","count":6},{"id":"GO:0030299","count":6}]},{"hash":"1095840361669598988","title":"Epigenetic Regulation and Developmental Signaling","description":"The cluster centers on transcriptional control and chromatin remodeling (negative regulation of RNA Pol II transcription; chromatin remodeling) together with key developmental and signaling pathways (Wnt, insulin receptor signaling) and differentiation processes (forebrain radial glial cell differentiation; spermatid nucleus differentiation; multicellular growth). This suggests proteins involved in regulating gene expression during development via epigenetic and signaling mechanisms. Some terms (complement activation, blood coagulation) appear tangential and may reflect multifunctionality or data noise, but do not override the core developmental/regulatory theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0016055","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0007596","count":3}]},{"hash":"2252256484311374615","title":"Embryonic Development and Tissue Morphogenesis","description":"This cluster centers on diverse embryonic development processes\u2014pancreatic beta cell development, left-right patterning, placental and cartilage morphogenesis, trophoblast differentiation, and EMT in heart formation\u2014suggesting a broad role in organogenesis. The presence of spliceosome-mediated mRNA splicing and transcriptional regulation terms reflects gene-expression programs that coordinate these developmental events.","confidence":"High","size":27,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0003323","count":9},{"id":"GO:0060972","count":9},{"id":"GO:0035270","count":9},{"id":"GO:0060806","count":9},{"id":"GO:0060536","count":9}]},{"hash":"1401084788483410209","title":"Unknown","description":"The GO terms are very diverse (lipid and carbohydrate catabolism, xenobiotic response, transcription, brain development, endocannabinoid signaling, cellulose catabolism, etc.) and there is no clear single function tying the proteins together; the lack of edges further suggests annotation noise rather than a cohesive cluster.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019433","count":4},{"id":"GO:0017000","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0097011","count":3}]},{"hash":"1745023932446097775","title":"Craniofacial cartilage and hair follicle development","description":"The top GO terms cluster around craniofacial morphogenesis: palatal roof development, cartilage condensation, collagen fibril organization, and BMP signaling response, plus hair follicle development/morphogenesis. These indicate a coherent developmental module governing craniofacial cartilage formation and skin appendages, with extracellular matrix remodeling and BMP pathways as central processes. A few terms (pancreatic development, extrinsic apoptotic signaling, potassium transport) are less central and may reflect broader signaling contexts or pleiotropy.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":3},{"id":"GO:0002053","count":3},{"id":"GO:0001502","count":3},{"id":"GO:0030199","count":3},{"id":"GO:1902043","count":3}]},{"hash":"1537161289109925224","title":"Translation and Central Metabolism","description":"This cluster shows strong representation of translation (protein synthesis) terms, alongside several central carbon metabolism and biosynthetic processes (glycolysis, TCA cycle, glyoxylate cycle, NADPH regeneration, biotin biosynthesis, antibiotic biosynthesis). The mix suggests a cluster associated with core cellular growth and metabolic activity, rather than a single narrow pathway, indicating a coupling between translation machinery and metabolic state. ","confidence":"Medium","size":26,"edges":49,"triangles":58,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0019878","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0006099","count":5},{"id":"GO:0006096","count":3}]},{"hash":"686696754165384082","title":"Protein quality control and stress response","description":"The dominant GO terms center on proteostasis-related processes: chaperone-mediated protein complex assembly, ubiquitin-dependent ERAD, SNARE and stress granule disassembly, and oxidative stress responses. These indicate a cluster focused on maintaining protein homeostasis and managing cellular stress, with the other terms (cell division, viral genome replication) likely reflecting contextual connections rather than defining the core function. ","confidence":"Medium","size":26,"edges":198,"triangles":677,"max_degree":24,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051301","count":13},{"id":"GO:0019079","count":13},{"id":"GO:0006272","count":11},{"id":"GO:1903007","count":11},{"id":"GO:0051131","count":11}]},{"hash":"1781784324513145294","title":"Muscle Development and Calcium Signaling","description":"The top GO terms cluster around muscle biology\u2014skeletal muscle fiber development and cardiac muscle hypertrophy\u2014together with regulation of postsynaptic cytosolic calcium, pointing to a shared theme of muscle development and Ca2+-dependent signaling. The presence of transcription regulation and complement activation terms appears more as peripheral annotations or noise rather than core to the cluster, so the primary signal is muscle-associated development and calcium signaling.","confidence":"Medium","size":26,"edges":7,"triangles":0,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045944","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0030901","count":3},{"id":"GO:0051343","count":3}]},{"hash":"1737243817038067966","title":"Neural GPCR signaling and synapse maintenance","description":"The top GO terms show strong enrichment for adenylate cyclase-activating GPCR signaling and roles in synapse assembly/maintenance and motor learning, indicating a neural signaling and synaptic plasticity focus. Some vascular-related terms appear but do not define a separate function; overall, the cluster coherently maps to neuronal signaling and synapse maintenance.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":16},{"id":"GO:0045777","count":16},{"id":"GO:0022900","count":16},{"id":"GO:0051965","count":15},{"id":"GO:0099558","count":14}]},{"hash":"1802925243123151359","title":"Steroid Hormone and Xenobiotic Metabolism","description":"Top GO terms point to hormone turnover and detoxification pathways (androgen metabolic process, vitamin D catabolic process, fatty acid omega-oxidation, xenobiotic catabolic process), plus stress- and ion-response terms. This suggests a coherent theme around metabolism of steroids/hormones and xenobiotics, with some auxiliary terms possibly reflecting secondary associations. ","confidence":"Medium","size":26,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":24},{"id":"GO:0035865","count":24},{"id":"GO:0010430","count":24},{"id":"GO:0060736","count":24},{"id":"GO:0071603","count":24}]},{"hash":"861269278984459049","title":"Integrin-Mediated Adhesion and Migration Signaling","description":"This cluster is dominated by GO terms related to cell-matrix and cell-cell adhesion, heterotypic adhesion, and integrin-mediated signaling, plus associated processes like extravasation and migration. The strongest cohesive theme is adhesion and signaling that drive cell movement and interactions with the extracellular matrix, with a few outliers (redox, PHB biosynthesis) that are less concordant.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0007161","count":5},{"id":"GO:0031104","count":4},{"id":"GO:0007229","count":4},{"id":"GO:0034113","count":4}]},{"hash":"1695507774991959003","title":"Ribosome Biogenesis and Translation","description":"The cluster is dominated by ribosome-related processes, including ribosome biogenesis, large subunit biogenesis, translation, and maturation of LSU-rRNA, indicating proteins functioning in ribosome assembly and protein synthesis; secondary signals like TORC1 signaling, cell division, and mRNA transport may reflect coordination of ribosome production with growth and gene expression, while antibiotic response and GTPase regulation likely reflect regulatory layers around ribosome function.","confidence":"High","size":26,"edges":19,"triangles":1,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":9},{"id":"GO:0042273","count":7},{"id":"GO:0006412","count":6},{"id":"GO:0046677","count":6},{"id":"GO:0051301","count":5}]},{"hash":"10002315959527522","title":"Unknown","description":"The top terms span meiotic cell cycle, DNA repair and replication, mitochondrial repair via homologous recombination, translation and translational initiation, EMT, inflammatory signaling, and deglycosylation. This broad mix does not converge on a single coherent biological function or pathway for the cluster, making a precise, representative label difficult.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0051321","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0050774","count":3},{"id":"GO:0050729","count":3},{"id":"GO:0006281","count":3}]},{"hash":"1692979909468490883","title":"Adhesion and immune activation in tissue morphogenesis","description":"The cluster\u2019s top GO terms emphasize cell adhesion molecule production and leukocyte/platelet interactions (positive regulation of platelet activation, leukocyte tethering or rolling), along with phagocytosis recognition and response to fungal origin, indicating adhesion-driven immune signaling. Simultaneously, developmental morphogenesis terms (cartilage condensation, mesonephric duct and tubule morphogenesis) suggest tissue development contexts where these adhesion and immune processes may be coordinated. This combination supports a label focused on adhesion-associated immune activation within tissue morphogenesis.","confidence":"Medium","size":26,"edges":42,"triangles":30,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":24},{"id":"GO:0060355","count":24},{"id":"GO:0006910","count":24},{"id":"GO:0072177","count":24},{"id":"GO:0072287","count":24}]},{"hash":"1546040558192375448","title":"ECM Remodeling and Complement Activation","description":"This cluster prominently links extracellular matrix-related processes (collagen catabolic process, cell adhesion, proteolysis, proteoglycan biosynthesis) with innate immune activity (complement activation via classical and lectin pathways) and inflammatory mediators (leukotriene biosynthesis). Additional terms like glutathione metabolism and maltose transport appear peripheral, suggesting some annotation noise or broader functions. Overall, the proteins seem focused on extracellular matrix remodeling coupled to immune system engagement.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0030574","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0006751","count":1}]},{"hash":"1266205192390437264","title":"Coagulation and Complement Activation Cluster","description":"This cluster is dominated by GO terms related to blood coagulation (blood coagulation; Factor XII activation) and complement activation (complement activation, classical pathway), with additional signals for leukocyte recruitment (positive regulation of leukocyte tethering or rolling). While transcription regulation and development terms appear among the top terms, the strongest and most frequent annotations point to coagulation and innate immune processes, suggesting a cohesive theme around coagulation-immune interplay with some broader regulatory roles.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035264","count":9},{"id":"GO:0006958","count":9},{"id":"GO:0045944","count":9},{"id":"GO:0007596","count":9},{"id":"GO:0000122","count":9}]},{"hash":"460019892217373164","title":"Ubiquitin-Dependent Proteolysis","description":"The proteins in this cluster are strongly enriched for ubiquitin- and proteasome-related processes (e.g., ubiquitin-dependent protein catabolic process, polyubiquitination, K48-linked ubiquitination, SCF-dependent proteasomal degradation) and autoubiquitination, with additional signals pointing to ubiquitin signaling and regulation of pathways such as JNK and NF-\u03baB. This points to a cohesive set of ubiquitin ligases, adaptors, and proteasome components driving proteolysis and related signaling modulation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0000209","count":9},{"id":"GO:0070936","count":8},{"id":"GO:0031146","count":8},{"id":"GO:0051865","count":7}]},{"hash":"2207097345544502542","title":"RNA processing and translation initiation","description":"This cluster is dominated by RNA processing and translation initiation terms: multiple entries for mRNA splicing via spliceosome (GO:0000398, GO:0002188, GO:0006376), mRNA processing-related polyadenylation (GO:0006378), and translation initiation factors including translation reinitiation and preinitiation complex formation (GO:0002188, GO:0001731). Together these suggest a functional module comprising splicing/processing components and translation initiation machinery, potentially coordinating mRNA maturation with the start of translation. A few terms indicate broader stress responses (response to nutrient, response to antibiotic) but are less central to the core theme.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":7},{"id":"GO:0001731","count":7},{"id":"GO:0007584","count":6},{"id":"GO:0006378","count":6},{"id":"GO:0045292","count":6}]},{"hash":"590411194410621824","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0006349","count":3},{"id":"GO:0043984","count":3},{"id":"GO:0016575","count":3}]},{"hash":"440665966349889764","title":"Sleep and Circadian Neural Signaling","description":"This cluster is enriched for GO terms related to neural activity and circadian rhythms: regulation of voltage-gated potassium channels, regulation of acetylcholine-gated channels, sleep and rhythmic processes, and regulation of synaptic transmission (cholinergic). A few terms about cuticle development or tube diameter appear incidental; the dominant theme ties neural signaling to sleep/circadian regulation.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903818","count":3},{"id":"GO:0045187","count":3},{"id":"GO:1903049","count":3},{"id":"GO:0035158","count":3},{"id":"GO:0030431","count":3}]},{"hash":"376328451166912441","title":"Embryonic development and morphogenesis","description":"The top GO terms cluster around embryonic development, tissue and organ morphogenesis (cartilage, palate, placenta, endocrine system), left-right patterning, and EMT in heart development, indicating a coherent focus on early development and tissue formation. A few terms about ribosomal export and DNA replication initiation may reflect proliferative states in development, but the dominant theme is embryonic development and morphogenesis.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0003323","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060972","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0035270","count":6}]},{"hash":"2161747969863264700","title":"Sphingolipid metabolism and glycerophospholipid biosynthesis","description":"The GO terms show a clear tilt toward sphingolipid biology, with sphingosine and sphinganine-1-phosphate metabolic processes enriched, alongside related phospholipid metabolism such as phospholipid dephosphorylation and phosphatidylglycerol biosynthesis. This suggests a cohesive cluster centered on lipid metabolism, particularly sphingolipids and glycerophospholipids. Some other terms (glucose-6-phosphate transport and cellular oxidant detoxification) may reflect broader metabolic context, and a few obsolete GO terms likely reflect annotation artifacts. Overall, the lipid-centric pattern provides a coherent cluster label.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":7},{"id":"GO:0046839","count":4},{"id":"GO:0006668","count":4},{"id":"GO:0006670","count":4},{"id":"GO:0035233","count":4}]},{"hash":"520107351973415512","title":"Unknown","description":"The top GO terms cover fatty acid biosynthesis, growth, retina development, transport, and various biosynthetic and immune processes, with no single cohesive function tying all terms together. The functions appear too heterogeneous to define a clear, representative cluster label, so I cannot assign a confident, specific name.","confidence":"","size":25,"edges":56,"triangles":50,"max_degree":22,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006633","count":10},{"id":"GO:0035264","count":8},{"id":"GO:0060041","count":7},{"id":"GO:0031460","count":6},{"id":"GO:0050830","count":6}]},{"hash":"1571686683407294583","title":"Metal-Ion Detoxification and Oxidative Stress Response","description":"This cluster is enriched for cellular oxidant detoxification and detoxification of nitrogen compounds, along with a strong signal for manganese ion response, which points to a core role in handling oxidative and metal-related stress. Additional terms related to signaling regulation (ERK cascade) and various cellular responses (response to amino acids, cell-matrix adhesion) suggest the proteins also participate in stress signaling and adaptive responses. The combination of detoxification and metal/ion\u2013related pathways, with supporting signaling terms, supports a cohesive theme around detoxification and metal-ion\u2013driven stress responses.","confidence":"Medium","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":23},{"id":"GO:2000255","count":21},{"id":"GO:0070458","count":20},{"id":"GO:0070373","count":20},{"id":"GO:1905804","count":20}]},{"hash":"843833358603941799","title":"Larval chitin-based cuticle development","description":"The strongest signal in this cluster is GO:0008363, larval chitin-based cuticle development, represented by 17 of 25 proteins, indicating a coherent role in cuticle formation during larval stages. Other GO terms appear less cohesive (some obsolete or regulatory), but the dominant theme clearly points to chitinous cuticle biosynthesis/assembly.","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":17},{"id":"GO:0030511","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0043524","count":1}]},{"hash":"1729970744892799102","title":"Translation initiation and mRNA processing","description":"This cluster is enriched for terms tied to translation initiation and mRNA processing/regulation (eIF4F complex assembly, preinitiation complex formation, regulation of translational initiation, mRNA stabilization, splicing recognition, and polyadenylation), indicating a core group of proteins involved in initiating translation and regulating mRNA fate, with some stress-responsive elements.","confidence":"High","size":25,"edges":296,"triangles":2210,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0097010","count":1},{"id":"GO:0010610","count":1},{"id":"GO:0006378","count":1},{"id":"GO:0001731","count":1},{"id":"GO:0006446","count":1}]},{"hash":"2179695183733020348","title":"Developmental morphogenesis and patterning","description":"This cluster is dominated by terms tied to tissue morphogenesis and developmental signaling: skin and eye morphogenesis, collagen fibril organization, chitin-based cuticle development, maternal axis specification, and Wnt signaling. While there are a couple of immune-related terms present, the prevailing pattern points to development and patterning processes in embryos and tissues, justifying this label.","confidence":"Medium","size":25,"edges":17,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0043589","count":3},{"id":"GO:0048593","count":3},{"id":"GO:0051965","count":3}]},{"hash":"769599662898388881","title":"Organogenesis and developmental gene regulation","description":"This cluster is dominated by GO terms tied to development of tissues and organs (neural tube closure, forebrain development, skeletal system development, multicellular organism development) and by processes related to gene expression and cell proliferation (DNA-templated transcription, mitotic cell cycle). These collectively point to developmental programs governed by transcriptional control, with some auxiliary stress or defense responses present as broader cellular context. Hence, the label emphasizes organogenesis and regulation of developmental gene expression.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001403","count":6},{"id":"GO:0001843","count":6},{"id":"GO:0030900","count":5},{"id":"GO:0001501","count":5},{"id":"GO:0050830","count":5}]},{"hash":"2213728575678604490","title":"Neural development and synaptic localization","description":"The cluster shows a clear emphasis on nervous system development and synaptic organization, with terms like motor neuron axon guidance, protein localization to synapse, and regulation of synaptic plasticity. Actin cytoskeleton remodeling and transcriptional regulation further support mechanisms underlying neurite outgrowth, synapse formation, and NMJ-like processes. The presence of visual perception and skeletal muscle development terms suggests broader neuronal or neuromuscular context, but the dominant theme remains neural development and synaptic targeting.","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007601","count":7},{"id":"GO:0007098","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0031532","count":4}]},{"hash":"1575669236187449547","title":"Nematode reproduction and embryogenesis","description":"The terms cluster around fertilization control (prevention of polyspermy, reduced binding of sperm to zona pellucida) and early development (maternal axis specification, embryonic morphogenesis), with nematode-specific features like molting/cuticle and pharyngeal pumping, suggesting a cohesive module of reproductive and embryonic processes in nematodes. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060468","count":4},{"id":"GO:0048632","count":4},{"id":"GO:0007313","count":4},{"id":"GO:0006508","count":4},{"id":"GO:0018996","count":4}]},{"hash":"802667200790879276","title":"Neural synapse development and regulation","description":"Many top terms point to neural and synaptic biology\u2014retina development, excitatory synapse assembly, postsynaptic potential regulation, and vesicle clustering/endocytosis\u2014indicating neural connectivity and synaptic function as the cluster's core theme. A few terms reflect broader transcription, xenobiotic response, and bone development, but they are less central.","confidence":"Medium","size":25,"edges":285,"triangles":1990,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":11},{"id":"GO:0006366","count":9},{"id":"GO:0002076","count":9},{"id":"GO:0002087","count":9},{"id":"GO:0090394","count":8}]},{"hash":"458137222490294720","title":"Neural development and sensory signaling","description":"This cluster\u2019s top GO terms span developmental processes (palate/mesoderm development and pancreatic B-cell development) alongside neural and sensory-related functions (taste aversion, long-term potentiation, GPCR signaling, prostaglandin response). Inflammatory and xenobiotic response terms also appear, suggesting broader signaling roles, but the mix still points to developmental signaling with neural/sensory modulation rather than a single cohesive pathway. Thus, a label centered on neural development and sensory signaling best captures the shared themes. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":4},{"id":"GO:0006954","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0071380","count":2}]},{"hash":"636644384317875848","title":"Tissue development and proliferative signaling","description":"The strongest signals are in tissue development (retina and skin) and cell proliferation, including positive regulation of population proliferation. This points to a theme of developmental growth and differentiation across multiple tissues. There are also players in signaling (GTPase activity) and protein assembly (homooligomerization) that support developmental processes. A few terms relate to environmental response (temperature stimulus, diet-induced thermogenesis, pain), which may reflect broader stress-response context rather than core function of the cluster.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008283","count":12},{"id":"GO:0060041","count":12},{"id":"GO:0043547","count":12},{"id":"GO:0071502","count":10},{"id":"GO:0019233","count":10}]},{"hash":"71175109411585329","title":"Ribosome Biogenesis and Translation","description":"The cluster is dominated by GO terms related to ribosome biogenesis (large and small subunits), rRNA maturation, ribosomal subunit export from the nucleus, formation of the translation preinitiation complex, and overall translation. A single outlier term for phosphatidylcholine biosynthesis is present but does not override the clear ribosome/protein synthesis theme.","confidence":"High","size":25,"edges":297,"triangles":2232,"max_degree":24,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":6},{"id":"GO:0000056","count":5},{"id":"GO:0000466","count":5},{"id":"GO:0000463","count":5},{"id":"GO:0006406","count":4}]},{"hash":"119063975477248465","title":"Unknown","description":"The terms include neural differentiation, skin development, immune complement activation, protein complex formation, signaling, and sensory pain detection, which do not converge on a single clear function. Without a cohesive theme, a specific label is not justifiable.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":3},{"id":"GO:0010745","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0051260","count":3}]},{"hash":"1098084642483601478","title":"Developmental signaling and transcriptional regulation","description":"The top GO terms cluster around transcriptional control (DNA-templated transcription) and multiple signaling pathways (Wnt, Hippo) with development/differentiation processes (nervous system development, keratinocyte differentiation) as well as related events like apoptosis, chemotaxis, and cell cycle, suggesting a theme of signaling coordinating transcriptional programs to drive development and cell fate across diverse cell types.","confidence":"Medium","size":25,"edges":52,"triangles":45,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":16},{"id":"GO:0050852","count":15},{"id":"GO:0090263","count":15},{"id":"GO:0006915","count":14},{"id":"GO:0006935","count":14}]},{"hash":"1708827571003730238","title":"Neural development and connectivity","description":"This cluster is dominated by neural development and connectivity terms: motor neuron axon guidance, cerebellar Purkinje cell differentiation, exocytosis, cell-cell junction organization, receptor clustering, and related signaling processes (growth hormone receptor signaling). There is one gonad development term, but the prevailing pattern points to neural development and intercellular communication.","confidence":"Medium","size":25,"edges":11,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":9},{"id":"GO:0060396","count":8},{"id":"GO:0008045","count":8},{"id":"GO:0007160","count":8},{"id":"GO:0043113","count":8}]},{"hash":"1408158558058096065","title":"Mitotic progression and kinetochore localization","description":"This cluster is dominated by mitosis-related terms: G1/S and G2/M transitions, re-entry into mitosis, positive regulation of spindle pole separation, and protein localization to the kinetochore, with H3S10 phosphorylation tied to chromosome condensation. A transcriptional term appears but likely reflects general cell-cycle\u2013linked transcription; insulin signaling regulation hints at proliferative context rather than a distinct pathway. Overall, the core theme is cell-cycle progression and kinetochore dynamics.","confidence":"High","size":25,"edges":133,"triangles":395,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000086","count":19},{"id":"GO:0000320","count":19},{"id":"GO:0000082","count":19},{"id":"GO:0006351","count":19},{"id":"GO:0033598","count":19}]},{"hash":"172410320272258785","title":"Acute inflammatory response and coagulation","description":"The top GO terms point to innate immune activation (response to lipopolysaccharide, acute-phase response, leukocyte tethering/rolling) and coagulation (Factor XII activation). While a couple terms (growth, transcription regulation) are broader, the dominant signal is inflammation with coagulation interplay, suggesting a cluster involved in acute inflammatory response and coagulation pathways.","confidence":"Medium","size":25,"edges":123,"triangles":243,"max_degree":22,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0035264","count":6},{"id":"GO:0032496","count":6},{"id":"GO:0045944","count":6},{"id":"GO:0006953","count":6},{"id":"GO:0007596","count":6}]},{"hash":"2103914854112504422","title":"Muscle Stretch Signaling and Regeneration with Angiogenesis","description":"The cluster centers on muscle-related signaling and regeneration, highlighted by muscle stretch response, calcium release, and skeletal muscle regeneration, with accompanying vascular remodeling via angiogenesis and related pathways such as Wnt signaling. Some terms appear incidental (NF-kappaB regulation, telomeric localization, ADP-ribosylation), but the dominant theme is muscle signaling linked to regeneration and blood vessel growth.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":4},{"id":"GO:0016055","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0051209","count":3},{"id":"GO:0035994","count":3}]},{"hash":"1292033544501317115","title":"Vascular remodeling and coagulation","description":"Top terms center on angiogenesis, ECM disassembly, and coagulation/fibrinolysis, with supporting roles for Wnt signaling and leukocyte recruitment. The cluster appears to group proteins involved in vascular tissue remodeling and hemostasis, rather than a single enzymatic pathway, suggesting a cohesive theme of blood vessel formation and extracellular matrix turnover with immune context.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":7},{"id":"GO:0016055","count":6},{"id":"GO:0042730","count":6},{"id":"GO:0007596","count":6},{"id":"GO:0045766","count":5}]},{"hash":"1828458961243355819","title":"Unknown","description":"The top GO terms are diverse (cell division, ribosomal biogenesis, spinal cord and neuron development, ubiquitination, cadmium response, microtubule movement), and there are no connecting edges among proteins, so a single cohesive function isn\u2019t evident. This cluster appears to sample multiple, unrelated processes rather than a unified pathway.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0042273","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0050731","count":2},{"id":"GO:0070979","count":2}]},{"hash":"611140174163522413","title":"Unknown","description":"The top GO terms are very diverse (RNA capping and methylation; menaquinone biosynthesis; nicotinate nucleotide salvage; xenobiotic and epinephrine responses; proteolysis; rDNA heterochromatin formation; phospholipid metabolism), suggesting no single coherent function unites the cluster. A concise, representative label is not feasible.","confidence":"","size":25,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":4},{"id":"GO:0006370","count":3},{"id":"GO:0036265","count":3},{"id":"GO:0019358","count":3},{"id":"GO:0042493","count":3}]},{"hash":"815869592389926046","title":"Ubiquitin-Proteasome System and Metal Stress Response","description":"The cluster is strongly tied to ubiquitin tagging and proteasome-mediated degradation (ubiquitin-dependent protein catabolic process, protein polyubiquitination, SCF-dependent proteasomal ubiquitin-dependent catabolic process), with supportive signals toward cell-cycle related regulation. The presence of GO terms for cellular responses to cadmium, methylmercury, and arsenic suggests these proteins participate in metal-induced stress responses, reinforcing a cohesive theme around proteostasis under stress.","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0030174","count":8},{"id":"GO:1903378","count":8},{"id":"GO:0000083","count":8},{"id":"GO:0071406","count":8}]},{"hash":"186487960153770114","title":"Blood coagulation and complement activation","description":"The dominant signals are blood coagulation, complement activation (classical and lectin), plasminogen activation, and fibrinolysis, with related processes like angiogenesis and biomineral tissue development, suggesting a coagulation\u2013immune remodeling module.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0006958","count":8},{"id":"GO:0007596","count":8},{"id":"GO:0007586","count":6},{"id":"GO:0045766","count":6},{"id":"GO:0031214","count":6}]},{"hash":"294838133419414445","title":"Coagulation and Complement Components","description":"The top GO terms are dominated by complement activation (classical pathway) and blood coagulation, with Factor XII activation and leukocyte tethering/rolling, suggesting a set of proteins involved in coagulation and innate immune interactions. There are additional terms about development and transcription regulation that appear less central to the cluster, likely reflecting broader annotation rather than a unifying function. Overall, the core connection appears to be coagulation and complement-related proteins.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":7},{"id":"GO:0030901","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0007596","count":6},{"id":"GO:0014068","count":5}]},{"hash":"1333375565289356361","title":"Epithelial morphogenesis and ectodermal development","description":"The GO terms are dominated by epithelial-related processes (desmosome organization, skin barrier establishment, epithelial morphogenesis) and ectoderm-derived organ development (eye, cochlea, salivary gland, epidermis). This points to a shared function in epithelial tissue formation and ectodermal organogenesis, with some general morphogenetic roles across tissues.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904667","count":2},{"id":"GO:0002934","count":2},{"id":"GO:0061436","count":2},{"id":"GO:0090132","count":2},{"id":"GO:0043010","count":2}]},{"hash":"17352601228217742","title":"Unknown","description":"The listed GO terms are highly diverse (DNA integration; skeletal muscle development; dendritic cell and pro-T cell differentiation; ubiquitination; phototropism; plant- and animal-specific processes), and with no edges or shared functional term among the proteins, there is no coherent theme tying the cluster together. Therefore the cluster is best labeled Unknown.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:1900477","count":3},{"id":"GO:0007519","count":3},{"id":"GO:1990390","count":3},{"id":"GO:0045497","count":3}]},{"hash":"589910010532406509","title":"Neuronal axon guidance and synapse development","description":"These terms cluster around neuronal development, especially axon guidance, synapse formation and plasticity, and associated signaling and mRNA transport mechanisms, with ventral spinal cord development reinforcing a spinal neuron development theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0051028","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0007200","count":3}]},{"hash":"1507450790795198217","title":"Neural signaling and potassium homeostasis","description":"The cluster includes neuronal signaling terms (sensory perception of pain, dopaminergic synaptic transmission, visual learning) and potassium ion transport/homeostasis, suggesting roles in neuronal excitability and signaling. ERK1/2 cascade regulation supports broader signaling activity, with some development-related terms (heart development, multicellular organism development) indicating additional context beyond neurons.","confidence":"Medium","size":24,"edges":110,"triangles":200,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0019233","count":8},{"id":"GO:0030007","count":8},{"id":"GO:0008542","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0010759","count":7}]},{"hash":"2110965203692182703","title":"Larval chitin-based cuticle development","description":"The top GO term is GO:0008363, larval chitin-based cuticle development, with 24 proteins in this cluster. This strong, uniform annotation indicates that the proteins collectively participate in the formation and maturation of the larval cuticle composed of chitin, pointing to a cohesive developmental module for exoskeletal structure in larvae. The full overlap of proteins with the term supports a high-confidence, representative label.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":24}]},{"hash":"786972287740545926","title":"RNA Polymerase III Transcription Machinery","description":"The strongest signals are about transcription regulation by RNA polymerase III and tRNA transcription (regulation of Pol III transcription, initiation at Pol III promoters, and tRNA transcription by Pol III), suggesting this cluster is centered on the Pol III transcription machinery. A few immune-related terms appear, but they are secondary to the Pol III transcription theme.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032728","count":3},{"id":"GO:2001200","count":2},{"id":"GO:0006407","count":2},{"id":"GO:0050718","count":2},{"id":"GO:0061303","count":2}]},{"hash":"1133703633693481784","title":"Potassium Transport and Membrane Potential","description":"This cluster centers on potassium handling and maintaining membrane potential, as shown by GO terms for potassium ion transport, intracellular potassium homeostasis, stabilization and repolarization of membrane potential, and regulation of resting membrane potential. Additional terms related to excitability and sensory perception (touch, pain) plus cAMP signaling suggest involvement in excitable cell signaling, all tying back to potassium-driven membrane dynamics.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":17},{"id":"GO:0050976","count":17},{"id":"GO:0098914","count":17},{"id":"GO:0060075","count":15},{"id":"GO:0030007","count":15}]},{"hash":"2048230946190435833","title":"Fungal Defense via Complement and Coagulation","description":"The cluster centers on antifungal defense and inflammatory signaling, with terms for defense response to fungus, classical complement activation, neutrophil-mediated killing, and Factor XII\u2013driven coagulation, suggesting a cohesive innate-immune module linked to coagulation; digestion and Wnt/elastin terms are less connected.","confidence":"Medium","size":24,"edges":51,"triangles":26,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0050832","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0007596","count":6},{"id":"GO:0042127","count":5},{"id":"GO:1903238","count":5}]},{"hash":"1763396350717124882","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051321","count":3},{"id":"GO:0000472","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0000154","count":2},{"id":"GO:0070481","count":2}]},{"hash":"1514854368341689995","title":"Larval cuticle development and actin dynamics","description":"This cluster is dominated by larval chitin-based cuticle development (GO:0008363) with high representation (13), suggesting a primary role in insect cuticle formation. The presence of actin-related terms (actin filament polymerization, actin cytoskeleton organization) and centrosome localization points to coordinated cytoskeletal remodeling during development. Signaling and immune-related terms (TGF-beta response, innate immune response) imply broader regulatory networks that connect development, signaling, and defense. Overall, the core theme appears to be developmentally coordinated cuticle formation with cytoskeletal dynamics.","confidence":"High","size":24,"edges":119,"triangles":291,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":13},{"id":"GO:0030433","count":3},{"id":"GO:0051660","count":2},{"id":"GO:0030041","count":2},{"id":"GO:0060292","count":2}]},{"hash":"2285002127073067016","title":"Cross-tissue Development and Differentiation","description":"The top GO terms cover diverse developmental and differentiation processes across many tissues and species (larval cuticle, nervous system, heart structures, lens, reproductive organs, uterus, placental fusion, etc.). With no shared interaction pattern (Edges: 0), the proteins appear related to general developmental roles rather than a single pathway, so a cross-tissue development theme is the most representative and concise label.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0050853","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0045647","count":2}]},{"hash":"1552732717116006708","title":"Larval chitin-based cuticle development","description":"Most frequent GO term in the cluster is larval chitin-based cuticle development (GO:0008363) with 7 proteins, pointing to a predominant role in insect cuticle formation. There are a few RNA interference and ncRNA-related terms and other diverse annotations present at low frequency, which introduces some noise but does not outweigh the dominant signal. Therefore the label reflects the main functional theme, with moderate confidence due to ancillary terms that may not be core to the cluster\u2019s primary function.","confidence":"Medium","size":24,"edges":10,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":7},{"id":"GO:0002023","count":1},{"id":"GO:0009749","count":1},{"id":"GO:0031053","count":1},{"id":"GO:0050829","count":1}]},{"hash":"2115679262447448436","title":"Diverse Stimulus Response and Morphogenesis","description":"The top GO terms point to a wide range of responses to environmental cues (nutrients, auxin-like signals, lipoprotein stimuli) and several developmental or morphogenesis processes (nodulation, sorocarp morphogenesis, pigment biosynthesis). There isn\u2019t a single, tight function tying all proteins together; rather, the cluster seems enriched for broad stimulus responses combined with development-related processes, suggesting a collection of proteins involved in signaling and morphological adaptation across diverse contexts.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007584","count":14},{"id":"GO:0009432","count":14},{"id":"GO:0006727","count":13},{"id":"GO:0031288","count":13},{"id":"GO:0055099","count":13}]},{"hash":"1556486355569038676","title":"Regulated phosphorylation and cytoskeleton control","description":"The top GO terms center on signaling regulation (peptidyl-tyrosine phosphorylation, GTPase activity, protein autophosphorylation) and cytoskeletal modulation (barbed-end actin filament capping) with some adhesion-related terms, plus a few developmental/reproductive processes. This suggests a cohesive theme around controlling signal transduction and the cytoskeleton, which underlies both adhesion and developmental signaling. Thus, a label focusing on regulation of phosphorylation signaling and cytoskeletal dynamics best captures the cluster\u2019s shared function.","confidence":"Medium","size":24,"edges":13,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":3},{"id":"GO:0060468","count":2},{"id":"GO:2000360","count":2},{"id":"GO:0030157","count":2},{"id":"GO:0008363","count":2}]},{"hash":"209922950524692524","title":"Embryonic organogenesis and neural development","description":"This cluster contains GO terms spanning multiple organ systems and developmental processes (heart, skeletal muscle, midbrain, spleen, cranial skeleton morphogenesis, neuron migration, organ induction), indicating a broad role in embryonic organ development. The inclusion of translation and transcription regulation terms suggests these proteins coordinate gene expression during these developmental programs, making the theme cohesive across tissues. ","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0006412","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0007519","count":4},{"id":"GO:0030901","count":4}]},{"hash":"1275344268623413358","title":"Steroid hormone metabolism and pigment biosynthesis","description":"The top GO terms cluster around steroid-related pathways (androgen metabolism/catabolism, C21-steroid hormone metabolism, glucocorticoid biosynthesis) and pigment-related processes (melanin biosynthesis, retinal metabolism), with BH4 biosynthesis and fatty acid elongation also represented. This suggests a cohesive module focused on steroid hormone biosynthesis/metabolism with associated pigment and retinal metabolic activities. ","confidence":"High","size":24,"edges":211,"triangles":987,"max_degree":23,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008209","count":23},{"id":"GO:0006710","count":23},{"id":"GO:0006729","count":23},{"id":"GO:0042574","count":23},{"id":"GO:0006704","count":23}]},{"hash":"65354323590082048","title":"Unknown","description":"The GO terms span plant hormone signaling (auxin pathway), neural and nervous system processes (GABA transport, myelin assembly, axon regeneration, vocalization), immune-related signaling (platelet activation), and general transport (dipeptide/oligopeptide transport) as well as nitrate response, with no single coherent function linking all proteins. This lack of a unifying theme leads me to label the cluster Unknown.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009734","count":3},{"id":"GO:0015812","count":2},{"id":"GO:0032288","count":2},{"id":"GO:0043507","count":2},{"id":"GO:0010572","count":2}]},{"hash":"1273874112192422524","title":"Glycinergic and Monoamine Neurotransmitter Transporters","description":"Dominant terms point to transporter proteins handling glycine and other neurotransmitters, with glycinergic synaptic transmission, glycine import, and uptake of dopamine and serotonin being central. Additional terms for taurine and proline transport and brain-associated development signals (thalamus development, perineurial glial growth) support a brain-context transporter cluster. Overall, this cluster appears to be membrane transporters mediating neurotransmitter and amino acid uptake, especially glycine, in neural tissue.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021794","count":7},{"id":"GO:0060092","count":7},{"id":"GO:0015734","count":7},{"id":"GO:1903346","count":7},{"id":"GO:0036233","count":7}]},{"hash":"1068040281208067146","title":"Vascular NO signaling and oxidative stress response","description":"The prominent GO terms center on regulation of nitric oxide biosynthesis, oxidative stress detoxification, blood pressure regulation, angiogenesis, and coagulation, with related remodeling signals (TGF-\u03b2 production and mechanical stimulus response), suggesting a cohesive vascular/endothelial signaling module focused on NO signaling and redox balance.","confidence":"High","size":24,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045429","count":5},{"id":"GO:0042744","count":4},{"id":"GO:0050873","count":4},{"id":"GO:0008217","count":4},{"id":"GO:0098869","count":4}]},{"hash":"257255888657837154","title":"Notch-driven heart and endothelial development","description":"Based on the Top Terms, the cluster is enriched for Notch signaling regulation, heart morphogenesis (cardiac right atrium, secondary heart field proliferation), and venous endothelial differentiation, with supporting themes of cell migration and actin cytoskeleton assembly. These collectively point to a set of proteins involved in cardiovascular development governed by Notch signaling, with cytoskeletal and cell-organization processes supporting morphogenesis and endothelial differentiation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045747","count":3},{"id":"GO:0030913","count":3},{"id":"GO:0061462","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0060843","count":3}]},{"hash":"1749612237083645118","title":"Inflammation and stress response regulators","description":"The top GO terms center on inflammatory response, hypoxic/stress signaling (cellular response to hypoxia, response to glucocorticoid), and oxidative stress (hydrogen peroxide biosynthetic process), along with apoptosis regulation. Together these suggest a theme of immune and stress signaling rather than a single metabolic or structural function, though a few developmental terms appear as broader annotations. This supports labeling the cluster as inflammation- and stress-related regulators, with some annotation noise or context-specific roles. ","confidence":"Medium","size":24,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0070542","count":2},{"id":"GO:0008365","count":2},{"id":"GO:0071456","count":2}]},{"hash":"1196254075435359129","title":"Platelet activation and vascular regulation","description":"Enrichment centers on platelet activation, regulation of integrin activation, and negative regulation of fibrinolysis, all core to platelet-mediated vascular function. Additional signals related to insulin signaling and glucose response imply metabolic coordination with vascular processes. Some apoptosis-related terms appear, possibly reflecting broader cell signaling contexts, but the dominant theme is platelet-driven vascular regulation with metabolic links.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051918","count":5},{"id":"GO:0071333","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0010765","count":4},{"id":"GO:0008286","count":4}]},{"hash":"990319203527188590","title":"Neural development, synapse formation, and myelination","description":"This cluster centers on neural tissue development and connectivity, with GO terms for retina morphogenesis, motor neuron axon guidance, synapse assembly, and myelination, plus cell-cell adhesion. While there are immune and extracellular matrix-related terms (complement activation, basement membrane development), the dominant pattern ties to neural development and neural connectivity.","confidence":"High","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":8},{"id":"GO:0060042","count":7},{"id":"GO:0007157","count":7},{"id":"GO:0051965","count":7},{"id":"GO:0032836","count":6}]},{"hash":"483274553669361253","title":"Glutamatergic NMDA receptor\u2013mediated synaptic transmission","description":"The cluster is dominated by terms tied to excitatory glutamatergic signaling and NMDA receptor regulation (including NMDA receptor clustering and activity, and positive regulation of excitatory postsynaptic potential), pointing to a cohesive theme of glutamatergic synapses and excitatory transmission. Some terms related to pain or SA node action potential are present but not central to the core function.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":4},{"id":"GO:0051968","count":3},{"id":"GO:0016540","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0098907","count":3}]},{"hash":"235522642607635298","title":"Unknown","description":"The GO terms are spread across multiple, diverse developmental and regulatory processes (tooth, germ cell, ovarian follicle, skeletal muscle development; transcription regulation; ubiquitination; T cell differentiation), with no single cohesive function tying the cluster together. This makes a specific, representative label unlikely.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042487","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0008354","count":2},{"id":"GO:0001541","count":2},{"id":"GO:1900477","count":1}]},{"hash":"1996511835851700583","title":"Nutrient sensing and xenobiotic stress signaling","description":"This cluster\u2019s top terms cluster around responses to nutrients, xenobiotics, and antibiotics, along with TORC1 signaling and regulation of GTPase activity, pointing to a common theme of nutrient sensing and stress response pathways. Some terms (like ommochrome biosynthesis and sorocarp morphogenesis) are less clearly connected but may reflect broader developmental and pigment-related processes in the organism. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007584","count":5},{"id":"GO:0046677","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0038202","count":3},{"id":"GO:0043547","count":3}]},{"hash":"2275140715837456661","title":"Rho GTPase\u2013driven actin remodeling and junctions","description":"Top terms converge on Rho/small GTPase signaling and actin dynamics (actin cytoskeleton organization, filopodium assembly) plus junction-related processes (centrosome localization, bicellular tight junction assembly). This suggests a theme of cytoskeletal remodeling and cell\u2013cell junction regulation governed by Rho GTPases. Other terms point to broader tissue contexts but do not negate the core cytoskeletal signaling pattern.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0051660","count":4},{"id":"GO:0070830","count":4},{"id":"GO:0030036","count":4},{"id":"GO:0046847","count":4}]},{"hash":"364901283564359305","title":"Innate immune transcription regulators","description":"These proteins show strong enrichment for transcription regulation by RNA polymerase II (both negative and positive regulation), and several annotations point to innate immune responses (response to lipopolysaccharide, neutrophil activity, leukocyte tethering/rolling). This suggests a cohesive theme of transcriptional control in immune signaling. Some other terms (midbrain development, elastin catabolic process, Factor XII activation, digestion) are broader or less directly connected, possibly reflecting multifunctionality or annotation noise, but the core pattern supports the label.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0045944","count":9},{"id":"GO:0032496","count":8},{"id":"GO:0030901","count":8},{"id":"GO:0042127","count":7}]},{"hash":"414375849677333296","title":"Unknown","description":"The listed GO terms span both developmental processes (mesoderm and skeletal muscle development) and general cellular machinery (ribosome biogenesis/export, ER-Golgi transport, phosphorylation) with no clear single function linking them all. This lack of a cohesive theme suggests the cluster is Unknown.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900477","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0070262","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0007498","count":2}]},{"hash":"2200753275959270042","title":"Inflammation and eicosanoid biosynthesis","description":"Based on GO terms, the proteins are linked to acute and chronic inflammatory responses, response to cytokines and LPS, and to biosynthesis of prostaglandins and leukotrienes (lipid mediators). This points to a cluster of inflammation-driven signaling and lipid mediator production. Some terms like Leydig cell differentiation or obsolete terms are less central and do not override the main theme.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014070","count":1},{"id":"GO:0034097","count":1},{"id":"GO:0043085","count":1},{"id":"GO:0002544","count":1},{"id":"GO:0032496","count":1}]},{"hash":"1811091851603406007","title":"Unknown","description":"The Top Terms are a mix of reproduction (polyspermy prevention; regulation of sperm binding to zona pellucida), early development (maternal axis specification; embryonic morphogenesis), nematode- and invertebrate-specific processes (molting cycle and pharyngeal pumping), plus general processes (translation, proteolysis, lymph gland development). There is no clear, cohesive theme linking these proteins to a single function or pathway, suggesting the cluster is heterogeneous. ","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060468","count":3},{"id":"GO:0048632","count":3},{"id":"GO:0007313","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0018996","count":3}]},{"hash":"422264208011774454","title":"Redox Homeostasis and Oxidative Stress Response","description":"The cluster is enriched for oxidative-reduction and redox-related terms (cell redox homeostasis, response to oxidative stress, cellular oxidant detoxification) along with related metabolic processes and stress responses (starvation, glycerol metabolism, pseudohyphal growth, translation). This points to a cohesive theme of maintaining redox balance and defending against oxidative damage, with auxiliary links to metabolism and growth adaptation, justifying a label focused on redox biology and stress response.","confidence":"High","size":23,"edges":252,"triangles":1750,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0045454","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0042594","count":2},{"id":"GO:0030416","count":2}]},{"hash":"1695914618342781346","title":"Angiogenesis signaling and ECM proteoglycan biosynthesis","description":"Top GO terms are dominated by angiogenesis and its positive regulation, with the ERK1/ERK2 cascade indicating MAPK-driven angiogenic signaling. The accompanying proteoglycan biosynthesis terms (chondroitin sulfate, heparan sulfate) fit with ECM remodeling needed for angiogenesis. Other terms (cadmium transport, sodium homeostasis, photosynthesis, ATP synthesis) are less central and likely reflect broader cellular functions or annotation noise. Overall, the cluster centers on angiogenic signaling with ECM remodeling context.