{"hash":"2226929474634460074","title":"Retinoid and Prostaglandin Metabolism in Kidney and Retina","description":"The cluster\u2019s top GO terms center on retinoid metabolism (retinol/retinal), retinal metabolic processes, and prostaglandin biosynthesis, alongside vitamin C biosynthesis and redox-related response, all pointing to vitamin A\u2013 and lipid mediator\u2013related metabolism. Several terms also reflect kidney/urinary development (renal system and inner medullary collecting duct development), suggesting tissue-specific regulatory roles in kidney and eye structures. This combination supports a focused theme on retinoid and prostaglandin pathways in kidney and retinal development, with redox signaling as a contributing context.","confidence":"High","size":17,"edges":94,"triangles":249,"max_degree":16,"top_function":null,"members":[{"accession":"XP_055352165.1","go_terms":["GO:0007494","GO:0048566","GO:0031016","GO:0031076","GO:0009450","GO:0060324","GO:0021983","GO:0021915","GO:0042572","GO:0042574","GO:0048384","GO:0021768","GO:0035799","GO:0014032","GO:0050885","GO:0009258","GO:0001568","GO:0006540","GO:0042904","GO:0043584","GO:0019545","GO:0019544","GO:1901023","GO:0009954","GO:0019285","GO:0007584","GO:0060013","GO:0070384","GO:0060166","GO:0009447","GO:0003007","GO:0035115","GO:0051591","GO:0010133","GO:0006678","GO:0042472","GO:0009952","GO:0002072","GO:0019413","GO:0036293","GO:0055129","GO:0015976","GO:0032180","GO:0048738","GO:0071300","GO:0006537","GO:0030900","GO:0030902","GO:0009855","GO:0001936","GO:0006068","GO:0006069"]},{"accession":"XP_055328671.1","go_terms":["GO:0006099","GO:0009060","GO:0022904","GO:0044780","GO:0019516","GO:0006113","GO:0015948","GO:0071973","GO:0019684","GO:0055114"]},{"accession":"XP_055332645.1","go_terms":["GO:0035229","GO:0044598","GO:0071799","GO:0001894","GO:0009414","GO:0060135","GO:0042572","GO:0042574","GO:0006750","GO:0019853","GO:0071395","GO:0044597","GO:0071805","GO:0042840","GO:0003091","GO:0042843","GO:0042448","GO:0031098","GO:0043066","GO:0042821","GO:0061370","GO:0051897","GO:0006700","GO:0006707","GO:0046427","GO:0018931","GO:0048661","GO:0007586","GO:0070301","GO:0046370","GO:2000353","GO:0001516","GO:0042415","GO:0019568","GO:0016488","GO:0048385","GO:0070485","GO:0072001","GO:0008584","GO:0072061","GO:0055114","GO:0097238","GO:0071277","GO:0097066","GO:1900053","GO:0030573","GO:0035809","GO:1901653","GO:0006061","GO:0006699","GO:2000224","GO:0071276","GO:0008209"]},{"accession":"XP_055333036.1","go_terms":["GO:0035229","GO:0044598","GO:0071799","GO:0001894","GO:0009414","GO:0060135","GO:0042572","GO:0042574","GO:0006750","GO:0019853","GO:0071395","GO:0044597","GO:0071805","GO:0042840","GO:0003091","GO:0042843","GO:0042448","GO:0031098","GO:0043066","GO:0042821","GO:0061370","GO:0051897","GO:0006700","GO:0006707","GO:0046427","GO:0018931","GO:0048661","GO:0007586","GO:0070301","GO:0046370","GO:2000353","GO:0001516","GO:0042415","GO:0019568","GO:0016488","GO:0048385","GO:0070485","GO:0072001","GO:0008584","GO:0072061","GO:0055114","GO:0097238","GO:0071277","GO:0097066","GO:1900053","GO:0030573","GO:0035809","GO:1901653","GO:0006061","GO:0006699","GO:2000224","GO:0071276","GO:0008209"]},{"accession":"XP_055334885