{"hash":"127302133718382761","title":"Folate and One-Carbon Metabolism","description":"The GO terms cluster around dihydrofolate/tetrahydrofolate biosynthesis, folate metabolism, one-carbon metabolism, glycine synthesis, dTMP biosynthesis, and methylation. These collectively define the folate/one-carbon metabolic pathway that provides methyl groups for nucleotide synthesis and methylation reactions. Some terms like axon regeneration and superoxide regulation may be ancillary or context-specific rather than core to this cluster. Overall, the dominant theme is folate-driven one-carbon metabolism and methylation.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"members":[{"accession":"XP_042203534.1","go_terms":["GO:0006730","GO:0000083","GO:0051000","GO:0046655","GO:0046654","GO:0006545","GO:0032259","GO:0006729","GO:0031103","GO:0046105","GO:0055114","GO:2000121","GO:0006231","GO:0031427","GO:0046452","GO:0046677"]},{"accession":"XP_042203857.1","go_terms":["GO:0006909","GO:0030240","GO:0010628","GO:0021762","GO:0034314","GO:0051654","GO:0002121","GO:0042766","GO:0043503","GO:0071963","GO:0009825","GO:0006348","GO:0000147","GO:0000001","GO:0043486","GO:0000281","GO:0016344","GO:0030476","GO:1904623","GO:0048741","GO:0032508","GO:0051017","GO:0045214","GO:0051666","GO:0030041","GO:0001895","GO:0030100","GO:0090131","GO:0051592","GO:0000011","GO:0000916","GO:0001300","GO:0043982","GO:0043983","GO:0043981","GO:0070527","GO:1903475","GO:0098974"]},{"accession":"XP_042243116.1","go_terms":[]},{"accession":"XP_042206716.1","go_terms":[]}],"graph":[["XP_042203534.1","XP_042203857.1",0.665]],"all_go_terms":{"GO:0046452":1,"GO:0046654":1,"GO:0006545":1,"GO:0046655":1,"GO:0006730":1,"GO:0006231":1,"GO:2000121":1,"GO:0032259":1,"GO:0031103":1,"GO:0006729":1,"GO:0046105":1,"GO:0000083":1,"GO:0031427":1,"GO:0046677":1,"GO:0055114":1,"GO:0051000":1,"GO:0030476":1,"GO:0002121":1,"GO:0042766":1,"GO:0032508":1,"GO:0045214":1,"GO:0043982":1,"GO:0043503":1,"GO:0051666":1,"GO:0030041":1,"GO:0098974":1,"GO:0000011":1,"GO:1903475":1,"GO:0010628":1,"GO:0030100":1,"GO:0043981":1,"GO:0006909":1,"GO:0030240":1,"GO:0001300":1,"GO:0051654":1,"GO:0043983":1,"GO:0043486":1,"GO:0071963":1,"GO:0021762":1,"GO:0000001":1,"GO:0051592":1,"GO:0048741":1,"GO:0016344":1,"GO:0001895":1,"GO:0000916":1,"GO:0090131":1,"GO:0000147":1,"GO:0009825":1,"GO:1904623":1,"GO:0034314":1,"GO:0070527":1,"GO:0006348":1,"GO:0000281":1,"GO:0051017":1},"recipe_readded":["XP_042240899.1","XP_042214577.1","XP_042243019.1","XP_042242935.1","XP_042232010.1","XP_042234845.1","XP_042227956.1","XP_042226638.1","XP_042208403.1","XP_042227006.1","XP_042235615.1","XP_042233156.1","XP_042210786.1","XP_042233915.1","XP_042223280.1","XP_042222292.1","XP_042214520.1","XP_042238578.1","XP_042236310.1","XP_042220974.1"]}