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0030206","count":3},{"id":"GO:0015015","count":3},{"id":"GO:0042773","count":2}]},{"hash":"1583415557927941410","title":"Dopamine and Adrenergic GPCR Signaling","description":"This cluster is dominated by GO terms for G protein-coupled receptor signaling, including activation of adenylate cyclase, adrenergic/dopaminergic pathways, GPCR internalization, and arrestin-mediated desensitization, as well as regulation of dopamine secretion and photoreceptor maintenance. Together these suggest a coherent GPCR signaling module centered on dopamine and adrenergic inputs, with a possible outlier term for electron transport chain that does not alter the overall theme.","confidence":"High","size":23,"edges":3,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007190","count":22},{"id":"GO:0010579","count":22},{"id":"GO:0045777","count":22},{"id":"GO:0022900","count":22},{"id":"GO:0031635","count":21}]},{"hash":"250874288309127068","title":"RNA Processing and Translation Initiation Regulation","description":"The top GO terms point to post-transcriptional RNA processing (splicing, splice site recognition, mRNA stability) and regulation of translation initiation (preinitiation complex formation and IF4F assembly), indicating a cohesive cluster of proteins involved in RNA maturation and control of protein synthesis.","confidence":"High","size":23,"edges":239,"triangles":1511,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":20},{"id":"GO:0031047","count":16},{"id":"GO:0048026","count":15},{"id":"GO:0006378","count":13},{"id":"GO:0097010","count":12}]},{"hash":"828009629974509057","title":"T cell activation and plasma cell differentiation","description":"These proteins cluster around adaptive immunity: terms include positive regulation of T cell activation via TCR-MHC interactions, regulation of T cell cytokine production, and plasma cell differentiation. Additional terms touch on viral response, cell\u2013cell adhesion, and metabolic adjustments (glucose/lipid processes), suggesting coordinated activation and differentiation of immune cells. ","confidence":"High","size":23,"edges":245,"triangles":1610,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":3},{"id":"GO:0098586","count":3},{"id":"GO:2001190","count":2},{"id":"GO:0002724","count":2},{"id":"GO:0002317","count":2}]},{"hash":"455269560182313130","title":"Chromatin regulation and transcription control","description":"The cluster's GO terms cluster around transcription regulation by RNA Pol II, chromatin remodeling, and heterochromatin formation, with telomere maintenance linked to chromatin state; this suggests a core theme of nuclear genome regulation, with a few peripheral signaling/development terms. Therefore the name reflects the central function, albeit with some outliers.","confidence":"Medium","size":23,"edges":45,"triangles":31,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0071353","count":3},{"id":"GO:0030466","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0043044","count":2}]},{"hash":"112259429265967974","title":"Neural-immune signaling and cytoskeletal dynamics","description":"This cluster centers on neural development and signaling (axonogenesis, synaptic plasticity, GPCR desensitization), immune cell signaling (T cell receptor, mast cell cytokine production), and apoptosis, with a thread of actin cytoskeleton remodeling. Together these terms suggest a shared theme of signaling cross-talk between neural and immune systems alongside cytoskeletal dynamics.","confidence":"Medium","size":23,"edges":150,"triangles":449,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031532","count":23},{"id":"GO:0007409","count":23},{"id":"GO:0010898","count":23},{"id":"GO:0032092","count":23},{"id":"GO:0050852","count":23}]},{"hash":"539702753028177805","title":"Ribosome Biogenesis and Translation","description":"The terms are dominated by ribosome assembly and function: maturation of SSU rRNA, small subunit biogenesis, cytoplasmic translation, overall translation, and tRNA modification. The inclusion of cell cycle and cell division terms aligns with growth and proliferation linked to ribosome production. A few outliers like conjugation with cellular fusion exist but do not override the central theme. This cluster most plausibly represents proteins involved in ribosome biogenesis and protein synthesis.","confidence":"High","size":23,"edges":249,"triangles":1690,"max_degree":22,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":14},{"id":"GO:0042254","count":12},{"id":"GO:0000462","count":7},{"id":"GO:0042274","count":6},{"id":"GO:0002181","count":5}]},{"hash":"253715787042771469","title":"Cerebellar synaptic plasticity and learning","description":"The cluster centers on cerebellar-related functions, including cerebellar granule cell differentiation and long-term synaptic depression, with links to intracellular signal transduction and learning-era processes such as medium-term memory and conditioned taste aversion. The presence of potassium and sodium ion transmembrane transport and rhythmic excitation suggests neuronal excitability underlying synaptic changes, supporting a theme of cerebellar-dependent plasticity and associated learning behavior.","confidence":"Medium","size":23,"edges":59,"triangles":29,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":6},{"id":"GO:0060292","count":5},{"id":"GO:0035556","count":5},{"id":"GO:0035176","count":5},{"id":"GO:0071805","count":5}]},{"hash":"890765212397554245","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":184,"triangles":762,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000472","count":8},{"id":"GO:0000480","count":8},{"id":"GO:0030433","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0042273","count":7}]},{"hash":"1018844033346529445","title":"Embryonic Organ Morphogenesis","description":"The top GO terms point to diverse embryonic tissue development and morphogenesis (heart, eye, hindlimb, placenta, habenula, prostate) along with DNA-templated transcription, indicating these proteins likely act as developmental regulators coordinating organ formation rather than a single tissue-specific function.","confidence":"High","size":23,"edges":3,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:2000288","count":7},{"id":"GO:0021986","count":7},{"id":"GO:0048048","count":7},{"id":"GO:0003148","count":7}]},{"hash":"793340008245690948","title":"Unknown","description":"The top GO terms are scattered across diverse biological themes: neuronal migration, platelet aggregation, hormone response, dephosphorylation, calcium and zinc ion transport, phospholipid dephosphorylation, and sialic acid biosynthesis, with several obsolete terms. There isn't a single cohesive function tying these proteins together, making a clear label difficult.","confidence":"","size":23,"edges":231,"triangles":1360,"max_degree":22,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0070527","count":7},{"id":"GO:0097477","count":7},{"id":"GO:0016311","count":6},{"id":"GO:0033574","count":6}]},{"hash":"18272241807180998","title":"Membrane transporters for ions and nutrients","description":"This cluster is dominated by transmembrane transport GO terms across a range of substrates (potassium ions, nitrite/nitrate, arabinose, sialic acid, vitamins), plus related processes like neurotransmitter loading into synaptic vesicles, indicating a cohesive theme of membrane transporters handling diverse solutes.","confidence":"High","size":23,"edges":15,"triangles":3,"max_degree":10,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0007605","count":5},{"id":"GO:0006004","count":4},{"id":"GO:0042891","count":4},{"id":"GO:0098700","count":4}]},{"hash":"2146848286322158043","title":"Developmental Regulation and Chromosome Cohesion","description":"This cluster mixes developmental processes (root, neural plate, limb morphogenesis, prostate gland epithelial proliferation) with nuclear/cell-cycle functions (centromeric centriole cohesion, NLS-dependent nuclear import, GTPase regulation) and apoptosis. The common thread appears to be regulatory proteins involved in development alongside key nuclear and chromosomal processes, suggesting a cohesive theme of development-linked control of cell division and chromatin dynamics.","confidence":"Medium","size":23,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0043547","count":8},{"id":"GO:0006607","count":6},{"id":"GO:0060769","count":5},{"id":"GO:1904793","count":5},{"id":"GO:0070602","count":5}]},{"hash":"2291391284627444920","title":"Development and Immune Differentiation","description":"The top GO terms span developmental processes (skeletal system development, lens fiber cell differentiation, multicellular organism development) and immune-related functions (antigen processing and presentation via MHC I, positive regulation of dendritic cell differentiation), with additional tissue-remodeling signals (collagen catabolic process, proteolysis). This suggests a broad theme around organism development coupled with immune system maturation/differentiation rather than a single specific pathway, hence the label Development and Immune Differentiation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:0006751","count":2},{"id":"GO:1901750","count":2},{"id":"GO:0006750","count":2},{"id":"GO:0030574","count":2}]},{"hash":"322573665879522163","title":"Inflammation-driven chemokine production and cell migration","description":"The cluster\u2019s top GO terms cluster around inflammatory response and chemokine production, along with cell migration and Rac signaling, suggesting a core function in immune signaling and cytoskeletal dynamics. Additional terms for ECM remodeling and carbohydrate metabolism hint at tissue remodeling accompanying inflammation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006032","count":3},{"id":"GO:0002532","count":3},{"id":"GO:0005975","count":3},{"id":"GO:0090197","count":3},{"id":"GO:0030574","count":2}]},{"hash":"1390703398941329349","title":"Transcription and translation regulators","description":"Based on the top GO terms, the proteins cluster around controlling gene expression at multiple levels: transcription regulation by RNA polymerase II (both positive and negative), assembly of the translation preinitiation complex and regulation of translational initiation, as well as mRNA stability and splicing aspects. The combination indicates a regulatory module coordinating expression at transcriptional and post-transcriptional/ translational stages, rather than a single pathway. The presence of heart development is a tissue annotation rather than a core function, so the main theme remains gene expression regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0097010","count":1},{"id":"GO:0010610","count":1}]},{"hash":"996641750708051631","title":"Nervous System Development and Synaptic Signaling","description":"The cluster is strongly enriched for neural development and synaptic function terms: axonogenesis, Schwann cell development, visual perception, excitatory postsynaptic potential, and long-term potentiation indicate neuron and synapse\u2013related roles. The presence of mitotic cell cycle and apoptotic regulation terms can reflect developmental cell turnover, while the abscisic acid\u2013activated pathway likely represents cross-domain annotation noise. Overall, the dominant theme points to nervous system development and synaptic activity.","confidence":"High","size":23,"edges":74,"triangles":47,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007409","count":22},{"id":"GO:0014044","count":22},{"id":"GO:0009738","count":22},{"id":"GO:0060079","count":22},{"id":"GO:0007601","count":22}]},{"hash":"559484760586175408","title":"Unknown","description":"Top GO terms are scattered across transcription regulation, development, immune/coagulation, reproduction, and behavior, with no single cohesive function tying the cluster together. This makes it hard to assign a confident, representative label.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0030901","count":9},{"id":"GO:0045944","count":7},{"id":"GO:0016055","count":6},{"id":"GO:0006958","count":6}]},{"hash":"1887896728141831413","title":"Membrane transporters and epithelial polarity","description":"The cluster is dominated by GO terms for various transmembrane transport processes (nitrate, nitrite, potassium, phosphate, sialic acid, galactose, sodium-independent organic anions) and a term for neurotransmitter loading into synaptic vesicles, plus a term related to establishing epithelial cell polarity. This pattern suggests a group of proteins involved in membrane transport and vesicle trafficking with roles in polarized cells, rather than a single enzymatic pathway. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":4},{"id":"GO:0006397","count":4},{"id":"GO:0015706","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0015739","count":3}]},{"hash":"2280194622677613980","title":"Hemostasis and Innate Immunity","description":"The cluster centers on coagulation/fibrinolysis (blood coagulation, fibrinolysis, Factor XII activation) and leukocyte dynamics (positive regulation of leukocyte tethering/rolling, neutrophil-mediated killing of fungus), with signals of vascular remodeling (elastin catabolic process) and growth pathways (Wnt signaling). A glucose-stimulus term adds metabolic context but the dominant pattern ties hemostasis to innate immune responses.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":5},{"id":"GO:0042730","count":5},{"id":"GO:0007596","count":5},{"id":"GO:0042127","count":4},{"id":"GO:1903238","count":4}]},{"hash":"96913653684936187","title":"RNA Pol II Transcription Elongation Regulation","description":"Most prominent GO terms point to regulation of transcription elongation by RNA polymerase II (GO:0006368 and GO:0032968), suggesting the cluster centers on transcription elongation control. Additional related terms include chromatin/ubiquitination processes (e.g., H2A monoubiquitination, K33-linked ubiquitination), which can modulate transcription, while a few other terms (such as tight junction assembly and development) appear sporadic. With no interaction edges, the label reflects a coherent functional theme rather than network connectivity. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006368","count":2},{"id":"GO:0032968","count":2},{"id":"GO:0070830","count":2},{"id":"GO:1900477","count":1},{"id":"GO:0007519","count":1}]},{"hash":"203009104236996440","title":"Immune cell adhesion and signaling","description":"Based on the top GO terms, the cluster centers on immune-related processes (complement activation, B cell proliferation, myeloid apoptotic regulation) and cell adhesion, with additional mentions of migration and GTPase regulation. This suggests a broad group of immune-modulatory and adhesion-associated proteins rather than a single highly specific pathway, so a general label of immune cell adhesion and signaling is most representative.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0006958","count":3},{"id":"GO:1900273","count":2},{"id":"GO:0030890","count":2},{"id":"GO:0060065","count":2}]},{"hash":"900243872672306991","title":"Neuronal and immune signaling","description":"This cluster shows links to neural development and synaptic remodeling (axonogenesis, regulation of synaptic plasticity) as well as immune signaling pathways (T cell receptor signaling, mast cell cytokine production, GPCR desensitization) and cytoskeletal dynamics, suggesting proteins that coordinate signaling and structural changes in both neural and immune contexts.","confidence":"Medium","size":23,"edges":217,"triangles":1146,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031532","count":23},{"id":"GO:0007409","count":23},{"id":"GO:0010898","count":23},{"id":"GO:0032092","count":23},{"id":"GO:0050852","count":23}]},{"hash":"1116610503424839370","title":"Coagulation and innate immunity","description":"The cluster\u2019s terms cluster around the coagulation cascade (complement activation classical pathway, blood coagulation, Factor XII activation) and innate immune responses (neutrophil-mediated killing, leukocyte tethering/rolling). Additional terms touch on extracellular matrix remodeling and development (elastin catabolic process, digestion, Wnt signaling, multicellular growth), but the dominant pattern ties coagulation to immune function with some remodeling context.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":6},{"id":"GO:0007596","count":6},{"id":"GO:0042127","count":4},{"id":"GO:1903238","count":4},{"id":"GO:0060309","count":4}]},{"hash":"243882801726235483","title":"Unknown","description":"The top GO terms span very disparate biological processes (skeletal muscle development, dendritic cell and T-cell differentiation, ubiquitination via K33 linkages, and plant tropisms like phototropism and gravitropism), with little clear unifying function among the proteins. Because the cluster lacks a cohesive theme, a simple, general label is not justifiable.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007519","count":4},{"id":"GO:1900477","count":3},{"id":"GO:1990390","count":3},{"id":"GO:0045497","count":3},{"id":"GO:2000176","count":3}]},{"hash":"59098154275192195","title":"Inflammation and lipid metabolism","description":"The top GO terms cluster around immune/inflammatory processes (response to LPS, inflammatory mediator and chemokine production, complement activation) alongside lipid-related regulation (cholesterol homeostasis), suggesting a theme of inflammatory signaling coupled with lipid metabolism. A few terms (vagina development, chitin catabolic process, lithium response) are outliers, indicating a mixed set rather than a tightly cohesive function. Overall, the dominant pattern points to inflammation with metabolic context.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0042632","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0071638","count":4},{"id":"GO:0060068","count":4},{"id":"GO:0006958","count":4}]},{"hash":"2061584749234966411","title":"Cell division and cytoskeleton dynamics","description":"This cluster shows enrichment for cell cycle-related processes (regulation of meiotic nuclear division, cell division, mitotic sister chromatid segregation) and cytoskeletal remodeling (actin filament depolymerization), with supporting hints from nuclear transport (nuclear pore localization) and general growth-related processes (translation initiation). While a few terms are outliers or obsolete, the dominant theme appears to be proteins involved in mitosis/cell cycle progression and cytoskeletal regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040020","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0090344","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0031081","count":3}]},{"hash":"262259623817705242","title":"Mitochondrial Electron Transport Chain and ATP Synthesis","description":"This cluster is dominated by GO terms tied to mitochondrial respiration: electron transport chain steps (succinate to ubiquinone; ubiquinol to cytochrome c), ATP synthesis coupled to the proton motive force, and cytochrome complex assembly. The presence of a TCA cycle term and redox-homeostasis terms further supports a mitochondria-centric energy production module, indicating proteins functionally linked to oxidative phosphorylation and energy metabolism.","confidence":"High","size":22,"edges":224,"triangles":1411,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0006121","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0006099","count":2},{"id":"GO:0098869","count":2}]},{"hash":"871240198252625747","title":"Cell Cycle Regulation and Morphogenesis Signaling","description":"This cluster shows strong enrichment for DNA-templated transcription and DNA replication, including the DNA replication and centrosome cycle terms, indicating a core cell cycle and transcription program. It also includes signaling and morphogenesis terms such as chemotaxis, T cell receptor signaling, dendrite morphogenesis, and embryonic cranial skeleton morphogenesis, suggesting coordinated signaling during development and cell movement. Although the GO terms are diverse, the common thread is cell cycle control connected to developmental signaling and morphogenesis.","confidence":"Medium","size":22,"edges":8,"triangles":1,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":10},{"id":"GO:0006935","count":9},{"id":"GO:0006260","count":8},{"id":"GO:0006813","count":7},{"id":"GO:0007098","count":6}]},{"hash":"1404946869640170010","title":"Blood coagulation and complement activation with tissue differentiation","description":"This cluster centers on coagulation and classical complement activation, with several differentiation-related GO terms (endodermal and cerebellar granule cell differentiation) and regulatory processes, suggesting a theme of hemostasis/immune signaling coupled with developmental cues. Confidence: Medium","confidence":"","size":22,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035987","count":5},{"id":"GO:0006958","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0070208","count":4},{"id":"GO:0021707","count":4}]},{"hash":"1422722860214559938","title":"Neurodevelopmental signaling and cytoskeletal dynamics","description":"Most of the top terms point to neural development and wiring (dendrite morphogenesis, hippocampus development, negative regulation of axonogenesis) and associated signaling/cytoskeletal processes (JNK cascade, actin cytoskeleton reorganization, phosphorylation, protein stability). While mitotic cell cycle appears, the strongest signals describe neuronal development and cytoskeletal remodeling, suggesting a cluster of proteins involved in neurodevelopmental signaling and neuronal morphology. ","confidence":"Medium","size":22,"edges":12,"triangles":2,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":19},{"id":"GO:0031532","count":17},{"id":"GO:0050852","count":17},{"id":"GO:0048813","count":17},{"id":"GO:0046330","count":17}]},{"hash":"2018062796465455367","title":"Fatty acid and lipid metabolism","description":"The prominent GO terms cluster around lipid biosynthesis and related metabolic pathways (fatty acid biosynthetic process, fatty-acyl-CoA metabolism, PHB biosynthesis, retinol metabolism, phenylacetate catabolic process, and antibiotic biosynthesis), suggesting a metabolic module focused on lipid- and small-molecule metabolism typical of bacterial systems. Some terms like bioluminescence or cell-matrix adhesion appear less central.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":11},{"id":"GO:1902987","count":7},{"id":"GO:0042572","count":6},{"id":"GO:0017000","count":6},{"id":"GO:0042619","count":6}]},{"hash":"890393133686507635","title":"Membrane Solute Transporters","description":"Based on the top GO terms, the proteins are enriched for diverse transmembrane transport activities across ions and nutrients (proline, nitrate, potassium, sialic acid, phosphate, nitrite, galactose, sodium) and a vesicular neurotransmitter loading process. This points to a cluster of membrane transport proteins with broad substrate specificity, hence the label Membrane Solute Transporters.","confidence":"High","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015824","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0015739","count":2},{"id":"GO:0035435","count":2}]},{"hash":"1480184442199862710","title":"Neural signaling and synaptic plasticity","description":"This cluster is dominated by GO terms tied to neuronal signaling and learning-related plasticity, including long-term synaptic potentiation and depression, excitatory postsynaptic potentials, sensory perception, olfactory learning, and tachykinin/GPCR signaling, indicating a cohesive theme of activity-dependent neural communication and plasticity.","confidence":"Medium","size":22,"edges":25,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0048169","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0050975","count":3},{"id":"GO:0060292","count":3}]},{"hash":"1553851613913400966","title":"Neural synaptic regulation and angiogenesis","description":"The top GO terms center on neural activity and plasticity (glutamatergic synaptic transmission, synaptic plasticity, learning) alongside vascular development (angiogenesis, multicellular organism development) and related signaling/inflammatory processes. This pattern suggests proteins involved in coordinating neural signaling with vascular remodeling, rather than a single, narrow function. Confidence: Medium","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051968","count":4},{"id":"GO:0045766","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0042346","count":3}]},{"hash":"1794176224477680188","title":"Diverse transmembrane transporters","description":"The top GO terms show transport activities across membranes for a wide range of substrates: potassium ions, nitrite/nitrate, sugars (fucose, arabinose, sialic acid), vitamins, xenobiotics, and even neurotransmitter loading into synaptic vesicles. This pattern indicates a cluster of membrane transporter proteins with broad substrate specificity, rather than a single metabolic enzyme or pathway.","confidence":"High","size":22,"edges":15,"triangles":1,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0006004","count":3},{"id":"GO:0042891","count":3},{"id":"GO:0098700","count":3},{"id":"GO:0015707","count":3}]},{"hash":"1111065413386665536","title":"Developmental cell adhesion and ECM interactions","description":"This cluster centers on adhesion to the extracellular matrix and cell\u2011cell contacts implicated in tissue morphogenesis across multiple systems (retina, skeletal/basement membrane development, ossification, and paranodal/axonal junction assembly), indicating ECM-mediated development and junction organization as the common theme.","confidence":"High","size":22,"edges":5,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007160","count":10},{"id":"GO:0007157","count":10},{"id":"GO:0060042","count":9},{"id":"GO:0032836","count":9},{"id":"GO:0001501","count":9}]},{"hash":"1657118678286560582","title":"RNA processing and translation initiation regulation","description":"The top GO terms center on mRNA splicing, stability, and translation initiation, indicating a cohesive cluster of proteins involved in RNA maturation and control of protein synthesis initiation.","confidence":"High","size":22,"edges":230,"triangles":1520,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":13},{"id":"GO:0006378","count":11},{"id":"GO:0045292","count":11},{"id":"GO:0031047","count":11},{"id":"GO:0048026","count":11}]},{"hash":"1591133551739065246","title":"Growth signaling and cell cycle regulation","description":"The top terms cluster around regulation of kinase signaling (protein serine/threonine kinase activity, autophosphorylation), cell proliferation and the mitotic cycle, and protein turnover (ubiquitin-mediated degradation), with supporting processes in mRNA transport and growth. While some terms touch on development or immune responses, the strongest shared theme is signaling-driven control of growth and cell division.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035264","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0007338","count":4},{"id":"GO:0071902","count":4},{"id":"GO:0071456","count":4}]},{"hash":"2001376641398175773","title":"DNA Replication, Repair, and Transcription Initiation","description":"This cluster centers on genome maintenance and transcriptional control, with many terms tied to DNA replication (primer synthesis, unwinding, topological changes), DNA repair and the SOS damage response, plus transcription initiation (RNA Pol II promoter clearance/open complex). Nonsense-mediated decay reflects RNA quality control linked to gene expression, while the hair cell differentiation term appears peripheral. Overall, the proteins coalesce around DNA metabolism and transcription regulation.","confidence":"Medium","size":22,"edges":8,"triangles":0,"max_degree":4,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000184","count":13},{"id":"GO:0006306","count":11},{"id":"GO:0009432","count":11},{"id":"GO:0006269","count":11},{"id":"GO:0006268","count":11}]},{"hash":"1600229897924641963","title":"Craniofacial and neural development","description":"This cluster centers on developmental processes of neural and craniofacial tissues: inner ear development, facial nucleus development, roof of mouth development, midbrain-hindbrain boundary development, rhombomere development, spinal cord motor neuron specification, Purkinje cell differentiation, and cartilage development. Together these GO terms point to CNS patterning and craniofacial morphogenesis, with a minority term (atrioventricular node development) not altering the overall theme. The proteins are thus best viewed as a unit driving neural and facial/ear development programs.","confidence":"High","size":22,"edges":41,"triangles":0,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0048839","count":20},{"id":"GO:0021754","count":18},{"id":"GO:0060021","count":18},{"id":"GO:0030917","count":18},{"id":"GO:0021520","count":18}]},{"hash":"26824260477525952","title":"Innate immune response: complement activation and neutrophil function","description":"The dominant GO terms cluster around innate immunity: activation of classical and lectin complement pathways, response to lipopolysaccharide, and neutrophil-driven defense and leukocyte adhesion, suggesting a cohesive theme of innate immune response. A few terms (midbrain development, elastin catabolic process, transcription regulation) are less clearly connected and may reflect annotation noise or multifunctional proteins, but the core signal is innate immunity.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0006958","count":8},{"id":"GO:0001867","count":8},{"id":"GO:0032496","count":8},{"id":"GO:0030901","count":8}]},{"hash":"839091734779334848","title":"DNA Damage Response and Replication Control","description":"The top terms point to DNA damage response and DNA replication regulation (e.g., repair of double-strand breaks, responses to hydroxyurea, bleomycin, and cisplatin, and negative regulation of DNA replication). While there are unrelated terms like lung development and actin cytoskeleton organization present, the strongest cohesive signal is the coordination of damage sensing/repair with replication control. Confidence: Medium","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030866","count":3},{"id":"GO:0030324","count":2},{"id":"GO:0048754","count":2},{"id":"GO:2000781","count":2},{"id":"GO:0072711","count":2}]},{"hash":"2249389044207164907","title":"Neuromodulatory GPCR signaling and drug response","description":"The top GO terms point to GPCR signaling activating adenylate cyclase, neural regulation of pain and sensory processing, prepulse inhibition, responses to amphetamine and morphine, and modulation of glutamatergic synaptic transmission, all indicating a neural signaling and neuromodulatory module influenced by drug exposure; the involvement of ERK signaling and visual learning supports broader neural plasticity. Electron transport chain terms may reflect neuronal energy needs, but the dominant pattern is neural signaling and drug responsiveness rather than metabolism.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":11},{"id":"GO:0045777","count":11},{"id":"GO:0022900","count":11},{"id":"GO:0070374","count":8},{"id":"GO:0060134","count":7}]},{"hash":"2035169782570597841","title":"Membrane Transporters and Vesicle Loading","description":"This cluster is dominated by GO terms for transmembrane transport of ions and small molecules (potassium, nitrite, sialic acid) and vesicle loading of neurotransmitters, pointing to membrane transport and vesicle trafficking as the central function. A non-transport term (hemocyte migration) appears but does not outweigh the core transport signals. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:1904261","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0035099","count":3},{"id":"GO:0055114","count":2}]},{"hash":"1240422110735902839","title":"Vitamin K quinone biosynthesis","description":"The cluster shows strong representation of GO terms for menaquinone (vitamin K2) and phylloquinone (vitamin K1) biosynthesis, indicating a core function in vitamin K quinone production. Additional terms for central metabolism (fatty acid beta-oxidation, TCA cycle, various catabolic processes) suggest these proteins participate in broader energy metabolism, with quinone biosynthesis as a unifying theme. Confidence: Medium","confidence":"","size":21,"edges":208,"triangles":1293,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009234","count":7},{"id":"GO:0006635","count":7},{"id":"GO:0006574","count":7},{"id":"GO:0042372","count":7},{"id":"GO:0010124","count":7}]},{"hash":"1170539624706991215","title":"Nuclear RNA processing and transcription termination","description":"The cluster is dominated by GO terms related to nuclear mRNA surveillance, exosome-dependent RNA decay, mRNA decapping/decay, and termination/elongation regulation of RNA polymerase II transcription, pointing to a cohesive group of proteins involved in nuclear RNA metabolism and transcription termination control. A single outlier term about larval cuticle development is likely noise or a misannotation, but the prevailing signals strongly support a role in RNA processing and transcription termination. ","confidence":"High","size":21,"edges":157,"triangles":593,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":10},{"id":"GO:0071028","count":1},{"id":"GO:0034428","count":1},{"id":"GO:0071044","count":1},{"id":"GO:0030847","count":1}]},{"hash":"1255607224746754485","title":"Larval chitin-based cuticle formation and endosomal sorting","description":"The top GO terms cluster around larval chitin-containing cuticle development and multivesicular body (MVB)\u2013related trafficking/sorting, plus associated ER-targeting and proteolytic processing via the MVB pathway. This points to a coordinated role in production of the larval cuticle and vesicle-mediated transport/secretion. Some cell cycle terms are present but appear ancillary to the main vesicle trafficking and cuticle formation theme.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0010458","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0036258","count":3},{"id":"GO:0071985","count":3}]},{"hash":"1980560209464460205","title":"Ribosome biogenesis and translation","description":"This cluster is dominated by GO terms for ribosome biogenesis (including ribosomal small subunit biogenesis), cytoplasmic translation, and tRNA modification, pointing to a group of proteins involved in assembling ribosomes and supporting protein synthesis. Additional terms related to cell cycle and division may reflect coordination between growth and division, but the core signal centers on ribosome assembly and translation functions.","confidence":"High","size":21,"edges":2,"triangles":0,"max_degree":1,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006400","count":5},{"id":"GO:0051301","count":5},{"id":"GO:1903833","count":5},{"id":"GO:1901001","count":5},{"id":"GO:0090529","count":5}]},{"hash":"1294093024997196091","title":"Immune and Neural Development Signaling","description":"The GO terms cluster around developmental processes in immune and neural contexts (thymus and placenta development, cerebellar cortex formation) and associated signaling pathways (T cell receptor signaling, insulin receptor signaling, MAPK-related activation), plus growth regulation. This suggests a unifying theme of signaling events driving development across tissues, rather than a single precise pathway. ","confidence":"Medium","size":21,"edges":208,"triangles":1293,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000187","count":12},{"id":"GO:0048538","count":12},{"id":"GO:0071276","count":12},{"id":"GO:0001890","count":12},{"id":"GO:0050852","count":12}]},{"hash":"503256283834411461","title":"Diverse Developmental Processes","description":"Based on the top GO terms, several entries center on development and morphogenesis (spermatid development, neural crest cell migration, sensory organ precursor division, otolith morphogenesis), with additional governance by cellular regulation processes (proteolysis, macroautophagy) and signaling modulation (negative regulation of T cell receptor signaling). While there are some plant-specific terms (abscisic acid homeostasis, chloroplast movement), the common thread appears to be broad developmental regulation and morphogenetic processes across tissues. Hence a label like Diverse Developmental Processes.","confidence":"Medium","size":21,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":3},{"id":"GO:0050860","count":2},{"id":"GO:0016239","count":2},{"id":"GO:0006508","count":2},{"id":"GO:1903045","count":2}]},{"hash":"1671490583643001588","title":"Nuclear import and pore complex assembly","description":"The dominant GO terms describe nucleocytoplasmic transport: nuclear pore complex assembly, NLS-bearing protein import into the nucleus, and ribosomal protein import into the nucleus, with related translocation processes. While there are a few terms related to protein turnover and cell division, the strongest signal is nuclear transport and pore assembly.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0060188","count":9},{"id":"GO:0051292","count":9},{"id":"GO:0006607","count":9},{"id":"GO:0043547","count":9},{"id":"GO:0000060","count":9}]},{"hash":"1251928995450811969","title":"Insect embryogenesis and cuticle formation","description":"The top term is larval chitin-based cuticle development, which strongly suggests insect-specific development. Other terms point to embryonic morphogenesis and axis specification, plus signaling pathway regulation, aligning with developmental processes rather than a single metabolic function. So this cluster appears to capture proteins involved in insect embryogenesis and cuticle formation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":7},{"id":"GO:0071805","count":2},{"id":"GO:0009948","count":1},{"id":"GO:0045880","count":1},{"id":"GO:0040037","count":1}]},{"hash":"2164099143914907869","title":"Bacterial lipid metabolism and energy pathways","description":"The top GO terms cluster around lipid-related biosynthesis and metabolism (lipoteichoic acid biosynthesis, medium-chain fatty-acyl-CoA metabolism and transport, bile acid metabolism, menaquinone biosynthesis) and connected catabolic processes, pointing to lipid metabolism and energy-generation in bacteria. Bioluminescence can align with microbial energy processes, while seed coat development is likely an annotation artifact. Overall, this cluster seems to group proteins involved in bacterial lipid biosynthesis and related energetic pathways.","confidence":"Medium","size":21,"edges":61,"triangles":27,"max_degree":13,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0070395","count":12},{"id":"GO:0008218","count":9},{"id":"GO:0009437","count":9},{"id":"GO:0010124","count":9},{"id":"GO:0036112","count":9}]},{"hash":"1925789452335328021","title":"Chromatin Regulation in Development","description":"The dominant GO terms point to chromatin state control (heterochromatin formation and histone modification) and transcription regulation, suggesting a core function in regulating gene expression via chromatin. The inclusion of developmental processes (spermatid development, sperm DNA condensation, vitellogenesis, muscle and heart morphogenesis) indicates this regulation is linked to development, even though some terms are less related. Overall, the cluster appears to group chromatin regulation with developmental programs.","confidence":"Medium","size":21,"edges":143,"triangles":510,"max_degree":20,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0030466","count":11},{"id":"GO:0043966","count":10},{"id":"GO:0000122","count":9},{"id":"GO:0031509","count":8},{"id":"GO:0007286","count":8}]},{"hash":"1361964148978714212","title":"Retinal GPCR Signaling and Dopamine Regulation","description":"The top GO terms center on GPCR signaling (adenylate cyclase activation/inhibition, receptor internalization), regulation of dopamine secretion, photoreceptor cell maintenance, and related adrenergic signaling. Together these point to GPCR-mediated communication in retinal cells, including dopamine release and photoreceptor upkeep, making a retina-focused GPCR/dopamine theme the best cohesive label, despite some systemic terms appearing elsewhere. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":21},{"id":"GO:0022900","count":21},{"id":"GO:0007190","count":21},{"id":"GO:0010579","count":21},{"id":"GO:0031635","count":20}]},{"hash":"783391448511808750","title":"Growth and protein turnover regulators","description":"The top GO terms point to regulation of growth and signaling (multicellular growth; SREBP signaling; GTPase activity and tyrosine kinase activity regulation) together with protein homeostasis and trafficking processes (ubiquitin ligase activity, ERAD, translation initiation, and nuclear pore localization). This suggests a cluster of proteins that coordinate growth signaling with proteostasis and transport. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0007568","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0032933","count":6},{"id":"GO:1904668","count":6},{"id":"GO:0001731","count":6}]},{"hash":"1085896551452352116","title":"Glycosylation and fucosylation processes","description":"The top GO terms are dominated by glycosylation-related categories: protein glycosylation, N-glycan fucosylation, and Lewis a epitope biosynthesis, plus L-fucose catabolic process, indicating enzymes or factors involved in building and modifying glycans, especially fucose-containing structures. A few terms touch on immune cell differentiation and neuronal migration, which can be influenced by glycosylation states, but the core signal across the cluster is glycan biosynthesis/modification. Hence the chosen label reflects the shared glycosylation theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":4},{"id":"GO:0002361","count":3},{"id":"GO:0010493","count":3},{"id":"GO:0002522","count":3},{"id":"GO:0036071","count":3}]},{"hash":"1530072548168844950","title":"Gonadal development and steroid metabolism","description":"Most of the top GO terms point to reproductive biology and steroid-related metabolism, such as female gonad development, androgen metabolic process, prostate gland growth, and related catabolic/methylation pathways. While there are also a few unrelated terms (potassium ion response, endothelial adhesion, immobilization stress), the strongest signals cluster around gonadal development and steroid/hormone metabolism, suggesting a functional theme in reproductive hormone pathways.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":10},{"id":"GO:0008209","count":9},{"id":"GO:0035865","count":9},{"id":"GO:0010430","count":9},{"id":"GO:0060736","count":9}]},{"hash":"116245150282534376","title":"Auditory system development and synapse formation","description":"The cluster is enriched for nervous system development, inner ear morphogenesis, and sensory perception of sound, alongside cell\u2013cell adhesion and synapse assembly terms. This points to roles in neural connection formation within the auditory system, including ear development and mechanosensory signaling. Despite some miscellaneous or obsolete terms, the dominant theme ties to ear/NNS development and synaptic connectivity.","confidence":"High","size":21,"edges":10,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":7},{"id":"GO:0046718","count":6},{"id":"GO:0051965","count":5},{"id":"GO:0007156","count":5},{"id":"GO:0007399","count":5}]},{"hash":"1220538969523259931","title":"Diverse metabolite biosynthesis","description":"The top GO terms are dominated by biosynthetic processes for a variety of small-molecule metabolites (biotin, sterol, menaquinone, poly-hydroxybutyrate, antibiotic, adenosine) with some redox-related detoxification terms. This suggests the cluster represents general metabolic biosynthesis capabilities across diverse compounds rather than a single, cohesive pathway, so a label like \"Diverse metabolite biosynthesis\" is appropriate and informative.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0035754","count":5},{"id":"GO:0042619","count":5},{"id":"GO:0009102","count":4},{"id":"GO:0016126","count":4}]},{"hash":"224426411957091775","title":"Ubiquitin-Dependent Protein Degradation & Metal Stress Response","description":"Most top GO terms point to ubiquitin-mediated proteolysis, including ubiquitin-dependent protein catabolic process, SCF-dependent proteasomal degradation, and polyubiquitination. Several terms also reflect cellular responses to heavy metals (cadmium, arsenic, methylmercury) and oxidative stress-induced apoptotic signaling, suggesting the proteins collectively participate in proteostasis with stress-response regulation. This cohesive pattern supports a label centered on the ubiquitin-proteasome system with metal-stress connections.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0031146","count":10},{"id":"GO:0030174","count":7},{"id":"GO:1903378","count":7},{"id":"GO:0000083","count":7}]},{"hash":"711805611893079618","title":"Ubiquitin-dependent proteolysis in meiosis and spindle assembly","description":"This cluster is dominated by GO terms for ubiquitin-mediated proteolysis (ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal pathways) and terms tied to meiotic spindle function (spindle assembly in female meiosis I) and oocyte maturation. The co-occurrence of ubiquitin-proteasome\u2013driven protein turnover with microtubule/spindle activities suggests a coherent module focused on proteolysis that regulates meiosis and spindle dynamics in oocytes. Confidence reflects the strong, overarching linkage among these terms.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0030433","count":7},{"id":"GO:0007057","count":7},{"id":"GO:0070544","count":7},{"id":"GO:0031146","count":7}]},{"hash":"366665989990514574","title":"Nuclear transcription, RNA processing, and chromatin modification","description":"The most represented GO terms point to nuclear gene expression processes: DNA-templated transcription, mRNA splicing, and histone methylation, indicating regulation of transcription and RNA processing along with chromatin modification. Other terms are ancillary or obsolete but do not override the core theme. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007568","count":5},{"id":"GO:0008584","count":5},{"id":"GO:0030433","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0051567","count":4}]},{"hash":"1864250982620375378","title":"Cranial Nerve and Sensory Neuron Development","description":"These proteins show strong signals for neural crest\u2013driven cranial nerve formation and sensory wiring: facioacoustic ganglion development, facial nerve organization, and sensory neuron axon guidance are prominent, with Hedgehog signaling (Smoothened) and neuropilin-associated axon guidance supporting neural patterning. A few terms related to broader morphogenesis or immune pathways appear as noise. Overall, the cluster centers on cranial nerve and sensory neuron morphogenesis.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048903","count":2},{"id":"GO:0045880","count":2},{"id":"GO:1902378","count":2},{"id":"GO:0060672","count":2},{"id":"GO:0060982","count":2}]},{"hash":"1663534890451471947","title":"Notch-regulated cardiac development and ion transport","description":"The cluster\u2019s top terms include Notch signaling pathway regulation and cardiac development terms (secondary heart field proliferation, right atrium morphogenesis), alongside potassium and sodium ion transmembrane transport. This points to proteins potentially involved in signaling interfaces and membrane transport during heart development, with a Notch-centric theme being the strongest connection. Some terms (neuronal differentiation, mRNA processing) may be incidental, but the Notch\u2013cardiac axis plus ion transport provides a coherent interpretation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0045746","count":2},{"id":"GO:0060843","count":2},{"id":"GO:0021707","count":2}]},{"hash":"2204254261528978756","title":"Unknown","description":"The GO terms cover a mix of processes including apical protein localization, neural plate morphogenesis, endosome protein trafficking, Rho signaling, DNA repair and checkpoints, Toll signaling, oocyte axis specification, and antibacterial peptide biosynthesis. With no edges connecting the proteins and no clear single functional theme linking these terms, there isn\u2019t a coherent common function for the cluster. ","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045176","count":2},{"id":"GO:0001839","count":2},{"id":"GO:1902966","count":2},{"id":"GO:0035023","count":2},{"id":"GO:2000781","count":2}]},{"hash":"606837498477008937","title":"Translation machinery, mRNA decay, antibiotic response","description":"The top GO terms are dominated by translation-related processes (translation, cytoplasmic translation, initiation/elongation/termination) and regulation of translational fidelity, plus a deadenylation-dependent mRNA decay term and selenocysteine incorporation. This points to a coherent module centered on the translation apparatus and its post-transcriptional quality control, with possible antibiotic responsiveness, suggesting a translation-centric program rather than disparate processes.","confidence":"High","size":20,"edges":187,"triangles":1089,"max_degree":19,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":15},{"id":"GO:0006415","count":6},{"id":"GO:0046677","count":6},{"id":"GO:0002181","count":5},{"id":"GO:0006413","count":4}]},{"hash":"551791002045999471","title":"Ribosome biogenesis and translation initiation","description":"The cluster is dominated by GO terms for rRNA maturation (5.8S, SSU, LSU) and maturation from tricistronic transcripts, plus translation initiation and reinitiation, pointing to roles in ribosome assembly and translation. A few developmental terms appear but are likely incidental; overall a cohesive ribosome/translation signature.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000466","count":4},{"id":"GO:0000463","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0001731","count":3},{"id":"GO:0002188","count":3}]},{"hash":"2068375694228247566","title":"Amino acid catabolism and central carbon metabolism","description":"The top GO terms cluster around catabolic and biosynthetic steps for several amino acids (L-alanine, glyoxylate, L-kynurenine, serine) and core carbon metabolism (pyruvate formation, TCA cycle), indicating a metabolic module that ties amino acid turnover to central metabolism. The presence of Notch signaling is minor relative to the metabolism terms, so the theme is metabolic rather than signaling-focused.","confidence":"Medium","size":20,"edges":168,"triangles":860,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042853","count":5},{"id":"GO:0009436","count":5},{"id":"GO:0097053","count":4},{"id":"GO:0007219","count":4},{"id":"GO:0042866","count":4}]},{"hash":"529936465299230991","title":"Neuronal signaling, synaptic plasticity, and receptor trafficking","description":"The proteins show enrichment for ion transport (calcium and potassium), regulation of synaptic transmission, receptor internalization and recycling, and memory-related processes (long- and medium-term memory, conditioned taste aversion). This points to neural signaling and synaptic plasticity with receptor trafficking; a related sensory development term (anterior lateral line development) reinforces a neuronal/sensory context. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006816","count":6},{"id":"GO:0007616","count":6},{"id":"GO:0031623","count":6},{"id":"GO:0001919","count":6},{"id":"GO:0072375","count":5}]},{"hash":"94535861226813056","title":"Protein degradation and substrate catabolism","description":"Top GO terms indicate a theme of protein turnover (protein catabolic process; ubiquitin-dependent ERAD pathway) alongside substrate-specific catabolism (beta-alanine, L-isoleucine, propylene, camphor) and related metabolic processes. This suggests the cluster groups proteins involved in protein quality control and broad catabolic metabolism rather than a single, cohesive pathway. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030163","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0042391","count":2},{"id":"GO:0019483","count":2}]},{"hash":"14917214691900275","title":"Diverse Metabolic Pathways with Cell Cycle Links","description":"The top GO terms are mostly metabolic processes (glycogen biosynthesis, valine catabolism, methanol metabolism, fatty-acyl-CoA and carnitine metabolism), with a smaller set related to cell division and ubiquitination (mitotic transition and K11-linked ubiquitination). This suggests the cluster reflects general metabolism with some coupling to cell-cycle regulation, rather than a single specific pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0005978","count":4},{"id":"GO:0009409","count":4},{"id":"GO:0006574","count":4},{"id":"GO:0015945","count":4}]},{"hash":"289123420846495152","title":"Apoptosis and Developmental Signaling","description":"These proteins are enriched for apoptotic process, regulation of canonical Wnt signaling, Hippo signaling, and differentiation programs (keratinocyte differentiation, dendrite morphogenesis), along with transcriptional regulation. The shared theme is cell fate decisions driven by major signaling networks across development and tissue contexts, so labeling the cluster as \u201cApoptosis and Developmental Signaling\u201d is representative of its core functions.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006915","count":14},{"id":"GO:0090263","count":14},{"id":"GO:0030216","count":14},{"id":"GO:0035329","count":14},{"id":"GO:0060044","count":14}]},{"hash":"1311993350011633173","title":"Cell Cycle and Developmental Signaling","description":"This cluster centers on core cell-cycle processes (mitotic cell cycle, DNA replication, translation) with phosphorylation and signaling inputs, plus developmental pathways (Wnt) and immune signaling (B cell receptor) and muscle development. The dominant themes are cell proliferation and growth signaling connected to development, with some ancillary cytoskeletal remodeling. Confidence: Medium","confidence":"","size":20,"edges":120,"triangles":372,"max_degree":18,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0018107","count":3},{"id":"GO:0007519","count":3},{"id":"GO:0007095","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0050853","count":3}]},{"hash":"54121415437045388","title":"Unknown","description":"The top GO terms span plant development (nodulation, regulation of secondary shoot formation, auxin stimulus), metabolism (amino acid transmembrane transport, phospholipid translocation), pigment and morphogenesis processes (ommochrome biosynthetic process, sorocarp morphogenesis), and even non-plant processes, indicating no single cohesive function ties the proteins together. Thus, there is no clear common theme to assign a specific, meaningful label.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007584","count":5},{"id":"GO:0045332","count":4},{"id":"GO:0006727","count":3},{"id":"GO:0031288","count":3},{"id":"GO:0055099","count":3}]},{"hash":"1401763257327681632","title":"Arabinogalactan Protein Glycosylation and Seed Mucilage Synthesis","description":"The cluster is driven by GO terms tied to arabinogalactan protein metabolism, hydroxyproline O-linked glycosylation, and seed mucilage biosynthesis, along with root hair development and cell\u2013wall\u2013related processes in plants. This points to plant cell wall glycoprotein maturation and mucilage production as the central theme.","confidence":"High","size":20,"edges":75,"triangles":197,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":8},{"id":"GO:0080147","count":7},{"id":"GO:0010405","count":7},{"id":"GO:0001744","count":7},{"id":"GO:0010493","count":7}]},{"hash":"1253821299123060737","title":"Integrin-mediated adhesion and ECM remodeling","description":"This cluster is driven by GO terms tied to adhesion and extracellular matrix interactions: integrin-mediated signaling, heterotypic and cell-matrix adhesion, cellular extravasation, and metallopeptidase-mediated remodeling. Together these suggest a cohesive role in cell adhesion to the ECM and ECM remodeling, processes central to cell migration and tissue dynamics. The other terms (stamen formation, chlorophyll biosynthesis, dendrite regeneration, endodermal differentiation) appear less cohesive with the core adhesion theme and may reflect cross-species annotations or secondary associations. ","confidence":"Medium","size":20,"edges":28,"triangles":1,"max_degree":13,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0007229","count":10},{"id":"GO:0034113","count":10},{"id":"GO:0007161","count":10},{"id":"GO:0045123","count":10},{"id":"GO:0035987","count":10}]},{"hash":"948777506689318246","title":"Gene expression and genome maintenance","description":"These proteins link gene expression processes (translation, mRNA processing, ubiquitination) with genome maintenance (cell cycle, DNA replication, telomere maintenance). Peripheral terms like response to antibiotic or mechanical stimulus are present but do not define the core function.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0016567","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0071260","count":2}]},{"hash":"1193726027933787175","title":"Endocytosis and Receptor Trafficking","description":"The top GO terms point to internalization and trafficking processes\u2014GPCR internalization, endocytic recycling, and pinocytosis\u2014supporting a membrane trafficking and receptor cycling theme. Additional terms suggest related membrane organization and mitochondrion-associated transport, but the core signal is endocytosis/receptor trafficking.","confidence":"Medium","size":20,"edges":18,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0051262","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0032456","count":3},{"id":"GO:0002031","count":3}]},{"hash":"673627838632132215","title":"Auditory system development and synapse assembly","description":"The cluster centers on sensory perception of sound and mechanical stimulus, along with nervous system development and synapse assembly, and includes cell adhesion and ion transport terms typical of mechanosensory neurons and synaptic connectivity. The occasional bone-related term may be incidental but does not override the dominant auditory/neural theme.","confidence":"High","size":20,"edges":6,"triangles":1,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":6},{"id":"GO:0007626","count":6},{"id":"GO:0007157","count":6},{"id":"GO:0007156","count":6},{"id":"GO:0051965","count":6}]},{"hash":"1428751886379592898","title":"Embryonic Development and Morphogenesis","description":"The terms cluster around embryonic development and organogenesis, including pancreas/endocrine system development, placenta/trophoblast differentiation, left-right axis formation, cartilage morphogenesis, and general tissue morphogenesis, suggesting these proteins contribute to developmental processes and tissue formation; a few terms are broader regulatory processes but still fit the developmental theme.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0014909","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0007313","count":3}]},{"hash":"1852603491303607881","title":"Unknown","description":"This cluster shows a wide mix of GO terms including protein folding, mitochondrial targeting, autophagy-related processes, Toll signaling, fertilization-related binding, and some metabolism-related terms, with no clear single function uniting them. Therefore there isn\u2019t a cohesive, dominant theme to name it, so the label Unknown is appropriate.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006457","count":2},{"id":"GO:0007339","count":2},{"id":"GO:0008063","count":2},{"id":"GO:0006696","count":1},{"id":"GO:0045039","count":1}]},{"hash":"2209588270116067839","title":"Embryonic organ morphogenesis","description":"The top GO terms point to a broad set of embryonic development and tissue morphogenesis across multiple organs (palate, heart, lung, hindlimb, oviduct, thyroid differentiation, etc.), indicating a general theme of embryonic organogenesis rather than a single pathway or tissue-specific function.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":3},{"id":"GO:0010085","count":2},{"id":"GO:0060066","count":2},{"id":"GO:0060317","count":2},{"id":"GO:0055009","count":2}]},{"hash":"822865445947815044","title":"Cell-cycle and signaling","description":"The cluster is dominated by mitotic cell cycle and DNA replication terms (both 17), indicating a core connection to cell division. Additional, more diverse terms (neural/dendrite morphogenesis, dopamine/glucose response, JNK and PI3K signaling) suggest broader regulatory or signaling roles that can accompany proliferation, but the strong mitotic signals anchor the theme around cell-cycle control with supporting signaling pathways.