.1","go_terms":["GO:0035229","GO:0044598","GO:0071799","GO:0001894","GO:0009414","GO:0060135","GO:0042572","GO:0042574","GO:0006750","GO:0019853","GO:0071395","GO:0044597","GO:0071805","GO:0042840","GO:0003091","GO:0042843","GO:0042448","GO:0031098","GO:0043066","GO:0042821","GO:0061370","GO:0051897","GO:0006700","GO:0006707","GO:0046427","GO:0018931","GO:0048661","GO:0007586","GO:0070301","GO:0046370","GO:2000353","GO:0001516","GO:0042415","GO:0019568","GO:0016488","GO:0048385","GO:0070485","GO:0072001","GO:0008584","GO:0072061","GO:0055114","GO:0097238","GO:0071277","GO:0097066","GO:1900053","GO:0030573","GO:0035809","GO:1901653","GO:0006061","GO:0006699","GO:2000224","GO:0071276","GO:0008209"]},{"accession":"XP_055335831.1","go_terms":["GO:0051726","GO:1902476","GO:0060315","GO:1902000","GO:0010880","GO:0051881","GO:0045669","GO:0070527","GO:0009072","GO:0019852","GO:0009407","GO:0042594","GO:0014810","GO:0060316","GO:0006289","GO:0098869","GO:0010731","GO:0006749","GO:0045454","GO:0071243","GO:0010043","GO:0006808","GO:0042994","GO:0010044","GO:1901687","GO:0009734","GO:0042178","GO:0043651","GO:0009635","GO:0070458","GO:0002182","GO:0007608","GO:0018916","GO:0055119","GO:0043517","GO:0071285","GO:2000774","GO:0060510","GO:2001237","GO:0043508","GO:0033591","GO:0048147","GO:0032930","GO:0032869","GO:0001516","GO:0051771","GO:0035726","GO:0043200","GO:0032355","GO:0040008","GO:0002674","GO:0009636","GO:0032691","GO:0070664","GO:2000429","GO:0043124","GO:0007417","GO:1904706","GO:0032720","GO:0010804","GO:0031100","GO:0071385","GO:2000469","GO:2000255","GO:0045471","GO:0014003","GO:0071364","GO:0071638","GO:0035732","GO:0071460","GO:0071672","GO:0070373"]},{"accession":"XP_055336952.1","go_terms":["GO:0046039","GO:0044209","GO:0006270","GO:0046939","GO:0015951","GO:0001889","GO:0046041","GO:0046940","GO:0006172","GO:0007420","GO:0046705"]},{"accession":"XP_055336984.1","go_terms":["GO:0003147","GO:0009263","GO:0098869","GO:0071473","GO:0030416","GO:0080058","GO:1903026","GO:0045454","GO:2000651","GO:0034599","GO:0055114"]},{"accession":"XP_055339516.1","go_terms":["GO:0035229","GO:0044598","GO:0071799","GO:0001894","GO:0009414","GO:0060135","GO:0042572","GO:0042574","GO:0006750","GO:0019853","GO:0071395","GO:0044597","GO:0071805","GO:0042840","GO:0003091","GO:0042843","GO:0042448","GO:0031098","GO:0043066","GO:0042821","GO:0061370","GO:0051897","GO:0006700","GO:0006707","GO:0046427","GO:0018931","GO:0048661","GO:0007586","GO:0070301","GO:0046370","GO:2000353","GO:0001516","GO:0042415","GO:0019568","GO:0016488","GO:0048385","GO:0070485","GO:0072001","GO:0008584","GO:0072061","GO:0055114","GO:0097238","GO:0071277","GO:0097066","GO:1900053","GO:0030573","GO:0035809","GO:1901653","GO:0006061","GO:0006699","GO:2000224","GO:0071276","GO:0008209"]},{"accession":"XP_055341712.1","go_terms":["GO:0017004","GO:0098869","GO:0045454","GO:0042158","GO:0055114","GO:0008584","GO:0042744","GO:0007252","GO:0034101","GO:0018171","GO:0070301","GO:2000255","GO:0032872","GO:0007283","GO:0030416","GO:0042345","GO:0042267","GO:0019471","GO:0022417","GO:0019430","GO:0030198"]},{"accession":"XP_055342032.1","go_terms":["GO:2001213","GO:0007595","GO:0006124","GO:0009399","GO:0006814","GO:0045602","GO:1900