[{"hash":"1295983024143776215","title":"DNA-Templated Transcription Regulation and Development Signaling","description":"The top GO terms show a strong emphasis on DNA-templated transcription and its regulation, suggesting a core function in transcription control. Additional terms point to signaling and development in neural and immune contexts (TLR/MyD88 signaling, necroptosis via ripoptosome, hippocampus development, peripheral nervous system axonogenesis). Some terms (antibiotic biosynthesis, protein repair) are less clearly connected but may reflect broader metabolic or maintenance roles in these proteins. Overall, the cluster appears centered on transcription regulation with linked signaling and developmental processes.","confidence":"Medium","size":29,"edges":57,"triangles":29,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0006355","count":3},{"id":"GO:0017000","count":3},{"id":"GO:1990108","count":2}]},{"hash":"341680860392125914","title":"Xenobiotic response and fatty acid metabolism","description":"The cluster is dominated by terms related to cellular response to xenobiotic stimulus and fatty acid metabolism, including long-chain/very long-chain fatty acid metabolism and fatty acid import, suggesting coordinated detoxification signaling and lipid substrate processing. Additional ties to stress signaling (calcium, nitric oxide) and metabolic remodeling (proteolysis, catabolic pathways) reinforce a theme of handling external compounds alongside lipid metabolism. Confidence: High","confidence":"","size":29,"edges":62,"triangles":54,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":11},{"id":"GO:0006508","count":11},{"id":"GO:0071732","count":11},{"id":"GO:0071277","count":11},{"id":"GO:0050667","count":11}]},{"hash":"1805075448716057619","title":"Nutrient and xenobiotic transporter cluster","description":"This cluster is characterized by multiple transmembrane transport terms, including L-ascorbic acid and dehydroascorbic acid transport, D-xylose and glucose transport, sodium-dependent organic cation transport, and glucose import in response to insulin. The presence of xenobiotic transport and osmotic stress response suggests a membrane transporter-focused group involved in nutrient uptake and compound export, with some epithelial maintenance context. Overall, the common theme is transporter activity for sugars, vitamins, and xenobiotics.","confidence":"Medium","size":29,"edges":30,"triangles":11,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0019852","count":6},{"id":"GO:0042908","count":6},{"id":"GO:0070837","count":6},{"id":"GO:0015753","count":6},{"id":"GO:0006970","count":6}]},{"hash":"802611945380875971","title":"Insect body morphogenesis and cuticle development","description":"In this cluster, the strongest GO signals are body morphogenesis and chitin-based cuticle development, which together point to developmental processes shaping the insect body and its protective exoskeleton. The presence of glycogen-related terms and other miscellaneous annotations may reflect metabolic needs during development or annotation noise, but the core theme appears to be developmentally driven cuticle formation. Confidence: Medium","confidence":"","size":29,"edges":17,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010171","count":2},{"id":"GO:0040003","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0061723","count":1},{"id":"GO:0045819","count":1}]},{"hash":"459857770180783898","title":"Chitin Metabolism and Cuticle Formation","description":"This cluster is dominated by GO terms directly tied to chitin-based cuticle development in larvae and chitin catabolic processes, indicating proteins involved in chitin synthesis/degradation and cuticle formation. Additional terms like carbohydrate metabolic process and xenobiotic response align with energy and detoxification needs during development, while inflammatory mediator production hints at immune-related activity in cuticle-associated tissues. Overall, the core theme centers on chitin metabolism and cuticle development.","confidence":"High","size":29,"edges":25,"triangles":41,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":5},{"id":"GO:0042493","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0006032","count":2}]},{"hash":"233402763162380392","title":"Metabolism and Ion Transport Cluster","description":"This cluster mixes diverse metabolic processes (carbohydrate metabolism, L-serine biosynthesis, stilbene catabolism, lipopolysaccharide biosynthesis) with ion handling (zinc and cadmium transport, calcium homeostasis) and dephosphorylation activity, suggesting proteins involved in general metabolism and ion regulation rather than a single pathway. Confidence: Medium","confidence":"","size":29,"edges":193,"triangles":547,"max_degree":24,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006470","count":7},{"id":"GO:0046272","count":7},{"id":"GO:0006564","count":7},{"id":"GO:0006874","count":7},{"id":"GO:0071577","count":7}]},{"hash":"1486905636949488416","title":"Ribosome biogenesis and translation machinery","description":"The cluster's top GO terms show ribosome biogenesis and translation as dominant themes (GO:0042254 and GO:0006412), with supporting indicators of RNA modification and cell growth (RNA methylation, mitotic cell cycle, transcription). This pattern points to a group of proteins involved in ribosome assembly and protein synthesis, typical of actively dividing or metabolically active cells; a few stress-related terms (ERAD, cadmium response) are likely peripheral annotations.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0030433","count":4},{"id":"GO:0070059","count":4},{"id":"GO:0006412","count":4}]},{"hash":"932450738639192258","title":"Bacterial secondary metabolite biosynthesis","description":"Top GO terms indicate multiple biosynthetic processes for small molecules (antibiotics and vitamins) across bacteria, with others showing catabolic/xenobiotic handling and transport. The strongest shared theme is enzymatic assembly of secondary metabolites (e.g., antibiotic and clavulanic acid biosynthesis, pyridoxine biosynthesis), suggesting a cluster of proteins involved in these biosynthetic pathways rather than a single routine process. Therefore, the label reflects the predominant function of the cluster, despite some divergent terms.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0008615","count":3},{"id":"GO:0000002","count":3},{"id":"GO:0006151","count":2},{"id":"GO:0046300","count":2}]},{"hash":"162819744785719431","title":"mRNA Splicing and Translation Initiation","description":"The cluster is dominated by RNA-level processes: spliceosome-mediated mRNA splicing, mRNA modification, and the formation of the translation preinitiation complex, with additional links to regulatory ncRNA\u2013mediated gene silencing. Some terms are obsolete, but the core theme ties to RNA processing and early translation steps, suggesting a cohesive splicing/translation regulation cluster.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":5},{"id":"GO:0075525","count":3},{"id":"GO:1901407","count":3},{"id":"GO:0006378","count":3},{"id":"GO:1902625","count":3}]},{"hash":"620090856028674000","title":"Reproductive and Skeletal Development","description":"The dominant GO terms point to developmental and reproductive processes\u2014gonadotropin-releasing hormone response, ovarian follicle development, copulation, and skeletal/muscle/palate development\u2014suggesting the cluster groups genes involved in morphogenesis during reproduction and skeletal formation. A few terms are unrelated, but the core signal supports this theme.","confidence":"Medium","size":29,"edges":67,"triangles":84,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0097211","count":1},{"id":"GO:2000354","count":1},{"id":"GO:0048747","count":1},{"id":"GO:0060021","count":1},{"id":"GO:0001501","count":1}]},{"hash":"938259669967836254","title":"Neuronal development and synaptic plasticity","description":"The cluster is strongly enriched for neural-related functions: long-term synaptic potentiation, dendritic spine morphogenesis, neurotransmitter secretion, visual perception, and social behavior, which together point to brain development and synaptic signaling. There are some non-neural terms like heart development and axial mesoderm formation, but the predominance of neural and synaptic terms suggests the core theme is neuronal development and synaptic function/plasticity.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0060291","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0035176","count":3},{"id":"GO:0048320","count":3}]},{"hash":"1456444241764025772","title":"Embryonic development and cardiac formation","description":"Based on the top GO terms, the cluster centers on developmental processes with a clear emphasis on cardiac development and electrophysiology (heart development, regulation of SA node and atrial action potential), alongside broader embryogenesis signals (blastocyst formation, anterior/posterior pattern specification). Some terms (calcium transport, Rho signaling, regulatory ncRNA silencing) reflect signaling and morphogenesis, while a few outliers (chitin-based cuticle, podosome assembly) may arise from cross-species annotations. Overall, the theme is embryonic development with a cardiac formation focus.","confidence":"Medium","size":29,"edges":35,"triangles":9,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0008363","count":9},{"id":"GO:0070588","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0031047","count":3}]},{"hash":"738136390218783435","title":"Translation Machinery and RNA Metabolism","description":"The top GO terms are dominated by translation-related processes: cytoplasmic translation, general translation, translational termination, and selenocysteine incorporation, with supporting signals from tRNA modification and related RNA turnover. The presence of deadenylation-dependent mRNA decay links mRNA stability to translation, while some terms point to growth-related contexts such as cell cycle and glial proliferation and stress responses like antibiotic exposure, which can intersect with translational control mechanisms.","confidence":"High","size":29,"edges":311,"triangles":1864,"max_degree":28,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":13},{"id":"GO:0002181","count":7},{"id":"GO:0046677","count":7},{"id":"GO:0007049","count":5},{"id":"GO:0006400","count":5}]},{"hash":"556217970709263311","title":"Calcium-Driven Muscle and Vascular Regulation","description":"The top GO terms cluster around calcium release into the cytosol, muscle contraction/relaxation (including smooth muscle), and vascular permeability, with related signaling from prostaglandin and hormone pathways and links to thermogenic/metabolic responses. This points to a theme of calcium-mediated control of muscle function and vascular/hormonal regulation, with metabolic context, rather than disparate processes. Confidence in this cohesive theme is high.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":7},{"id":"GO:0007626","count":6},{"id":"GO:0071502","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0002024","count":6}]},{"hash":"606577007013871444","title":"Neuronal ion transport and synaptic signaling","description":"The cluster is dominated by GO terms for sodium and potassium ion transmembrane transport, excitatory postsynaptic potentials, and long-term synaptic potentiation, complemented by behavior-related terms (startle, forward locomotion, social behavior) and a fish-specific sensory development term (anterior lateral line development). This pattern points to proteins involved in neural signaling and sensorimotor circuits that regulate movement and social behaviors in aquatic species.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":9},{"id":"GO:0071805","count":9},{"id":"GO:1900273","count":6},{"id":"GO:0001661","count":6},{"id":"GO:0060079","count":6}]},{"hash":"939350651107388250","title":"Glutamatergic signaling and sensory behavior","description":"The cluster is dominated by neural and behavioral functions: glutamatergic synaptic transmission, regulation of sensory perception of pain, locomotory behavior, prepulse inhibition, and responses to psychoactive drugs (morphine, amphetamine), as well as visual learning. Ion transporter terms (sodium/potassium transmembrane transport) support neuronal excitability, reinforcing a theme of neural communication and sensory/motor behavior. A heart development term is present but does not define the core function of the cluster. Overall, the proteins appear to cluster around neural signaling and behavior, justifying the label.","confidence":"High","size":29,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0035249","count":4},{"id":"GO:0043278","count":3}]},{"hash":"822678186648334628","title":"Embryonic Development and Morphogenesis","description":"The top GO terms point to broad developmental and morphogenetic processes across tissues\u2014endothelial barrier establishment, cartilage morphogenesis, left/right patterning, placental and endocrine development, EMT in heart formation, and nervous system morphogenesis. This convergence suggests a cluster of proteins involved in embryonic development and organogenesis rather than a single pathway, supporting a label like Embryonic Development and Morphogenesis.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903142","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060972","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0035270","count":6}]},{"hash":"869835391688115350","title":"Developmental Regulation and Innate Immune Signaling","description":"This cluster centers on transcriptional regulation (RNA Pol II\u2013mediated, both positive and negative), developmental processes (midbrain development, post-embryonic development, multicellular organism growth), and innate immune responses (defense against Gram-positive bacteria and fungi, response to LPS), along with related signaling pathways such as GPCR-PLC and coagulation. The combination suggests a theme of developmental gene regulation intertwined with innate immune signaling. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":17},{"id":"GO:0030901","count":13},{"id":"GO:0035264","count":11},{"id":"GO:0045944","count":11},{"id":"GO:0050830","count":10}]},{"hash":"124665344982693613","title":"Glycinergic Synaptic Transmission and Glycine Transport","description":"These proteins are enriched for glycinergic synaptic signaling (GO:0060012) and glycine import/transport (GO:0036233), with additional terms related to regulation of glycinergic transmission. While there are some brain-development terms and glial growth signals present, the strongest, coherent theme is glycine-mediated neurotransmission at synapses and associated transport. This makes the label a focused representation of the cluster\u2019s core function.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060012","count":4},{"id":"GO:0042066","count":3},{"id":"GO:1905847","count":3},{"id":"GO:0015824","count":3},{"id":"GO:0036233","count":3}]},{"hash":"452429694572115516","title":"Neuronal development and synaptic signaling","description":"The cluster shows strong enrichment for neural-related processes: long-term synaptic potentiation, excitatory postsynaptic potential, visual perception, axonogenesis, and Schwann cell development, pointing to neural development and synaptic function. There are also cell-cycle and apoptotic terms, which may reflect broader developmental regulation, and a plant ABA signaling term that could be annotation noise. Overall, the dominant neural and synaptic terms support this label.","confidence":"Medium","size":29,"edges":182,"triangles":396,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000086","count":24},{"id":"GO:0000278","count":24},{"id":"GO:0043065","count":24},{"id":"GO:0009738","count":24},{"id":"GO:0060291","count":24}]},{"hash":"894074452547799601","title":"Negative regulation of signaling and synaptic organization","description":"The Top Terms show widespread negative regulation across signaling pathways (MAPK/ERK, PI3K/AKT, T cell receptor signaling) and components of synaptic architecture (postsynaptic density assembly, synaptic vesicle clustering). The common thread appears to be inhibition or modulation of signaling activities coupled with synaptic organization, suggesting a cluster of proteins that function as signaling regulators with roles at synapses.","confidence":"Medium","size":29,"edges":402,"triangles":3550,"max_degree":28,"top_function":null,"top_go_terms":[{"id":"GO:0000200","count":21},{"id":"GO:0070373","count":21},{"id":"GO:0050860","count":21},{"id":"GO:0007049","count":13},{"id":"GO:0051898","count":13}]},{"hash":"90883086137417820","title":"Ubiquitin-Mediated Immune Regulation","description":"The cluster is dominated by ubiquitination-related terms (ubiquitin-dependent protein catabolic process, K33-linked ubiquitination, regulation of protein ubiquitination) and contains several immune-related terms (mast cell cytokine production, dendritic cell differentiation, IgE isotype regulation), suggesting a cohesive role in ubiquitin-driven regulation of immune signaling and protein turnover.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":25},{"id":"GO:0032764","count":21},{"id":"GO:2000312","count":21},{"id":"GO:1904431","count":21},{"id":"GO:0045497","count":21}]},{"hash":"1816192950955767028","title":"Heart and neural development","description":"Proteins in this cluster show strong enrichment for developmental and morphogenesis processes, especially those related to heart and nervous system formation. Terms like sinus venosus morphogenesis, floor plate development, hindbrain morphogenesis, and outflow tract morphogenesis point to cardiogenesis and neurogenesis; mesenchyme development further supports a developmental program. While a plant-related term appears among the list, the dominant pattern indicates vertebrate heart and neural development.","confidence":"High","size":29,"edges":406,"triangles":3654,"max_degree":28,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":26},{"id":"GO:0010374","count":25},{"id":"GO:0035481","count":25},{"id":"GO:0042981","count":25},{"id":"GO:0033504","count":25}]},{"hash":"1799668528432384076","title":"Embryonic development and organ morphogenesis","description":"The top GO terms cluster around embryogenesis, including cartilage morphogenesis, left/right patterning, placenta and endocrine system development, and EMT-related heart cushion formation. These reflect a common theme of tissue morphogenesis and developmental lineage specification across multiple organs, rather than a single tissue-specific function. The proteins likely participate in broad developmental programs governing organogenesis and pattern formation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0060707","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0060806","count":5}]},{"hash":"786217780680413479","title":"RNA processing and ribosome biogenesis","description":"The top GO terms cluster around RNA metabolism and translation machinery\u2014splicing, mRNA decay/no-go decay, transcription termination, and ribosome biogenesis\u2014suggesting a cohesive focus on RNA processing and assembly of the protein synthesis apparatus. Some terms (e.g., B cell signaling, ubiquitination regulation) are less central and may reflect broader functions or noise, but the dominant theme is RNA processing and ribosome biogenesis.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0031397","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0042273","count":2}]},{"hash":"2258320854318933490","title":"GPCR-cAMP Cardiovascular Signaling and Metabolic Response","description":"The cluster is dominated by GO terms tied to GPCR signaling and adenylate cyclase activation, including positive regulation of blood pressure and activation of adenylate cyclase, suggesting central GPCR-cAMP control of cardiovascular function. Additional terms for electron transport chain and thermogenesis point to energy metabolism, while xenobiotic and LPS responses indicate broader stress and immune responsiveness, indicating an integrated signaling network linking cardiovascular regulation with metabolism and environmental responses.","confidence":"Medium","size":29,"edges":32,"triangles":3,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":13},{"id":"GO:0010579","count":13},{"id":"GO:0022900","count":13},{"id":"GO:0019233","count":12},{"id":"GO:0007190","count":11}]},{"hash":"1116616974994173678","title":"Axon Guidance and Neural Crest Migration","description":"The terms point strongly to neural development, especially axon guidance and neuronal projection: axonal fasciculation, sympathetic and branchiomotor neuron axon guidance/extension, neural crest migration, trigeminal nerve organization, semaphorin-plexin signaling, and cell adhesion. Together they describe coordinated neural wiring and guidance cues during development.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007413","count":11},{"id":"GO:0097491","count":10},{"id":"GO:0051965","count":10},{"id":"GO:0036486","count":10},{"id":"GO:1902287","count":10}]},{"hash":"375754549311546469","title":"Embryonic development and organ morphogenesis","description":"The proteins are enriched for diverse developmental GO terms across tissues (pancreas, cartilage, midbrain, placenta, etc.), including morphogenesis and pattern formation, plus regulatory transcription control. This points to a cohesive theme centered on embryonic organ development and morphogenesis.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0003323","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0060707","count":5}]},{"hash":"1536110991469753930","title":"Transmembrane transport of sugars, vitamins, and xenobiotics","description":"The cluster is dominated by GO terms tied to membrane transport of small molecules\u2014L-ascorbic acid and dehydroascorbic acid (vitamin C), D-xylose, and D-glucose\u2014plus sodium-dependent organic cation transport and xenobiotic transport. The inclusion of glucose uptake in response to insulin and osmotic-stress responses reinforces a common role in nutrient and solute transport and osmoregulation, with some ancillary effects on epithelial maintenance and senescence regulation. ","confidence":"High","size":29,"edges":75,"triangles":36,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0019852","count":28},{"id":"GO:0042908","count":28},{"id":"GO:0070837","count":28},{"id":"GO:0015753","count":28},{"id":"GO:0006970","count":28}]},{"hash":"1864471298284931720","title":"Cardiovascular development and signaling","description":"GO terms cluster around cardiovascular development, heart morphogenesis, and venous endothelial differentiation, with additional support from transcriptional regulation, Notch signaling in heart-field proliferation, mechanotransduction, and signaling modulation (GTPase activity, protein kinase activity).","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0007568","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0003270","count":3},{"id":"GO:0048549","count":3}]},{"hash":"287688637494084430","title":"Neural development and axon guidance","description":"The cluster shows a clear enrichment for neural-related terms, including nervous system development (GO:0007399), axonal fasciculation (GO:0007413), sympathetic neuron projection guidance (GO:0097491), olfactory lobe development (GO:0021988), collateral sprouting (GO:0048672), and positive regulation of synapse assembly (GO:0051965), suggesting a core theme around neural development and connectivity. A few immune and skeletal terms (complement activation, ossification) are present but appear less central to the dominant neural pattern, indicating possible pleiotropy or broader roles. Overall, the proteins likely participate in neural development and synapse formation. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":4},{"id":"GO:0007399","count":3},{"id":"GO:0048672","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0006957","count":3}]},{"hash":"2056213472997058111","title":"ECM-Driven Development and Immune Signaling","description":"The top GO terms focus on extracellular matrix interactions and signaling (ECM-cell signaling, cartilage condensation) along with organ morphogenesis (metanephric tubule and lymph vessel development). Immune-related terms (complement activation via lectin pathway, C-type lectin receptor signaling) indicate innate immune involvement. Together, these suggest a cluster of proteins coordinating ECM-mediated developmental processes with innate immune signaling.","confidence":"Medium","size":29,"edges":11,"triangles":1,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":21},{"id":"GO:0001502","count":17},{"id":"GO:0001867","count":15},{"id":"GO:0035426","count":12},{"id":"GO:0072218","count":12}]},{"hash":"1699364760019954225","title":"Embryonic development and organ morphogenesis","description":"This cluster centers on genes involved in broad developmental processes across multiple tissues\u2014skeletal muscle, cartilage, endocrine organs, heart/endocardial cushion EMT, left-right patterning, placenta/trophoblast differentiation, and pancreatic cell development\u2014indicating a general embryonic development and organogenesis theme rather than a single pathway. The lack of direct interaction edges does not undermine this shared functional context.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007519","count":7},{"id":"GO:0051216","count":7},{"id":"GO:0035270","count":7},{"id":"GO:0003198","count":7},{"id":"GO:0060536","count":7}]},{"hash":"1967620373464722452","title":"Developmental and Immune Regulation","description":"The GO terms cluster around broad regulatory roles in development across tissues (pigmentation, BMP signaling, olfactory lobe development, salivary gland morphogenesis, megakaryocyte development, axon regeneration) and immune processes (cytokine production, neutrophil extravasation, CD8+ T cell proliferation). This points to a general theme of regulatory development and immune signaling rather than a single, cohesive pathway, making a Developmental and Immune Regulation label plausible for this cluster.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0048070","count":4},{"id":"GO:0035855","count":4},{"id":"GO:0030513","count":4},{"id":"GO:0021988","count":3},{"id":"GO:0060445","count":3}]},{"hash":"1047530165501725864","title":"Developmental and Immune Signaling Pathways","description":"The top GO terms point to multiple signaling cascades (Rho, ERK/MAPK, NF-\u03baB, PI3K) and pathways like B cell receptor signaling and innate immunity, alongside developmental processes (angiogenesis, heart and CNS development, dendritic spine regulation). This suggests a cohesive theme of signal transduction governing development and immune-related functions, despite diversity in specific terms.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0051092","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0050853","count":5}]},{"hash":"482849027897993708","title":"Neural development and synaptic signaling","description":"This cluster is enriched for nervous system development, dendrite development, cochlea morphogenesis, and regulation of synaptic vesicle endocytosis, indicating a neural development and synaptic regulation theme. While a few terms touch on general cellular processes (cell division, ribosomal export), the dominant neural/synaptic terms support this labeling.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":5},{"id":"GO:0016358","count":5},{"id":"GO:0051301","count":4},{"id":"GO:1900242","count":4},{"id":"GO:0030838","count":4}]},{"hash":"617892272092229825","title":"Zinc Ion Homeostasis and Transport","description":"This cluster shows multiple zinc-related GO terms (zinc ion homeostasis, response to zinc ion, zinc ion transmembrane transport, negative regulation of zinc ion import) plus related metal ion homeostasis terms (iron/cobalt), indicating a cohesive theme centered on zinc handling and transport within the cell. The presence of zinc-specific processes outweighs the mixed other metal-ion terms, supporting a zinc-focused functional label.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055072","count":4},{"id":"GO:0098914","count":3},{"id":"GO:0050976","count":3},{"id":"GO:0006882","count":3},{"id":"GO:0010043","count":3}]},{"hash":"70269826673882739","title":"Embryonic development and morphogenesis","description":"The cluster features GO terms tied to placenta-related development (trophoblast giant cell differentiation, placenta development), organ morphogenesis (cartilage morphogenesis, heart-related EMT), and patterning (left-right formation), indicating a cohesive role in embryogenesis and organ formation. Some terms relate to broader developmental regulation, but the dominant theme centers on embryonic tissue formation and morphogenesis.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":6},{"id":"GO:0060536","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0060806","count":5}]},{"hash":"290858719038874292","title":"Neuronal signaling and ion transport","description":"This cluster is enriched for ion transport terms (sodium, potassium, calcium) and for neuron-specific signaling processes (ionotropic glutamate receptor signaling, serotonin metabolism), coupled with behavioral and sensory development terms (forward locomotion, social behavior, anterior lateral line development). These together suggest a group of proteins involved in neural signaling and ion channel function, likely underpinning neural activity and sensory-driven behaviors in a fish context.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0042428","count":3},{"id":"GO:0035176","count":3},{"id":"GO:0010157","count":3}]},{"hash":"1827989137324863049","title":"Apoptosis and Cytoskeletal/Developmental Regulation","description":"These terms cluster around apoptotic signaling and mitochondrial membrane permeabilization, alongside cytoskeletal and cell-movement functions (GTPase regulation, cellular response to mechanical stimulus, spindle assembly, epithelial migration) and developmental processes (oskar mRNA translation, posterior head segmentation). The combination suggests a theme of cell fate decision and division coupled with dynamic cytoskeletal remodeling during development, with ubiquitination supporting protein turnover.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0046011","count":3},{"id":"GO:1902108","count":3},{"id":"GO:0007427","count":3}]},{"hash":"1559905168835123882","title":"Heart development and cardiac signaling","description":"Top GO terms indicate strong ties to cardiovascular biology, including heart development, relaxation of cardiac muscle, ERK signaling, and potassium ion transport that influences cardiac function, with additional links to coagulation and extracellular matrix components; together these suggest a cluster of proteins involved in cardiovascular development and heart signaling pathways.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":2},{"id":"GO:0048339","count":2},{"id":"GO:0042742","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0007195","count":2}]},{"hash":"2220207272813565106","title":"Tissue morphogenesis and ECM remodeling","description":"This cluster centers on terms related to collagen fibril organization and its regulation, responses to mechanical stimulus, and various morphogenesis processes (otolith morphogenesis, branching morphogenesis of a nerve, axonal fasciculation). These suggest roles in tissue development where extracellular matrix dynamics and mechanotransduction drive shape and connectivity. Some outlier terms (immune signaling, hormone sensing) are present but do not define the main theme. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0030199","count":2},{"id":"GO:0051770","count":2},{"id":"GO:0002755","count":2},{"id":"GO:1904027","count":2}]},{"hash":"1422359851735545113","title":"Cytoskeletal remodeling and polarity in sensory epithelia","description":"This cluster centers on cytoskeletal regulation (Rho signaling, stress fiber dynamics), integrin-mediated adhesion, and polarity establishment, with links to sensory and epithelial contexts (brush border/microvilli, equilibrioception, eye morphogenesis, receptor internalization). The convergence of these terms suggests a cohesive role in coordinating cytoskeleton, adhesion, and polarity in sensory epithelial tissues.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0009408","count":4},{"id":"GO:0033628","count":4},{"id":"GO:0051497","count":4},{"id":"GO:0050957","count":4}]},{"hash":"1940484435293791497","title":"Circadian neural signaling and ion transport","description":"These proteins cluster around circadian regulation of sleep/wake cycles and neuronal signaling, highlighted by calcium, sodium, and potassium ion transport and GABA pathways. The associated behavioral terms (startle, locomotory behavior, conditioned taste aversion) point to neural circuit control of reflexes and learning, with a note of skeletal muscle growth suggesting neuromuscular connections. Collectively, this suggests a group involved in circadian-modulated neural excitability and signaling.","confidence":"High","size":28,"edges":19,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045188","count":22},{"id":"GO:0098703","count":22},{"id":"GO:0001964","count":22},{"id":"GO:0071805","count":21},{"id":"GO:0007214","count":20}]},{"hash":"713667261986652928","title":"GTPase signaling and vesicle trafficking in plant development","description":"The top GO terms point to positive regulation of GTPase activity, nuclear import, vesicle transport from ER to Golgi, and developmental processes such as root development and cell migration, with meiotic components suggesting broader cellular reorganization during reproduction. Together these indicate a cluster of proteins involved in GTPase-driven signaling and intracellular trafficking that supports plant development and cellular dynamics. Stress granule disassembly also aligns with cytoplasmic remodeling during these processes. ","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0006607","count":7},{"id":"GO:0048364","count":7},{"id":"GO:0007143","count":6},{"id":"GO:0015991","count":6}]},{"hash":"1897909788226480069","title":"Developmental patterning and cell-cycle control","description":"The cluster includes terms tied to embryonic development (posterior head segmentation, epithelial cell migration in the tracheal system, regulation of oskar mRNA translation) alongside core cell-cycle processes (mitotic cell cycle, attachment of spindle microtubules to kinetochores) and genome maintenance/apoptosis (nucleotide-excision repair, regulation of transcription, apoptotic processes, mitochondrial membrane permeability regulation). This mix suggests a shared theme of coordinating development with cell division and genome integrity, rather than a single isolated pathway, hence a label focused on development and cell-cycle coordination.","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006289","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0046011","count":2},{"id":"GO:1902108","count":2}]},{"hash":"1248276841206043913","title":"Neuronal signaling and behavior","description":"The terms cluster around neurotransmitter signaling (GABA, acetylcholine, histamine) and behavioral/sensory processes (conditioned taste aversion, locomotory behavior, sensory processing, cocaine response), indicating a common theme of neuronal communication modulating behavior.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007214","count":11},{"id":"GO:0001661","count":11},{"id":"GO:0007626","count":10},{"id":"GO:0045759","count":10},{"id":"GO:0042220","count":10}]},{"hash":"2084791053685914693","title":"RNA Processing and Splicing Regulation","description":"The cluster is dominated by GO terms tied to post-transcriptional RNA handling: mRNA stability regulation under stress, mRNA splicing via the spliceosome, mRNA modification, regulatory ncRNA-mediated gene silencing, and related maturation processes. Although some terms are obsolete, the consistent theme is RNA processing and regulation of gene expression at the RNA level, including splicing and stability, potentially linked to stress responses. This supports a concise label focused on RNA maturation and processing functions.","confidence":"High","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":24},{"id":"GO:1901407","count":19},{"id":"GO:0006378","count":19},{"id":"GO:0045292","count":19},{"id":"GO:0075525","count":18}]},{"hash":"1166718931367729248","title":"RNA processing and mRNA maturation","description":"This cluster is enriched for mRNA processing functions: spliceosome-mediated splicing, polyadenylation, RNA modification, mRNA stability under stress, and ncRNA-mediated gene silencing\u2014together pointing to post-transcriptional maturation and regulation of gene expression.","confidence":"High","size":28,"edges":343,"triangles":2486,"max_degree":27,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":20},{"id":"GO:0010610","count":20},{"id":"GO:0045292","count":19},{"id":"GO:1901407","count":17},{"id":"GO:0075525","count":16}]},{"hash":"1514999979585717866","title":"Ribosome Biogenesis and Translation","description":"The strongest signals are ribosome biogenesis and translation (GO:0042274, GO:0006412, GO:0042254), with accompanying RNA processing (splicing). A subset of terms points to various developmental processes (cartilage morphogenesis, left-right pattern formation, trophoblast giant cell differentiation, endocrine system development, placental and pancreatic development). This pattern suggests a cluster enriched for core protein-synthesis machinery and some developmental roles in specific contexts, rather than a single cohesive developmental pathway. ","confidence":"Medium","size":28,"edges":15,"triangles":6,"max_degree":5,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042274","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0060536","count":3}]},{"hash":"658522408243992489","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":370,"triangles":3081,"max_degree":27,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0070317","count":8},{"id":"GO:0000398","count":8},{"id":"GO:0045292","count":8},{"id":"GO:0006369","count":8},{"id":"GO:0000480","count":7}]},{"hash":"2043561297044985698","title":"Unknown","description":"The top GO terms span immune/haemostasis (blood coagulation, complement activation), extracellular matrix remodeling (collagen catabolic), RNA processing (splicing), protein modification (ubiquitination), and various developmental processes, with no clear common function or pathway linking the 28 proteins. The lack of edges/triangles and broad, disparate annotations make a cohesive label unreliable.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0030574","count":2},{"id":"GO:0000350","count":1}]},{"hash":"739585342197298026","title":"Muscle contraction and sarcomere organization","description":"The top GO terms predominantly describe muscle structure and contractile processes\u2014sarcomere organization, muscle filament sliding, and regulation of muscle contraction\u2014indicating the cluster centers on muscle contraction machinery. Some terms reflect broader development contexts (larval cuticle, somite development) but do not override the core muscle-related signals.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0061053","count":1},{"id":"GO:0098789","count":1},{"id":"GO:0072756","count":1},{"id":"GO:0035264","count":1}]},{"hash":"2294692136320584359","title":"Transmembrane Transporters","description":"The cluster is dominated by GO terms for transmembrane transport of ions, sugars, vitamins, and xenobiotics, indicating a set of membrane transporter proteins responsible for moving diverse substrates across membranes. The diversity of substrates and strong transport signal suggest a cohesive transporter function rather than a single-substrate group.","confidence":"High","size":28,"edges":124,"triangles":135,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":6},{"id":"GO:0071805","count":6},{"id":"GO:1900754","count":5},{"id":"GO:0015707","count":5},{"id":"GO:0006855","count":5}]},{"hash":"1584117463627874105","title":"Neuronal Ion Transport and Synaptic Signaling","description":"The cluster is enriched for ion transmembrane transport (sodium and potassium), excitatory postsynaptic potentials, and regulation of synaptic plasticity, along with sensory-related processes (touch, pain) and learning. This combination points to proteins involved in neuronal signaling and activity-dependent plasticity, justifying a label centered on ion transport-linked synaptic function.","confidence":"High","size":28,"edges":118,"triangles":262,"max_degree":26,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035725","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0050975","count":6},{"id":"GO:0060079","count":6},{"id":"GO:0048169","count":6}]},{"hash":"764132821789440592","title":"Sodium and Potassium Ion Transporters","description":"This cluster shows GO terms for sodium and potassium ion transmembrane transport (6 hits each), indicating a shared theme of membrane transporter activity. The presence of RNA processing and gene regulation terms may reflect multifunctional proteins or annotation noise, but the strongest signal is ion transport.","confidence":"Medium","size":28,"edges":110,"triangles":160,"max_degree":24,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0035725","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0075525","count":5},{"id":"GO:1901407","count":5},{"id":"GO:0006378","count":5}]},{"hash":"1257404807597552291","title":"Lymphocyte activation and cytoskeletal migration","description":"The top GO terms point to lymphocyte-related signaling and differentiation (IL-7 response, IL-4 production, B cell maturation, NK T differentiation) together with cytoskeletal remodeling and movement (Rho signaling, lamellipodium assembly, cell migration, increased substrate adhesion-dependent spreading), suggesting a cohesive role in immune cell activation and migration.","confidence":"High","size":28,"edges":87,"triangles":141,"max_degree":19,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:1900026","count":6},{"id":"GO:0098761","count":6},{"id":"GO:0032287","count":6},{"id":"GO:0001865","count":6}]},{"hash":"1176746472214541936","title":"P450-driven xenobiotic and lipid metabolism","description":"The top GO terms are dominated by xenobiotic catabolic processes, omega-hydroxylase P450 pathway, oxylipin biosynthesis, lipid hydroxylation, and various hormone biosynthetic processes (cortisol, brassinosteroid, isoquinoline alkaloid metabolism), which together point to cytochrome P450\u2013mediated metabolism of xenobiotics and lipids as the central activity of this cluster. An outlier term on endothelial adhesion is less defining of the cluster\u2019s primary function. ","confidence":"High","size":28,"edges":28,"triangles":2,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0042738","count":25},{"id":"GO:0097267","count":25},{"id":"GO:0031408","count":25},{"id":"GO:0042369","count":25},{"id":"GO:0019341","count":25}]},{"hash":"2155011399161828513","title":"ECM Remodeling in Cartilage and Skeletal Development","description":"The cluster is enriched for extracellular matrix\u2013related processes (collagen catabolic process, extracellular matrix disassembly) and developmental terms (cartilage development, skeletal muscle tissue development, amelogenesis, midbrain development). This points to coordinated ECM remodeling shaping connective tissue and mineralized structures during development. Broader transcriptional regulation terms are present but less central, while a couple of outliers (chitin catabolic process, lectin pathway activation) may reflect annotation noise or broader functional context.