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000278","count":17},{"id":"GO:0006260","count":17},{"id":"GO:0031532","count":16},{"id":"GO:0050852","count":16},{"id":"GO:0048813","count":16}]},{"hash":"9622966920182512","title":"Ubiquitin-Mediated Immune Regulation","description":"The top GO terms show strong emphasis on ubiquitination (protein ubiquitination, ubiquitin-dependent ERAD, ubiquitin-dependent protein catabolic process, autoubiquitination) together with immune functions (innate immune response, defense against virus, T cell homeostasis, TFH differentiation, lymph node development). This suggests a cohesive role in regulating immune signaling via ubiquitination, affecting both innate/adaptive responses and lymphoid development.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0016567","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0042787","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0051607","count":5}]},{"hash":"1291655205501453927","title":"Wnt-driven angiogenesis and endothelial differentiation","description":"The top GO terms cluster around Wnt signaling, endothelial proliferation, and venous endothelial differentiation, indicating a shared role in vascular development and angiogenesis. While there are inflammatory/pain-related terms present (pain response, capsazepine, salicylic acid), the strongest signal ties to Wnt-mediated vascular growth and endothelial differentiation, suggesting these proteins function together in angiogenesis within an inflammatory context.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":4},{"id":"GO:0048265","count":4},{"id":"GO:1903589","count":3},{"id":"GO:0071901","count":3},{"id":"GO:1901594","count":3}]},{"hash":"747129832652617014","title":"Ubiquitin-Dependent Protein Degradation","description":"The cluster is dominated by GO terms related to ubiquitination and ubiquitin-dependent proteolysis (e.g., ubiquitin-dependent protein catabolic process, protein ubiquitination, and K63-linked ubiquitination) and includes an ERAD-related term, all pointing to ubiquitin\u2011mediated protein turnover. A peripheral B cell receptor signaling term is present but not central to the cluster's primary function. Overall, the proteins appear linked to tagging substrates for degradation via the ubiquitin-proteasome system. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0016567","count":5},{"id":"GO:1901253","count":5},{"id":"GO:0070534","count":5},{"id":"GO:0050853","count":5}]},{"hash":"251735485958107807","title":"Calcium-driven muscle function and cytoskeleton dynamics","description":"GO terms point to calcium-dependent regulation of skeletal muscle contraction, calcium ion transport, and cytoskeletal remodeling (microtubule polymerization, centrosome separation), along with neuronal synaptic plasticity signals; lipid storage and cholesterol homeostasis appear as secondary associations.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019915","count":2},{"id":"GO:0042632","count":2},{"id":"GO:0014819","count":2},{"id":"GO:0006816","count":2},{"id":"GO:0006915","count":2}]},{"hash":"536488180575786336","title":"Hematopoiesis and Immune Homeostasis","description":"This cluster centers on blood and immune cell development and maintenance, with terms for hemopoiesis, T and B cell homeostasis, stem cell differentiation, and platelet formation. It also includes immune signaling (response to lipopolysaccharide) and regulation of NF-kappaB activity, pointing to coordinated hematopoietic/immune regulation rather than a single pathway.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043029","count":3},{"id":"GO:0030220","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0030097","count":3},{"id":"GO:0048863","count":3}]},{"hash":"1459446873775336724","title":"Dopamine/Adrenergic GPCR Signaling and Phototransduction","description":"This cluster is dominated by GPCR signaling involving dopamine and adrenergic receptors, with strong associations to adenylate cyclase (cAMP) and phospholipase C pathways, plus GPCR desensitization. The inclusion of phototransduction and heart development terms fits the broader GPCR signaling role in light sensing and cardiac signaling, making this a cohesive dopamine/adrenergic GPCR functional cluster.","confidence":"High","size":19,"edges":79,"triangles":144,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":19},{"id":"GO:0043950","count":19},{"id":"GO:0071880","count":19},{"id":"GO:0007603","count":19},{"id":"GO:0060158","count":19}]},{"hash":"2035918692409755600","title":"Vitamin and amino acid biosynthesis","description":"The cluster is dominated by GO terms for biosynthesis of vitamins (biotin, cobalamin), amino acids (lysine, histidine), and porphyrin/heme pathways, with additional antibiotic biosynthesis signals. This pattern indicates a cohesive metabolic biosynthesis module spanning multiple related pathways, justifying the label.","confidence":"High","size":19,"edges":125,"triangles":424,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009102","count":8},{"id":"GO:0019878","count":8},{"id":"GO:0006782","count":8},{"id":"GO:0017000","count":6},{"id":"GO:0055114","count":6}]},{"hash":"1976689210166758558","title":"Sterol and fatty acid biosynthesis","description":"The cluster shows enrichment for sterol and fatty acid biosynthetic processes (ergosterol and cholesterol biosynthesis via lathosterol, fatty acid biosynthesis, ether lipid metabolism, and related sterol oxidation), indicating lipid metabolism as the unifying theme. Some terms like B cell chemotaxis and myelin maintenance appear peripheral but do not override the lipid biosynthesis signal.","confidence":"High","size":19,"edges":22,"triangles":4,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0035754","count":5},{"id":"GO:0080065","count":5},{"id":"GO:0032286","count":5},{"id":"GO:0046485","count":5},{"id":"GO:0006675","count":5}]},{"hash":"1467489050023806637","title":"Organelle protein import and ribosome biogenesis","description":"This cluster is driven by GO terms for importing proteins into mitochondria and chloroplasts (GO:0045039, GO:0030150, GO:0045037) and for ribosomal subunit biogenesis (GO:0042273, GO:0042274), pointing to a cohesive theme of organelle protein targeting and assembly of organelle ribosomes. Some unrelated terms appear but do not override the main pattern.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045039","count":3},{"id":"GO:0030150","count":2},{"id":"GO:0000002","count":2},{"id":"GO:0032094","count":2},{"id":"GO:0045037","count":2}]},{"hash":"1611861853498482321","title":"Retinoid metabolism and signaling","description":"The top GO terms are dominated by retinol/retinal metabolic processes and regulation of retinoic acid receptor signaling, suggesting a cohesive cluster centered on vitamin A metabolism and retinoid signaling pathways. Other terms (sugar metabolism, plant hormone response, potassium transport) likely reflect broader annotations or cross-membership but are secondary to the retinoid-focused theme.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":17},{"id":"GO:0042574","count":16},{"id":"GO:0046370","count":12},{"id":"GO:0009414","count":11},{"id":"GO:0008209","count":11}]},{"hash":"177175596366141107","title":"Glycan biosynthesis and glycosylation","description":"This cluster centers on glycan-related processes, including protein glycosylation, teichoic acid, and glycosaminoglycan biosynthesis (hyaluronan, keratan sulfate), as well as related glycan-modifying steps. The mix of biosynthetic and modification terms across diverse organisms suggests a broad theme around carbohydrate assembly and decoration, rather than a single clean pathway, justifying a glycan-focused label.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0006486","count":4},{"id":"GO:0045493","count":3},{"id":"GO:0019350","count":3},{"id":"GO:0005989","count":3}]},{"hash":"518754345861058882","title":"GTPase-Mediated Migration and Polarity Signaling","description":"The cluster centers on small GTPase\u2013mediated signal transduction and related processes such as regulation of GTPase activity, cell migration, and establishment of epithelial polarity, with supportive links to podosome assembly and developmental contexts like bone and heart formation. This suggests a coherent theme of GTPase-driven cytoskeletal dynamics governing movement and tissue morphogenesis.","confidence":"High","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0061000","count":4},{"id":"GO:0007264","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0071803","count":3}]},{"hash":"1759956805190926731","title":"Actin-driven neuronal morphogenesis","description":"Most top GO terms center on actin cytoskeleton organization and dynamics (actin filament polymerization, actin cytoskeleton organization, barbed-end actin filament capping) together with neuronal morphogenesis (dendritic spine morphogenesis, neuron projection development, lamellipodium morphogenesis). This pattern points to proteins that regulate actin dynamics to shape neuronal connections and synaptic structures. A few terms related to heart development and osteoclast regulation appear but likely reflect shared cytoskeletal remodeling pathways rather than a heart- or bone-specific function.","confidence":"High","size":19,"edges":77,"triangles":96,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0071847","count":3},{"id":"GO:0070830","count":3},{"id":"GO:2001205","count":3},{"id":"GO:0051016","count":3}]},{"hash":"1968032472361673768","title":"Xenobiotic and Vitamin Transmembrane Transporters","description":"The cluster is enriched for transmembrane transport GO terms, notably xenobiotic and vitamin transport, along with diverse substrate transport such as organic cations, dehydroascorbic acid, nitrate, sialic acid, and potassium. This pattern suggests a cohort of membrane transporter proteins with broad substrate specificity, rather than a single-substrate pathway.","confidence":"High","size":19,"edges":85,"triangles":167,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":19},{"id":"GO:0035461","count":19},{"id":"GO:0042891","count":17},{"id":"GO:0071805","count":16},{"id":"GO:0042908","count":16}]},{"hash":"1925738082779837440","title":"Unknown","description":"The GO terms are diverse and do not point to a single cohesive function. While there are biosynthesis terms (biotin and antibiotic biosynthesis), many other terms are unrelated across different biological contexts, giving no clear unifying theme for the cluster.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009102","count":8},{"id":"GO:0017000","count":8},{"id":"GO:0009086","count":4},{"id":"GO:1905344","count":4},{"id":"GO:0097755","count":4}]},{"hash":"1459574298182295195","title":"Neural development signaling","description":"This cluster centers on neural development and signaling pathways, with terms like cerebellar cortex formation, Bergmann glial differentiation, and regulation of axon regeneration, plus insulin receptor signaling and growth/proliferation control. The presence of an immune-related term (T cell receptor signaling pathway) appears as an outlier or cross-talk in signaling networks, but the dominant theme is neural development and broader signal transduction.","confidence":"Medium","size":19,"edges":118,"triangles":422,"max_degree":18,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0050852","count":19},{"id":"GO:0021697","count":19},{"id":"GO:0048679","count":19},{"id":"GO:0008285","count":19},{"id":"GO:2001275","count":19}]},{"hash":"111082939010306325","title":"Embryonic development and tissue differentiation","description":"The top GO terms point to developmental processes across multiple tissues (face development, placenta development, neuron axonogenesis, cartilage growth, adipocyte differentiation) and signaling pathways (retinoic acid response). While there are a few outliers (lipopolysaccharide response, obsolete glucose regulation) the predominant theme is embryonic development and tissue-specific differentiation, suggesting these proteins function together in coordinating developmental programs.","confidence":"Medium","size":19,"edges":15,"triangles":2,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2001275","count":11},{"id":"GO:0060324","count":11},{"id":"GO:0071300","count":11},{"id":"GO:0090188","count":11},{"id":"GO:0071222","count":11}]},{"hash":"961220399994606547","title":"Neural signaling and synaptic plasticity","description":"This cluster centers on neural signaling components (calcium and potassium transport, excitatory postsynaptic potentials) and learning-related processes (long-term/medium-term memory, long-term potentiation, conditioned taste aversion), with additional links to neuropharmacology (responses to morphine, amphetamine, lithium). The common theme is how neuronal signals are translated into synaptic changes that underlie memory and learning, making the label representative of the cluster\u2019s function.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043278","count":9},{"id":"GO:0006816","count":9},{"id":"GO:0060079","count":9},{"id":"GO:0007616","count":9},{"id":"GO:0001975","count":9}]},{"hash":"1109686490780260867","title":"Ubiquitin-Proteasome Degradation & Cell Cycle Regulation","description":"These proteins are enriched for ubiquitin-dependent protein catabolic processes and polyubiquitination, including SCF-dependent proteasomal degradation, indicating a shared function in tagging substrates for destruction. The presence of cell-cycle related terms (regulation of G1/S transcription, G1 DNA damage checkpoint signaling) supports a role in cell-cycle control linked to proteolysis. Stress-related terms (cadmium response, oxidative stress-induced apoptotic signaling) suggest involvement of the proteostasis system in stress responses as well. Overall, the cluster is best described by ubiquitin-mediated protein degradation intertwined with cell-cycle regulation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0000209","count":7},{"id":"GO:0071276","count":6},{"id":"GO:0042752","count":6},{"id":"GO:1902916","count":5}]},{"hash":"19132141949345767","title":"Ubiquitin-Proteasome\u2013MHC I Antigen Presentation Pathway","description":"The terms cluster around ubiquitin-dependent protein turnover (deubiquitination, SCF-proteasome), antigen processing and presentation via MHC I, and immune signaling (T cell receptor and Fc-epsilon receptor pathways), all pointing to antigen presentation and adaptive immune activation controlled by ubiquitin-proteasome dynamics. Viral process terms support involvement in antigen processing of infected cells, while metal- and salt-stress responses are ancillary cellular stress signals. Overall, the theme is immune antigen presentation linked to ubiquitin-proteasome regulation.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":9},{"id":"GO:0010043","count":8},{"id":"GO:0002479","count":8},{"id":"GO:0010972","count":8},{"id":"GO:0050852","count":8}]},{"hash":"1135638233701604243","title":"Neural and sensory organ development","description":"The cluster is strongly enriched for terms related to neural and sensory organ formation and function, including inner ear development/morphogenesis, midbrain-hindbrain boundary development, cerebellar granule cell differentiation, facial nucleus development, and visual perception. These collectively point to coordinated development of brain regions and sensory systems (ear/eye). The one immune-related term appears peripheral to the main theme and does not override the dominant neural/sensory pattern.","confidence":"High","size":19,"edges":33,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0048839","count":13},{"id":"GO:0060021","count":9},{"id":"GO:0042472","count":9},{"id":"GO:0048706","count":9},{"id":"GO:0060272","count":9}]},{"hash":"835234150407089346","title":"Brain development and CSF/ion transport","description":"The top GO terms cluster around neural development (brain morphogenesis, pyramidal neuron development) and cerebrospinal fluid secretion, as well as various ion transport and pH-regulation processes (chloride transport, borate transport, fluid transport). This combination suggests a group of proteins tied to brain development and brain fluid/ion homeostasis, hence the label.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035641","count":2},{"id":"GO:0010036","count":2},{"id":"GO:0051453","count":2},{"id":"GO:0033326","count":2},{"id":"GO:0048854","count":2}]},{"hash":"1636586024682497821","title":"Excitatory synapse assembly and NMDA receptor regulation","description":"This cluster is dominated by GO terms for forming and organizing excitatory synapses (excitatory synapse assembly, postsynaptic membrane assembly) and modulating NMDA receptor activity, along with vesicle clustering, endocytosis, and receptor internalization. The presence of neuroblast differentiation also hints at neural development, but the strongest theme is synapse formation and function, particularly at excitatory synapses and NMDA receptor regulation.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:1904861","count":8},{"id":"GO:2000809","count":8},{"id":"GO:1900244","count":8},{"id":"GO:0051384","count":8},{"id":"GO:0097104","count":8}]},{"hash":"800547457430783178","title":"Kinase signaling and transcription regulation","description":"Based on the top GO terms, many entries relate to regulation of kinase activity (protein serine/threonine kinase activity, GTPase activity, negative regulation of protein kinase activity) and regulation of transcription by RNA polymerase II, with additional links to mRNA transport and cell cycle processes. This pattern points to a cluster of proteins involved in signaling cascades that modulate gene expression and cellular fate, rather than a single narrow function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071456","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0071902","count":3}]},{"hash":"656417567064684991","title":"Blood coagulation and extracellular matrix remodeling","description":"The top GO terms cluster around plasminogen activation, fibrinolysis, blood coagulation, ECM disassembly, and tissue remodeling, with supporting signals for fibrinolysis regulation and inflammation-related processes, indicating a cohesive theme of clotting and subsequent extracellular matrix remodeling.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0031639","count":7},{"id":"GO:0042730","count":7},{"id":"GO:0007596","count":7},{"id":"GO:0022617","count":7},{"id":"GO:0051919","count":7}]},{"hash":"2026973185730176097","title":"Unknown","description":"The top GO terms span reproduction, transcription, signaling regulation, cell-cycle control, organismal growth and development, protein quality control, nuclear transport, ribosome biogenesis, and actin nucleation. They do not cohere under a single clear function or pathway, making it hard to assign a specific, non-overlapping label.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007338","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0061099","count":3},{"id":"GO:1901976","count":3},{"id":"GO:0035264","count":3}]},{"hash":"2099284289082318637","title":"Neural ion transport and synaptic signaling","description":"These proteins are annotated with multiple GO terms linked to ion transport across membranes (potassium and sodium transport, transepithelial transport) and neural signaling (GABA pathway, EPSP, prepulse inhibition, locomotory behavior, taste aversion). This combination suggests involvement in neuronal ion handling and synaptic transmission, linking transport activity to neural signaling and related behaviors.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0055085","count":3},{"id":"GO:0070634","count":3},{"id":"GO:0001661","count":2}]},{"hash":"306255176266602179","title":"Neural and sensory development","description":"This cluster shows predominant GO terms related to nervous system and sensory organ development, including neuron migration, cerebellar granule cell differentiation, inner ear development, and synapse assembly, indicating a cohesive theme of neural and sensory development; a few terms related to immune processes are present but likely less representative.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032092","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0001764","count":3},{"id":"GO:0048839","count":3},{"id":"GO:0071639","count":3}]},{"hash":"1738098965336867907","title":"Viral genome integration and retrotransposition","description":"The GO terms cluster around proviral integration, latency establishment, DNA integration, and transposition/retrotransposition, plus related host\u2013virus entry processes and RNA-templated DNA synthesis. This points to proteins involved in viral genome integration and mobile genetic element activity. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0039651","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0046718","count":3}]},{"hash":"2081564106154171257","title":"Immune signaling and tissue morphogenesis","description":"The cluster combines strong signals from immune processes (adaptive and innate immune responses, IL-2 production regulation, cell adhesion) with pathways linked to growth factor signaling and morphogenesis (PDGF receptor signaling, Rho regulation, parathyroid gland development, mammary gland duct branching). This suggests a shared theme of immune signaling intertwined with tissue remodeling and development.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032968","count":2},{"id":"GO:0002250","count":2},{"id":"GO:1900042","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0048008","count":2}]},{"hash":"1451112418541921344","title":"Developmental signaling and adhesion","description":"GO terms emphasize regulation of signaling (phospholipase C, PI3K, Rho), cell adhesion, and various developmental processes (heart development, olfactory nerve formation, cuticle development). A few immune-related terms appear, but the unifying theme is regulated signaling during development and tissue organization.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0010863","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0061000","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0043552","count":3}]},{"hash":"681763808873801729","title":"Glycan biosynthesis and fucosylation","description":"The top GO terms are dominated by glycosylation and glycan biosynthesis processes (obsolete protein glycosylation, N-glycan fucosylation, Lewis a epitope biosynthesis, L-fucose catabolic process, glycosphingolipid biosynthetic pathway), indicating a cohesive theme around glycan assembly and modification. While a few terms touch on immune cell differentiation and neuronal migration, these are less central to the main glycan-focused annotations and may reflect broader biological contexts or annotation noise. Overall, the cluster seems to represent glycan biosynthesis and fucosylation pathways.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":6},{"id":"GO:0002361","count":5},{"id":"GO:0010493","count":5},{"id":"GO:0002522","count":5},{"id":"GO:0036071","count":5}]},{"hash":"1270333238519172478","title":"Diverse Substrate Transmembrane Transport","description":"The top GO terms show transport across membranes for a wide range of substrates (D-glucose, fucose, nitrite, nitrate, sialic acid, arabinose, potassium ions, vitamins) and even vesicular neurotransmitter loading, indicating the proteins act as transporters. Despite one obsolete term, the shared theme is membrane transport of diverse substrates, justifying a concise label that emphasizes this function.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":2},{"id":"GO:0006004","count":2},{"id":"GO:0042891","count":2},{"id":"GO:0098700","count":2},{"id":"GO:0015707","count":2}]},{"hash":"2201550101772201368","title":"Glutamatergic Synapse Signaling and Growth","description":"These proteins show a coherent emphasis on glutamatergic synaptic function, including excitatory postsynaptic potentials, glutamatergic synaptic transmission, and receptor clustering, with associated signaling events (e.g., JUN phosphorylation) that link to MAPK/NFAT pathways. Additional terms relate to growth and development (angiogenesis, multicellular organism growth), which can accompany neural signaling during development. Overall, the cluster centers on glutamatergic synapse activity with accompanying growth cues, supporting a moderate-to-high representative label. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":3},{"id":"GO:0001403","count":3},{"id":"GO:0006349","count":3},{"id":"GO:0035264","count":2},{"id":"GO:0000187","count":2}]},{"hash":"2010266903307405814","title":"Metabolic and stress signaling with ER-Golgi transport","description":"The cluster contains GO terms spanning metabolic signaling (SREBP pathway, response to nutrient) and stress/signaling responses (cellular response to hypoxia, cellular response to TGF-beta stimulus) along with a vesicular transport process (ER to Golgi). These together suggest a theme of coordinating growth/metabolism with intracellular trafficking. Some terms are obsolete or less directly connected, but the core pattern is signaling/metabolic regulation linked to secretion/trafficking, justifying a label around metabolic and stress signaling with ER-Golgi transport.","confidence":"Medium","size":18,"edges":15,"triangles":0,"max_degree":6,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0032933","count":4},{"id":"GO:0007584","count":4},{"id":"GO:0071560","count":4},{"id":"GO:0007568","count":4}]},{"hash":"1891960943045106988","title":"Isoprenoid and sterol biosynthesis","description":"The top GO terms cluster around biosynthesis of isoprenoid-derived lipids: farnesyl diphosphate biosynthesis, monoterpene biosynthesis, quinone biosynthesis, and cholesterol biosynthesis. This suggests a shared role in producing lipid-based molecules (isoprenoids and sterols) that contribute to membrane composition and electron transport cofactors. Other terms like response to cold and liver development appear less connected to this core pathway, possibly reflecting broader annotations or pleiotropy in the dataset.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009409","count":2},{"id":"GO:0001889","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0032543","count":2},{"id":"GO:0070682","count":2}]},{"hash":"1459516935775422650","title":"Glycosaminoglycan biosynthesis and sulfation","description":"The cluster is strongly enriched for proteoglycan biosynthetic processes, including keratan sulfate, heparan sulfate, and chondroitin/other sulfated GAG pathways, plus protein sulfation and related sulfation steps. This points to a cohesive theme of glycosaminoglycan assembly and sulfation in the extracellular matrix, with some ancillary metabolic terms like xenobiotic metabolism appearing but not defining the core function.","confidence":"High","size":18,"edges":91,"triangles":230,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006805","count":13},{"id":"GO:0000103","count":13},{"id":"GO:0030206","count":13},{"id":"GO:0002002","count":13},{"id":"GO:0030210","count":13}]},{"hash":"1413115612205900643","title":"Unknown","description":"The top GO terms span very different contexts (bone development, plant meristem organization, axis specification) and mix in cellular processes (receptor recycling, endosome size regulation, histone methylation, transcription regulation, and glutamatergic synaptic signaling). There is no single, cohesive function that ties these terms together, and the lack of edges suggests limited direct connectivity among the proteins. Therefore, no meaningful functional label can be assigned beyond Unknown.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000791","count":2},{"id":"GO:0009934","count":2},{"id":"GO:0060348","count":2},{"id":"GO:0007352","count":2},{"id":"GO:0035023","count":1}]},{"hash":"2052184898426562967","title":"Sumoylation-Linked Genome Maintenance","description":"The cluster centers on genome stability processes such as homologous recombination repair, meiotic chromosome alignment, and telomere maintenance, with a strong presence of protein sumoylation (autosumoylation, sumoylation). This suggests a functional module where SUMO modification regulates chromosome dynamics and DNA repair, with several additional terms indicating broader regulatory roles in development and signaling. Overall, the common thread is sumoylation-associated control of genome maintenance, despite some outlier developmental terms.","confidence":"Medium","size":18,"edges":20,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0000724","count":1},{"id":"GO:0010082","count":1},{"id":"GO:0007296","count":1},{"id":"GO:0043060","count":1}]},{"hash":"935890634068191423","title":"Unknown","description":"The GO terms are highly heterogeneous (RNA Pol III transcription and tRNA transcription, insect cuticle development, Purkinje neuron differentiation, immune signaling, cell adhesion, vitamin K response). There's no single shared function or pathway that ties most proteins together, so a specific functional label cannot be assigned.","confidence":"","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032728","count":1},{"id":"GO:0006359","count":1},{"id":"GO:0006384","count":1},{"id":"GO:0042797","count":1},{"id":"GO:0008363","count":1}]},{"hash":"855006249980964577","title":"Skeletal and cardiac muscle contraction regulation","description":"The top GO terms are all centered on muscle contraction and its regulation across muscle types (skeletal, cardiac, and smooth), including slow-twitch skeletal muscle contraction, cardiac muscle contraction, muscle filament sliding, and regulation of muscle contraction. This cohesive theme suggests proteins involved in the control and execution of muscle contraction, rather than a single pathway, making the label a precise representation of the cluster.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031444","count":5},{"id":"GO:0045932","count":4},{"id":"GO:0032780","count":4},{"id":"GO:0060048","count":4},{"id":"GO:0006940","count":4}]},{"hash":"101712537102886030","title":"Unknown","description":"The top GO terms include keratinocyte differentiation, cuticle development, larval lymph gland hemopoiesis, muscle fate, and immune responses, plus transcriptional regulation and various organ development terms from different organisms. This mix lacks a single cohesive function tying the proteins together, so a specific, representative label cannot be assigned.","confidence":"","size":18,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030216","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0008363","count":2},{"id":"GO:0001878","count":2},{"id":"GO:0032496","count":2}]},{"hash":"30191416975338036","title":"Development and Chromatin Regulation","description":"This cluster centers on proteins associated with developmental processes (larval chitin-based cuticle development; animal organ development; regulation of cell proliferation in development) and chromatin-level control (histone acetylation, histone demethylation, heterochromatin formation, transcriptional regulation). While a peripheral immune tolerance term appears, the dominant signal ties development to chromatin regulation, suggesting roles in controlling developmental gene expression programs.","confidence":"Medium","size":18,"edges":70,"triangles":101,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0061188","count":1},{"id":"GO:0048513","count":1},{"id":"GO:0043972","count":1},{"id":"GO:0002458","count":1}]},{"hash":"44391536075575274","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":141,"triangles":646,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008363","count":5},{"id":"GO:0097428","count":5},{"id":"GO:0034975","count":5},{"id":"GO:0036494","count":5},{"id":"GO:0030433","count":5}]},{"hash":"1419560149665149048","title":"Bone and Lung Development with ECM Remodeling","description":"The cluster centers on developmental processes of bone formation and lung morphogenesis, with strong signals for intramembranous ossification, bone resorption, and collagen/ basement membrane remodeling, plus epithelial branching in the lung. Supporting terms include Wnt signaling localization to the extracellular region and thyroid hormone\u2013responsive growth, all pointing to coordinated developmental signaling and extracellular matrix remodeling. An outlier term related to T cell cytotoxicity is present but does not dominate the overall theme.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0001957","count":18},{"id":"GO:0060441","count":18},{"id":"GO:0035593","count":18},{"id":"GO:0034769","count":18},{"id":"GO:0097067","count":18}]},{"hash":"2242411344948961932","title":"Mitochondrial transport and membrane dynamics","description":"This cluster is dominated by GO terms describing transmembrane transport across the mitochondrial membranes (NAD, ATP, phosphate, thiamine pyrophosphate, deoxynucleotides, magnesium ions, etc.), along with mitochondrial membrane fission and regulation of membrane permeability, as well as apoptotic mitochondrial changes. The convergence on mitochondrial transport, membrane remodeling, and apoptosis suggests a cohesive function in mitochondrial dynamics and bioenergetics.","confidence":"High","size":18,"edges":57,"triangles":70,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008637","count":14},{"id":"GO:0030974","count":14},{"id":"GO:0000002","count":14},{"id":"GO:0090149","count":14},{"id":"GO:0030302","count":14}]},{"hash":"2137625469996747311","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031442","count":2},{"id":"GO:0010390","count":2},{"id":"GO:0000184","count":2},{"id":"GO:0035206","count":1},{"id":"GO:0001711","count":1}]},{"hash":"665168029940269818","title":"Vertebrate embryonic and nervous system development","description":"This cluster is dominated by GO terms related to early embryonic processes (primitive streak formation, multicellular organism development) and nervous system/brain development (peripheral nervous system neuron development, forebrain, retina), with additional organ development terms (spleen, gonad). The combination suggests a cohesive theme around vertebrate embryogenesis and neural/organogenesis programs, rather than a single narrow function. Confidence: Medium","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0048935","count":5},{"id":"GO:0090009","count":5},{"id":"GO:0030900","count":4},{"id":"GO:0060041","count":4}]},{"hash":"1068917307650247623","title":"Plant lipid catabolism and detox response","description":"The top GO terms show a strong emphasis on triglyceride catabolic processes and other lipid-related catabolism, with supporting signals of stress/detox responses (response to toxic substance). While several terms are obsolete or diverge (e.g., biotin/methionine biosynthesis, shoot formation), the dominant theme is lipid metabolism tied to plant stress and broader metabolism, justifying a lipid-catabolism\u2013centered label with plant context.","confidence":"Medium","size":18,"edges":29,"triangles":5,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":6},{"id":"GO:0055114","count":5},{"id":"GO:0009636","count":5},{"id":"GO:0009102","count":4},{"id":"GO:1990577","count":4}]},{"hash":"835878625782612355","title":"Developmental signaling and neural patterning","description":"This cluster is enriched for neural development and patterning pathways (ROBO, SHH, axon guidance, CNS development, neuromuscular balance) and includes organogenesis terms (kidney development, ossification), suggesting a cohesive theme of developmental signaling and tissue patterning. The presence of a broad immune signaling term (T cell receptor signaling) may reflect shared signaling components rather than a primary function.","confidence":"Medium","size":18,"edges":126,"triangles":468,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0035385","count":5},{"id":"GO:0007224","count":5},{"id":"GO:0001822","count":5}]},{"hash":"1235238155456336879","title":"Synaptic Plasticity and Memory with Heart Regulation","description":"The cluster is dominated by neuronal signaling and plasticity terms (excitatory postsynaptic potential, long-term and short-term memory, long-term synaptic potentiation, calcium ion transport) and a dopaminergic/amphetamine response, pointing to memory formation and synaptic efficiency. Added heart-related terms (regulation of heart rate, heart development) suggest a cardiovascular signaling component that could intersect neural regulation. Some broad cellular housekeeping terms (NLS-bearing protein import, mitotic cell cycle) may reflect ubiquitous cellular processes rather than specific function of the cluster. Overall, the set centers on synaptic plasticity and memory with concurrent cardiac signaling involvement.","confidence":"Medium","size":18,"edges":19,"triangles":1,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0006816","count":5},{"id":"GO:0060079","count":5},{"id":"GO:0007616","count":5},{"id":"GO:0001975","count":5}]},{"hash":"746106520335782437","title":"Tissue and reproductive development","description":"Most top GO terms cluster around developmental processes across various tissues (larval cuticle, intestinal epithelium, skeletal system, roof of the mouth) and reproductive biology (ovarian follicle development, copulation, gonadotropin hormone response). A few terms also touch on vesicle transport regulation, protease activity, and immune response, suggesting a broad developmental/reproductive focus with some ancillary processes. Confidence: Medium","confidence":"Medium","size":18,"edges":46,"triangles":48,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0060628","count":1},{"id":"GO:0060576","count":1},{"id":"GO:0001501","count":1},{"id":"GO:0097211","count":1}]},{"hash":"51033916004135752","title":"Ossification and bone development signals","description":"The top GO terms are dominated by intramembranous ossification and endochondral ossification, indicating a skeletal development/ossification theme for this cluster. While there are also terms related to energy homeostasis, oxidative stress detection, and immune signaling, the strongest and most coherent signal across the terms centers on bone formation and skeletal development, justifying a bone-formation-focused label. The absence of observed edges does not undermine the functional annotation based on GO term enrichment.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000584","count":4},{"id":"GO:2000507","count":3},{"id":"GO:0033034","count":3},{"id":"GO:2000860","count":3},{"id":"GO:0001957","count":3}]},{"hash":"2236148771711915637","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061087","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0070979","count":2},{"id":"GO:2001162","count":2},{"id":"GO:0071276","count":2}]},{"hash":"2000899504730814715","title":"Immune regulation and ubiquitination","description":"Top GO terms cluster around innate immune regulation and ubiquitin-dependent signaling (negative regulation of NK cell cytotoxicity, innate immune response, regulation of IL-6 production, protein ubiquitination, and its regulation). This suggests a core theme of modulating immune signaling via ubiquitin pathways, with apoptosis as a common downstream process; other terms related to trafficking and reproduction may be incidental or reflect broader cellular roles. Overall, the strongest, cohesive signal is immune regulation linked to ubiquitination.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045953","count":2},{"id":"GO:0042147","count":2},{"id":"GO:0032715","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0031397","count":2}]},{"hash":"1354502753440581976","title":"Mitotic spindle and ciliogenesis cluster","description":"This cluster centers on mitotic control and spindle-related processes (cell division, spindle assembly in meiosis, exit from mitosis, septin ring assembly) and on ciliogenesis and cell polarity (non-motile cilium assembly, maintenance of embryonic cell shape/polarity, Hedgehog signaling via Smoothened). The combination of mitotic and ciliogenesis/polarity terms suggests a cohesive theme around cell division machinery intertwined with ciliogenesis and developmental polarity. Some terms like sperm mitochondrion organization reflect broader organelle organization in gamete contexts, but the core signal is mitotic/spindle functions linked to cilium-related development.","confidence":"Medium","size":18,"edges":3,"triangles":0,"max_degree":3,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0000921","count":7},{"id":"GO:0007224","count":7},{"id":"GO:0010458","count":7},{"id":"GO:0030382","count":7}]},{"hash":"644606743391334827","title":"Unknown","description":"The top GO terms span neural development (axonogenesis), immune signaling (T cell receptor signaling), GPCR signaling desensitization, apoptosis, synaptic plasticity regulation, and tissue morphogenesis (lung epithelium, osteoblast differentiation), indicating a highly heterogeneous set with no clear shared function. There isn\u2019t a cohesive biological theme strong enough to assign a specific label, so the cluster remains Unknown.","confidence":"","size":18,"edges":52,"triangles":49,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007409","count":18},{"id":"GO:0010898","count":18},{"id":"GO:0032092","count":18},{"id":"GO:0050852","count":18},{"id":"GO:0060968","count":18}]},{"hash":"119833937108157360","title":"Cytoskeleton remodeling during mitosis","description":"GO terms point to mitotic spindle assembly, regulation of Rho and GTPase activity, and actin cytoskeleton reorganization, all core to cytoskeletal dynamics during cell division. Additional terms on cell growth, proliferation, endocytosis, and cell spreading suggest broader links to morphogenesis and cell\u2013cell interactions, but the dominant signal centers on cytoskeletal remodeling in mitosis.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0031532","count":2},{"id":"GO:0035264","count":2}]},{"hash":"2069961399183625844","title":"Yeast-like protein processing and trafficking","description":"The cluster centers on intracellular handling and movement of proteins: ubiquitination, mRNA processing, ER exit regulation, and targeting to the cell surface, plus secretion of lysosomal enzymes. These themes align with a core role in protein processing and trafficking, complemented by growth-related cues such as pseudohyphal and invasive growth under nutrient limitation, which are characteristic of yeast/fungal responses to glucose scarcity. An outlier term related to Toll-like receptor signaling slightly lowers certainty.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0032212","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0033299","count":2},{"id":"GO:0001403","count":2}]},{"hash":"122571528158020528","title":"Vascular and ECM-driven development","description":"The top GO terms cluster around angiogenesis, collagen/ECM signaling, basement membrane and cartilage development, and overall multicellular development, indicating a shared focus on tissue formation guided by extracellular matrix and vasculature; immune-related terms appear supportive rather than central. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001525","count":4},{"id":"GO:0002250","count":3},{"id":"GO:0001502","count":3},{"id":"GO:0038063","count":3},{"id":"GO:0030216","count":3}]},{"hash":"1827229164192836679","title":"GPCR Signaling and MAPK-Rho Regulation","description":"The top GO terms center on GPCR internalization, Rho GTPase signaling and regulation, activation of GTPases, and ERK/MAPK cascade activity, with related responsiveness to prostaglandin and innate immune signaling. This points to a cohesive theme of GPCR-driven signal transduction coordinating cytoskeletal dynamics and MAPK pathways, with some broader developmental or sensory roles reflected by terms like heart development and visual perception. Overall, the proteins seem to cluster around GPCR-mediated signaling and downstream MAPK/Rho regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0051965","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0002031","count":3},{"id":"GO:0035023","count":3}]},{"hash":"2237024087127006159","title":"Neuronal differentiation and synapse maintenance","description":"The top GO terms point to neuronal development, especially cerebellar granule cell differentiation, and maintenance of synapse structure, suggesting the cluster centers on neuronal differentiation and synaptic organization. Additional terms touch on development, signaling regulation, and metabolism, but the strongest signals are neural-developmental and synaptic-related, justifying a label focused on neuron formation and synaptic maintenance.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":6},{"id":"GO:0021707","count":5},{"id":"GO:0010745","count":5},{"id":"GO:0007275","count":4},{"id":"GO:0034115","count":4}]},{"hash":"1114515470025574068","title":"Fe-S cluster assembly and central metabolism","description":"The cluster shows strong representation of iron-sulfur cluster assembly/maturation (and transfer) along with core metabolic pathways like the TCA cycle, fatty acid beta-oxidation, and biosynthesis of quinones (menaquinone and phylloquinone), indicating a theme of cofactor assembly and energy metabolism. Translation appears as a general housekeeping process, but the clearest signal is Fe-S biology linked to central metabolism.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":4},{"id":"GO:0010124","count":4},{"id":"GO:0006412","count":4},{"id":"GO:0009234","count":3},{"id":"GO:0006635","count":3}]},{"hash":"1849542091860065450","title":"Mitochondrial energy metabolism and redox balance","description":"The cluster is dominated by GO terms pointing to mitochondrial processes and redox control, including mitochondrial electron transport (NADH to ubiquinone), cell redox homeostasis, and dihydrolipoamide metabolism, along with membrane potential regulation and thiamine biosynthesis. While a few terms are obsolete or developmental, the core theme centers on mitochondrial energy production and redox regulation, suggesting these proteins function in respiration and related metabolic cofactor pathways.","confidence":"High","size":17,"edges":75,"triangles":148,"max_degree":16,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":13},{"id":"GO:0045454","count":11},{"id":"GO:0042391","count":10},{"id":"GO:0007568","count":10},{"id":"GO:0051068","count":10}]},{"hash":"587828237984501507","title":"Ribosome Biogenesis and Translation","description":"The dominant GO terms are ribosome biogenesis (GO:0042254) and ribosomal subunit biogenesis (GO:0042274) along with cytoplasmic translation (GO:0002181) and tRNA modification (GO:0006400), pointing to a core ribosome assembly and protein-synthesis function. Additional terms for cell cycle, cell division, and cell septum assembly suggest coordination of growth with division. Stress-related terms (positive regulation of cellular response to amino acid starvation, negative regulation of response to salt stress) indicate links to nutrient status that commonly regulate ribosome production. Taken together, this cluster likely represents a ribosome-biogenesis/translation module with growth-division coupling.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0090529","count":3},{"id":"GO:0000747","count":3},{"id":"GO:0042274","count":3},{"id":"GO:0007049","count":3}]},{"hash":"335786790083985781","title":"Developmental ECM Remodeling and Cell Migration","description":"The top GO terms cluster around extracellular matrix remodeling (collagen catabolic process, ossification, cuticle development) and cell movement (leukocyte and keratinocyte migration), with supporting notes on vascular remodeling and immune cell regulation. This suggests a broad theme of tissue morphogenesis and migratory processes rather than a single specific pathway, so a label focused on ECM remodeling and cell migration during development seems representative.","confidence":"Medium","size":17,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":7},{"id":"GO:0030574","count":2},{"id":"GO:1904707","count":1},{"id":"GO:0050900","count":1},{"id":"GO:1900122","count":1}]},{"hash":"467592318890237920","title":"RNA Pol II Transcription Regulation","description":"This cluster is dominated by GO terms for transcription by RNA polymerase II and its regulation (DNA-templated transcription and negative regulation of transcription by Pol II), suggesting a core role in transcriptional control. The presence of embryonic eye morphogenesis and semicircular canal morphogenesis terms indicates potential involvement in developmental processes, possibly linking transcriptional regulators to organogenesis in the eye and inner ear. Some obsolete terms reflect older annotations but do not negate the main transcription-centric theme.","confidence":"Medium","size":17,"edges":55,"triangles":79,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0048752","count":6},{"id":"GO:0036091","count":5},{"id":"GO:0000122","count":5}]},{"hash":"939011813611297218","title":"Unknown","description":"Insufficient GO term signals to identify a shared function for this 17-protein cluster; no top GO terms are provided to define a common theme, so a meaningful label cannot be assigned. The available network metrics (edges/triangles) do not by themselves imply a specific biological role.","confidence":"","size":17,"edges":130,"triangles":598,"max_degree":16,"top_function":null,"top_go_terms":[]},{"hash":"1448491664274851125","title":"Cardiac and visual GPCR-cAMP signaling","description":"These proteins appear linked by GPCR-cAMP signaling pathways that operate in both the nervous system and heart, with a focus on vision-related signaling (visual perception, opsin signaling) and neural plasticity (long-term potentiation), as well as regulators of heart contraction. The presence of adenylate cyclase activation, cAMP signaling, and protein phosphorylation supports a cohesive theme of GPCR-mediated signal transduction affecting both neural and cardiac tissues.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":6},{"id":"GO:0060291","count":6},{"id":"GO:0001975","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0098735","count":5}]},{"hash":"1056561706044706398","title":"Developmental Proteostasis and Stress Signaling","description":"The cluster shows enrichment for proteasome-regulated protein catabolism (both negative and positive regulation), ribosome biogenesis, DNA replication and transcription-coupled nucleotide-excision repair, and development/stress-related signaling (JNK cascade, response to wounding, apoptotic regulation, cerebellar cortex development, cranial skeleton morphogenesis). This suggests a cohesive theme where proteostasis and protein synthesis intersect with DNA maintenance and developmental signaling under stress. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0032435","count":3},{"id":"GO:0021695","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0009611","count":3},{"id":"GO:0006283","count":3}]},{"hash":"54420532486743583","title":"T cell signaling and lymphoid differentiation","description":"The top GO terms are dominated by T cell receptor signaling, activated T cell proliferation, NK T cell differentiation, B cell differentiation, and hemopoiesis, with KIT signaling and general hematopoietic terms also present, indicating a cluster enriched for lymphoid immune signaling and development. Some neural development terms may reflect annotation cross-talk rather than core function, but the dominant theme is immune cell signaling and differentiation.","confidence":"High","size":17,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031532","count":16},{"id":"GO:0007409","count":16},{"id":"GO:0050852","count":16},{"id":"GO:1900086","count":16},{"id":"GO:0021697","count":16}]},{"hash":"1759051548260126309","title":"Protein homeostasis and trafficking","description":"The GO terms point to ubiquitin-dependent protein degradation (ERAD), autophagy, and protein transport/trafficking (ER to Golgi, peroxisome import), along with oxidative stress responses, suggesting a theme of protein quality control and intracellular handling rather than a single enzymatic function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0016558","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0051260","count":2}]},{"hash":"2271467105452264854","title":"Spinal NMDA Receptor\u2013Mediated Synaptic Development","description":"The cluster is enriched with terms for NMDA receptor clustering and activity regulation, reelin-mediated signaling, excitatory postsynaptic potential potentiation, and ventral spinal cord development, plus synapse localization. Together these point to NMDA-receptor\u2013driven synaptic signaling and maturation in the spinal cord during development, with associated patterning and excitatory transmission changes.","confidence":"High","size":17,"edges":22,"triangles":4,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0038026","count":4},{"id":"GO:0048265","count":3},{"id":"GO:0097114","count":3},{"id":"GO:0021517","count":3},{"id":"GO:2000310","count":3}]},{"hash":"2109941542676132400","title":"Embryonic organogenesis and transcription regulation","description":"The top GO terms cluster around developmental processes across multiple organs (eye/retina, lung, bone, muscle) combined with transcriptional regulation by RNA polymerase II, suggesting coordinated embryonic morphogenesis driven by transcription control. Eye-related terms are particularly prominent, but the breadth points to general organogenesis. ","confidence":"High","size":17,"edges":93,"triangles":215,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0048048","count":7},{"id":"GO:0060041","count":6},{"id":"GO:0002076","count":6},{"id":"GO:0043010","count":6}]},{"hash":"907888474585062468","title":"Biogenic Amine and Neurotransmitter Biosynthesis","description":"The top GO terms cluster around biosynthesis of multiple biogenic amines and amino-acid\u2013derived neurotransmitters (histamine, dopamine, serotonin, GABA, taurine, and glutamate catabolism) along with general metabolic context (TCA cycle, pH regulation) and stimulus responses. This points to a cohesive functional theme of amino-acid\u2013derived neurotransmitter production and related metabolism, rather than disparate pathways.","confidence":"High","size":17,"edges":85,"triangles":178,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":4},{"id":"GO:0001694","count":4},{"id":"GO:0006585","count":4},{"id":"GO:0051454","count":4},{"id":"GO:0042412","count":4}]},{"hash":"217322228859601780","title":"Transcription and Cell Cycle Checkpoint Regulators","description":"The cluster is dominated by DNA-templated transcription and G1/S transition/mitotic checkpoint signaling terms, suggesting a cohesive group of proteins coordinating transcriptional control during the cell cycle. Additional terms for cell division, ER stress, and various differentiation processes imply some broader regulatory connections, but the core theme remains transcriptional regulation linked to cell cycle checkpoints.","confidence":"High","size":17,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0000083","count":7},{"id":"GO:0031571","count":6},{"id":"GO:0071276","count":6},{"id":"GO:0051301","count":5}]},{"hash":"1370653308156274635","title":"Hair follicle development and skin immune signaling","description":"Proteins in this cluster show a combination of skin/hair development signals (hair follicle morphogenesis; bone development; response to vitamin D) and immune-related pathways (adaptive and innate immune responses; T cell receptor signaling). They also feature regulatory signaling and post-translational control (regulation of JNK cascade; small GTPase signaling; ubiquitination), suggesting a coordinated module linking skin development with immune and stress-response signaling. ","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0048265","count":2},{"id":"GO:0060348","count":2},{"id":"GO:0031069","count":2},{"id":"GO:0002250","count":2}]},{"hash":"2024240087770918114","title":"CDK and MAPK pathway regulators","description":"This cluster centers on regulation of kinase activity and mitotic progression, highlighted by GO terms for the cell cycle, negative regulation of cyclin-dependent kinases, and modulation of ERK/MAPK signaling, with additional hints from protein tyrosine dephosphorylation and broader signaling roles in neural and immune contexts. The core theme is coordinated control of kinase-driven signaling during cell division and growth.","confidence":"High","size":17,"edges":24,"triangles":12,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034501","count":8},{"id":"GO:0045736","count":8},{"id":"GO:0007049","count":8},{"id":"GO:0070373","count":6},{"id":"GO:0000200","count":6}]},{"hash":"330440786433601359","title":"Developmental transcription and tissue formation","description":"These proteins show enrichment for DNA-templated transcription and histone methylation (epigenetic regulation) alongside developmental processes such as skin development, intramembranous ossification, and cartilage condensation. The combination suggests a cluster of factors involved in developmental gene regulation and tissue differentiation, with some components related to transcription complex assembly. Overall, the label reflects the predominant theme of developmental regulation of gene expression and tissue formation rather than a single narrowly defined function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0070208","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0034729","count":3},{"id":"GO:0048668","count":3}]},{"hash":"731243236789032806","title":"Growth signaling and cytoskeletal regulation","description":"The top GO terms point to cellular processes that govern growth and division (multicellular organism growth, mitotic cell cycle, regulation of cell cycle checkpoint) and signaling via tyrosine phosphorylation (positive regulation of peptidyl-tyrosine phosphorylation, negative regulation of protein tyrosine kinase activity), plus cytoskeletal remodeling (positive regulation of Arp2/3 complex\u2013mediated actin nucleation) and related stress responses (cellular response to hypoxia, defense response). While immune-related and stress-related terms appear, the cohesive theme appears to be a module coordinating growth, signaling, and cytoskeletal dynamics in a cell, with ancillary regulatory and stress-response components. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035264","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0071456","count":5},{"id":"GO:0050731","count":5},{"id":"GO:0051028","count":5}]},{"hash":"460633292346348620","title":"Hepatic coagulation and regeneration","description":"The top GO terms are dominated by liver-related processes: blood coagulation, fibrinolysis, hepatocyte proliferation, and liver regeneration, along with extracellular matrix component secretion and xenobiotic response. Although one term mentions Purkinje cell differentiation, the majority of terms point to hepatic hemostasis, tissue remodeling, and metabolic response, supporting a label of hepatic coagulation and regeneration.