747","GO:0009115","GO:0010124","GO:0042773"]},{"accession":"XP_055345610.1","go_terms":["GO:0017004","GO:0098869","GO:0045454","GO:0042158","GO:0055114","GO:0008584","GO:0042744","GO:0007252","GO:0034101","GO:0018171","GO:0070301","GO:2000255","GO:0032872","GO:0007283","GO:0030416","GO:0042345","GO:0042267","GO:0019471","GO:0022417","GO:0019430","GO:0030198"]},{"accession":"XP_055349419.1","go_terms":["GO:2001213","GO:0007595","GO:0006124","GO:0009399","GO:0006814","GO:0045602","GO:1900747","GO:0009115","GO:0010124","GO:0042773"]},{"accession":"XP_055352225.1","go_terms":["GO:0042776","GO:0006122"]},{"accession":"XP_055352456.1","go_terms":["GO:0035229","GO:0044598","GO:0071799","GO:0001894","GO:0009414","GO:0060135","GO:0042572","GO:0042574","GO:0006750","GO:0019853","GO:0071395","GO:0044597","GO:0071805","GO:0042840","GO:0003091","GO:0042843","GO:0042448","GO:0031098","GO:0043066","GO:0042821","GO:0061370","GO:0051897","GO:0006700","GO:0006707","GO:0046427","GO:0018931","GO:0048661","GO:0007586","GO:0070301","GO:0046370","GO:2000353","GO:0001516","GO:0042415","GO:0019568","GO:0016488","GO:0048385","GO:0070485","GO:0072001","GO:0008584","GO:0072061","GO:0055114","GO:0097238","GO:0071277","GO:0097066","GO:1900053","GO:0030573","GO:0035809","GO:1901653","GO:0006061","GO:0006699","GO:2000224","GO:0071276","GO:0008209"]},{"accession":"XP_055356979.1","go_terms":["GO:0046381","GO:0042203","GO:1902600","GO:0010196","GO:0046232","GO:0015979","GO:0055114","GO:0006122"]},{"accession":"XP_055345300.1","go_terms":["GO:0035229","GO:0044598","GO:0071799","GO:0001894","GO:0009414","GO:0060135","GO:0042572","GO:0042574","GO:0006750","GO:0019853","GO:0071395","GO:0044597","GO:0071805","GO:0042840","GO:0003091","GO:0042843","GO:0042448","GO:0031098","GO:0043066","GO:0042821","GO:0061370","GO:0051897","GO:0006700","GO:0006707","GO:0046427","GO:0018931","GO:0048661","GO:0007586","GO:0070301","GO:0046370","GO:2000353","GO:0001516","GO:0042415","GO:0019568","GO:0016488","GO:0048385","GO:0070485","GO:0072001","GO:0008584","GO:0072061","GO:0055114","GO:0097238","GO:0071277","GO:0097066","GO:1900053","GO:0030573","GO:0035809","GO:1901653","GO:0006061","GO:0006699","GO:2000224","GO:0071276","GO:0008209"]}],"graph":[["XP_055341712.1","XP_055328671.1",0.945],["XP_055341712.1","XP_055335831.1",0.988],["XP_055341712.1","XP_055336952.1",0.978],["XP_055341712.1","XP_055336984.1",0.989],["XP_055341712.1","XP_055345300.1",0.53],["XP_055341712.1","XP_055345610.1",0.912],["XP_055341712.1","XP_055342032.1",0.97],["XP_055341712.1","XP_055356979.1",0.94],["XP_055341712.1","XP_055352165.1",0.511],["XP_055341712.1","XP_055352225.1",0.887],["XP_055341712.1","XP_055352456.1",0.797],["XP_055341712.1","XP_055349419.1",0.948],["XP_055342032.1","XP_055328671.1",0.967],["XP_055342032.1","XP_055333036.1",0.858],["XP_055342032.1","XP_055334885.1",0.911],["XP_055342032.1","XP_055335831.1",0.985],["XP_055342032.1","XP_055336952.1",0.968],["XP_055342032.1","XP_055336984.1",0.981],["XP_055342032.1","XP_055339516.1",0.953],["XP_055342032.1","XP_055345610.1",0.964],["XP_055342032.1","XP_055356979.1",0.979],["XP_055342032.1","XP_055352225.1",0.955],["XP_055342032.1","XP_055349419.1",0.971],["XP_055339516.1","XP_055332645.1",0.96],["XP