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0051216","count":7},{"id":"GO:0030901","count":7},{"id":"GO:0001867","count":6},{"id":"GO:0097186","count":6}]},{"hash":"34725967445552043","title":"Presynaptic calcium signaling and potassium channel clustering","description":"This cluster is characterized by GO terms tied to presynaptic Ca2+ regulation, long-term synaptic potentiation, and calcineurin-NFAT signaling, indicating activity-dependent synaptic plasticity. The inclusion of voltage-gated potassium channel clustering reinforces a theme of presynaptic excitability modulation and signaling cross-talk. Together these terms suggest a cohesive synaptic signaling/plasticity module.","confidence":"High","size":28,"edges":3,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043388","count":4},{"id":"GO:0045163","count":3},{"id":"GO:0008360","count":3},{"id":"GO:0099509","count":3},{"id":"GO:0032516","count":3}]},{"hash":"47591470791613169","title":"Placental and Embryonic Development","description":"The cluster is dominated by GO terms tied to placental biology and embryogenesis, including trophoblast giant cell differentiation, embryonic placenta development, and endocrine system development, with supporting signals around forebrain and cartilage morphogenesis and general transcription/mitosis involved in development. This suggests a cohesive theme of placental/embryonic lineage specification and organogenesis.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0003094","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0048146","count":2}]},{"hash":"554128300916099248","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0000447","count":4},{"id":"GO:0000480","count":3},{"id":"GO:0000472","count":3},{"id":"GO:0000244","count":2}]},{"hash":"1020444128571830348","title":"Glutamatergic Synaptic Signaling and Plasticity","description":"This cluster is dominated by neural communication and plasticity terms: glutamatergic synaptic transmission, long-term potentiation and depression, regulation of short-term synaptic plasticity, and ion transport for neuronal excitability (sodium and potassium). The inclusion of behavioral terms like ethanol and morphine response, and social behavior, supports a neural signaling theme influencing behavior. A single osteoblast fate term appears as noise, but does not override the neuronal focus.","confidence":"High","size":28,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0048149","count":3},{"id":"GO:0035176","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:1900273","count":3}]},{"hash":"1566958295278813728","title":"Neural signaling and behavior","description":"The top GO terms point to nervous system function and behavior, including response to morphine, serotonin metabolism, social behavior, conditioned taste aversion, and forward locomotion, with ion transport (sodium/potassium) supporting neuronal activity. Immune-related terms are present but do not define a single cohesive pathway, so the neural/behavioral theme remains the best explanation for this cluster.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":5},{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0001661","count":4},{"id":"GO:0045842","count":4}]},{"hash":"285622159649623836","title":"Vertebrate neural morphogenesis and Wnt/PCP signaling","description":"The top GO terms cluster around neural development and tissue morphogenesis (neural plate morphogenesis, cochlea morphogenesis, planar cell polarity in neural tube closure) and signaling pathways (canonical Wnt, Rho signaling) with cytoskeletal dynamics (filopodium assembly). Additional neuronal terms (GABA signaling, light-detection-related vision) support a neural-development theme. A distant mitochondrial term (electron transport chain) may reflect general cellular energy needs or broad annotation. Overall, the cluster is best described as vertebrate neural morphogenesis coordinated by Wnt/PCP signaling and related pathways.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022900","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0090103","count":2},{"id":"GO:0090179","count":2},{"id":"GO:0001839","count":2}]},{"hash":"1475160075173341257","title":"Developmental Regulation","description":"This cluster shows enrichment for transcription-related GO terms (DNA-templated transcription and its regulation) together with a range of tissue- and organ-development terms (eye/antenna, palate, skeletal/muscle, ovarian follicle, copulation). This pattern suggests a set of proteins that broadly regulate development through transcriptional control across multiple tissues rather than a single pathway.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045316","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0007469","count":1},{"id":"GO:0097211","count":1}]},{"hash":"1484241302820877737","title":"Multicellular Development and Growth Regulation","description":"The GO terms point to overarching developmental and growth-related processes\u2014multicellular organism development, growth, pigmentation, and synaptic plasticity\u2014supported by regulatory activities on GTPase signaling, apoptotic pathways, and ubiquitin-mediated proteolysis, as well as cell cycle and division. Even with no observed edges, the shared functional themes suggest a cluster tied to developmental regulation and growth control in multicellular contexts.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0007049","count":3},{"id":"GO:0051301","count":3}]},{"hash":"817243138390368907","title":"Inflammation-Linked Apoptosis and Ubiquitination","description":"The Top Terms include apoptosis, pyroptotic inflammatory response, innate immune response, and protein ubiquitination, suggesting a cohesive module of immune-driven cell death and its regulation. While some terms like coagulation reflect broader inflammatory processes, the core theme centers on programmed cell death linked to innate immunity and ubiquitin-regulated signaling.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:1990001","count":7},{"id":"GO:0016567","count":7},{"id":"GO:0090307","count":7},{"id":"GO:0070269","count":7},{"id":"GO:0006915","count":7}]},{"hash":"1387366572453520917","title":"Skeletal, Muscle, and Reproductive Development","description":"These proteins show enrichment for developmental processes across skeletal/muscle and reproductive tissues, including skeletal system development, muscle cell development, ovarian follicle development, and copulation. Additional terms like roof of mouth development and GnRH response reinforce a shared theme of coordinated development in mesoderm-derived structures and reproductive organs.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007620","count":2},{"id":"GO:0097211","count":1},{"id":"GO:2000354","count":1},{"id":"GO:0048747","count":1},{"id":"GO:0060021","count":1}]},{"hash":"522397147737463167","title":"Retinal Photoreceptor Maintenance and Signaling","description":"The top GO terms cluster around the visual system, especially photoreceptor maintenance and visual learning, together with phototransduction-related GPCR signaling, calcium release, and ERK pathway regulation. While a few terms mention temperature response or cytolysis, the dominant themes point to retinal photoreceptor function and signaling. This suggests a coherent module of vision-related processes.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0051209","count":7},{"id":"GO:0008542","count":5}]},{"hash":"1515670953032435708","title":"Embryonic organogenesis across tissues","description":"This cluster is dominated by broad development terms across multiple organs (eye/retina, lung, bone, pancreas) and neural regulation, plus general transcriptional control. The recurring themes are eye development, organ morphogenesis, and neural involvement in organ formation, suggesting a shared function in embryonic organogenesis and tissue patterning rather than a single, specific pathway.","confidence":"Medium","size":28,"edges":370,"triangles":3081,"max_degree":27,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0002087","count":16},{"id":"GO:0002076","count":16},{"id":"GO:0060041","count":16},{"id":"GO:0006366","count":15},{"id":"GO:0060441","count":11}]},{"hash":"1011083720659712507","title":"Transmembrane Nutrient and Xenobiotic Transporters","description":"These proteins are enriched for GO terms describing transport across membranes for diverse substrates (vitamins, xenobiotics, sialic acid, nitrite, fucose, 4-hydroxyphenylacetate). While there are some unrelated terms (heart development, immune response), the dominant theme is membrane transport of various nutrients and xenobiotics, suggesting they function as a coherent group of transmembrane transporter proteins.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":6},{"id":"GO:0006855","count":4},{"id":"GO:0015739","count":4},{"id":"GO:0042891","count":4},{"id":"GO:0050731","count":4}]},{"hash":"436391037613795414","title":"ECM remodeling and immune signaling","description":"The cluster is enriched for terms related to extracellular matrix organization (collagen fibril organization, integrin-mediated adhesion) and immune/inflammatory processes (proteolysis, IL-1 response, complement pathway regulation, eosinophil migration). A couple of terms touch on reproduction and melanocyte differentiation, but the dominant theme points to ECM dynamics coupled with immune signaling. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:0001542","count":1},{"id":"GO:0035419","count":1},{"id":"GO:0030199","count":1},{"id":"GO:0001869","count":1}]},{"hash":"286554470457853287","title":"Proteostasis and Vesicle Trafficking","description":"This cluster is dominated by GO terms related to ubiquitin-dependent proteolysis, including proteasomal degradation and MVB (multivesicular body) sorting, as well as post-translational targeting to the ER and MVB assembly. Together these point to a shared role in protein quality control and intracellular trafficking/organelle maintenance (with a few outliers like memory-related terms that may reflect annotation noise). ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032436","count":2},{"id":"GO:0007616","count":2},{"id":"GO:0031915","count":2},{"id":"GO:0048142","count":2},{"id":"GO:0042407","count":2}]},{"hash":"363532556137942715","title":"Ribosome Biogenesis and RNA Processing","description":"The cluster is enriched for ribosome-related processes: maturation of rRNA, biogenesis of the large ribosomal subunit, and DNA-templated transcription, indicating links to nuclear gene expression and ribosome assembly; while a few terms point to neural development and apoptosis, the dominant functional signal is RNA processing and ribosome production. Obsolete GO terms are present but do not alter the core theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0007420","count":3},{"id":"GO:0090502","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0051301","count":3}]},{"hash":"1375250115998106908","title":"Ubiquitin-Dependent Protein Regulation","description":"The cluster is dominated by GO terms related to ubiquitin-mediated proteolysis and ubiquitination regulation (e.g., ubiquitin-dependent protein catabolic process, K33-linked ubiquitination, negative regulation of ubiquitination), with additional terms touching signaling and development (B cell receptor signaling, muscle and kidney development). This suggests a cohesive theme around ubiquitin-regulated signaling and developmental processes.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":20},{"id":"GO:2000312","count":16},{"id":"GO:1990390","count":16},{"id":"GO:0031397","count":16},{"id":"GO:0050853","count":16}]},{"hash":"2125077787232726348","title":"Developmental gene expression regulation","description":"This cluster centers on developmental processes (neural tube closure, multicellular development/growth, seminiferous tubule development) and gene expression control (mRNA splicing, transcription, histone acetylation). The inclusion of cell-cycle and GTPase regulation hints at coordinated signaling and proliferation during development, suggesting the proteins work together to regulate gene expression and chromatin state in developmental contexts.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0043966","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0035264","count":4}]},{"hash":"1027247578938501814","title":"Pain and Vision Sensory Signaling","description":"The cluster is dominated by GO terms tied to sensory perception, especially pain, temperature response, and vision (retina development and phototransduction), along with calcium signaling and neuropeptide pathways that underpin neurotransmission. Together, these terms point to proteins involved in sensory signaling in the nervous system, spanning nociception and visual pathways; the presence of morphine response and neuropeptide signaling reinforces a neural signaling theme. Confidence in this label is high because of the cohesive, multi-modal sensory signaling pattern across the terms.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":8},{"id":"GO:0071502","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0051209","count":6},{"id":"GO:0060041","count":5}]},{"hash":"253667277803205194","title":"Unknown","description":"The top GO terms span neural differentiation (oligodendrocyte differentiation), pain and immune-related responses (response to pain; chemokine production), structural/polarity aspects (establishment of epithelial cell polarity), protein turnover (proteasome regulatory particle assembly), stress responses (response to cold), signaling pathways (Wnt signaling), and cardiac electrophysiology (regulation of SA node cell action potential). This diverse mix does not converge on a single coherent function or process, so there isn\u2019t a confident, representative label to assign.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048709","count":5},{"id":"GO:0048265","count":5},{"id":"GO:1904357","count":4},{"id":"GO:0090162","count":4},{"id":"GO:0070682","count":4}]},{"hash":"2284524718953251565","title":"Neuronal signaling and innervation","description":"The top GO terms point to neural functions: innervation, CNS development, GPCR acetylcholine receptor signaling, and intracellular signal transduction with GTPase regulation, suggesting a coherent theme of neuronal signaling and nervous system development. A few terms (glomerular basement membrane development, lipoteichoic acid biosynthesis) are less related and may reflect broader roles or annotation noise, but the core pattern supports neural signaling. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060384","count":4},{"id":"GO:0035556","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0007213","count":3},{"id":"GO:0007417","count":3}]},{"hash":"378208483964567678","title":"Muscle contraction regulation and sarcomere organization","description":"The GO terms cluster around sarcomere organization, muscle filament sliding, and regulation of contraction, including both positive and negative regulation of ATP-dependent activity, as well as muscle fiber-type transitions and even backward locomotion. This points to a cohesive set of proteins involved in the contractile machinery and its regulatory control (with proteolysis suggesting turnover/remodeling in muscle). ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0032780","count":1},{"id":"GO:0006940","count":1},{"id":"GO:0030049","count":1}]},{"hash":"1583569595628557998","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051209","count":3},{"id":"GO:0007186","count":2},{"id":"GO:0046849","count":2},{"id":"GO:0045599","count":2},{"id":"GO:0050427","count":2}]},{"hash":"272264517914462997","title":"Coagulation and Complement-Mediated Defense","description":"This cluster is enriched for blood coagulation and complement activation terms (classical and lectin pathways), with additional defense against fungus, pointing to innate immune defense coupled with hemostasis; though some terms are peripheral, the dominant signals support this theme.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007596","count":10},{"id":"GO:0006958","count":10},{"id":"GO:0000122","count":10},{"id":"GO:0050832","count":9},{"id":"GO:1900738","count":9}]},{"hash":"56004738526601571","title":"Mitochondrial Translation and Respiration","description":"The top GO terms cluster around translation (cytoplasmic and general translation) and mitochondrial energy production (mitochondrial respiratory chain complex II assembly, proton motive force-driven ATP synthesis), suggesting a group of proteins involved in protein synthesis and mitochondrial energy metabolism. Some other terms (copper homeostasis, vacuole targeting, angiogenesis, transcription) appear less central and may reflect broader cellular context or annotation noise. ","confidence":"Medium","size":27,"edges":262,"triangles":1426,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0070584","count":3},{"id":"GO:0002181","count":2},{"id":"GO:1903833","count":2},{"id":"GO:0042777","count":2}]},{"hash":"1753490712504031882","title":"Neural development and synaptic organization","description":"Neural differentiation, neuroligin clustering at postsynaptic membranes, and regulation of neuron apoptotic processes dominate the terms, indicating a cohesive theme of neural development and synapse formation, with one insect cuticle term as a potential outlier.","confidence":"High","size":27,"edges":145,"triangles":229,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":12},{"id":"GO:0043547","count":3},{"id":"GO:0030182","count":2},{"id":"GO:0000117","count":2},{"id":"GO:1902459","count":2}]},{"hash":"1973962257493389992","title":"Central metabolism and biosynthesis","description":"Most top GO terms are core metabolic and biosynthetic processes (TCA cycle, glycolytic process, oxaloacetate and amino acid catabolism, lysine-related pathways, porphyrinogen biosynthesis, and antibiotic biosynthetic process). This suggests the cluster centers on metabolic pathways and biosynthesis. Some terms like Notch signaling and DNA-templated transcription appear incidental and do not drive the main theme. ","confidence":"Medium","size":27,"edges":350,"triangles":2900,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0033512","count":11},{"id":"GO:0006099","count":9},{"id":"GO:0017000","count":9},{"id":"GO:0019878","count":8},{"id":"GO:0006351","count":7}]},{"hash":"2232972806682400326","title":"Complement activation and immune defense cluster","description":"The top GO terms cluster around complement pathways (classical and lectin), defense against Gram-positive bacteria, and leukocyte tethering/rolling, indicating a cohesive immune-defense module; other terms appear ancillary, suggesting some protein quality control or regulatory roles but not defining the main theme.","confidence":"Medium","size":27,"edges":128,"triangles":286,"max_degree":25,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0006469","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0097186","count":4}]},{"hash":"1665219996332630181","title":"MAPK signaling and RNA processing","description":"Cluster is enriched for MAPK pathway terms (ERK1/2 and p38 cascades) and multiple gene-expression processes, including transcription initiation, DNA-templated transcription, and RNA processing (splicing and polyadenylation), plus components linked to translation initiation and stimulus responses (PMA, GM-CSF). This suggests a cohesive module where MAPK signaling coordinates transcriptional and post-transcriptional regulation of gene expression.","confidence":"High","size":27,"edges":88,"triangles":58,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070371","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0006349","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0038066","count":3}]},{"hash":"1858630005269459740","title":"Immune signaling and cytoskeleton remodeling","description":"This cluster centers on immune-related signaling and cell movement: NK T cell differentiation, B cell affinity maturation, interleukin-7 response, and cellular migration, along with actin cytoskeleton organization and GTPase activity regulation. A few terms about insulin signaling appear, which may reflect metabolic-immune cross-talk, but the dominant pattern ties to immune cell signaling and cytoskeletal dynamics.","confidence":"Medium","size":27,"edges":26,"triangles":10,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0046626","count":3},{"id":"GO:0045737","count":3},{"id":"GO:0030036","count":3},{"id":"GO:1900026","count":3},{"id":"GO:0098761","count":3}]},{"hash":"1831280462770842726","title":"Transcription elongation and chromatin regulation","description":"The top GO terms cluster around transcription elongation (including positive regulation) and chromatin-associated processes such as histone ubiquitination, heterochromatin boundary formation, and transcription-coupled nucleotide-excision repair, suggesting a coherent theme of gene-expression control via chromatin state. Some terms point to neural contexts, which may reflect broader roles or annotation noise rather than a core theme of the cluster.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0001711","count":1},{"id":"GO:0006368","count":1},{"id":"GO:0010390","count":1},{"id":"GO:0019827","count":1}]},{"hash":"1337596590171566796","title":"Neural development and ion transport","description":"The cluster shows enrichment for ion transmembrane transport (sodium, potassium, calcium) and neural development terms (cerebellar granule cell differentiation, anterior lateral line development), along with neural signaling/behavior terms (serotonin metabolism, social behavior, forward locomotion). This pattern suggests proteins involved in neural differentiation and neuronal ion homeostasis, with related signaling and behavioral outputs. Some terms (chlorate/fungicide response) are peripheral, but do not override the central neural theme.","confidence":"High","size":27,"edges":52,"triangles":41,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0021707","count":5},{"id":"GO:0042428","count":4},{"id":"GO:0035176","count":4}]},{"hash":"2200111868403774284","title":"Angiogenesis and Immune Response","description":"The cluster shows enrichment for processes related to blood vessel growth and regulation (angiogenesis, angiotensin maturation), along with immune functions (adaptive immune response, antigen processing/presentation via MHC I, leukotriene biosynthesis) and cell signaling. Some terms hint at host-pathogen interaction (symbiont entry into host cell, ectodomain proteolysis). This combination suggests a functional group centered on vascular-immune coordination.","confidence":"Medium","size":27,"edges":3,"triangles":0,"max_degree":2,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0045766","count":5},{"id":"GO:0007267","count":4},{"id":"GO:0006509","count":4},{"id":"GO:0030154","count":4},{"id":"GO:0002005","count":4}]},{"hash":"682689303510798119","title":"Neural Ion Transport and Synaptic Plasticity","description":"The dominant GO terms are sodium, potassium, and calcium ion transmembrane transport, together with long-term synaptic depression, pointing to ion-channel\u2013driven neuronal signaling and plasticity. Additional terms for locomotion, suckling, social behavior, and lateral line development suggest neural circuits governing behavior in a sensory, possibly aquatic, organism. Overall, the cluster likely comprises ion channels/transporters and synaptic regulators shaping neural activity and behavior.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035725","count":8},{"id":"GO:0071805","count":8},{"id":"GO:0060292","count":8},{"id":"GO:0001967","count":8},{"id":"GO:0035176","count":7}]},{"hash":"1689800599842384370","title":"Development and ER-stress\u2013induced apoptosis","description":"The cluster includes strong developmental signals (multicellular organism development, neuron projection development, skeletal and skin development) plus transcriptional regulation and apoptosis-related terms, particularly intrinsic and ER stress\u2013induced apoptotic pathways, as well as ER-associated degradation. This points to proteins involved in development that are also engaged in cellular stress responses leading to apoptosis, linking developmental programs with ER stress and protein quality control.","confidence":"Medium","size":27,"edges":5,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:2001235","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0031175","count":5},{"id":"GO:0001501","count":5}]},{"hash":"1460467082199952833","title":"Angiogenesis and Skeletal Development","description":"The cluster is dominated by GO terms for angiogenesis, chondrocyte/bone development, and Wnt signaling regulation, pointing to a developmental program governing blood vessel and skeletal formation; a few immune or xenobiotic-related terms are present but appear secondary.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":5},{"id":"GO:0001501","count":4},{"id":"GO:0045766","count":4},{"id":"GO:0048240","count":4},{"id":"GO:0007275","count":4}]},{"hash":"1294000683133509373","title":"Signaling and transcription regulation","description":"This cluster shows a mix of GO terms tied to cell signaling (ephrin receptor signaling, angiotensin-mediated vasoconstriction), membrane-associated processes (protein transmembrane transport), and gene regulation (DNA-templated transcription, protein heterooligomerization, regulation of phosphorylation). The diversity suggests a broad network involved in signal transduction and transcriptional control rather than a single, unified function.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001822","count":4},{"id":"GO:0051291","count":4},{"id":"GO:0090180","count":3},{"id":"GO:1903212","count":3},{"id":"GO:2001172","count":3}]},{"hash":"617932818804219639","title":"RNA processing and translation initiation","description":"The terms cluster around RNA metabolism (splicing, polyadenylation, RNA modification) and translation control (preinitiation complex formation, translation reinitiation), indicating a group of proteins involved in RNA processing and regulation of translation.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":10},{"id":"GO:0002188","count":10},{"id":"GO:0006378","count":8},{"id":"GO:0045292","count":8},{"id":"GO:0075525","count":7}]},{"hash":"1048135482013978660","title":"Proteoglycan Biosynthesis and Cartilage Development","description":"The top GO terms emphasize dermatan/heparan/chondroitin sulfate proteoglycan metabolic processes and polysaccharide localization, plus a link to chondrocyte development, pointing to extracellular matrix proteoglycan assembly and cartilage biology. Although a transcription regulation term appears, the dominant signal is proteoglycan metabolism and ECM organization.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0033037","count":3},{"id":"GO:0050655","count":3},{"id":"GO:0015768","count":3},{"id":"GO:0030208","count":3}]},{"hash":"744258750875816699","title":"Developmental signaling and morphogenesis","description":"This cluster shows strong enrichment for developmental and signaling terms across multiple tissues, including nervous system development, axon guidance, Slit-Robo signaling, Hedgehog/Smoothened signaling, and ERK cascade activation, along with organogenesis processes like ossification and kidney development. The convergence on developmental signaling pathways and morphogenesis across neural and non-neural contexts supports a unified theme of coordinated tissue formation. ","confidence":"High","size":27,"edges":218,"triangles":752,"max_degree":23,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":19},{"id":"GO:0035385","count":19},{"id":"GO:0043931","count":18},{"id":"GO:0001822","count":18},{"id":"GO:0007224","count":18}]},{"hash":"2205910992812267542","title":"Sensory organ and nervous system development","description":"Most terms cluster around developmental patterning and organogenesis\u2014segment specification, CNS formation, antennal and compound eye development, and muscle development\u2014with regulatory notes on Wnt signaling. A few terms appear unrelated (metabolic regulation), likely noise. Overall, the cluster reflects developmental programs governing sensory organ and neural tissue formation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090180","count":1},{"id":"GO:0007379","count":1},{"id":"GO:2001172","count":1},{"id":"GO:0021556","count":1},{"id":"GO:0048749","count":1}]},{"hash":"487229744906119566","title":"Plant carbohydrate and lipid biosynthesis with rRNA maturation","description":"The top GO terms cluster around sugar and lipid biosynthesis (trehalose, glycogen, UDP-GlcNAc, sulfolipids) and also include ribosomal RNA maturation steps, with a hint of plant-specific processes like pollen development. This combination suggests a plant-centered cluster tied to metabolic biosynthesis and chloroplast-associated ribosome maturation, rather than a single narrow function, making this label a reasonable, though not perfect, summary.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005992","count":3},{"id":"GO:0005978","count":3},{"id":"GO:0000463","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0051568","count":2}]},{"hash":"2048995735438817898","title":"Transcription Regulation and Cell Cycle Control","description":"The protein set shows a clear enrichment for transcription-related GO terms (negative regulation of transcription by RNA polymerase II, DNA-templated transcription, transcription regulation by galactose) together with cell cycle processes (G1/S transition of the mitotic cell cycle, mitotic spindle pole separation). This points to a core theme of transcriptional control linked to cell cycle progression, with some broader developmental signaling annotations (Wnt signaling, mammary gland alveolus development) that may reflect additional roles. Overall, the dominant signal is transcription regulation intertwined with cell cycle control.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0060749","count":4},{"id":"GO:0007603","count":4},{"id":"GO:0042053","count":4}]},{"hash":"1842303154209272015","title":"Membrane trafficking and cytoskeletal remodeling","description":"This cluster centers on endomembrane transport (plasma membrane to endosome), cytoskeletal dynamics (filopodium and spindle-related processes, dendrite development), and neuronal connectivity activities (synaptic vesicle exocytosis, cell polarity), suggesting a shared theme of trafficking coupled to cytoskeletal remodeling that supports neurite outgrowth and polarity. Some cell cycle terms are present, but the dominant signal is trafficking and cytoskeletal organization related to neuronal morphology.","confidence":"Medium","size":27,"edges":54,"triangles":24,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048227","count":5},{"id":"GO:0007049","count":4},{"id":"GO:0033028","count":4},{"id":"GO:0043525","count":4},{"id":"GO:0090307","count":4}]},{"hash":"1645778730533336813","title":"Retroviral Entry, Integration, and Latency","description":"The top GO terms are dominated by retroviral processes: viral penetration into the host nucleus, establishment of integrated proviral latency, and DNA integration, which together point to proteins involved in retroviral infection and genome integration. Some additional terms relate to host-symbiont interactions, supporting a host-pathogen interaction theme, though a few metabolic terms appear unrelated. Overall, the cluster seems best described by retroviral entry and genome integration activities.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0046718","count":2}]},{"hash":"2283862049246895417","title":"Neuronal signaling and endocytic pathways","description":"The cluster features terms tied to neural functions (memory, grooming behavior) and neuromuscular signaling (acetylcholine-gated channel clustering), along with key signaling pathways (BMP and Wnt) and receptor-mediated endocytosis related to cholesterol transport. This combination points to a core theme of neural signaling linked to membrane trafficking and endocytic processes, with ancillary detoxification roles. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0007154","count":3},{"id":"GO:0090118","count":3},{"id":"GO:0007613","count":3}]},{"hash":"1778206724418522738","title":"Neural development and synaptic plasticity","description":"Most top GO terms describe neural development and synaptic processes (axonal fasciculation, synapse assembly, LTP/LTD), along with myelination and sensory organ morphogenesis (otolith). This points to proteins involved in brain wiring, neural signaling, and sensory system development as the cluster's core. Some terms like innate immune response or angiogenesis are less central to this theme but may reflect pleiotropy.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016525","count":5},{"id":"GO:0007413","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0014068","count":5},{"id":"GO:0035176","count":5}]},{"hash":"2165078710298507400","title":"Unknown","description":"The GO terms span musculoskeletal development, neural signaling, sensory perception, circadian regulation, and prostaglandin biosynthesis with no clear unifying function; edges and node connectivity are absent, suggesting no cohesive cluster function. ","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048630","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0050910","count":3},{"id":"GO:0001964","count":3},{"id":"GO:0098703","count":3}]},{"hash":"1510283563964633606","title":"Unknown","description":"The top GO terms are diverse, spanning development (lung development), neural processes (locomotion, dendrite morphogenesis, response to morphine), stress and protein handling (unfolded protein response, ER-Golgi transport, histone dephosphorylation), signaling (glucocorticoid pathway), and basic DNA replication. There isn\u2019t a single cohesive biological function uniting these terms, suggesting the cluster reflects a mix of unrelated activities rather than a distinct common theme.","confidence":"","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030324","count":6},{"id":"GO:0043278","count":6},{"id":"GO:0016576","count":6},{"id":"GO:0010288","count":6},{"id":"GO:0031987","count":6}]},{"hash":"351120358023469142","title":"RNA Pol II transcription regulation and chromatin remodeling","description":"The terms cluster around RNA polymerase II transcription control, including negative regulation of transcription by RNAP II, preinitiation complex assembly, and its regulation. Chromatin-related processes such as histone acetylation and nucleosome dynamics support a chromatin remodeling theme that modulates transcription. Some terms reference development or signaling contexts (spermatid development, photomorphogenesis, Rho signaling), but the dominant theme is transcription regulation via chromatin state.","confidence":"High","size":26,"edges":9,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0043966","count":3},{"id":"GO:0051123","count":2},{"id":"GO:0030466","count":2},{"id":"GO:0042766","count":2}]},{"hash":"1050119723900370917","title":"RNA Splicing and Translation Regulation","description":"Proteins in this cluster are enriched for RNA processing and translation control: spliceosome-mediated mRNA splicing, stress-influenced mRNA stability, regulatory ncRNA\u2013mediated gene silencing, and initiation/reinitiation of translation (including viral contexts). This points to a cohesive role in post-transcriptional gene expression regulation spanning both RNA processing and translation initiation/reinitiation.","confidence":"High","size":26,"edges":6,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":12},{"id":"GO:0010610","count":12},{"id":"GO:0031047","count":11},{"id":"GO:0000398","count":10},{"id":"GO:1901407","count":10}]},{"hash":"1520787321825538234","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0006310","count":3},{"id":"GO:0090502","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1893893039266842859","title":"RNA and peptide methylation","description":"Most of the top GO terms cluster around methylation of RNA and peptides (RNA guanine-N7 methylation, tRNA methylation, rRNA methylation, and peptidyl-glutamine methylation), suggesting a cohesive function in methylation modifications. Other terms appear less connected and may reflect ancillary roles or noise. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0036265","count":6},{"id":"GO:0030488","count":5},{"id":"GO:0070476","count":4},{"id":"GO:0042220","count":4},{"id":"GO:0006596","count":4}]},{"hash":"1449579402788254866","title":"Neural development and cellular stress signaling","description":"This cluster centers on neural development themes (substantia nigra development; negative regulation of axonogenesis) and processes linked to intracellular signaling and trafficking (Rab signaling; protein transmembrane transport), complemented by cellular stress and redox/homeostasis responses (ER stress response; redox homeostasis). While there are also proliferation and vascular-related terms present, the strongest cohesive signal is neural development together with stress and trafficking pathways.","confidence":"Medium","size":26,"edges":167,"triangles":504,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008283","count":13},{"id":"GO:0055114","count":12},{"id":"GO:1903206","count":9},{"id":"GO:0021762","count":9},{"id":"GO:0032482","count":8}]},{"hash":"1572574372385253591","title":"Actin Cytoskeleton Remodeling and Muscle Development","description":"This cluster is dominated by actin-related processes: actin nucleation, filament polymerization, Arp2/3-mediated nucleation, and actin bundle assembly, plus skeletal muscle fiber development. These consistently point to cytoskeletal remodeling linked to muscle differentiation, with other terms being supportive signaling or immune-related aspects. ","confidence":"High","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0045010","count":5},{"id":"GO:0010801","count":5},{"id":"GO:0048741","count":5},{"id":"GO:0043065","count":4},{"id":"GO:0006468","count":4}]},{"hash":"228154348144142549","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":23,"triangles":4,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008363","count":7},{"id":"GO:0006469","count":6},{"id":"GO:0071374","count":5},{"id":"GO:1901621","count":5},{"id":"GO:0090084","count":5}]},{"hash":"2087966929907809619","title":"Embryonic development & organ morphogenesis","description":"The cluster centers on broad embryonic development and organ morphogenesis, with recurrent GO terms for transcriptional regulation by RNA polymerase II and multiple tissue-specific morphogenesis processes (midbrain, pancreas, skeletal, palate, digestive tract, ureteric bud, neural crest). This suggests a cohesive theme of developmental gene regulation coordinating organ formation.","confidence":"High","size":26,"edges":48,"triangles":14,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0001755","count":9},{"id":"GO:0006366","count":9},{"id":"GO:0030901","count":9},{"id":"GO:0031018","count":8}]},{"hash":"1687071764663360247","title":"Sphingolipid signaling in angiogenesis and inflammation","description":"This cluster\u2019s top GO terms are dominated by sphingolipid metabolism and signaling (sphingosine-1-phosphate receptor signaling, sphingoid catabolic and phytosphingosine metabolic processes, lipid phosphorylation) along with vascular development/angiogenesis and inflammatory response. Together, these terms suggest a module where sphingolipid pathways drive angiogenesis and inflammation; a cortisol biosynthesis term appears as an outlier and does not change the core theme.