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":3},{"id":"GO:0042730","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0035609","count":2},{"id":"GO:2000346","count":2}]},{"hash":"1875750330404549002","title":"Plant cell wall glycoprotein biosynthesis and AGP glycosylation","description":"The top GO terms cluster around arabinogalactan protein metabolism, hydroxyproline O-glycosylation, and other glycan biosynthesis processes, plus plant-relevant development like root hair formation and seed coat mucilage. Some terms (e.g., insect ovary structures) may reflect cross-species annotations but do not override the prevailing plant glycoprotein/glycosylation theme. Overall, the cluster appears to represent plant cell wall glycoprotein biosynthesis and AGP glycosylation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":3},{"id":"GO:0080147","count":3},{"id":"GO:0010405","count":3},{"id":"GO:0001744","count":3},{"id":"GO:0010493","count":3}]},{"hash":"2267836764089536831","title":"B cell receptor signaling and adaptive immunity","description":"The cluster is dominated by GO terms tied to B cell biology, including B cell receptor signaling and adaptive immune response, plus positive regulation of B cell proliferation, which collectively point to B cell activation and immune signaling. Additional terms referencing cytoskeleton/membrane organization (microspike assembly, caveola assembly) align with cellular processes involved in immune synapse formation and vesicle trafficking, supporting a cohesive theme around B cell signaling, with some noise from unrelated or obsolete terms. ","confidence":"Medium","size":17,"edges":23,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:1990441","count":2},{"id":"GO:0001878","count":2},{"id":"GO:0016191","count":2},{"id":"GO:0030890","count":2},{"id":"GO:0050853","count":2}]},{"hash":"2303735167428611102","title":"Muscle development and calcium signaling","description":"The cluster most strongly features terms related to skeletal muscle fiber development and calcium signaling (e.g., calcium release channel activity regulation, postsynaptic calcium concentration), suggesting proteins involved in muscle differentiation and excitation-contraction coupling. A few terms point to other tissues (Schwann cell, lung differentiation), making the theme less uniform, but the dominant signal is muscle-related.","confidence":"Medium","size":17,"edges":16,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":4},{"id":"GO:0016310","count":2},{"id":"GO:0051343","count":2},{"id":"GO:0032516","count":2},{"id":"GO:0060316","count":2}]},{"hash":"321643465595599101","title":"Immune Activation and ECM Remodeling","description":"The cluster shows enrichment for immune-related processes (complement activation, leukocyte migration, CD4+ regulatory T cell differentiation) together with extracellular matrix disassembly, suggesting a role in immune response modulation linked to tissue remodeling. Glycosylation-related terms (fucosylation, Lewis antigen biosynthesis) also align with immune cell interactions, while a couple of terms (sensory perception of smell, obsolete annotations) may be noise. Overall, it points to immune activation intertwined with ECM remodeling.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007608","count":2},{"id":"GO:0070584","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0022617","count":2},{"id":"GO:0002361","count":2}]},{"hash":"43206352591340801","title":"Vertebrate embryonic organ and tissue morphogenesis","description":"This cluster centers on developmental processes across multiple vertebrate tissues and organs (palate, heart, skeletal muscle, hindlimb, eye, brain regions, prostate, gonads). The inclusion of myoblast proliferation and skeletal muscle development alongside diverse organ morphogenesis suggests a general embryonic morphogenesis theme rather than a single tissue-specific pathway.","confidence":"High","size":17,"edges":30,"triangles":3,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":7},{"id":"GO:0007507","count":7},{"id":"GO:2000288","count":6},{"id":"GO:0021986","count":6},{"id":"GO:0035116","count":6}]},{"hash":"513487202024890931","title":"Embryonic development and tissue morphogenesis","description":"This cluster's terms cluster around embryonic organ development and tissue shaping, including regulation of DNA-templated transcription; pancreas development; left-right pattern formation; palate/roof of mouth development; placenta-related processes; cartilage morphogenesis; trophoblast differentiation; and epithelial-to-mesenchymal transition in heart structures. The common theme is embryonic development and morphogenesis across multiple tissues, rather than a single, narrow pathway.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0003323","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0035270","count":2}]},{"hash":"1437459505905313762","title":"Ubiquitin-Dependent Proteolysis","description":"Top GO terms cluster around ubiquitin-dependent protein turnover, including ubiquitin-dependent proteolysis, autoubiquitination, and K48- and K6-linked ubiquitination (ERAD and histone turnover also appear). This points to a functional group of proteins involved in tagging substrates for proteasomal degradation and regulating signaling pathways through controlled degradation, such as Wnt and TNF pathways.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0051865","count":5},{"id":"GO:0070936","count":5},{"id":"GO:0085020","count":4},{"id":"GO:0030433","count":4}]},{"hash":"2118400977412474660","title":"Ubiquitin-Dependent Proteolysis and Signaling","description":"Proteins here are dominated by GO terms for ubiquitin-dependent protein degradation and various ubiquitin linkages (K6, K48, K63), plus histone ubiquitination and autoubiquitination, pointing to roles in targeted proteolysis. The presence of terms related to regulation of JNK cascade and NF-kappaB signaling (I\u03baB phosphorylation) suggests these proteins participate in ubiquitin-mediated modulation of key signaling pathways and chromatin turnover, including ERAD-associated degradation. Overall, the cluster reflects ubiquitin-driven proteolysis coupled with signaling regulation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:1903265","count":7},{"id":"GO:0051865","count":6},{"id":"GO:0085020","count":6},{"id":"GO:0070936","count":6}]},{"hash":"1476316714799744992","title":"Synaptic Plasticity and Immune Signaling Regulators","description":"This cluster is dominated by neuronal plasticity terms (long-term/short-term synaptic plasticity and potentiation) but also includes immune signaling terms (adaptive immune response, defense against virus, T cell homeostasis, IL-17 signaling) and ubiquitination-related regulation, suggesting proteins that coordinate synaptic function with immune signaling pathways.","confidence":"Medium","size":17,"edges":25,"triangles":5,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0048169","count":2},{"id":"GO:0048172","count":2},{"id":"GO:1900273","count":2},{"id":"GO:1901224","count":1},{"id":"GO:0043029","count":1}]},{"hash":"1123611171317536908","title":"Developmental transcriptional regulation","description":"These proteins show GO terms tied to embryonic development across multiple organs (midbrain, habenula, hindlimb, eye, heart, gonads, prostate) and a shared theme of transcriptional control (including negative regulation of RNA polymerase II). The unifying function appears to be regulation of gene expression during development rather than a single tissue-specific process, justifying the label Developmental transcriptional regulation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0030901","count":5},{"id":"GO:2000288","count":4},{"id":"GO:0021986","count":4},{"id":"GO:0035116","count":4}]},{"hash":"1556836907779324930","title":"Growth and cell cycle regulation","description":"This cluster centers on growth signaling and transcriptional control, with terms like cellular response to TGF-beta, DNA-templated transcription, cell division, and regulation of the cell cycle checkpoint. While there are a few developmental terms (fertilization, endothelial chemotaxis), the dominant theme is growth/proliferation coupled with transcriptional regulation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071560","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007338","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0035767","count":2}]},{"hash":"965325281300660303","title":"Complement-Coagulation and Tissue Remodeling","description":"This cluster is dominated by immune/hemostasis processes: complement activation (classical and lectin), blood coagulation, and catabolic remodeling of collagen and elastin, with accompanying leukocyte recruitment and proliferation signaling. These terms point to an integrated module linking innate immunity and coagulation with extracellular matrix remodeling, despite some broader signals like Wnt and cell proliferation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":9},{"id":"GO:0007596","count":8},{"id":"GO:0016055","count":7},{"id":"GO:0030574","count":7},{"id":"GO:0001867","count":7}]},{"hash":"2302892235478720283","title":"GPCR Signaling Regulation and Development","description":"This cluster is enriched for GPCR-related processes (GPCR internalization, desensitization, tachykinin receptor signaling) and accompanying signaling activities (GTPase activity regulation, phospho-threonine events), with additional signals pointing to developmental differentiation in heart, neurons, and adipocytes. These collectively suggest a theme of GPCR-mediated signaling control across diverse developmental contexts.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0021707","count":3},{"id":"GO:0002031","count":2},{"id":"GO:0007217","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1078704327243227464","title":"Collagen-RTK Signaling in Cartilage Development","description":"Top GO terms point to collagen-activated RTK signaling (GO:0033138), ERK cascade (GO:0070371), cartilage condensation (GO:0001502), receptor clustering, cell adhesion, and angiogenesis (GO:0001525). This suggests a module where collagen interfaces trigger tyrosine kinase receptors, activating ERK signaling to coordinate cartilage formation and vascularization, with remodeling-related apoptosis terms. Overall, a cohesive theme of collagen-driven signaling promoting cartilage development.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":3},{"id":"GO:0043065","count":3},{"id":"GO:0070371","count":3},{"id":"GO:0043113","count":3},{"id":"GO:0038063","count":3}]},{"hash":"1586428933495925046","title":"Unknown","description":"The top GO terms span diverse processes\u2014from protein complex assembly (homooligomerization, heterotrimerization) to mitotic cell cycle, cell division, neuronal development (synapse and dendrite morphogenesis, eye morphogenesis), mRNA splicing, hypoxia response, and kinase activity regulation. Because there is no single cohesive function linking these terms, the proteins likely form a heterogeneous set rather than a coherent biological module.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051260","count":4},{"id":"GO:0070208","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0051965","count":3},{"id":"GO:0048593","count":3}]},{"hash":"737893511475247524","title":"Fe-S cluster biogenesis and cofactor biosynthesis","description":"The set centers on Fe-S cluster assembly and iron incorporation into metallo-sulfur clusters, with multiple biosynthetic terms for vitamins and cofactors (biotin, pyridoxine, quinolinate) also enriched. This points to a cohesive theme around metal cofactor biogenesis and related metabolic pathways, with transcriptional activity present but not defining the core function. Thus, labeling this cluster as Fe-S cluster biogenesis and cofactor biosynthesis best reflects the shared biology.","confidence":"Medium","size":16,"edges":11,"triangles":1,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0009102","count":3},{"id":"GO:0008615","count":3},{"id":"GO:0051384","count":3},{"id":"GO:0018283","count":3}]},{"hash":"1128071801103627602","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":12,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030260","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0071031","count":2}]},{"hash":"2189600261128603884","title":"RNA Processing and Translational Regulation","description":"This cluster is dominated by GO terms tied to translation (initiation, translation, termination, cytoplasmic translation, translational fidelity) and RNA processing (spliceosomal tri-snRNP complex assembly). The cluster appears to center on RNA metabolism and control of protein synthesis, with antibiotic response likely linked to translation inhibition. Some terms (hematopoietic differentiation, skeletal muscle contraction) are less directly connected and may reflect broader roles of the proteins. Overall, the pattern supports a function in RNA processing and translation regulation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006413","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0045903","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0000244","count":2}]},{"hash":"2196704617800810688","title":"Cell signaling and autophagy regulators","description":"The GO terms point to proteins involved in multiple signaling pathways (NF-kappaB, ERK, Hippo, Rho) and cellular stress processes (macroautophagy, wound healing), plus developmental contexts. This suggests a theme of regulating signaling and autophagy/stress responses rather than a single pathway or function, so a broad label like \u201ccell signaling and autophagy regulators\u201d fits best.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016236","count":2},{"id":"GO:0043124","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0070374","count":2}]},{"hash":"1025788827932455697","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":14,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0061408","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0009910","count":1}]},{"hash":"2074815861343650895","title":"Hormone-regulated cell cycle and metabolism","description":"The dominant term is positive regulation of G1/S transition, with multiple metabolism-related terms (androgen metabolism, fatty acid omega-oxidation, xenobiotic/vitamin D catabolism, methylation) and tissue-context terms (prostate growth, endothelial adhesion). This suggests a cluster of proteins involved in hormone signaling that links cell cycle control to metabolic and xenobiotic processing, potentially in prostate and vascular contexts.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1900087","count":9},{"id":"GO:0008209","count":8},{"id":"GO:0035865","count":8},{"id":"GO:0010430","count":8},{"id":"GO:0060736","count":8}]},{"hash":"1167268982212163879","title":"Steroid hormone and pigment biosynthesis","description":"The top GO terms cluster around production and metabolism of steroid hormones (androgen metabolism and glucocorticoid biosynthesis) and pigment/retinoid pathways (retinal metabolism, melanin biosynthesis). Additional terms for tetrahydrobiopterin biosynthesis and fatty acid elongation point to broader metabolic biosynthesis, supporting a cohesive theme of steroid and pigment biosynthesis; some terms like antibiotic response may be peripheral noise. ","confidence":"Medium","size":16,"edges":28,"triangles":15,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0046677","count":5},{"id":"GO:0010815","count":4},{"id":"GO:0008209","count":4},{"id":"GO:0006710","count":4},{"id":"GO:0006729","count":4}]},{"hash":"1411074210805601669","title":"RNA processing and RNA silencing machinery","description":"The cluster is dominated by GO terms tied to RNA maturation and regulation of gene expression at the post-transcriptional level, including translation, rRNA and tRNA processing, RNA editing, and siRNA/miRNA processing plus mRNA silencing. This points to a coherent theme of RNA metabolism and RNA interference pathways; a few unrelated terms (like dosage compensation and a development morphogenesis term) may reflect broader regulatory roles or annotation noise, but the primary signal is RNA processing and silencing machinery.","confidence":"High","size":16,"edges":118,"triangles":533,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0006364","count":6},{"id":"GO:0045433","count":5},{"id":"GO:0006382","count":5},{"id":"GO:0008033","count":5}]},{"hash":"1742711730441902636","title":"ECM remodeling and enamel formation","description":"This cluster is dominated by GO terms for extracellular matrix disassembly, collagen and elastin catabolic processes, and amelogenesis (enamel formation), pointing to connective tissue remodeling and tooth enamel development. Additional terms on cell proliferation regulation and immune interactions exist but the strongest signal centers on ECM turnover and enamel formation, with a few transcription-related terms that may reflect annotation noise or multifunctional proteins.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0045944","count":7},{"id":"GO:0097186","count":7},{"id":"GO:0030574","count":7},{"id":"GO:0022617","count":7}]},{"hash":"1520665819126842869","title":"Developmental signaling and tissue differentiation","description":"The proteins show enrichment across multiple development- and signaling-related GO terms spanning retina/visual perception, nervous system development, muscle and keratinocyte differentiation, and signaling pathways (Wnt, Hippo) with associated processes like apoptosis and cell cycle. This suggests a unifying theme of signaling guiding tissue differentiation across diverse tissues, rather than a single specialized function.","confidence":"High","size":16,"edges":38,"triangles":33,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":15},{"id":"GO:0000278","count":15},{"id":"GO:0007519","count":13},{"id":"GO:0050853","count":13},{"id":"GO:0007399","count":13}]},{"hash":"1950338482596000828","title":"Neural development and SHH/ROBO signaling","description":"These terms cluster around nervous system development (nervous system development, hippocampus development) and signaling pathways known to guide neural patterning, such as Sonic hedgehog (smoothened pathway) and Roundabout (ROBO) signaling, with ERK cascade involvement and cell proliferation signals. While kidney development appears, the strongest, repeatedly represented themes are neural development and developmental signaling, indicating a coherent neural-development-focused cluster.","confidence":"High","size":16,"edges":39,"triangles":15,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001822","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0043525","count":4},{"id":"GO:0021766","count":4}]},{"hash":"1876999496152225101","title":"Unknown","description":"The Top Terms are scattered across diverse biological processes (heart and Schwann cell development, multicellular organism development, visual perception, abscisic acid signaling, T cell receptor signaling, cell cycle progression, and kinase/phosphatase regulation), with no clear single theme or dominant pathway linking them. This suggests a heterogeneous cluster without a coherent, interpretable function, so Unknown is the most appropriate label. ","confidence":"","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":7},{"id":"GO:0007275","count":6},{"id":"GO:0032516","count":5},{"id":"GO:0045163","count":5},{"id":"GO:0014044","count":5}]},{"hash":"261440710953934648","title":"Membrane Transport of Ions and Nutrients","description":"The top GO terms are dominated by membrane transport of a variety of small solutes and ions (e.g., sodium-dependent organic cation transport, nitrate and potassium transmembrane transport, sialic acid and selenite transport, dehydroascorbic acid transport) and related ascorbate metabolism, suggesting a cluster of transporter proteins handling nutrients and redox-active compounds. Some regulatory terms are present but the primary pattern is transport across membranes.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045429","count":3},{"id":"GO:0008285","count":3},{"id":"GO:0043524","count":2},{"id":"GO:0019852","count":2},{"id":"GO:0070715","count":2}]},{"hash":"139482660068606050","title":"Rho/Rac/Ras GTPase Signaling and Cell Migration","description":"The cluster is dominated by GO terms for small GTPase\u2013mediated signaling and regulation of Rac/Rho pathways, along with processes like cell migration, adhesion, and cytoskeletal dynamics. Additional terms link to immune functions (innate response, B cell maturation) and apoptosis, suggesting a cohesive theme of dynamic GTPase signaling governing movement, signaling, and immune context, rather than a single enzyme activity.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0035020","count":2},{"id":"GO:0002344","count":2}]},{"hash":"1175368355651187646","title":"Glycinergic Synaptic Transmission and Ion Transport","description":"The top GO terms center on glycinergic synaptic transmission and its regulation, along with transmembrane transport of potassium and sodium, indicating a theme of inhibitory synaptic signaling coupled with membrane ion flux in neurons. Auditory-related terms (sensory perception of sound) and thalamus development further support a neural, possibly auditory-processing context. The combination of these terms suggests a cohesive function in glycinergic inhibitory signaling and neuronal ion transport.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060012","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0007605","count":2}]},{"hash":"1758581688552377939","title":"Complement signaling and immune cell adhesion","description":"The top GO terms cluster around immune-related processes: complement activation (classical pathway), complement receptor\u2013mediated signaling, and viral suppression of complement activation, paired with immune regulation (T cell homeostasis, myeloid cell apoptotic regulation) and coagulation. There are also adhesion-related terms (cell-matrix and heterophilic cell\u2013cell adhesion), which fit with immune cell interactions. An outlier term for photosynthesis likely reflects annotation noise. Overall, the cluster seems centered on complement-mediated immune signaling and cell adhesion. ","confidence":"Medium","size":16,"edges":16,"triangles":1,"max_degree":4,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0007160","count":4},{"id":"GO:0015979","count":4},{"id":"GO:0002430","count":3},{"id":"GO:0039573","count":3},{"id":"GO:2001241","count":3}]},{"hash":"1421081944372941407","title":"Glycosaminoglycan biosynthesis","description":"The top GO terms are strongly centered on proteoglycan and glycosaminoglycan biosynthesis, including keratan sulfate, heparan/heparin proteoglycan, and related sulfated proteoglycans, suggesting a cohesive biosynthetic role for these proteins. Some other terms appear unrelated or obsolete, and there are no observed interactions, but the dominant theme points to GAG/proteoglycan assembly. Confidence in this label is High.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":2},{"id":"GO:0006805","count":1},{"id":"GO:0000103","count":1},{"id":"GO:0030206","count":1},{"id":"GO:0002002","count":1}]},{"hash":"470452248279140830","title":"Unknown","description":"The top GO terms cover a wide range of unrelated processes (stress responses to xenobiotics, hypoxia, estradiol; inflammatory signaling; basic metabolism; DNA replication and cell cycle). With no clear shared function linking the proteins and no edges connecting them, there isn\u2019t a coherent theme to label; therefore Unknown.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0032355","count":2},{"id":"GO:0006032","count":1},{"id":"GO:0002532","count":1}]},{"hash":"628397380323545120","title":"Blood coagulation and inflammatory signaling","description":"The cluster is dominated by GO terms tied to coagulation, complement activation, and inflammatory mediator production (IL-8, nitric oxide), plus platelet regulation and HOCl synthesis, along with a general protein secretion signal. A couple of terms (brown fat differentiation, negative regulation of gluconeogenesis) appear but are less central to the core theme.","confidence":"Medium","size":16,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":7},{"id":"GO:0050873","count":6},{"id":"GO:0032757","count":4},{"id":"GO:0045721","count":4},{"id":"GO:0045429","count":4}]},{"hash":"635440457068918474","title":"Chromatin remodeling and transcription regulation","description":"The proteins in this cluster are strongly associated with transcription control (DNA-templated transcription, RNA polymerase II\u2013mediated regulation) and chromatin-related processes (nucleosome assembly, histone modification). Although some terms are outdated, the core signal points to gene-expression regulation through chromatin state and transcription machinery, with supportive links to protein turnover pathways that can modulate transcription factors. Overall, the dominant theme is chromatin-level transcription regulation.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0051092","count":2},{"id":"GO:1905050","count":2},{"id":"GO:0032436","count":2}]},{"hash":"365035337787776144","title":"Neural development and innate immune signaling","description":"This cluster shows strong neural development signals (axonogenesis, corpus callosum development, and synapse assembly) along with innate immune pathways (innate immune response, interferon-beta production, dsRNA response, and LPS signaling), suggesting a neurodevelopment context with neuroimmune interactions. Collagen fibril organization is also present, indicating extracellular matrix remodeling during development.","confidence":"Medium","size":16,"edges":15,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0030199","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0007409","count":3}]},{"hash":"401537495158827731","title":"Glycoprotein and plant cell wall biosynthesis","description":"The top GO terms cluster around glycosylation and glycoprotein metabolism (O-linked glycosylation via hydroxyproline, arabinogalactan protein metabolism, poly-N-acetyllactosamine biosynthesis) and plant cell wall\u2013related biosynthetic processes (root hair development, seed coat mucilage biosynthesis). Together they suggest a cohesive function in building and modifying glycoproteins and cell wall polysaccharides, with related cell surface interactions and polarity terms supporting this theme.","confidence":"High","size":16,"edges":20,"triangles":5,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":8},{"id":"GO:0010493","count":8},{"id":"GO:0001744","count":8},{"id":"GO:0030311","count":8},{"id":"GO:0042248","count":8}]},{"hash":"813366238184997508","title":"Translation Initiation and mRNA Capping","description":"The cluster\u2019s top GO terms cluster around translation initiation (regulation of translational initiation, formation of preinitiation complex, viral termination-reinitiation) and RNA processing steps like 7-methylguanosine mRNA capping and tRNA methylation, suggesting a core theme of translation control and RNA modification. Some lipid biosynthesis and methylation terms are present but appear less central to the core function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075525","count":2},{"id":"GO:0006446","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0043985","count":2}]},{"hash":"1361872085507804213","title":"Neural development and synapse assembly","description":"The set includes terms like positive regulation of synapse assembly, clustering of voltage-gated sodium channels, and cell adhesion, which point to neural development and synaptic organization as the core theme. Embryonic morphogenesis and multicellular development terms support a broader developmental context, while complement activation appears less central. Confident that the neural/synaptic pattern best describes the cluster, with some incidental immune signals.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0048671","count":2},{"id":"GO:0071639","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0006508","count":2}]},{"hash":"938505777954098366","title":"Ubiquitin-Mediated Proteolysis and ERAD","description":"The top GO terms are dominated by ubiquitination pathways (K48-linked, K63-linked, polyubiquitination) and ubiquitin-dependent protein catabolic processes, including autoubiquitination and ERAD. This points to a cluster of proteins involved in tagging and degrading proteins, quality control, and related apoptotic signaling, with a peripheral note on peroxisome matrix import that can involve ubiquitin-related receptor cycling. Overall, the cluster represents components of the ubiquitin-proteasome system and ER-associated degradation.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070936","count":5},{"id":"GO:0042787","count":5},{"id":"GO:0006915","count":4},{"id":"GO:0070534","count":4},{"id":"GO:0051026","count":4}]},{"hash":"922974698911236744","title":"Ubiquitin-dependent proteolysis and chromatin regulation","description":"This cluster is enriched for ubiquitin-related processes (ubiquitin-dependent protein catabolic process, protein autoubiquitination) and histone-related catabolic/modification processes, plus regulation of signaling pathways (JNK, I-kappaB, TNF). The common thread is proteostasis via ubiquitination and transcriptional/chromatin-level control of signaling responses.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0009048","count":3},{"id":"GO:0036205","count":3},{"id":"GO:1903265","count":3},{"id":"GO:2000620","count":3}]},{"hash":"415361543630353835","title":"Bacterial cell-surface polysaccharide biosynthesis","description":"The Top Terms are dominated by biosynthetic pathways for surface polysaccharides (lipopolysaccharide, O-antigen, colanic acid), along with related sugar metabolism (dTDP-rhamnose, galactose) and a storage polymer (poly-hydroxybutyrate). This points to a cohesive module of enzymes dedicated to constructing bacterial outer-murface components and associated polysaccharides, rather than core metabolic or signaling roles. Some terms (e.g., antibiotic biosynthesis, androgen metabolism) appear incidental, but the dominant pattern supports a surface polysaccharide biosynthesis theme.","confidence":"High","size":16,"edges":3,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0042619","count":6},{"id":"GO:0097171","count":5},{"id":"GO:0009103","count":5},{"id":"GO:0019305","count":5}]},{"hash":"2036009841762623394","title":"Presynaptic vesicle docking and exocytosis","description":"This cluster is dominated by GO terms describing presynaptic vesicle handling and neurotransmitter release, including synaptic vesicle maturation, dense core vesicle exocytosis, vesicle docking, and long-term synaptic depression. Regulation of GTPase activity also aligns with vesicle trafficking control, supporting a cohesive function in presynaptic neurotransmission and plasticity.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0060292","count":4},{"id":"GO:0016188","count":4},{"id":"GO:0007269","count":4},{"id":"GO:0099525","count":4}]},{"hash":"2132924529957550083","title":"Collagen-Driven Skeletal Tissue Formation","description":"The top GO terms are dominated by collagen fibril organization, intramembranous ossification, and cartilage condensation, indicating a theme of extracellular matrix remodeling and skeletal development. Some additional terms relate to collagen signaling and cell adhesion, which fit into connective tissue formation, while a few outliers are less central to this cluster\u2019s main function.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0034381","count":2},{"id":"GO:0033034","count":2},{"id":"GO:2000860","count":2},{"id":"GO:0001957","count":2}]},{"hash":"1664604877666195370","title":"Ubiquitin-Mediated Proteolysis and Signaling","description":"This cluster is dominated by ubiquitination and degradation pathways (ubiquitin-dependent proteolysis, protein ubiquitination, autoubiquitination, ERAD-related terms, and K6-linked ubiquitination) coupled with signaling regulation (JNK cascade and I-kappaB phosphorylation) and intracellular signal transduction, with a note on immune regulation (neutrophil activation) and cell division. These together point to a cohesive module where ubiquitin tagging governs protein turnover and modulates signaling pathways.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0016567","count":4},{"id":"GO:0035556","count":3},{"id":"GO:0030433","count":3},{"id":"GO:1902564","count":2}]},{"hash":"750598279390079","title":"Immune signaling and inflammatory pathways","description":"The proteins are enriched for immune-related signaling: B cell receptor signaling, interleukin-10 production, and NF-kappaB/MAPK (ERK) pathway regulation, along with Rho signaling and endothelial chemotaxis via VEGF signaling. Proteolysis also appears, which can participate in inflammatory remodeling. Together, these terms point to a cohesive theme of immune communication and inflammatory regulation, with some vascular signaling connections, justifying a single label that captures this core function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0002318","count":2}]},{"hash":"386763377434045863","title":"Unknown","description":"The GO terms are highly diverse, spanning extracellular matrix processes (collagen fibril organization), immune regulation (adaptive immune response, negative regulation of IL-8 production, TH2 differentiation), cytoskeletal and exocytosis-related processes, neural/glial development (gliogenesis), and reproductive cycling (estrous cycle). With no edges or consistent functional theme tying the proteins together, there isn\u2019t a clear shared function to name this cluster.  ","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":2},{"id":"GO:0009414","count":1},{"id":"GO:0045629","count":1},{"id":"GO:0031532","count":1},{"id":"GO:0002250","count":1}]},{"hash":"1381639930794813417","title":"Neural Development and Signaling","description":"Top terms indicate nervous system development and signaling pathways (neuron development, myelin assembly, vocalization behavior, Wnt/JNK signaling, glucocorticoid signaling, GTPase regulation), with some pleiotropic terms like heart development and apoptosis. This suggests the proteins collectively participate in neural development and associated signaling rather than a single, isolated function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032288","count":2},{"id":"GO:0097178","count":2},{"id":"GO:0071625","count":2},{"id":"GO:0042921","count":2},{"id":"GO:0006915","count":2}]},{"hash":"921899412317975695","title":"Unknown","description":"The terms span core gene expression (DNA-templated transcription, translation) and genome maintenance (DNA replication, DNA repair) alongside diverse developmental and physiological processes (heart development, labyrinthine layer blood vessel development, potassium transport) and immune signaling (T cell receptor pathway). This mix lacks a single coherent functional theme, so a specific label is not warranted beyond Unknown.","confidence":"","size":15,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0009636","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0006260","count":3}]},{"hash":"2134976117677568943","title":"DNA Damage Response and Repair","description":"Proteins in this cluster are enriched for core DNA maintenance processes: base-excision repair, DNA replication, recombination and transposition, along with DNA-templated transcription and mitotic recombination resolution. The presence of apoptotic processes and responses to xenobiotic/toxic substances further supports a role in DNA damage sensing and repair, with downstream stress and cell-fate signaling. Together, these terms point to a cohesive DNA damage response and genome maintenance program under stress.","confidence":"High","size":15,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0042493","count":3},{"id":"GO:0006310","count":3},{"id":"GO:0006284","count":3},{"id":"GO:0006313","count":3}]},{"hash":"714878804415863423","title":"Rho/Rac GTPase Signaling and Cytoskeletal Dynamics","description":"The cluster is dominated by terms related to Rho/Rac family GTPase signaling and cytoskeletal remodeling (regulation of Rho/Rac signaling, small GTPase-mediated signaling, microspike assembly). While there are also development-related terms (nervous system and heart development) and signaling context (GPCR desensitization, B cell receptor signaling), the common thread appears to be GTPase-driven signaling that governs actin dynamics and cell structure.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0010765","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0050853","count":3}]},{"hash":"428780986094993978","title":"Glutamatergic synaptic signaling and plasticity","description":"The terms are centered on neuronal communication and plasticity\u2014glutamatergic synaptic transmission, excitatory postsynaptic potentials, regulation of long-term synaptic plasticity, sensory perception, and memory\u2014pointing to a glutamatergic, plastic synapse. Potassium transport suggests neuronal excitability. An outlier term about bone ossification appears incidental to the neuronal theme.","confidence":"High","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048169","count":5},{"id":"GO:0060079","count":5},{"id":"GO:0050975","count":5},{"id":"GO:0035249","count":4},{"id":"GO:0007399","count":4}]},{"hash":"272820378623675460","title":"Nuclear RNA processing and chromatin regulation","description":"These terms point to nuclear RNA processing (ribosome biogenesis, snRNP assembly) and chromatin regulation (heterochromatin formation, DNA transposition) with cell cycle links, suggesting a cluster of proteins involved in nuclear gene expression control.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0000387","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0070373","count":2},{"id":"GO:0090263","count":2}]},{"hash":"2261143100139744308","title":"Plant cell wall polysaccharide biosynthesis and pollen exine formation","description":"The top GO terms point to plant-specific processes in constructing and organizing the cell wall (glucuronoxylan biosynthesis, chondroitin/dermatan sulfate-related biosynthesis terms, and cell wall organization) and pollen wall development (pollen exine formation), with supporting signals from root hair development and infection structure formation. This suggests a coherent cluster of proteins involved in plant cell wall polysaccharide assembly and pollen wall-related processes, despite some cross-annotation noise.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009834","count":3},{"id":"GO:0010417","count":3},{"id":"GO:0015012","count":3},{"id":"GO:0050650","count":3},{"id":"GO:0050651","count":2}]},{"hash":"375317851604452375","title":"Cell signaling and transcriptional regulation","description":"These proteins show enrichment in both signaling pathways (T cell receptor signaling, Wnt signaling regulation, ER stress\u2013related apoptotic signaling) and core gene expression/processing processes (mRNA processing, transcription, nuclear export), plus a centrosome duplication term, suggesting a cohesive theme where signaling interfaces with transcriptional control and cell cycle regulation.","confidence":"Medium","size":15,"edges":48,"triangles":80,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009190","count":6},{"id":"GO:0046827","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0090263","count":4},{"id":"GO:0051436","count":4}]},{"hash":"1891575127088185886","title":"Unknown","description":"The top GO terms are highly heterogeneous, including insect cuticle development, proton transport, mitochondrial complex IV assembly, and several steroid and lipid metabolic processes. Because there is no single dominant biological function or pathway that ties all 15 proteins together, a specific, representative label cannot be assigned with confidence.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:1902600","count":1},{"id":"GO:0042774","count":1},{"id":"GO:0033617","count":1},{"id":"GO:0008209","count":1}]},{"hash":"1054065870357672982","title":"Membrane transport of lipids and xenobiotics","description":"Top GO terms cluster around transmembrane transport of xenobiotics, vitamins, cholesterol and phospholipids, and amino acids, with cholesterol homeostasis and efflux also represented. This suggests a group of membrane transport proteins facilitating uptake/export of diverse lipids and small molecules; an outlier term on RNA nuclease regulation appears incidental.","confidence":"High","size":15,"edges":15,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":8},{"id":"GO:0035461","count":8},{"id":"GO:0042891","count":7},{"id":"GO:0030299","count":5},{"id":"GO:0042632","count":5}]},{"hash":"12030544393508843","title":"Neural-Muscle-Immune Developmental Signaling","description":"This cluster includes neural development (axon guidance), muscle development (myoblast fusion and differentiation), and various immune-related processes (B cell signaling, dendritic cell differentiation, MCP-1 production, NK cell regulation). The shared thread appears to be broad developmental signaling across neural, muscular, and immune lineages rather than a single pathway, justifying the composite label.","confidence":"Medium","size":15,"edges":9,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008045","count":3},{"id":"GO:0007520","count":3},{"id":"GO:2001200","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0060079","count":3}]},{"hash":"998939864995607463","title":"Embryonic Morphogenesis and Transcription Regulation","description":"The top GO terms point to broad roles in embryonic development across multiple organs (pancreas, digestive tract, eye, heart outflow tract, neural crest) combined with transcriptional control (negative regulation of RNAP II, DNA-templated transcription). This suggests a cluster of proteins coordinating organogenesis and transcriptional regulation rather than a single tissue-specific pathway.","confidence":"Medium","size":15,"edges":40,"triangles":38,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0031018","count":5},{"id":"GO:0090190","count":4},{"id":"GO:0048557","count":4},{"id":"GO:0006351","count":4}]},{"hash":"1953504335881593971","title":"Glycan and glycosphingolipid biosynthesis","description":"The GO terms are dominated by carbohydrate- and glycosphingolipid-biosynthesis processes, including trehalose, starch, glycogen, maltose, alpha-glucan, globoside, and mannosyl-inositol phosphorylceramide pathways, indicating a cohesive theme of glycan/glycolipid assembly across the proteins.","confidence":"High","size":15,"edges":16,"triangles":1,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0051999","count":4},{"id":"GO:0036210","count":4},{"id":"GO:0001576","count":4},{"id":"GO:0000023","count":4},{"id":"GO:0019252","count":3}]},{"hash":"1912348054397122313","title":"Innate Immune Response and ECM Remodeling","description":"The cluster is enriched in terms related to innate defense (defense against Gram-positive bacteria, neutrophil-mediated killing of fungus, response to yeast) and leukocyte recruitment (positive regulation of leukocyte tethering or rolling), along with extracellular matrix remodeling signals (elastin catabolic process, digestion) and coagulation-related activation (Factor XII). The presence of Wnt signaling and growth/regulation terms suggests concurrent roles in development/proliferation, but the dominant theme centers on immune activation with tissue remodeling. ","confidence":"High","size":15,"edges":25,"triangles":14,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":8},{"id":"GO:0050830","count":8},{"id":"GO:0042127","count":7},{"id":"GO:1903238","count":7},{"id":"GO:0060309","count":7}]},{"hash":"202461165992295136","title":"Larval chitin-based cuticle development","description":"The cluster is dominated by GO:0008363 (larval chitin-based cuticle development), with 8 proteins annotated to this term, suggesting a cohesive role in larval exoskeleton formation; the sparse connectivity (one edge, no triangles) supports a focused, developmentally linked protein set.","confidence":"High","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":8}]},{"hash":"2155160824696530968","title":"Unknown","description":"These 15 proteins span diverse biological themes: chitin catabolic process, inflammatory mediator production, carbohydrate metabolism, chemokine production regulation, DNA damage response and chromatin maintenance, apoptosis signaling, replication stress, aging, and antibody isotype switching. There is no single coherent function tying these GO terms together, suggesting the cluster is not functionally cohesive.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":1},{"id":"GO:0002532","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0090197","count":1},{"id":"GO:0045910","count":1}]},{"hash":"2076181651178267054","title":"Glutamatergic Synaptic Transmission and Plasticity","description":"Most terms center on neural signaling and memory, including glutamatergic synaptic transmission, long-term synaptic plasticity, memory-related processes (medium-term memory, conditioned taste aversion), and ion transport/receptor internalization, pointing to a cluster of proteins involved in neural communication and memory formation. Some development-related terms appear incidental rather than core to function.","confidence":"High","size":15,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0072375","count":10},{"id":"GO:0010226","count":10},{"id":"GO:0071805","count":10},{"id":"GO:0001661","count":10},{"id":"GO:0050806","count":10}]},{"hash":"982958886504719608","title":"Arabinogalactan Protein\u2013Mediated Root Hair and Seed Coat Mucilage Biosynthesis","description":"The top GO terms cluster around arabinogalactan protein metabolic processes, root hair cell development, and seed coat mucilage biosynthesis, as well as related glycosylation pathways. This suggests a cohesive plant cell-wall glycoprotein biosynthesis theme centered on AGPs that promote root hair growth and mucilage production in seeds, despite a few animal- or non-specific terms in the set. ","confidence":"High","size":15,"edges":50,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":3},{"id":"GO:0080147","count":3},{"id":"GO:0010405","count":3},{"id":"GO:0001744","count":3},{"id":"GO:0010493","count":3}]},{"hash":"53795043714199279","title":"RNA processing and translation regulation in development","description":"The cluster is dominated by RNA processing and translation-related GO terms: splicing via spliceosome, translation reinitiation, formation of the translation preinitiation complex, and (obsolete) polyadenylation. Coupled with terms for multicellular growth and lens fiber differentiation, this suggests a shared theme of RNA processing and protein synthesis control implicated in developmental processes. A few terms like defense response are present but appear peripheral. Confidence: Medium.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0000398","count":5},{"id":"GO:0035264","count":4},{"id":"GO:0070306","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0002188","count":4}]},{"hash":"119865477372395057","title":"Nematode development, reproduction, and molting","description":"This cluster centers on developmental and reproductive processes, with emphasis on nematode biology: maternal axis specification, Wnt signaling, embryonic morphogenesis; proteolysis and cuticle/molting processes; and reproductive interactions such as polyspermy prevention and regulation of sperm binding, plus nematode-specific pharyngeal pumping. The combination suggests proteins involved in nematode development, morphogenesis, molting, and reproduction.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060468","count":2},{"id":"GO:0048632","count":2},{"id":"GO:0007313","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0018996","count":2}]},{"hash":"1652396167190662742","title":"Neuronal SNARE-mediated vesicle trafficking and exocytosis","description":"This cluster centers on Golgi-to-transport vesicle pathways and SNARE-driven fusion, combined with neuronal exocytosis and receptor trafficking at the synapse. The prominent terms\u2014intra-Golgi and ER-to-Golgi transport, Golgi ribbon formation, SNARE complex assembly, vesicle fusion with Golgi, exocytic insertion of neurotransmitter receptors, and neurotransmitter secretion/LTP\u2014point to a cohesive role in delivering vesicles to the synaptic membrane and mediating neurotransmitter release and receptor targeting.","confidence":"High","size":15,"edges":55,"triangles":55,"max_degree":11,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006891","count":9},{"id":"GO:0006888","count":9},{"id":"GO:0090161","count":9},{"id":"GO:0048280","count":9},{"id":"GO:0098967","count":8}]},{"hash":"891548687815878187","title":"DNA replication, repair, and genome integration cluster","description":"The proteins here are strongly associated with DNA metabolism, including DNA recombination, base-excision repair, DNA replication, RNA-templated DNA biosynthesis, and DNA integration (plus proviral latency). While there are ancillary terms related to xenobiotic response and RNAi regulation, the dominant signal centers on genome maintenance and integration processes, justifying this label as representative of the cluster's function.","confidence":"High","size":15,"edges":33,"triangles":8,"max_degree":11,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":8},{"id":"GO:0006284","count":7},{"id":"GO:0007568","count":7},{"id":"GO:0042493","count":7},{"id":"GO:0006278","count":6}]},{"hash":"1840545450296125768","title":"Neural development and migration signaling","description":"The top GO terms cluster around brain development, neuronal stem cell maintenance, and cell/epithelium migration, with associated signaling pathways like Wnt, AKT activation, and stress-activated MAPK, plus microtubule anchoring at the centrosome relevant to neural progenitor division. Although a term about invasive growth in response to glucose limitation appears, the dominant theme is neural development and migration signaling. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001403","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0007252","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0090132","count":2}]},{"hash":"2216636546239402310","title":"T Cell Signaling and Apoptosis","description":"The top GO terms are dominated by immune-related processes\u2014T cell receptor signaling, positive regulation of T cell differentiation, and related signaling\u2014with additional terms for apoptosis and GPCR signaling regulation. These collectively point to T cell activation and controlled survival signaling as the core theme of the cluster, despite some unrelated terms referencing vascular or neuronal processes. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060716","count":6},{"id":"GO:0046638","count":6},{"id":"GO:0031532","count":5},{"id":"GO:0007409","count":5},{"id":"GO:0010898","count":5}]},{"hash":"872943335078279807","title":"Ubiquitin-Dependent Proteolysis","description":"This cluster is dominated by GO terms for ubiquitin-mediated protein degradation, including ubiquitin-dependent proteolysis, protein polyubiquitination, and ERAD pathways, indicating a proteostasis-centric group. Additional terms relate to signaling modulation (TNF, I-kappaB, JNK) and circadian regulation, suggesting broader regulatory links but the core theme remains ubiquitin-proteasome/ERAD\u2013driven degradation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0007519","count":3},{"id":"GO:0051865","count":3},{"id":"GO:1903265","count":3},{"id":"GO:0030433","count":3}]},{"hash":"904261663362974297","title":"Ubiquitin-dependent protein turnover and NF-kappaB signaling","description":"This cluster is dominated by GO terms for ubiquitin-mediated protein degradation (including ubiquitin-dependent proteolysis, K48- and K63-linked ubiquitination, autoubiquitination, and polyubiquitination) and regulatory roles in apoptosis, necroptosis, histone turnover, and activation of canonical NF-kappaB signaling. The common theme is ubiquitin-mediated regulation of protein stability and downstream signaling affecting cell survival and transcription, making this label appropriate and specific.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0051865","count":4},{"id":"GO:0070936","count":4},{"id":"GO:0046621","count":4},{"id":"GO:0043066","count":4}]},{"hash":"63010347252417155","title":"Angiogenesis and Renin-Angiotensin Regulation","description":"These proteins show GO terms centered on vascular development and blood pressure control (angiogenesis, angiotensin maturation, renin-angiotensin\u2013regulated blood pressure), with supporting signals for immune signaling and glycosylation (adaptive immune response, Lewis a biosynthesis, protein glycosylation). The core theme is angiogenesis and cardiovascular regulation, with immune and glycan context.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0010493","count":3},{"id":"GO:0002250","count":2},{"id":"GO:0045766","count":2}]},{"hash":"2190642404670936781","title":"Insect larval chitin-based cuticle development","description":"This cluster is dominated by the GO term GO:0008363, describing larval chitin-based cuticle development, with 14 proteins annotated to it. The high connectivity (82 edges, 274 triangles) suggests a cohesive module of proteins involved in the synthesis/assembly of the larval exoskeleton in insects, i.e., chitin-based cuticle formation. Confidence is high that the label captures the shared function of the cluster.","confidence":"High","size":14,"edges":82,"triangles":274,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":14}]},{"hash":"1022576736186808403","title":"Developmental Transcription Regulation and Chromatin Remodeling","description":"This cluster centers on transcriptional control by RNA polymerase II, including negative regulation, and is connected to chromatin remodeling, suggesting a core role for transcription factors and epigenetic regulators. The presence of tissue-development terms (ventricular myocardium morphogenesis, skeletal muscle differentiation, endocrine pancreas development, hepatocyte proliferation) indicates these regulators act broadly to drive developmental processes across multiple organs. The IL-4\u2013related term hints at signaling-responsive transcriptional regulation as well. Overall, the proteins likely function as chromatin-modifying transcription regulators coordinating developmental programs.","confidence":"High","size":14,"edges":67,"triangles":172,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071353","count":7},{"id":"GO:0000122","count":6},{"id":"GO:0006366","count":6},{"id":"GO:0043044","count":5},{"id":"GO:0036091","count":5}]},{"hash":"2086713717046333142","title":"Stress- and inflammation-regulated vesicle exocytosis","description":"These proteins cluster around stress and inflammatory signaling (reacting to hydrogen peroxide, IL-1, TNF) and processes governing vesicle trafficking and secretion (synaptic vesicle exocytosis, synapse assembly), with links to insulin secretion regulation and lipid metabolism. The shared theme appears to be modulation of secretory pathways in response to stress and immune signals, justifying a medium confidence in this label.","confidence":"Medium","size":14,"edges":45,"triangles":38,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":3},{"id":"GO:0032024","count":3},{"id":"GO:0010796","count":3},{"id":"GO:2000300","count":3},{"id":"GO:0031384","count":3}]},{"hash":"1410262178958452902","title":"Synaptic plasticity and apoptosis regulation","description":"The cluster is enriched for neuronal signaling terms, with strong representation of long-term potentiation, glutamatergic synaptic transmission, and visual perception, along with both positive and negative regulation of apoptotic processes. These suggest a core theme around synaptic function and cell death control. The presence of mitotic cell cycle and kinetochore localization terms, while present, appear peripheral or reflective of proteins with dual roles, making the overall signal more about neuronal signaling and apoptosis than strictly cell-cycle processes.","confidence":"Medium","size":14,"edges":67,"triangles":210,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033160","count":11},{"id":"GO:0000278","count":11},{"id":"GO:0034501","count":11},{"id":"GO:0045736","count":11},{"id":"GO:0007601","count":11}]},{"hash":"1893705982374067485","title":"Neural development and axon guidance signaling","description":"The top GO terms cluster around nervous system development, axon guidance, ROBO (Roundabout) signaling, and SHH/Smoothened signaling, plus ERK and Rho-mediated pathways that influence growth cone navigation and cytoskeletal remodeling. While some terms like myoblast fusion or synaptic vesicle exocytosis are broader signaling processes, the prevailing themes point to neural morphogenesis and neuron pathfinding.","confidence":"Medium","size":14,"edges":56,"triangles":85,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043552","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0007520","count":5}]},{"hash":"1273058380692044523","title":"Unknown","description":"The top GO terms span immune response, hair follicle maturation, axonogenesis, RNA splicing machinery, DNA replication initiation, and lipid catabolism, with no clear shared pathway or function linking them. The absence of edges further suggests there isn\u2019t a cohesive module, so a single functional label isn\u2019t supported.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033160","count":2},{"id":"GO:0007118","count":2},{"id":"GO:0032298","count":2},{"id":"GO:0048820","count":2},{"id":"GO:0000387","count":1}]},{"hash":"1738432376071547695","title":"Cerebellar development and ER calcium homeostasis","description":"The top GO terms include cerebellar Purkinje cell differentiation and cerebellar granular layer development, pointing to cerebellar neuron development, while terms like endoplasmic reticulum calcium ion homeostasis and regulation of calcium transport suggest a link to ER calcium regulation. Together, they indicate a cluster centered on cerebellar development with ER calcium/homeostasis connections.