_055339516.1","XP_055333036.1",0.956],["XP_055339516.1","XP_055334885.1",0.961],["XP_055339516.1","XP_055335831.1",0.89],["XP_055339516.1","XP_055336952.1",0.921],["XP_055339516.1","XP_055336984.1",0.964],["XP_055339516.1","XP_055345300.1",0.944],["XP_055339516.1","XP_055352165.1",0.942],["XP_055339516.1","XP_055352456.1",0.958],["XP_055339516.1","XP_055349419.1",0.983],["XP_055352225.1","XP_055328671.1",0.668],["XP_055352225.1","XP_055335831.1",0.991],["XP_055352225.1","XP_055336952.1",0.955],["XP_055352225.1","XP_055336984.1",0.982],["XP_055352225.1","XP_055345610.1",0.822],["XP_055352225.1","XP_055349419.1",0.975],["XP_055352225.1","XP_055356979.1",0.796],["XP_055335831.1","XP_055328671.1",0.972],["XP_055335831.1","XP_055334885.1",0.647],["XP_055335831.1","XP_055336952.1",0.984],["XP_055335831.1","XP_055336984.1",0.979],["XP_055335831.1","XP_055345300.1",0.938],["XP_055335831.1","XP_055345610.1",0.978],["XP_055335831.1","XP_055356979.1",0.979],["XP_055335831.1","XP_055349419.1",0.982],["XP_055345610.1","XP_055328671.1",0.973],["XP_055345610.1","XP_055336952.1",0.984],["XP_055345610.1","XP_055336984.1",0.977],["XP_055345610.1","XP_055345300.1",0.895],["XP_055345610.1","XP_055349419.1",0.986],["XP_055345610.1","XP_055356979.1",0.985],["XP_055345300.1","XP_055332645.1",0.96],["XP_055345300.1","XP_055333036.1",0.951],["XP_055345300.1","XP_055334885.1",0.94],["XP_055345300.1","XP_055336952.1",0.947],["XP_055345300.1","XP_055336984.1",0.946],["XP_055345300.1","XP_055349419.1",0.875],["XP_055345300.1","XP_055352165.1",0.928],["XP_055345300.1","XP_055352456.1",0.947],["XP_055345300.1","XP_055356979.1",0.921],["XP_055352456.1","XP_055328671.1",0.521],["XP_055352456.1","XP_055332645.1",0.956],["XP_055352456.1","XP_055333036.1",0.948],["XP_055352456.1","XP_055334885.1",0.956],["XP_055352456.1","XP_055336984.1",0.825],["XP_055352456.1","XP_055352165.1",0.92],["XP_055352456.1","XP_055356979.1",0.766],["XP_055336984.1","XP_055328671.1",0.985],["XP_055336984.1","XP_055332645.1",0.947],["XP_055336984.1","XP_055333036.1",0.895],["XP_055336984.1","XP_055334885.1",0.95],["XP_055336984.1","XP_055336952.1",0.981],["XP_055336984.1","XP_055349419.1",0.98],["XP_055336984.1","XP_055352165.1",0.902],["XP_055336984.1","XP_055356979.1",0.983],["XP_055356979.1","XP_055328671.1",0.965],["XP_055356979.1","XP_055336952.1",0.982],["XP_055356979.1","XP_055349419.1",0.975],["XP_055333036.1","XP_055336952.1",0.505],["XP_055333036.1","XP_055334885.1",0.947],["XP_055333036.1","XP_055332645.1",0.966],["XP_055333036.1","XP_055349419.1",0.852],["XP_055333036.1","XP_055352165.1",0.923],["XP_055336952.1","XP_055328671.1",0.985],["XP_055336952.1","XP_055334885.1",0.772],["XP_055336952.1","XP_055349419.1",0.976],["XP_055352165.1","XP_055332645.1",0.937],["XP_055352165.1","XP_055334885.1",0.919],["XP_055332645.1","XP_055334885.1",0.95],["XP_055332645.1","XP_055349419.1",0.859],["XP_055328671.1","XP_055349419.1",0.983]],"all_go_terms":{"GO:0042574":7,"GO:0006540":1,"GO:0019413":1,"GO:0009952":1,"GO:0006068":1,"GO:0048738":1,"GO:0051591":1,"GO:0019545":1,"GO:0009855":1,"GO:0021915":1,"GO:0043584":1,"GO:0060166":1,"GO:0001936":1,"GO:0055129":1,"GO:0032180":1,"GO:0006678":1,"GO:0031016":1,"GO:0042904":1,"GO:0036293":1,"GO:0060