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:2000064","count":3},{"id":"GO:0003376","count":3},{"id":"GO:0042346","count":3},{"id":"GO:0046834","count":3},{"id":"GO:0046521","count":3}]},{"hash":"1696155426032600007","title":"Developmental Morphogenesis and Growth Signaling","description":"This cluster centers on broad developmental processes and growth regulation, with GO terms pointing to multicellular organism development, embryonic skeleton morphogenesis, cartilage condensation, and larval cuticle development. It also includes signals and transcriptional control related to growth and development (positive regulation of cell growth, DNA-templated transcription, Wnt signaling) and pathway components (collagen-activated signaling). A minor inflammatory signaling term (interleukin-1-mediated signaling) appears, but the dominant theme is developmental morphogenesis and growth regulation. Confidence: Medium","confidence":"","size":26,"edges":12,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030307","count":2},{"id":"GO:0008363","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0070498","count":2},{"id":"GO:0006351","count":2}]},{"hash":"772200564916794182","title":"Autophagy and protein turnover regulation","description":"The top GO terms show a focus on regulating autophagy, ubiquitin-dependent protein degradation, and modulation of protein processing/localization, suggesting the cluster centers on controlling protein homeostasis and turnover. Although some developmental terms appear, the dominant theme is regulation of protein turnover and quality control pathways.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010508","count":1},{"id":"GO:0090005","count":1},{"id":"GO:0010955","count":1},{"id":"GO:0090285","count":1},{"id":"GO:0010171","count":1}]},{"hash":"503787886363337911","title":"Embryonic organogenesis and neurodevelopment","description":"Most of the top GO terms relate to development and differentiation of nervous tissue (floor plate, oligodendrocyte fate, interneuron differentiation) and other organ systems (pancreas, lung, bronchiole), all within embryonic contexts. The recurring theme is tissue patterning and lineage specification during vertebrate development. Thus the cluster can be labeled as Embryonic organogenesis and neurodevelopment.","confidence":"Medium","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":16},{"id":"GO:0033504","count":12},{"id":"GO:0031018","count":12},{"id":"GO:0021530","count":12},{"id":"GO:0060163","count":12}]},{"hash":"2296326918745660917","title":"Multitissue Development and Signaling","description":"The terms point to broad developmental and signaling processes across tissues (muscle/skeletal development, neural development, organ induction) with ERK pathway involvement, plus some immune activation terms, suggesting a general cross-tissue developmental/response program rather than a single specific function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001759","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0045163","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0030277","count":2}]},{"hash":"1070453646569071634","title":"GPCR-driven cAMP/cGMP Signaling","description":"The top GO terms indicate GPCR signaling pathways (adenosine receptor signaling, receptor guanylyl cyclase signaling) and production of the second messengers cAMP and cGMP, plus related blue-light signaling and forskolin response, suggesting a cohesive cluster of GPCR-triggered signaling components that regulate transcription and cellular responses. Magnesium ion response appears as a peripheral note but does not define the core theme.","confidence":"High","size":26,"edges":93,"triangles":65,"max_degree":17,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0032026","count":14},{"id":"GO:1904322","count":10},{"id":"GO:0006355","count":10},{"id":"GO:0052565","count":10},{"id":"GO:0071880","count":10}]},{"hash":"888395953691721184","title":"Neuronal Ion Channels and Sensory Behavior","description":"The cluster centers on ion transmembrane transport (K+, Na+), calcium import, and GABA signaling, all core to neuronal signaling and excitability, as reflected by EPSPs and startle/locomotor behavior. The inclusion of sensory-related GO terms (sound detection, conditioned taste aversion) plus circadian regulation suggests a cohesive theme of neuron-based sensory processing and behavioral responses. ","confidence":"High","size":26,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":15},{"id":"GO:0045188","count":14},{"id":"GO:0098703","count":14},{"id":"GO:0001964","count":14},{"id":"GO:0007214","count":11}]},{"hash":"1750860171437032362","title":"Steroid signaling and male reproductive development","description":"The cluster shows multiple GO terms tied to steroid hormone signaling, including steroid hormone receptor complex assembly, male sex differentiation, and prostate gland development, suggesting a core theme around steroid-driven reproductive development. The other metabolic terms (oxidation-reduction, methane/methanol metabolism, cholesterol metabolism) may reflect broader metabolic roles or annotation noise, but do not override the clear steroid-reproductive signal. Confidence: Medium","confidence":"","size":26,"edges":7,"triangles":3,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0046188","count":7},{"id":"GO:0019285","count":7},{"id":"GO:0015945","count":7},{"id":"GO:0008203","count":7}]},{"hash":"1772406566535167492","title":"Embryonic development and tissue morphogenesis","description":"Most terms cluster around developmental processes, including endocrine system development, organogenesis (cartilage morphogenesis, palate development, left-right pattern formation), and EMT in heart cushion formation. This suggests a cohesive theme of embryonic morphogenesis and tissue differentiation, with a few splicing/ transcription regulation terms likely reflecting gene-expression control during development. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":16},{"id":"GO:0003198","count":16},{"id":"GO:0060536","count":16},{"id":"GO:0060806","count":16},{"id":"GO:0060972","count":16}]},{"hash":"13530175861734276","title":"MAPK-driven transcriptional response","description":"Top GO terms indicate strong enrichment for ERK1/ERK2 and p38MAPK signaling cascades converging on DNA-templated transcription, with supporting terms for stimulus-responsive signaling and immune-related transcriptional programs. While cholesterol biosynthesis and nuclear transport regulation appear as minor notes, the core theme is MAPK signaling guiding transcriptional changes in response to stimuli. Confidence: Medium","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:1904628","count":6},{"id":"GO:0070371","count":6},{"id":"GO:0050830","count":6},{"id":"GO:0009636","count":6}]},{"hash":"113839065940530195","title":"Unknown","description":"The GO terms are highly heterogeneous, covering ribosome export, cell cycle, Hedgehog signaling, neural development, spermatogenesis, immune responses, CNS development, melanocyte migration, and complement activation, with no clear single theme tying all proteins together. This suggests no cohesive cluster function can be assigned.","confidence":"","size":26,"edges":5,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000055","count":5},{"id":"GO:0007049","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0031175","count":4},{"id":"GO:0030382","count":4}]},{"hash":"1362085346391502004","title":"Muscle cytoskeleton assembly and adhesion","description":"These terms emphasize cytoskeletal assembly and muscle-specific structures (sarcomeres, focal adhesions, microspikes, terminal web) and processes controlling muscle contraction and adaptation. A couple of terms (mitotic spindle assembly, ascospore formation) are more general cytoskeletal processes seen in other contexts, but the dominant signal points to muscle cytoskeleton organization and adhesion.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0090307","count":6},{"id":"GO:0030437","count":6},{"id":"GO:1902896","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0048041","count":4}]},{"hash":"745000584656421369","title":"Unknown","description":"The terms span DNA replication/integration (nuclear), plant plasmodesma/cell wall processes, and animal growth, signaling, and adhesion, with no clear unifying function across proteins. Therefore no coherent label can be assigned.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":7},{"id":"GO:0006261","count":3},{"id":"GO:0009663","count":2},{"id":"GO:2001009","count":2},{"id":"GO:0009831","count":2}]},{"hash":"1555252078895899241","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000186","count":2},{"id":"GO:0032836","count":2},{"id":"GO:0060070","count":2},{"id":"GO:0048539","count":1},{"id":"GO:0060444","count":1}]},{"hash":"1636910454682221633","title":"Plant cell wall biosynthesis and plasmodesmata organization","description":"The cluster is dominated by plant-specific processes: plasmodesma organization, regulation of plant-type cell wall cellulose biosynthesis, and plant-type cell wall modification linked to growth. Glycosylation-related terms also appear, supporting a cell wall/post-translational modification theme. Some terms like brain segmentation and apoptosis are less central and may reflect broader or incidental annotations, but the core signal points to plant cell wall construction and plasmodesmatal regulation.","confidence":"High","size":26,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0009663","count":4},{"id":"GO:2001009","count":4},{"id":"GO:0009831","count":4},{"id":"GO:0006486","count":4},{"id":"GO:0071555","count":3}]},{"hash":"704854320345595082","title":"DNA Damage Response and p53-Mediated Apoptosis","description":"The top GO terms include intrinsic apoptotic signaling by p53, apoptotic process, DNA repair, chromosome segregation, and DNA-templated transcription, which together point to a coordinated DNA damage response and genome maintenance pathway. Although translation and some metabolic processes appear among the terms, the recurrent emphasis on p53-driven apoptosis and DNA repair suggests the proteins function together in stress responses and cell-cycle governance rather than a single metabolic route. Therefore, the name reflects the strongest shared theme with reasonable specificity.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0001890","count":3},{"id":"GO:0072332","count":2},{"id":"GO:0007059","count":2},{"id":"GO:0006281","count":2}]},{"hash":"1079561280460089440","title":"Insect circadian rhythm and neural signaling with cuticle development","description":"The Top Terms include circadian sleep/wake regulation, sleep, cholinergic synaptic transmission, and tracheal tube diameter, along with chitin-based cuticle biosynthesis and secretory pathway processes (ER to Golgi transport and glycosylation). This combination suggests a cluster of insect proteins involved in neural signaling linked to circadian/sleep regulation and epidermal development (cuticle and trachea), mediated by secretory pathway components. Confidence: Medium","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0045187","count":2},{"id":"GO:0035158","count":2},{"id":"GO:1903818","count":2},{"id":"GO:0032222","count":2}]},{"hash":"1465905057199510728","title":"Unknown","description":"The top terms span telomere maintenance, epithelial polarity, proteasome assembly, cold response, chemokine production, Wnt signaling, cardiac action potential regulation, foam cell differentiation, and NOD2 signaling, with no single unifying process. Because the GO terms are diverse and do not point to a cohesive function for this cluster, there isn\u2019t a clear, representative label beyond Unknown.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904357","count":5},{"id":"GO:0090162","count":5},{"id":"GO:0070682","count":5},{"id":"GO:0009409","count":5},{"id":"GO:0071651","count":5}]},{"hash":"1179733266488497289","title":"Neuronal development and excitatory synaptic signaling","description":"The cluster\u2019s top GO terms cluster around nervous system development, glutamatergic synaptic transmission, excitatory postsynaptic potentials, and regulation of synaptic vesicle exocytosis, with additional emphasis on ERK signaling. This points to a shared role in neural development and excitatory synaptic communication, despite some obsolescent terms in the list.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010796","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0043552","count":4},{"id":"GO:0031384","count":4},{"id":"GO:2000300","count":4}]},{"hash":"94333720380474979","title":"Ubiquitin-Dependent Protein Regulation","description":"This cluster is dominated by ubiquitination-related GO terms (ubiquitin-dependent protein catabolic process, K33-linked ubiquitination, and regulation of ubiquitination), suggesting a core theme of protein turnover and regulation via ubiquitin pathways. The presence of muscle and kidney development terms may reflect ubiquitin\u2019s broad roles in development and signaling, with B cell receptor signaling appearing as a related regulatory context. Overall, the ubiquitin-centric processes appear to be the most coherent thread tying the terms together.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":20},{"id":"GO:0042787","count":19},{"id":"GO:2000312","count":19},{"id":"GO:1990390","count":19},{"id":"GO:0031397","count":19}]},{"hash":"1124148260924885969","title":"Unknown","description":"The Top Terms span very diverse functions (inflammation/chemokine signaling, carbohydrate metabolism, RNA modification, muscle/sarcomere organization, GI epithelium maintenance, neural development, ion channel clustering), and there are no edges or shared processes linking them. This lack of a cohesive theme means a single, representative function label cannot be confidently assigned.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090197","count":3},{"id":"GO:0005975","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0006032","count":2},{"id":"GO:0002143","count":1}]},{"hash":"1446181647100601048","title":"Embryonic organogenesis and neural crest morphogenesis","description":"The GO terms point to embryonic development across multiple tissues\u2014neural crest cell migration, cartilage formation, pancreas and midbrain/forebrain development, cochlea morphogenesis, ureteric bud branching, and digestive tract morphogenesis\u2014with accompanying transcriptional regulation, suggesting a cohesive theme of embryonic organogenesis and neural crest\u2013driven morphogenesis.","confidence":"High","size":25,"edges":9,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0001755","count":10},{"id":"GO:0051216","count":8},{"id":"GO:0031018","count":8},{"id":"GO:0090190","count":8}]},{"hash":"311741276748023180","title":"Developmental morphogenesis and immune signaling","description":"Top GO terms span organ morphogenesis (kidney tubule development, cartilage condensation, lymphatic vessel morphogenesis) and immune signaling pathways (complement lectin pathway activation, Fc-gamma receptor signaling, C-type lectin receptor signaling) plus NK cell chemotaxis regulation and stress-induced senescence, suggesting a cluster of proteins involved in tissue development with immune signaling roles.","confidence":"Medium","size":25,"edges":194,"triangles":687,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":23},{"id":"GO:0051873","count":23},{"id":"GO:0036303","count":23},{"id":"GO:0002223","count":23},{"id":"GO:0090403","count":23}]},{"hash":"2064603540898960773","title":"Core Metabolism and Ribosome Biogenesis","description":"The GO terms point to central metabolic pathways (pentose phosphate shunt, pentose biosynthesis, glyoxylate metabolism; phosphorylation; redox processes) along with energy production (mitochondrial electron transport) and fundamental growth machinery (ribosome biogenesis), plus basic ion transport. This suggests a cohesive cluster of housekeeping metabolic and biosynthetic processes tied to growth and energy. ","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006098","count":3},{"id":"GO:0019310","count":3},{"id":"GO:0000103","count":2}]},{"hash":"1745463214618979009","title":"Cerebellar neuronal differentiation and synaptic plasticity","description":"This cluster is dominated by GO terms related to neuronal development and synaptic function, notably cerebellar granule cell differentiation and regulation of both short- and long-term synaptic plasticity, plus receptor internalization. While a few terms (phototaxis, brown fat differentiation) are less related, the overall signal points to cerebellar/neural differentiation and synaptic regulation as the core theme of this cluster.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":4},{"id":"GO:0034115","count":3},{"id":"GO:0010739","count":3},{"id":"GO:0031623","count":3},{"id":"GO:0042331","count":3}]},{"hash":"591982175285954134","title":"Embryonic development and cell-cycle regulation","description":"The cluster is rich in embryogenesis and ectoderm/dorsal patterning terms (ectoderm development, embryonic body morphogenesis, positive regulation of dorsal identity, glial cell fate determination) alongside cell-cycle control (regulation of cell cycle, negative regulation of mitotic cell cycle, embryonic). Additional terms on adherens junctions and vesicle assembly align with tissue morphogenesis and cell adhesion in development, supporting a cohesive developmental theme.","confidence":"High","size":25,"edges":280,"triangles":1892,"max_degree":24,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0015991","count":16},{"id":"GO:0007050","count":15},{"id":"GO:0007398","count":14},{"id":"GO:0007403","count":14},{"id":"GO:0045976","count":14}]},{"hash":"1867996800364313920","title":"Unknown","description":"The top terms span diverse contexts, including insect cuticle development, antiviral/innate immune responses, myelination, collagen organization, and sensory structure morphogenesis, with no single dominant function or pathway tying the proteins together. This lack of a cohesive theme suggests the cluster cannot be meaningfully labeled with a specific biological function.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0051607","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0030199","count":1}]},{"hash":"770282208795709037","title":"Unknown","description":"The top GO terms are highly diverse, covering nucleolar rDNA maintenance, synaptic vesicle organization, neurotransmitter receptor internalization, NK cell degranulation, regulation of protein catabolic processes, meiotic chromosome condensation, NK T cell differentiation, tRNA gene clustering, meiotic cell cycle in oocytes, and amyloplast organization. There is no single coherent function or pathway linking these terms, indicating a mixed set of proteins without a common theme.","confidence":"","size":25,"edges":144,"triangles":550,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0043007","count":1},{"id":"GO:0099590","count":1},{"id":"GO:0048499","count":1},{"id":"GO:0043323","count":1},{"id":"GO:0042176","count":1}]},{"hash":"139029686643426324","title":"Embryonic development signaling and morphogenesis","description":"The terms are dominated by embryonic development and tissue morphogenesis (cranial skeleton, thyroid gland development, planar polarity) and developmental signaling pathways (MAPK cascade, ephrin signaling, PDGF response) with differentiation processes like brown fat cell differentiation. Some cell-cycle terms are present but do not override the overarching theme of developmental signaling networks guiding morphogenesis.","confidence":"High","size":25,"edges":226,"triangles":1052,"max_degree":23,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":25},{"id":"GO:0006260","count":25},{"id":"GO:0030878","count":23},{"id":"GO:0071507","count":23},{"id":"GO:0036120","count":23}]},{"hash":"52050778777427231","title":"Neural Development and Synapse Formation","description":"Most terms center on nervous system development, including synapse organization (GO:0050808), positive regulation of synapse assembly (GO:0051965), axonal fasciculation (GO:0007413), and myelination (GO:0042552). Collateral sprouting (GO:0048672) and otolith morphogenesis (GO:0032474) further tie to neural structure development and connectivity, suggesting a cluster of proteins involved in establishing and modifying neural connections. A few terms (innate immune response, proteolysis) are present but less representative, so the dominant theme is neural-synaptic processes.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:0050808","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0035234","count":3},{"id":"GO:0048672","count":3}]},{"hash":"2057277419211726820","title":"Growth Factor Signaling in Development","description":"The top GO terms cluster around receptor-initiated signaling pathways (PI3K activity, MAPK cascade, ephrin signaling, PDGF response) and development/differentiation processes (dendrite morphogenesis, brown fat cell differentiation, thyroid gland development), suggesting a cohesive module of growth factor\u2013driven signaling guiding development and cell fate.","confidence":"High","size":25,"edges":184,"triangles":900,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043552","count":20},{"id":"GO:0048813","count":20},{"id":"GO:0006813","count":20},{"id":"GO:0006351","count":20},{"id":"GO:0006935","count":20}]},{"hash":"359829504798182721","title":"Insect larval neural signaling and cuticle formation","description":"The dominant term is larval chitin-based cuticle development, suggesting roles in insect cuticle formation. The cluster also contains multiple neuronal signaling terms (GABA, acetylcholine, histamine) and sensory processing, pointing to neural signaling functions in insect larvae. Together these indicate a cohesive theme around insect larval neural signaling coupled with cuticle development.","confidence":"High","size":25,"edges":20,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":11},{"id":"GO:0017085","count":1},{"id":"GO:0045759","count":1},{"id":"GO:0042220","count":1},{"id":"GO:0050893","count":1}]},{"hash":"1857721442855991995","title":"Neural development and myelination","description":"The top GO terms cluster around nervous system development and connectivity\u2014myelination, axonal fasciculation, regulation of synapse assembly, and corpus callosum development\u2014suggesting these proteins function in neural development and neural network formation. A few non-neural terms appear but are less representative of the cluster\u2019s main theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0022038","count":2},{"id":"GO:0048681","count":2}]},{"hash":"1829305930471003787","title":"Embryonic organogenesis and skeletal morphogenesis","description":"The top GO terms point to broad embryonic development across various organs and structures, including cranial skeleton morphogenesis, heart development, nervous system development, kidney development, and palate formation, plus neuron migration and BMP signaling. This suggests the cluster groups proteins involved in early morphogenetic processes shaping multiple tissues, not a single tissue-specific function. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0007399","count":4},{"id":"GO:0048378","count":4},{"id":"GO:0030513","count":4}]},{"hash":"507861461344361198","title":"Neuronal signaling, touch perception, and ion transport","description":"This cluster centers on neural communication and mechanosensory processing, highlighted by terms for synaptic plasticity, excitatory postsynaptic potential, touch perception, locomotion, and ion channel transport (sodium and potassium). The inclusion of anterior lateral line development points to mechanosensory systems in aquatic organisms, reinforcing a theme of neuronal signaling coupled with ion transport. Some peripheral terms exist, but the core pattern fits neural signaling and touch sensing.","confidence":"High","size":25,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048169","count":5},{"id":"GO:0060079","count":5},{"id":"GO:0050975","count":5},{"id":"GO:0035176","count":4},{"id":"GO:0010157","count":4}]},{"hash":"1943456729108466483","title":"Sensory Ion Channels and Thermoregulation","description":"Top GO terms indicate sensory perception (pain, touch) and responses to temperature, including cold and diet-induced thermogenesis, along with membrane ion transport (sodium import, potassium export). This combination suggests proteins that function as or regulate ion channels involved in sensory signaling and thermoregulatory pathways in multicellular organisms. Therefore, a label focusing on sensory ion channel activity and thermoregulation best captures the cluster's core function.","confidence":"High","size":25,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":6},{"id":"GO:0098719","count":6},{"id":"GO:0097623","count":6},{"id":"GO:0007275","count":5},{"id":"GO:0071502","count":5}]},{"hash":"1810596014218481636","title":"Neural development and behavior","description":"The top GO terms point to neural development (cerebellar granule cell differentiation, visual learning) and behavioral responses (ethanol, amphetamine, social behavior, serotonin metabolism). Ubiquitin-proteasome turnover terms suggest dynamic protein regulation common in synaptic and neuronal signaling. Taken together, this cluster seems to group genes involved in neural development and modulation of behavior, with protein turnover as a supporting mechanism.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0048149","count":3},{"id":"GO:0021707","count":3},{"id":"GO:0001975","count":3},{"id":"GO:0008542","count":3}]},{"hash":"491805189176509358","title":"ESCRT-Mediated Endosomal Vesicle Trafficking","description":"This cluster is dominated by GO terms related to endosomal transport, multivesicular body assembly, ubiquitin-dependent protein degradation via the MVB pathway, and ESCRT-dependent viral budding, pointing to a shared role in vesicle formation and trafficking. A couple of terms (trophoblast giant cell differentiation, hemopoiesis) are less clearly related but do not negate the main vesicle-trafficking theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":2},{"id":"GO:1903774","count":1},{"id":"GO:1904669","count":1},{"id":"GO:0043162","count":1},{"id":"GO:1902188","count":1}]},{"hash":"1054702567324385632","title":"Unknown","description":"The cluster has 25 proteins with no detected interactions (no edges, no triangles) and no GO terms provided to reveal a common function, so there is no identifiable shared theme to name confidently. ReCIPE re-addition alone does not establish functional coherence, hence the label Unknown.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"897476646032243396","title":"Growth and Metabolic Differentiation","description":"This cluster is enriched for translation, glycolytic metabolism, and mitochondrial protein import, indicating a core of biosynthetic and energy production activity. It also includes developmental and differentiation terms (cardiac fate specification, substantia nigra development, megakaryocyte differentiation) and cell-cycle progression (G0 to G1), suggesting these proteins coordinate metabolism with growth and lineage specification across tissues.","confidence":"Medium","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0045654","count":3},{"id":"GO:0043046","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0006096","count":2}]},{"hash":"305915981481045366","title":"Vertebrate development and organogenesis","description":"These proteins are enriched for developmental processes across multiple tissues (cartilage morphogenesis, left/right pattern formation, placenta and pancreatic cell development, endocrine system development). Although there are a few RNA processing terms, the predominant theme is vertebrate embryonic development and organogenesis, so the label reflects the common function of the cluster.","confidence":"High","size":25,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0032298","count":2},{"id":"GO:1903026","count":2},{"id":"GO:0060707","count":2}]},{"hash":"184340957012949239","title":"Unknown","description":"The top GO terms span amino acid catabolism, energy production, transcription/translation, and developmental processes, with no single dominant theme, so a cohesive label isn't supported.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0006574","count":3},{"id":"GO:0042773","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0000278","count":3}]},{"hash":"2068906839147828349","title":"Golgi Trafficking and Lipid Transport","description":"This cluster is dominated by GO terms related to the secretory pathway, including Golgi ribbon formation and ER-to-Golgi vesicle transport, along with lipoprotein transport, pointing to a core function in Golgi trafficking and lipid handling. Some terms (phototransduction, apoptotic cell clearance, vitamin B3 response) are less related and may reflect broader cellular roles or annotation noise, but the main signal is Golgi-associated transport with lipid involvement.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006675","count":2},{"id":"GO:0090161","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0042953","count":2},{"id":"GO:0007604","count":2}]},{"hash":"1207884045010796104","title":"Innate immunity and complement activation","description":"Based on GO terms, this cluster centers on innate immune responses and complement pathways, including responses to lipopolysaccharide, classical and lectin complement activation, and neutrophil-mediated antibacterial activity; plasminogen activation and endothelial barrier dynamics also appear, suggesting an inflammation/remodeling context. A few terms reference transcription regulation and development, but the dominant theme is innate immunity.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0032496","count":12},{"id":"GO:0009791","count":11},{"id":"GO:0071333","count":11},{"id":"GO:0001867","count":11}]},{"hash":"1232985772061073339","title":"Inflammatory and oxidative stress signaling","description":"The cluster is dominated by GO terms related to inflammatory responses (interleukin-1, TNF) and oxidative stress (hydrogen peroxide), plus Rac-mediated signaling, which together suggest a general theme of stress- and immune-related signaling. While there are outliers (taste perception, lipid homeostasis, development), the central pattern points to signaling in response to inflammatory and oxidative stress.","confidence":"Medium","size":25,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050909","count":3},{"id":"GO:0006890","count":3},{"id":"GO:0016601","count":3},{"id":"GO:0055091","count":3},{"id":"GO:0071347","count":3}]},{"hash":"790520350991629024","title":"Cardiac morphogenesis and signaling","description":"This cluster centers on heart development and related signaling pathways. Notable terms include cardiac right atrium morphogenesis and regulation of the secondary heart field by Notch signaling, along with Wnt signaling. Additional terms point to epithelial polarity, endothelial differentiation, and cell cycle control, all of which support a cohesive theme of signaling-driven cardiac morphogenesis and vascular development. Some apoptosis terms are present but appear less central to the main theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0090162","count":8},{"id":"GO:0016055","count":8},{"id":"GO:0003270","count":8},{"id":"GO:0007049","count":8},{"id":"GO:0003213","count":8}]},{"hash":"2211881605086093720","title":"Synaptic signaling and postsynaptic assembly","description":"Based on the top GO terms, this cluster is enriched for neuronal and synaptic functions: postsynaptic membrane assembly, retrograde trans-synaptic signaling, and neural development of the retina. The presence of amyloid precursor protein metabolic process and response to xenobiotic stimulus also aligns with neuronal signaling contexts. Some terms like osteoblast development and gibberellic acid signaling appear as noise or annotation cross-talk, but the dominant pattern ties to synaptic communication and neural maturation, justifying the label.","confidence":"High","size":25,"edges":298,"triangles":2254,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":12},{"id":"GO:0002087","count":11},{"id":"GO:0002076","count":11},{"id":"GO:0042136","count":8},{"id":"GO:0051593","count":8}]},{"hash":"916469115480147749","title":"Neuronal development and synaptic signaling","description":"This cluster is driven by GO terms emphasizing neural differentiation, axon extension/regeneration, synapse assembly, interneuron migration, and inhibitory synaptic regulation, with Robo signaling also tying to axon guidance. A few immune-related terms appear but the dominant pattern centers on neural development and connectivity.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0048691","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0021836","count":2}]},{"hash":"10602085742272878","title":"Membrane Protein Proteolysis and NFAT Signaling","description":"The GO terms are dominated by membrane-associated proteolysis (ectodomain, intracellular domain, and ER-to-cytosol proteolysis) and by positive regulation of the calcineurin-NFAT signaling cascade, suggesting a cohesive theme where proteolytic processing at membranes modulates NFAT-driven signaling. Some developmental terms appear but likely reflect broader roles of proteolysis in morphogenesis (cartilage development, left-right patterning, mesoderm development). ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:0050776","count":1},{"id":"GO:0006509","count":1},{"id":"GO:0070886","count":1},{"id":"GO:1904211","count":1}]},{"hash":"272171431054429929","title":"Platelet Activation, Coagulation, and Cell Adhesion Signaling","description":"Top GO terms show strong enrichment for blood coagulation, platelet biosynthetic processes, integrin-mediated signaling, and cell adhesion, pointing to platelet activation and coagulation pathways. Additional lipid biosynthesis and phospholipid-response terms align with membrane remodeling during coagulation. This combination suggests a cohesive theme around platelet-driven coagulation and adhesion signaling rather than a single enzyme-specific function.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070317","count":4},{"id":"GO:0007596","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0007155","count":3}]},{"hash":"680781233090901764","title":"Neuronal axon growth and signaling","description":"The top GO terms are dominated by neural-specific processes: axon extension, axonal fasciculation, and clustering of voltage-gated sodium channels, all central to neuronal development and axon maturation. While a few terms touch on general development or immune signaling, the strongest and most recurrent signals point to neuronal growth and axon-related signaling as the core theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0048675","count":4},{"id":"GO:2000391","count":4},{"id":"GO:0007413","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0090197","count":4}]},{"hash":"2224892421487406863","title":"Embryonic Development and Morphogenesis","description":"The GO terms cluster around key embryonic development and morphogenesis processes, including endocrine system development, epithelial-to-mesenchymal transitions in heart development, cartilage morphogenesis, placental and pancreatic cell development, and left-right patterning, suggesting a role in developmental regulation and tissue differentiation; a minor portion relates to ubiquitin-dependent protein catabolism, but the dominant theme is embryogenesis and morphogenesis.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":10},{"id":"GO:0003198","count":10},{"id":"GO:0060536","count":10},{"id":"GO:0060806","count":10},{"id":"GO:0060972","count":10}]},{"hash":"1500181517997248895","title":"Unknown","description":"The GO terms span cell cycle, RNA processing, proteostasis, and neural/immune responses, with no single unifying function. The strongest enrichment is cell cycle/division, but many terms diverge (pain response, oligodendrocyte differentiation, chemokine production), making it hard to assign a cohesive label.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":4},{"id":"GO:0048265","count":3},{"id":"GO:0048709","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0051301","count":3}]},{"hash":"729340728652550646","title":"Olfactory and Forebrain Neurodevelopment","description":"The terms cluster around nose/olfactory pit development, forebrain development, and anterior/posterior pattern specification, signaling a neurodevelopmental theme focused on olfactory and brain regions; GABA shunt/catabolic terms appear as secondary signals.","confidence":"High","size":24,"edges":150,"triangles":544,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0050821","count":5},{"id":"GO:0021983","count":5},{"id":"GO:0006540","count":5},{"id":"GO:0043584","count":5},{"id":"GO:0019544","count":5}]},{"hash":"1250140754794074532","title":"Immune signaling and tissue morphogenesis","description":"The top GO terms show a blend of immune signaling pathways (stimulatory C-type lectin receptor signaling; complement activation via the lectin pathway; Fc-gamma receptor signaling; NK cell chemotaxis regulation) together with developmental/morphogenesis terms (metanephric kidney development and tubule morphogenesis, lymph vessel morphogenesis, cartilage condensation). This suggests proteins involved in developmental processes that intersect with immune signaling, or dual roles in tissue morphogenesis and immune pathways. A concise label capturing both themes is therefore appropriate.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":18},{"id":"GO:0051873","count":18},{"id":"GO:0036303","count":18},{"id":"GO:0002223","count":18},{"id":"GO:0090403","count":18}]},{"hash":"203976058334398237","title":"Rho-regulated Cytoskeletal Signaling and Growth Regulation","description":"The top GO terms cluster around regulation of Rho-mediated signal transduction, cytoskeletal dynamics (stress fiber and podosome assembly), and growth-related signaling pathways (insulin and growth hormone receptor signaling). This points to a cohesive theme of signaling control over the cytoskeleton and growth responses, with neural plasticity terms appearing as broader contexts of structural remodeling. Therefore, a label emphasizing Rho-linked cytoskeletal signaling and growth regulation is appropriate.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:2001275","count":6},{"id":"GO:0007605","count":6},{"id":"GO:0051835","count":5},{"id":"GO:0046628","count":5}]},{"hash":"1839778052569840456","title":"Regulation of protein ubiquitination","description":"The top GO terms are dominated by ubiquitination-related processes: ubiquitin-dependent protein catabolic process, protein K33-linked ubiquitination, and negative regulation of protein ubiquitination. These strongly suggest a cluster centered on how ubiquitination is governed, with ancillary immune signaling connections (e.g., mast cell cytokine production, dendritic cell differentiation). Some terms appear regulatory or outliers, but the ubiquitination theme is the clear core.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032764","count":19},{"id":"GO:0042787","count":19},{"id":"GO:2000312","count":19},{"id":"GO:1904431","count":19},{"id":"GO:0045497","count":19}]},{"hash":"1168571137855499358","title":"Glutamatergic Synaptic Transmission and Plasticity","description":"The top GO terms converge on neuronal communication and synaptic function: excitatory postsynaptic potentials, glutamatergic transmission, receptor clustering, and visual learning, together with insulin receptor/PI3K-AKT signaling that modulates synaptic plasticity. Serotonin metabolism and sodium ion transport further support a neuronal signaling context. This suggests a cohesive theme of glutamatergic synaptic signaling and plasticity. Confidence: High","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0043113","count":3},{"id":"GO:0035249","count":3},{"id":"GO:0008542","count":3}]},{"hash":"1103453210220186800","title":"Embryonic tissue and neural fate specification","description":"These proteins cluster around developmental processes across multiple tissues (muscle, skeletal system, pancreas, bronchioles) and neural lineage decisions (retinal ganglion axon guidance; spinal cord neuron and oligodendrocyte fate), with transcriptional regulation as a common regulatory layer. This suggests a module coordinating embryonic development and broad lineage specification. ","confidence":"Medium","size":24,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0048706","count":4},{"id":"GO:0045617","count":4},{"id":"GO:0031290","count":4},{"id":"GO:0031018","count":4}]},{"hash":"813642365379261733","title":"Embryonic Development and Tissue Morphogenesis","description":"The top GO terms cluster around developmental and morphogenetic processes across tissues, including cartilage formation, left-right patterning, EMT in heart development, placental and pancreatic development, and sarcomere organization, indicating a general development/morphogenesis theme rather than a single pathway.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0060536","count":1},{"id":"GO:0060972","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0035270","count":1}]},{"hash":"1473375633629865673","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007584","count":2},{"id":"GO:0060770","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0006032","count":2}]},{"hash":"334745384981981275","title":"Neuronal development and behavior","description":"The top GO terms are centered on nervous system development and function\u2014cerebellar granule cell differentiation, anterior lateral line development, and various behaviors (suckling, conditioned taste aversion, social behavior, locomotion)\u2014with accompanying ion channel activity (potassium/sodium transmembrane transport). This suggests a cluster of proteins involved in neural differentiation and behavioral signaling rather than a single pathway.