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090005","count":2},{"id":"GO:0021702","count":1},{"id":"GO:1902045","count":1},{"id":"GO:0010523","count":1},{"id":"GO:0032469","count":1}]},{"hash":"1346912733339887226","title":"Nuclear RNA Splicing and Decay","description":"The top GO terms strongly point to nuclear RNA processing activities: multiple entries for spliceosome-mediated splicing (including prespliceosome assembly and general splicing), regulatory ncRNA-mediated gene silencing, and RNA quality control via nonsense-mediated decay, along with rRNA processing and transcription termination. This suggests a cohesive cluster centered on splicing and RNA surveillance in the nucleus, with some ancillary chromatin-related terms likely reflecting broader nuclear regulation.","confidence":"High","size":14,"edges":58,"triangles":113,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":11},{"id":"GO:0048026","count":11},{"id":"GO:0000398","count":8},{"id":"GO:0000464","count":8},{"id":"GO:0006306","count":7}]},{"hash":"2019052126460034744","title":"Developmental Growth and Cell Cycle Regulation","description":"The cluster\u2019s top GO terms center on organismal growth and development (multicellular organism growth, forebrain development) and cell cycle control (regulation of cell cycle checkpoint, cell division), indicating a core function in growth and proliferation. Supporting terms cover signaling modulation, nuclear transport, ribosome biogenesis, and cytoskeletal dynamics, suggesting a broad developmental/proliferative program rather than a single pathway.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0061099","count":5},{"id":"GO:1901976","count":5},{"id":"GO:0035264","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0031081","count":5}]},{"hash":"47464874664946498","title":"Innate Immune Defense and Leukocyte Recruitment","description":"The top GO terms show clear enrichment for innate immune responses: defense against Gram-positive bacteria, complement activation via the lectin pathway, and neutrophil-mediated killing, plus positive regulation of leukocyte tethering or rolling, indicating inflammation and recruitment of immune cells. While there are some non-immune terms (developmental and transcriptional regulation) that are less central to the cluster, the dominant pattern centers on innate immunity and inflammatory processes, with some accompanying extracellular matrix remodeling and coagulation-related activity. This supports labeling the cluster as innate immune defense with leukocyte recruitment. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0035264","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0001867","count":5},{"id":"GO:0007338","count":5},{"id":"GO:0000122","count":4}]},{"hash":"408097776882923300","title":"Proteoglycan GAG biosynthesis and sulfation","description":"This cluster is dominated by glycosaminoglycan (GAG) biosynthetic terms (chondroitin sulfate, heparan/heparin, keratan sulfate proteoglycans) and sulfation-related processes, suggesting a cohesive theme around proteoglycan synthesis and sulfation pathways. The inclusion of sulfate assimilation and protein sulfation supports a broader sulfation/metabolic context, though a few terms (xenobiotic metabolism, bile acid catabolism, angiotensin regulation) are less directly tied, their link to sulfation/biosynthetic regulation offers a plausible connection. Overall, the label captures the core functional theme of GAG biosynthesis and sulfation. ","confidence":"Medium","size":14,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030206","count":6},{"id":"GO:0015015","count":6},{"id":"GO:0006805","count":5},{"id":"GO:0000103","count":5},{"id":"GO:0002002","count":5}]},{"hash":"1595065015001311559","title":"Mitochondrial transport and membrane dynamics","description":"This cluster is dominated by GO terms tied to mitochondria, including membrane transport (phosphate and magnesium ions), membrane fission, regulation of membrane permeability, mtDNA maintenance, and nucleotide transport, as well as thiamine pyrophosphate transport. Together these terms point to a cohesive role in mitochondrial membrane function and transport processes, with additional terms related to broader cellular stress responses that may accompany mitochondrial activity.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0034198","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0008637","count":4},{"id":"GO:0030974","count":4},{"id":"GO:0000002","count":4}]},{"hash":"267022507771796036","title":"DNA Repair and Oxidative Stress Response","description":"The top GO terms show DNA repair activities (base-excision repair, DNA recombination) together with cellular responses to oxidative stress (hydrogen peroxide, redox homeostasis) and apoptotic signaling. While there are other terms present (e.g., dephosphorylation, fucose catabolism), the strongest link is maintenance of genome integrity under oxidative stress and associated stress signaling, which justifies a cohesive label around DNA repair and oxidative stress response.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042355","count":3},{"id":"GO:0016311","count":2},{"id":"GO:0071375","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0006284","count":2}]},{"hash":"1805882758078584981","title":"Protein acetylation and chromatin regulation","description":"This cluster is enriched for multiple acetylation-related GO terms (putrescine, spermine, peptidyl-lysine, N-terminal, histone H4, and propionylation) and for chromatin-associated processes (subtelomeric heterochromatin formation), with additional links to melatonin biosynthesis and leaf formation regulation in plants, suggesting a core function in acetylation-driven protein modification and chromatin state control.","confidence":"High","size":14,"edges":34,"triangles":20,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0030187","count":7},{"id":"GO:0032920","count":7},{"id":"GO:0018003","count":7},{"id":"GO:0032919","count":7},{"id":"GO:0017198","count":7}]},{"hash":"1828186819305623499","title":"Telomere maintenance and spindle assembly","description":"The top GO terms cluster around telomere maintenance via telomerase, telomere capping, and telomeric cohesion, alongside spindle assembly, suggesting a functional module coordinating telomere protection with mitotic chromosome segregation. Some broader terms appear but the strongest signals are telomere- and chromosome-structure\u2013related processes, indicating a theme of genome stability during cell division.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":4},{"id":"GO:0051225","count":4},{"id":"GO:0016055","count":3},{"id":"GO:0006397","count":3},{"id":"GO:1904908","count":3}]},{"hash":"499939443738707758","title":"Innate Immune Response and Skin Development","description":"The top GO terms cluster around innate immunity (innate immune response, complement activation, MCP-1 production) and tissue-related processes such as skin development and protein oligomerization, suggesting proteins involved in immune defense with broader tissue-context roles. A few terms (mechanosensory detection of sound, ubiquitin-mediated ERAD, cell division) are less coherent with the main theme, so the overall label reflects a primary emphasis on immune function with developmental/tissue context.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0050910","count":2},{"id":"GO:0071639","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0051965","count":2}]},{"hash":"217759587007685867","title":"Unknown","description":"The proteins span a diverse mix of functions (developmental processes like salivary gland morphogenesis and hair follicle development, various metabolic processes, neuronal apoptosis, and transcription regulation) with no clear single theme or pathway uniting them, and several terms are obsolete. This prevents a concise, confident label beyond Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0006012","count":2},{"id":"GO:0007435","count":2},{"id":"GO:0051402","count":2},{"id":"GO:0001942","count":2}]},{"hash":"1466906125654516653","title":"Ubiquitin-Dependent Degradation and Signaling","description":"Top GO terms are dominated by ubiquitin-related processes: ubiquitin-dependent protein catabolic process, autoubiquitination, various ubiquitin linkages, and histone ubiquitination. Additional terms point to regulation of signaling pathways (JNK cascade, I-kappaB phosphorylation). This suggests a cluster centered on ubiquitination machinery governing protein turnover and signaling rather than a single substrate.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0051865","count":3},{"id":"GO:1903762","count":3},{"id":"GO:1901253","count":3},{"id":"GO:0051301","count":3}]},{"hash":"178562818932260187","title":"Glycolysis, TCA cycle, and porphyrin biosynthesis","description":"This cluster is dominated by core energy metabolism terms (glycolysis, tricarboxylic acid cycle, 2-oxoglutarate metabolism) and related biosynthetic processes such as protoporphyrinogen IX/porphyrin biosynthesis, with only a minor Notch signaling term. The overall theme points to central carbon metabolism and heme/porphyrin precursor production rather than a single signaling pathway.","confidence":"Medium","size":13,"edges":59,"triangles":131,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":4},{"id":"GO:0006096","count":4},{"id":"GO:0033512","count":3},{"id":"GO:0006103","count":3},{"id":"GO:0009102","count":2}]},{"hash":"203845533414800159","title":"Redox metabolism and detoxification under stress","description":"The cluster features oxidation-reduction and detoxification processes (redox, NADH oxidation, formaldehyde and amino acid-derived alcohol metabolism), plus stress-response terms (response to lipopolysaccharide, copper ion). Metabolic connections to fatty acid omega-oxidation and D-xylulose-5-phosphate biosynthesis link to energy and redox balance. This suggests a cohesive redox-detoxification theme under stress.","confidence":"Medium","size":13,"edges":41,"triangles":68,"max_degree":10,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0032496","count":7},{"id":"GO:0010430","count":6},{"id":"GO:0000947","count":6},{"id":"GO:0046294","count":6}]},{"hash":"1585663967117757377","title":"Kidney development and nephron morphogenesis","description":"Several GO terms point to developmental processes specific to the kidney (kidney development, mesonephric duct development, metanephric distal tubule morphogenesis), suggesting the cluster is best described by a kidney development/morphogenesis theme. Other terms like basophil/platelet activation or fungal response appear ancillary or pleiotropic, but do not override the dominant developmental signature.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":3},{"id":"GO:0001502","count":3},{"id":"GO:0060355","count":3},{"id":"GO:0006910","count":3},{"id":"GO:0072177","count":3}]},{"hash":"1639680333602052105","title":"Ion and sugar transmembrane transport","description":"The top GO terms point to a set of membrane transporters handling a range of substrates: nitrate, nitrite, phosphate, sodium, potassium, galactose, arabinose, and sialic acid, with an additional term for neurotransmitter loading into synaptic vesicles. This pattern suggests a cluster of proteins whose common function is transmembrane transport of ions and small molecules, with a possible subset specialized for vesicular neurotransmitter handling in neurons.","confidence":"Medium","size":13,"edges":23,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0035435","count":3},{"id":"GO:0098700","count":3}]},{"hash":"849236887328810812","title":"Developmental transcription regulators","description":"The TOP terms cluster around transcriptional control (DNA-templated transcription, RNA polymerase II) and tissue-specific differentiation (skeletal muscle, pancreas, lens, spinal cord neurons), with signaling responses (IL-4, TGF-beta) indicating integration of signaling pathways into developmental transcriptional regulation.","confidence":"High","size":13,"edges":14,"triangles":3,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0035914","count":5},{"id":"GO:0031018","count":5},{"id":"GO:0071353","count":4},{"id":"GO:2001111","count":4}]},{"hash":"605201946589736974","title":"Glycosaminoglycan/Proteoglycan Biosynthesis","description":"The top GO terms are dominated by proteoglycan biosynthetic processes (heparin, keratan sulfate, and related proteoglycans) and related sulfation pathways, suggesting a core function in the production/modification of sulfated glycosaminoglycans that form the extracellular matrix. Other metabolic terms (xenobiotic, bile acid, flavonoid metabolism) appear less cohesive with this theme, making proteoglycan biosynthesis the strongest, most representative signal.","confidence":"Medium","size":13,"edges":11,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051881","count":4},{"id":"GO:0006805","count":4},{"id":"GO:0000103","count":4},{"id":"GO:0030206","count":4},{"id":"GO:0002002","count":4}]},{"hash":"1950494944438030017","title":"Diverse membrane nutrient and ion transporters","description":"Top GO terms indicate transmembrane transport of diverse substrates (nitrite, nitrate, sialic acid, arabinose, vitamins, potassium ions) and a vesicle-related transport process, suggesting a cluster of transporter proteins with broad substrate specificity. The presence of an unrelated term like cell division may reflect annotation noise, but the overall theme is membrane transport across nutrients and ions. ","confidence":"High","size":13,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0006004","count":2},{"id":"GO:0042891","count":2},{"id":"GO:0098700","count":2},{"id":"GO:0015707","count":2}]},{"hash":"47607359926005521","title":"Immune Signaling and Cardiac Calcium Regulation","description":"Based on the top GO terms, the cluster features strong representation of immune signaling (T cell receptor signaling, monocyte differentiation, TGF-beta\u2013related responses) alongside calcium handling and regulation of cardiac muscle contraction (calcium release from the sarcoplasmic reticulum, regulation of cardiac contraction). The mix suggests a broad signaling module rather than a single, narrow function, potentially reflecting immune\u2013cardiac signaling cross-talk or shared regulatory pathways. ","confidence":"Medium","size":13,"edges":26,"triangles":8,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":7},{"id":"GO:0030224","count":6},{"id":"GO:0055118","count":6},{"id":"GO:0071560","count":6},{"id":"GO:0010753","count":6}]},{"hash":"791136720409119477","title":"Regulation of signaling and lipid metabolism","description":"The top GO terms point to various regulatory roles in signaling pathways (ERK cascade, Wnt, dendritic spine morphogenesis) alongside lipid metabolic processes (fatty acid oxidation, cholesterol efflux) and related regulatory activities. This suggests a cluster of proteins broadly involved in modulating signaling dynamics and lipid homeostasis rather than a single, cohesive pathway. Other terms touch on immune and adhesion processes, which can interface with signaling and metabolism, but the overarching theme remains regulatory control of signaling and lipid metabolism.","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":"wound healing","top_go_terms":[{"id":"GO:0061003","count":8},{"id":"GO:0034115","count":6},{"id":"GO:0033034","count":6},{"id":"GO:2000860","count":6},{"id":"GO:0070373","count":6}]},{"hash":"1803339597072399947","title":"Wnt-regulated transcription and tissue differentiation","description":"GO terms center on transcriptional regulation (DNA-templated transcription, negative regulation of transcription by RNA Pol II) and multiple differentiation processes (Leydig cell differentiation, mammary gland alveolus development, multi-ciliated epithelial cell differentiation) with canonical Wnt signaling. This suggests a cohesive role in coordinating transcriptional programs during tissue differentiation via Wnt signaling, despite a few less-specific terms. ","confidence":"Medium","size":13,"edges":19,"triangles":11,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0032026","count":6},{"id":"GO:0033327","count":5},{"id":"GO:0060749","count":5},{"id":"GO:0000122","count":5}]},{"hash":"52991240850371678","title":"Diverse Substrate Membrane Transporters","description":"This cluster is dominated by transmembrane transport GO terms across a variety of substrates (nitrite/nitrate, sugars, sialic acid, vitamins, xenobiotics) and even neurotransmitter loading into synaptic vesicles, indicating a group of membrane transporter proteins with broad substrate specificity.","confidence":"High","size":13,"edges":10,"triangles":1,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006004","count":2},{"id":"GO:0042891","count":2},{"id":"GO:0098700","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0071805","count":2}]},{"hash":"398462293920211847","title":"RNA metabolism and ribosome biogenesis","description":"The cluster\u2019s top GO terms center on RNA processing and turnover (nonsense-mediated decay, prespliceosome assembly, RNA polyadenylation-dependent rRNA catabolism, transcription termination) and on ribosome biogenesis (cytosolic and mitochondrial large subunit assembly), indicating a cohesive theme around RNA metabolism and ribosome production.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006306","count":13},{"id":"GO:0070870","count":13},{"id":"GO:0000184","count":13},{"id":"GO:1903241","count":13},{"id":"GO:0071035","count":13}]},{"hash":"4852455728150300","title":"DNA Transcription and RNA Processing Machinery","description":"The top terms center on RNA polymerase II promoter clearance, transcription open complex formation, and nonsense-mediated decay, pointing to transcription initiation and RNA processing. While there are DNA metabolism and repair terms (unwinding, recombination, methylation), the dominant theme is nuclear transcription and RNA processing, with some ancillary DNA maintenance roles.","confidence":"Medium","size":13,"edges":71,"triangles":217,"max_degree":12,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0032508","count":4},{"id":"GO:0006310","count":3},{"id":"GO:0044806","count":3},{"id":"GO:0006306","count":2},{"id":"GO:0033683","count":2}]},{"hash":"2168473670525751514","title":"Cell Cycle, Transcription, and RNA Export","description":"Based on the frequent GO terms, the proteins cluster around core cell cycle activities (mitotic cell cycle, DNA replication, cell division) and transcription/RNA processing (transcription initiation, mRNA export). Additional terms point to vesicle formation and apoptosis, with a minor signal of innate immune response, suggesting roles in stress-related regulation of gene expression and trafficking. Together, they reflect a cohesive theme of cell-cycle progression coupled to RNA handling.","confidence":"Medium","size":13,"edges":70,"triangles":212,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0000902","count":2},{"id":"GO:0070676","count":2},{"id":"GO:0006367","count":2}]},{"hash":"1768391180414510373","title":"Neural development and axon guidance signaling","description":"The top GO terms cluster around nervous system development (hippocampus development, nervous system development), neuron survival (negative regulation of neuron apoptotic process), and axon guidance, reinforcing a neural development and signaling theme (including ERK cascade regulation). Some terms like ossification and spermatid development may reflect broader developmental roles or annotation noise, but the dominant signal is neural development and axon guidance.","confidence":"High","size":13,"edges":37,"triangles":42,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021766","count":10},{"id":"GO:0043525","count":10},{"id":"GO:0007411","count":10},{"id":"GO:0032258","count":10},{"id":"GO:1902236","count":10}]},{"hash":"151063568402209580","title":"Excitatory synapse assembly and vesicle dynamics","description":"Most top GO terms cluster around neural synapse formation and function: assembly of presynaptic and postsynaptic membranes, excitatory synapse assembly, and regulation of excitatory postsynaptic potential, as well as positive regulation of synaptic vesicle clustering and endocytosis. A few terms (retina development, osteoblast development, glucocorticoid response) may reflect broader developmental or stress-response roles, but the dominant signal is synaptic assembly and vesicle trafficking in excitatory synapses.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":10},{"id":"GO:0002076","count":10},{"id":"GO:0002087","count":10},{"id":"GO:0097104","count":8},{"id":"GO:0097105","count":8}]},{"hash":"1395159185739764600","title":"Neuronal synaptic signaling and intracellular trafficking","description":"The cluster combines GO terms tied to synaptic function (regulation of long-term neuronal synaptic plasticity, excitatory postsynaptic potential, dendrite development) with intracellular transport between organelles (ER-to-Golgi and endosome-to-Golgi transport, Golgi localization) and cytoskeletal remodeling (stress fiber assembly). This pattern suggests a module where synaptic signaling is closely linked to vesicular trafficking and structural dynamics in neurons. Peripheral signals like touch perception and sprouting angiogenesis-related migration likely reflect broader neuronal development contexts but do not override the core theme. ","confidence":"High","size":13,"edges":22,"triangles":0,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048169","count":4},{"id":"GO:0033138","count":4},{"id":"GO:0051683","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0016358","count":4}]},{"hash":"761584432900125996","title":"Fucosylation and leukocyte migration","description":"This cluster is dominated by glycosylation-related terms (protein glycosylation, N-glycan fucosylation, Lewis a epitope biosynthesis, L-fucose catabolic process) and immune-related processes (CD4+CD25+ regulatory T cell differentiation, leukocyte migration), suggesting a shared function in fucose-containing glycan synthesis/modification that modulates immune cell trafficking. Some neuronal development terms appear as bystanders or reflect broader glycan roles, but the core signal centers on glycosylation and leukocyte movement.","confidence":"Medium","size":13,"edges":24,"triangles":6,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":6},{"id":"GO:0002361","count":5},{"id":"GO:0010493","count":5},{"id":"GO:0002522","count":5},{"id":"GO:0036071","count":5}]},{"hash":"622531587138243380","title":"GPCR Signaling in Retina and Dopaminergic Pathways","description":"This cluster is dominated by GO terms for GPCR signaling, adenylate cyclase activation, PLC pathways, dopamine regulation, adrenergic signaling, and photoreceptor maintenance, suggesting a coherent theme of GPCR-mediated sensory and dopaminergic signaling in the retina. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035025","count":7},{"id":"GO:0045777","count":7},{"id":"GO:0022900","count":7},{"id":"GO:0010579","count":7},{"id":"GO:0007190","count":6}]},{"hash":"1686432746455307727","title":"Inflammation and vascular remodeling","description":"The proteins show enrichment in innate immune activities (neutrophil-mediated killing, leukocyte tethering), endothelial barrier regulation, and extracellular matrix remodeling (elastin catabolism, Factor XII activation), plus growth and signaling roles (Wnt pathway, multicellular growth). Taken together, this points to a coordinated inflammatory response coupled with vascular/tissue remodeling, rather than a single, narrow function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042127","count":3},{"id":"GO:1903238","count":3},{"id":"GO:0060309","count":3},{"id":"GO:0002542","count":3},{"id":"GO:0070947","count":3}]},{"hash":"492496628297934988","title":"Vesicle Trafficking and Exocytosis","description":"The top GO terms cluster around secretory and trafficking processes: exocytosis, exocyst localization, Golgi-to-lysosome transport, protein retention in the Golgi, and endosome-related transport. This points to a cohesive function in vesicle formation, sorting, and exocytic trafficking through the Golgi\u2013endosome\u2013lysosome axis, with additional related roles in exosome assembly and NK cell degranulation. Although mitotic/centrosome terms appear, the dominant signal is secretory vesicle trafficking. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006887","count":3},{"id":"GO:0051601","count":2},{"id":"GO:0051661","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0035646","count":1}]},{"hash":"990905436582234925","title":"Inositol phosphate signaling and immune regulation","description":"The top GO terms are dominated by inositol phosphate metabolism and phosphatidylinositol phosphate biosynthesis (IP3/IP signaling), suggesting a lipid signaling module. Immune-related terms (neutrophil and myeloid cell regulation, thymic T cell selection) hint at IP signaling roles in immune processes. A couple of terms (pollen tube guidance, dendritic spine maintenance) seem tangential or noisy, but overall the pattern points to IP signaling in immune context rather than a single other specialized function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006525","count":1},{"id":"GO:0033030","count":1},{"id":"GO:0002262","count":1},{"id":"GO:0032957","count":1},{"id":"GO:0032958","count":1}]},{"hash":"1034476830752465931","title":"Coagulation and innate immune response","description":"The top GO terms cluster around blood coagulation (GO:0007596), complement activation (GO:0006958), and Factor XII activation (GO:0002542), with neutrophil-mediated killing (GO:0070947) and leukocyte tethering (GO:1903238)\u2014all indicative of coagulation intersecting innate immunity and inflammatory recruitment. Digestion and elastin catabolic processes suggest some tissue remodeling, and Wnt signaling and multicellular growth are more general hints. Overall, the dominant theme is hemostasis linked to innate immune defense, warranting a label of coagulation and innate immunity.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007586","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0042127","count":3},{"id":"GO:1903238","count":3}]},{"hash":"1481169186112637915","title":"Glycosphingolipid biosynthesis and immune glycosylation","description":"Most top GO terms point to glycosphingolipid biosynthesis (globoside, MIPC) and glycosylation processes (fucosylation, glycoprotein modification), with immune system terms like leukocyte migration and CD4+ T cell differentiation. Together these suggest a functional cluster around glycan biosynthesis/modification that modulates immune cell interactions; an outlier neural migration term is noted but does not dominate the theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051999","count":5},{"id":"GO:0036210","count":5},{"id":"GO:0001576","count":5},{"id":"GO:0006486","count":4},{"id":"GO:0002361","count":3}]},{"hash":"1067804530057546887","title":"Plant protein acetylation and chromatin regulation","description":"The cluster is dominated by GO terms for various acetylation processes (putrescine, spermidine, N-terminal, peptidyl-lysine) and histone H4 acetylation, plus subtelomeric heterochromatin formation, pointing to a theme of acetylation-driven chromatin modification and regulation. While some plant-specific terms like melatonin biosynthesis and leaf formation regulation appear, the core signal centers on acetylation and chromatin state control.","confidence":"High","size":13,"edges":67,"triangles":220,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":12},{"id":"GO:0030187","count":11},{"id":"GO:0032920","count":11},{"id":"GO:0018003","count":11},{"id":"GO:0032919","count":11}]},{"hash":"1606590868795304751","title":"Hair Follicle Morphogenesis and Keratinization","description":"This cluster is dominated by terms tied to hair follicle development and keratinocyte differentiation (hair follicle morphogenesis and keratinization), with supporting hints from protein homooligomerization and cell\u2013cell adhesion regulation that are common in epidermal structural proteins. A few terms (hatching behavior, aldosterone secretion, Wnt/ERK signaling) are less specific to skin but may reflect broader developmental signaling. Overall, the theme centers on hair follicle formation and keratinization processes.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0035187","count":2},{"id":"GO:0031069","count":2},{"id":"GO:0031424","count":2},{"id":"GO:0034115","count":1}]},{"hash":"511179790443268282","title":"Glutamatergic Synaptic Transmission and Plasticity","description":"The terms center on neuronal communication and learning-related changes: glutamatergic synaptic transmission, regulation of long-term synaptic plasticity, receptor internalization, and memory-associated processes like memory and conditioned taste aversion. This points to a cohesive theme of synaptic signaling and plasticity underlying memory formation, with a few peripheral annotations likely due to broader GO coverage. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072375","count":3},{"id":"GO:0010226","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0001661","count":3},{"id":"GO:0050806","count":3}]},{"hash":"1995477577275592899","title":"Ribosome-translation and protein complex assembly","description":"The cluster is dominated by translation-related GO terms, including mitochondrial translation and ribosomal large subunit assembly, indicating a core role in protein synthesis and ribosome biogenesis. The presence of protein oligomerization terms (homooligomerization/heterooligomerization) supports interactions typical of ribosomal proteins and assembly factors. Some other terms (e.g., metabolic or transcription-related) seem less central, possibly reflecting multifunctionality or annotation noise. Overall, the core theme centers on ribosome-associated translation and assembly.","confidence":"Medium","size":12,"edges":46,"triangles":75,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0032543","count":1},{"id":"GO:0000027","count":1},{"id":"GO:0051289","count":1},{"id":"GO:0055114","count":1}]},{"hash":"878385652875700616","title":"Ribosome biogenesis and kinase signaling","description":"The cluster is dominated by ribosome biogenesis and various protein complex assembly processes (including chaperone-mediated assembly and telomerase assembly), along with regulation and activation of protein kinases. This suggests a core theme of macromolecular assembly and coordinated signaling, with some cytokine-responsive signaling (IL-4) as a secondary note. ","confidence":"Medium","size":12,"edges":16,"triangles":5,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0071353","count":3},{"id":"GO:0071902","count":3},{"id":"GO:0032147","count":3},{"id":"GO:0043524","count":2}]},{"hash":"806838792873400401","title":"Membrane Solute Transporters","description":"This cluster is dominated by membrane transport activities across diverse substrates (nitrite/nitrate, sugars like arabinose and fucose, sialic acid, vitamins) and includes a vesicular neurotransmitter loading term, indicating transporter proteins that move solutes across membranes. The presence of the larval chitin-based cuticle development term may reflect organismal context rather than a shared mechanism, but the overall signal is solute transport.","confidence":"Medium","size":12,"edges":59,"triangles":161,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":6},{"id":"GO:0006004","count":3},{"id":"GO:0042891","count":3},{"id":"GO:0098700","count":3},{"id":"GO:0015707","count":3}]},{"hash":"938377802205904238","title":"Neural differentiation and synaptic cytoskeletal organization","description":"This cluster is dominated by GO terms related to neural development and neuron subtypes (Purkinje cell differentiation, visceral motor neuron differentiation, spinal cord motor neuron fate specification) along with processes tied to synaptic function (exocytosis) and cytoskeletal organization (actin bundle assembly, cell-cell junctions). Some terms like sulfur oxidation and seed morphogenesis are outliers, but the central theme points to neural differentiation and synaptic/cytoskeletal machinery.","confidence":"Medium","size":12,"edges":45,"triangles":93,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0019417","count":4},{"id":"GO:0021702","count":4},{"id":"GO:0045216","count":4},{"id":"GO:0006887","count":4},{"id":"GO:0035195","count":4}]},{"hash":"265845011431406599","title":"Actin filament assembly and regulation","description":"The cluster is dominated by GO terms about actin dynamics\u2014polymerization, nucleation, severing, and capping at barbed and pointed ends\u2014indicating a core theme around actin cytoskeleton organization. A few other, unrelated metabolic terms appear at low frequency, but do not define the cluster. ","confidence":"High","size":12,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030041","count":2},{"id":"GO:0051694","count":2},{"id":"GO:0051014","count":2},{"id":"GO:0045010","count":2},{"id":"GO:0051016","count":2}]},{"hash":"1908092346561814398","title":"Unknown","description":"The protein set shows a broad mix of GO terms across heart electrophysiology, development in both plants and animals, cell cycle processes, cytoskeleton regulation, signaling pathways, mitochondrial calcium signaling, DNA damage response, and host-symbiont interactions. There is no single cohesive function or pathway uniting these terms, indicating heterogeneous or diverse roles rather than a common theme.","confidence":"","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0098911","count":3},{"id":"GO:0060769","count":2},{"id":"GO:0007143","count":2},{"id":"GO:0048364","count":2},{"id":"GO:0080034","count":2}]},{"hash":"98405626382345203","title":"Diverse Transmembrane Transporters","description":"This cluster is dominated by GO terms for transmembrane transport of a wide range of substrates (xenobiotics, vitamins, ions, organic cations, and related molecules), suggesting it groups proteins that function as diverse solute transporters across membranes, rather than a single substrate class.","confidence":"High","size":12,"edges":13,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":12},{"id":"GO:0035461","count":12},{"id":"GO:0071805","count":10},{"id":"GO:0042908","count":10},{"id":"GO:0042891","count":10}]},{"hash":"2239429282848198894","title":"Mitochondrial lipid oxidation and related catabolism","description":"The cluster is dominated by GO terms for fatty acid metabolism, including beta-oxidation via acyl-CoA dehydrogenase, carnitine metabolism, and omega-oxidation, all quintessential mitochondrial lipid catabolic pathways, plus related redox processes and additional catabolic activities. Some terms (tRNA modification, telomere maintenance, proteolysis) may reflect multifunctional proteins or annotation noise, but the core signal centers on mitochondrial lipid breakdown and energy-yielding metabolism. Consider this label as a concise umbrella for these metabolic functions.","confidence":"Medium","size":12,"edges":60,"triangles":168,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:0033539","count":2},{"id":"GO:0009437","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0072670","count":2}]},{"hash":"928042326559215528","title":"Histone methylation and transcription regulation","description":"The GO terms include peptidyl-lysine monomethylation and histone H3-K36 methylation, pointing to epigenetic regulation of transcription. Other terms touch on development and glucocorticoid response, suggesting regulatory programs during development and environmental signaling. The evidence is sparse and connections are indirect, so confidence is Medium.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045184","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0018026","count":1},{"id":"GO:0048642","count":1},{"id":"GO:0071549","count":1}]},{"hash":"1694534035198439938","title":"Glutamatergic Synaptic Transmission and Plasticity","description":"This cluster is dominated by GO terms for glutamatergic synaptic transmission and regulation of long-term neuronal synaptic plasticity, along with memory-related processes (short/medium-term memory, conditioned taste aversion) and receptor internalization. The combination points to proteins involved in excitatory synaptic signaling and plastic changes underlying memory, with ancillary links to neuromodulatory responses (morphine, lithium). Anterior lateral line development may reflect sensory-context aspects but does not override the core synaptic theme.","confidence":"High","size":12,"edges":11,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":6},{"id":"GO:0072375","count":5},{"id":"GO:0010226","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0001661","count":5}]},{"hash":"1711521076863903651","title":"Zinc ion transport and homeostasis","description":"This cluster is characterized by GO terms centered on zinc handling: transmembrane transport of zinc ions, detoxification, intracellular zinc homeostasis, and response to zinc. A few terms about iron/cobalt appear, but the zinc-related terms dominate, suggesting proteins function to regulate zinc levels and detoxify zinc ions. Therefore the label zinc ion transport and homeostasis captures the main shared function.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071577","count":1},{"id":"GO:0032119","count":1},{"id":"GO:0071584","count":1},{"id":"GO:0010312","count":1},{"id":"GO:0006882","count":1}]},{"hash":"200184812904853063","title":"Unknown","description":"The cluster\u2019s top GO terms span several distinct themes: membrane-associated phosphate transport, multiple signaling pathways (Wnt, ephrin receptor), neuronal development (axonal fasciculation), post-translational ADP-ribosylation, and telomere maintenance. This heterogeneity makes it hard to identify a single cohesive function tying the proteins together, so a specific, unified label isn\u2019t apparent.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035435","count":2},{"id":"GO:0016055","count":2},{"id":"GO:1904908","count":2},{"id":"GO:1904743","count":2},{"id":"GO:0007205","count":2}]},{"hash":"598350929654352108","title":"Cardiovascular signaling and endothelial angiogenesis","description":"This cluster centers on cardiac signaling (regulation of SA node action potential, GPCR pathways) and endothelial/vascular development (sprouting angiogenesis, venous differentiation), with supporting involvement from Wnt signaling and inflammatory responses, suggesting a cohesive cardiovascular-vascular regulatory theme.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098907","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0048265","count":3},{"id":"GO:1903589","count":2},{"id":"GO:1901594","count":2}]},{"hash":"1534537884410820003","title":"Calcium-Dependent Neurotransmitter Release","description":"These proteins cluster around neuronal neurotransmission and calcium signaling: regulation of dopamine secretion, fast Ca2+-dependent exocytosis of neurotransmitter, and GABA signaling. Store-operated calcium channel activity and IP3 biosynthesis further point to Ca2+ dynamics governing vesicle fusion. Some terms like ribophagy and IL-12 production may reflect broader roles or annotation noise, but the core signal is neurotransmitter release driven by calcium. ","confidence":"Medium","size":12,"edges":12,"triangles":3,"max_degree":4,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0014059","count":3},{"id":"GO:1900122","count":3},{"id":"GO:0098746","count":3},{"id":"GO:0032735","count":3},{"id":"GO:0032237","count":3}]},{"hash":"1461996205238214690","title":"Embryonic heart and placental development with signaling regulation","description":"This cluster centers on developmental processes linking heart and placental formation, including heart development and various placental development terms, plus cell migration and tissue remodeling. The presence of GO terms related to GPCR signaling desensitization and JNK cascade regulation suggests coordinated signaling control during embryogenesis. While some terms (e.g., B cell maturation) are immune-specific or general stress responses, the dominant theme ties to embryonic tissue development and its regulation by signaling pathways.","confidence":"Medium","size":12,"edges":13,"triangles":1,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0010765","count":4},{"id":"GO:0009636","count":3},{"id":"GO:0002029","count":3},{"id":"GO:0002344","count":3}]},{"hash":"1029427360946749810","title":"Transcriptional Regulation and Immune/Cardiac Differentiation","description":"The top GO terms point to transcriptional control by RNA polymerase II (including miRNA transcription) and to differentiation of several lineages (myeloid dendritic cells, lymphoid progenitors, erythrocytes) as well as cardiac-related development (endocardial cushion). This suggests a cluster of proteins involved in regulating gene expression that guides diverse lineage differentiation, spanning immune, hematopoietic, and cardiac programs. The lack of interactions does not negate a shared regulatory theme centered on transcriptional control linked to differentiation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:1901407","count":2},{"id":"GO:1900126","count":2},{"id":"GO:0043011","count":2},{"id":"GO:0003197","count":2}]},{"hash":"1933511971710667813","title":"Unknown","description":"The top GO terms span wildly different biological domains, including mammalian immune/coagulation processes (complement activation, blood coagulation, prostaglandin catabolic), plant development (secondary shoot formation; regulation of vessel diameter), and various metabolism pathways (biotin and methionine biosynthesis, nitrogen utilization, beta-ketoadipate pathway). With no clear, single shared function linking these proteins, there isn\u2019t a cohesive theme to name the cluster beyond Unknown.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0009102","count":3},{"id":"GO:0009086","count":3},{"id":"GO:1905344","count":3}]},{"hash":"1603944987275345653","title":"Unknown","description":"Top terms are diverse, including transcription regulation by RNA Pol II, midbrain development, immune responses, coagulation, elastin catabolism, digestion, and Wnt signaling; these do not converge on a single coherent function for the cluster. ","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0030901","count":6},{"id":"GO:0042127","count":5},{"id":"GO:1903238","count":5}]},{"hash":"2026697224521097323","title":"Unknown","description":"The top GO terms are highly diverse, including brown fat differentiation, fatty acid oxidation, aldosterone secretion, eye morphogenesis, coagulation, and various signaling/regulatory processes, with no single unifying function tying the proteins together. The absence of edges/triangles and the scattered themes suggest no cohesive high-level role for this cluster beyond a heterogeneous collection of functions. ","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050873","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0048593","count":3},{"id":"GO:0034115","count":2},{"id":"GO:0033034","count":2}]},{"hash":"1511117809580027227","title":"mRNA processing and translation initiation","description":"This cluster is characterized by GO terms tied to translation initiation (eIF4F complex assembly, preinitiation complex formation, regulation of translational initiation) and various RNA processing steps (mRNA stabilization, splice-site recognition, spliceosome-mediated splicing). Together these suggest a cohesive role in preparing and regulating mRNA for translation. ","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097010","count":2},{"id":"GO:0010610","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0006446","count":2}]},{"hash":"535586884203060381","title":"Chromatin remodeling and cell division regulators","description":"This cluster's top GO terms cluster around chromatin dynamics (nucleosome assembly/disassembly, histone acetylation regulation) and cell division processes (stem cell division regulation, microtubule polymerization, sperm DNA decondensation, budding), suggesting a theme of chromatin remodeling linked to cell division. While there are also general terms like protein transport, the recurring chromatin- and division-related terms support this label.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000035","count":2},{"id":"GO:0006337","count":1},{"id":"GO:0006334","count":1},{"id":"GO:0031116","count":1},{"id":"GO:0015031","count":1}]},{"hash":"326678483986618815","title":"NMDA receptor signaling in spinal cord development","description":"The cluster shows enrichment for NMDA receptor\u2013related terms (NMDA glutamate receptor clustering, regulation of NMDA receptor activity, positive regulation of excitatory postsynaptic potential) together with spinal cord development/patterning terms, suggesting a cohesive function in NMDA receptor\u2013dependent synaptic signaling during spinal cord development and associated nociceptive signaling. Some terms related to inflammatory responses and pain are present but seem secondary to the core NMDA/spinal circuitry theme.","confidence":"High","size":11,"edges":45,"triangles":112,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0048265","count":1}]},{"hash":"23537082087047776","title":"Membrane trafficking and mitochondrial dynamics","description":"This cluster centers on membrane-associated processes and mitochondrial function: terms such as inner mitochondrial membrane organization, mitochondrial membrane potential, and stress-induced mitochondrial fusion point to mitochondrial dynamics, while protein localization to membrane rafts and SREBP signaling relate to membrane organization and lipid signaling. Other terms like positive regulation of cell adhesion molecule production and metanephric podocyte development suggest membrane/cell-surface dynamics in specialized cell types, and ubiquitin-dependent ERAD pathway plus excretion reflect membrane-anchored protein quality control and transport. Overall, the common theme is interplay between membrane organization and mitochondrial dynamics shaping cellular trafficking and signaling.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0060355","count":10},{"id":"GO:0010918","count":10},{"id":"GO:0072249","count":10},{"id":"GO:0032623","count":10},{"id":"GO:1903044","count":10}]},{"hash":"995588146221870344","title":"Histone Deacetylation and Transcriptional Silencing","description":"The top GO terms cluster around chromatin regulation and transcriptional repression, especially histone deacetylation (HDAC activity), heterochromatin maintenance, and repression of RNA transcription (including miRNA transcription). This points to a module of chromatin-modifying enzymes and repressors that compact chromatin and silence transcription, with some related lineage- or signaling-specific regulatory roles. A minor note: aggresome assembly appears but does not change the core chromatin-centric theme.","confidence":"High","size":11,"edges":44,"triangles":91,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0060766","count":6},{"id":"GO:0045668","count":6},{"id":"GO:0070932","count":6},{"id":"GO:0070842","count":5}]},{"hash":"1814922338211883856","title":"Calcium signaling in neural and muscular contexts","description":"The cluster\u2019s GO terms point to calcium ion regulation and signaling, including mitochondrial calcium concentration, regulation of cardiac muscle contraction via calcium release, axonogenesis, and astrocyte differentiation, suggesting a shared theme of calcium dynamics in neural and muscle-related processes. Some terms (mitotic cycle, surfactant homeostasis, bioluminescence, digestion) appear less connected, indicating annotation noise but not overshadowing the calcium-centric pattern.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0043129","count":2},{"id":"GO:0008218","count":2},{"id":"GO:0007409","count":2},{"id":"GO:0051343","count":2}]},{"hash":"1241234657616356249","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":53,"triangles":148,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0090502","count":2},{"id":"GO:0001966","count":1},{"id":"GO:0061055","count":1},{"id":"GO:0042226","count":1},{"id":"GO:0010738","count":1}]},{"hash":"353287075290625504","title":"Kidney development and immune response cluster","description":"These GO terms cluster into two main themes: kidney development (mesonephric duct development; metanephric distal tubule morphogenesis) and immune/stress responses (phagocytosis recognition; basophil activation; cellular response to fungal origin; ROS regulation; oxidative stress-induced senescence). The combination suggests proteins involved in renal morphogenesis along with innate immune or oxidative stress signaling, so the label is a concise representation of the dominant themes. Some terms (e.g., learning, cartilage condensation) are less clearly connected and may reflect broader annotations or pleiotropy.","confidence":"Medium","size":11,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2000378","count":3},{"id":"GO:0007612","count":3},{"id":"GO:0001502","count":3},{"id":"GO:0060355","count":3},{"id":"GO:0006910","count":3}]},{"hash":"1173071877642929574","title":"Opioid- and dopamine-mediated neural signaling in sensory processing","description":"These proteins cluster around opioid and dopaminergic signaling and broader neuronal communication, as indicated by responses to morphine and amphetamine, regulation of dopamine secretion, and GPCR pathway modulation. The inclusion of sensory and visual system terms (regulation of sensory perception of pain, photoreceptor maintenance, visual learning) suggests involvement in CNS sensory processing and synaptic transmission, including glutamatergic signaling. Overall, the cluster likely represents proteins functioning in neuromodulatory signaling that shapes sensory perception and synaptic activity.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":4},{"id":"GO:0060134","count":3},{"id":"GO:0001975","count":3},{"id":"GO:0051930","count":3},{"id":"GO:0008542","count":3}]},{"hash":"390567018199619433","title":"Developmental transcription and neural specification","description":"Based on top GO terms, the cluster is enriched for transcriptional processes (DNA-templated transcription; RNA polymerase II transcription) and developmental pathways (somitogenesis; embryonic heart tube formation; spinal cord motor neuron cell fate specification; negative regulation of astrocyte differentiation). The presence of integrin-mediated cell adhesion also supports morphogenesis. Together these suggest a coherent theme of transcriptional regulation guiding developmental and neural differentiation. Some terms about cellular responses to lithium/oleic acid point to signaling contexts but do not define the core function.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:2001038","count":5},{"id":"GO:0006366","count":5},{"id":"GO:0048712","count":5},{"id":"GO:0001756","count":5}]},{"hash":"2266624196507118458","title":"Podocyte development and mitochondrial membrane dynamics","description":"This cluster centers on podocyte biology (metanephric podocyte development, excretion, cell adhesion) and concurrent mitochondrial/membrane dynamics (inner mitochondrial membrane organization, mitochondrial membrane potential, stress-induced fusion, membrane raft localization), suggesting a coordinated role of kidney podocyte function with mitochondrial and membrane processes. Lipid metabolism and ER-associated quality control terms provide supportive context but are secondary to the core podocyte\u2013mitochondrial theme.","confidence":"Medium","size":11,"edges":13,"triangles":4,"max_degree":10,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0060355","count":3},{"id":"GO:0010918","count":3},{"id":"GO:0072249","count":3},{"id":"GO:0032623","count":3},{"id":"GO:1903044","count":3}]},{"hash":"2254063278770754106","title":"Neural development and energy metabolism","description":"This cluster\u2019s top GO terms cluster into two related themes: neural development (striatum, cerebellar cortex, thalamus development) and core cellular metabolism (glycolytic and glucose metabolic processes, TCA cycle). This suggests a set of proteins involved in brain development with concurrent roles in energy production and carbohydrate metabolism, which are tightly linked during neurodevelopment. Some terpenoid/xylulose biosynthesis terms may reflect broader metabolic annotations or indirect links but do not outweigh the neural-development-centric signal.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021756","count":4},{"id":"GO:0006099","count":4},{"id":"GO:0046166","count":3},{"id":"GO:0021695","count":3},{"id":"GO:0006096","count":3}]},{"hash":"960840764421471451","title":"Cardiac muscle development and adrenergic signaling","description":"The top terms cluster around cardiac muscle development and function (skeletal and cardiac muscle fiber development, regulation of heart contraction, and calcium-mediated contraction regulation) plus adrenergic signaling (cellular response to epinephrine) and related cardiac signaling (Purkinje to ventricular pathways). Some terms like skin/cuticle and memory are present but appear as noise; overall the strongest shared theme is heart muscle development and contraction regulation. ","confidence":"Medium","size":11,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0010881","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0098735","count":2},{"id":"GO:0071872","count":2}]},{"hash":"1153188800981905613","title":"Neuronal Plasticity with Epigenetic Regulation","description":"The cluster is dominated by GO terms tied to activity-dependent synaptic changes (long-term depression and potentiation) and chromatin remodeling/nucleosome disassembly, pointing to epigenetic control of gene expression during neural plasticity. Additional terms related to social behavior and intracellular trafficking (endosome/ER localization) suggest neuronal signaling and receptor dynamics at synapses. Together these indicate a cohesive theme of neuronal plasticity modulated by chromatin-level regulation and protein trafficking, though some terms are less directly tied. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036010","count":2},{"id":"GO:0043044","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0006337","count":2},{"id":"GO:0060292","count":2}]},{"hash":"1653244588317177656","title":"Developmental growth signaling regulators","description":"These proteins are linked to broad developmental processes (skeletal system development, neural tube closure, male gonad development, multicellular organism development and growth) and to signaling/regulatory activities (positive regulation of GTPase activity, negative regulation of protein tyrosine kinase activity, regulation of cell cycle checkpoint). Together they suggest a cluster of factors that modulate developmental signaling pathways and growth during organogenesis.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0001501","count":5},{"id":"GO:0008584","count":5},{"id":"GO:0001843","count":5},{"id":"GO:0010255","count":5},{"id":"GO:0070208","count":5}]},{"hash":"2043739471121588392","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051123","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0060325","count":1},{"id":"GO:0007406","count":1},{"id":"GO:0031564","count":1}]},{"hash":"1056807260692608398","title":"Protein quality control and signaling regulation","description":"This cluster centers on regulation of cellular processes through protein modification and degradation (sumoylation, ERAD) and modulation of signaling pathways (negative regulation of TLR3 signaling and GPCR internalization), complemented by links to cell-cycle and repair processes. The recurring theme is proteostasis-related regulation and signaling control, despite some diverse or obsolete terms, suggesting a coherent focus on how cells regulate proteins and signals to maintain homeostasis.","confidence":"Medium","size":11,"edges":53,"triangles":147,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0034140","count":10},{"id":"GO:0033132","count":10},{"id":"GO:0030433","count":10},{"id":"GO:0014070","count":10},{"id":"GO:0016925","count":10}]},{"hash":"2232742452834106937","title":"Neuronal development and immune signaling","description":"The cluster features axonogenesis and actin cytoskeleton remodeling along with GPCR desensitization, T cell receptor signaling, and mast cell cytokine production, suggesting coordinated neural development and immune signaling through shared receptor and cytoskeletal pathways; additional terms on synaptic plasticity regulation and apoptosis reinforce a neural-immune regulatory theme, with one lipid metabolism term as a possible outlier.","confidence":"Medium","size":11,"edges":52,"triangles":139,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031532","count":11},{"id":"GO:0007409","count":11},{"id":"GO:0010898","count":11},{"id":"GO:0032092","count":11},{"id":"GO:0050852","count":11}]},{"hash":"1750408472353650896","title":"Immune activation and NK cell regulation","description":"The GO terms highlight adaptive immune response, regulation of NK cell activity and cytotoxicity, cytokine signaling (IL-2), phagocytosis, and hypersensitivity, suggesting the proteins function together in immune activation and control of NK-mediated responses, despite a few outlier terms that may reflect annotation noise.","confidence":"High","size":11,"edges":10,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":1},{"id":"GO:0021628","count":1},{"id":"GO:0002859","count":1},{"id":"GO:0002519","count":1},{"id":"GO:0006911","count":1}]},{"hash":"483724046074987320","title":"Unknown","description":"The terms are broad and cover immune signaling (complement activation, myeloid/granulocyte regulation), endocrine/hormone processes (aldosterone secretion, renal albumin absorption), oxidative stress sensing, and general signaling (PKA activity, synapse assembly, protein heterotrimerization). With no edges, there is no clear shared mechanism tying these proteins into a single coherent function, so a single descriptive label cannot be reliably assigned.