{"hash":"1932309127094915759","title":"Calcium-Regulated Muscle Contraction","description":"This cluster centers on calcium handling linked to muscle contraction. The top GO terms emphasize regulation of sequestered calcium release and activity of ryanodine-sensitive channels, along with skeletal and cardiac contraction regulation and sarcomere organization. Additional terms about denervation-driven muscle adaptation and caffeine-induced calcium signaling support a unifying theme of calcium-dependent control of muscle contraction, with some ER-associated processing that supports proper protein function in this pathway.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"members":[{"accession":"XP_045403034.1","go_terms":["GO:2001238","GO:0018401","GO:0045454","GO:0006621","GO:0051258","GO:0002027","GO:0007029","GO:0071313","GO:0060306","GO:1901017","GO:0014894","GO:0060315","GO:0045214","GO:0051208","GO:0010881","GO:0010649","GO:0060048","GO:0014809"]},{"accession":"XP_045411403.1","go_terms":["GO:0006071","GO:0034478","GO:0030643","GO:0010442"]},{"accession":"XP_045381354.1","go_terms":["GO:1902043","GO:0034115","GO:0042552","GO:0050861","GO:0007605","GO:0045056","GO:0070830","GO:0090038","GO:0002337","GO:0035208","GO:0021762","GO:0001766","GO:0048172","GO:0048169","GO:0061028","GO:0070941"]},{"accession":"XP_045386034.1","go_terms":["GO:0017000","GO:0019380","GO:0009102","GO:0009820","GO:0009636","GO:0098869","GO:1901601","GO:0046839","GO:0019740","GO:0046272","GO:1905344","GO:0010223","GO:0019391","GO:0055114","GO:2000124","GO:0042619","GO:0097755","GO:0006212","GO:0019260","GO:0019433","GO:0042952","GO:0009086","GO:0009234","GO:1902348","GO:1990577","GO:0015996","GO:0052651","GO:0006660","GO:0019373"]},{"accession":"XP_045388265.1","go_terms":["GO:0007219","GO:0034205","GO:0006509","GO:0007220","GO:0031293","GO:0060465"]},{"accession":"XP_045408042.1","go_terms":["GO:0015699","GO:0006849","GO:0015700","GO:0043251"]},{"accession":"XP_045394351.1","go_terms":["GO:0002037","GO:0006888","GO:0008631","GO:0010917"]}],"graph":[["XP_045394351.1","XP_045381354.1",0.802],["XP_045408042.1","XP_045388265.1",0.603],["XP_045411403.1","XP_045381354.1",0.604],["XP_045381354.1","XP_045386034.1",0.926],["XP_045381354.1","XP_045388265.1",0.857],["XP_045381354.1","XP_045403034.1",0.832]],"all_go_terms":{"GO:0014809":1,"GO:0060315":1,"GO:0071313":1,"GO:0045214":1,"GO:0045454":1,"GO:0006621":1,"GO:0014894":1,"GO:0018401":1,"GO:0051258":1,"GO:0010881":1,"GO:2001238":1,"GO:0060306":1,"GO:1901017":1,"GO:0060048":1,"GO:0051208":1,"GO:0002027":1,"GO:0007029":1,"GO:0010649":1,"GO:0006071":1,"GO:0034478":1,"GO:0010442":1,"GO:0030643":1,"GO:0090038":1,"GO:1902043":1,"GO:0045056":1,"GO:0001766":1,"GO:0007605":1,"GO:0070830":1,"GO:0035208":1,"GO:0002337":1,"GO:0048169":1,"GO:0048172":1,"GO:0070941":1,"GO:0050861":1,"GO:0021762":1,"GO:0061028":1,"GO:0042552":1,"GO:0034115":1,"GO:1901601":1,"GO:0006212":1,"GO:2000124":1,"GO:0052651":1,"GO:0042952":1,"GO:0017000":1,"GO:0009636":1,"GO:0009102":1,"GO:0046839":1,"GO:0019391":1,"GO:0019380":1,"GO:0046272":1,"GO:0019433":1,"GO:0006660":1,"GO:0055114":1,"GO:1902348":1,"GO:0019373":1,"GO:0009086":1,"GO:0010223":1,"GO:0098869":1,"GO:1905344":1,"GO:0009234":1,"GO:1990577":1,"GO:0015996":1,"GO:0009820":1,"GO:0097755":1,"GO:0019740":1,"GO:0042619":1,"GO:0019260":1,"GO:0060465":1,"GO:0007220":1,"GO:0034205":1,"GO:0031293":1,"GO:0006509":1,"GO:0007219":1,"GO:0015700":1,"GO:0015699":1,"GO:0006849":1,"GO:0043251":1,"GO:0008631":1,"GO:0006888":1,"GO:0010917":1,"GO:0002037":1},"recipe_readded":[]}