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":8},{"id":"GO:0021707","count":8},{"id":"GO:0001661","count":8},{"id":"GO:0001967","count":8},{"id":"GO:0035176","count":7}]},{"hash":"1867309342023024214","title":"Insect development, Toll signaling, and neurogenesis","description":"The top GO terms span larval cuticle (chitin-based) development, Toll pathway and antifungal/antibacterial peptide biosynthesis, and neurodevelopmental processes like motor neuron axon guidance and CNS formation, suggesting a cluster of proteins coordinating insect development with innate immunity and neural differentiation.","confidence":"Medium","size":24,"edges":54,"triangles":25,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":11},{"id":"GO:0006967","count":3},{"id":"GO:0031637","count":3},{"id":"GO:0008045","count":3},{"id":"GO:0021556","count":3}]},{"hash":"2138243097196256061","title":"Gene Expression and Energy Metabolism","description":"This cluster is dominated by core gene expression processes (translation, mRNA export, transcription) alongside energy-related metabolism (mitochondrial electron transport, complex III assembly, molybdenum cofactor biosynthesis). The combination suggests proteins involved in basic cellular machinery that are connected to metabolic capacity, with a few outliers (nitrogen fixation, antibiotic response) that reflect broader metabolic or stress-related roles. Overall, the theme ties together expression machinery with energy metabolism.","confidence":"Medium","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006406","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0009399","count":2},{"id":"GO:0034551","count":2}]},{"hash":"546611937684818243","title":"Cell-Surface Receptor Signaling and Trafficking","description":"The dominant GO term is cell surface receptor signaling, with additional signals for receptor internalization and receptor-mediated interactions, plus trafficking-related terms such as ER targeting and lysosome localization. While a couple of terms (dendritic cell activation, photoreceptor differentiation) are less representative, the cluster appears centered on membrane receptor signaling and associated trafficking processes.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007166","count":2},{"id":"GO:0006465","count":1},{"id":"GO:0045047","count":1},{"id":"GO:0071404","count":1},{"id":"GO:0046813","count":1}]},{"hash":"464311503341420151","title":"Stress-Responsive Transcription and DNA Repair","description":"Top GO terms cluster around transcription and DNA repair, with additional stress-response signals (cadmium, cisplatin) and RNA processing; the proteins likely participate in coordinating transcriptional regulation and genome maintenance under cellular stress rather than a single pathway.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0071276","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0072719","count":2},{"id":"GO:1902042","count":2}]},{"hash":"1837476327115636964","title":"Nuclear transport & NPC assembly","description":"This cluster is dominated by GO terms for moving molecules in and out of the nucleus and building the nuclear pore complex, including mRNA export, ribosomal protein import, and NLS-bearing protein import, with additional signals related to regulation of desumoylation and GTPase activity that may modulate transport processes.","confidence":"High","size":24,"edges":137,"triangles":443,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":7},{"id":"GO:0000060","count":7},{"id":"GO:0051292","count":7},{"id":"GO:0006610","count":7},{"id":"GO:0060188","count":7}]},{"hash":"1034183799087567003","title":"Ubiquitin-Mediated Immune Regulation","description":"Dominant signals are ubiquitin-related processes (ubiquitin-dependent protein catabolism, K33-linked ubiquitination) and immune signaling (B cell receptor pathway, IgE isotype regulation). This points to a theme of ubiquitin-modulated immune signaling, despite some noisy terms.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0050853","count":12},{"id":"GO:0032764","count":11},{"id":"GO:2000312","count":11},{"id":"GO:1904431","count":11}]},{"hash":"1662604415499934871","title":"Developmental and innate immune processes","description":"The Top Terms show strong signals for innate immune response (3) and neutrophil clearance (3), indicating immune-related function. In addition, multiple terms relate to multicellular organism development, including lung-associated mesenchyme development, uterus morphogenesis, and melanocyte migration; together these suggest a broader developmental program affecting multiple tissues. There are chromatin-related terms (nucleosome assembly, histone modifications) that often accompany transcriptional regulation during development and immune cell differentiation. The combination points to a cluster of proteins involved in development with concurrent immune system roles, rather than a single tightly focused function.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0097350","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0060484","count":3},{"id":"GO:0097324","count":3}]},{"hash":"1514331406363728609","title":"Cytoskeletal signaling and remodeling","description":"The top GO terms point to regulation of the actin cytoskeleton and signal transduction (Rho pathway, sarcomere organization, actin cortical patch localization, and mechanical stimulus response), which together indicate cytoskeletal remodeling and related signaling. Other terms touch on Wnt signaling, ubiquitination, and immune or neural development, suggesting the cluster centers on cytoskeletal dynamics integrated with broader signaling and cellular activation. Overall, the dominant theme is cytoskeletal regulation intertwined with signaling, with some peripheral immune/developmental associations.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0016055","count":3},{"id":"GO:1900042","count":3},{"id":"GO:0048549","count":3}]},{"hash":"1009788636204098787","title":"RNA processing and ribosome biogenesis","description":"This cluster is dominated by GO terms for mRNA splicing via spliceosome and multiple ribosome-related processes (ribosomal large subunit export, ribosomal biogenesis, formation of translation preinitiation complex, ribosome biogenesis). These point to shared roles in RNA maturation and protein synthesis machinery. Some terms touch on transcription and developmental signaling, but the strongest, recurring theme centers on RNA processing and ribosome assembly/translation readiness.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0000055","count":3},{"id":"GO:0042273","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0032933","count":2}]},{"hash":"45647946280184770","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":91,"triangles":214,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":24},{"id":"GO:0048701","count":21},{"id":"GO:0019079","count":14},{"id":"GO:0006310","count":12},{"id":"GO:0009432","count":12}]},{"hash":"303818674997335964","title":"RNA processing and translation initiation","description":"Based on the GO terms, the cluster shows enrichment for mRNA modification, splicing regulation, ncRNA-mediated gene silencing, regulatory RNA processes, and the formation of translation preinitiation complexes. Although there are a few terms tied to oocyte axis specification, the dominant theme centers on RNA processing and the control of translation, suggesting these proteins function together in RNA metabolism and translation initiation pathways.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007310","count":3},{"id":"GO:0075525","count":2},{"id":"GO:1901407","count":2},{"id":"GO:0006378","count":2},{"id":"GO:1902625","count":2}]},{"hash":"1841034331987707675","title":"Meiosis-Related Nuclear Chromosome Maintenance","description":"The Top Terms show a clear emphasis on nuclear processes during meiosis: meiotic chromosome condensation, regulation of meiotic cell cycle (oocyte maturation), and NLS-bearing protein import into the nucleus, alongside maintenance of rDNA and related nucleolar/nuclear functions. While some outlier terms (ceramide metabolism, proton transmembrane transport) exist, the core signals point to meiosis-associated nuclear/chromosome maintenance. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0006607","count":4},{"id":"GO:0015991","count":4},{"id":"GO:0043007","count":3},{"id":"GO:0000060","count":3}]},{"hash":"1089097200570546899","title":"Mitochondrial Translation Machinery","description":"Enrichment is driven by GO:0006412 (translation) and GO:0070125 (mitochondrial translational elongation), pointing to mitochondrial protein synthesis components as the core of this cluster. A few other terms (hormone biosynthesis, hypoxia response, ion transport) are present but less representative, so the central theme remains mitochondrial translation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0070125","count":2},{"id":"GO:0060736","count":2},{"id":"GO:0097050","count":2},{"id":"GO:0001666","count":2}]},{"hash":"1184931298229859359","title":"Developmental signaling and chromatin/RNA regulation","description":"The list of top GO terms spans regulatory signaling (insulin receptor signaling, Rho signaling, sodium transport regulation), developmental processes (heart development, dendritic spine development), and gene expression control via chromatin remodeling and RNA processing (snoRNP assembly, snoRNA localization, histone deacetylation). This combination suggests a cluster of proteins involved in coordinating development through signaling cues and transcriptional/gene-expression regulation rather than a single, cohesive pathway.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902499","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0010765","count":2},{"id":"GO:0061000","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1117114745254455049","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by GO terms for translation, translational initiation, and ribosome biogenesis, pointing to a core set of proteins involved in protein synthesis machinery. Other terms like fatty acid biosynthesis, phosphatidylinositol signaling, and neuronal development appear less consistently, suggesting broader cellular roles or annotation noise, but the primary signal supports a ribosome/translation focus.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006633","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0006413","count":2},{"id":"GO:0048015","count":2}]},{"hash":"672525853774439079","title":"Transmembrane transport of sugars and xenobiotics","description":"This cluster is dominated by GO terms for membrane transport of sugars and related metabolites (L-ascorbic acid and dehydroascorbic acid, D-glucose, D-xylose, sodium-dependent organic cation transport) and xenobiotic compounds, plus osmotic stress responses and epithelial maintenance. The shared theme is transporter activity across membranes for sugars, vitamins, and xenobiotics, with tissue-level regulatory cues relevant to transport processes.","confidence":"High","size":24,"edges":223,"triangles":1070,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0019852","count":24},{"id":"GO:0042908","count":24},{"id":"GO:0070837","count":24},{"id":"GO:0015753","count":24},{"id":"GO:0006970","count":24}]},{"hash":"738868258790178874","title":"Neural development and axon guidance via ERK signaling","description":"This cluster is dominated by GO terms tied to CNS development, neuron projection and axon guidance (branchiomotor and sympathetic neurons), synaptic plasticity regulation, and ERK/MAPK signaling (ERK1/ERK2 cascade). The convergence on neural development and signaling pathways, especially ephrin signaling and TGF-beta pathway regulation that influence guidance and synaptic modulation, supports a coherent theme of neuronal development and axon guidance mediated by MAPK signaling. Some terms like phagocytosis and angiogenesis appear tangential but can be linked through shared signaling networks, not undermining the primary neural-centric pattern.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000187","count":3},{"id":"GO:0007417","count":2},{"id":"GO:0006911","count":2},{"id":"GO:0030511","count":2},{"id":"GO:1901187","count":2}]},{"hash":"666898411815049597","title":"Glutamatergic synaptic signaling and drug response","description":"The top GO terms center on glutamatergic synaptic transmission, receptor clustering, and excitatory postsynaptic potentials, with additional clues from receptor tyrosine kinase signaling and axonal development, pointing to excitatory synapse signaling and connectivity. The inclusion of behavioral and drug-response terms (morphine, ethanol, amphetamine) suggests these proteins are involved in neural signaling tied to drug- and behavior-related responses, reinforcing a cohesive theme around glutamatergic synapses and their modulation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":5},{"id":"GO:0043113","count":4},{"id":"GO:0035249","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0014068","count":4}]},{"hash":"1154366294571168620","title":"Bacterial lipid and steroid biosynthesis with antibiotic response","description":"The cluster\u2019s top GO terms cluster around lipid and steroid biosynthesis (glucocorticoid biosynthetic process, C21-steroid hormone metabolic process, sphingolipid biosynthetic process, mycolic acid biosynthetic process, poly-hydroxybutyrate biosynthetic process) and antibiotic-related processes (antibiotic biosynthetic process, response to antibiotic), suggesting a cohesive theme of bacterial lipid/steroid metabolism with antimicrobial compound interactions. The presence of mycolic acid and sphingolipid pathways points toward cell envelope lipid metabolism in bacteria, while antibiotic-related terms indicate interplay with antimicrobial compounds. The obsolete oxidation-reduction term appears incidental to the core theme.","confidence":"High","size":24,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0017000","count":7},{"id":"GO:0046677","count":6},{"id":"GO:0042619","count":5},{"id":"GO:0006704","count":5}]},{"hash":"158778871781862861","title":"Neural development and tissue morphogenesis","description":"The top GO terms center on nervous system development and neural signaling (e.g., ERK cascade, Rac signaling), with morphogenesis and cell\u2013cell adhesion processes (adherens junction organization, hair follicle and gland formation). This pattern suggests proteins involved in neural development along with broader tissue morphogenesis, rather than a single tissue-specific role.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043525","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0060661","count":3},{"id":"GO:0031069","count":3}]},{"hash":"890211845838003654","title":"Nervous system development and synaptic maturation","description":"The top GO terms point to nervous system development, myelination, axon guidance, neurogenesis, and regulation of synaptic plasticity and synapse assembly. This suggests the proteins collectively participate in neural differentiation, connectivity formation, and maturation, including peripheral nervous system aspects. The cluster thus represents neural development and synaptic regulation rather than a single molecular pathway.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":7},{"id":"GO:0042552","count":6},{"id":"GO:0060292","count":6},{"id":"GO:0001525","count":5},{"id":"GO:0048172","count":5}]},{"hash":"751474570202843426","title":"Developmental signaling and transcription networks","description":"The proteins show enrichment in transcriptional regulation (DNA-templated transcription) and several development- and signaling-related processes (Wnt signaling, ephrin signaling regulation, synaptic plasticity regulation, cell migration, adipocyte differentiation). This suggests a broad network coordinating developmental signaling and transcription across tissues, rather than a single specific function.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:1901187","count":3},{"id":"GO:1900383","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0032212","count":3}]},{"hash":"1165436848118225832","title":"Developmental Signaling and Cell Cycle Regulation","description":"The top GO terms cluster around core cellular processes (mitotic cell cycle, DNA-templated transcription, apoptotic process) alongside multiple signaling pathways (canonical Wnt, Hippo, T cell receptor signaling) and responses (lipopolysaccharide). This pattern suggests a module of proteins that coordinate cell proliferation, differentiation, and immune-related signaling during development, rather than a single specialized function.","confidence":"Medium","size":23,"edges":147,"triangles":502,"max_degree":22,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":19},{"id":"GO:0007601","count":19},{"id":"GO:0033160","count":14},{"id":"GO:0090263","count":13},{"id":"GO:0050852","count":13}]},{"hash":"2085365973062702519","title":"Stress-Response Transcription and Apoptosis Signaling","description":"The cluster combines strong signals for DNA-templated transcription with multiple stress-related responses (nitric oxide, ER stress, cadmium), apoptosis execution and intrinsic signaling, and developmental pathways (hippo signaling, multicellular development), suggesting a theme of transcriptional regulation under stress that links to apoptosis and development. ","confidence":"Medium","size":23,"edges":31,"triangles":22,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0071732","count":5},{"id":"GO:0097194","count":5},{"id":"GO:0006935","count":5},{"id":"GO:0032436","count":5}]},{"hash":"2039819557730962097","title":"Larval chitin-based cuticle development","description":"The top GO term for the cluster is larval chitin-based cuticle development (GO:0008363), with all 23 proteins linked to this process, indicating the cluster collectively participates in chitin-containing cuticle formation during larval development. This provides a cohesive, specific functional theme for the group.","confidence":"High","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":23}]},{"hash":"1224859091315998901","title":"DNA Repair and Ubiquitin Regulation","description":"The cluster shows enrichment for DNA repair (GO:0006281) and multiple ubiquitin-related processes (histone H2A deubiquitination, K11-linked deubiquitination, deneddylation) plus COP9 signalosome assembly, pointing to a module of chromatin maintenance and ubiquitin regulation in the DNA damage response. Some terms also touch translation initiation regulation and exosomal secretion, but the core pattern centers on ubiquitin/nedd8 pathway regulation linked to genome maintenance.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006281","count":4},{"id":"GO:0035522","count":4},{"id":"GO:0010950","count":3},{"id":"GO:0010387","count":3},{"id":"GO:0014067","count":3}]},{"hash":"453550573899758013","title":"Broad developmental transcriptional regulation","description":"The cluster includes transcription-related GO terms (transcription by RNA polymerase II and its negative regulation) together with diverse developmental terms across multiple tissues and lineages (muscle, retina, thyroid, ureteric bud, habenula, spinal cord, forebrain). This combination points to a general role in coordinating gene expression programs during development rather than a single organ-specific pathway.","confidence":"Medium","size":23,"edges":199,"triangles":877,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:2000288","count":7},{"id":"GO:0090190","count":7},{"id":"GO:0021986","count":7},{"id":"GO:0060041","count":7}]},{"hash":"1140410001242974493","title":"Steroid and lipid biosynthesis cluster","description":"The top GO terms are dominated by biosynthetic processes for lipids and steroids\u2014glucocorticoid biosynthesis, C21-steroid hormone metabolic process, sphingolipid biosynthesis, mycolic acid biosynthesis, and poly-hydroxybutyrate biosynthesis\u2014plus related cofactors like tetrahydrobiopterin. This suggests the proteins in the cluster participate in diverse lipid and steroid metabolism pathways, with a few outlier terms (e.g., lung development, acetoin catabolism) that do not negate the overall theme.","confidence":"Medium","size":23,"edges":185,"triangles":726,"max_degree":21,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":22},{"id":"GO:0042619","count":20},{"id":"GO:0006704","count":19},{"id":"GO:0008207","count":19},{"id":"GO:0030148","count":19}]},{"hash":"783799593366666577","title":"GTPase-regulated cell migration and morphogenesis","description":"This cluster is dominated by GO terms tied to small GTPase signaling and regulation (e.g., small GTPase-mediated signal transduction; positive regulation of GTPase activity), which drive cytoskeletal remodeling and cell movement (cell migration, podosome assembly). Additional terms for PDGF signaling, calcium-dependent exocytosis, and branching/morphogenesis (mammary gland duct branching, neuron development) point to broader developmental processes where directed migration and signaling are key. Together, these terms suggest a cohesive theme of GTPase-driven migration and morphogenic signaling across cell types.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":3},{"id":"GO:0045736","count":3},{"id":"GO:0007264","count":2},{"id":"GO:0071803","count":2},{"id":"GO:0043547","count":2}]},{"hash":"2075533807339102428","title":"Cell cycle control and transcription regulation","description":"Top GO terms cluster around cell cycle control (cell cycle, cell division, protein localization to kinetochore) and transcriptional regulation (DNA-templated transcription, negative regulation of transcription by RNA Pol II), with supporting chromatin dynamics (nucleosome assembly) and translation initiation components (preinitiation complex formation, translation reinitiation). This suggests a module coordinating cell division with gene expression and chromatin remodeling.","confidence":"High","size":23,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0001731","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0045736","count":3}]},{"hash":"1695070374164674225","title":"Inflammation and barrier maintenance","description":"This cluster combines immune-related terms (production of molecular mediators in inflammatory response; positive regulation of chemokine production) with barrier and adhesion components (cell-matrix adhesion; septate junction assembly; establishment of glial blood-brain barrier). While there are also general processes like calcium transport and methylation, the recurring theme links inflammatory signaling to tissue barrier integrity, especially in neural-support contexts. Confidence: Medium","confidence":"Medium","size":23,"edges":29,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":2},{"id":"GO:0005975","count":1},{"id":"GO:0002532","count":1},{"id":"GO:0006032","count":1},{"id":"GO:0090197","count":1}]},{"hash":"871394894332264753","title":"Ribosome biogenesis and translation machinery","description":"Top GO terms are dominated by translation and ribosome-related processes: translation, cytoplasmic translation, formation of the translation preinitiation complex, translation reinitiation, mRNA export, and ribosome biogenesis. This points to proteins involved in ribosome assembly and the protein synthesis machinery. Some terms like regulatory ncRNA-mediated gene silencing and positive regulation of apoptosis appear less central to the main theme, suggesting additional regulatory links, but the core cluster clearly centers on translation and ribosome biogenesis.","confidence":"High","size":23,"edges":30,"triangles":7,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0006406","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0006412","count":3}]},{"hash":"1984185311302375954","title":"Neural Development and Axon Guidance","description":"This cluster is dominated by terms related to nervous system development, axon guidance, and ROBO (Roundabout) signaling, plus ERK cascade regulation, pointing to neuronal patterning and connectivity. While there are additional terms about cell division and trafficking, the strongest signals center on neural development and axon pathfinding.","confidence":"Medium","size":23,"edges":9,"triangles":0,"max_degree":3,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0043552","count":8},{"id":"GO:0043931","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0070374","count":8}]},{"hash":"1893449731375603194","title":"Neural development and synaptic signaling","description":"The top GO terms point to neural processes: sensory perception of touch, excitatory postsynaptic potential, and regulation of long-term synaptic plasticity, which together suggest a cluster of proteins involved in neuronal development and synaptic function. There are also indicators of broader development and cell-cycle activity, plus an insect-specific larval cuticle term, which may reflect annotations in insect nervous system development. Overall, the dominant theme is neural development and synaptic signaling.","confidence":"Medium","size":23,"edges":91,"triangles":88,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":5},{"id":"GO:0043278","count":2},{"id":"GO:0051291","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0000278","count":2}]},{"hash":"786849942642358055","title":"Chitin-based cuticle development","description":"Top GO terms point to body morphogenesis and, specifically, chitin-based cuticle development, suggesting the cluster centers on the formation of a chitin-containing cuticle during development. With no network edges and only two low-count annotations, the strongest shared theme is cuticle formation, making this label representative though the evidence is limited. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010171","count":1},{"id":"GO:0040003","count":1}]},{"hash":"2203186312865463595","title":"Cardiac transcriptional regulation and apoptosis signaling","description":"The top GO terms cluster around transcriptional regulation (RNA Pol II, DNA-templated transcription), ubiquitination, JNK signaling, apoptosis regulation, heart development, and NF-kB-related pathways, together suggesting a cardiac-specific transcriptional control theme linked to stress-induced apoptotic signaling. The combination of heart development and apoptotic regulation supports a coherent cardiac transcriptional/apoptotic cluster.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0046328","count":4},{"id":"GO:0016567","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1185064188606959045","title":"Embryonic and Organ Development","description":"The top GO terms cluster around development of diverse tissues and organs (forebrain, retina, pituitary, skeletal muscle, cranial skeleton, gonads) and broad multicellular organism development, with a regulatory term on transcription. This suggests the proteins act in developmental regulation and organogenesis rather than a single tissue-specific process.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0030900","count":7},{"id":"GO:0008584","count":6},{"id":"GO:0045617","count":6},{"id":"GO:0007275","count":6}]},{"hash":"40920549434289689","title":"Embryonic morphogenesis and organ development","description":"The GO terms point to embryonic development and organ formation, including cartilage morphogenesis, left/right patterning, placenta-related differentiation, and endocrine system development. The cluster appears to reflect developmental programs rather than mature tissue function.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":11},{"id":"GO:0060972","count":11},{"id":"GO:0060707","count":11},{"id":"GO:0035270","count":11},{"id":"GO:0060806","count":11}]},{"hash":"490197082300328567","title":"Cell Migration and Development Signaling","description":"The GO terms point to migratory and developmental processes across multiple tissues (neuron migration, mast cell chemotaxis, smooth muscle migration, myoblast differentiation, inner ear development) with signaling pathways like ERK/MAPK and PI3K supporting these processes. A few terms involve stress or antiviral responses (response to toxic substance, hypoxia, regulation of viral genome replication) that can modulate migration and development, but the central theme appears to be cell movement and tissue development signaling.","confidence":"Medium","size":23,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":2},{"id":"GO:0045071","count":2},{"id":"GO:0001764","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0043552","count":2}]},{"hash":"1122117608498730701","title":"RNA processing and translation regulation","description":"This cluster centers on RNA maturation and gene expression control, with terms for translation initiation/reinitiation, splicing (including spliceosome regulation and alternative splicing), mRNA export, and ncRNA-mediated silencing. Together they point to a cohesive module of mRNA processing and translation control mechanisms.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0001731","count":7},{"id":"GO:0002188","count":6},{"id":"GO:0006378","count":5},{"id":"GO:0031047","count":5},{"id":"GO:0048026","count":5}]},{"hash":"971514121633250600","title":"Neuronal Synaptic Signaling and Memory","description":"The top GO terms center on synaptic function (excitatory postsynaptic potential, regulation of synaptic vesicle endocytosis), calcium transport, and neural activity-related processes (response to amphetamine, long-term memory), with supporting neural-development terms (retina layer formation). This pattern suggests a cluster focused on neuronal signaling and memory/plasticity across brain and retina.","confidence":"High","size":23,"edges":49,"triangles":22,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0097274","count":10},{"id":"GO:0070542","count":7},{"id":"GO:0007616","count":7},{"id":"GO:0010842","count":7},{"id":"GO:0006816","count":7}]},{"hash":"1537899755662954926","title":"Neural and muscular development with synaptic signaling","description":"The top GO terms indicate broad developmental roles (multicellular organism development, heart development, Schwann cell development, myoblast fusion) alongside neural/muscular signaling (long-term synaptic potentiation, excitatory postsynaptic potential, response to muscle activity), suggesting a cluster of proteins involved in nervous and muscular system development and their synaptic function.","confidence":"High","size":23,"edges":39,"triangles":52,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":10},{"id":"GO:0000278","count":10},{"id":"GO:0007601","count":9},{"id":"GO:0007507","count":9},{"id":"GO:0014044","count":9}]},{"hash":"1789251517653750914","title":"Unknown","description":"The top GO terms span highly diverse processes (proteasome assembly and ubiquitin-dependent ERAD, Wnt signaling, vitamin D response, immune defense, telomere maintenance, glucose regulation, muscle stretch response, and cell migration) with no clear, single function tying the proteins together. This makes it unlikely that the cluster represents a cohesive, well-defined biological role, so an Unknown label is most appropriate.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0033280","count":5},{"id":"GO:0070682","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0016055","count":4},{"id":"GO:0050830","count":4}]},{"hash":"1878495639174793670","title":"Ubiquitin-Dependent Proteolysis and Histone Catabolism","description":"Proteins in this cluster are dominated by ubiquitin-mediated protein turnover terms (ubiquitin-dependent proteolysis, polyubiquitination, autoubiquitination) and histone catabolic processes, suggesting coordinated turnover of ubiquitinated substrates and chromatin components. The presence of apoptosis regulation and V(D)J recombination terms hints at broader roles in stress response and immune gene rearrangements that involve ubiquitin signaling. Overall, the main theme appears to be ubiquitination-driven protein degradation and histone turnover.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0051865","count":8},{"id":"GO:1903265","count":8},{"id":"GO:0085020","count":8},{"id":"GO:0036205","count":8}]},{"hash":"1177234383584780660","title":"Vertebrate neural and organ development","description":"The cluster includes GO terms covering brain development, neural crest migration, forebrain proliferation, and morphogenesis across several organs (cochlea, liver, palate, hair follicles), plus nervous system\u2013related regulation of behavior and respiration, pointing to a broad vertebrate developmental/morphogenetic theme rather than a single pathway.","confidence":"High","size":23,"edges":24,"triangles":0,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043524","count":6},{"id":"GO:0090103","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0001889","count":5},{"id":"GO:0060021","count":5}]},{"hash":"30292915517824474","title":"Ubiquitin-Dependent Immune Signaling and Apoptosis","description":"The dominant GO terms emphasize ubiquitin-mediated proteolysis alongside signaling pathways that control apoptosis and immune responses (NF-\u03baB activation, TNF signaling, autoubiquitination). Immune-related terms such as V(D)J recombination support an immune-context cluster, suggesting a core role in ubiquitin-proteasome regulation linked to cell survival and inflammation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0042981","count":10},{"id":"GO:0090073","count":10},{"id":"GO:2000620","count":10},{"id":"GO:0033151","count":10}]},{"hash":"596609351046394806","title":"Glutamatergic synapse assembly and receptor clustering","description":"Top terms are dominated by synaptic organization and glutamate receptor clustering (synapse assembly; NMDA/AMPA receptor clustering; long-term potentiation), indicating the cluster centers on assembling glutamatergic synapses and organizing receptor complexes. Some terms like apoptosis and heterochromatin formation may reflect broader cellular annotations rather than core function.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007416","count":11},{"id":"GO:0006915","count":11},{"id":"GO:0006348","count":10},{"id":"GO:1900273","count":10},{"id":"GO:0034260","count":10}]},{"hash":"1815876266048036338","title":"Gene Expression Regulation and Signaling","description":"This cluster is anchored by regulation of gene expression (translation and transcription) and by signaling pathways (MAPK, PDGF) involved in growth and development, with additional links to cell cycle and DNA damage response via kinetochore localization.","confidence":"Medium","size":23,"edges":8,"triangles":1,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034501","count":6},{"id":"GO:0006977","count":4},{"id":"GO:0006412","count":4},{"id":"GO:0045727","count":4},{"id":"GO:0031290","count":4}]},{"hash":"307265890468192979","title":"Unknown","description":"The top terms are a mix of developmental signaling (Notch regulation, coronary artery morphogenesis, axon guidance), general proteolysis and ion homeostasis, and diverse metabolic processes (lipopolysaccharide biosynthesis, epoxygenase P450 pathway). This combination does not point to a single coherent function for the cluster, suggesting heterogeneous or cross-species annotations rather than a unified biological role.","confidence":"","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0045746","count":5},{"id":"GO:0009103","count":4},{"id":"GO:0060982","count":4},{"id":"GO:0048846","count":4}]},{"hash":"1795289092676452668","title":"Neuronal differentiation and ubiquitin regulation","description":"The dominant non-obsolete terms point to neural development (neuron differentiation; neuron apoptotic processes) and regulation of the ubiquitin system (positive regulation of ubiquitin-protein transferase activity; negative regulation of ubiquitin-dependent protein catabolic process). This suggests a cluster focused on neural differentiation with emphasis on protein homeostasis via ubiquitin signaling. Some terms are obsolete, but the core theme remains neural development combined with ubiquitin-mediated regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031064","count":1},{"id":"GO:0030182","count":1},{"id":"GO:1901407","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0000117","count":1}]},{"hash":"1119141995270738337","title":"DNA Repair and Recombination","description":"The cluster shows strong enrichment for DNA recombination and repair processes (base-excision repair, double-strand break repair via synthesis-dependent strand annealing, general DNA replication, SOS response, gamma radiation response) and includes meiotic recombination and somatic hypermutation terms, indicating a cohesive function in genome maintenance and mutation-driven processes.","confidence":"High","size":23,"edges":99,"triangles":142,"max_degree":17,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":5},{"id":"GO:0006284","count":5},{"id":"GO:0045003","count":4},{"id":"GO:0007131","count":4},{"id":"GO:0009432","count":4}]},{"hash":"1393666517920178400","title":"Retroviral entry and proviral latency","description":"This cluster centers on steps of the retroviral life cycle and host interaction: RNA-templated DNA biosynthesis (reverse transcription), DNA replication, DNA integration, viral penetration into the host nucleus, and establishment of integrated proviral latency. Supporting terms indicate host-pathogen dynamics and defense modulation (negative regulation of siRNA processing, symbiont-related apoptosis) and broader host cell entry processes, suggesting a cohesive theme of viral genome integration and host entry/latency with related cellular responses.","confidence":"High","size":23,"edges":26,"triangles":4,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:0006278","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0075713","count":3}]},{"hash":"316889930388342759","title":"Developmental signaling and growth","description":"The cluster's top GO terms are dominated by developmental processes (spermatid development, nervous system development, ossification, multicellular organism growth) and signaling (positive regulation of ERK cascade, cell spreading), suggesting proteins that coordinate tissue development and signal transduction. A few innate immune terms appear but are less representative, indicating a primary developmental/signal theme.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":4},{"id":"GO:0043552","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0045087","count":3}]},{"hash":"310462062575259035","title":"GPCR signaling in visual and pain pathways","description":"This cluster\u2019s top GO terms cluster around GPCR-mediated signaling with connections to vision (visual perception, regulation of opsin signaling) and somatosensory modulation (responses to morphine/amphetamine, regulation of sensory perception of pain, prepulse inhibition), plus GPCR internalization and possible regulation of GTPase activity. Together they suggest proteins involved in GPCR-driven signaling in visual and nociceptive pathways, with some entries touching on receptor trafficking and neural processing. An outlier term related to cell wall macromolecule catabolic process appears unrelated to this theme.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":2},{"id":"GO:0051930","count":2},{"id":"GO:0060134","count":2},{"id":"GO:0001975","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1535416603374738322","title":"Proteoglycan biosynthesis and metabolism","description":"The top GO terms cluster around proteoglycans and their glycosaminoglycan side chains (dermatan sulfate, heparan sulfate, chondroitin sulfate), including proteoglycan metabolic processes and polysaccharide localization, with links to development processes such as chondrocyte development and ureteric bud formation. This suggests a cohesive function in extracellular matrix composition and biosynthesis of proteoglycans.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033037","count":2},{"id":"GO:0050655","count":2},{"id":"GO:0015768","count":2},{"id":"GO:0030208","count":2},{"id":"GO:0030202","count":2}]},{"hash":"2243142436508441557","title":"Angiogenesis and hematopoietic signaling (Kit)","description":"These proteins show enrichment for angiogenesis, KIT signaling, and hematopoietic cytokine production (IL-2, IL-3, GM-CSF) as well as megakaryocyte development, indicating a coordinated role in blood vessel formation and blood cell lineage development. While a CNS development term appears, it is less central to the core theme. Overall, the Kit pathway\u2013driven angiopoietic/hematopoietic signaling best unifies these terms.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":5},{"id":"GO:0007417","count":3},{"id":"GO:0000187","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0045401","count":3}]},{"hash":"255481817444430715","title":"Inner ear and vestibular development","description":"The top GO terms cluster around semicircular canal morphogenesis, vestibular reflexes, and cartilage development, all pointing to formation and function of the inner ear's vestibular system. A few other terms (e.g., endoderm formation, osteoblast regulation) appear as noise, but the dominant signal is inner ear/vestibular development.