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033034","count":2},{"id":"GO:2000860","count":2},{"id":"GO:0070994","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0030853","count":2}]},{"hash":"256922094818673518","title":"Neural development and immune signaling","description":"The terms point to neural development (axonogenesis; cerebellum morphogenesis) plus cell\u2013cell signaling and growth, with accompanying immune-related processes (adaptive immune response) and signaling pathways (ERK regulation, apoptotic signaling). This suggests a module where neural development is coordinated with immune signaling and apoptotic pathways, potentially reflecting neuroimmune interactions during brain development.","confidence":"Medium","size":11,"edges":27,"triangles":29,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":11},{"id":"GO:0031532","count":9},{"id":"GO:0070373","count":9},{"id":"GO:0002250","count":9},{"id":"GO:0007409","count":9}]},{"hash":"1833281124676680479","title":"Methylation- and biosynthesis-related enzymes","description":"The top GO terms are dominated by various methylation processes (peptidyl-arginine methylation, asymmetrical dimethyl arginine, N-terminal alanine trimethylation, tRNA methylation, histone methylation) and a mRNA capping event, alongside biosynthetic processes (biotin and sterol biosynthesis). This suggests a core theme around methyltransferase activities and related biosynthetic pathways, with additional broad signals like xenobiotic response and nodulation that may reflect broader regulatory roles. Confidence: Medium","confidence":"","size":11,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0009102","count":5},{"id":"GO:0043985","count":5},{"id":"GO:0006370","count":5},{"id":"GO:0018012","count":5},{"id":"GO:0016126","count":5}]},{"hash":"1098785113237064620","title":"Wnt signaling and immune-vascular remodeling","description":"The top GO terms point to a core of Wnt signaling together with processes tied to vascular and immune interfaces, including regulation of endothelial barrier, leukocyte tethering, and neutrophil activity, alongside tissue remodeling (elastin catabolism) and coagulation (Factor XII activation). While digestion and growth terms are broader, the prevailing pattern suggests a cluster centered on signaling that links development/proliferation with immune cell recruitment and vascular remodeling. Confidence: Medium","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":10},{"id":"GO:0042127","count":9},{"id":"GO:1903238","count":9},{"id":"GO:0060309","count":9},{"id":"GO:0002542","count":9}]},{"hash":"871488865761792533","title":"Glycan biosynthesis and leukocyte migration","description":"The top GO terms cluster around glycosylation and glycan biosynthesis (Lewis a epitope biosynthesis, N-glycan fucosylation, protein glycosylation) and immune cell movement (leukocyte migration involved in immune response), suggesting the proteins are involved in glycan assembly on immune-related proteins and in leukocyte trafficking. A few terms (neuronal migration, testosterone response, pain response) are present but appear less central to the cluster\u2019s main theme, possibly reflecting secondary roles or annotation nuance.","confidence":"Medium","size":11,"edges":11,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002361","count":1},{"id":"GO:0006486","count":1},{"id":"GO:0010493","count":1},{"id":"GO:0002522","count":1},{"id":"GO:0036071","count":1}]},{"hash":"620709657631861086","title":"Unknown","description":"GO terms are highly heterogeneous and include several obsolete terms; no single unifying function stands out (nuclear transport, cell division, intraciliary transport, synaptic plasticity, lens differentiation, viral mRNA export), so a coherent cluster theme cannot be assigned.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0031081","count":3},{"id":"GO:0035721","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0051441","count":3}]},{"hash":"2224252224834853888","title":"Immune signaling and leukocyte migration","description":"The cluster prominently features terms related to immune activity, including leukocyte migration involved in immune response and regulatory T cell differentiation, pointing to a primary theme of immune signaling and trafficking. Supporting terms touch on immune-related stress responses (cellular response to xenobiotic stimulus, nitric oxide, calcium ion) and glycan/epitope biosynthesis (Lewis a epitope biosynthetic process), which can accompany immune functions. Some metabolic terms are present, but the dominant signal centers on immune cell function and movement.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":2},{"id":"GO:0031457","count":2},{"id":"GO:0050667","count":2},{"id":"GO:0071732","count":2},{"id":"GO:0006508","count":2}]},{"hash":"174284265921879505","title":"Receptor signaling and actin remodeling","description":"The top GO terms point to signaling initiated by membrane receptors (insulin receptor, epidermal growth factor response, GPCR internalization) that converge on actin cytoskeleton dynamics (actin organization, filopodium assembly) and small GTPase pathways, with notes on phosphoinositide regulation and vesicle trafficking (dense core granule exocytosis). Together, these terms suggest a cohesive theme of receptor-driven signaling leading to cytoskeletal remodeling and membrane trafficking.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0071364","count":2},{"id":"GO:0007264","count":1}]},{"hash":"2156221270666516070","title":"Mitochondrial energy metabolism and metal homeostasis","description":"The cluster centers on mitochondrial processes: assembly of respiratory chain complex IV, ATP regulation, redox homeostasis, and copper/heme cofactor pathways. Copper ion transport and intracellular copper homeostasis support cytochrome c oxidase function, while heme biosynthesis and mitochondrial translation fit with mitochondrial biology, suggesting a cohesive theme of mitochondrial energy metabolism and metal cofactor management. Some terms (erythrocyte differentiation, oocyte construction) are less directly related but do not override the core mitochondrial signal.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008535","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0007308","count":1},{"id":"GO:0006825","count":1},{"id":"GO:0045454","count":1}]},{"hash":"1086561860105904114","title":"Receptor-Mediated Immune and Neural Development Signaling","description":"The cluster combines GO terms for toll-like receptor signaling, cytokine signaling, GPCR and receptor tyrosine kinase pathways, pointing to a shared theme of cell-surface receptor\u2013driven signaling. The presence of axonogenesis and otolith morphogenesis links these signaling activities to developmental processes (neural and sensory systems). Overall, proteins here seem to participate in diverse but related signaling networks governing development and immune responses.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007169","count":5},{"id":"GO:0034134","count":5},{"id":"GO:0007409","count":5},{"id":"GO:0090141","count":5},{"id":"GO:1900155","count":5}]},{"hash":"1690255509452874471","title":"Cytoskeleton dynamics and vesicle trafficking","description":"The top terms point to cytoskeleton organization (microtubule anchoring; regulation of Rho signaling) and vesicle trafficking processes (vesicle targeting and tethering), suggesting a cohesive theme of cytoskeletal coordination with membrane trafficking. A few terms (tRNA processing, placental proliferation) are less connected and may reflect annotation noise, but the core theme remains cytoskeleton\u2013vesicle dynamics.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034453","count":1},{"id":"GO:0030307","count":1},{"id":"GO:0031532","count":1},{"id":"GO:0008033","count":1},{"id":"GO:0006903","count":1}]},{"hash":"661504500630799734","title":"mRNA splicing and translation initiation regulation","description":"The top GO terms center on spliceosome-mediated mRNA processing (mRNA splicing via spliceosome, splice site recognition), regulation of mRNA stability in response to stress, and assembly/regulation of translation initiation complexes (preinitiation complex formation, eIF4F complex assembly, regulation of translational initiation), with a nod to regulatory ncRNA-mediated gene silencing. This pattern points to a coherent module where RNA processing and manipulation of translation initiation are linked, justifying a label that highlights both splicing and translation initiation control.","confidence":"High","size":10,"edges":43,"triangles":105,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0048026","count":6},{"id":"GO:0097010","count":5},{"id":"GO:0010610","count":5}]},{"hash":"1488408941150235963","title":"Neurodevelopmental transcriptional regulation","description":"The cluster is dominated by GO terms related to nervous system and forebrain development and neuron apoptotic processes, along with diverse transcriptional regulation by RNA polymerase II and associated epigenetic modulation (including histone methylation). This points to proteins that function as transcriptional regulators and chromatin modifiers shaping neural development, with a cohesive neural-focus theme despite a few broader context terms.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030900","count":2},{"id":"GO:0051402","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0061087","count":2}]},{"hash":"763373332170122128","title":"GPCR Signaling and Dopamine Regulation","description":"The terms center on G protein-coupled receptor signaling, including adenylate cyclase activation/inhibition, PLC-activating adrenergic pathways, receptor internalization, and arrestin-related desensitization, with dopamine secretion regulation and photoreceptor maintenance suggesting retinal GPCR roles. An outlier term (electron transport chain) does not change the overall GPCR-centric theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":10},{"id":"GO:0022900","count":10},{"id":"GO:0007190","count":10},{"id":"GO:0010579","count":10},{"id":"GO:0031635","count":8}]},{"hash":"974088042287105689","title":"Developmental and inflammatory signaling","description":"The Top Terms show involvement in organ development (heart, lung) alongside inflammatory mediator production and chemokine/IL-8 signaling, with additional apoptosis and mechanotransduction hints. While some metabolic terms (chitin and polysaccharide catabolic processes) appear as noise, the dominant pattern points to development-related and immune-modulatory functions.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0006032","count":3},{"id":"GO:0002532","count":3},{"id":"GO:0005975","count":3}]},{"hash":"1531651375655108269","title":"Neuronal vesicle exocytosis and brain development","description":"This cluster is strongly defined by terms tied to neuronal communication and development: regulation of synaptic vesicle exocytosis, fast calcium-dependent neurotransmitter release, and dopamine secretion, along with brain development. These together imply a group of proteins involved in synaptic transmission and neuronal maturation, with a few unrelated or deprecated terms present as noise. ","confidence":"High","size":10,"edges":35,"triangles":56,"max_degree":8,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0010796","count":4},{"id":"GO:0043087","count":4},{"id":"GO:2000300","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0031384","count":4}]},{"hash":"1411107309359682906","title":"Translation Machinery and Ribosome Biogenesis","description":"Most GO terms cluster around translation and ribosome assembly/processing (translation, ribosome biogenesis, initiation, termination, positive regulation of elongation, cytoplasmic translation, selenocysteine incorporation, and mRNA decay linked to translation). A few terms like glial cell proliferation or antibiotic response can be secondary connections to translation regulation or ribosome-targeting antibiotics, but the dominant signal is protein synthesis machinery. Confidence: High","confidence":"","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":9},{"id":"GO:0046677","count":4},{"id":"GO:0042254","count":3},{"id":"GO:0006413","count":3},{"id":"GO:0006415","count":3}]},{"hash":"676574419462181709","title":"Starch and Sugar Biosynthesis under Water Stress","description":"The cluster is enriched for carbohydrate biosynthesis terms (starch, sucrose, glycogen, glucose) and includes stress-response terms for water deprivation and flooding, suggesting a group of proteins involved in storage carbohydrate production linked to abiotic stress in plants; a minor association with GPI-anchor biosynthesis reflects glycoprotein processing but is not central.","confidence":"Medium","size":10,"edges":39,"triangles":79,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0019252","count":3},{"id":"GO:0005985","count":3},{"id":"GO:0005978","count":3},{"id":"GO:0009414","count":2},{"id":"GO:0006506","count":2}]},{"hash":"488796761211373881","title":"Microtubule-Driven Nuclear Migration and Cytokinesis","description":"The top GO terms cluster around microtubule-based processes: nuclear migration along microtubules, spindle midzone assembly, and cytokinesis by cell plate formation, plus axonemal microtubule dynamics and chloroplast movement, indicating a shared theme of microtubule-guided transport and structural rearrangements during cell division and organelle positioning. Some terms reflect broader microtubule-dependent transport and developmental processes, reinforcing a cohesive microtubule-centered interpretation.","confidence":"High","size":10,"edges":39,"triangles":81,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0030473","count":10},{"id":"GO:0048364","count":10},{"id":"GO:0060404","count":10},{"id":"GO:0000911","count":10},{"id":"GO:0009904","count":10}]},{"hash":"1867147747121072261","title":"Steroid hormone metabolism and pigment biosynthesis","description":"This cluster centers on steroid pathways (androgen, glucocorticoid, and C21-steroid hormone metabolism) and pigment-related processes (retinal and melanin biosynthesis), with supporting lipid metabolism signals (fatty acid elongation) and plant secondary metabolism (tropane alkaloid biosynthesis). The shared theme is steroid hormone metabolism coupled with pigment biosynthesis, suggesting a cohesive metabolic module. ","confidence":"Medium","size":10,"edges":42,"triangles":99,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008209","count":10},{"id":"GO:0006710","count":10},{"id":"GO:0006729","count":10},{"id":"GO:0042574","count":10},{"id":"GO:0006704","count":10}]},{"hash":"542753983437143959","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034975","count":8},{"id":"GO:0045454","count":8},{"id":"GO:0097428","count":5},{"id":"GO:0036494","count":5},{"id":"GO:0030433","count":5}]},{"hash":"1294267694611175916","title":"Developmental Growth and Transcription Regulation","description":"This cluster is dominated by terms about organismal development and transcription control, including multicellular organism growth, pancreas morphogenesis, and DNA-templated transcription plus positive/negative regulation of RNA polymerase II\u2013driven transcription. A few immune/coagulation terms appear (leukocyte tethering, neutrophil killing of fungus, Factor XII activation) but are less representative of the core theme, which centers on developmental growth linked to transcriptional regulation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035264","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0061113","count":3},{"id":"GO:0045944","count":3}]},{"hash":"2217153472633660287","title":"Nuclear transcription and mRNA export","description":"This cluster is dominated by GO terms tied to nuclear gene expression: DNA-templated transcription, chromatin-related histone methylation, and poly(A)+ mRNA export from the nucleus, plus a term about tethering RNA Pol II to DNA at the nuclear periphery. While a few terms touch on broader cellular transport processes, the core signals point to transcriptional regulation and RNA processing within the nucleus.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015031","count":2},{"id":"GO:0045956","count":1},{"id":"GO:0045806","count":1},{"id":"GO:0050715","count":1},{"id":"GO:0006351","count":1}]},{"hash":"1735594556085513550","title":"Growth and cell cycle regulation","description":"Growth and cell cycle regulation. The top GO terms center on controls of cell proliferation, including regulation of cell cycle checkpoints, cell division, and multicellular organism growth, with supporting processes like ribosome biogenesis and actin nucleation that enable growth and division. Developmental and metabolic signaling terms (forebrain development, SREBP pathway) suggest a broader growth-regulation theme in multicellular contexts. Confidence: Medium.","confidence":"","size":10,"edges":6,"triangles":0,"max_degree":6,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0061099","count":8},{"id":"GO:1901976","count":8},{"id":"GO:0035264","count":8},{"id":"GO:0030433","count":8},{"id":"GO:0031081","count":8}]},{"hash":"1909070957179099114","title":"Translation Initiation Machinery","description":"Dominant GO terms center on translation initiation and assembly of initiation machinery (translation, preinitiation complex formation, eIF4F complex assembly), indicating proteins involved in starting protein synthesis. While a few terms hint at stress-related mRNA stability and development, the core signal is initiation of translation, justifying the label as a cohesive translation initiation cluster.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0001731","count":2},{"id":"GO:0006413","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0035264","count":2}]},{"hash":"1099597327871728884","title":"Ubiquitin-mediated proteolysis","description":"The cluster's strongest signals are ubiquitination and ubiquitin-dependent degradation, including autoubiquitination, K63-linked ubiquitination, and ERAD pathways, indicating proteins involved in marking substrates for proteasomal turnover. A few terms like photosynthesis and synapse maturation are present but less reflective of the core function.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":4},{"id":"GO:0042787","count":3},{"id":"GO:0070534","count":3},{"id":"GO:1903762","count":3},{"id":"GO:1901253","count":3}]},{"hash":"1556205466636376419","title":"Neuronal signaling and ion transport","description":"The cluster centers on neural signaling and sensory transduction. Frequent terms include sodium and potassium ion transmembrane transport, membrane depolarization, excitatory postsynaptic potential, and GABA signaling, indicating synaptic activity. Additional terms related to inner ear receptor cell development and response to amino acids link to sensory processing and neurotransmission, with behavioral terms like locomotory behavior and righting reflex suggesting neural circuit function. Overall, a cohesive theme of neuronal signaling and sensory processing.","confidence":"High","size":10,"edges":12,"triangles":3,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":10},{"id":"GO:0001661","count":9},{"id":"GO:0007214","count":9},{"id":"GO:0060079","count":9},{"id":"GO:0035725","count":9}]},{"hash":"1441727661628862612","title":"Iron Transport and Detoxification","description":"The cluster shows strong GO terms for iron handling: siderophore-iron import, iron ion transport, detoxification of iron ion, and related redox processes (oxidation-reduction, succinate dehydrogenase activity). While chromosome condensation and regulation of fibroblast proliferation appear, the iron-related terms dominate, pointing to a function in iron uptake and iron detoxification.","confidence":"High","size":10,"edges":11,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:1904231","count":2},{"id":"GO:0006950","count":2},{"id":"GO:0006880","count":2},{"id":"GO:0033214","count":2}]},{"hash":"1518372930084537082","title":"Unknown","description":"These GO terms span a very diverse set of processes\u2014from ribosome biogenesis and cell division to pigment biosynthesis and morphogenesis\u2014with additional nutrient and stimulus responses. The lack of connections (0 edges) among proteins suggests there is no cohesive, interpretable function tying the cluster together, so a neutral, Unknown label is most appropriate.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007584","count":3},{"id":"GO:0000747","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0055072","count":2}]},{"hash":"917682194065147806","title":"Developmental Tissue Differentiation Proteins","description":"Top GO terms here converge on tissue development and differentiation across multiple organs (skin, forebrain, lens, skeletal) and general multicellular development, along with protein complex assembly (homooligomerization/heterotrimerization). This pattern suggests a cohesive theme of morphogenesis and structural protein interactions during development, rather than a single concrete signaling pathway. The lack of edges does not negate the shared developmental function indicated by the GO terms.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051260","count":5},{"id":"GO:0043588","count":5},{"id":"GO:0070208","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0030900","count":3}]},{"hash":"1422921948338533913","title":"Unknown","description":"The Top Terms show a highly heterogeneous mix: DNA replication and recombination alongside pollen and cuticle development, chitin metabolism, lung development, immune signaling, and mechanical stimulus responses. There is no single shared function or pathway that ties the proteins together, and with no observed edges, a cohesive cluster label cannot be assigned.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006048","count":2},{"id":"GO:0009555","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0007131","count":2}]},{"hash":"2201946219249566851","title":"Unknown","description":"GO terms span sarcomere organization, immune signaling (dendritic cell differentiation, B cell receptor signaling, complement activation), nervous system development and synapse assembly, paranodal junction assembly, and ammonium transport. There is no single shared function apparent across these terms, and the proteins show no edges, suggesting they participate in unrelated processes or reflect annotation noise. Therefore a cohesive label is not possible.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":3},{"id":"GO:2001200","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0030913","count":2}]},{"hash":"741958678155895463","title":"Mitochondrial respiration and energy metabolism","description":"The top GO terms are dominated by mitochondrial electron transport (ubiquinol to cytochrome c), proton transmembrane transport, and aerobic respiration, all central to mitochondria-driven energy production. Additional terms reference general transport and mitochondrial protein targeting/processing, supporting a mitochondrion-centric functional theme. Some incidental terms relate to signaling and lifespan, which can reflect downstream metabolic regulation but do not override the core mitochondrial energy focus. Overall, the cluster seems best described by mitochondrial respiration and energy metabolism.","confidence":"High","size":9,"edges":18,"triangles":16,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006122","count":3},{"id":"GO:1902600","count":3},{"id":"GO:0009060","count":3},{"id":"GO:0006810","count":1},{"id":"GO:0019684","count":1}]},{"hash":"971998508100581678","title":"Neural differentiation and epigenetic regulation","description":"The cluster shows several neural-development related terms (neuron maturation, neuron projection extension) alongside themes of transcriptional control and epigenetic regulation (negative regulation of transcription by RNA polymerase II, histone H3-K4 demethylation), and proliferative/differentiation capacity (positive regulation of stem cell proliferation, differentiation-related signals like megakaryocyte differentiation). Metabolic terms (tetrahydrofolate and guanine metabolic processes) support nucleotide synthesis needed for proliferation and differentiation, tying the cluster to differentiation with epigenetic and transcriptional governance.","confidence":"Medium","size":9,"edges":30,"triangles":53,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045654","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0042551","count":4},{"id":"GO:0046653","count":4},{"id":"GO:0046886","count":4}]},{"hash":"230533697000667987","title":"Fatty acid oxidation and ketone body synthesis","description":"The cluster is enriched for fatty acid beta-oxidation, acetyl-CoA catabolic processes, medium-chain fatty acid biosynthesis, and ketone body biosynthesis, all pointing to lipid energy metabolism. Additional terms like response to starvation and adipose tissue development reinforce a theme of energy regulation and lipid handling, suggesting these proteins function together in lipid catabolism and ketogenesis as part of metabolic adaptation. ","confidence":"High","size":9,"edges":28,"triangles":42,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0014070","count":6},{"id":"GO:0006635","count":4},{"id":"GO:0060612","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0051792","count":4}]},{"hash":"2273462460260139765","title":"Developmental signaling and cytoskeletal dynamics","description":"This cluster centers on GO terms for tissue development (heart, skeletal, nervous system) and Rho-mediated signal transduction, with links to calcium-dependent exocytosis and actin/cytoskeleton remodeling. The combination suggests proteins involved in development-related signaling and cytoskeletal regulation, with additional cellular response themes (e.g., nutrient or stress responses) that may reflect broader cellular signaling roles.","confidence":"Medium","size":9,"edges":28,"triangles":43,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007507","count":7},{"id":"GO:0007266","count":7},{"id":"GO:0001501","count":7},{"id":"GO:0045956","count":7},{"id":"GO:0007399","count":7}]},{"hash":"958582973027998982","title":"mRNA Splicing and Translation Initiation Complexes","description":"The cluster shows strong enrichment for mRNA processing and translation initiation functions: spliceosome-mediated splicing and splice-site recognition, mRNA stabilization, regulation of translational initiation, and assembly of the translation preinitiation complex (including eIF4F). This suggests a coordinated role in mRNA maturation and the start of translation, with potential regulation under stress.","confidence":"High","size":9,"edges":34,"triangles":71,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":6},{"id":"GO:0045292","count":6},{"id":"GO:0097010","count":5},{"id":"GO:0010610","count":5},{"id":"GO:0001731","count":5}]},{"hash":"235221123176402608","title":"Neural development and neuron differentiation","description":"The cluster\u2019s top GO terms are strongly centered on neural development, including spinal cord motor neuron fate specification, spinal cord-associated neuron differentiation, and peripheral nervous system neuron axonogenesis. While a few terms touch on broader morphogenesis or other systems (e.g., plant morphogenesis, immune signaling), the recurrent theme is neuronal differentiation and development, suggesting this cluster reflects neural developmental processes.","confidence":"Medium","size":9,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0021520","count":6},{"id":"GO:0035331","count":6},{"id":"GO:0046013","count":6},{"id":"GO:0045856","count":6},{"id":"GO:0071657","count":6}]},{"hash":"1150226546638963943","title":"Proton-driven Ion Transport and Homeostasis","description":"These proteins cluster around membrane ion transport processes: several terms point to proton translocation and vacuolar acidification, plus sodium and potassium ion import/export and homeostasis. This suggests components of proton motive force generation and ion balance across membranes, which fits a coherent functional theme more than other GO terms present.","confidence":"High","size":9,"edges":13,"triangles":7,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007035","count":3},{"id":"GO:0031547","count":3},{"id":"GO:0009651","count":3},{"id":"GO:0051595","count":3},{"id":"GO:0086092","count":3}]},{"hash":"1160162709622231243","title":"Unknown","description":"The top GO terms span several unrelated biological contexts (cardiovascular development and coagulation, neural differentiation, metabolism, and stress responses) with no single dominant process or tissue context that ties all proteins together. Because of this lack of a unifying function, a concise, representative label cannot be assigned with confidence.","confidence":"","size":9,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0050873","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0021707","count":3},{"id":"GO:0042744","count":2},{"id":"GO:0032966","count":2}]},{"hash":"2232351617753955932","title":"Transmembrane solute transport","description":"Most terms describe transmembrane transport of diverse solutes (xenobiotics, vitamins such as ascorbic acid/dehydroascorbic acid, nitrates, potassium, sialic acid, selenite). This common theme indicates a cluster of solute transporters across the plasma membrane. Thus, Transmembrane solute transport.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":5},{"id":"GO:0035461","count":5},{"id":"GO:0055114","count":4},{"id":"GO:0019852","count":4},{"id":"GO:0070715","count":4}]},{"hash":"1637173466239410728","title":"Nuclear import/export and RNA processing","description":"This cluster is driven by terms tied to nuclear transport\u2014NLS-bearing protein import into the nucleus, ribosomal protein import into the nucleus, and mRNA export from the nucleus\u2014as well as RNA processing (tRNA processing). While a few other terms (intraciliary transport, kinetochore localization, synaptic transmission, viral processes) appear in the set, the dominant theme centers on nucleo-cytoplasmic trafficking and RNA metabolism, suggesting these proteins participate in nuclear-cRNA processing pathways.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006607","count":3},{"id":"GO:0006610","count":3},{"id":"GO:0042176","count":3},{"id":"GO:0006406","count":3},{"id":"GO:0016032","count":2}]},{"hash":"1960196405886220008","title":"Embryonic development and morphogenesis","description":"The top GO terms cluster around various organ and tissue development processes (ureteric bud morphogenesis, pancreatic development, left-right patterning, endocrine system development, placenta development, cartilage morphogenesis, trophoblast differentiation, EMT in heart development), indicating a broad developmental/tissue morphogenesis theme rather than a single specific function. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090190","count":3},{"id":"GO:0003323","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0060806","count":2}]},{"hash":"7173081316556096","title":"Iron transport and detoxification","description":"The cluster is enriched for GO terms related to iron metabolism: siderophore-iron import, iron ion transport, and detoxification of iron ions. Together with redox-related terms and stress response, these point to a cohesive function in iron homeostasis and handling of iron-associated oxidative stress. Although some terms are obsolete, the core signals consistently indicate iron transport and detoxification activities.","confidence":"High","size":9,"edges":9,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:1904231","count":2},{"id":"GO:0006950","count":2},{"id":"GO:0006880","count":2},{"id":"GO:0033214","count":2}]},{"hash":"828137809371061277","title":"Inflammation-Associated Angiogenesis Signaling","description":"Dominant GO terms point to inflammatory signaling and angiogenesis (positive regulation of angiogenesis; production of molecular mediators in inflammatory response; chemokine production) with supporting lipid signaling (diacylglycerol and sphingoid metabolism) and non-canonical NF-kappaB pathway regulation. Some metabolism-related and chitin-catabolic terms are less cohesive with the main theme, possibly reflecting annotation noise or broader functional contexts. Overall, the cluster centers on inflammation-driven signaling with angiogenesis and lipid-mediated regulation.","confidence":"Medium","size":9,"edges":11,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":2},{"id":"GO:0006032","count":1},{"id":"GO:0002532","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0090197","count":1}]},{"hash":"1775429442449739439","title":"Glycosylation and ER-Golgi trafficking","description":"This cluster is driven by glycosylation-related processes (protein glycosylation, N-glycan fucosylation, Lewis a epitope biosynthesis, fucose metabolism) and ER-to-Golgi vesicle transport, pointing to a shared role in glycoprotein maturation and trafficking. Some immune and neural terms appear as contextual roles of glycosylation in immune signaling and neuronal development.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":2},{"id":"GO:0006888","count":1},{"id":"GO:0002361","count":1},{"id":"GO:0010493","count":1},{"id":"GO:0002522","count":1}]},{"hash":"1075918446756172287","title":"Leukocyte adhesion and ECM remodeling","description":"The GO terms cluster around immune cell adhesion and tissue remodeling, including leukocyte tethering/rolling and complement signaling, epithelial migration, and extracellular matrix organization. Additional hints of lipid signaling (apolipoprotein A-I\u2013mediated signaling and cholesterol response) may modulate these adhesion/migration processes. Despite no edges, the recurring themes point to leukocyte\u2013ECM interactions during inflammation and remodeling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903238","count":1},{"id":"GO:0002430","count":1},{"id":"GO:0035640","count":1},{"id":"GO:0048745","count":1},{"id":"GO:0038027","count":1}]},{"hash":"2001972779697947809","title":"DNA Repair and Oxidative Stress Response","description":"This cluster links DNA maintenance activities (DNA recombination, replication, base-excision repair) with oxidative-stress defenses (hydrogen peroxide response, redox homeostasis) and xenobiotic response, plus apoptosis, suggesting a genome-stability and stress-response module.","confidence":"High","size":9,"edges":29,"triangles":44,"max_degree":8,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":5},{"id":"GO:0042493","count":5},{"id":"GO:0006260","count":3},{"id":"GO:0071375","count":3},{"id":"GO:0006284","count":3}]},{"hash":"195496546385899232","title":"Unknown","description":"The GO terms span diverse and largely unrelated cellular processes (protein quality control via ERAD, kinase signaling regulation, cell cycle checkpoints, organismal growth, nuclear transport, ribosome biogenesis, cytoskeletal actin nucleation, brain development, lipid signaling, and cell division), with no single cohesive function emerging to define the cluster. Confidence is None.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0061099","count":3},{"id":"GO:1901976","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0031081","count":3}]},{"hash":"1236968097507553763","title":"Developmental and Cytokine-Response Cluster","description":"A mix of terms for developmental processes (chitin-based cuticle development, cartilage and lung development) and immune/cytokine signaling (interleukin-1/6/8 responses, cellular response to IL-1, IL-8 production) plus stress-related and apoptotic processes. No single dominant function emerges, so the label reflects the dual developmental-immune theme without overfitting.","confidence":"Medium","size":9,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":1},{"id":"GO:0040003","count":1},{"id":"GO:0030324","count":1},{"id":"GO:0072606","count":1},{"id":"GO:0009612","count":1}]},{"hash":"215661260842477671","title":"Golgi organization and Golgi-to-ER transport","description":"The dominant GO terms focus on Golgi apparatus structure and vesicle trafficking, especially Golgi organization and retrograde transport from Golgi to the ER, with supporting terms for protein localization to the Golgi and intracellular transport. A few developmental or cytokinesis terms appear but are less represented, indicating the cluster is primarily about Golgi-related trafficking. ","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007030","count":2},{"id":"GO:0006890","count":2},{"id":"GO:0010016","count":1},{"id":"GO:0009933","count":1},{"id":"GO:0000916","count":1}]},{"hash":"143121235268379385","title":"Developmental differentiation and epigenetic regulation","description":"The cluster is dominated by GO terms linked to tissue development, notably skin development and endodermal differentiation, with supporting hits for chromatin remodeling and DNA methylation, pointing to regulation of gene expression during development. The presence of a few transport-related terms appears ancillary and less cohesive with the main theme, suggesting these may reflect multi-functionality or annotation noise rather than a core cluster feature. Overall, a developmental/epigenetic regulatory theme best fits the data.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0045715","count":2},{"id":"GO:0035987","count":2},{"id":"GO:0043044","count":1},{"id":"GO:0010425","count":1}]},{"hash":"701216372902702119","title":"Muscle membrane excitability and T-tubule organization","description":"The terms cluster around muscle cell membrane physiology: proton transport and maintenance of electrochemical gradients point to ion pumps, while T-tubule organization and skeletal muscle relaxation reflect excitation-contraction coupling. Additional items like response to testosterone and glycosides, along with modulation of NO signaling, suggest hormonal and cardiac/muscle signaling influences on membrane function. The overall theme is muscle membrane excitability and associated signaling pathways.","confidence":"Medium","size":8,"edges":19,"triangles":22,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0015991","count":6},{"id":"GO:1901205","count":5},{"id":"GO:1903249","count":5},{"id":"GO:0010248","count":5},{"id":"GO:0016311","count":5}]},{"hash":"1336008060943065253","title":"Splicing and Translation Regulation","description":"The cluster\u2019s GO terms are dominated by RNA processing and protein synthesis control, including spliceosomal tri-snRNP complex assembly, translation, and regulation of translational termination and cytoplasmic translation. While a few stress- or detox-related terms appear, the strongest signals point to RNA splicing and translational regulation as the core theme, suggesting these proteins coordinate RNA maturation with protein synthesis.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042738","count":2},{"id":"GO:0035902","count":2},{"id":"GO:0032094","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0000244","count":1}]},{"hash":"936305371604169719","title":"Cytoskeletal transport and proteostasis under stress","description":"The dominant terms point to microtubule dynamics (GO:0031109), anterograde axonal transport (GO:0099641), and regulation of intracellular transport (GO:0032387), plus protein stabilization (GO:0050821) and stress responses (GO:0042542, GO:0042542; GO:1900034). Lens fiber morphogenesis (GO:0070309) and negative regulation of amyloid fibril formation (GO:1905907) suggest proteostasis in specialized tissues like lens and neurons. Together, they indicate a module coordinating cytoskeleton, trafficking, and protein homeostasis under stress.","confidence":"Medium","size":8,"edges":22,"triangles":27,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1905907","count":3},{"id":"GO:0099641","count":3},{"id":"GO:0070309","count":3},{"id":"GO:0031109","count":3},{"id":"GO:1900034","count":3}]},{"hash":"1527190387982261135","title":"Post-transcriptional RNA processing and translation initiation","description":"This cluster is centered on post-transcriptional regulation, with enriched GO terms related to mRNA stability, processing, splicing, and translation initiation (including eIF4F complex assembly and preinitiation complex formation), indicating a cohesive role in RNA processing and control of translation.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":6},{"id":"GO:0097010","count":5},{"id":"GO:0006378","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0006446","count":5}]},{"hash":"128639677224525985","title":"Collagen-driven ECM remodeling and ossification","description":"The set of GO terms is centered on collagen-related activities (collagen catabolic process; collagen-activated receptor signaling) and skeletal development (intramembranous ossification; cartilage condensation). This suggests extracellular matrix remodeling linked to bone/cartilage formation as the cluster's primary function. A few terms refer to complement activation, which may reflect background association but do not define the main theme here.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":2},{"id":"GO:0030574","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0034381","count":1},{"id":"GO:0033034","count":1}]},{"hash":"1275868886487375083","title":"Histone and rRNA methyltransferases","description":"This cluster is characterized by GO terms centered on methylation activities, including rRNA methylation, peptidyl-lysine dimethylation, peptidyl-arginine dimethylation, peptidyl-glutamine methylation, and rDNA heterochromatin formation. Together these indicate enzymes that transfer methyl groups to RNA or protein substrates, implicating roles in chromatin regulation and ribosomal RNA modification. Some additional terms like cobalamin biosynthesis and stress responses may be linked to broader methylation-dependent pathways, but the dominant signal is methyltransferase activity tied to epigenetic and ribosomal regulation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031167","count":5},{"id":"GO:0018027","count":4},{"id":"GO:0000183","count":3},{"id":"GO:0043985","count":3},{"id":"GO:0019919","count":3}]},{"hash":"1502302744652995655","title":"Innate Immunity and Tissue Remodeling","description":"The top GO terms point to neutrophil- and leukocyte- mediated defense, leukocyte adhesion, and endothelial barrier regulation, combined with elastin catabolic (ECM) remodeling and coagulation factor XII activation, suggesting a cluster centered on innate immune responses intertwined with vascular/endothelial remodeling and ECM turnover during inflammation.","confidence":"Medium","size":8,"edges":22,"triangles":29,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042127","count":5},{"id":"GO:1903238","count":5},{"id":"GO:0060309","count":5},{"id":"GO:0002542","count":5},{"id":"GO:0070947","count":5}]},{"hash":"821814151640324544","title":"Cytoskeleton-driven cell migration and adhesion","description":"This cluster centers on actin cytoskeleton remodeling (lamellipodium assembly, leading edge localization), cell spreading and adhesion processes, and requires coordination of epithelial/endothelial morphogenesis and immune cell signaling. The convergence of lamellipodium/leading-edge terms with adhesion and motility-related processes suggests a cohesive theme of cytoskeleton-dependent cell migration and cell\u2013cell/ECM adhesion across cell types.","confidence":"Medium","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033144","count":4},{"id":"GO:1900026","count":4},{"id":"GO:0031532","count":3},{"id":"GO:0097498","count":3},{"id":"GO:0071593","count":3}]},{"hash":"442857772725005742","title":"Unknown","description":"The GO terms show a highly heterogeneous mix including plant hormone signaling (cytokinin), sugar and secondary metabolite catabolism (cellulose, lactose, glucosinolate), animal signaling pathways (insulin receptor, MAPKKK via FGF), and vascular development terms (endothelial tube lumen extension), plus mitochondrial complex IV assembly. This lack of a cohesive, single-function theme across the cluster makes a specific functional label unreliable.","confidence":"","size":8,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":2},{"id":"GO:0090080","count":2},{"id":"GO:0009736","count":2},{"id":"GO:0030245","count":2},{"id":"GO:0019512","count":2}]},{"hash":"1451919706063383592","title":"Lipid biosynthesis and sphingolipid metabolism","description":"This cluster centers on lipid-related processes: sphinganine and sphingosine biosynthesis, monounsaturated fatty acid biosynthesis, and broader fatty acid responses, suggesting a core theme of lipid metabolism and sphingolipid pathways. Some terms reflect organism- or tissue-specific roles (e.g., adipogenesis and tarsal gland development), but the dominant signal is lipid biosynthesis and lipid signaling.","confidence":"Medium","size":8,"edges":10,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":3},{"id":"GO:0010205","count":2},{"id":"GO:0044130","count":2},{"id":"GO:0033561","count":2},{"id":"GO:0006667","count":2}]},{"hash":"1556246916349498571","title":"Immune cell migration and cytoskeletal remodeling","description":"The top terms center on actin cytoskeleton dynamics (reorganization, lamellipodium, leading edge), lymphocyte clustering and T cell receptor signaling, along with endothelial tube formation and cell adhesion. This suggests a functional theme of immune cell motility and signaling coupled with cytoskeletal remodeling and interactions with endothelium, i.e., migration and tissue remodeling processes.","confidence":"High","size":8,"edges":5,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031532","count":8},{"id":"GO:0097498","count":8},{"id":"GO:0071593","count":8},{"id":"GO:0010592","count":8},{"id":"GO:0035264","count":8}]},{"hash":"1576600509004472210","title":"mRNA processing and translation initiation regulation","description":"The terms cluster around mRNA fate: splicing (spliceosome), mRNA stability, and initiation of translation (eIF4F assembly, preinitiation complex formation, translational initiation regulation). This points to a coherent theme of post-transcriptional control combining splicing regulation with translation initiation.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":6},{"id":"GO:0000381","count":5},{"id":"GO:1901407","count":5},{"id":"GO:0000398","count":4},{"id":"GO:0097010","count":4}]},{"hash":"138804631694961114","title":"Golgi-ER vesicle transport","description":"The top terms cluster around vesicle trafficking involving the Golgi, including ER-to-Golgi transport, intra-Golgi transport, retrograde endosome-to-Golgi movement, and Golgi ribbon formation, indicating a cohesive Golgi- and vesicle-transport functional group. A few terms (cell cycle, mRNA capping) are less connected to this theme but do not overwhelm the dominant Golgi-transport signal.","confidence":"Medium","size":8,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048280","count":3},{"id":"GO:0007049","count":2},{"id":"GO:0042144","count":2},{"id":"GO:0042147","count":2},{"id":"GO:0006891","count":2}]},{"hash":"978160003900284933","title":"ER-Golgi Trafficking and Exosome Secretion","description":"The top GO terms cluster around secretory pathway functions: post-translational targeting to the endoplasmic reticulum membrane, protein retention in the Golgi, and regulation of exosomal secretion, along with ubiquitin-independent proteolysis via the multivesicular body sorting pathway. This points to a coherent role in ER-Golgi trafficking and vesicle-mediated protein export, including exosome biogenesis. The presence of a few mitosis-related terms appears ancillary rather than central to the cluster\u2019s primary function. Overall, the cluster seems best described by vesicle trafficking and exosome formation processes.","confidence":"High","size":8,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097264","count":1},{"id":"GO:1902188","count":1},{"id":"GO:0090611","count":1},{"id":"GO:0030447","count":1},{"id":"GO:0071454","count":1}]},{"hash":"218050734117844158","title":"Carbohydrate and isoprenoid biosynthesis","description":"This cluster shows strong signals for carbohydrate metabolism (carbohydrate phosphorylation, myo-inositol phosphate biosynthesis, glycolytic processing from galactose) and isoprenoid/sterol production (isopentenyl diphosphate biosynthetic pathways, cholesterol biosynthesis). There are also related amino acid biosynthesis terms and galactose-regulated transcription, suggesting a broader metabolic module. The lack of edges indicates proteins may be functionally dispersed but still tied to central metabolism; thus the label captures the main recurring theme.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":3},{"id":"GO:0010264","count":2},{"id":"GO:0019288","count":2},{"id":"GO:0009086","count":2},{"id":"GO:0000435","count":2}]},{"hash":"500422131884711905","title":"GPCR Signaling and Trafficking","description":"The cluster is dominated by GO terms related to G protein-coupled receptor (GPCR) signaling, especially pathways that inhibit adenylate cyclase (Gi/o-coupled) and processes tied to receptor trafficking such as internalization and desensitization by arrestin. Additional terms point to dopamine and adrenergic receptor signaling and a link to photoreceptor GPCR function, suggesting a cohesive theme around GPCR signaling and regulation across neuronal/retinal contexts. Some terms (IL-6 regulation, Wnt secretion, reproductive processes) are broader contextual associations but do not override the core GPCR-focused theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0031635","count":8},{"id":"GO:0002032","count":8},{"id":"GO:0014059","count":8},{"id":"GO:0045494","count":8},{"id":"GO:0071882","count":8}]},{"hash":"2025128189137069176","title":"Unknown","description":"The top GO terms span vascular endothelial proliferation and differentiation, Wnt signaling, neuronal and epithelial differentiation, and ubiquitination, indicating diverse developmental and signaling roles rather than a single cohesive function; with no network edges among proteins, there is no clear unifying process tying these proteins together.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903589","count":3},{"id":"GO:1901594","count":3},{"id":"GO:0060843","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0071446","count":3}]},{"hash":"1709677562642345732","title":"Larval chitin-based cuticle development","description":"All top GO term is larval chitin-based cuticle development, suggesting the proteins are involved in forming or remodeling the larval insect cuticle rich in chitin. The cluster\u2019s connectivity (edges/triangles) supports a cohesive module in this developmental process, with no other dominant functions indicated.","confidence":"High","size":8,"edges":20,"triangles":24,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":6}]},{"hash":"68344902012790743","title":"Neural development and axon guidance","description":"The top GO terms are dominated by nervous system development, brain development, axon guidance, and signaling pathways (ERK and Rho) involved in neuronal differentiation and pathfinding, suggesting a coherent theme of neural development and axon guidance across the cluster. Some immune-related terms appear but are comparatively peripheral to the main neural development signal.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0007411","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0035023","count":4}]},{"hash":"1804963134979513935","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0031120","count":2},{"id":"GO:0001682","count":2},{"id":"GO:0000185","count":2}]},{"hash":"1732485295311995821","title":"Signal transduction and cytoskeletal regulation","description":"The cluster centers on signaling and its regulation: several terms describe modulation of phosphorylation events, ERK/MAPK signaling, and GPCR-associated pathways, along with protein ubiquitination. Stress fiber assembly points to cytoskeletal remodeling, which often accompanies signaling responses. Sensory-related terms (touch perception and photoreceptor maintenance) and insulin secretion signaling broaden the network to include cellular response contexts. Taken together, these proteins appear to function in regulating signaling pathways and associated structural dynamics rather than a single enzymatic activity.","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0033138","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0043149","count":3},{"id":"GO:0050975","count":3},{"id":"GO:0070374","count":3}]},{"hash":"1114263856512516410","title":"GPCR Signaling and Dopamine Regulation","description":"This cluster is dominated by GO terms describing G protein-coupled receptor signaling, including adrenergic, dopamine, and opioid pathways, along with GPCR internalization and arrestin-related desensitization. The terms also touch on dopamine secretion regulation and photoreceptor maintenance, which aligns with GPCR roles in vision and neuromodulation that influence blood pressure and neural signaling. The electron transport chain appears but is less central to the shared theme, which remains GPCR-mediated signaling and neurotransmitter regulation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":5},{"id":"GO:0022900","count":5},{"id":"GO:0010579","count":5},{"id":"GO:0031635","count":4},{"id":"GO:0002032","count":4}]},{"hash":"1584706606015623895","title":"DNA Damage Response and Cell Fate","description":"This cluster centers on DNA damage response and cell fate decisions, with key terms for NHEJ repair, apoptosis, and cell cycle control. Supporting terms on proteostasis and chromatin remodeling align with cellular responses to stress and DNA damage; immune signaling terms may reflect cross-talk between DNA damage responses and inflammation.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0006303","count":8},{"id":"GO:0071347","count":8},{"id":"GO:0030433","count":8},{"id":"GO:1901694","count":8},{"id":"GO:1990920","count":8}]},{"hash":"2212783717817928659","title":"Developmental and Immune Signaling","description":"This cluster includes GO terms for extracellular matrix organization, eye morphogenesis, and various signaling pathways (RTK, Wnt), along with immune-related terms (TLR2 signaling, cytokine signaling, response to fungus) and axonogenesis, suggesting a broad involvement of signaling in development and immune responses, with ECM remodeling as a related facet.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":2},{"id":"GO:0048593","count":2},{"id":"GO:0007169","count":1},{"id":"GO:0034134","count":1},{"id":"GO:0007409","count":1}]},{"hash":"493227520696323374","title":"Glutamatergic synaptic transmission and plasticity","description":"Based on the top GO terms, this cluster centers on neuronal signaling and memory: multiple entries relate to synaptic transmission (glutamatergic), positive regulation of synaptic transmission, and long-term plasticity; other terms point to ion transport (potassium), receptor internalization, and memory-related processes (memory, conditioned taste aversion, lithium response). While a few terms touch development, the dominant functional theme is neuronal communication and plasticity.","confidence":"High","size":8,"edges":13,"triangles":7,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0072375","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0010226","count":5},{"id":"GO:0001661","count":5},{"id":"GO:0050806","count":5}]},{"hash":"998770696099112747","title":"Cross-tissue developmental gene regulation","description":"The cluster\u2019s terms center on development and tissue differentiation across multiple organ systems (axis specification, cardiac morphogenesis, cerebellar neuron differentiation, floral organ development) and general transcriptional regulation, suggesting a shared theme of gene regulation during development. Immune-related terms are present but less prominent, making the core signal developmental regulation rather than a single pathway. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046826","count":2},{"id":"GO:0007352","count":2},{"id":"GO:0003220","count":2},{"id":"GO:0021707","count":2},{"id":"GO:0006351","count":2}]},{"hash":"2183870868767016640","title":"mRNA processing and translation initiation","description":"Proteins are linked to mRNA processing and translation initiation. Key terms include eIF4F complex assembly, preinitiation complex formation, initiation regulation, and mRNA stabilization/splicing, indicating a shared role in preparing transcripts for translation and managing stability under stress. Some obsolete terms are included, but the core theme remains translational control and RNA maturation.","confidence":"High","size":7,"edges":17,"triangles":19,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0097010","count":3},{"id":"GO:0010610","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0006446","count":3}]},{"hash":"91802761459748442","title":"GPCR signaling with ERK and cAMP downstream","description":"This cluster centers on G protein-coupled receptor signaling with downstream phosphorylation events, including ERK cascade activation, cAMP signaling, and dopamine receptor signaling (and related responses such as morphine sensitivity). The presence of GPCR internalization, dopamine pathways, and ERK/cAMP modulation supports a neural signaling module, with some peripheral terms possibly reflecting pleiotropic roles. ","confidence":"Medium","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0002031","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0007191","count":2}]},{"hash":"1455129214836154305","title":"Lipid biosynthesis and mitochondrial function","description":"The proteins show enrichment for lipid-related processes (unsaturated fatty acid biosynthesis, ergosterol biosynthesis regulation, phosphatidylinositol dephosphorylation) and mitochondrial activities (mitochondrial electron transport NADH to ubiquinone, inheritance). Terms like central nervous system myelin maintenance and sebaceous gland differentiation reflect lipid-rich membrane biology, supporting a theme around lipid metabolism and membrane maintenance, with mitochondrial energy production as a core component. Some terms (nitrate assimilation, NO biosynthesis) are ancillary but do not contradict the main theme.","confidence":"Medium","size":7,"edges":9,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032286","count":2},{"id":"GO:0006675","count":2},{"id":"GO:0001949","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0032443","count":2}]},{"hash":"1010791373410019466","title":"Nuclear regulation and ribosome turnover","description":"This cluster shows enrichment for chromatin-related regulation (negative regulation of histone deacetylation, regulation of rRNA processing, regulation of protein localization to the nucleus) and ribosome turnover (ribophagy, regulation of protein catabolic process), with some links to broader signaling pathways (ERK and Hippo) and protein localization. The common theme is regulation of nuclear/chromatin dynamics and proteostasis, including ribosome turnover, rather than a single specific pathway.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031064","count":3},{"id":"GO:0002669","count":3},{"id":"GO:0070373","count":2},{"id":"GO:2000232","count":2},{"id":"GO:1900180","count":2}]},{"hash":"1828578365082802110","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":7,"triangles":1,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0042273","count":5},{"id":"GO:0000466","count":5},{"id":"GO:0000462","count":5},{"id":"GO:0000398","count":5},{"id":"GO:0000472","count":5}]},{"hash":"2140850052843366693","title":"Innate immune gene expression regulation","description":"The proteins in this cluster connect innate immune signaling (innate immune response, LPS response, antiviral genome regulation) with broad regulation of gene expression, including mRNA processing, alternative splicing, translation initiation control via eIF2\u03b1 phosphorylation, transcription, and CpG methylation\u2013mediated regulation. This suggests a cohesive program that links immune sensing to transcriptional and post-transcriptional control of immune-related genes.