324":1,"GO:0006069":1,"GO:0019544":1,"GO:0042572":7,"GO:0070384":1,"GO:0002072":1,"GO:0035799":1,"GO:0060013":1,"GO:0042472":1,"GO:0001568":1,"GO:0007494":1,"GO:0030900":1,"GO:0050885":1,"GO:0071300":1,"GO:0009258":1,"GO:0035115":1,"GO:0021768":1,"GO:1901023":1,"GO:0010133":1,"GO:0007584":1,"GO:0019285":1,"GO:0014032":1,"GO:0030902":1,"GO:0003007":1,"GO:0048566":1,"GO:0009450":1,"GO:0009954":1,"GO:0015976":1,"GO:0048384":1,"GO:0031076":1,"GO:0021983":1,"GO:0009447":1,"GO:0006537":1,"GO:0019516":1,"GO:0006099":1,"GO:0006113":1,"GO:0019684":1,"GO:0055114":11,"GO:0015948":1,"GO:0044780":1,"GO:0009060":1,"GO:0022904":1,"GO:0071973":1,"GO:0072061":6,"GO:0097066":6,"GO:0019853":6,"GO:0072001":6,"GO:0008584":8,"GO:0048661":6,"GO:0006061":6,"GO:0044597":6,"GO:0019568":6,"GO:0018931":6,"GO:0060135":6,"GO:0031098":6,"GO:0006700":6,"GO:2000353":6,"GO:0035809":6,"GO:0035229":6,"GO:0042415":6,"GO:0003091":6,"GO:0070485":6,"GO:0046427":6,"GO:0071799":6,"GO:0070301":8,"GO:2000224":6,"GO:0048385":6,"GO:0061370":6,"GO:0042843":6,"GO:0043066":6,"GO:0071277":6,"GO:1901653":6,"GO:0097238":6,"GO:0044598":6,"GO:0030573":6,"GO:1900053":6,"GO:0071276":6,"GO:0006699":6,"GO:0006750":6,"GO:0007586":6,"GO:0016488":6,"GO:0042821":6,"GO:0051897":6,"GO:0008209":6,"GO:0042840":6,"GO:0009414":6,"GO:0001516":7,"GO:0042448":6,"GO:0071395":6,"GO:0071805":6,"GO:0006707":6,"GO:0001894":6,"GO:0046370":6,"GO:1904706":1,"GO:0045669":1,"GO:0014810":1,"GO:0043508":1,"GO:0071638":1,"GO:0032930":1,"GO:0045454":4,"GO:1901687":1,"GO:0009734":1,"GO:0048147":1,"GO:0010804":1,"GO:0060316":1,"GO:0033591":1,"GO:2000429":1,"GO:0070373":1,"GO:0019852":1,"GO:0006749":1,"GO:0031100":1,"GO:0032355":1,"GO:0071672":1,"GO:0009636":1,"GO:0071385":1,"GO:2000774":1,"GO:0007417":1,"GO:0071460":1,"GO:0051726":1,"GO:0010731":1,"GO:0032691":1,"GO:0009072":1,"GO:1902476":1,"GO:0002674":1,"GO:2000255":3,"GO:0035732":1,"GO:0071364":1,"GO:0032720":1,"GO:0032869":1,"GO:0070458":1,"GO:0060315":1,"GO:0010044":1,"GO:0006289":1,"GO:0042594":1,"GO:0043517":1,"GO:0010880":1,"GO:0071243":1,"GO:0007608":1,"GO:0051771":1,"GO:0040008":1,"GO:0002182":1,"GO:0035726":1,"GO:0098869":4,"GO:0014003":1,"GO:0043124":1,"GO:0043200":1,"GO:1902000":1,"GO:0006808":1,"GO:0071285":1,"GO:0070664":1,"GO:0042178":1,"GO:0043651":1,"GO:2000469":1,"GO:0009635":1,"GO:0045471":1,"GO:0010043":1,"GO:0042994":1,"GO:2001237":1,"GO:0009407":1,"GO:0051881":1,"GO:0055119":1,"GO:0060510":1,"GO:0070527":1,"GO:0018916":1,"GO:0006270":1,"GO:0046705":1,"GO:0046039":1,"GO:0046939":1,"GO:0006172":1,"GO:0044209":1,"GO:0007420":1,"GO:0015951":1,"GO:0046940":1,"GO:0046041":1,"GO:0001889":1,"GO:0030416":3,"GO:1903026":1,"GO:2000651":1,"GO:0071473":1,"GO:0009263":1,"GO:0003147":1,"GO:0080058":1,"GO:0034599":1,"GO:0034101":2,"GO:0007283":2,"GO:0032872":2,"GO:0022417":2,"GO:0042345":2,"GO:0042267":2,"GO:0042158":2,"GO:0019471":2,"GO:0017004":2,"GO:0007252":2,"GO:0042744":2,"GO:0018171":2,"GO:0030198":2,"GO:0019430":2,"GO:1900747":2,"GO:0010124":2,"GO:0042773":2,"GO:0009115":2,"GO:0006814":2,"GO:0006124":2,"GO:2001213":2,"GO:0045602":2,"GO:0007595":2,"GO:0009399":2,"GO:0006122":2,"GO:0042776":1,"GO:0010196":1,"GO:0046381":1,"GO:0015979":1,"GO:0046232":1,"GO:1902600":1,"GO:0042203":1},"recipe_readded":[]}