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048752","count":2},{"id":"GO:0060030","count":2},{"id":"GO:0051216","count":2},{"id":"GO:0060005","count":1},{"id":"GO:0032765","count":1}]},{"hash":"1720414697442476035","title":"Cardiac Development and Heart Function","description":"The GO terms show a clear emphasis on heart development and physiology, including sinoatrial node development, heart rate regulation, heart contraction, and vascular remodeling in the coronary system. Ischemia response fits the cardiac stress context, and while a couple terms touch on unrelated processes (skin barrier, endocytic recycling), the dominant signal is cardiovascular development and function.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002931","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0061436","count":1},{"id":"GO:0060047","count":1},{"id":"GO:0003201","count":1}]},{"hash":"1215412212231058847","title":"Lipid Catabolism and Detoxification","description":"The top GO terms cluster around breakdown and turnover of lipids (triglycerides, monoacylglycerols, phosphatidylserine, chlorophyll) and lipid signaling (endocannabinoid regulation), complemented by detoxification and oxidative stress responses. This suggests proteins involved in lipid catabolic pathways and related membrane remodeling that mitigate toxic or oxidative challenges. While some terms are plant-specific (chlorophyll), the overarching theme is lipid degradation and lipid-mediated signaling with detox outcomes.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":5},{"id":"GO:0008360","count":3},{"id":"GO:0006486","count":3},{"id":"GO:0098869","count":2},{"id":"GO:0009636","count":2}]},{"hash":"2029375392534255152","title":"Innate Immune Signaling","description":"Top terms center on antiviral defense and innate immunity, especially defense response to virus, innate immune response, and MyD88-dependent Toll-like receptor signaling. The additional terms suggest broader developmental and extracellular matrix roles, but the dominant theme across the cluster is innate immune signaling, indicating a cohesive biological explanation for these proteins' annotation. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051607","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0042552","count":4},{"id":"GO:0030199","count":3},{"id":"GO:0051770","count":3}]},{"hash":"1104356397696562710","title":"Ubiquitin-mediated regulation of cell cycle","description":"Top GO terms indicate a focus on ubiquitination (monoubiquitination, autoubiquitination, ubiquitin-dependent proteolysis, and K63-linked ubiquitination) and protein turnover, alongside mitosis-related processes (mitotic nuclear membrane reassembly, nuclear pore complex assembly). This suggests a cohesive theme of ubiquitin-driven regulation of protein fate during cell division, with ancillary links to immune signaling. Confidence: Medium","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0030579","count":2},{"id":"GO:0006513","count":2},{"id":"GO:0051865","count":2}]},{"hash":"415662302255708299","title":"Ubiquitin-Proteasome-Mediated Degradation","description":"This cluster is dominated by ubiquitination-related processes: ubiquitin-dependent protein catabolism, K48- and K63-linked ubiquitination, SCF-dependent proteasomal degradation, protein autoubiquitination, ERAD, and sumoylation, all pointing to ubiquitin-proteasome\u2013driven protein turnover. A peroxisome import term is present but does not define the main function.","confidence":"High","size":22,"edges":144,"triangles":448,"max_degree":21,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":16},{"id":"GO:0051865","count":14},{"id":"GO:0042787","count":11},{"id":"GO:0016558","count":10},{"id":"GO:0051092","count":10}]},{"hash":"1046989681042654175","title":"Nucleotide Biosynthesis and DNA Replication","description":"The cluster is enriched for nucleotide-related processes\u2014AMP biosynthetic process, nucleoside metabolic process, and 5-phosphoribose 1-diphosphate biosynthetic process\u2014alongside cell division and viral genome replication, which together point to a core theme of nucleotide metabolism linked to DNA replication and proliferation. Phosphorylation suggests regulation of these activities. Some terms (nervous system development, fungal-type cell wall organization) appear less directly related and may reflect broader annotations or noise, but do not override the main nucleotide/DNA replication signal.","confidence":"Medium","size":22,"edges":134,"triangles":363,"max_degree":19,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0019079","count":5},{"id":"GO:0006167","count":5},{"id":"GO:0016310","count":5},{"id":"GO:0034418","count":5}]},{"hash":"1169110001816525515","title":"Neural development and glutamatergic signaling","description":"Top terms point to neural development and function\u2014cerebellar granule cell differentiation, lateral line development, and locomotion\u2014with a strong emphasis on glutamatergic synaptic transmission and ion channel\u2013mediated transport.","confidence":"Medium","size":22,"edges":39,"triangles":34,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":6},{"id":"GO:0021707","count":6},{"id":"GO:0035249","count":6},{"id":"GO:0035176","count":5},{"id":"GO:0010157","count":5}]},{"hash":"2247306064888912518","title":"Ribosome Biogenesis and Translation","description":"The cluster is strongly enriched for ribosome-related processes: translation (GO:0006412), maturation of rRNA (GO:0000462, GO:0000463, GO:0000466), ribosome biogenesis (GO:0042254), and small subunit assembly (GO:0000028). This points to proteins involved in ribosome production and protein synthesis. Peripheral terms like lipid tube assembly and apoptotic process are less central to the core function but may reflect broader roles or coincident processes. Confidence: High","confidence":"","size":22,"edges":50,"triangles":81,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0000462","count":6},{"id":"GO:0042254","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0000466","count":3}]},{"hash":"1251879831696327639","title":"Developmental signaling and cytoskeletal regulation","description":"This cluster shows enrichment for development-related processes (multicellular organism development, skin development) and regulatory terms tied to signaling and cytoskeletal dynamics (positive regulation of protein autophosphorylation and peptidyl-tyrosine phosphorylation, Rho GTPase activity, and Arp2/3-mediated actin nucleation), suggesting a cohesive theme of developmental signaling coupled to cytoskeletal remodeling. Some terms like mRNA transport and hypoxia response appear peripheral, but the dominant signal aligns with development and cytoskeletal control.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030433","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0031954","count":6},{"id":"GO:0050731","count":6},{"id":"GO:2000601","count":6}]},{"hash":"1382819781736636548","title":"Ubiquitin-regulated protein turnover","description":"This cluster is dominated by GO terms for ubiquitination and deubiquitination (including K63- and K33-linked deubiquitination), and associations with ubiquitin-dependent protein catabolic processes and regulation of apoptosis/DNA damage response. These suggest a cohesive theme around ubiquitin signaling controlling protein stability and cell fate, with a few additional terms (e.g., chloroplast mRNA modification, otic vesicle morphogenesis) that may reflect broader or context-specific roles in the dataset. ","confidence":"High","size":22,"edges":40,"triangles":45,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0046832","count":2},{"id":"GO:0071947","count":2},{"id":"GO:1900871","count":2},{"id":"GO:0070536","count":2},{"id":"GO:0016567","count":2}]},{"hash":"1945344637689333714","title":"Neurodevelopment and Synaptic Plasticity","description":"This cluster is strongly enriched for neuronal development and synaptic function, including neuron development, Schwann cell development, visual perception, and long-term potentiation, which together point to neural formation and synaptic plasticity. Angiogenesis aligns with neurovascular development, and positive regulation of peptidyl-threonine phosphorylation suggests signaling pathways that modulate neuronal activity. A couple of terms (mitotic cell cycle and ABA-activated signaling) seem less directly related and may reflect broader cellular processes or annotation artifacts, but they do not override the dominant neural theme. Overall, the cluster can be labeled \"Neurodevelopment and Synaptic Plasticity\" with a high level of representativeness.","confidence":"High","size":22,"edges":27,"triangles":11,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000086","count":9},{"id":"GO:0000278","count":9},{"id":"GO:0043065","count":9},{"id":"GO:0009738","count":9},{"id":"GO:0060291","count":9}]},{"hash":"1016611703803314345","title":"Innate and adaptive immune regulation via ubiquitination","description":"The terms point to regulation of innate immune signaling (complement activation, negative regulation of TLR5 and NOD1 pathways) and adaptive immunity (B cell homeostasis, LPS tolerance), tied together by ubiquitin-mediated protein modification (ubiquitination and deubiquitination). This suggests a cluster of proteins that modulate immune responses rather than execute them.","confidence":"High","size":22,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":2},{"id":"GO:0034148","count":1},{"id":"GO:0070429","count":1},{"id":"GO:1902042","count":1},{"id":"GO:0071947","count":1}]},{"hash":"345512997148990716","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0008363","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0071035","count":1},{"id":"GO:0034476","count":1}]},{"hash":"1947036330586520351","title":"Proteoglycan Metabolism and ECM Development","description":"Top GO terms indicate glycosaminoglycan proteoglycans (dermatan sulfate, heparan sulfate, chondroitin sulfate) metabolism and localization, pointing to extracellular matrix roles, with development-associated terms (chondrocyte development, ureteric bud formation) supporting a morphogenesis function.","confidence":"High","size":22,"edges":78,"triangles":127,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0033037","count":2},{"id":"GO:0050655","count":2},{"id":"GO:0015768","count":2},{"id":"GO:0030208","count":2},{"id":"GO:0030202","count":2}]},{"hash":"89934524947630850","title":"Insect larval cuticle development","description":"The strongest signal is larval chitin-based cuticle development, pointing to insect-specific cuticle formation during larval stages. Supporting terms include mesoderm formation and DNA-templated transcription/DNA replication, suggesting broad developmental and cell-growth processes. Additional terms related to redox homeostasis, apoptosis, and hormone signaling hint at regulatory remodeling during development. Overall, the cluster seems centered on insect larval development with cuticle biosynthesis and associated cellular processes, though the terms span both specialized and general functions.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008363","count":10},{"id":"GO:0045454","count":3},{"id":"GO:0001707","count":3},{"id":"GO:0006260","count":3},{"id":"GO:1901621","count":3}]},{"hash":"492196387413369646","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":14,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007218","count":2},{"id":"GO:0071374","count":2},{"id":"GO:1901621","count":2},{"id":"GO:0090084","count":2},{"id":"GO:0006458","count":2}]},{"hash":"375496222226080911","title":"Chromatin regulation and heterochromatin formation","description":"The top GO terms are centered on chromatin state control, including negative regulation of chromatin silencing at telomeres, heterochromatin formation, and histone deacetylation. This points to an overarching theme of chromatin regulation and epigenetic modification, even though several terms are obsolete or represent outliers (e.g., biofilm formation, neural development). The absence of edges suggests a loose grouping, but the recurring chromatin-related terms support a chromatin regulation theme. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031939","count":3},{"id":"GO:0061408","count":3},{"id":"GO:0061186","count":3},{"id":"GO:0061188","count":3},{"id":"GO:0043709","count":2}]},{"hash":"800496799094747939","title":"Neural development and sensory perception","description":"The top GO terms point to neural development and sensory functions, with brain development, neural crest cell migration, and visual perception all represented. While some terms are more general (protein folding, transcription regulation) or obsolete, the prominent themes cluster around neural development and sensory processes, suggesting this reflects a group of proteins tied to nervous system formation and vision. The lack of edges in the network implies the annotation-derived signal may reflect shared functions or co-expression rather than direct interactions, so the label aims to capture the core theme rather than exact molecular connectivity.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045723","count":2},{"id":"GO:0043087","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0006457","count":2},{"id":"GO:0001755","count":2}]},{"hash":"134648148991758426","title":"Neuronal development and ion channel clustering","description":"This cluster centers on nervous system development and the organization of neuronal connections, including synapse assembly, nerve impulse transmission, and the clustering of voltage-gated potassium and sodium channels, as well as paranode axon localization. While a single term references myoblast fusion, the dominant signals reflect CNS development and ion-channel\u2013mediated connectivity.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":18},{"id":"GO:0045163","count":16},{"id":"GO:0019226","count":16},{"id":"GO:0007520","count":16},{"id":"GO:0007399","count":16}]},{"hash":"898135182811174653","title":"Neural development and axon guidance","description":"The top GO terms are dominated by neural development and axon guidance processes\u2014olfactory lobe development, axon extension/regeneration, axonal fasciculation, and planar polarity\u2014suggesting a coherent theme of neural morphogenesis. Immune-related terms are present but appear as secondary signals, not defining the primary function of the cluster. Therefore, labeling with a neural development focus is most representative.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0090197","count":5},{"id":"GO:0001798","count":5},{"id":"GO:0021988","count":4},{"id":"GO:0060445","count":4},{"id":"GO:0048691","count":4}]},{"hash":"619548764360169435","title":"Unknown","description":"The GO terms span immune signaling (B cell receptor, Fc receptor regulation), development in neural and reproductive tissues, apoptosis, and IP3 signaling, with no single unifying function. The lack of network connectivity further suggests no cohesive cluster label can be assigned.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":3},{"id":"GO:0048666","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0060065","count":3},{"id":"GO:0006915","count":3}]},{"hash":"1541372836557341365","title":"Developmental Morphogenesis and Vesicle Trafficking","description":"The top GO terms predominantly point to developmental processes (in utero embryonic development, lung connective tissue development, nipple morphogenesis) and vesicle trafficking/regulation (ER to Golgi vesicle-mediated transport, regulation of GTPase activity, ion transport, Wnt receptor turnover, ubiquitin-mediated proteolysis). This suggests a cluster of proteins linked to tissue morphogenesis with roles in membrane trafficking and protein turnover, though the connections are not tightly cohesive (no edges). ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902953","count":3},{"id":"GO:0001701","count":3},{"id":"GO:0060427","count":3},{"id":"GO:0060658","count":3},{"id":"GO:0043547","count":2}]},{"hash":"165394674980162468","title":"Neurodevelopment and sensory organ morphogenesis","description":"The top GO terms cluster around nervous system development, inner and outer ear morphogenesis, and planar polarity, indicating a developmental program governing neural and sensory tissue formation. While there are immune-related terms present (e.g., B cell receptor signaling, dendritic cell cytokine production), the strongest shared signal is developmental biology focused on neural and sensory organs rather than immune function.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0050853","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0043552","count":2},{"id":"GO:0001736","count":2}]},{"hash":"1909732845987843660","title":"Unknown","description":"The GO terms are too diverse to reveal a single cohesive function for the cluster: metabolic regulation (thiamine biosynthesis, glycolytic fermentation), autophagy, development and polarity processes, neuron maturation, actin remodeling, chromatin localization, and immune signaling, with no edges connecting the proteins. This lack of a common theme justifies an Unknown label.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090180","count":4},{"id":"GO:1903212","count":4},{"id":"GO:2001172","count":4},{"id":"GO:0016239","count":2},{"id":"GO:0007527","count":2}]},{"hash":"525570729232521739","title":"Cytokine-Driven Inflammatory Signaling","description":"The top GO terms are dominated by inflammatory and cytokine signaling processes (positive regulation of chemokine production; production of mediators in inflammatory response; cellular response to interleukin-1; response to interleukin-6; activation of NF-kappaB-inducing kinase activity), indicating a cluster of proteins involved in cytokine-mediated inflammation. Some terms related to development or chitin are likely ancillary or context-specific, but the strongest signal points to inflammatory signaling pathways.  ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090197","count":3},{"id":"GO:0021707","count":3},{"id":"GO:0006032","count":2},{"id":"GO:0007250","count":2},{"id":"GO:0030324","count":2}]},{"hash":"191815454734000507","title":"Xenobiotic and Ion Transmembrane Transporters","description":"These proteins are strongly enriched for transmembrane transport of xenobiotics, vitamins, and a variety of ions and small molecules (phosphate, nitrate/nitrite, sodium/potassium, galactose, etc.), suggesting a cohesive group of membrane transporters with broad substrate specificity.","confidence":"High","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":21},{"id":"GO:0035461","count":21},{"id":"GO:0042891","count":17},{"id":"GO:1900754","count":14},{"id":"GO:0035435","count":14}]},{"hash":"307989095216653535","title":"Proteoglycan and Glycosaminoglycan Biosynthesis","description":"The cluster is dominated by GO terms for biosynthesis of proteoglycans and glycosaminoglycans, including heparan sulfate and dermatan sulfate proteoglycans, as well as related matrix/ECM organization processes. Although some terms are plant-specific or obsolete, the common thread is extracellular polysaccharide and proteoglycan assembly, suggesting a cohesive role in proteoglycan/GAG biosynthesis and ECM formation.","confidence":"Medium","size":22,"edges":198,"triangles":1051,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0006049","count":6},{"id":"GO:0035010","count":6},{"id":"GO:0035284","count":6},{"id":"GO:0006486","count":6},{"id":"GO:0010417","count":3}]},{"hash":"1683607543555804746","title":"Chemosensory and environmental signaling cluster","description":"Top GO terms include chemosensory behavior and detection of carbon dioxide, along with responses to caffeine and insecticide, plus signals related to ERK1/ERK2 cascade regulation, defense against bacteria, and symbiont entry into host cells. This mix points to a theme of sensing environmental cues and transducing signals that can influence behavior, development, and host interactions. While the proteins may participate in diverse processes, the common thread is environmental sensing and downstream signaling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":2},{"id":"GO:0042742","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0031000","count":1}]},{"hash":"360733990244068838","title":"Oxidant detoxification and prostaglandin biosynthesis","description":"This cluster is enriched for cellular oxidant detoxification and prostaglandin biosynthetic processes, with additional signals of estradiol response, xenobiotic catabolism, and immune/hormonal signaling, suggesting a module focused on oxidative defense and lipid mediator production rather than a single, narrow pathway.","confidence":"Medium","size":22,"edges":230,"triangles":1520,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":16},{"id":"GO:0001516","count":14},{"id":"GO:2000255","count":13},{"id":"GO:0032355","count":12},{"id":"GO:0071460","count":12}]},{"hash":"1439806574051093027","title":"Epithelial Polarity and Endocytosis Signaling","description":"The cluster is enriched for GO terms about establishing and maintaining epithelial cell polarity, endocytosis, and associated signaling pathways (ephrin receptor signaling and Wnt signaling). Additional terms related to GTPase regulation, podosome/actin dynamics, and cell adhesion point to coordinated control of membrane trafficking, cytoskeletal remodeling, and cell shape in polarized epithelial contexts. Overall, the proteins likely participate in polarity-driven endocytic trafficking and adhesion signaling rather than a single enzymatic pathway.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":5},{"id":"GO:0090162","count":4},{"id":"GO:0048013","count":4},{"id":"GO:0034260","count":4},{"id":"GO:0071803","count":4}]},{"hash":"1532107903723002677","title":"Ion transport and locomotion in fish","description":"This cluster centers on ion transport across membranes (sodium, potassium, magnesium) and movement/sensory functions (startle response, forward locomotion, lateral line development), pointing to neuromuscular signaling and sensory-m motor processes in fish. Some unrelated terms appear, but the dominant terms support a fish ion-channel/movement theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001964","count":2},{"id":"GO:0015693","count":1},{"id":"GO:0002377","count":1},{"id":"GO:0035176","count":1},{"id":"GO:0010157","count":1}]},{"hash":"939384621915285245","title":"Ubiquitin-Dependent Immune Regulation","description":"The cluster shows a prominent pattern of ubiquitination-related processes (ubiquitin-dependent protein catabolic process, various forms of ubiquitination, and regulation of protein ubiquitination) alongside immune-related functions (mast cell cytokine production, dendritic cell differentiation, and IgE isotype switching), suggesting coordinated roles in protein turnover and modulation of immune signaling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032764","count":20},{"id":"GO:0042787","count":20},{"id":"GO:2000312","count":20},{"id":"GO:1904431","count":20},{"id":"GO:0045497","count":20}]},{"hash":"314235155341443534","title":"Membrane transporters for nutrients and ions","description":"The cluster is dominated by transmembrane transport GO terms covering a wide range of substrates (4-hydroxyphenylacetate, L-ascorbic acid/dehydroascorbic acid, D-xylose, phosphate, nitrate, sodium, potassium, xenobiotics) plus an osmotic stress response term. This points to a cohesive set of membrane transport proteins facilitating uptake/export of diverse nutrients and ions and supporting osmotic adaptation. Confidence: High","confidence":"High","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":22},{"id":"GO:0019852","count":22},{"id":"GO:0042908","count":22},{"id":"GO:0070837","count":22},{"id":"GO:0015753","count":22}]},{"hash":"614166160505674711","title":"Embryonic development and organ morphogenesis","description":"The GO terms cluster around diverse organogenesis and patterning processes (cartilage morphogenesis, left-right patterning, mesoderm and placenta-related development, palate and hair follicle morphogenesis, endocrine system development, pancreatic cell development), indicating a cohesive theme of embryonic development and tissue morphogenesis.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0007498","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0010957","count":2}]},{"hash":"2219769075712627649","title":"Unknown","description":"The terms span telomere maintenance, lineage development, RNA/DNA metabolism, and general metabolic processes with no single dominant function tying all proteins together, making a cohesive, specific label unreliable.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061820","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0000335","count":2},{"id":"GO:0006203","count":2}]},{"hash":"568122146146579762","title":"Organ development and tissue differentiation","description":"The top GO terms point to broad developmental processes across tissues\u2014organ induction, multicellular organism development, kidney development, neural development (neuron migration, ventricular zone division), and GI epithelium maintenance\u2014supported by signaling (ERK cascade) and maturation elements (sarcomere organization, channel clustering). This suggests the cluster centers on developmental programs and tissue differentiation rather than a single tissue-specific function.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001759","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0045163","count":2}]},{"hash":"571875204234015162","title":"Ubiquitin-Dependent Regulation of Cellular Processes","description":"The strongest annotation is ubiquitin-dependent protein catabolic process, present for 8 proteins, with additional terms spanning immune defense, circadian rhythm regulation, DNA replication initiation, and meiosis spindle assembly. This pattern suggests a cohesive role for ubiquitin-mediated control influencing proteostasis and signaling across diverse cellular pathways (cell cycle, immunity, circadian rhythm), rather than a single linear function. The lack of edges indicates the clustering is based on shared GO annotations rather than direct interactions.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0071276","count":5},{"id":"GO:0042752","count":5},{"id":"GO:0051607","count":4},{"id":"GO:0045087","count":4}]},{"hash":"413688077417947330","title":"Diverse membrane transport of nutrients and ions","description":"This cluster shows strong enrichment for transmembrane transport of a wide range of substrates, including phosphate, nitrate, sodium, potassium, D-xylose, L-ascorbic acid and dehydroascorbic acid, and xenobiotics. The osmotic stress response term further supports a role in membrane-based transport and osmotic regulation. Overall, the proteins likely function together as diverse nutrient and ion transporters or transporter-associated proteins.","confidence":"High","size":21,"edges":155,"triangles":658,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0035435","count":8},{"id":"GO:1900754","count":7},{"id":"GO:0019852","count":7},{"id":"GO:0042908","count":7},{"id":"GO:0070837","count":7}]},{"hash":"30924211195336510","title":"Neural differentiation and development","description":"The top GO terms are dominated by neural-related processes (substantia nigra development, neuron differentiation, negative regulation of dendrite morphogenesis), indicating a brain/neuron-directed program. Additional terms fit neural progenitor biology and differentiation support, such as DNA replication and cell cycle (reflecting proliferating progenitors), and ER-Golgi vesicle transport (essential for neurite extension and protein trafficking). Regulatory signals like TGF-beta receptor signaling and GTPase activity further modulate differentiation and morphogenesis. While some terms point to broader differentiation contexts (e.g., lung epithelial differentiation), the strongest signal centers on neural development, making this label representative.","confidence":"High","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0021762","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0030512","count":3},{"id":"GO:0030182","count":3}]},{"hash":"1334928766012249329","title":"Nervous system development and GABAergic signaling","description":"The GO terms are dominated by nervous system related processes (brain development, nervous system development, sensory perception of sound) and GABAergic synaptic transmission, with supportive hints of neuronal trafficking and apoptosis. This suggests proteins clustered around neural development and synaptic function, justifying a label centered on nervous system development and GABAergic signaling.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007605","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0006888","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0007018","count":4}]},{"hash":"1256544935319164841","title":"Immune signaling and tissue morphogenesis","description":"This cluster is enriched for immune signaling terms (complement activation, lectin pathway; Fc-gamma receptor signaling; C-type lectin receptor signaling) and NK cell chemotaxis regulation, alongside development-related terms such as metanephric kidney morphogenesis, lymph vessel morphogenesis, and cartilage condensation. The common thread appears to be immune signaling activity associated with organ/tissue morphogenesis.","confidence":"Medium","size":21,"edges":207,"triangles":1274,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":19},{"id":"GO:0051873","count":19},{"id":"GO:0036303","count":19},{"id":"GO:0002223","count":19},{"id":"GO:0090403","count":19}]},{"hash":"746255322417789672","title":"Unknown","description":"The GO terms are highly diverse, spanning oxidative stress/detoxification, developmental and migratory processes (angiogenesis, coronary morphogenesis, axon guidance, B cell chemotaxis), neurotransmitter secretion, Notch signaling regulation, and proteolysis, with an outlier PHB biosynthesis term, indicating no single cohesive function for the cluster.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0098869","count":5},{"id":"GO:0002042","count":5},{"id":"GO:0048846","count":5},{"id":"GO:0007269","count":4}]},{"hash":"481933595952296917","title":"Cardiac morphogenesis and mesenchyme development","description":"Based on the top GO terms, this cluster centers on heart development and mesenchymal remodeling, including right ventricle and sinus venosus morphogenesis, floor plate development, BMP response, and Notch-related heart induction, with mesenchyme development and regulation of apoptosis as linked processes. The terms collectively point to cardiac morphogenesis and associated mesenchymal signaling.","confidence":"High","size":21,"edges":205,"triangles":1245,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071773","count":11},{"id":"GO:0003215","count":11},{"id":"GO:0045668","count":10},{"id":"GO:0060766","count":10},{"id":"GO:0010374","count":9}]},{"hash":"1966712579226259716","title":"Developmental signaling and transcriptional regulation","description":"It combines developmental signaling (Hippo, Wnt, ephrin receptor), development processes (multicellular organism and thyroid gland development), with core gene expression (translation, transcription) and cell cycle/ER-stress\u2013related signaling, suggesting a cluster of proteins coordinating developmental signaling with transcriptional regulation and growth control.","confidence":"High","size":21,"edges":12,"triangles":5,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0035329","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0007049","count":3}]},{"hash":"422603299083349975","title":"Larval chitin-based cuticle development","description":"Dominant annotation GO:0008363 indicates larval chitin-based cuticle development, shared by all 21 proteins, pointing to a cluster of factors involved in insect larval cuticle formation and chitin synthesis/assembly. This label is specific and representative of the cluster's likely function.","confidence":"High","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":21}]},{"hash":"493952282288264494","title":"Cardiovascular Signaling and Platelet Activation","description":"This cluster centers on heart development, cAMP signaling, Rho and ERK signaling, and platelet activation, pointing to a cohesive cardiovascular signaling theme including vascular tone and hemostasis. Peripheral terms related to neurons, drug response, and immune defense likely reflect shared signaling components rather than strict tissue-specific roles, yielding a medium confidence in the label.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":7},{"id":"GO:0007190","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0070374","count":5}]},{"hash":"852031337553679245","title":"Cardiovascular and hematopoietic development","description":"This cluster is enriched for heart development, blood vessel formation, hematopoiesis, VEGF response, and cell migration, suggesting a shared role in cardiovascular and immune/hematopoietic development. The presence of immune-related terms (IL-7 response, NK T cell differentiation) supports an immune-development theme, while sterol biosynthesis and sodium transport are less central but may reflect broader metabolic regulation in developing tissues.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":4},{"id":"GO:0010765","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0030097","count":2}]},{"hash":"1681472724787100574","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":201,"triangles":1167,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":11},{"id":"GO:0071374","count":1},{"id":"GO:1901621","count":1},{"id":"GO:0090084","count":1},{"id":"GO:0006458","count":1}]},{"hash":"1068625630673534146","title":"Neuronal ion transport and glutamate signaling","description":"This cluster centers on neural signaling and ion transport. Key terms include sodium, potassium, and calcium ion transport, the ionotropic glutamate receptor signaling pathway, and a lithium response, alongside serotonin metabolism and behavior-related terms (social behavior, forward locomotion) and anterior lateral line development. Together they point to proteins involved in ion-driven neurotransmission and sensory-neural development, rather than generic metabolic roles.","confidence":"High","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010226","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0042428","count":3},{"id":"GO:0035176","count":3}]},{"hash":"308500310056525360","title":"Embryogenesis and organ differentiation","description":"The set of top GO terms centers on developmental processes and tissue formation, including cartilage morphogenesis, left-right patterning, placenta and pancreatic development, and epithelial-to-mesenchymal transition in heart development. While there are some general cellular processes (mRNA splicing, Golgi-to-ER transport) also listed, the dominant theme is embryonic development and organ differentiation, justifying this label.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0035270","count":2}]},{"hash":"1880489152759592718","title":"Skeletal Muscle Fiber Development","description":"The dominant GO term is skeletal muscle fiber development (GO:0048741) with 18 proteins, indicating a coherent muscle development theme. While there are several unrelated terms (e.g., ubiquitination-related processes and immune regulation) present, the overwhelming majority point toward muscle formation. This suggests the cluster mainly comprises proteins involved in skeletal muscle development, with some annotations reflecting broader regulatory processes that accompany development. Confidence: High","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":18},{"id":"GO:0032764","count":17},{"id":"GO:0042787","count":17},{"id":"GO:2000312","count":17},{"id":"GO:1904431","count":17}]},{"hash":"1487830472473735285","title":"Musculoskeletal development and immune signaling regulators","description":"The terms cluster around musculoskeletal development (sarcomere organization, embryonic cranial skeleton morphogenesis, lung-associated mesenchyme development) and BMP/FGF signaling, pointing to developmental regulation. The presence of immune-related regulatory terms (granzyme B production, CD8+ T cell proliferation, TLR9 signaling modulation) suggests these proteins also modulate immune signaling. Together they imply a set of regulators balancing developmental processes with immune modulation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":2},{"id":"GO:0071663","count":2},{"id":"GO:0007275","count":2},{"id":"GO:2000566","count":2},{"id":"GO:0060484","count":2}]},{"hash":"1616511803050775294","title":"Neural development and synaptic signaling","description":"This group is heavily enriched for nervous system development terms (nervous system development, hippocampus development, dendrite morphogenesis) and synaptic activity (excitatory postsynaptic potential, calcium-dependent exocytosis). Dopamine response aligns with neuromodulatory signaling in neurons, supporting a neural-development/synaptic function theme. A few outliers (mitotic cell cycle, T cell receptor signaling) exist but do not override the dominant neural pattern.","confidence":"High","size":21,"edges":22,"triangles":3,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":20},{"id":"GO:0050852","count":20},{"id":"GO:0007399","count":20},{"id":"GO:0048813","count":20},{"id":"GO:0031647","count":20}]},{"hash":"978813635858212407","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0000294","count":1},{"id":"GO:0006364","count":1},{"id":"GO:1905267","count":1},{"id":"GO:0006379","count":1}]},{"hash":"295008931963899954","title":"Craniofacial and skeletal muscle development","description":"The top GO terms cluster around development of facial/craniofacial structures and the skeleton/muscle, including roof of mouth development, skeletal system development, and skeletal muscle fiber development. A few terms related to reproductive signaling appear, but the dominant signal points to craniofacial and musculoskeletal development, suggesting these proteins function in those processes.","confidence":"High","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0097211","count":2},{"id":"GO:2000354","count":2}]},{"hash":"524817710705953466","title":"Cartilage and collagen matrix formation","description":"The cluster is dominated by GO terms related to collagen fibril organization, collagen biosynthesis, and cartilage development (including endochondral bone morphogenesis and growth plate chondrocyte development), plus cell adhesion. This points to a cohesive theme of extracellular matrix assembly and cartilage tissue morphogenesis, with a few terms like oviduct morphogenesis likely representing broader morphogenesis roles or annotation noise.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":2},{"id":"GO:0051873","count":2},{"id":"GO:0060351","count":2},{"id":"GO:0035987","count":2},{"id":"GO:0003431","count":2}]},{"hash":"1671304144845143505","title":"CNS Myelination and Immune Signaling","description":"Top terms indicate neural development processes (synapse organization, CNS myelination, positive regulation of myelination) alongside immune-related activities (antigen processing via MHC I, chemokine production, granzyme B production) and cell signaling/cytoskeleton regulation (Rho signaling, Kv channel clustering, sarcomere organization). The collection suggests a cluster of proteins involved in nervous system maturation with concurrent immune signaling and cytoskeletal remodeling, rather than a single straightforward pathway, hence the label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905065","count":3},{"id":"GO:0090197","count":3},{"id":"GO:0050808","count":3},{"id":"GO:0042590","count":3},{"id":"GO:0035023","count":3}]},{"hash":"1834595161507406176","title":"Visual and auditory perception with dopaminergic signaling","description":"This cluster is dominated by GO terms related to sensory perception and neural signaling, notably visual perception and visual learning, inner ear development, and dopaminergic synaptic transmission, along with signaling pathways (ERK cascade) and related ion transport. While one term is developmental and another obsolete, the strongest themes point to sensory processing\u2014especially vision and hearing\u2014and associated neural signaling, justifying a label around visual/auditory perception and dopaminergic signaling.","confidence":"High","size":21,"edges":27,"triangles":23,"max_degree":8,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0019233","count":12},{"id":"GO:0007275","count":11},{"id":"GO:0048839","count":9},{"id":"GO:0006349","count":9},{"id":"GO:0071380","count":9}]},{"hash":"1112168040055582539","title":"mRNA maturation and export","description":"The terms are dominated by post-transcriptional RNA processing steps: mRNA polyadenylation, export from the nucleus, various RNA modification and splicing activities, and formation of the translation preinitiation complex, with some links to regulatory ncRNA-mediated gene silencing. This pattern strongly suggests a cluster of proteins involved in RNA maturation and early translation regulation.","confidence":"High","size":21,"edges":4,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":4},{"id":"GO:0006406","count":4},{"id":"GO:0075525","count":3},{"id":"GO:1901407","count":3},{"id":"GO:1902625","count":3}]},{"hash":"326305770670541404","title":"Embryonic Development and Organ Morphogenesis","description":"This cluster centers on developmental processes and morphogenesis, with GO terms covering endocrine development, heart-related EMT in the endocardial cushion, cartilage morphogenesis, left-right patterning, placental and pancreatic development, and tissue differentiation. While a few terms (e.g., receptor internalization) are more cellular or metabolic, the dominant signal points to embryonic organogenesis and lineage specification, justifying a developmental/morphogenesis label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060972","count":4}]},{"hash":"1112929092601274176","title":"Neural development and axon guidance signaling","description":"The cluster is enriched for nervous system development terms (brain/hippocampus) along with multiple axon guidance and developmental signaling pathways, including Roundabout (ROBO), ephrin receptor signaling, Hedgehog (Smoothened) and Wnt signaling, and regulation of axonogenesis. This combination points to a coherent theme of neural development and axon pathfinding, with some immune signaling term present as a minor association. ","confidence":"High","size":21,"edges":155,"triangles":557,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001822","count":9},{"id":"GO:0007399","count":8},{"id":"GO:0007224","count":8},{"id":"GO:0050771","count":7},{"id":"GO:0050852","count":7}]},{"hash":"325440172165990316","title":"Organogenesis Across Tissues","description":"The proteins are enriched for GO terms spanning multiple organ development processes (heart muscle proliferation; bone mineralization; chondrocyte differentiation; lung alveolus development; face morphogenesis; pituitary gland and digestive tract development), indicating a broad, multi-tissue organogenesis theme rather than a single specific function.