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":2},{"id":"GO:0010998","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0009636","count":2}]},{"hash":"728034363685261540","title":"mRNA processing and translation initiation regulation","description":"The top terms point to post-transcriptional gene expression control, including mRNA splicing and spliceosome activity, mRNA stabilization, translation initiation complex formation, and regulation of translational initiation. This suggests the proteins act together in mRNA maturation and the control of when and how efficiently mRNA is translated, rather than transcriptional processes. Some terms are obsolete but reinforce the same themes.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":7},{"id":"GO:0097010","count":6},{"id":"GO:0010610","count":6},{"id":"GO:0001731","count":6},{"id":"GO:0006446","count":6}]},{"hash":"963651108904991332","title":"Lens Development and Visual Perception","description":"The top GO terms are dominated by eye-related processes, notably lens development in camera-type eye and visual perception, with supporting signals like vitamin A\u2013related responses. A few terms (oxidative stress, unrelated developmental processes) may be noise, but the eye/vision theme is the strongest signal. ","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0002088","count":2},{"id":"GO:0007601","count":2}]},{"hash":"1866922905340964139","title":"Developmental Signaling and Morphogenesis","description":"This cluster centers on signaling pathways that drive tissue morphogenesis across nervous system, inner ear, and kidney (nervous system development, vestibular receptor morphogenesis, slit diaphragm assembly, kidney development, ROBO signaling, SHH/SMO), with some immune signaling terms present but not defining the group.","confidence":"Medium","size":7,"edges":18,"triangles":23,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":5},{"id":"GO:0036060","count":4},{"id":"GO:0034164","count":4},{"id":"GO:0048671","count":4},{"id":"GO:0035385","count":4}]},{"hash":"720272108622403507","title":"Oxidative metabolism and catabolic pathways","description":"The GO terms are dominated by oxidation-reduction and catabolic processes (fatty acid omega-oxidation, formaldehyde catabolism, non-phosphorylated glucose catabolism) with mentions of NADH oxidation, suggesting a cluster of proteins involved in oxidative metabolism and energy-yielding catabolism. A couple terms (copper ion response, extracellular signal regulation) seem less central, likely representing ancillary or context-specific roles or annotation noise.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":1,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0010430","count":3},{"id":"GO:0000947","count":3},{"id":"GO:0046294","count":3},{"id":"GO:0046688","count":3}]},{"hash":"2181499852385312421","title":"Transmembrane Transporters","description":"This cluster is strongly characterized by GO terms for transmembrane transport across various substrates (chloride, sulfate, oxalate, L-aspartate, fructose) and regulation of membrane potential and pH, pointing to a core function as membrane transport proteins and ion/solute carriers. Some terms related to capacitation and sensory perception of sound likely reflect ion-channel roles in specialized tissues, which still align with transporter/ion-transport themes.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042391","count":5},{"id":"GO:0048240","count":5},{"id":"GO:0007605","count":5},{"id":"GO:1902358","count":5},{"id":"GO:0019532","count":5}]},{"hash":"135798086308914942","title":"Angiogenesis and Endothelial Cell Migration","description":"This cluster is dominated by GO terms for angiogenesis and endothelial cell migration, suggesting a vascular development signature. Other terms (axonogenesis, T cell receptor signaling, GPCR desensitization, apoptosis) indicate broader signaling roles, but the strongest and most recurrent signals point to angiogenic processes.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0043536","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0031532","count":3},{"id":"GO:0007409","count":3},{"id":"GO:0010898","count":3}]},{"hash":"2073451696075014395","title":"Unknown","description":"The top GO terms span innate immunity (neutrophil-mediated killing of fungus, leukocyte tethering), coagulation (Factor XII activation), extracellular matrix remodeling (elastin catabolic process), digestion, and developmental signaling (Wnt pathway, multicellular growth); there is no single cohesive function that unifies these terms across the seven proteins, so a precise, representative label cannot be confidently assigned.","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0042127","count":2},{"id":"GO:1903238","count":2},{"id":"GO:0060309","count":2},{"id":"GO:0002542","count":2}]},{"hash":"594804472422283400","title":"Bacterial cell wall biosynthesis","description":"The dominant GO terms point to direct involvement in bacterial cell wall construction and remodeling, including peptidoglycan biosynthesis, lipoteichoic acid biosynthesis, and cell wall organization, with additional support from cell division. While a few terms (plant flavonoid biosynthesis, estrogen catabolic process, paranode localization) seem mismatched and may reflect annotation noise or multifunctional enzymes, the core signal among the top terms centers on bacterial envelope biosynthesis and related growth processes.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009252","count":6},{"id":"GO:0033330","count":6},{"id":"GO:0033303","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0071555","count":6}]},{"hash":"1973283998382095864","title":"Neuronal ion and metabolite transport","description":"This cluster shows multiple transmembrane transport terms for ions (sodium, potassium) and small metabolites (glucose, pantothenate, myo-inositol, biotin), pointing to membrane transporter functions. The inclusion of acetylcholine biosynthetic process and neural activity terms (memory, rhythmic excitation) suggests a neuronal context, implying the proteins are involved in ion and metabolite transport linked to neurotransmission. Overall, the common theme is transporters operating in neurons.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071436","count":1},{"id":"GO:1904659","count":1},{"id":"GO:0015887","count":1},{"id":"GO:0015798","count":1},{"id":"GO:0015878","count":1}]},{"hash":"480646941610174678","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0097428","count":1},{"id":"GO:0036494","count":1},{"id":"GO:0034975","count":1},{"id":"GO:0030433","count":1}]},{"hash":"2151381019038747385","title":"ER Stress and Protein Folding","description":"These proteins cluster around ER quality control: unfolded protein response, ER protein folding, and translation upregulation in response to ER stress, with redox homeostasis supporting ER function. Some retina-related terms appear as outliers, but the dominant theme is ER stress\u2013driven protein folding.","confidence":"High","size":7,"edges":7,"triangles":0,"max_degree":4,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0036494","count":5},{"id":"GO:0070389","count":5},{"id":"GO:0006986","count":5},{"id":"GO:0034975","count":3},{"id":"GO:0030433","count":3}]},{"hash":"1455998894440803974","title":"Embryonic neural and pancreatic development","description":"These terms cluster around embryogenesis with emphasis on neural development (midbrain, dorsal spinal cord, neural crest migration, facial nucleus, roof of mouth) and pancreatic development (endocrine pancreas development, type B pancreatic cell differentiation), plus embryonic digestive tract morphogenesis. The shared theme is broad embryonic development across neural and pancreatic lineages, making this label both specific and representative of the cluster\u2019s functions.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0030901","count":4},{"id":"GO:0031018","count":4},{"id":"GO:0090190","count":3},{"id":"GO:0048557","count":3}]},{"hash":"634913698160354026","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":4},{"id":"GO:0042787","count":3},{"id":"GO:0045116","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0031146","count":2}]},{"hash":"1037903267241139763","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0097171","count":3},{"id":"GO:0009718","count":3},{"id":"GO:0009244","count":3},{"id":"GO:0080110","count":3}]},{"hash":"931996671677211602","title":"Ubiquitin-regulated innate immune signaling and cell death","description":"Most represented GO terms point to ubiquitination events (autoubiquitination, polyubiquitination; K6- and K48-linked), together with innate immune signaling (TLR regulation, NF-\u03baB/I\u03baB phosphorylation) and JNK pathway control, and necroptosis regulation. This indicates a coherent cluster of ubiquitin-dependent modulation of immune signaling and inflammatory cell death, with spermatid development appearing as peripheral noise.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0034121","count":2},{"id":"GO:0046328","count":2}]},{"hash":"1826536079545555181","title":"Neuro-sensory signaling and steroid biosynthesis","description":"The top GO terms point to neural/sensory processes (cerebellar granule cell differentiation, startle response, response to capsazepine) alongside steroid hormone biosynthesis (aldosterone and cortisol) and related responses (vitamin D). There are also xenobiotic/metabolic terms and a few immune-related terms, suggesting a cluster that centers on neural signaling with hormonal and stress-related metabolic outputs rather than a single precise function. Therefore, a label that captures both neural signaling and steroid biosynthesis is appropriate.","confidence":"Medium","size":7,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":2},{"id":"GO:0001964","count":2},{"id":"GO:0032342","count":2},{"id":"GO:0034651","count":2},{"id":"GO:0033280","count":2}]},{"hash":"1266395751818903924","title":"Synaptic vesicle trafficking and secretion","description":"These proteins show a coherent theme of vesicle transport and regulated secretion, including Golgi/endosome trafficking, intra-Golgi transport, endocytic recycling, and modulation of neurotransmitter release. The GO terms point to secretory vesicle management and trafficking to the plasma membrane, with specific references to norepinephrine secretion and vesicle recycling, supporting a unified role in vesicle-based secretion processes.","confidence":"High","size":7,"edges":8,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0010701","count":1},{"id":"GO:0048193","count":1},{"id":"GO:0032456","count":1},{"id":"GO:0042147","count":1},{"id":"GO:0061669","count":1}]},{"hash":"1599599381223407826","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051083","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0000413","count":1}]},{"hash":"1207400907933372534","title":"Neuronal differentiation and synaptic regulation","description":"This cluster is anchored by neuron differentiation and synaptic vesicle clustering terms, with supporting signals in ERK pathway regulation and ubiquitin-dependent degradation via the multivesicular body. These suggest a shared role in neuronal development and synaptic function, while a few terms reference broader processes (embryonic development, immune regulation) that are less directly connected. Overall, the dominant theme reflects neuronal development and synaptic regulation.","confidence":"Medium","size":7,"edges":5,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030182","count":5},{"id":"GO:0043162","count":4},{"id":"GO:0031064","count":4},{"id":"GO:0002669","count":4},{"id":"GO:0001701","count":3}]},{"hash":"2276377499862397730","title":"Adaptive T Cell Signaling and Regulation","description":"This cluster centers on adaptive immune functions (adaptive immune response, T cell homeostasis, T cell proliferation) and regulation of multiple signaling pathways involved in immune activation (TLR signaling, JNK cascade, NF-kappaB, IL-17 signaling) as well as virus defense and protein ubiquitination, suggesting a cohesive role in T cell\u2013driven immune regulation and innate signaling modulation. A single outlier term on obsolete glycosylation does not diminish the overall immune-focused pattern.","confidence":"High","size":7,"edges":17,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":2},{"id":"GO:1901224","count":1},{"id":"GO:0043029","count":1},{"id":"GO:0002250","count":1},{"id":"GO:0051865","count":1}]},{"hash":"1430288719322625172","title":"Oxidative Stress Response","description":"The set shows enrichment for GO terms related to redox balance and response to oxidative stress (cell redox homeostasis; cellular response to oxidative stress). Although some terms are obsolete or broad, the prominent redox/oxidative stress terms suggest a function tied to managing oxidative stress, with other terms possibly reflecting ancillary processes or annotation noise.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0051573","count":2},{"id":"GO:0043046","count":2},{"id":"GO:0006351","count":2}]},{"hash":"2199798308018296398","title":"Neural and craniofacial development","description":"The cluster\u2019s top GO terms cluster around nervous system development and craniofacial morphogenesis (inner ear development, facial nucleus development, midbrain-hindbrain boundary development, spinal motor neuron fate specification, pallidal development, roof of the mouth). Locomotory behavior aligns with neural/motor function, suggesting a coordinated CNS/craniofacial development role. A general note about protein homooligomerization may reflect common regulatory protein interactions in these processes, supporting a cohesive developmental theme.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048839","count":4},{"id":"GO:0021759","count":3},{"id":"GO:0007626","count":3},{"id":"GO:0007338","count":3},{"id":"GO:0007275","count":3}]},{"hash":"2016632085490397432","title":"Cardiac and skeletal muscle development","description":"The top GO terms include heart development and skeletal muscle tissue development, with heart rudiment formation and related cardiac hypertrophy regulation, indicating a core theme of cardiac and muscle tissue formation. Some terms also touch bone ossification and GPCR signaling, suggesting broader developmental signaling, but the dominant signal is cardiomyocyte/muscle development.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0070602","count":1},{"id":"GO:0071877","count":1}]},{"hash":"942914312142510545","title":"Immune cytokine production regulation","description":"The top GO terms are dominated by immune-related cytokine production and regulation across multiple cell types (dendritic cells, mast cells, monocytes) and regulation of inflammatory mediators (e.g., IL-1). While a few terms are obsolete or tangential (e.g., mechanosensation), the recurring theme is modulation of cytokine output and immune signaling, suggesting this cluster centers on immune communication and inflammatory regulation.","confidence":"Medium","size":6,"edges":9,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002859","count":1},{"id":"GO:1904597","count":1},{"id":"GO:0032516","count":1},{"id":"GO:0000187","count":1},{"id":"GO:0010693","count":1}]},{"hash":"54955596400314598","title":"Ribosome biogenesis and translation regulation","description":"The top GO terms are dominated by ribosome-related processes: cytosolic ribosome assembly and ribosome biogenesis, with a note on regulation of translation, suggesting the cluster centers on components and control of protein synthesis. A few other terms (developmental and neuronal) are present but likely represent annotation noise or secondary associations, while the core theme remains ribosome assembly and translation control.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042256","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0006417","count":1},{"id":"GO:0048539","count":1},{"id":"GO:0030595","count":1}]},{"hash":"988717881295741828","title":"Deubiquitinases in apoptosis regulation","description":"The three GO terms point to a cohesive theme where deubiquitination modulates transcription factor DNA-binding activity and the apoptotic pathway. This suggests a cluster of deubiquitinases influencing gene regulation and cell survival, despite limited term support. ","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":1},{"id":"GO:0043392","count":1},{"id":"GO:0042981","count":1}]},{"hash":"969227578240662920","title":"ER Stress and Protein Folding Response","description":"The GO terms cluster around proteostasis: unfolded protein response, chaperone-assisted refolding, SRP-dependent protein targeting to membranes, and ER stress-related processes, suggesting a cohesive module of protein quality control and ER function. Some terms like DNA replication or karyogamy appear less central and may reflect annotation noise.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:1903751","count":6},{"id":"GO:1902037","count":6},{"id":"GO:0070389","count":6},{"id":"GO:0034620","count":6}]},{"hash":"1595258216904012491","title":"Cardiac fatty acid metabolism and development","description":"The GO terms show a strong emphasis on fatty acid metabolism and carnitine-related processes (carnitine metabolic and biosynthetic, fatty-acyl-CoA biosynthesis, beta-oxidation via acetyl-CoA dehydrogenase/oxidase), alongside cardiac development terms (cardiac muscle cell differentiation, heart development) and development-related terms like post-embryonic development. This suggests a cohesive theme where fatty acid oxidation and carnitine-dependent metabolism support cardiac formation and function, with some related metabolic processes also present. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019254","count":3},{"id":"GO:0046949","count":3},{"id":"GO:0033540","count":3},{"id":"GO:0055007","count":3},{"id":"GO:1904070","count":3}]},{"hash":"996661096725909546","title":"Inflammatory Response and Mechanical Stress","description":"The top GO terms point to inflammation-related processes (production of mediators, IL-8 production, response to LPS) and responses to mechanical stimuli, with additional general metabolism terms that are relatively broad. The lack of edges among proteins suggests heterogeneity, so the label emphasizes the strongest shared theme\u2014immune/stress signaling\u2014with a note that other functions appear mixed. Confidence: Low","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0030324","count":3},{"id":"GO:0005975","count":3},{"id":"GO:0032496","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0017000","count":2}]},{"hash":"2182450475248065265","title":"Embryonic organ morphogenesis (kidney and cartilage)","description":"The top GO terms point to organ development processes, especially mesonephric duct development and metanephric distal tubule morphogenesis (kidney-related), along with cartilage condensation. While other terms touch on immune or adhesion processes, the strongest signals are embryonic morphogenesis in kidney and cartilage, justifying a label centered on embryonic organ development. ","confidence":"Medium","size":6,"edges":10,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":2},{"id":"GO:0060355","count":2},{"id":"GO:0006910","count":2},{"id":"GO:0072177","count":2},{"id":"GO:0072287","count":2}]},{"hash":"375394326539639074","title":"Neuronal cytoskeleton and axonal transport","description":"The strongest signals are neuronal: neurofilament cytoskeleton organization and retrograde axonal transport, along with sensory perception of sound and regulation of neuron apoptosis. While there are some immune-related terms and RNA silencing terms present, they are less central to the cluster. Thus the proteins most likely participate in neuronal maintenance and transport, with ancillary regulatory roles.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035195","count":3},{"id":"GO:0048538","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0043524","count":2},{"id":"GO:0007605","count":2}]},{"hash":"9679453849566832","title":"Embryonic development and morphogenesis","description":"This cluster centers on embryonic development and tissue morphogenesis, with terms spanning placental and endocrine differentiation, heart/endocardial cushion EMT, cartilage formation, and endothelial tube morphogenesis, all reflecting early tissue patterning and organ morphogenesis.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":1},{"id":"GO:0060972","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0060806","count":1},{"id":"GO:0060536","count":1}]},{"hash":"475473497758478735","title":"Translational Initiation Regulation and Stress Signaling","description":"The cluster shows recurrent terms related to cytoplasmic translational initiation and its regulation (GO:0002183, GO:0006446), suggesting a core theme of translational control. It also includes several stress- and signaling-related responses (amino acid starvation, nitric oxide, ethylene stimulus) that commonly intersect with translational regulation, with a peripheral connection to DNA replication and GTPase activity. Some terms (like oligodendrocyte development) may reflect broader multifunctionality or annotation overlap, but the dominant signal points to translation initiation control integrated with stress signaling.","confidence":"Medium","size":6,"edges":12,"triangles":9,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0002183","count":2},{"id":"GO:0014003","count":2},{"id":"GO:1903833","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1694368189230320184","title":"Neural development and calcium signaling","description":"The prominent terms center on neural development and calcium signaling\u2014sensory neuron axon fasciculation, AMPA receptor clustering, and store-operated calcium channel/entry\u2014suggesting roles in neural connectivity and calcium-dependent signaling. Other terms reflect broader developmental processes (epithelial differentiation, tubulogenesis, cuticle development), but the neural/calcium theme is most representative of this cluster.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":2},{"id":"GO:0008363","count":1},{"id":"GO:0097498","count":1},{"id":"GO:0030859","count":1},{"id":"GO:0060157","count":1}]},{"hash":"2212122262251085806","title":"Ion Homeostasis and Calcium Signaling","description":"The cluster centers on membrane potential regulation, ion transport (sodium and potassium), and regulation of calcium-release channels, suggesting a shared role in ion homeostasis and calcium signaling at the membrane. Some members touch on signaling and transcription, but the dominant theme is membrane-associated ion regulation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060315","count":2},{"id":"GO:0042391","count":1},{"id":"GO:2000480","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0009454","count":1}]},{"hash":"1766601585331321698","title":"Cell cycle regulation during development","description":"The cluster\u2019s top GO terms emphasize mitotic transitions (G1/S, G2/M, metaphase/anaphase), indicating a core role in cell cycle control. Additional terms point to developmental contexts (embryonic cleavage, cotyledon development) and signaling-related processes (endocytosis, photomorphogenesis regulation), suggesting these proteins coordinate division with growth and development. Overall, the pattern best supports a label centered on cell-cycle regulation within developmental settings.","confidence":"Medium","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000082","count":2},{"id":"GO:0006897","count":2},{"id":"GO:0044346","count":1},{"id":"GO:0010100","count":1},{"id":"GO:0048825","count":1}]},{"hash":"1596365852329570466","title":"Ubiquitin-Mediated Mitotic Regulation","description":"The cluster is dominated by GO terms tied to cell division and mitosis (mitotic cell cycle, anaphase-promoting complex\u2013dependent proteolysis) and ubiquitination (K11-linked). These point to a module of ubiquitin-driven control of mitotic progression, including degradation of cell-cycle regulators, with possible links to chromatin remodeling via histone methylation regulation. While other terms touch on stress and growth, the core theme connects ubiquitin signaling with mitotic regulation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0070979","count":5},{"id":"GO:2001162","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0071276","count":5}]},{"hash":"963873168549211167","title":"Neuronal development and signaling","description":"This cluster is dominated by terms related to nervous system development and axon/neuronal signaling, including nervous system development, Roundabout (ROBO) signaling, Smoothened (Hedgehog) signaling, T cell receptor signaling but in a neural context, and protein localization to the juxtaparanode region of axons, as well as potassium channel clustering. These collectively point to neural development and associated signaling pathways as the core theme, with some immune signaling terms appearing less central. ","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0001822","count":4}]},{"hash":"1811953032847325132","title":"Vesicle trafficking and Fe-S cluster biogenesis","description":"This cluster\u2019s top GO terms center on ER-to-Golgi and intra-Golgi vesicle transport, with positive regulation of GTPase activity, pointing to vesicle trafficking machinery. It also includes 2Fe-2S cluster assembly and iron-sulfur transfer terms, indicating involvement in Fe-S cluster biogenesis and maturation of iron-sulfur\u2013dependent proteins. The combination suggests proteins that participate in both membrane trafficking and Fe-S\u2013related maturation, though several terms are obsolete.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1903232","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0051220","count":1},{"id":"GO:0034396","count":1}]},{"hash":"2259980262706619403","title":"Bacterial cell wall biosynthesis and antibiotic metabolism","description":"The top GO terms are dominated by biosynthetic processes tied to bacterial cell walls (peptidoglycan, lipoteichoic acid, and cell wall organization) and antibiotic biosynthesis/metabolism, suggesting the proteins function in cell-wall assembly and antibiotic-related pathways. Some plant metabolite terms appear but likely incidental; the core theme is bacterial envelope biosynthesis and antibiotic metabolism.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0017000","count":6},{"id":"GO:0009718","count":6},{"id":"GO:0009252","count":5},{"id":"GO:0033330","count":5},{"id":"GO:0033303","count":5}]},{"hash":"463151171975106989","title":"Plasma membrane transporters for ions and metabolites","description":"The top GO terms are dominated by various transmembrane transport processes across the plasma membrane for diverse substrates (nitrate, potassium, organic cations/anions, sialic acid, dehydroascorbic acid, phosphate, selenite), along with related metabolic processes. This pattern suggests a cluster of proteins functioning as plasma membrane transporters handling a range of small molecules and ions.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019852","count":2},{"id":"GO:0070715","count":2},{"id":"GO:0070837","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0071805","count":2}]},{"hash":"1228118440133657735","title":"RNA processing and mRNA metabolism","description":"The majority of top terms are tied to RNA maturation and processing\u2014rRNA maturation, tRNA processing, mRNA splicing and spliceosome assembly, and P-body assembly, along with histone mRNA metabolism. While a couple of terms touch on chromatin or stress responses, the central theme across the cluster is RNA processing and mRNA metabolism.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0009414","count":6},{"id":"GO:0008334","count":6},{"id":"GO:0030490","count":6},{"id":"GO:0070317","count":6},{"id":"GO:0045292","count":6}]},{"hash":"494303931362316020","title":"Ubiquitin-Proteasome Regulation of Cell Cycle","description":"Top GO terms cluster around ubiquitin-dependent protein degradation (SCF, K11-linked, and general ubiquitin pathways) and cell cycle control (metaphase/anaphase transitions, APC-dependent processes, and neddylation). This suggests proteins in this cluster function to regulate mitosis by tagging regulators for degradation, with some links to DNA repair; the viral process term may be incidental. ","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":6},{"id":"GO:0070979","count":5},{"id":"GO:0016032","count":5},{"id":"GO:0042787","count":5},{"id":"GO:0070911","count":5}]},{"hash":"218578969386458813","title":"Vertebrate cranial skeleton and inner ear development","description":"Two of the top GO terms strongly point to cranial skeletal morphogenesis and inner ear development, with additional broad developmental terms supporting a vertebrate developmental theme. While there are immune and signaling-related terms in the list, the dominant signals are embryonic craniofacial and inner ear formation, suggesting the cluster centers on vertebrate development of these structures.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":4},{"id":"GO:0048839","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0071639","count":4}]},{"hash":"1438408462198067761","title":"Cardiac development and heart function regulators","description":"This cluster\u2019s top GO terms strongly point to cardiac biology, including heart development (GO:0007507), heart rudiment formation (GO:0003315), negative regulation of cardiac muscle hypertrophy (GO:0010614), and negative regulation of the force of heart contraction by chemical signal (GO:0003108), as well as related signaling (tachykinin receptor signaling, GO:0007217) and GPCR internalization (GO:0002031). While a few terms touch on cell division (spindle organization) or ossification, the core theme appears to be proteins involved in heart development and regulation of cardiac signaling and function. Overall, a cardio-centric interpretation best fits, with some ambiguity due to non-heart-specific terms.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070602","count":1},{"id":"GO:0071877","count":1},{"id":"GO:0010614","count":1},{"id":"GO:0001957","count":1},{"id":"GO:0002031","count":1}]},{"hash":"1305081813359424962","title":"Cardiac Morphogenesis and Muscle Differentiation","description":"This cluster is dominated by heart development terms (embryonic heart tube formation; endocardial cushion to mesenchymal transition in heart valve formation) and skeletal muscle differentiation, with integrin-mediated adhesion tying these processes together. Though a couple terms are less related (circadian regulation, stomatal development), the core theme points to cardiovascular morphogenesis and muscle lineage specification.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071285","count":6},{"id":"GO:0071400","count":6},{"id":"GO:0033627","count":6},{"id":"GO:0003144","count":6},{"id":"GO:0021520","count":6}]},{"hash":"1158551575728597870","title":"Cardiac development and muscle differentiation","description":"The terms point strongly to heart formation processes (embryonic heart tube formation, endocardial cushion to mesenchymal transition in valve formation, outflow tract morphogenesis) and muscle development (skeletal muscle differentiation, integrin-mediated adhesion). Additional signals of transcriptional regulation and circadian gene expression accompany these developmental roles, supporting a cohesive theme around heart morphogenesis and associated muscle differentiation.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":6},{"id":"GO:0071285","count":4},{"id":"GO:0071400","count":4},{"id":"GO:0033627","count":4},{"id":"GO:0003144","count":4}]},{"hash":"536048532913642519","title":"DNA Damage Response and Chromatin Regulation","description":"The cluster centers on genome maintenance, with multiple terms for DNA damage checkpoints (mitotic intra-S and mitotic G1), nucleotide-excision repair, DNA damage tolerance, and meiotic recombination checkpoint signaling, plus chromatin-related processes like subtelomeric heterochromatin formation and histone H3-K79 methylation. A noisy term is \u201cresponse to cocaine,\u201d which does not fit the core theme. Overall, the proteins appear linked to DNA repair and chromatin regulation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031573","count":3},{"id":"GO:0042220","count":2},{"id":"GO:0070911","count":2},{"id":"GO:0006301","count":2},{"id":"GO:0051598","count":2}]},{"hash":"1508263202359277222","title":"Ubiquitin-proteasome driven cell cycle regulation","description":"This cluster is dominated by GO terms for ubiquitin tagging and proteasomal degradation (K11-linked ubiquitination, SCF-dependent proteolysis) and key cell cycle events (mitotic cycle, G2/M transition), suggesting tight regulation of protein turnover during division. Related terms on DNA repair and development further support a broader role for ubiquitin signaling in growth and genome maintenance.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070979","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0031146","count":6},{"id":"GO:0000086","count":6},{"id":"GO:0001701","count":6}]},{"hash":"886557571086937708","title":"Actin Dynamics and Cell Polarity","description":"The cluster centers on actin cytoskeleton remodeling (lamellipodium/actin cortical patch assembly), and regulation of cell adhesion and cell polarity (including polarity establishment and morphology). While a couple of terms touch on stress or immune signaling, the dominant themes are actin-driven shape changes and adhesion/polarity during developmental processes like wing hair orientation and gastrulation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001737","count":2},{"id":"GO:0071347","count":2},{"id":"GO:0043538","count":2},{"id":"GO:0010592","count":2},{"id":"GO:0070586","count":2}]},{"hash":"2236145325462173229","title":"Immune cell signaling and actin remodeling","description":"This cluster centers on adaptive immune functions (adaptive immune response, B-1 B cell homeostasis) alongside strong links to actin cytoskeleton dynamics (microspike assembly, actin cytoskeleton reorganization) and signal transduction (small GTPase signaling, collagen-activated tyrosine kinase pathways). The combination suggests coordinated immune signaling with cytoskeletal remodeling, as seen in immune cell activation and synapse formation, supported by related receptor and calcium signaling terms. High","confidence":"","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0030035","count":3},{"id":"GO:0070373","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0001922","count":3}]},{"hash":"672365616101228686","title":"Unknown","description":"The GO terms are spread across muscle development, adaptive immune signaling, neural development, metabolism, and apoptosis, with no single dominant function. The cluster has only one edge and no triangles, suggesting weak or incidental associations rather than a cohesive pathway. Because no unifying theme emerges from the top terms, I label this cluster Unknown.","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007519","count":6},{"id":"GO:0050853","count":6},{"id":"GO:0031532","count":5},{"id":"GO:0007409","count":5},{"id":"GO:0010898","count":5}]},{"hash":"55100691030693312","title":"Ubiquitin-Dependent Proteostasis and Immune Regulation","description":"The top GO terms are dominated by ubiquitination and ubiquitin-mediated degradation (protein ubiquitination, autoubiquitination, K48-linked ubiquitination, ubiquitin-dependent proteolysis, ERAD) with additional hints toward histone turnover. Adaptive immune response and negative regulation of RIG-I signaling suggest roles in immune signaling modulation via ubiquitin pathways. Together, this points to a ubiquitin-centric proteostasis/immune regulation cluster.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0039536","count":4},{"id":"GO:0051865","count":3},{"id":"GO:0042787","count":3}]},{"hash":"280519836748918417","title":"Endothelial angiogenesis and Wnt signaling","description":"The cluster centers on endothelial proliferation/differentiation and sprouting angiogenesis, with Wnt signaling explicitly represented, suggesting a vascular development module. Related terms like cerebellar differentiation and ubiquitination appear secondary and do not negate the dominant vascular theme.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1903589","count":3},{"id":"GO:1901594","count":3},{"id":"GO:0060843","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0071446","count":3}]},{"hash":"1025061532782918177","title":"Lipid and Sterol Biosynthesis","description":"The GO terms clustered here are dominated by biosynthetic pathways for lipids, sterols, and related biopolymers (long-chain fatty-acyl-CoA metabolism, sterol biosynthesis, poly-hydroxybutyrate, lipopolysaccharide core, sporopollenin). This suggests a cohesive theme around lipid-based and associated polymer biosynthesis across diverse organisms, with some related sugar-derived pathways. Overall, a lipid/sterol biosynthesis focus best captures the cluster.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0042619","count":6},{"id":"GO:0035336","count":4},{"id":"GO:0097171","count":4},{"id":"GO:0019878","count":4}]},{"hash":"235183780475175767","title":"Auditory and vestibular neural signaling","description":"The cluster is dominated by GO terms related to hearing and balance (inner ear receptor cell development, sensory perception of sound, righting reflex) and neural signaling processes (membrane depolarization, potassium ion transport, negative regulation of nerve impulse transmission), suggesting a cohesive theme of auditory/vestibular neural function. Some terms like response to amyloid-beta or chondrocyte morphogenesis appear as outliers but do not override the central sensory-neural pattern.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060013","count":5},{"id":"GO:0051899","count":5},{"id":"GO:0060119","count":5},{"id":"GO:0043200","count":5},{"id":"GO:0007605","count":5}]},{"hash":"1715121354084689435","title":"Purine Nucleotide Metabolism and DNA Replication Initiation","description":"This cluster is dominated by GO terms related to nucleotide metabolism (ADP/AMP biosynthesis, GTP metabolism, purine interconversion, AMP salvage) and includes a term for DNA replication initiation, implying roles in providing nucleotides for replication. Some development terms (brain, liver) may reflect broad or secondary annotations rather than core function, so the link is not tissue-specific but functionally connected to nucleotide supply for replication.","confidence":"Medium","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046939","count":3},{"id":"GO:0046940","count":3},{"id":"GO:0006270","count":2},{"id":"GO:0046041","count":2},{"id":"GO:0007420","count":2}]},{"hash":"1620167059035628","title":"Calcium-Triggered Exocytosis","description":"Dominant GO terms point to calcium-triggered secretion, including fast calcium-dependent neurotransmitter exocytosis as well as insulin and dopamine secretion regulation, suggesting a common theme of calcium-driven secretory processes in neural and endocrine cells. A few terms (iron-sulfur cluster assembly, ribophagy) appear less directly related, so the label emphasizes the secretory pathway axis.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032024","count":2},{"id":"GO:0016226","count":1},{"id":"GO:0032259","count":1},{"id":"GO:0014059","count":1},{"id":"GO:0060548","count":1}]},{"hash":"353469305694190021","title":"Vacuolar ion transport and acidification","description":"The GO terms cluster around vacuolar processes (vacuolar acidification; protein targeting to vacuole; vacuole organization) and membrane/ion transport (proton transmembrane transport; sodium transport; copper ion homeostasis; proton motive force-driven ATP synthesis), pointing to a theme of vacuolar proton transport and ion homeostasis; a few terms on endodermal differentiation and L-ascorbic acid metabolism are broader and less specific to vacuole function.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007035","count":1},{"id":"GO:0006626","count":1},{"id":"GO:0015991","count":1},{"id":"GO:0006623","count":1},{"id":"GO:0006878","count":1}]},{"hash":"891059848186030613","title":"Endosome-Golgi-Vacuole trafficking","description":"This cluster centers on intracellular transport within the endomembrane system: transitions between Golgi, early and late endosomes, and delivery to the vacuole, including the multivesicular body pathway and endocytosis. Taken together, the proteins likely function in endosome-to-Golgi and Golgi-to-endosome recycling and vacuolar protein sorting.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000147","count":3},{"id":"GO:0032511","count":2},{"id":"GO:0006895","count":2},{"id":"GO:0007565","count":2},{"id":"GO:0015032","count":2}]},{"hash":"1759206823202181374","title":"Membrane Ion Transport and Membrane Potential Regulation","description":"The top GO terms point to proton transport, various anion transport (chloride, sulfate, oxalate), and regulation of membrane potential, along with related processes like intracellular pH elevation and gastric acid secretion. This ensemble suggests a cluster of proteins involved in membrane transport and ion homeostasis, rather than a single signaling or transcription pathway; some terms like sperm capacitation or sensory perception of sound may be incidental annotations. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0015991","count":3},{"id":"GO:0042391","count":2},{"id":"GO:0048240","count":2},{"id":"GO:0007605","count":2}]},{"hash":"648552801348200845","title":"Bacterial sugar catabolism and carbohydrate metabolism","description":"Most terms cluster around catabolism and processing of various carbohydrates (arabinose, gluconate, xylulose, rhamnose) and related phosphorylation steps, plus glycerol-3-phosphate biosynthesis linked to carbohydrate metabolism. A few terms (cellular response to interleukin-13, xenobiotic stimulus, quorum sensing) appear tangential or broader in scope, but the dominant signal is sugar metabolism.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":3},{"id":"GO:0042493","count":2},{"id":"GO:0046167","count":2},{"id":"GO:0035963","count":2},{"id":"GO:0019640","count":2}]},{"hash":"936582969892516615","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0071897","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0046038","count":2}]},{"hash":"790228570669095875","title":"Neural development and balance/vestibular function","description":"The terms point to neural tissue development (hindbrain development, neural crest cell development, righting reflex, neuromuscular balance) and related reflex and balance functions, with supporting metabolic processes (retinal metabolism, glucosylceramide metabolism). While a few entries are broader or metabolic, the dominant theme is neural development linked to balance and vestibular/neural reflex roles, justifying this labeled cluster.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060013","count":5},{"id":"GO:0030902","count":5},{"id":"GO:0006678","count":5},{"id":"GO:0019544","count":5},{"id":"GO:0019285","count":5}]},{"hash":"1060130512009313233","title":"Muscle membrane transport and T-tubule organization","description":"This cluster centers on terms involving maintaining transmembrane electrochemical gradients, ion transport (potassium and zinc), and T-tubule organization, plus heart-related signaling, which together point to functions in excitable muscle cell membranes (cardiac/skeletal) where ion flux and T-tubule structure are crucial. Some terms (e.g., testosterone response) are less central and may reflect broader signaling connections, but the strongest theme is muscle membrane transport and architecture.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901205","count":2},{"id":"GO:1903249","count":2},{"id":"GO:0010248","count":2},{"id":"GO:0033574","count":2},{"id":"GO:0033292","count":2}]},{"hash":"1185106819189586659","title":"Negative Regulators of Developmental Signaling","description":"The cluster centers on GO terms for negative regulation of multiple signaling pathways (ERK cascade, GTPase activity, Ras signaling, FGF receptor signaling) alongside several developmental processes (ureteric bud development, organ induction, axon development, lung branching). This suggests these proteins act as inhibitors that modulate signaling during development, rather than core components, so the label emphasizes both the regulatory role and the developmental context.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":1},{"id":"GO:0034260","count":1},{"id":"GO:0040037","count":1},{"id":"GO:0001657","count":1},{"id":"GO:0001759","count":1}]},{"hash":"439675961513057908","title":"Unknown","description":"The Top Terms list is highly heterogeneous, spanning lipid droplet organization, protein secretion, viral latency and genome activation, protein folding, host entry, RNA-templated DNA biosynthesis, leukocyte migration, and even plant sepal formation. With no clear shared function or pathway and no edges connecting the proteins, there isn\u2019t a coherent theme to name this cluster beyond Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034389","count":1},{"id":"GO:0050714","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0010849","count":1},{"id":"GO:0044829","count":1}]},{"hash":"1300769015233783935","title":"RNA processing and splicing machinery","description":"This cluster is dominated by terms for mRNA splicing via the spliceosome, spliceosomal snRNP assembly, tRNA processing, and rRNA maturation, with P-body assembly also tied to RNA metabolism; together they point to RNA processing/splicing as the core function.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":3},{"id":"GO:0009414","count":2},{"id":"GO:0008334","count":2},{"id":"GO:0030490","count":2},{"id":"GO:0070317","count":2}]},{"hash":"152144429975301266","title":"ER quality control and stress response","description":"The top GO terms cluster around the endoplasmic reticulum: ubiquitin-dependent ERAD pathway, ER overload response (ER stress), and ER organization, indicating a shared role in ER maintenance and stress signaling. The osteoblast differentiation term is less connected and may reflect annotation noise or pleiotropy; the dominant signal is ER-related protein quality control and stress response.","confidence":"Medium","size":5,"edges":6,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":1},{"id":"GO:0006983","count":1},{"id":"GO:0007029","count":1},{"id":"GO:0001649","count":1}]},{"hash":"579298950187197001","title":"Antiviral dsRNA and interferon response","description":"The top GO terms point to antiviral defense, dsRNA sensing, and type I interferon signaling, indicating an innate immune response pattern. Some terms related to development or other processes likely reflect background annotations, but the dominant theme is antiviral/dsRNA\u2013driven signaling and associated stress responses.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050689","count":2},{"id":"GO:0071360","count":2},{"id":"GO:0003283","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0070301","count":1}]},{"hash":"2027606846526621713","title":"Calcium-Driven Muscle Signaling","description":"This cluster centers on calcium signaling in muscle contexts: ryanodine receptor\u2013mediated calcium release, regulation of postsynaptic calcium concentration, skeletal muscle fiber development, and cardiac muscle hypertrophy in response to stress. While some terms are obsolete or less related (immune regulation, miRNA processing), the dominant GO terms point to calcium-dependent signaling and muscle development/adaptation, supporting a cohesive muscle-calcium theme.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001915","count":5},{"id":"GO:0051343","count":5},{"id":"GO:0032516","count":5},{"id":"GO:1901901","count":5},{"id":"GO:0060316","count":5}]},{"hash":"131390769156555475","title":"Diverse Membrane Transport of Ions and Metabolites","description":"This cluster is dominated by transmembrane transport terms for a variety of substrates (nitrate, nitrite, potassium ions, sialic acid, arabinose, vitamins) and vesicular transport (neurotransmitter loading), suggesting the proteins are primarily membrane transporters handling diverse ions and metabolites. A few terms (innate immune response, fucose metabolism) are present but do not override the central theme of transport across membranes.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0006004","count":1},{"id":"GO:0042891","count":1},{"id":"GO:0098700","count":1},{"id":"GO:0015707","count":1}]},{"hash":"1915570961522933372","title":"Actin Cytoskeleton Remodeling and Cell Morphogenesis","description":"This cluster emphasizes actin cytoskeleton dynamics, with Arp2/3-mediated actin nucleation, actin filament bundle assembly, and regulation of endocytosis, along with terms for cell polarity and cell shape maintenance. The tissue development terms (substantia nigra and skeletal muscle fiber development) and platelet aggregation further reflect roles of actin remodeling across contexts, supporting a theme of cytoskeletal-driven morphogenesis.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009825","count":5},{"id":"GO:0021762","count":5},{"id":"GO:0043486","count":5},{"id":"GO:0030100","count":5},{"id":"GO:0051017","count":5}]},{"hash":"2240358200081646593","title":"Mesoderm Development and Cellular Transport","description":"The top GO terms point to developmental processes (mesoderm development and gastrulation) as a unifying theme, with additional signals of intracellular trafficking (ER to Golgi vesicle transport) and core cellular activities (DNA replication, carbohydrate metabolism). This suggests the proteins may participate in early development alongside essential cellular processes, rather than a single specialized pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007498","count":2},{"id":"GO:0007369","count":2},{"id":"GO:0070262","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1129713637976658990","title":"Innate Immunity and Coagulation","description":"The top GO terms cluster around complement activation (classical pathway), neutrophil-mediated killing, leukocyte tethering or rolling, and Factor XII activation, which together point to innate immune responses and the coagulation cascade. While there are a few terms related to tissue remodeling (elastin catabolic process) and signaling (Wnt), the strongest signal centers on immune and coagulation functions, justifying this label as a concise representation of the cluster\u2019s theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0003050","count":3},{"id":"GO:0042127","count":2},{"id":"GO:1903238","count":2}]},{"hash":"2235710902889958930","title":"Angiogenesis and vascular morphogenesis via RTKs","description":"The cluster\u2019s GO terms are dominated by endothelial signaling, including VEGF and PDGF receptor pathways, and activation of receptor tyrosine kinases, along with endothelial chemotaxis and diverse vascular morphogenesis (retina, renal arteries). The presence of terms on hair cell differentiation and smoothened signaling suggests broader developmental coordination, but the core theme centers on RTK-driven angiogenesis and vascular development.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0035767","count":1},{"id":"GO:0007171","count":1},{"id":"GO:0048903","count":1},{"id":"GO:0061299","count":1}]},{"hash":"1023234827394854302","title":"Angiogenesis and vascular morphogenesis","description":"This cluster centers on endothelial signaling and vascular development, with terms like endothelial chemotaxis, VEGF and PDGF receptor signaling, and morphogenesis of retinal and renal vasculature, pointing to a common role in angiogenesis and vascular formation across tissues. Some terms reflect broader developmental signaling, but the dominant theme is blood vessel formation and organ vasculature morphogenesis.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0035767","count":1},{"id":"GO:0007171","count":1},{"id":"GO:0048903","count":1},{"id":"GO:0061299","count":1},{"id":"GO:0045880","count":1}]},{"hash":"1877678207365405074","title":"Vesicle trafficking in neural development","description":"The prominent terms indicate vesicle trafficking functions: regulation of COPII vesicle coating, ER-to-Golgi vesicle transport, and regulation of synaptic vesicle exocytosis, pointing to intracellular transport activities with a neural context (brain development). Some terms appear unrelated or obsolete, but overall the cluster centers on vesicle trafficking linked to neural development.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010796","count":4},{"id":"GO:2000300","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0031384","count":4},{"id":"GO:0003400","count":4}]},{"hash":"226615875298888868","title":"Neural development and transcriptional regulation","description":"The top terms center on brain and forebrain development alongside DNA-templated transcription, suggesting a core role in neural gene expression; additional terms point to cell cycle control, nuclear transport, ribosome biogenesis, and cytoskeletal remodeling, indicating coordinated growth and neural progenitor function. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0061099","count":1},{"id":"GO:1901976","count":1},{"id":"GO:0035264","count":1}]},{"hash":"467801122937898265","title":"Angiogenesis and Neural Morphogenesis","description":"The proteins are enriched for vascular development signaling (PDGF and VEGF receptor pathways, endothelial chemotaxis, vascular/retina/artery morphogenesis) and neural/sensory development (hair cell differentiation, axonogenesis), suggesting a shared developmental program coordinating blood vessel and nervous system formation.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048008","count":5},{"id":"GO:0035767","count":4},{"id":"GO:0007171","count":4},{"id":"GO:0048903","count":4},{"id":"GO:0061299","count":4}]},{"hash":"1211896933725986175","title":"Innate immune signaling","description":"The cluster\u2019s top GO term is innate immune response (GO:0045087), with three proteins annotated, suggesting a primary link to innate immune pathways. Other frequent terms touch on NF-kappaB transcription factor activity regulation (obsolete) and cytoskeletal/trafficking associations (protein localization to microtubule), implying a cluster of proteins involved in signaling that interfaces with cytoskeletal dynamics. While some terms are broader (e.g., responses to vitamin D or salicylic acid), the strongest signal centers on innate immune signaling, making this a concise and representative label.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0035372","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0031532","count":2}]},{"hash":"2034598949391862947","title":"Unknown","description":"The GO terms span diverse processes (cell adhesion, ion homeostasis, sensory perception like taste and temperature, vitamin K response, chemokine production, and general cell proliferation) with no clear single biological theme tying them together, so a concise, representative label cannot be determined.","confidence":"","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":1},{"id":"GO:0071307","count":1},{"id":"GO:0008283","count":1},{"id":"GO:1904209","count":1},{"id":"GO:0055078","count":1}]},{"hash":"602813793179899436","title":"DNA Replication and Repair Machinery","description":"The proteins in this cluster are strongly associated with DNA replication and multiple DNA repair pathways (base-excision repair, nucleotide-excision repair, RNA primer removal), as well as processes that maintain genome integrity such as recombination resolution and spindle checkpoint regulation. This cohesive pattern points to a core set of factors involved in replication fidelity and genome maintenance, justifying the label.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":1},{"id":"GO:0035753","count":1},{"id":"GO:0031292","count":1},{"id":"GO:0016446","count":1},{"id":"GO:0006284","count":1}]},{"hash":"55538690279998694","title":"Glutamatergic Synaptic Transmission and Plasticity","description":"GO terms cluster around excitatory synaptic signaling, memory-related processes, and long-term plastic changes, including glutamatergic transmission, learning-associated memory, and regulation of synaptic plasticity, suggesting a module of learning-related neuronal signaling.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072375","count":2},{"id":"GO:0010226","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0001661","count":2},{"id":"GO:0050806","count":2}]},{"hash":"1241637923062777960","title":"Intestinal lipid absorption and fatty acid metabolism","description":"This cluster centers on lipid handling in the gut and fatty acid processing: terms for intestinal absorption, bile acid metabolism, long-chain fatty acid transport, triglyceride catabolism, and positive regulation of fatty acid beta-oxidation. The presence of these lipid- and transport-related terms suggests a cohesive theme around lipid uptake and oxidation, with ancillary terms like hypoxia response and detoxification being less central. The connectivity among the proteins supports a lipid metabolic module.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050892","count":1},{"id":"GO:0008206","count":1},{"id":"GO:0098869","count":1},{"id":"GO:0019433","count":1},{"id":"GO:0051345","count":1}]},{"hash":"1591713476207001051","title":"Unknown","description":"The top GO terms span insect cuticle development, immune cell activities, digestion, and signaling with no shared functional theme or interaction pattern among the four proteins, making a coherent label unlikely. Therefore, the cluster is best labeled Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0042127","count":1},{"id":"GO:1903238","count":1},{"id":"GO:0060309","count":1},{"id":"GO:0002542","count":1}]},{"hash":"2110552414831811246","title":"Cold-induced pexophagy","description":"Top GO terms point to peroxisome autophagy (pexophagy), transport, and freezing response, suggesting a process where peroxisome turnover via autophagy occurs under cold stress, with vesicle transport facilitating autophagosome formation and organelle delivery. The strongest, cohesive theme is pexophagy activated by cold, hence the label Cold-induced pexophagy.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006810","count":1},{"id":"GO:0050826","count":1},{"id":"GO:0030242","count":1}]},{"hash":"71359989820658798","title":"Actin remodeling and cell polarity","description":"GO terms indicate strong enrichment for actin cytoskeleton dynamics (Arp2/3 complex\u2013mediated actin nucleation; actin filament bundle assembly) and regulation of cell shape/polarity, with endocytosis linked to actin remodeling. Some developmental terms appear, but the dominant signal centers on actin-driven morphogenesis and polarity. Confidence: High","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009825","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0043486","count":2},{"id":"GO:0030100","count":2},{"id":"GO:0051017","count":2}]},{"hash":"1724981558727070857","title":"Chromatin assembly and heterochromatin organization","description":"This cluster\u2019s top GO terms are dominated by chromatin-related processes: nucleosome assembly, establishment of protein localization to chromatin, and heterochromatin organization. They also include terms about nucleus size regulation and histone modifications, reinforcing a chromatin/nuclear theme. A couple of terms touch on ribosome biogenesis/translation, which may reflect nucleolar involvement that can accompany chromatin dynamics, but the strongest signal is chromatin organization. Confidence: Medium","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":2},{"id":"GO:0098532","count":2},{"id":"GO:0071169","count":2},{"id":"GO:0016584","count":2},{"id":"GO:0080182","count":2}]},{"hash":"983883504068514684","title":"Transmembrane Transport Proteins","description":"The top GO terms are all about moving substances across membranes, including various ions and small molecules (nitrate, nitrite, phosphate, sodium, potassium, galactose, arabinose) and even neurotransmitter loading into synaptic vesicles. This coherence points to a shared role as membrane transporters rather than others, so a label highlighting transmembrane transport is most representative.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0015739","count":4},{"id":"GO:0035435","count":4},{"id":"GO:0098700","count":4}]},{"hash":"1785037475044691727","title":"Liver Regeneration and Coagulation","description":"The GO terms are dominated by liver-related processes (liver regeneration, negative regulation of hepatocyte proliferation, ECM secretion, fibrinolysis, and blood coagulation), suggesting a hepatic injury response and remodeling/hemostasis cluster. Some terms about stress responses (heat, glucose) appear, but the strongest signal centers on liver repair and coagulation pathways.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0021702","count":3},{"id":"GO:2000346","count":3},{"id":"GO:0003331","count":3},{"id":"GO:0097421","count":3},{"id":"GO:0007596","count":3}]},{"hash":"1685333761972720657","title":"Unknown","description":"The top terms span a wide and unrelated range of processes (chaperone regulation, kinase activity, cell cycle checkpoints, growth, nuclear pore localization, ribosome biogenesis, actin nucleation, development, and signaling). There is no clear shared function or pathway connecting all four proteins, and the network shows no edges, so a coherent label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090035","count":1},{"id":"GO:0061099","count":1},{"id":"GO:1901976","count":1},{"id":"GO:0035264","count":1},{"id":"GO:0030433","count":1}]},{"hash":"276855779066503915","title":"Neural development and neuron differentiation","description":"This cluster's top GO terms are dominated by neural development processes (facial nucleus development, midbrain-hindbrain boundary development, spinal cord motor neuron fate specification, Purkinje cell differentiation), suggesting a cohesive theme of CNS development and neuron specification. Some terms (cartilage development, heart-related fate) indicate broader developmental roles but do not undermine the neural-focused signal.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021754","count":3},{"id":"GO:0060021","count":3},{"id":"GO:0030917","count":3},{"id":"GO:0021520","count":3},{"id":"GO:0035116","count":3}]},{"hash":"1575852176483433703","title":"Membrane-Associated Signaling and Adhesion","description":"GO terms emphasize membrane-related regulation and adhesion: receptor internalization, raft localization, cell junction/adhesion, axonogenesis, and podocyte development, plus APP processing and IL-2 production. This hints at a shared theme of membrane-domain\u2013associated signaling and cell\u2013cell interactions across different tissues, justifying a membrane signaling/adhesion label.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002090","count":1},{"id":"GO:1902992","count":1},{"id":"GO:0060355","count":1},{"id":"GO:0007409","count":1},{"id":"GO:1901890","count":1}]},{"hash":"878923645514964409","title":"Dopamine release and neural signaling regulation","description":"The top GO terms include regulation of dopamine secretion and fast, calcium-dependent exocytosis of neurotransmitter, pointing to a neural signaling and neurotransmitter release theme. Negative regulation of ERK1/ERK2 cascade also aligns with signaling control in neurons. However, other terms reflect broad cellular processes (apoptosis, cell cycle, rRNA processing, nuclear localization), suggesting the cluster may include proteins with broader regulatory roles beyond neural signaling. Overall, the most representative shared function appears to be neural signaling and dopamine exocytosis, though the connection is not exclusive.","confidence":"Low","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0070373","count":1},{"id":"GO:0014059","count":1},{"id":"GO:1901315","count":1}]},{"hash":"1004346045025518862","title":"Developmental Cell Adhesion and Morphogenesis","description":"These proteins appear linked to developmental and morphogenetic processes, with GO terms for brain development and multicellular organism growth, plus functions in cell movement and adhesion (lamellipodium assembly, actin cytoskeleton reorganization, epithelial cell\u2013cell adhesion) and vesicle exocytosis. Endothelial lumen formation and lymphocyte aggregation further point to tissue organization and intercellular interactions during development, suggesting a theme of developmental cell adhesion and morphogenesis driven by cytoskeletal remodeling.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0031384","count":4},{"id":"GO:0010796","count":4},{"id":"GO:2000300","count":4},{"id":"GO:0031532","count":3}]},{"hash":"2252757440202772445","title":"Translation initiation and mRNA processing","description":"The top GO terms cluster around translation initiation (EIF4F complex assembly, preinitiation complex formation, regulation of translational initiation) together with mRNA stability and processing (stabilization and splicing), suggesting these proteins function together to initiate translation and regulate mRNA fate.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0097010","count":3},{"id":"GO:0010610","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0006446","count":3}]},{"hash":"1522479519391201398","title":"Clathrin-Dependent Endocytosis and Vesicle Trafficking","description":"The top GO terms cluster around clathrin-mediated endocytosis, clathrin coat assembly, and vesicle trafficking between endosomes and the Golgi, as well as cargo loading, suggesting a shared role in clathrin-dependent vesicle formation and trafficking. Although a few terms pertain to broader signaling or metal ion transport, the dominant theme is endocytosis regulation via the clathrin pathway.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902961","count":1},{"id":"GO:0048261","count":1},{"id":"GO:2000369","count":1},{"id":"GO:0009997","count":1},{"id":"GO:0048268","count":1}]},{"hash":"285478511717421718","title":"Broad Regulators of Cellular Processes","description":"The GO terms show regulatory roles across many distinct processes (translation, innate immune signaling, endocytosis, metabolism, mitochondrial fusion, cardiac contraction, action potential, ER stress-induced apoptotic signaling, and transcription). No single pathway dominates, so the cluster seems to consist of proteins that modulate multiple processes rather than a dedicated enzymatic function. Hence a broad regulatory label is appropriate.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0034140","count":4},{"id":"GO:0051865","count":4},{"id":"GO:1900186","count":4},{"id":"GO:0033132","count":4}]},{"hash":"696115915278690508","title":"Bacterial cell wall biosynthesis","description":"The top GO terms point to building and organizing the bacterial cell envelope, including peptidoglycan biosynthetic process, lipoteichoic acid biosynthetic process, and cell wall organization. While there are a few seemingly unrelated terms (e.g., certain metabolic or signaling processes), the strongest shared theme across the annotations is synthesis and maintenance of the cell wall.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0005975","count":3},{"id":"GO:0009252","count":2},{"id":"GO:0033330","count":2},{"id":"GO:0033303","count":2},{"id":"GO:0051301","count":2}]},{"hash":"2217381760828412442","title":"Unknown","description":"The top GO terms span many unrelated processes (transcription, kinetochore localization, CDK regulation, actin remodeling, axonogenesis, lipid catabolism, protein binding, T cell signaling, gene silencing, and apoptosis) with no clear common theme, and there are no interactions among the proteins, so a cohesive functional label is not supported.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0034501","count":3},{"id":"GO:0045736","count":3},{"id":"GO:0031532","count":2},{"id":"GO:0007409","count":2}]},{"hash":"1398876344520785132","title":"Unknown","description":"The top GO terms suggest conflicting, unrelated functions (face morphogenesis vs. mitophagy) and there are no interactions among the proteins (Edges 0, Triangles 0, Max Degree 0), so there isn't a cohesive function to label the cluster beyond Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":1},{"id":"GO:0000422","count":1}]},{"hash":"1713972283055615012","title":"Unknown","description":"Top terms point to several unrelated areas: neuronal development and cytoskeletal remodeling, immune signaling, GPCR signaling regulation, and apoptosis. There is no single shared function that ties all four proteins together, so a cohesive label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031532","count":3},{"id":"GO:0007409","count":3},{"id":"GO:0010898","count":3},{"id":"GO:0032092","count":3},{"id":"GO:0050852","count":3}]},{"hash":"701801363314255311","title":"Cajal body RNA localization and chaperone activity","description":"This cluster\u2019s top GO terms point to a strong emphasis on Cajal bodies, with scaRNA localization and positive regulation of protein localization to Cajal bodies, indicating a role in nuclear RNA processing and RNP biogenesis. It also includes chaperone-mediated protein folding and complex assembly terms, suggesting accompanying chaperone activity. Immune-related terms (inflammatory response, IL-6 production, IgG isotype switching) are present but appear peripheral to the core nuclear RNA-processing theme.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1904871","count":4},{"id":"GO:0051086","count":4},{"id":"GO:0050729","count":4},{"id":"GO:0048291","count":4},{"id":"GO:0090666","count":4}]},{"hash":"1438339630390411810","title":"Ubiquitin-Proteasome-Mediated Degradation","description":"The cluster shows strong enrichment for ubiquitination and proteasome-related processes (polyubiquitination, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process) and a cellular response to cadmium\u2014together pointing to proteostasis and targeted protein degradation as the shared function of these proteins.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0061099","count":1}]},{"hash":"1005965994848741333","title":"Innate Immune Defense and Tissue Remodeling","description":"The top GO terms point strongly to innate immune activities (defense against Gram-positive bacteria, neutrophil-mediated killing, leukocyte recruitment) and extracellular matrix remodeling (plasminogen activation, elastin catabolic process). While there are also growth and transcription regulation terms, the dominant theme is inflammation-driven defense combined with proteolytic remodeling, suggesting an innate immune/remodeling cluster rather than a single narrowly defined pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0031639","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0042127","count":1}]},{"hash":"685781746821628924","title":"Unknown","description":"The GO terms are highly diverse (ribosome assembly, rRNA export, shoot/limb development, transcription, meiosis, cell adhesion) with no single shared function or dominant biological theme, so a cohesive label cannot be confidently assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000032","count":1},{"id":"GO:0000028","count":1},{"id":"GO:0006407","count":1},{"id":"GO:0090506","count":1},{"id":"GO:0031581","count":1}]},{"hash":"236498865946826824","title":"Arabinogalactan Protein and Mucilage Biosynthesis","description":"The top GO terms cluster around arabinogalactan protein (AGP) metabolism and related glycosylation processes (AGP metabolic process, O-linked glycosylation via hydroxyproline, poly-N-acetyllactosamine biosynthetic process), plus mucilage and root hair/mucilage-related plant development (root hair cell development, mucilage biosynthetic process, seed coat mucilage). This combination points to plant cell wall glycoprotein production and secretion, particularly AGPs and associated polysaccharides. Some terms appear non-plant or cross-species in origin, but the dominant signal is plant AGP/glycosylation and mucilage biosynthesis. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":1},{"id":"GO:0080147","count":1},{"id":"GO:0010405","count":1},{"id":"GO:0001744","count":1},{"id":"GO:0010493","count":1}]},{"hash":"2107722721050627512","title":"Unknown","description":"The GO terms across the four proteins are highly diverse, spanning receptor tyrosine kinase signaling, TLR signaling, axonogenesis, cytokine signaling, Wnt signaling, mitochondrial fission, bone and floral development, apoptosis, and more. There is no single coherent function uniting these terms, so a specific, intuitive name cannot be assigned.","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007169","count":1},{"id":"GO:0034134","count":1},{"id":"GO:0007409","count":1},{"id":"GO:0009620","count":1},{"id":"GO:1904887","count":1}]},{"hash":"731818340732848276","title":"GPCR Signaling and Dopamine Regulation","description":"Most terms describe G protein-coupled receptor (GPCR) signaling, including adenylate cyclase-activating/inhibiting pathways, GPCR internalization/desensitization, and regulation of dopamine secretion. Adrenergic/phospholipase C\u2013activating pathways and photoreceptor maintenance also point to GPCR roles in neural/retinal contexts and blood pressure regulation. Some outliers (electron transport chain, reproduction) are less central but do not override the core GPCR theme. Confidence: High.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045777","count":3},{"id":"GO:0022900","count":3},{"id":"GO:0010579","count":3},{"id":"GO:0031635","count":2},{"id":"GO:0002032","count":2}]},{"hash":"338125503420105517","title":"Spinal cord development and NMDA receptor signaling","description":"The dominant GO terms point to neural development and synaptic signaling: spinal cord development and patterning, ventral spinal cord development, NMDA receptor clustering, regulation of NMDA receptor activity, and positive regulation of excitatory postsynaptic potential, with reelin-mediated signaling reinforcing neuronal migration pathways. A few terms like defense response to protozoan or endothelial tube extension appear less related and may reflect annotation noise, but the core theme is neural development and NMDA receptor\u2013mediated signaling.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042832","count":2},{"id":"GO:0097498","count":2},{"id":"GO:0090051","count":2},{"id":"GO:0048265","count":1},{"id":"GO:0097114","count":1}]},{"hash":"1765849768174534669","title":"Cell Cycle and DNA Replication","description":"The cluster is dominated by cell cycle processes: meiotic/mitotic cell cycle terms, DNA replication, G1/S transition, and kinetochore localization, indicating these proteins participate in chromosome duplication and segregation. A few terms touch nerve development, but the strongest signal is cell cycle machinery.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051321","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0042220","count":3},{"id":"GO:0000082","count":3},{"id":"GO:0014044","count":3}]},{"hash":"880760301233405451","title":"Golgi-ER vesicle trafficking","description":"These proteins are annotated with GO terms centered on Golgi vesicle budding, endocytosis, and retrograde transport from the Golgi to the ER, suggesting a shared role in vesicle trafficking through the Golgi network and related internalization pathways. Other terms in the list appear less connected and may reflect broader annotations or noise. Overall, the cluster most likely represents components involved in Golgi-to-ER vesicle trafficking and endocytic processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048194","count":2},{"id":"GO:0006897","count":2},{"id":"GO:0006890","count":2},{"id":"GO:0046677","count":2},{"id":"GO:1901205","count":1}]},{"hash":"1020669412921613122","title":"Apoptosis and Immune Signaling","description":"This cluster shows strong enrichment for apoptosis-related processes (mitochondrial membrane permeability involved in apoptotic process and general apoptotic process) and immune signaling (T cell receptor signaling pathway, mast cell cytokine production, GPCR desensitization). This combination suggests proteins that participate in regulated cell death with communication to the immune system, rather than a single, isolated function. Some terms like axonogenesis or actin cytoskeleton reorganization may reflect multifunctionality or context-specific roles across cell types. Overall, the dominant theme appears to be links between apoptosis and immune signaling.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031532","count":4},{"id":"GO:1902108","count":4},{"id":"GO:0007409","count":4},{"id":"GO:0010898","count":4},{"id":"GO:0032092","count":4}]},{"hash":"1322128588720323549","title":"Stress-response DNA repair and proteostasis","description":"This cluster centers on DNA damage handling and protein quality control, with GO terms for nonhomologous end joining repair and apoptotic process, plus ubiquitin-proteasome/ERAD\u2013related pathways and proteasome localization. Immune signaling terms (IL-1 response, T cell signaling) and other stress-related terms suggest a broader stress-response theme, though some annotations (ABA response, retinal apoptosis) may reflect cross-species or noisy annotations. Overall, the proteins seem connected through a common theme of stress-induced genome maintenance and proteostasis leading to apoptosis when damage is unresolved.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0006303","count":4},{"id":"GO:0071347","count":4},{"id":"GO:0030433","count":4},{"id":"GO:1901694","count":4},{"id":"GO:1990920","count":4}]},{"hash":"227665613255165578","title":"Neurodevelopment and Cell Proliferation","description":"This cluster centers on neural development signals (forebrain development, neural tube closure, skeletal system development) alongside basic cell cycle and mitosis (cell division, mitotic cell cycle) and transcriptional regulation (DNA-templated transcription), suggesting a role in developmental programs that require coordinated cell proliferation and gene expression. Some stress/defense terms appear incidental to the core theme. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030900","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0001403","count":2},{"id":"GO:0050830","count":2}]},{"hash":"133152960494796299","title":"Translation and tRNA wobble modification","description":"The Top Terms show translation (GO:0006412) and tRNA wobble uridine modification (GO:0002098) as the most specific shared functions among the proteins, suggesting a core link to translation-related processes and tRNA modification. Other terms appear singly and may reflect broader cellular contexts or annotation noise. The lack of edges indicates a loosely connected set, reinforcing a focal theme around translation-related activity rather than a single pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0009933","count":1},{"id":"GO:0002098","count":1},{"id":"GO:0016311","count":1},{"id":"GO:0016049","count":1}]},{"hash":"2251833680645647315","title":"Ubiquitin-Proteasome Regulation of Immune Signaling","description":"These proteins are linked by ubiquitin-dependent protein degradation (including proteasome-mediated pathways and autoubiquitination) and involvement in immune signaling pathways (non-canonical NF-kappaB, IL-17 signaling, defense against virus, and T cell homeostasis). The common theme is ubiquitin-proteasome control of immune signaling processes.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0048822","count":1},{"id":"GO:0043161","count":1},{"id":"GO:0033033","count":1},{"id":"GO:0045721","count":1}]},{"hash":"1155783204612067719","title":"T Cell Homeostasis and Cytotoxicity Regulation","description":"Most frequent terms are GO:0043029 (T cell homeostasis) and GO:0001915 (negative regulation of T cell mediated cytotoxicity), indicating immune-regulatory function. Other terms include obsolete or non-specific terms (muscle development, calcium regulation) that seem peripheral to the core signal. Therefore the cluster is best described as immune regulatory, focused on T cell homeostasis and suppression of cytotoxic activity.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0043029","count":4},{"id":"GO:0001915","count":3},{"id":"GO:0051343","count":3},{"id":"GO:0032516","count":3},{"id":"GO:1901901","count":3}]},{"hash":"752020454342055058","title":"Neuronal signaling and synaptic regulation","description":"The cluster\u2019s GO terms are dominated by neural-related processes: glutamate secretion, long-term synaptic depression, and regulation of serotonin uptake, all pointing to synaptic function and neurotransmission. Supporting terms about cell polarity and adherens junctions suggest connectivity and organization relevant to synapse formation and neuronal development, but the strongest signal comes from neurotransmitter handling and synaptic modulation. Overall, the proteins appear to cluster around neuronal signaling and synaptic regulation, with ancillary links to cellular localization and polarity. ","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2000009","count":4},{"id":"GO:0014047","count":4},{"id":"GO:0045186","count":4},{"id":"GO:0051612","count":4},{"id":"GO:1903361","count":4}]},{"hash":"2157392420970972822","title":"Neural apoptosis and forebrain development","description":"The top GO terms are dominated by neuron and glial apoptotic processes and forebrain development, indicating a neural-development/apoptosis theme for this cluster. Supporting terms cover signaling and cellular maintenance but do not outweigh the neural focus, so this label reflects the core function of the proteins in the set.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051402","count":3},{"id":"GO:0034349","count":3},{"id":"GO:0061099","count":2},{"id":"GO:1901976","count":2},{"id":"GO:0035264","count":2}]},{"hash":"109090625958972959","title":"Hindbrain and craniofacial neural development","description":"The top GO terms cluster around neural and craniofacial development: inner ear development, facial nucleus and rhombomere formation, spinal motor neuron fate, and Purkinje cell differentiation, all pointing to hindbrain patterning and craniofacial/neural tissue differentiation. A couple of terms touch cartilage or heart development, but the dominant signal is neural development and hindbrain-related patterning.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048839","count":4},{"id":"GO:0021754","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0030917","count":2},{"id":"GO:0021520","count":2}]},{"hash":"1228525195764265097","title":"Immune-Neural Signaling and Cytoskeleton","description":"Top terms show immune signaling (T cell receptor signaling, mast cell cytokine production), neural processes (axonogenesis, regulation of synaptic plasticity), along with actin cytoskeleton reorganization and GPCR signaling modulation. The proteins in this cluster seem to participate in broad signal transduction coupled to cytoskeletal remodeling across immune and nervous system contexts, rather than a single cohesive function.","confidence":"Low","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031532","count":4},{"id":"GO:0007409","count":4},{"id":"GO:0010898","count":4},{"id":"GO:0032092","count":4},{"id":"GO:0050852","count":4}]},{"hash":"1260104391531922555","title":"DNA Damage Response and Repair","description":"Despite a small protein set, the top GO terms cluster around DNA repair and recombination (base-excision repair, DNA recombination, DNA catabolic process) together with apoptotic and oxidative stress responses (cell redox homeostasis, response to hydrogen peroxide) and cell cycle regulation (positive regulation of G1/S transition). This combination points to a function in DNA damage response and maintenance, coordinating repair with cell cycle progression under oxidative stress.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1900087","count":2},{"id":"GO:0071375","count":1},{"id":"GO:0006310","count":1},{"id":"GO:0006284","count":1},{"id":"GO:0007568","count":1}]},{"hash":"1432885550430288205","title":"Membrane Transport of Ions and Small Molecules","description":"Based on the GO terms, the proteins are linked to movement of diverse solutes across membranes, including sodium-dependent organic cation transport, dehydroascorbic acid transport, nitrate/ potassium/ phosphate ion transport, sialic acid and selenite transport. Although there are a couple of biosynthetic terms present, the dominant theme is transmembrane transport of nutrients and ions, which justifies a transporter-focused label.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019852","count":3},{"id":"GO:0070715","count":3},{"id":"GO:0070837","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0071805","count":3}]},{"hash":"1341526042687211184","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0034247","count":1},{"id":"GO:0008033","count":1},{"id":"GO:0035900","count":1},{"id":"GO:0070292","count":1},{"id":"GO:1903999","count":1}]},{"hash":"579977848971426433","title":"Plant nitrate and peptide transport with hormone signaling","description":"The top GO terms cluster around dipeptide/oligopeptide transport and nitrate transport/assimilation, alongside auxin signaling and gibberellin homeostasis, plus herbicide response. This suggests a cohesive plant-specific function integrating nutrient transport with hormone-regulated signaling; the other terms appear as ancillary processes.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042938","count":2},{"id":"GO:0010167","count":2},{"id":"GO:0009734","count":2},{"id":"GO:0035672","count":2},{"id":"GO:0042128","count":2}]},{"hash":"563927046660844658","title":"ER protein folding and ER stress response","description":"This cluster is dominated by GO terms tied to endoplasmic reticulum folding/refolding, handling of misfolded proteins, ER-associated degradation, and ER stress\u2013responsive translation initiation, pointing to a theme of ER protein quality control under stress. Some terms are marked obsolete, but the core signal remains ER protein folding and stress response.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097428","count":2},{"id":"GO:0000002","count":2},{"id":"GO:0034975","count":2},{"id":"GO:0036494","count":2},{"id":"GO:0030433","count":2}]},{"hash":"1426669060281851472","title":"Light-Driven Transcriptional and Circadian Regulation","description":"This cluster centers on light signaling, especially red/far-red phototransduction, and links to circadian rhythm control and transcriptional regulation (including RNA Pol II\u2013mediated transcription) with a note on ubiquitination, suggesting a light-responsive transcriptional program that modulates cell cycle and circadian processes.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034121","count":1},{"id":"GO:0043066","count":1},{"id":"GO:0010018","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0071157","count":1}]},{"hash":"585656170239269648","title":"Developmental Patterning Across Tissues","description":"The listed GO terms cluster around developmental and patterning processes across multiple tissues (e.g., ovarian follicle development, imaginal disc segmentation, intestinal epithelial development) and include regulation of Notch signaling, suggesting a broad role in development rather than a single specific pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016267","count":1},{"id":"GO:0001541","count":1},{"id":"GO:1902367","count":1},{"id":"GO:0007143","count":1},{"id":"GO:0055016","count":1}]},{"hash":"93274555086089263","title":"Unknown","description":"The terms include Cajal body and scaRNA localization (nuclear RNA processing), chaperone-mediated folding/assembly, and immune/inflammatory signals (IL-6 production, isotype switching) plus stress/metal responses. This mix suggests no single coherent function tying the proteins together, so a precise, cohesive label cannot be assigned.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1904871","count":2},{"id":"GO:0051086","count":2},{"id":"GO:0050729","count":2},{"id":"GO:0048291","count":2},{"id":"GO:0090666","count":2}]},{"hash":"798066436441574786","title":"Unknown","description":"The proteins in this cluster do not share a single, cohesive function based on the listed GO terms. The top terms span brain and liver development, nucleotide metabolism (ADP biosynthesis, AMP salvage, purine interconversion), DNA repair, dephosphorylation, and even viral processes, with no shared pathway or interaction evident (no edges or triangles). This broad mix suggests the label Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0046041","count":1},{"id":"GO:0016311","count":1},{"id":"GO:0006172","count":1},{"id":"GO:0016032","count":1}]},{"hash":"396022867791436495","title":"Transmembrane Transport of Ions and Small Molecules","description":"The cluster shows enrichment for several GO terms related to transporting ions and small organic molecules across the plasma membrane (e.g., sodium/potassium ion transport, nitrate and phosphate transport, organic cation transport, sialic acid and ascorbate transport), with a few metabolism terms (e.g., L-ascorbic acid and lactose biosynthesis) that fit the transport/metabolic theme. This points to a common function in membrane transport of diverse substrates.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019852","count":2},{"id":"GO:0070715","count":2},{"id":"GO:0070837","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0071805","count":2}]},{"hash":"184371204181732793","title":"Adrenergic signaling and neurotransmitter secretion","description":"The dominant GO terms point to cellular response to epinephrine and neurotransmitter secretion, with GPCR-mediated signaling. Despite some miscellaneous terms, the clearest shared function among the proteins appears to be adrenergic signaling and synaptic/transmitter release, suggesting a role in neural signaling rather than other processes in this cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071872","count":2},{"id":"GO:0007269","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0035358","count":1},{"id":"GO:1900425","count":1}]},{"hash":"782200839392527792","title":"Choline and phosphatidylethanolamine biosynthesis","description":"This cluster is enriched for GO terms related to choline and ethanolamine metabolism and their use in synthesizing phosphatidylethanolamine, including the CDP-choline pathway. The predominance of lipid biosynthesis terms (choline metabolic process, phosphatidylethanolamine biosynthetic process, ethanolamine metabolic process) supports a phospholipid production theme. While a few terms reflect general stress responses or phosphorylation, the lipid metabolism association best explains the cluster.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019695","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0016310","count":1},{"id":"GO:0006580","count":1},{"id":"GO:0006646","count":1}]},{"hash":"1111830024458353628","title":"Microtubule-based movement and cell division","description":"These terms indicate core involvement of microtubule dynamics in cellular movement, nuclear migration, spindle assembly, and intracellular transport, with additional notes on development and organelle positioning that still reflect cytoskeletal roles. The overarching theme is microtubule-driven processes governing movement and division across different contexts.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030473","count":3},{"id":"GO:0048364","count":3},{"id":"GO:0060404","count":3},{"id":"GO:0000911","count":3},{"id":"GO:0009904","count":3}]},{"hash":"594077458359372808","title":"Wnt Signaling in Development","description":"Based on the top GO terms, the proteins are linked to Wnt signaling components (Wnt signalosome assembly and canonical Wnt pathway) and a range of developmental processes (epithelial proliferation in prostate gland development, ectoderm, oviduct, and root development). Although terms are broad and sparse, the recurring theme centers on Wnt-mediated developmental signaling and related epithelial proliferation. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060769","count":1},{"id":"GO:0048364","count":1},{"id":"GO:1904887","count":1},{"id":"GO:0080034","count":1},{"id":"GO:0007026","count":1}]},{"hash":"1587489308793083787","title":"Cerebellar development and ER calcium homeostasis","description":"The top GO terms point to cerebellar neuron development (Purkinje cell differentiation, granular layer development) and, separately, endoplasmic reticulum calcium ion homeostasis with related regulation of ER stress and protein localization. This combination suggests a small cluster of proteins involved in cerebellar development with a role in ER calcium regulation and stress response, making the label fit the shared themes among the proteins.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021702","count":1},{"id":"GO:1902045","count":1},{"id":"GO:0010523","count":1},{"id":"GO:0032469","count":1},{"id":"GO:0051025","count":1}]},{"hash":"404419453699040301","title":"Translation initiation and ribosome assembly","description":"The top GO terms are centered on translation and initiation, including translation itself, translational initiation, formation of cytoplasmic translation initiation and preinitiation complexes, and ribosome assembly. Although a couple of terms are unrelated (germ cell proliferation, hydrogen peroxide response), the strongest and most frequent signals describe components of the protein synthesis machinery, suggesting this cluster primarily represents translation initiation and ribosome assembly functions.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0045947","count":2},{"id":"GO:0006413","count":2},{"id":"GO:0001732","count":2},{"id":"GO:0002176","count":2}]},{"hash":"1344007675523262748","title":"Muscle calcium signaling and development","description":"This cluster centers on calcium regulation and muscle biology, with terms like regulation of calcium ion concentration, ryanodine receptor\u2013mediated calcium release, skeletal muscle fiber development, and cardiac muscle hypertrophy in response to stress, pointing to calcium-dependent signaling pathways governing muscle growth and contraction. Some terms appear obsolete or less related, but the core theme is calcium-signaling in muscle context.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001915","count":3},{"id":"GO:0051343","count":3},{"id":"GO:0032516","count":3},{"id":"GO:1901901","count":3},{"id":"GO:0060316","count":3}]},{"hash":"1680097620015865963","title":"Cell signaling and cytoskeleton dynamics","description":"This cluster features GO terms tied to signaling pathways (GPCR desensitization, T cell receptor signaling, mast cell cytokine production) and cytoskeletal remodeling (actin cytoskeleton reorganization, axonogenesis), with additional processes like apoptosis and synaptic plasticity regulation. The common thread appears to be proteins involved in coordinating signaling with cytoskeletal changes across different cell types, though the set is somewhat heterogeneous.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":2},{"id":"GO:0007409","count":2},{"id":"GO:0010898","count":2},{"id":"GO:0032092","count":2},{"id":"GO:0050852","count":2}]},{"hash":"1783658836254729782","title":"Ubiquitin-Proteasome Degradation Components","description":"The top GO terms are dominated by ubiquitination and ubiquitin-dependent degradation processes (autoubiquitination, K48-linked ubiquitination, ubiquitin-dependent proteasomal catabolism, ERAD), suggesting the cluster mainly represents components of the ubiquitin-proteasome degradation machinery. A few other terms (chromatin remodeling, peroxisome import, dosage compensation) appear, but they seem secondary to the central degradation theme.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0060816","count":1},{"id":"GO:0038018","count":1},{"id":"GO:0046621","count":1}]},{"hash":"438297635448860764","title":"Unknown","description":"The terms are highly diverse and span membrane transport, ion regulation, metabolism, reproduction, sensory perception, and sporulation, with no clear, common biological process linking the proteins. Therefore there is no coherent theme to assign a specific function label.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042391","count":1},{"id":"GO:0048240","count":1},{"id":"GO:0007605","count":1},{"id":"GO:1902358","count":1},{"id":"GO:0006355","count":1}]},{"hash":"1222479073945780580","title":"Regulation of cell proliferation and differentiation","description":"The GO terms cluster around controlling cell proliferation and differentiation (including regulation of the cell cycle and tissue-specific proliferation in eye morphogenesis). Although one term is tissue-specific (compound eye morphogenesis) and another relates to myeloid progenitor differentiation, the common thread is regulation of cellular proliferation and lineage differentiation, suggesting a cohesive theme of proliferation/differentiation control rather than a single pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000495","count":1},{"id":"GO:0002318","count":1},{"id":"GO:0007050","count":1}]},{"hash":"131501240344353805","title":"Epithelial and Organ Development with Sterol Regulation","description":"The proteins cluster around developmental processes tied to epithelial and glandular tissues (glandular epithelial cell development, ureteric bud and prostate-related development, lymphatic endothelial fate) and general growth, along with sterol/ cholesterol-related responses (cellular response to sterol, cholesterol efflux). This combination suggests a theme of epithelial/organ development intersecting with sterol metabolism.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042551","count":2},{"id":"GO:0060769","count":2},{"id":"GO:0045598","count":2},{"id":"GO:0010875","count":2},{"id":"GO:0060838","count":2}]},{"hash":"1656063400965316735","title":"Mitotic DNA replication and fork dynamics","description":"The top GO terms cluster around mitotic DNA replication processes (elongation, RNA primer removal) and fork dynamics (progression, reversal), with supporting genome maintenance roles such as telomere maintenance and mitochondrial DNA repair, suggesting a cohesive group of replication/maintenance proteins active during mitosis.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:1902983","count":3},{"id":"GO:0006310","count":3},{"id":"GO:1903469","count":3},{"id":"GO:0097046","count":3},{"id":"GO:0044806","count":3}]},{"hash":"2010908214375840815","title":"Inflammation and IL-6 signaling","description":"The cluster\u2019s top GO terms are dominated by immune and inflammatory processes, including positive regulation of inflammatory response and positive regulation of interleukin-6 production, as well as B cell isotype switching to IgG, indicating an immune-activation program. While a few terms touch on nuclear RNA processing and chaperone-related stress responses, the strongest signal centers on inflammation and cytokine signaling, notably IL-6 production, with additional links to oxidative stress and toxin response. Confidence: Medium","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1904871","count":3},{"id":"GO:0051086","count":3},{"id":"GO:0050729","count":3},{"id":"GO:0048291","count":3},{"id":"GO:0090666","count":3}]},{"hash":"1918565349948437159","title":"Inflammation and cytokine signaling","description":"Based on the prominent GO terms, the cluster centers on inflammatory responses and cytokine/chemokine production, including interleukin-8 production, cellular response to interleukin-1, and positive regulation of chemokine production. While a few metabolic terms appear, the immune-related terms collectively define a cohesive theme of inflammation and cytokine signaling, making this label representative. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":1},{"id":"GO:0002532","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0030324","count":1},{"id":"GO:0072606","count":1}]},{"hash":"789859722105589502","title":"Unknown","description":"The top GO terms are scattered across diverse processes (ERAD, RNA methylation, kinase regulation, cell cycle control, development, nuclear transport, ribosome biogenesis, actin nucleation, forebrain development, and lipid signaling). With only 3 proteins and no edges, there isn\u2019t a single cohesive function linking them, so a precise labeled theme isn\u2019t supported.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0061099","count":1},{"id":"GO:1901976","count":1},{"id":"GO:0035264","count":1}]},{"hash":"1526028772101109646","title":"Dopaminergic Neurotransmitter Release and Synaptic Regulation","description":"The dominant GO terms relate to dopamine secretion regulation, calcium-dependent exocytosis of neurotransmitter, and regulation of synaptic plasticity, together with IP3 biosynthesis and sphingolipid biosynthesis, all pointing to neuronal signaling and synaptic transmission. A few terms (ribophagy, B cell differentiation) appear tangential, possibly due to annotation noise or multi-function proteins, but the core theme remains synaptic communication.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014059","count":2},{"id":"GO:1900122","count":2},{"id":"GO:0098746","count":2},{"id":"GO:0034517","count":2},{"id":"GO:0090153","count":2}]},{"hash":"1371722744460287783","title":"Unknown","description":"The GO terms are scattered across mitochondrial energy production and several entirely different developmental and signaling processes, with no single unifying function across the cluster. This makes it hard to assign a coherent, specific label beyond Unknown.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0034553","count":1},{"id":"GO:0006120","count":1},{"id":"GO:0034381","count":1},{"id":"GO:0033034","count":1},{"id":"GO:2000860","count":1}]},{"hash":"1435608322766235375","title":"Choline and phosphatidylethanolamine biosynthesis","description":"The GO terms are dominated by choline and ethanolamine metabolism, plus phosphatidylethanolamine biosynthesis and the CDP-choline pathway, indicating a shared role in phospholipid synthesis and membrane lipid metabolism; ancillary terms likely reflect broader cellular processes.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019695","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0016310","count":1},{"id":"GO:0006580","count":1},{"id":"GO:0006646","count":1}]},{"hash":"1809207504508157260","title":"Immune Signaling and Stress Response","description":"The terms spotlight immune signaling pathways (T cell receptor signaling, mast cell cytokine production) as a core theme, with supporting signs of broader signal modulation (GPCR desensitization) and stress-related responses (hydrogen peroxide response, apoptosis). A few cytoskeletal/axonal terms appear but are less central to the dominant immune signaling theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":1},{"id":"GO:0007409","count":1},{"id":"GO:0010898","count":1},{"id":"GO:0070301","count":1},{"id":"GO:0032092","count":1}]},{"hash":"1303777883908184244","title":"Cell migration and adhesion dynamics","description":"The shared GO terms point to actin cytoskeleton remodeling (lamellipodium assembly, leading edge localization), cell movement (endothelial lumen extension), and cell\u2013cell interactions (epithelial adhesion, lymphocyte aggregation, T cell receptor signaling). Together these reflect a module focused on cell migration, adhesion, and remodeling across immune and endothelial contexts, with some terms touching on broader tissue dynamics.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":2},{"id":"GO:0097498","count":2},{"id":"GO:0071593","count":2},{"id":"GO:0010592","count":2},{"id":"GO:0035264","count":2}]},{"hash":"2195679559686115851","title":"Protein ubiquitination and sumoylation regulators","description":"These proteins show a clear linkage through post-translational modification: sumoylation, ubiquitination, deubiquitination, and autoubiquitination. While other GO terms appear broader (translation, signaling, mitochondria, cardiac regulation), the strongest common theme is regulation of protein modification and turnover.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":2},{"id":"GO:0016579","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0034140","count":1},{"id":"GO:0051865","count":1}]},{"hash":"857931667293207028","title":"Neural development and Purkinje cell maturation","description":"The top GO terms show a clear emphasis on neural differentiation and cerebellar development, with terms like cerebellar Purkinje cell layer maturation, GABAergic neuron differentiation, and radial glia guided migration of Purkinje cells. While there are also terms spanning other tissues (hemopoiesis, enterocyte differentiation, parathyroid hormone secretion, etc.), the strongest and most coherent signal is neural development, especially concerning Purkinje cells and related neural maturation processes.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061026","count":3},{"id":"GO:0060216","count":3},{"id":"GO:0060037","count":3},{"id":"GO:0021691","count":3},{"id":"GO:0097154","count":3}]},{"hash":"820026519624828127","title":"RNA Modification and Telomerase Assembly","description":"The terms converge on snoRNP-mediated RNA modification (pseudouridine synthesis, snoRNA-guided rRNA modification, box H/ACA snoRNP assembly) and telomerase RNA handling (localization to Cajal bodies, holoenzyme assembly, RNA stabilization), with ribosome biogenesis as a related process. This points to a cohesive RNA processing and RNP assembly module, centered on snoRNPs and telomerase.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031120","count":1},{"id":"GO:0000493","count":1},{"id":"GO:1904874","count":1},{"id":"GO:0000454","count":1},{"id":"GO:0042254","count":1}]},{"hash":"1502709005239439410","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0097428","count":2},{"id":"GO:0036494","count":2},{"id":"GO:0034975","count":2},{"id":"GO:0035719","count":2}]},{"hash":"1869384802497581190","title":"Ubiquitination-Driven Cell Cycle Regulation","description":"This cluster\u2019s top GO terms are dominated by ubiquitination and proteasomal degradation (SCF-dependent ubiquitin-dependent protein catabolic process; protein/polyubiquitination), pointing to ubiquitin-proteasome control of protein turnover. Additional terms about regulation of DNA replication initiation and mitotic G1 checkpoint signaling suggest coordination of replication with cell cycle control. A few stress-related terms appear incidental given their low counts. Overall, the theme is ubiquitin-mediated regulation of cell-cycle/DNA replication processes.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060386","count":1},{"id":"GO:1903378","count":1},{"id":"GO:0046685","count":1},{"id":"GO:0031146","count":1},{"id":"GO:1902916","count":1}]},{"hash":"873123249861447086","title":"Developmental Morphogenesis and Signaling","description":"The cluster shows a convergence on developmental processes, with terms like cartilage condensation, axonogenesis, cerebellum morphogenesis, and multicellular growth indicating tissue patterning and morphogenesis, plus cell-cell signaling. A few terms about immune response and apoptotic signaling are present but less central, so the core theme remains developmental morphogenesis and associated signaling pathways.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":2},{"id":"GO:0071226","count":2},{"id":"GO:0031532","count":1},{"id":"GO:0070373","count":1},{"id":"GO:0002250","count":1}]},{"hash":"1665074418498286220","title":"Spliceosome components","description":"The top GO terms are strongly centered on mRNA splicing via the spliceosome and spliceosomal tri-snRNP complex assembly, suggesting these proteins participate in spliceosome formation and splicing. The remaining terms are single-occurrence and reflect broader or unrelated processes, likely incidental. Thus the cluster most coherently reflects spliceosome-related proteins.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":1},{"id":"GO:0000244","count":1},{"id":"GO:0071285","count":1},{"id":"GO:1905206","count":1},{"id":"GO:2001240","count":1}]},{"hash":"1276612334121721789","title":"Ubiquitin-mediated proteostasis","description":"The cluster shows a clear enrichment for ubiquitination-related processes, including protein polyubiquitination, regulation of deubiquitination, and ubiquitin-dependent ERAD, indicating a theme of ubiquitin-driven protein quality control and degradation. The presence of a few unrelated terms (defense response to virus, various morphogenesis and replication initiation terms) likely represents annotation noise rather than a shared functional thread. Overall, the dominant function appears to center on ubiquitin-mediated proteostasis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0007057","count":1},{"id":"GO:1902916","count":1},{"id":"GO:0051607","count":1},{"id":"GO:0060776","count":1}]},{"hash":"494271828233073324","title":"Ubiquitin-Dependent Regulation of T Cell Differentiation","description":"The top GO terms point to ubiquitin-mediated processes (autoubiquitination, ubiquitin-dependent ERAD, ubiquitin-dependent protein catabolic process) and T cell\u2013related regulation (T follicular helper cell differentiation, germinal center formation, T cell proliferation regulation). This combination suggests a coherent theme where ubiquitination governs immune signaling and T cell differentiation, with some additional unrelated terms likely reflecting annotation noise. Confidence reflects a plausible, specific link to ubiquitin-mediated control of T cell biology.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061470","count":2},{"id":"GO:0097070","count":2},{"id":"GO:0002635","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0030433","count":2}]},{"hash":"2146003348325655892","title":"Neutrophil-Mediated Antifungal Response","description":"GO terms strongly point to innate immune activity against fungi, highlighted by neutrophil-mediated killing of fungus, positive regulation of chemokine production, and leukocyte tethering/rolling, together with production of inflammatory mediators. The chitin and carbohydrate catabolic processes likely reflect fungal component processing in this context. Overall, this cluster appears to reflect a neutrophil-driven antifungal inflammatory response.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006032","count":3},{"id":"GO:0005975","count":3},{"id":"GO:0002532","count":3},{"id":"GO:0090197","count":3},{"id":"GO:0042127","count":1}]},{"hash":"173474175674396912","title":"Immune Regulation (T/B cell)","description":"The top GO terms are dominated by immune-related regulatory processes (negative regulation of IgE isotype switching, regulation of T cell proliferation and cytokine production, and B cell tolerance). A few terms (glomerular endothelium development, oocyte growth, sex determination) are less connected, suggesting noise due to the small cluster size. Overall, the strongest signal is immune regulation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048294","count":2},{"id":"GO:0033092","count":1},{"id":"GO:0002725","count":1},{"id":"GO:0033147","count":1},{"id":"GO:0002053","count":1}]},{"hash":"571070695749748061","title":"Broad Small-Molecule Metabolism","description":"The terms are largely metabolic processes involving various substrates (glycine betaine biosynthesis from choline, methanol and methane metabolism, cholesterol metabolism, guanine metabolism, etc.). Though a few terms relate to neuron maturation or membrane potential, the dominant signal is diverse metabolism. This justifies a broad metabolism label rather than a specific pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019285","count":3},{"id":"GO:0015945","count":3},{"id":"GO:0008203","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0046188","count":3}]},{"hash":"731491119625041867","title":"Chemosensory detection and stimulus-driven behavior","description":"The proteins are linked to sensory perception and responses to chemical cues, including bitter taste, CO2 detection, and chemosensory behavior, along with varied stimulus responses (insecticide, caffeine, canavanine) and pheromone-related signals and negative phototaxis. This pattern points to a cohesive function in detecting chemical stimuli and guiding behavior, rather than unrelated metabolic roles. ","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0050913","count":1},{"id":"GO:0003031","count":1},{"id":"GO:0007635","count":1},{"id":"GO:1901354","count":1},{"id":"GO:0016544","count":1}]},{"hash":"1776105735034490979","title":"Unknown","description":"The GO terms are a scattered mix of metabolic processes (androgen metabolism, omega-oxidation, xenobiotic and vitamin D catabolism, methylation) together with tissue-related and stress-related terms (prostate growth, endothelial adhesion, immobilization stress, cesium ion response). There isn\u2019t a single coherent function linking these; with only a few proteins, this cluster cannot be confidently labeled beyond Unknown.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":1},{"id":"GO:0035865","count":1},{"id":"GO:0010430","count":1},{"id":"GO:0060736","count":1},{"id":"GO:0071603","count":1}]},{"hash":"2074094565240097994","title":"Sterol and fatty acid biosynthesis","description":"Most terms point to lipid metabolism, especially sterol biosynthesis (ergosterol, cholesterol via lathosterol) and fatty acid/ether lipid pathways. A few terms are tissue-specific (B cell chemotaxis, CNS myelin maintenance, sebaceous gland differentiation) but do not outweigh the lipid biosynthesis signal. So the cluster is best described as Sterol and fatty acid biosynthesis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035754","count":1},{"id":"GO:0080065","count":1},{"id":"GO:0032286","count":1},{"id":"GO:0046485","count":1},{"id":"GO:0006675","count":1}]},{"hash":"14518426227551640","title":"Viral Entry and Proviral Integration","description":"The GO terms cluster around viral/retroelement processes: viral penetration into host nucleus, DNA integration, proviral latency, RNA-templated DNA biosynthesis, DNA replication/recombination, and RNAi suppression. These imply a shared function in genome integration and host manipulation by a viral or retroelement system, with a few terms like meristem organization and symbiont entry adding possible contextual noise but not undermining the core theme.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006278","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0006310","count":1},{"id":"GO:0039651","count":1},{"id":"GO:0075713","count":1}]},{"hash":"1011694113877499960","title":"Embryonic development and neural differentiation","description":"The top GO terms are dominated by embryonic morphogenesis (forelimb and digit) and regulation of neuron differentiation, indicating a developmental and neural differentiation theme. ER organization terms suggest supporting cellular architecture during development, while a few terms (DNA replication initiation, isotype switching) appear ancillary. Overall, the cluster centers on developmental morphogenesis with neural differentiation as a core facet.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035115","count":1},{"id":"GO:0071787","count":1},{"id":"GO:0042733","count":1},{"id":"GO:0050803","count":1},{"id":"GO:0032330","count":1}]},{"hash":"402847575342274572","title":"Unknown","description":"The top GO terms are highly heterogeneous, spanning pigment biosynthesis, morphogenesis in a slime mold, plant hormone responses, transport processes, nutrient absorption, and nodulation, with no clear, shared biological theme tying the proteins together. With only three proteins and no network connections, there is insufficient evidence for a cohesive function, so an Unknown label is appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006727","count":1},{"id":"GO:0031288","count":1},{"id":"GO:0055099","count":1},{"id":"GO:0003333","count":1},{"id":"GO:0071366","count":1}]},{"hash":"1808417438321630111","title":"Larval cuticle development and face morphogenesis","description":"This cluster's top GO terms indicate two related developmental processes\u2014larval chitin-based cuticle development and face morphogenesis\u2014suggesting proteins here participate in morphological development, possibly in insects. The limited term counts mean the label is a best-effort, high-level description rather than a detailed functional annotation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0060325","count":1}]},{"hash":"403386971174786825","title":"Mitochondrial membrane transport and dynamics","description":"The top GO terms cluster around transport of metabolites and ions across mitochondrial membranes (ATP, NAD, thiamine pyrophosphate, deoxynucleotides, phosphate, magnesium) and include processes regulating membrane permeability and fission, as well as apoptotic mitochondrial changes, indicating a cohesive theme of mitochondrial membrane transport and remodeling.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008637","count":1},{"id":"GO:0030974","count":1},{"id":"GO:0000002","count":1},{"id":"GO:0090149","count":1},{"id":"GO:0030302","count":1}]}]