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060038","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0046827","count":2},{"id":"GO:0030501","count":2},{"id":"GO:0032332","count":2}]},{"hash":"806915541264942038","title":"Ubiquitin-regulated immune signaling","description":"The cluster\u2019s top terms center on ubiquitination processes (ubiquitin-dependent protein catabolic process; K33-linked ubiquitination; negative regulation of protein ubiquitination) and immune-related regulation (mast cell cytokine production, IgE isotype switching, dendritic cell differentiation). Despite some noisy or obsolete terms, the common thread suggests proteins involved in ubiquitin-mediated modifications that modulate immune signaling and immune cell differentiation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032764","count":5},{"id":"GO:0042787","count":5},{"id":"GO:2000312","count":5},{"id":"GO:1904431","count":5},{"id":"GO:0045497","count":5}]},{"hash":"2290600864855035941","title":"Cell cycle signaling and trafficking","description":"This cluster centers on cell division and cell cycle processes, with supporting roles for translation, Wnt and ephrin signaling, and a strong emphasis on membrane trafficking and cytoskeletal regulation (endocytic recycling, vacuole targeting, filopodium dynamics), suggesting coordinated cell growth, signaling, and trafficking.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0006412","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0048013","count":2}]},{"hash":"2052082861053513928","title":"Innate Immunity and Coagulation","description":"The top GO terms are strongly centered on defense responses (defense against fungus), innate immune processes (complement activation, lectin pathway), and coagulation, with elastin catabolic remodeling suggesting tissue inflammation. Other terms like transcription regulation and development are less directly connected but do not outweigh the core immune/coagulation theme. This makes the label a concise, representative description of the cluster\u2019s main functional pattern.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0050832","count":5},{"id":"GO:0007596","count":5},{"id":"GO:1900738","count":5},{"id":"GO:0009791","count":5}]},{"hash":"2282285559087169896","title":"Signaling Regulation and Stress Response","description":"The terms point to broad regulation of cellular signaling (e.g., negative regulation of MAP kinase activity, regulation of protein dephosphorylation), protein turnover (proteasomal degradation), and responses to various stimuli and stress (pH, oxidative stress, inflammatory signaling, thyroid hormone), with a touch of development signals (neuron projection development). This suggests a theme of coordinating signaling and stress-responsive processes rather than a single, cohesive metabolic pathway, hence a label focused on signaling regulation and stress response.","confidence":"Medium","size":21,"edges":29,"triangles":10,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035307","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0036473","count":2},{"id":"GO:0009268","count":2},{"id":"GO:0043407","count":2}]},{"hash":"532495331767645175","title":"Hematopoiesis and T cell signaling regulation","description":"The GO terms cluster around blood/immune development and signaling\u2014megakaryocyte development, KIT signaling, and regulation of T cell receptor signaling and IL-2 production\u2014pointing to hematopoietic lineage specification and T-cell modulation. Heart development appears but is less central; overall, the proteins seem to participate in hematopoietic/immune system processes with modest interconnectivity.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035855","count":6},{"id":"GO:0050860","count":6},{"id":"GO:0007507","count":5},{"id":"GO:0051092","count":5},{"id":"GO:0046007","count":5}]},{"hash":"2005189185654053792","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000453","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0009234","count":3},{"id":"GO:0009102","count":3},{"id":"GO:0009636","count":3}]},{"hash":"1024652674776201458","title":"Unknown","description":"The top GO terms span diverse areas: amino acid and lipid metabolism, central carbon metabolism (oxaloacetate), kynurenine catabolism, and plant-specific processes like fruit ripening and systemic acquired resistance, plus an animal signaling pathway (Notch). The mix, including obsolete terms, does not point to a single cohesive function or theme for the cluster, so no clear label can be assigned.","confidence":"","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019878","count":9},{"id":"GO:0042853","count":8},{"id":"GO:0007219","count":8},{"id":"GO:0033512","count":8},{"id":"GO:0006107","count":8}]},{"hash":"732620175093024865","title":"Steroid and lipid biosynthesis","description":"Most of the top GO terms describe biosynthesis of steroids and lipids (glucocorticoid biosynthetic, C21-steroid hormone metabolic, sphingolipid and mycolic acid biosynthesis, and related lipid pathways), plus other biosynthetic routes like tetrahydrobiopterin and alkaloids. A few terms (lung development, acetoin catabolism) are peripheral, but the dominant theme is enzymatic synthesis of complex lipids and steroid metabolites, justifying the Steroid and lipid biosynthesis label.","confidence":"High","size":21,"edges":71,"triangles":64,"max_degree":13,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":18},{"id":"GO:0030324","count":15},{"id":"GO:0042619","count":14},{"id":"GO:0006704","count":14},{"id":"GO:0008207","count":14}]},{"hash":"940833201618031210","title":"Auditory hair cell mechanosensation","description":"The two most frequent GO terms point to auditory receptor cell stereocilium organization and detection of mechanical stimulus in hearing, suggesting the cluster's function relates to hair cell mechanotransduction in the ear. Other terms appear unrelated or obsolete, indicating noise in the data, but the core signal supports an auditory mechanosensory theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060088","count":2},{"id":"GO:0050910","count":2},{"id":"GO:0043709","count":1},{"id":"GO:1900471","count":1},{"id":"GO:2000210","count":1}]},{"hash":"1672928875462903918","title":"Unknown","description":"The GO terms are scattered across distinct processes\u2014pollen tube guidance (plant development) and general glycosylation-related biosynthesis (dolichol-linked oligosaccharide biosynthesis, GPI anchor biosynthesis) plus peptidyl-glutamic acid carboxylation\u2014with no evident unifying function. Additionally, there are no edges or interactions among the proteins (max degree 0, no triangles), indicating a lack of a cohesive functional cluster to name. ","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010183","count":1},{"id":"GO:0006488","count":1},{"id":"GO:0006506","count":1},{"id":"GO:0017187","count":1}]},{"hash":"1223343087665277660","title":"Developmental Morphogenesis and Hormonal Signaling","description":"The proteins are linked to developmental morphogenesis (cuticle development, pituitary morphogenesis) and meiotic development (synaptonemal complex assembly, male meiosis I), while also showing signals from hormonal pathways (thyroid hormone metabolism, cAMP response, GPCR signaling) and ROS-related processes, suggesting a theme of development regulated by hormonal and signaling mechanisms, though the terms span diverse functions.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008365","count":2},{"id":"GO:0042403","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0048855","count":2},{"id":"GO:0050665","count":2}]},{"hash":"1143333872655785182","title":"Developmental signaling and apoptosis","description":"The top GO terms span development-related processes (sarcomere organization, nervous system development, epithelial migration, posterior head segmentation) and signaling pathways (Rho signaling, Smoothened/hedgehog signaling), with accompanying apoptotic processes (mitochondrial membrane permeability in apoptosis, apoptosis). This suggests a broad cluster of proteins involved in developmental signaling and cell fate decisions rather than a single, tightly defined pathway.","confidence":"Low","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0007224","count":2}]},{"hash":"787448378760687717","title":"Thermogenesis and smooth muscle signaling","description":"This cluster centers on thermogenic responses (temperature stimulus and diet-induced thermogenesis) and signaling that regulates smooth muscle and vascular function, including calcium signaling, muscle relaxation/contraction, vascular permeability, prostaglandin and hormone signaling, and ERK pathway activity. Pain-related signaling here may reflect nociceptive or inflammatory links to these pathways, but the core theme ties thermogenesis to smooth muscle/vascular regulation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0051209","count":4},{"id":"GO:0090075","count":3}]},{"hash":"1515690367044344594","title":"Cardiovascular development and immune signaling","description":"The top GO terms cluster around heart development and angiogenesis, with ERK1/2 cascade regulation and positive regulation of protein secretion, suggesting a core function in vascular/cardiac development and their signaling networks. Immune-related terms (adaptive immune response) appear alongside, indicating coordinated signaling between cardiovascular development and immune pathways. Some terms are peripheral (e.g., dendritic spine regulation, symbiont entry), but the predominant pattern supports a cardiovascular development with immune signaling theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0002250","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0050714","count":4},{"id":"GO:0045907","count":4}]},{"hash":"2222055960934092499","title":"Lipid and steroid biosynthesis","description":"The top GO terms cluster around biosynthesis of lipids and steroid-related compounds, including poly-hydroxybutyrate, sphingolipids, mycolic acids, and glucocorticoids/steroid hormones. A few terms like antibiotic biosynthesis are related to secondary metabolite production that can involve lipid-like pathways, but the dominant theme across the terms is lipid- and steroid-type biosynthesis. ","confidence":"High","size":20,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0017000","count":4},{"id":"GO:0009234","count":3},{"id":"GO:1902987","count":3}]},{"hash":"431873667630265820","title":"Developmental Signaling and Differentiation","description":"Enriched terms cluster around canonical Wnt signaling and Hippo signaling, with strong links to nervous system development, keratinocyte differentiation, and ephrin receptor signaling, plus apoptosis and adhesion-related processes. This points to proteins participating in developmental signaling networks that coordinate cell fate decisions, tissue development, and morphogenesis across multiple lineages rather than a single pathway. Therefore, a cohesive label capturing developmental signaling and differentiation makes sense.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":12},{"id":"GO:0060044","count":10},{"id":"GO:0035329","count":10},{"id":"GO:0006915","count":10},{"id":"GO:0030216","count":10}]},{"hash":"2027144862421993693","title":"Microtubule dynamics and cell junction regulation","description":"The top GO terms cluster around microtubule activity (plus- and minus-end sliding, axonemal depolymerization, general microtubule-based processes) and adherens junction maintenance, with supporting roles in epithelial stem cell homeostasis and neuronal layer organization, suggesting a cohesive role in cytoskeletal remodeling linked to cell\u2013cell adhesion.","confidence":"High","size":20,"edges":74,"triangles":115,"max_degree":18,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000742","count":15},{"id":"GO:0001560","count":13},{"id":"GO:0031535","count":13},{"id":"GO:0045218","count":13},{"id":"GO:0036334","count":13}]},{"hash":"1299878350015985189","title":"Cardiac muscle signaling and contraction","description":"The cluster shows several GO terms tied to heart function: regulation of SA node, atrial and AV node action potentials, Purkinje signaling, and positive regulation of the force of heart contraction, along with calcium release from the sarcoplasmic reticulum, all indicating cardiac excitation-contraction coupling and electrical conduction. Some terms are broad (multicellular development, mitotic cell cycle) and one outlier term references insect cuticle development, which may be a cross-species annotation artifact. Overall, the dominant theme aligns with cardiac muscle signaling and contraction.","confidence":"Medium","size":20,"edges":71,"triangles":184,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008363","count":13},{"id":"GO:0014808","count":3},{"id":"GO:0098907","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0098910","count":3}]},{"hash":"363760213902729584","title":"Pain and Inflammatory GPCR-cAMP Signaling","description":"This cluster centers on GPCR signaling that activates adenylate cyclase and downstream cAMP pathways, together with pain-related and inflammatory responses (including morphine response, lipopolysaccharide/xenobiotic responses, and sensory perception of pain). Additionally, there are terms related to vascular regulation (blood pressure and smooth muscle contraction), suggesting a role in neuroimmune signaling that can influence vascular tone. The electron transport chain term is less central but could reflect cellular energy needs in signaling cells. Overall, the dominant theme is GPCR-cAMP\u2013mediated pain and inflammatory signaling.","confidence":"Medium","size":20,"edges":7,"triangles":1,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":8},{"id":"GO:0007190","count":8},{"id":"GO:0010579","count":8},{"id":"GO:0022900","count":8},{"id":"GO:0045986","count":7}]},{"hash":"511553169101463838","title":"RTK/MAPK/Wnt Signaling Regulators","description":"GO terms point to multiple signaling activities, including ephrin receptor signaling (RTK-like), ERK/MAPK cascade, and canonical Wnt signaling, along with regulation of T cell receptor signaling, focal adhesion assembly, and axonogenesis. This suggests a set of proteins that broadly modulate signaling networks and phosphorylation events rather than a single pathway. The label RTK/MAPK/Wnt Signaling Regulators captures these interconnected pathways.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048013","count":14},{"id":"GO:0043552","count":14},{"id":"GO:0090263","count":14},{"id":"GO:0051893","count":14},{"id":"GO:0050771","count":14}]},{"hash":"938207783316958296","title":"Chromatin Regulation and Transcriptional Control","description":"Most terms point to chromatin state and nuclear transcription regulation (negative regulation of RNA Pol II transcription, histone methylation, heterochromatin formation, chromosome condensation, and chromatin localization), with additional notes on development-related processes (osteoblast and spermatid development). This suggests a coherent theme of chromatin organization governing gene expression and differentiation. ","confidence":"High","size":20,"edges":153,"triangles":633,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0061086","count":4},{"id":"GO:0000183","count":4},{"id":"GO:0071674","count":4},{"id":"GO:0001649","count":4}]},{"hash":"1316693560602213604","title":"Actin Cytoskeleton Remodeling and Endocytosis","description":"The cluster\u2019s top GO terms cluster around actin-related processes (stress fiber and filopodium assembly), regulation of GTPase activity, and membrane trafficking (regulation of synaptic vesicle endocytosis), suggesting a common theme of dynamic cytoskeletal remodeling coupled to vesicle movement. Some terms like abscisic acid signaling and bone ossification appear noisy or broadly related to signaling, but the core signals point to cytoskeleton dynamics and endocytosis driving the cluster\u2019s function.","confidence":"Medium","size":20,"edges":16,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0009738","count":3},{"id":"GO:0051262","count":3},{"id":"GO:0051489","count":2},{"id":"GO:0016237","count":2}]},{"hash":"288637161556329963","title":"Neural signaling and sensory perception","description":"The cluster is enriched for neural/sensory GO terms: visual perception, visual learning, sensory perception of pain, and dopaminergic synaptic transmission, plus ERK1/ERK2 cascade regulation and cocaine-related behavior. While there are some non-neuronal terms (heart development, mitotic cell cycle), the dominant signals point to neural signaling and sensory processing.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0048148","count":3}]},{"hash":"1375541216092498326","title":"Glutamatergic signaling and ion transport","description":"The cluster is driven by neural-related GO terms, especially ionotropic glutamate receptor signaling, plus transport of Na+, K+, and Ca2+. This points to a cohesive neuronal signaling module underlying excitation and neurotransmission, with locomotion and lateral line development hints supporting a neural function theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010226","count":4},{"id":"GO:0035176","count":3},{"id":"GO:0010157","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0043056","count":3}]},{"hash":"1627906786032475217","title":"Steroid hormone and prostaglandin biosynthesis with xenobiotic metabolism","description":"This cluster is dominated by terms for biosynthesis and metabolism of steroid hormones (androgen, testosterone, cortisol) and lipid mediators (prostaglandins/oxylipins), along with multiple xenobiotic processing terms (omega-hydroxylase P450 pathway, xenobiotic and dioxin/benzo-dioxin catabolic processes). The convergence of hormone and lipid mediator production with detoxification pathways suggests a cohesive functional theme around steroid/lipid hormone synthesis and xenobiotic metabolism.","confidence":"High","size":20,"edges":12,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":11},{"id":"GO:0033076","count":10},{"id":"GO:0008209","count":10},{"id":"GO:0061370","count":10},{"id":"GO:0042738","count":9}]},{"hash":"2050152594415604890","title":"DNA transposition and proviral integration","description":"The terms cluster around transposable element activity and proviral processes (DNA transposition, retrotransposition, DNA integration, proviral latency, and viral entry into the host nucleus), indicating a cohesive focus on mobile genetic elements and provirus-related integration; a few general cellular terms are present but do not override this theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0032197","count":3},{"id":"GO:0039651","count":3}]},{"hash":"1029088257429128508","title":"Ubiquitin-Dependent Protein Turnover and NF-kB Signaling","description":"The top GO terms are dominated by ubiquitin-dependent protein catabolic processes and autoubiquitination, with related influences on apoptosis and NF-kappaB-inducing kinase activation. There are also histone turnover-related terms, suggesting a broader theme of ubiquitin-mediated regulation of protein stability and chromatin-associated signaling. Altogether, the cluster appears to group proteins involved in ubiquitin-tagged degradation and modulation of inflammatory signaling and cell survival.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0051865","count":8},{"id":"GO:1903265","count":8},{"id":"GO:0085020","count":8},{"id":"GO:0036205","count":8}]},{"hash":"683504889833355237","title":"Unknown","description":"These proteins show a mix of diverse processes\u2014larval cuticle and corneocyte development, placental differentiation, xenobiotic response, cAMP signaling, and DNA repair/recombination\u2014without a single coherent function tying them together, so a meaningful cluster label cannot be confidently assigned.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0060707","count":2},{"id":"GO:0042493","count":1},{"id":"GO:0003335","count":1},{"id":"GO:0071320","count":1}]},{"hash":"1311170604909640403","title":"Neural development transcriptional regulators","description":"This cluster is enriched for neural development terms, including forebrain development and neural tube closure, along with multicellular organism development and DNA-templated transcription. This pattern points to transcriptional regulators driving neural development. Some stress/immune terms (ER stress, cadmium response, defense to Gram-positive bacteria) may reflect pleiotropic roles or broader cellular stress responses rather than core neural-development functions.","confidence":"High","size":20,"edges":15,"triangles":3,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":13},{"id":"GO:0001403","count":11},{"id":"GO:0007275","count":11},{"id":"GO:0001843","count":11},{"id":"GO:0000278","count":11}]},{"hash":"537508764758326733","title":"Mitochondrial Translation and Electron Transport","description":"Most terms are about mitochondrial translation (including mitochondrial translation) and mitochondrial NADH-to-ubiquinone electron transport, with additional signals for protein modification. This points to a cluster of mitochondrial protein synthesis machinery and energy production components.","confidence":"High","size":20,"edges":30,"triangles":3,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0032543","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0016310","count":2}]},{"hash":"1425233866196636314","title":"Glutamatergic Synaptic Transmission and Plasticity","description":"The terms converge on excitatory glutamatergic signaling, calcium-dependent synaptic activity, and plasticity (LTP/LTD), which underlie memory and behavior, including sensory processing and social behaviors.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007616","count":9},{"id":"GO:0006816","count":9},{"id":"GO:0001975","count":9},{"id":"GO:0060079","count":9},{"id":"GO:1900273","count":9}]},{"hash":"1805073081882617359","title":"ER Stress Response and Protein Folding","description":"The cluster is dominated by GO terms for endoplasmic reticulum stress response and ER protein folding, plus ER lumen retention and redox/homeostasis processes, indicating a cohesive group focused on ER quality control and unfolded protein response, with some transcriptional regulation components reflecting stress-induced gene expression changes.","confidence":"High","size":20,"edges":53,"triangles":76,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034976","count":9},{"id":"GO:0045454","count":9},{"id":"GO:1903206","count":9},{"id":"GO:0034975","count":9},{"id":"GO:0098869","count":8}]},{"hash":"927972394913805982","title":"Cell Cycle and Protein Turnover","description":"The cluster is rich in core cell cycle terms (mitotic cell cycle, DNA replication, cell division, cell population proliferation) indicating a primary theme around cell proliferation. It also includes proteasomal ubiquitin-dependent protein catabolic process and translation initiation/reinitiation, suggesting coordinated protein turnover and synthesis during growth. Intralumenal vesicle formation and positive regulation of GTPase activity imply trafficking and signaling processes that support cell division and morphogenesis. Together, these terms reflect a cohesive cluster of proteins involved in cell cycle progression with associated protein homeostasis and trafficking functions.","confidence":"Medium","size":20,"edges":92,"triangles":204,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":6},{"id":"GO:0032436","count":5},{"id":"GO:0070676","count":5},{"id":"GO:0000902","count":5},{"id":"GO:0051301","count":5}]},{"hash":"169995915095618494","title":"Golgi-ER Vesicle Trafficking","description":"The cluster shows strong enrichment for GO terms related to ER-to-Golgi transport, intra-Golgi transport, vesicle fusion with the Golgi, and Golgi ribbon formation, indicating a shared role in Golgi-based vesicular trafficking and the secretory pathway, with some additional, less central terms such as development and signaling.","confidence":"High","size":20,"edges":5,"triangles":1,"max_degree":4,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0006888","count":6},{"id":"GO:0071560","count":4},{"id":"GO:0006891","count":4},{"id":"GO:0090161","count":4},{"id":"GO:0060291","count":4}]},{"hash":"1169667856866750566","title":"Wnt-driven development and morphogenesis","description":"Top terms collected from the cluster point to developmental signaling and tissue formation, notably the Wnt signaling pathway, pancreas morphogenesis, and angiogenesis/organ growth. While there are some peripheral terms (defense responses, glucose stimulus, transcription regulation) that may reflect broader protein roles or annotation noise, the core pattern supports a theme of developmental signaling and morphogenesis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:0035264","count":5},{"id":"GO:0061113","count":5},{"id":"GO:0016055","count":5},{"id":"GO:0045766","count":5}]},{"hash":"1607278853980496857","title":"Multisubstrate Transmembrane Transport","description":"The top GO terms point to transmembrane transport across membranes for diverse substrates (nitrite, sialic acid, fucose, galactose, arabinose, phosphate ions, vitamins, 4-hydroxyphenylacetate, xenobiotics), indicating these proteins are membrane transporters with broad substrate specificity rather than a single substrate pathway.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0015739","count":2},{"id":"GO:0006004","count":2}]},{"hash":"94207701117165504","title":"Chitin catabolism and inflammatory signaling","description":"This cluster is enriched for the chitin catabolic process and inflammatory mediator production, including positive regulation of chemokine production, along with broad carbohydrate metabolism. The combination suggests proteins involved in degrading chitin and triggering inflammatory signaling, pointing to an immune/inflammatory role linked to chitin metabolism.","confidence":"High","size":20,"edges":6,"triangles":1,"max_degree":5,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0005975","count":15},{"id":"GO:0002532","count":15},{"id":"GO:0006032","count":15},{"id":"GO:0090197","count":15}]},{"hash":"872819869617049951","title":"Neural development and synaptic signaling","description":"The top GO terms cluster around neural development and synaptic function, including retinal axon guidance, multicellular development, and morphogenesis, along with transcriptional regulation and synaptic transmission (glutamatergic) and potentiation. This pattern suggests the proteins are involved in nervous system development and subsequent synaptic communication, with transcriptional control underpinning neuronal gene expression. Some terms also reflect general development pathways, but the convergence on neural guidance and synaptic activity dominates the theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060670","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0060017","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0031290","count":2}]},{"hash":"1561190236965662133","title":"Innate Immunity and Cuticle Remodeling","description":"Top terms show innate immune activity via complement activation (lectin and classical pathways) and inflammatory mediator production, paired with developmental remodeling of the cuticle (chitin catabolic processes and larval cuticle development) and extracellular matrix turnover (collagen catabolic). Additional carbohydrate metabolism and sugar transport terms may support these processes. The cluster thus appears to combine immune response with structural remodeling of the cuticle in an invertebrate context.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0030574","count":2},{"id":"GO:0008363","count":1},{"id":"GO:0005975","count":1}]},{"hash":"859120791781897263","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070317","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0051568","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0006351","count":3}]},{"hash":"1784139238071861765","title":"ECM Proteoglycan Biosynthesis","description":"This cluster is driven by GO terms for dermatan sulfate and chondroitin sulfate proteoglycan biosynthesis, pointing to extracellular matrix (ECM) proteoglycan production as the core theme. The accompanying terms on brain development and apoptotic remodeling suggest contexts where ECM biosynthesis is dynamically involved in development and tissue remodeling, and even sperm\u2013zona pellucida interactions can relate to ECM components. Taken together, the dominant signal is proteoglycan/ECM biosynthesis with related developmental processes.","confidence":"Medium","size":20,"edges":12,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":8},{"id":"GO:0006049","count":6},{"id":"GO:0035010","count":6},{"id":"GO:0035284","count":6},{"id":"GO:0075015","count":4}]},{"hash":"794589686687575768","title":"Unknown","description":"The terms hint at neural processes (neurotransmitter biosynthesis, anesthesia-resistant memory, circadian rhythm) but also include unrelated processes (fibroblast migration, luteinization, xenobiotic/pyrethroid responses). There isn\u2019t a single coherent function tying all terms together, so Unknown with None confidence. ","confidence":"","size":20,"edges":110,"triangles":285,"max_degree":17,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0042136","count":6},{"id":"GO:0006538","count":6},{"id":"GO:0007615","count":6},{"id":"GO:0046684","count":6},{"id":"GO:0009449","count":6}]},{"hash":"221236606554182757","title":"Unknown","description":"The GO terms are diverse (ribosome biogenesis, chromatin organization, ubiquitin-dependent protein degradation, various regulatory/metabolic processes, and organellar transcription) with no dominant shared function or interaction among the proteins, so there is no cohesive theme to label beyond Unknown.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0031497","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0090180","count":2},{"id":"GO:1903212","count":2}]},{"hash":"1951071558617620294","title":"Ubiquitin-Dependent Proteolysis and Histone Regulation","description":"The proteins are enriched for ubiquitination-related GO terms (ubiquitin-dependent protein catabolic process, autoubiquitination, K48- and K6-linked ubiquitination) and histone catabolic processes, pointing to a shared function in ubiquitin-mediated protein turnover and chromatin regulation. Some immune signaling terms are present, but the dominant theme is ubiquitin-driven proteolysis and histone regulation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0051865","count":6},{"id":"GO:2001200","count":5},{"id":"GO:0050853","count":5},{"id":"GO:0070936","count":5}]},{"hash":"2216507024219091122","title":"Actin Cytoskeleton Remodeling and Protrusion Formation","description":"The enrichment of lamellipodium and filopodium assembly terms, along with Rho signaling, points to actin-driven cytoskeletal remodeling that produces membrane protrusions and drives cell motility. Additional terms like platelet aggregation and odontogenesis reflect cytoskeletal roles in diverse contexts, but the core theme remains actin dynamics governing protrusive structures. With no network topology signals (edges/triangles), the cluster seems defined by shared functional GO annotations rather than interactions, yet the terms cohesively describe actin-based remodeling.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":3},{"id":"GO:0046847","count":3},{"id":"GO:0007266","count":3},{"id":"GO:0045880","count":3},{"id":"GO:0051291","count":3}]},{"hash":"656214076549716213","title":"Transmembrane metabolite and ion transporters","description":"This cluster is dominated by GO terms for transmembrane transport, including UDP-glucose transport, phosphoenolpyruvate import into the Golgi, triose phosphate and phosphoglycerate transport, amino acid export, and calcium ion export. The common thread is membrane transport of sugars, metabolites, and ions across different membranes, though substrates vary.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0048527","count":1},{"id":"GO:1990034","count":1},{"id":"GO:0015713","count":1},{"id":"GO:0015786","count":1}]},{"hash":"1739879227318513489","title":"Developmental morphogenesis across organs","description":"This cluster centers on organ development and tissue morphogenesis across diverse tissues (retina/eye, lung, heart outflow tract, bone, muscle, prostate) plus transcriptional control processes, suggesting a shared developmental program.","confidence":"High","size":20,"edges":95,"triangles":144,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002087","count":8},{"id":"GO:0002076","count":8},{"id":"GO:0060041","count":8},{"id":"GO:0006366","count":7},{"id":"GO:0048048","count":7}]},{"hash":"2272577328411671088","title":"Multisystem Development and Differentiation","description":"This cluster is enriched for GO terms centered on development and differentiation across multiple tissues and cell types (megakaryocyte development, multicellular organism development, neuron projection development, skeletal system development, lens fiber cell differentiation, platelet formation, and single fertilization). A few signaling-related terms (negative regulation of protein tyrosine kinase activity, regulation of Rho signaling) align with general differentiation processes. The presence of an immune defense term is ancillary. Overall, the set points to broad developmental programs rather than a single pathway, justifying the multisystem development label.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035855","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0031175","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0050830","count":4}]},{"hash":"108939109822512323","title":"Morphogenesis and Rho/Rac GTPase signaling","description":"The terms cluster around developmental morphogenesis (midbrain, pericardium, cardiac atrium) and Rho/Rac-mediated signal transduction and GTPase activation, indicating a theme of morphogenesis regulated by small GTPases.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043303","count":2},{"id":"GO:0007296","count":2},{"id":"GO:1904693","count":2},{"id":"GO:2000973","count":2},{"id":"GO:0035022","count":2}]},{"hash":"920279159883373103","title":"Developmental Differentiation Across Tissues","description":"This cluster centers on broad developmental and differentiation processes across multiple tissues, including neural development (neuron projection development, neuron migration, ventricular zone neuroblast division), skeletal/eye tissues (skeletal system development, lens fiber cell differentiation), and even immune-related differentiation (dendritic cell differentiation, granzyme B production) as well as structural maturation (sarcomere organization, potassium channel clustering). The common thread is tissue- and cell-type\u2013specific development rather than a single pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0001501","count":3},{"id":"GO:2001200","count":3},{"id":"GO:0070306","count":3}]},{"hash":"295844611236549863","title":"Proteoglycan and glycosaminoglycan biosynthesis","description":"The top GO terms point to biosynthesis of proteoglycans and glycosaminoglycans, including heparan sulfate, keratan sulfate, and heparin proteoglycans, as well as sulfation-related processes (peptidyl-tyrosine sulfation and sulfate assimilation). This suggests the cluster is enriched for extracellular matrix component biosynthesis and modification. Some other terms (DNA replication, fat cell differentiation, angiotensin regulation) are less central, but overall the GAG/proteoglycan biosynthesis theme is dominant.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0006478","count":2},{"id":"GO:0015012","count":2},{"id":"GO:0002002","count":2}]},{"hash":"807117400141721529","title":"Neural\u2013cardiovascular signaling","description":"This cluster centers on GO terms related to ERK cascade regulation, nerve impulse transmission, heart development, vasoconstriction, and platelet activation, suggesting a shared theme of signaling that coordinates neural and cardiovascular functions. Additional terms touch on locomotory behavior, immune defense, UV-B response, and drug responses, indicating broader stress and behavioral signaling. The absence of observed edges among proteins suggests these proteins may participate in diverse pathways or be co-annotated rather than forming a single molecular complex, so Neural\u2013cardiovascular signaling is a reasonable, moderate-confidence label.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0007626","count":2},{"id":"GO:0030168","count":2},{"id":"GO:0001975","count":2},{"id":"GO:0033861","count":2}]},{"hash":"1015872967220747358","title":"Rho/Rac GTPase-regulated cytoskeleton and cell junctions","description":"This cluster is enriched for GO terms related to actin cytoskeleton organization, negative regulation and modulation of Rho/Rac GTPase signaling, and tight junction assembly, as well as skin barrier establishment and Golgi localization. These collectively point to a core theme of cytoskeletal dynamics and cell\u2013cell junction regulation governed by small GTPases, with ancillary links to membrane trafficking. Therefore, the label captures the most representative function of the group.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045671","count":3},{"id":"GO:0070830","count":2},{"id":"GO:0051683","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0035021","count":2}]},{"hash":"738171647060683232","title":"Lectin- and Fc receptor-mediated immune signaling","description":"This cluster most strongly reflects immune activation pathways, with enrichment for stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, and complement activation via the lectin pathway. While there are outliers related to proteolysis/ERAD and some developmental terms, the shared theme across the top terms is innate immune signaling through lectin and Fc receptor\u2013linked pathways, suggesting a coherent immune-function cluster. Confidence: Medium","confidence":"Medium","size":19,"edges":13,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0072218","count":3},{"id":"GO:0051873","count":3},{"id":"GO:0036303","count":3}]},{"hash":"1792443494007634567","title":"Diverse Transmembrane Transport","description":"The top GO terms are dominated by various transmembrane transport activities (across substrates such as 4-hydroxyphenylacetate, nitrite, xenobiotics, sialic acid, vitamins, galactose, arabinose, and phosphate ions), with fucose metabolic process also present. This suggests the cluster comprises membrane transport proteins with diverse substrate specificities, rather than a single substrate-focused function. Therefore, a general label reflecting multiple substrate transport across membranes is most appropriate.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":1},{"id":"GO:0015707","count":1},{"id":"GO:0006855","count":1},{"id":"GO:0015739","count":1},{"id":"GO:0006004","count":1}]},{"hash":"132472558777498601","title":"Organ morphogenesis with immune signaling","description":"The Top Terms include kidney development (metanephric ascending thin limb and distal tubule morphogenesis), lymphatic and cartilage morphogenesis, and multiple immune signaling pathways (C-type lectin receptor, Fc-gamma receptor signaling, lectin pathway complement activation) plus NK cell chemotaxis regulation. This combination suggests proteins involved in developmental tissue remodeling that also engage innate immune signaling, hence the label.","confidence":"Medium","size":19,"edges":31,"triangles":16,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":16},{"id":"GO:0051873","count":16},{"id":"GO:0036303","count":16},{"id":"GO:0002223","count":16},{"id":"GO:0090403","count":16}]},{"hash":"2234192192145207750","title":"Mitochondrial Translation and Respiratory Chain","description":"The strongest signal in this cluster is translation (GO:0006412), seen with multiple proteins, complemented by mitochondrial respiration signals (electron transport chain; complex I assembly), suggesting a mitochondrial module tied to protein synthesis and assembly of the respiratory machinery. Additional terms like brain development and transcription-related processes appear less central and may reflect broader or pleiotropic annotations. Overall, the cluster seems to center on mitochondrial function, particularly translation-linked energy production, rather than a single nuclear pathway. ","confidence":"Medium","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":9},{"id":"GO:0046677","count":2},{"id":"GO:0022900","count":1},{"id":"GO:0032981","count":1},{"id":"GO:0019933","count":1}]},{"hash":"1994785999688867209","title":"Amino acid transport and osmoregulation","description":"Most terms describe transmembrane transport of amino acids and related osmolytes (arginine, lysine, polyamines, carnitine, GABA, D-serine) and an accompanying osmotic balance role (cell volume homeostasis, hypotonic salinity response). This unifying theme makes the label representative of the cluster's function. ","confidence":"High","size":19,"edges":48,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1902274","count":3},{"id":"GO:0097639","count":3},{"id":"GO:0006884","count":3},{"id":"GO:0035826","count":3},{"id":"GO:0097638","count":3}]},{"hash":"580546215598507678","title":"Developmental Morphogenesis and Cytoskeletal Regulation","description":"This cluster's GO terms cluster around developmental processes such as body morphogenesis, chitin-based cuticle development, and bone development, together with actin cytoskeleton organization and cell spreading. The inclusion of long-term synaptic depression and dendritic spine maintenance suggests cytoskeletal remodeling in neurons. Immune signaling and insulin pathway terms are present but less prevalent, so the core theme is developmental remodeling driven by cytoskeletal dynamics rather than a single pathway.","confidence":"Medium","size":19,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010171","count":3},{"id":"GO:0040003","count":3},{"id":"GO:0060292","count":3},{"id":"GO:0097062","count":2},{"id":"GO:0030036","count":2}]},{"hash":"1997408382452349952","title":"Iron metabolism and stress response","description":"This cluster centers on terms about iron ion transport, detoxification, and sequestration, with supporting signals from stress response and immune-related defense against bacteria. While some terms are obsolete, the common thread appears to be iron homeostasis coupled with cellular stress responses.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0048147","count":1},{"id":"GO:0006880","count":1},{"id":"GO:0006950","count":1}]},{"hash":"1174911611428835794","title":"Telomere Regulation and Neuronal Signaling","description":"The cluster includes several telomere maintenance-related terms (telomerase regulation, telomere capping, telomere length regulation) alongside neural development and signaling terms (Wnt signaling, ephrin signaling, cerebellar granule cell differentiation, synaptic receptor localization). This suggests a mixture of genome maintenance and neural signaling/differentiation processes, best captured by a name that reflects both themes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032212","count":4},{"id":"GO:1904355","count":4},{"id":"GO:0006397","count":4},{"id":"GO:1904357","count":3},{"id":"GO:0016055","count":3}]},{"hash":"279138863863634114","title":"Nervous system development and synapse formation","description":"The top GO terms strongly cluster around neural development and synaptic connectivity: nervous system development, positive regulation of synapse assembly, neuron migration, ventricular zone neuroblast division, and cell-cell adhesion. Kv channel clustering also ties to neuronal signaling, supporting a cohesive theme of neuronal development and synapse organization. A few terms like ossification and sarcomere organization appear peripheral but do not outweigh the neural emphasis.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0007156","count":5},{"id":"GO:0050910","count":5},{"id":"GO:0043931","count":5}]},{"hash":"2204935817181286857","title":"Embryonic organogenesis and tissue morphogenesis","description":"The terms cluster around development and morphogenesis across multiple organs (heart, placenta, eye, pituitary, habenula, prostate) and embryonic stages, with transcription by RNA polymerase II as a general background activity. This pattern points to genes involved in broad embryonic organ formation rather than a single tissue-specific process, so the name reflects the shared theme of developmental organogenesis.","confidence":"Medium","size":19,"edges":54,"triangles":34,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0048048","count":7},{"id":"GO:2000288","count":7},{"id":"GO:0021986","count":7},{"id":"GO:0060527","count":6}]},{"hash":"362194027171679193","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0030157","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0050909","count":3},{"id":"GO:0000480","count":3}]},{"hash":"718408344607457738","title":"Glutamatergic Synaptic Transmission","description":"The cluster's top GO terms strongly converge on excitatory synaptic signaling, including excitatory postsynaptic potential, ionotropic glutamate receptor signaling, and glutamatergic synaptic transmission, with receptor clustering and ion transport supporting these processes. This pattern points to proteins functioning at glutamatergic synapses and their signaling machinery, justifying the label.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":6},{"id":"GO:0010226","count":6},{"id":"GO:0035725","count":5},{"id":"GO:0060992","count":5},{"id":"GO:0071805","count":5}]},{"hash":"1792079518902903393","title":"Osteogenesis and osteoblast differentiation regulation","description":"This cluster\u2019s top GO terms center on bone development and ossification, including intramembranous ossification, cartilage condensation, and regulation of osteoblast differentiation, suggesting a shared role in bone formation. Additional terms point to cytoskeletal dynamics (Rho signaling, actin remodeling, GTPase activity) essential for osteoblast function and differentiation, while inflammatory mediator production can accompany bone remodeling. Although blood coagulation appears, the dominant theme ties to bone formation and osteoblast regulation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0001957","count":2},{"id":"GO:0045668","count":2},{"id":"GO:0007266","count":2}]},{"hash":"982380282144295680","title":"Vertebrate neural development and myelination","description":"This cluster centers on neural development and maturation, with multiple terms for axonal fasciculation, synapse assembly, corpus callosum development, and myelination, plus related signaling (RTK pathways, PI3K) and ECM organization (collagen fibril). While innate immune response appears, it may reflect glial roles during CNS development, but the dominant theme remains vertebrate neural development and myelination.","confidence":"High","size":19,"edges":3,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0032474","count":8},{"id":"GO:0007413","count":8},{"id":"GO:0051965","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0042552","count":8}]},{"hash":"2246833335335366715","title":"Neuronal signaling and sensory perception","description":"The cluster is dominated by GO terms related to neural signaling and sensory processing, including visual perception and learning, dopaminergic synaptic transmission, pain perception, cocaine-related behavioral responses, and ERK signaling; prostaglandin response adds a neuronal inflammatory signaling angle. A few terms (macrophage chemotaxis, heart development) are less directly connected, but the overall theme points to neuronal signaling and sensory function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071380","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0008542","count":5}]},{"hash":"1334738511100673834","title":"T cell activation and cytokine production","description":"This cluster shows a pattern of immune signaling terms: T cell costimulation, positive regulation of IL-2 and IL-4 production, regulation of dendritic cell differentiation, and regulation of macrophage activation, plus protein localization to cell junctions indicative of immune synapses and coreceptor-mediated interactions relevant to viral entry. Although one term mentions spermatid development, the dominant GO terms point to adaptive immune activation and cytokine regulation, justifying a label centered on T cell\u2013mediated signaling.","confidence":"High","size":19,"edges":18,"triangles":0,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":4},{"id":"GO:1904604","count":3},{"id":"GO:0051963","count":3},{"id":"GO:0045404","count":3},{"id":"GO:0043031","count":3}]},{"hash":"2148652881860568646","title":"Pain and Sensory Stress Response","description":"The cluster is dominated by sensory perception terms (pain, touch, cold) alongside multiple stress-response terms (osmotic, carbon monoxide, cardiac stress) and related signaling (immune modulation, development). While not pointing to a single precise pathway, the common theme is organismal response to environmental stimuli and stress, with nociception as a central element.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0007275","count":6},{"id":"GO:0071320","count":5},{"id":"GO:0009409","count":5},{"id":"GO:0002724","count":5}]},{"hash":"1594604475112605882","title":"Neural and Cardiovascular Development","description":"These proteins are heavily annotated with nervous system development, synapse assembly, and nerve impulse transmission, alongside heart development and angiogenesis, suggesting a developmental program coordinating neural and vascular/heart formation. The other terms (apoptotic/immune clearance and ovulation) appear less central to the dominant theme.","confidence":"High","size":19,"edges":161,"triangles":818,"max_degree":18,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":14},{"id":"GO:0051965","count":14},{"id":"GO:0042517","count":14},{"id":"GO:0007507","count":14},{"id":"GO:0097350","count":14}]},{"hash":"1313342837244640977","title":"Innate antiviral response and interferon signaling","description":"The top GO terms center on innate immunity and antiviral sensing (cellular response to type I interferon, innate immune response, response to virus, dsRNA sensing), implying participation in interferon-driven antiviral signaling. Some nonimmune terms reflect cross-species GO annotations but do not override the dominant antiviral theme.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071357","count":3},{"id":"GO:0042066","count":3},{"id":"GO:0009636","count":2},{"id":"GO:0008363","count":2},{"id":"GO:0008277","count":2}]},{"hash":"1479872623605076177","title":"RNA Processing and Translation Initiation","description":"This cluster shows strong representation of mRNA splicing, RNA processing, and components involved in forming the translation preinitiation complex and translation reinitiation, indicating a primary role in RNA maturation and initiation of protein synthesis; other terms like glutathione biosynthesis and proteolysis are peripheral.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0006750","count":2},{"id":"GO:0032298","count":2},{"id":"GO:0000055","count":2},{"id":"GO:1903026","count":2}]},{"hash":"1495471286949307484","title":"Dopamine GPCR\u2013cAMP Energy Signaling","description":"The terms cluster around dopamine-receptor\u2013mediated GPCR signaling, including activation of adenylate cyclase and PLC, and downstream cAMP and phosphatidylinositol pathways, plus energy-related processes like diet-induced thermogenesis and electron transport. This suggests a cohesive theme of GPCR-driven signaling that regulates energy expenditure and metabolism via dopamine pathways.","confidence":"Medium","size":19,"edges":8,"triangles":2,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0045777","count":7},{"id":"GO:0007190","count":7}]},{"hash":"1429858332067154751","title":"Golgi\u2013endosome\u2013vacuole trafficking and MVB sorting","description":"The top GO terms point to intracellular trafficking within the endomembrane system: transport between the Golgi, endosomes, and vacuole, along with endocytosis and multivesicular body sorting pathways. These collectively suggest a vesicle trafficking and cargo-sorting cluster toward the vacuole/lysosome. Some terms (e.g., female pregnancy, cardioblast fate) are likely unrelated annotations, but the core signal is clear. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006623","count":2},{"id":"GO:0006895","count":2},{"id":"GO:0009997","count":2},{"id":"GO:0034498","count":2},{"id":"GO:0006897","count":2}]},{"hash":"2044661874238249475","title":"Transmembrane Ion and Metabolite Transporters","description":"This cluster is characterized by a strong enrichment for transmembrane transport GO terms covering ions (sodium, potassium), nitrite, sialic acid, galactose, vitamin, and other small molecules, plus xenobiotic transport and related substrate transport. The common theme among these proteins appears to be membrane transport activity with diverse substrates, rather than catalytic or signaling roles.","confidence":"High","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:1900754","count":3},{"id":"GO:0015707","count":3},{"id":"GO:0006855","count":3}]},{"hash":"219881766939607722","title":"Neuronal development and signaling","description":"This cluster centers on neural development and communication: neuron migration, synapse assembly, and cell maturation, along with signaling pathways such as GPCR-coupled adenylate cyclase activation and Rho-mediated signaling. Although several terms touch vascular processes (blood pressure regulation, anti-angiogenic/VEGF signaling), the strongest signal is neuronal development and neuronal signaling; metabolic terms like electron transport chain may reflect general cellular energy requirements in developing neurons.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":15},{"id":"GO:0010579","count":15},{"id":"GO:0022900","count":15},{"id":"GO:0035025","count":10},{"id":"GO:0051965","count":9}]},{"hash":"1594691877539286148","title":"Unknown","description":"The top GO terms are extremely diverse, covering transcription, cell division, septum digestion after cytokinesis, pigmentation, mating/conjugation, neural development, ER-Golgi vesicle transport, GTPase regulation, and ribosome biogenesis. There is no clear unifying function or pathway across most of the proteins, and the cluster has no edges, suggesting limited functional cohesion. Without a common theme, a precise, concise label cannot be confidently assigned.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0000920","count":2},{"id":"GO:0043473","count":2},{"id":"GO:0000747","count":2}]},{"hash":"947069993303874189","title":"Embryonic morphogenesis and organ development","description":"The top GO terms cluster around developmental processes: cartilage morphogenesis, left-right pattern formation, placental and endocrine system development, and EMT in heart formation, indicating a focus on embryogenesis and organogenesis rather than a single pathway or function.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":10},{"id":"GO:0060972","count":10},{"id":"GO:0060707","count":10},{"id":"GO:0035270","count":10},{"id":"GO:0060806","count":10}]},{"hash":"776758788064920844","title":"Neural development and ECM remodeling","description":"This cluster is dominated by neural development terms (spinal cord, midbrain, brain development) and extracellular matrix remodeling (collagen fibril organization), with supporting processes such as receptor-mediated endocytosis and apoptotic cell clearance that occur during tissue morphogenesis; immune-related terms appear as part of developmental clearance, so the overall theme fits neural development with ECM remodeling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":4},{"id":"GO:0021510","count":4},{"id":"GO:0006898","count":4},{"id":"GO:0000122","count":3},{"id":"GO:0007275","count":3}]},{"hash":"479038322454728202","title":"Cardiovascular GPCR-cAMP signaling and vascular regulation","description":"The cluster is dominated by GO terms for adenylate cyclase-activating GPCR signaling and activation of adenylate cyclase, which feed into vascular effects such as blood pressure regulation and vascular permeability, as well as prostaglandin-related signaling and smooth muscle relaxation. While there are a few terms related to temperature response, pain, and energy metabolism, the strongest and most representative theme is GPCR-cAMP\u2013mediated signaling impacting cardiovascular and vascular functions.","confidence":"Medium","size":19,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":17},{"id":"GO:0007190","count":17},{"id":"GO:0022900","count":17},{"id":"GO:0045777","count":17},{"id":"GO:0071502","count":16}]},{"hash":"702272236349723148","title":"Cardiovascular Regulation and Metabolic Signaling","description":"The Top Terms point to cardiovascular homeostasis (blood pressure regulation, vascular permeability, muscle relaxation), GPCR-AC signaling, prostaglandin- and thermogenic responses, and energy metabolism (electron transport). The mix of immune and pain-related terms suggests broad regulatory signaling rather than a single pathway, so the label reflects a cluster centered on cardiovascular/metabolic regulation with supporting signals.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":12},{"id":"GO:0010579","count":12},{"id":"GO:0022900","count":12},{"id":"GO:0071502","count":10},{"id":"GO:0019233","count":10}]},{"hash":"388415952865864655","title":"Unknown","description":"This set shows a mixture of GO terms spanning immune signaling (adaptive immune response, antigen processing via MHC I, Fc-epsilon receptor signaling), neuronal development (branchiomotor axon guidance, sympathetic neuron projection guidance, axonal fasciculation), transcription, kinase activation, cell cycle, and metal stress response (cadmium). The absence of a single dominant function or pathway among the top terms, along with low connectivity, suggests no cohesive unifying theme to label the cluster with high confidence.","confidence":"","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0032147","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0002479","count":2},{"id":"GO:0046686","count":2}]},{"hash":"1170488763092519013","title":"Nematode Molting and Development","description":"This cluster's top GO terms center on nematode development: molting cycle and cuticle formation, pharyngeal pumping, and female gamete generation, with core cell-cycle and DNA replication processes. Together they suggest proteins involved in nematode growth and reproduction, where cell-cycle control underpins proliferation during development. A few terms (vitamin K response; chemokine production) are less clearly connected and may reflect broader regulatory contexts.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0043050","count":1},{"id":"GO:0007155","count":1},{"id":"GO:0071307","count":1}]},{"hash":"92637218819046485","title":"Plant photoreception and retinal carotenoid metabolism","description":"The cluster centers on retinal/retinoid pathway terms (vitamin A, retinal metabolism, xanthophyll catabolism) and light-sensing processes (phototransduction, visual perception, retina homeostasis), with plant-specific links to light-regulated development (strigolactone biosynthesis, secondary shoot formation). This points to a cohesive theme of light signaling via carotenoid-derived molecules influencing plant development.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901601","count":1},{"id":"GO:0035238","count":1},{"id":"GO:0016124","count":1},{"id":"GO:0042574","count":1},{"id":"GO:0007604","count":1}]},{"hash":"1714780667740280165","title":"Transcription Regulation Cluster","description":"Most terms cluster around transcription: DNA-templated transcription (GO:0006351) and positive regulation of transcription elongation by RNA polymerase II (GO:0032968), with additional related terms like DNA integration and general regulation of transcription. While some GO terms touch on unrelated areas (placenta development, muscle development, metabolism), the strongest and most represented theme is transcriptional control and transcriptional elongation. Therefore, label as Transcription Regulation Cluster.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0001890","count":2},{"id":"GO:0009636","count":2},{"id":"GO:2000114","count":2},{"id":"GO:0090180","count":2}]},{"hash":"13171855600059251","title":"Ion Transport and Neurotransmission","description":"This cluster centers on ion transport (sodium, potassium, calcium) and the ionotropic glutamate receptor signaling pathway, with supporting terms like serotonin metabolism and locomotion/sensory development. Together, these suggest a cohesive theme of neuronal signaling mediated by ion channels and neurotransmitter receptors, underlining movement and sensory processing roles.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042428","count":1},{"id":"GO:0035176","count":1},{"id":"GO:0010157","count":1},{"id":"GO:0035725","count":1},{"id":"GO:0043056","count":1}]},{"hash":"1659705994219616469","title":"Cell Signaling and Development Pathways","description":"The top GO terms point to multiple signal transduction cascades (MAPK, ephrin, PDGF signaling) and tissue development (skeletal muscle, thyroid, brown fat differentiation). Although there are a few unrelated terms like DNA integration, the dominant pattern is engagement in signaling and developmental processes across different cell types, suggesting the cluster represents proteins involved in broad signaling and developmental roles rather than a single pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0050853","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0030878","count":1},{"id":"GO:0071507","count":1}]},{"hash":"1096217584719658188","title":"Autophagy and vesicle trafficking","description":"The cluster shows several autophagy-related terms (autophagosome assembly, macroautophagy, mitophagy) alongside vesicle trafficking components (SNARE complex assembly, maintenance of Golgi location), suggesting proteins linked to autophagy-driven vesicle formation and trafficking. Some terms (e.g., DNA repair) may be less directly connected, but the autophagy/vesicle trafficking theme is the strongest pattern across the top terms.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035493","count":1},{"id":"GO:0042149","count":1},{"id":"GO:0098779","count":1},{"id":"GO:0090207","count":1},{"id":"GO:0051684","count":1}]},{"hash":"1820066120160870651","title":"Neuronal signaling and behavior regulation","description":"The top GO terms cluster around neural activity and behavior: exploration and startle responses, social and vocalization behaviors, along with ion channel\u2013mediated sodium/potassium transport, synaptic plasticity (long-term depression), receptor clustering, and regulation of protein localization to the cell surface. Together these indicate a cohesive role in neuronal signaling and the modulation of behavioral outputs, particularly social/communication behaviors.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035641","count":2},{"id":"GO:0001964","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2}]},{"hash":"569012365158924663","title":"Rho GTPase-driven actin remodeling and cell polarity","description":"The cluster centers on actin cytoskeleton remodeling and cell polarity, driven by Rho GTPase regulation and microspike assembly, with supportive signals from T cell signaling and thymus development indicating immune context.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0030035","count":2},{"id":"GO:1900026","count":2},{"id":"GO:0048538","count":2}]},{"hash":"978415047481558137","title":"Unknown","description":"The set mixes neural development (myelination, otolith morphogenesis, branching morphogenesis of a nerve), extracellular matrix processes (collagen fibril organization and its negative regulation), and even plant hormone signaling (brassinosteroid detection), with only a single immune signaling term and no clear shared pathway. With no consistent theme or connectivity across the GO terms, a single, coherent label cannot be assigned beyond Unknown.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0060011","count":1},{"id":"GO:0030199","count":1},{"id":"GO:0051770","count":1},{"id":"GO:0002755","count":1}]},{"hash":"2234111622240342140","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":124,"triangles":429,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":14},{"id":"GO:0098789","count":1},{"id":"GO:0006378","count":1},{"id":"GO:0006398","count":1},{"id":"GO:0035307","count":1}]},{"hash":"1148563363683936031","title":"Larval chitin-based cuticle development","description":"The cluster is strongly dominated by the GO term for larval chitin-based cuticle development, suggesting the proteins largely participate in insect cuticle formation during larval stages. The other terms appear as sparse outliers (e.g., immune and other developmental processes), likely incidental annotations. Overall, the primary cohesive function aligns with insect larval cuticle biosynthesis/development.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":15},{"id":"GO:0050832","count":1},{"id":"GO:0007596","count":1},{"id":"GO:1900738","count":1},{"id":"GO:0009791","count":1}]},{"hash":"554384719311197442","title":"Neuronal development and synapse formation","description":"The cluster shows strong enrichment for axon guidance, dendritic spine morphogenesis, protein localization to synapse, and receptor clustering, all key processes in neuronal development and synapse organization. Rho signaling and cell-matrix adhesion further support cytoskeletal dynamics and adhesion required for neurite outgrowth and synaptic assembly; although heart development and growth hormone signaling appear, they are less central to the dominant neuronal/synaptic theme.","confidence":"High","size":18,"edges":32,"triangles":16,"max_degree":8,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0046827","count":9},{"id":"GO:0060396","count":9},{"id":"GO:0008045","count":9},{"id":"GO:0043113","count":9},{"id":"GO:0060997","count":9}]},{"hash":"1939013842595743428","title":"Developmental Signaling and Cellular Regulation","description":"This cluster merges terms across development (spinal cord development, multicellular growth), signaling regulation (protein autophosphorylation, serine/threonine kinase activity, GTPase activity), cell cycle and structure (mitotic cell cycle, cilium assembly), plus roles in RNA transport and stress responses (hypoxia) and even defense. The proteins likely participate in broad regulatory networks coordinating growth, differentiation, and signaling rather than a single specific pathway, so a general developmental signaling and regulation label fits best.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050830","count":4},{"id":"GO:0035264","count":4},{"id":"GO:0031954","count":4},{"id":"GO:0021510","count":4},{"id":"GO:0043547","count":4}]},{"hash":"485720640978366260","title":"Complement and Coagulation in Immunity","description":"Based on the prominent GO terms, the proteins cluster around innate immune activation and hemostasis: lectin pathway complement activation, blood coagulation/fibrin clot formation, adaptive immune response, and TNF signaling. These collectively point to an immune-coagulation functional theme, with some peripheral terms (oxidation-reduction, sarcomere organization, calcium release) likely representing broader signaling or background noise. Confidence: Medium","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":2},{"id":"GO:0007171","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0072378","count":2},{"id":"GO:1903265","count":2}]},{"hash":"2024867512865596780","title":"Fungal-Triggered Innate Immune Signaling","description":"The top terms point to innate immune pathways activated by fungal components, including cellular response to fungal origin, lectin pathway complement activation, C-type lectin receptor signaling, and Fc-gamma receptor signaling. NK cell chemotaxis regulation and lymph vessel morphogenesis suggest allied immune surveillance and tissue remodeling. Overall, the cluster centers on innate recognition and signaling in response to fungal molecules, with some developmental terms likely representing annotation noise.","confidence":"High","size":18,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":12},{"id":"GO:0001867","count":11},{"id":"GO:0072218","count":9},{"id":"GO:0051873","count":9},{"id":"GO:0036303","count":9}]},{"hash":"1257928313080727826","title":"Membrane trafficking and cell polarity","description":"The top GO terms cluster around vesicle transport and membrane remodeling (COPI coating, vesicle transport, membrane tubulation, small GTPase signaling) along with processes linked to establishing epithelial polarity and actin-rich structures (podosome assembly). This suggests a coherent theme of membrane trafficking and polarity regulation, despite a few outlier terms such as cuticle development and rhythmicity that may reflect species-specific or peripheral roles. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0070142","count":1},{"id":"GO:1903527","count":1},{"id":"GO:0097284","count":1},{"id":"GO:0090162","count":1}]},{"hash":"376228378197405582","title":"Innate Immune Response and Inflammation","description":"This cluster\u2019s top GO terms cluster around innate immune defense, antiviral response, and inflammatory mediator production, with chemokine regulation as a common thread. While other terms are present, the strongest and most cohesive theme is innate immunity and inflammation, justifying this label. The absence of edges suggests possible dispersed roles or multifunctionality rather than a tightly connected module.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0002532","count":2}]},{"hash":"503600314312273224","title":"Organogenesis and immune signaling","description":"The proteins here link developmental and morphogenetic processes (multicellular organism development, planar polarity, outer ear morphogenesis, glomerular basement membrane development, angiogenesis) with immune-related activities (complement activation, dendritic cell cytokine production, GM-CSF production, response to muramyl dipeptide). This suggests a cluster of factors coordinating tissue development with immune signaling rather than a single uni\ufb01ed pathway. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0032836","count":3},{"id":"GO:0043552","count":2},{"id":"GO:0001736","count":2}]},{"hash":"706138501248221772","title":"Unknown","description":"The top GO terms cover a broad range of processes (polarity in epithelial tissue, neuron maturation, actin severing, chromatin localization, innate immune signaling, ubiquitination, various signaling pathways, and mitosis control) with no single cohesive theme. This diversity suggests no specific, common function defining this protein set, so a precise label cannot be confidently assigned.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016336","count":2},{"id":"GO:0014041","count":2},{"id":"GO:0051014","count":2},{"id":"GO:0071169","count":2},{"id":"GO:0002755","count":2}]},{"hash":"120194129715666099","title":"Endochondral cartilage and skeletal development","description":"The top GO terms cluster around cartilage and bone morphogenesis (endochondral bone morphogenesis, growth plate cartilage chondrocyte development, collagen fibril organization, cartilage development), indicating a skeletal/cartilage development program. A few digestive terms are present but seem peripheral to the main theme. ","confidence":"High","size":18,"edges":61,"triangles":109,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0044258","count":2},{"id":"GO:0018350","count":2},{"id":"GO:0030157","count":2},{"id":"GO:0030199","count":1},{"id":"GO:0051873","count":1}]},{"hash":"1551706456995218771","title":"Glutamatergic synaptic regulation in pain and learning","description":"Most terms cluster around glutamatergic synaptic function (transmission, receptor internalization, regulation), coupled with pain regulation, sensory perception, learning and cognitive modulation (visual learning, prepulse inhibition), and serotonin-related pathways. This points to a coherent theme of neuronal signaling in glutamatergic circuits governing pain perception and learning behaviors.","confidence":"High","size":18,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":3},{"id":"GO:0051967","count":3},{"id":"GO:0031623","count":3},{"id":"GO:0051930","count":3},{"id":"GO:0001975","count":3}]},{"hash":"1665304127409563605","title":"Epithelial Polarity and Cell Migration","description":"The cluster is dominated by GO terms for establishing epithelial cell polarity, actin filament bundle assembly, and cell migration, with supporting signals from Wnt signaling. Together these point to coordinated control of cell shape, cytoskeletal remodeling, and movement typical of epithelial cells undergoing morphogenesis or migration. The other terms (e.g., telomere maintenance regulation, heart conduction) appear less central to the core theme and may reflect broader or noisy annotations. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0016477","count":3},{"id":"GO:1904357","count":2},{"id":"GO:0070682","count":2}]},{"hash":"1921206257269579085","title":"Embryonic Development and Cell Cycle","description":"This cluster centers on developmental processes (multicellular organism development, neural tube closure, skeletal system development) together with core cell cycle and transcriptional control (DNA-templated transcription, mitotic cell cycle, cell division). The dominant signals point to programs governing development and proliferation; occasional stress/defense terms appear less central. ","confidence":"Medium","size":18,"edges":4,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001403","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0001501","count":4}]},{"hash":"616048964807294233","title":"Transcription and Chromatin Regulation","description":"The cluster is enriched for DNA-templated transcription and its regulation, along with ribosome biogenesis, and even histone methylation terms (notably obsolete H3-K4 and H3-K79 methylation). This pattern points to nuclear gene expression machinery and chromatin remodeling as the core theme. Some inflammatory, metabolic, and sensory-taste terms appear, but they seem less coherent with the main theme and may reflect annotation noise.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0051568","count":2},{"id":"GO:0034729","count":2},{"id":"GO:0006355","count":2}]},{"hash":"1145756621078430243","title":"Larval chitin-based cuticle development","description":"This cluster is dominated by GO:0008363, larval chitin-based cuticle development, suggesting proteins participate in formation or remodeling of the insect larval chitinous cuticle. The high count (17 annotations) indicates a cohesive, specialized function in the larval exoskeleton.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":17}]},{"hash":"1630800054455916158","title":"GTPase-driven filopodium assembly","description":"This cluster centers on small GTPase-mediated signaling and the assembly/regulation of filopodia, pointing to actin cytoskeleton remodeling and protrusion formation as the core shared function. While there are additional developmental terms (fertilization, hair follicle morphogenesis, spermatogenesis) and membrane-related processes (endocytosis, mechanotransduction), the strongest common thread is signaling that drives filopodium formation and cytoskeletal dynamics.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":3},{"id":"GO:0051489","count":3},{"id":"GO:0046847","count":3},{"id":"GO:0043497","count":2},{"id":"GO:0009566","count":2}]},{"hash":"204578215964725266","title":"Embryonic development and morphogenesis","description":"These terms cluster around embryonic development and tissue morphogenesis (mesoderm development, cartilage morphogenesis, left-right patterning, palate formation, trophoblast differentiation). While some regulatory terms appear, the dominant theme is developmental patterning and morphogenesis, suggesting these proteins share roles in developmental processes rather than a single catalytic function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060625","count":1},{"id":"GO:0007252","count":1},{"id":"GO:0060536","count":1},{"id":"GO:0060972","count":1},{"id":"GO:0007498","count":1}]},{"hash":"863280685415471106","title":"Larval chitin-based cuticle development","description":"All 18 proteins are annotated with GO:0008363, larval chitin-based cuticle development, indicating this cluster is strongly associated with formation or remodeling of the larval cuticle composed of chitin. The dense interaction network (153 edges, 816 triangles) supports a cohesive module likely consisting of cuticle structural proteins and enzymes involved in chitin synthesis or remodeling, typical of insect larval development.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":18}]},{"hash":"823950270402792700","title":"Larval chitin-based cuticle development","description":"The top term is larval chitin-based cuticle development (GO:0008363) with six proteins, indicating the cluster is mainly involved in larval cuticle formation. The other GO terms (nervous system development, neuron migration, etc.) appear at low frequencies, suggesting secondary or broader developmental roles. Therefore, the dominant theme is larval cuticle development, with ancillary associations to other developmental processes.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":6},{"id":"GO:0043524","count":1},{"id":"GO:0014707","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0031098","count":1}]},{"hash":"1147079280946699652","title":"Circadian locomotor rhythm and sleep wake regulation","description":"The terms converge on circadian control of behavior and movement\u2014circadian and sleep/wake cycle regulation, locomotor rhythm, and entrainment by photoperiod\u2014along with GPCR signaling that modulates these clocks, suggesting a cluster of proteins involved in circadian-driven locomotion and behavior. Gravitaxis and mating behavior also relate to movement- and time-linked behavioral outputs, reinforcing this theme.","confidence":"High","size":18,"edges":48,"triangles":24,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0010579","count":4},{"id":"GO:0042332","count":4},{"id":"GO:1904059","count":4},{"id":"GO:0010841","count":4},{"id":"GO:0042745","count":4}]},{"hash":"1048327814006975297","title":"Plant cell wall biosynthesis and glycosylation","description":"The top GO terms cluster around plant cell wall polysaccharide production (glucuronoxylan and homogalacturonan biosynthesis, mucilage biosynthesis, plant-type secondary cell wall biogenesis, and overall cell wall organization) and related O-linked glycosylation processes (via GalNAc and mannose) and galactose metabolism, indicating a cohesive theme of wall biosynthesis and sugar modifications in plants.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010417","count":3},{"id":"GO:0071555","count":3},{"id":"GO:0010289","count":3},{"id":"GO:0016266","count":3},{"id":"GO:0010192","count":3}]},{"hash":"848711395731231107","title":"Neural development and axon guidance signaling","description":"The top GO terms cluster around nervous system development, axon guidance (Roundabout), and neuronal signaling processes such as synaptic vesicle exocytosis and ERK signaling, with Hedgehog (Smoothened) involvement. This suggests a shared theme of neural development and signaling rather than immune or mating pathways, despite a few outlier terms. ","confidence":"Medium","size":18,"edges":134,"triangles":558,"max_degree":17,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007399","count":8},{"id":"GO:0050852","count":8},{"id":"GO:0035385","count":8},{"id":"GO:0010796","count":7},{"id":"GO:0031384","count":7}]},{"hash":"1844476988052161896","title":"Glutamatergic Synaptic Plasticity Regulation","description":"This cluster centers on modulation of glutamatergic signaling and plasticity, with terms for NMDA receptor clustering, AMPA receptor activity, long-term potentiation, and positive regulation of phosphorylation and kinase activity. The shared theme is proteins that enhance receptor signaling and synaptic strength, aligning well with a glutamatergic plasticity module; the amphetamine response term may reflect broader synaptic regulation. ","confidence":"High","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0050731","count":4},{"id":"GO:0031954","count":3},{"id":"GO:0001975","count":3},{"id":"GO:0071902","count":3}]},{"hash":"2148159467432089303","title":"ER Network and Nuclear Envelope Dynamics","description":"This cluster groups proteins involved in ER organization (inheritance, tubular networks, general organization), ER stress response, ER-dependent peroxisome organization, and nuclear envelope/nuclear pore assembly, all pointing to ER-driven membrane architecture and trafficking; the taste-related terms are likely incidental. ","confidence":"High","size":18,"edges":27,"triangles":10,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0048309","count":2},{"id":"GO:0034976","count":2},{"id":"GO:0051292","count":2},{"id":"GO:0050916","count":2},{"id":"GO:0007084","count":2}]},{"hash":"2280232217601336957","title":"Axon Guidance and Synapse Formation","description":"This cluster centers on neural development and synaptic organization: motor neuron axon guidance, dendritic spine morphogenesis, receptor clustering and localization to synapse, and Rho-mediated cytoskeletal remodeling, all pointing to axon pathfinding and synapse assembly; auxiliary terms like growth hormone and glucocorticoid signaling may modulate neuronal function, while outliers such as heart development are less directly tied but do not dominate the theme.","confidence":"Medium","size":18,"edges":9,"triangles":0,"max_degree":5,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0008045","count":6},{"id":"GO:0060396","count":6},{"id":"GO:0043113","count":6},{"id":"GO:0007160","count":6},{"id":"GO:2000324","count":5}]},{"hash":"110569704260622154","title":"Ubiquitin-dependent immune regulation","description":"The top GO terms cluster around ubiquitin-dependent protein catabolic processes and immune-regulatory roles (mast cell cytokine production, dendritic cell differentiation, IgE isotype regulation, and specific ubiquitin linkages), suggesting these proteins function together in ubiquitin-mediated modulation of immune signaling and protein turnover.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0032764","count":8},{"id":"GO:2000312","count":8},{"id":"GO:1904431","count":8},{"id":"GO:0045497","count":8}]},{"hash":"2083722235719844226","title":"Neural signaling and sensory processing","description":"The Top Terms cluster around neuronal activity, synaptic transmission (excitatory postsynaptic potential), and sensory responses (sound perception, startle, locomotion), with supporting roles for ion transport (sodium and calcium) that drive excitability. There is a developmental note with optic nerve morphogenesis, but the dominant pattern is neural signaling and sensory processing.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071361","count":14},{"id":"GO:0007626","count":14},{"id":"GO:0042220","count":14},{"id":"GO:0060079","count":14},{"id":"GO:1901214","count":14}]},{"hash":"1380093796625527390","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":56,"triangles":108,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":8},{"id":"GO:0016120","count":7},{"id":"GO:0098908","count":6},{"id":"GO:2000627","count":6},{"id":"GO:0045716","count":6}]},{"hash":"385075789625816647","title":"Aromatic compound metabolism and detoxification","description":"Top GO terms point to metabolic and catabolic processes, especially processing of aromatic compounds and xenobiotics (beta-ketoadipate pathway, stilbene and 1,2-dichloroethane catabolic), along with detoxification (cellular oxidant detoxification) and secondary metabolite metabolism (alkaloid). A few terms relate to plant development, which may be incidental. The common thread is enzymes involved in metabolism and breakdown of complex organic molecules and detox pathways, suggesting the cluster reflects Aromatic compound metabolism and detoxification.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006526","count":2},{"id":"GO:0045471","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0046272","count":2},{"id":"GO:0010223","count":2}]},{"hash":"1733764287619490180","title":"Vacuolar amino acid import/export","description":"The terms are centered on transmembrane transport across the vacuolar membrane for several amino acids (glutamate, serine, histidine, arginine, alanine) and an amino acid export term, plus related ion transport and a potassium starvation response. This suggests a cohesive theme of vacuolar amino acid trafficking, with one unrelated term (root cap development) that does not fit the main pattern. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016311","count":1},{"id":"GO:0048829","count":1},{"id":"GO:0090515","count":1},{"id":"GO:0090516","count":1},{"id":"GO:0089708","count":1}]},{"hash":"1688365381465617233","title":"Lipid biosynthesis and immune signaling","description":"Many top GO terms point to lipid metabolism: CDP-diacylglycerol biosynthesis, phosphatidylcholine and ether lipid biosynthesis, cholesterol homeostasis, and cardiolipin remodeling, plus platelet activating factor biosynthesis. There are also immune-related terms like cellular response to lipopolysaccharide and interleukin-2 production, suggesting a link between lipid mediator production and immune activation. A few development terms (vagina development, glandular epithelial cell maturation) are present but appear secondary to the lipid/immune theme. Overall, the cluster seems best characterized by lipid metabolism with accompanying immune signaling.","confidence":"Medium","size":18,"edges":17,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0042632","count":3},{"id":"GO:0060068","count":3},{"id":"GO:0016024","count":3},{"id":"GO:0002071","count":3}]},{"hash":"2112397872691875063","title":"Neuronal development and synaptic organization","description":"The terms cluster around neuronal differentiation, synaptic assembly (neuroligin clustering and postsynaptic membrane organization), and signaling pathways (Wnt, GTPase, JNK) that influence neuron development and synapse formation, with apoptosis as a related neuronal fate process.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0030182","count":2}]},{"hash":"1049216765052689796","title":"Dopamine/Adrenergic GPCR-cAMP Signaling","description":"These proteins partner in GPCR-mediated signaling that activates adenylate cyclase and raises cAMP, including dopamine- and adrenergic-receptor pathways, with positive regulation of blood pressure. Additional terms point to phospholipase C\u2013activating signaling and phosphatidylinositol biosynthesis, consistent with GPCR cascades converging on multiple second-messenger pathways. The presence of an electron transport chain term is likely ancillary. Overall, the cluster centers on dopamine/adrenergic GPCR-cAMP signaling and vascular tone regulation.","confidence":"High","size":18,"edges":18,"triangles":6,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":17},{"id":"GO:0060158","count":17},{"id":"GO:0010513","count":17},{"id":"GO:0007190","count":17},{"id":"GO:0010579","count":17}]},{"hash":"232573878582090433","title":"Neural and Visual Development Signaling","description":"This cluster shows strong ties to development and signaling in nervous and visual systems, with terms like nervous system development, visual perception, and regulation of signaling pathways (ERK/MAPK and Wnt), plus related processes such as angiogenesis and heart development. The shared theme appears to be proteins that modulate developmental signaling networks across multiple tissues, including neural/eye-related functions, with additional vascular and cardiac development cues.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0007507","count":5}]},{"hash":"219744755885164766","title":"Proteolysis and Developmental Signaling","description":"The terms cluster around protein turnover (proteolysis, proteasome regulatory particle assembly, protein dephosphorylation) and signaling pathways (Wnt signaling, vitamin D response, chemokine production), with developmental contexts (spermatid development, establishment of epithelial cell polarity). This suggests a theme of proteolysis-regulated signaling during development and differentiation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0007286","count":2},{"id":"GO:1904357","count":2},{"id":"GO:0090162","count":2}]},{"hash":"1374466821629959175","title":"Hepatic regeneration and coagulation regulation","description":"The set of GO terms centers on liver-related processes (liver regeneration, hepatocyte proliferation regulation, insulin processing) and coagulation/hemostasis (blood coagulation, fibrinolysis, bradykinin catabolic process, angiotensin regulation). Together they suggest a module tied to liver maintenance and remodeling of the extracellular matrix, with coordinated control of blood coagulation and vascular tone.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000346","count":2},{"id":"GO:0035609","count":2},{"id":"GO:0097421","count":2},{"id":"GO:0035611","count":2},{"id":"GO:0003331","count":2}]},{"hash":"2113270369223451091","title":"Embryonic Morphogenesis","description":"The proteins are tagged with a range of developmental and morphogenesis-related GO terms\u2014pancreatic cell development, mesoderm formation, cartilage morphogenesis, palate development, left-right patterning, and trophoblast differentiation\u2014suggesting a broad embryonic morphogenesis role rather than a single pathway. While some metabolic and transcription-regulation terms appear, the dominant signal is tissue and organ morphogenesis in development.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0003323","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0005975","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0060972","count":3}]},{"hash":"2250592048389125393","title":"Unknown","description":"The GO terms are scattered across diverse developmental and cellular processes (pancreatic and endocrine development, cartilage morphogenesis, EMT), plus ubiquitination-related and even obsolete terms, with no coherent shared function. With Edges 0 and Max Degree 0, there\u2019s no apparent connectivity to justify a specific label, so \u201cUnknown\u201d best fits.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":10},{"id":"GO:0032764","count":8},{"id":"GO:0042787","count":8},{"id":"GO:2000312","count":8},{"id":"GO:0035270","count":8}]},{"hash":"1528891257908115537","title":"Glutamatergic signaling and neuronal ion transport","description":"This cluster is dominated by neural function terms: sodium, potassium, and calcium ion transport; ionotropic glutamate receptor signaling; and long-term synaptic depression, all core to neuronal excitability and synaptic plasticity. Connections to forward locomotion and social behavior suggest involvement in neural circuits of movement and interaction, while anterior lateral line development indicates sensory-neural development in some species. The combination of ion transport and glutamatergic signaling supports a cohesive theme of neuronal signaling and synaptic communication.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":5},{"id":"GO:0071805","count":5},{"id":"GO:0035176","count":5},{"id":"GO:0060292","count":5},{"id":"GO:0042428","count":4}]},{"hash":"2218527829189805169","title":"Unknown","description":"The top GO terms span several unrelated differentiation processes (dendritic cells, photoreceptors, skeletal muscle, glial cells) and a mix of signaling and protein turnover activities, with no clear common function. There are no edges in the cluster, and only 2 proteins were re-added, providing little evidence of a cohesive biological role. Thus a specific, representative label cannot be determined.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":2},{"id":"GO:0046533","count":2},{"id":"GO:0035914","count":2},{"id":"GO:0014009","count":2},{"id":"GO:0032392","count":2}]},{"hash":"1439800599748599285","title":"Embryonic organ morphogenesis","description":"The GO terms point to developmental processes governing organ formation during embryogenesis, especially heart morphogenesis, left/right patterning, cartilage development, placenta-related differentiation, and endocrine system development, indicating a cohesive theme of embryonic organ formation; a few terms like mRNA splicing and cellular senescence are more general regulatory processes observed in development.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0060806","count":2}]},{"hash":"568994184847864223","title":"Signaling and stress responses","description":"These proteins show enrichment across a range of signaling and stimulus-response processes, including Wnt signaling, GPCR-related signaling, and chemokine production, as well as responses to mechanical stimulus, cold, and vitamin D. Additional terms related to cell polarity, proteasome assembly, and telomere maintenance suggest broader regulation of cellular state and protein turnover under stress or changing conditions. While there isn\u2019t a single dominant pathway, the common thread is involvement in signaling networks and adaptive responses to internal and external cues. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":7},{"id":"GO:0033280","count":7},{"id":"GO:0048549","count":6},{"id":"GO:0007205","count":6},{"id":"GO:1904357","count":5}]},{"hash":"2170762545237310242","title":"Photoreceptor synapse and cytoskeletal signaling","description":"The cluster is dominated by GO terms for synapse organization, actin cytoskeleton organization, and light-stimulus signaling (including receptor guanylyl cyclase signaling and light perception). These collectively point to photoreceptor synaptic function and the associated cytoskeletal remodeling that supports signal transmission, with supportive Rho and dephosphorylation signaling an integrated regulatory layer.","confidence":"High","size":17,"edges":38,"triangles":32,"max_degree":13,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0050808","count":11},{"id":"GO:0035023","count":11},{"id":"GO:0006508","count":8},{"id":"GO:0035234","count":8},{"id":"GO:0007168","count":7}]},{"hash":"659980366963579","title":"Unknown","description":"The top GO terms span DNA replication and cell-cycle transitions, developmental processes (lung and mesoderm), steroid metabolism (androgen, testosterone biosynthesis), intracellular trafficking (ER to Golgi transport), and several diverse metabolic pathways. This mixture does not point to a single coherent function or pathway characterizing the entire cluster, so a single intuitive label is not apparent.","confidence":"","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0000082","count":2},{"id":"GO:0030324","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0061587","count":2}]},{"hash":"1772318279745545373","title":"Golgi-Driven Vesicle Trafficking and Synaptic Receptor Localization","description":"The top GO terms point to Golgi-centric vesicle trafficking (SNARE assembly, intra-Golgi and ER-Golgi transport, Golgi ribbon formation) and to postsynaptic receptor localization and synaptic potentiation, suggesting a coordinated role in delivering receptors via the Golgi to synapses.","confidence":"High","size":17,"edges":68,"triangles":74,"max_degree":14,"top_function":"vesicle-mediated transport","top_go_terms":[{"id":"GO:0048280","count":9},{"id":"GO:0035493","count":8},{"id":"GO:0006891","count":8},{"id":"GO:0090161","count":8},{"id":"GO:0060291","count":8}]},{"hash":"1387079630592946149","title":"RNA processing and mRNA surveillance","description":"The top terms cluster around RNA maturation and quality control: translation, spliceosome-mediated splicing, mRNA export, snRNP assembly, tRNA processing, and several mRNA decay/surveillance pathways (no-go decay, non-stop decay). This suggests a cohesive group of proteins involved in RNA processing and mRNA turnover, with related links to protein quality control (aggresome) through shared cellular quality-control pathways. Overall, the dominant theme is RNA processing and surveillance with connected quality-control facets.","confidence":"High","size":17,"edges":77,"triangles":171,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0045292","count":5},{"id":"GO:0030433","count":3},{"id":"GO:0006406","count":3},{"id":"GO:0000387","count":3}]},{"hash":"334575127851248161","title":"Chromatin assembly and remodeling","description":"Most terms point to chromatin organization\u2014nucleosome assembly, histone exchange, and regulation of chromatin assembly\u2014suggesting the cluster's core function is chromatin packaging and regulation. Other terms related to neuronal development or viral processes appear less central and may reflect pleiotropy or annotation noise.","confidence":"Medium","size":17,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":1},{"id":"GO:0043486","count":1},{"id":"GO:0010847","count":1},{"id":"GO:0098908","count":1},{"id":"GO:2000627","count":1}]},{"hash":"1128165848486008806","title":"Chitin-based cuticle development and calcium transport","description":"The top GO terms point to chitin-based cuticle development and body morphogenesis, suggesting exoskeleton formation. The calcium-related terms (calcium ion transport and regulation of store-operated calcium entry) imply calcium signaling/transport involvement during this process. Together, these themes indicate cuticle formation coupled with calcium regulation, justifying this label.","confidence":"Medium","size":17,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010171","count":2},{"id":"GO:0040003","count":2},{"id":"GO:2001256","count":1},{"id":"GO:0006816","count":1}]},{"hash":"359932530173457162","title":"Unknown","description":"The top terms are diverse (nervous system development, face morphogenesis, splicing regulation, sensory perception of sound, metabolism, inflammatory mediator production, chemokine regulation, T cell tolerance, etc.) and there is no unifying process; with no edges among proteins, this cluster lacks a cohesive functional theme. Hence Unknown.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0060325","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0007605","count":1},{"id":"GO:0005975","count":1}]},{"hash":"86864438021369972","title":"Larval chitin-based cuticle development","description":"The dominant GO term, larval chitin-based cuticle development (GO:0008363), appears in 14 of the 17 proteins, indicating a strong shared function in larval cuticle formation. The remaining terms are scattered and less represented, suggesting some annotation noise or secondary roles, but the core theme is clear.","confidence":"High","size":17,"edges":124,"triangles":518,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":14},{"id":"GO:0050832","count":1},{"id":"GO:0007596","count":1},{"id":"GO:1900738","count":1},{"id":"GO:0009791","count":1}]},{"hash":"1176623422491655808","title":"Potassium Transport and Membrane Potential Regulation","description":"The set is dominated by GO terms related to potassium ion transmembrane transport and the maintenance/modulation of membrane potential, including resting potential regulation, hyperpolarization, and repolarization (e.g., atrial cardiac muscle action potential repolarization) as well as intracellular potassium homeostasis. While a few terms touch on sensory stimuli like pain, touch, and temperature, the strongest signal is potassium handling and membrane excitability, suggesting a cluster of potassium transporters/channels and regulators.","confidence":"High","size":17,"edges":15,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":6},{"id":"GO:0019233","count":5},{"id":"GO:0060081","count":5},{"id":"GO:0060075","count":4},{"id":"GO:0030322","count":4}]},{"hash":"1372972768757659713","title":"Unknown","description":"The top GO terms are highly diverse, including signaling (Wnt and PDGF), translation initiation, neuronal spine maintenance, IP3 biosynthesis, podosome assembly, and morphogenesis, with little overlap and only a few terms represented. This suggests there is no cohesive, single function linking the proteins, so a generic Unknown label is most appropriate.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":2},{"id":"GO:0060368","count":1},{"id":"GO:1903679","count":1},{"id":"GO:1902951","count":1},{"id":"GO:0032959","count":1}]},{"hash":"1632736161079174981","title":"Organelle fission and fusion regulators","description":"GO terms converge on mitochondrial and peroxisomal fission/fusion, membrane organization, and related vesicle trafficking, with dynamin-family involvement. The cluster appears to group proteins that regulate organelle division and membrane dynamics (mitochondria and peroxisomes), with endocytic recycling linked through shared trafficking mechanisms. Some unrelated terms exist but do not dominate the set.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003374","count":2},{"id":"GO:0007006","count":2},{"id":"GO:0090149","count":2},{"id":"GO:0035904","count":2},{"id":"GO:0016559","count":2}]},{"hash":"245464303084695737","title":"Developmental organogenesis and cell migration regulation","description":"This cluster centers on embryonic development and tissue morphogenesis, with frequent terms for organogenesis, axis elongation, gastrulation, and tissue-specific development (pancreas, prostate) plus programs of transcription regulation and cell migration. The shared theme is regulatory factors coordinating gene expression and cell movement during development, hence a Developmental organogenesis and cell migration regulation label.","confidence":"High","size":17,"edges":19,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0018298","count":2},{"id":"GO:0060029","count":1},{"id":"GO:0060215","count":1},{"id":"GO:0060028","count":1}]},{"hash":"71382350259886495","title":"Unknown","description":"The Top Terms span diverse processes (cell migration, Rho signaling, smooth muscle development, ribosome quality control, insect cuticle development, glial growth, and apoptosis response), with no clear, single functional theme linking them.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006929","count":2},{"id":"GO:0035024","count":2},{"id":"GO:0048745","count":2},{"id":"GO:0018937","count":1},{"id":"GO:1990116","count":1}]},{"hash":"2228324483260263474","title":"Neuronal signaling and locomotion","description":"Top GO terms point to neuronal signaling and ion transport\u2014sodium, potassium, and calcium\u2014along with the ionotropic glutamate receptor pathway, which underpin synaptic transmission and excitability. Behavioral terms such as conditioned taste aversion and social behavior, plus forward locomotion and sensory development (anterior lateral line), further suggest involvement of neural circuits governing movement and perception. Taken together, these terms indicate a cluster centered on neural signaling and locomotor/sensory functions.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001661","count":4},{"id":"GO:0035176","count":3},{"id":"GO:0010157","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0043056","count":3}]},{"hash":"1511393194510606903","title":"Brain GPCR signaling and morphine response","description":"Top terms point to brain-specific signaling, including morphine response and development of striatal/thalamic regions, with regulation of GPCR signaling suggesting opioid-receptor\u2013mediated pathways. Some annotations appear noisy (e.g., plant cytokinin signaling), but the core theme is brain GPCR signaling linked to morphine responsiveness.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0043278","count":5},{"id":"GO:0021756","count":5},{"id":"GO:0021794","count":4},{"id":"GO:2000324","count":4},{"id":"GO:0070979","count":4}]},{"hash":"2023493630142296491","title":"Reproductive and craniofacial skeletal development","description":"The cluster's top GO terms cluster around developmental processes involving reproduction ( GnRH response, ovarian follicle development, copulation) and craniofacial/skeletal formation (muscle cell development, skeletal system, roof of mouth development). Regulatory terms also appear, indicating coordinated developmental regulation. This combination suggests proteins linked to development across reproductive and skeletal/craniofacial domains, justifying the label.","confidence":"Medium","size":17,"edges":44,"triangles":9,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0097211","count":3},{"id":"GO:2000354","count":3},{"id":"GO:0048747","count":3},{"id":"GO:0060021","count":3},{"id":"GO:0001501","count":3}]},{"hash":"1959588657909254029","title":"Oxidative Stress Response and Redox Homeostasis","description":"The top GO terms cluster around redox biology: oxidation-reduction processes, removal of superoxide radicals, and an associated aerobic respiration context, with a selenium ion response suggesting oxidative defense. Some entries (aging-related and pigment/vasodilation signals) are obsolete or less directly connected, so the core theme is redox balance and ROS detoxification rather than a single specific pathway.","confidence":"Medium","size":17,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0051289","count":2},{"id":"GO:0009060","count":2},{"id":"GO:0071291","count":2},{"id":"GO:0003069","count":2}]},{"hash":"2170432581894621482","title":"Notch-regulated development and segmentation","description":"This cluster is dominated by GO terms involving Notch signaling and developmental patterning, including positive regulation of Notch signaling, compartment pattern specification, imaginal disc-derived leg segmentation, and hypochord development, pointing to a shared role in Notch-mediated patterning during development. Some terms (e.g., certain lineage-specific differentiation terms) may reflect cross-species annotations or noise, but the core theme links Notch signaling with segmentation/pattern formation.","confidence":"Medium","size":17,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055016","count":5},{"id":"GO:0016267","count":5},{"id":"GO:0007386","count":5},{"id":"GO:0007143","count":5},{"id":"GO:0045747","count":5}]},{"hash":"838440096366761496","title":"Zinc Ion Homeostasis and Transport","description":"This cluster is dominated by GO terms tied to zinc handling\u2014zinc import across the plasma membrane, intracellular zinc ion homeostasis, detoxification of zinc ion, and response to zinc ion starvation\u2014as well as a related cadmium ion transport term, indicating a shared function in zinc/metal ion uptake and regulation. Some terms (like limb development and glucuronoxylan biosynthesis) appear incidental rather than central to this theme. ","confidence":"High","size":17,"edges":14,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006882","count":2},{"id":"GO:1903615","count":2},{"id":"GO:0044749","count":2},{"id":"GO:0070574","count":2},{"id":"GO:0006831","count":2}]},{"hash":"170093466547587726","title":"Neural development and brain formation","description":"This cluster's top GO terms cluster around neural development: neural tube closure, forebrain development, and brain development are prominent. Additional terms (mitotic cell cycle, DNA-templated transcription) reflect general developmental processes accompanying neural formation, while proteostasis-related terms (ERAD pathway, proteasome assembly, ER stress\u2013induced apoptosis) may reflect quality control during development. Taken together, the proteins are best characterized as involved in neural development and brain formation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0006351","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0007275","count":4},{"id":"GO:0001843","count":4}]},{"hash":"1051746811518663358","title":"Dopamine/Adrenergic GPCR Signaling","description":"The top GO terms cluster around GPCR signaling driven by dopamine and adrenergic receptors, activating phospholipase C and adenylate cyclase to regulate cAMP and GTPase activity, with downstream effects on muscle relaxation and vascular permeability, and heart development. Phototransduction also appears, which falls under GPCR-based sensory signaling, supporting a cohesive GPCR-cAMP/PLC signaling theme.","confidence":"High","size":17,"edges":124,"triangles":520,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060158","count":15},{"id":"GO:0010513","count":15},{"id":"GO:0043950","count":15},{"id":"GO:0043547","count":15},{"id":"GO:0071880","count":15}]},{"hash":"20059215215468045","title":"Protein acetylation and chromatin modification","description":"Most terms cluster around acetylation (peptidyl-lysine N6-acetylation, histone H4 acetylation, N-terminal serine/other acetylations, spermidine/spermine acetylation) and chromatin-related processes (mitotic sister chromatid cohesion, centromeric). Additional terms refer to metabolic pathways that can intersect with acetyl-CoA\u2013dependent reactions (glucosamine, mycothiol biosynthesis) or broader annotations; together these point to a function group centered on acetylation and chromatin regulation rather than a single linear pathway. ","confidence":"High","size":17,"edges":92,"triangles":232,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":13},{"id":"GO:0032918","count":12},{"id":"GO:0046208","count":12},{"id":"GO:0010125","count":12},{"id":"GO:0018003","count":12}]},{"hash":"1039699845260139930","title":"Unknown","description":"Top GO terms span markedly different processes\u2014from cardiac electrophysiology and GPCR signaling to telomere maintenance, epithelial polarity, proteasome assembly, cold response, chemokine production, and Wnt signaling\u2014without a single cohesive function tying the proteins together. Therefore, no specific cluster label other than Unknown is warranted.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0098907","count":5},{"id":"GO:0007205","count":5},{"id":"GO:1904357","count":4},{"id":"GO:0090162","count":4},{"id":"GO:0070682","count":4}]},{"hash":"562673046320954367","title":"Unknown","description":"The GO terms span ion transport, telomere maintenance, epithelial polarity, proteasome assembly, cold response, chemokine production, Wnt signaling, heart electrical activity, and macrophage foam cell differentiation. This broad, disparate mix lacks a clear, shared function or pathway tying the proteins together, suggesting the cluster is heterogeneous rather than functionally cohesive.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071436","count":2},{"id":"GO:1904357","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0070682","count":2},{"id":"GO:0009409","count":2}]},{"hash":"1111166541711249136","title":"Unknown","description":"The top GO terms are varied: body morphogenesis and chitin-based cuticle development alongside carbohydrate metabolism, inflammatory mediator production, chitin catabolic process, epithelial polarity, proteasome assembly, and response to cold. This mix suggests no single, core function that unites the cluster. Therefore a generic Unknown label with None confidence is appropriate.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010171","count":2},{"id":"GO:0040003","count":2},{"id":"GO:0005975","count":1},{"id":"GO:0002532","count":1},{"id":"GO:0006032","count":1}]},{"hash":"1472503660437833178","title":"Glutamatergic synaptic transmission and ion transport","description":"The cluster is dominated by GO terms for ion transmembrane transport (sodium, potassium, glucose) and glutamatergic synaptic functions, including synaptic transmission, plasticity regulation, and receptor clustering. This points to proteins involved in neuronal signaling at glutamatergic synapses and associated ion channel activity, making the label both specific and representative.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:1904659","count":3},{"id":"GO:0048172","count":3},{"id":"GO:0035249","count":3}]},{"hash":"1492912387528605214","title":"Renal Development and Filtration","description":"Top GO terms point to kidney-related biology, with kidney development (GO:0001822) and glomerular filtration (GO:0003094) appearing in the cluster, supporting a renal theme. However, several other terms (e.g., colon epithelial cell migration, innervation, lipoteichoic acid biosynthesis) introduce heterogeneity, making the renal signal only partial. This yields a moderate level of confidence that the cluster reflects kidney-related functions rather than a single cohesive process across all terms.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001558","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0061580","count":1},{"id":"GO:0003094","count":1},{"id":"GO:0014846","count":1}]},{"hash":"2217235790142005025","title":"Sphingolipid transport and metabolism","description":"Based on the top GO terms, the cluster centers on lipid handling, especially sphingolipids: ceramide transport, glycosphingolipid metabolic processes, and glycolipid transport, with several terms pointing to ceramide and glycolipid trafficking. While a few terms touch on signaling or developmental processes (flagellated sperm motility, left-right symmetry, androgen receptor signaling), these appear less central. Overall, the motif is sphingolipid transport and metabolism.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030317","count":2},{"id":"GO:0007368","count":2},{"id":"GO:0030521","count":2},{"id":"GO:2000171","count":2},{"id":"GO:1902389","count":1}]},{"hash":"53887621496855442","title":"Cell signaling and cell cycle regulation","description":"The top GO terms point to signaling pathways (ephrin signaling, receptor localization affecting synaptic plasticity, calcium influx as a signaling mediator) and direct control of cell proliferation and the cell cycle. Although some terms are less coherent (chloroplast targeting, obsolete virus-related terms), the strongest, recurring theme is cellular communication tied to growth/proliferation control.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":3},{"id":"GO:0010745","count":3},{"id":"GO:1900383","count":3},{"id":"GO:0098703","count":3},{"id":"GO:1901187","count":3}]},{"hash":"2297954169979967076","title":"Unknown","description":"The top GO terms are diverse, spanning immune signaling (dendritic cell differentiation, B cell receptor signaling), endocrine/pancreatic processes (pancreas development, insulin secretion in response to glucose), neural development (neuron migration, ventricular zone neuroblast division), as well as ion channel clustering, sarcomere organization, and GI epithelium maintenance. With no edges or triangles, there is no single cohesive function linking these proteins, so a specific functional label cannot be assigned.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0031016","count":1},{"id":"GO:0035773","count":1},{"id":"GO:0045163","count":1}]},{"hash":"578731929379786281","title":"Embryonic organ morphogenesis and patterning","description":"Top GO terms cluster around embryonic development, morphogenesis, and tissue differentiation across multiple organs. Cartilage morphogenesis, left-right pattern formation, placental and pancreatic development, and EMT in heart cushion formation point to a shared role in embryogenesis and organogenesis. Receptor-mediated endocytosis and iron import are general cellular processes that appear as ancillary terms rather than defining the cluster.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0060707","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0060806","count":5}]},{"hash":"446006985606634515","title":"Unknown","description":"The top GO terms span diverse areas including behavioral responses (ethanol, social behavior, serotonin), neural signaling (guanylyl cyclase signaling, cGMP biosynthesis), metabolism (L-phenylalanine biosynthesis), and unrelated processes (ectoine transport, cell wall organization, response to chlorate, oocyte maturation). This lack of a single coherent function or pathway suggests no well-defined cluster theme.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048149","count":2},{"id":"GO:0051470","count":1},{"id":"GO:0071555","count":1},{"id":"GO:0007168","count":1},{"id":"GO:0042428","count":1}]},{"hash":"501756260679699132","title":"Ubiquitin-Dependent Degradation and NF-\u03baB Signaling","description":"The cluster is dominated by ubiquitin-related processes: ubiquitin-dependent protein catabolic process, ERAD pathway, autoubiquitination, and K6-linked ubiquitination, along with signaling events such as NF-\u03baB activation and regulation of apoptosis. This points to a core theme around ubiquitin-mediated protein turnover and immune signaling, with a few outliers that touch on related regulatory areas but do not override the central pattern.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0030433","count":9},{"id":"GO:0051865","count":9},{"id":"GO:0085020","count":9},{"id":"GO:0042981","count":8}]},{"hash":"2022068126731948947","title":"Embryonic development and tissue differentiation","description":"This cluster includes GO terms spanning broad developmental and tissue-specific differentiation processes across multiple organs (cartilage, placenta, pancreas, cerebellum), along with patterning and morphogenesis events, indicating a general embryogenesis/organogenesis theme rather than a single pathway.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051684","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0060536","count":2}]},{"hash":"1047581202101547146","title":"Unknown","description":"The GO terms are highly heterogeneous, covering ion channel clustering, sarcomere organization, GI epithelium maintenance, immune activation, and various developmental processes, with no clear shared function tying the proteins together. Therefore, no specific, cohesive label can be assigned.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045163","count":1},{"id":"GO:0045214","count":1},{"id":"GO:0030277","count":1},{"id":"GO:0071663","count":1},{"id":"GO:0021847","count":1}]},{"hash":"1134355187245458115","title":"Unknown","description":"The top terms span immune effector processes (dendritic cell differentiation, granzyme B production, antibody-dependent cellular cytotoxicity, IL-3 production, STAT signaling) and diverse developmental/tissue processes (glomerulus morphogenesis, myelination, olfactory lobe development, endothelial adhesion). With no edges connecting the proteins and no clear shared function, there isn't a cohesive theme to assign a more specific label.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":3},{"id":"GO:0045663","count":2},{"id":"GO:0072102","count":2},{"id":"GO:0090673","count":2},{"id":"GO:0071663","count":2}]},{"hash":"2191470577737939985","title":"Unknown","description":"The top terms are highly diverse, covering metabolism (thiamine biosynthesis, glycolytic fermentation), development (wing disc patterning), chromatin remodeling, various chloride transport processes, and visual perception. With no edges and only scattered one-term associations, there is no clear, shared function linking the proteins. Therefore, Unknown with None confidence. ","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090180","count":1},{"id":"GO:1903212","count":1},{"id":"GO:2001172","count":1},{"id":"GO:0048190","count":1},{"id":"GO:0030308","count":1}]},{"hash":"1098995927908251780","title":"Unknown","description":"The GO terms across the 17 proteins are highly diverse: chitin biosynthetic process, follicle cell adhesion and epithelium polarity hint at insect development, but other terms include infection structure formation, thiamine biosynthesis regulation, glycolytic fermentation to ethanol, and even some obsolete or unrelated terms. There isn't a single dominant function uniting the cluster, so a precise, meaningful label cannot be assigned.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":2},{"id":"GO:0090180","count":2},{"id":"GO:1903212","count":2},{"id":"GO:2001172","count":2},{"id":"GO:0007299","count":1}]},{"hash":"1098135572019661946","title":"Tissue remodeling and organogenesis","description":"The terms coalesce around extracellular matrix turnover (collagen catabolic process) and skeletal/structural development (intramembranous ossification), alongside organogenesis signals (lung branching morphogenesis, decidualization). Hormonal and peptide regulation (thyroid hormone response, bradykinin catabolic process) further support a theme of developmental tissue remodeling and morphogenesis rather than a single pathway.","confidence":"Medium","size":16,"edges":102,"triangles":387,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0030574","count":16},{"id":"GO:0060448","count":16},{"id":"GO:0097067","count":16},{"id":"GO:0046697","count":16},{"id":"GO:0035593","count":16}]},{"hash":"603160930329226175","title":"Mitochondrial Transport and Metabolism","description":"The GO terms converge on transport activities across the mitochondrial membrane for nucleotides, amino acids, phosphate, and co-factors, plus metabolic processes such as the malate-aspartate shuttle and regulation of membrane potential, and even mitochondrial fission. This pattern suggests a cluster of proteins involved in mitochondrial transport and energy/metabolic regulation, possibly active under amino acid stress.","confidence":"High","size":16,"edges":21,"triangles":2,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0000002","count":9},{"id":"GO:0000066","count":8},{"id":"GO:0034198","count":8},{"id":"GO:0051881","count":8},{"id":"GO:0035435","count":8}]},{"hash":"706451835443939159","title":"Cytoskeleton and organelle dynamics","description":"The top GO terms indicate microtubule-associated protein localization, regulation of cell shape, meiosis spindle movement, and mitochondrial fission regulation, all pointing to cytoskeletal organization and dynamic organelle remodeling. While there are some developmental and signaling terms (cuticle development, female gamete generation, histamine response), the common theme is how the cytoskeleton and organelle dynamics drive cellular remodeling during division and development. Therefore the label emphasizes cytoskeletal and organelle dynamics.","confidence":"Medium","size":16,"edges":14,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035372","count":4},{"id":"GO:0016558","count":3},{"id":"GO:0090403","count":3},{"id":"GO:0008363","count":2},{"id":"GO:0035023","count":2}]},{"hash":"1973026576827176830","title":"Autophagy and Lysosome Trafficking","description":"The cluster centers on ribophagy, calcium-regulated lysosome exocytosis, and regulation of phagocytosis, together with GTPase activity regulation, which all point to vesicle trafficking and autophagic/delivery pathways. IP3 biosynthesis and calcium signaling underpin calcium-dependent membrane fusion, supporting lysosome exocytosis, while terms like myoblast fusion highlight membrane fusion events. Overall, the proteins appear tied to autophagy-lysosome dynamics and related trafficking processes, with some broader fusion-related functions. ","confidence":"Medium","size":16,"edges":10,"triangles":1,"max_degree":6,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0001302","count":4},{"id":"GO:0043087","count":4},{"id":"GO:0032959","count":3},{"id":"GO:1901002","count":3},{"id":"GO:0050764","count":3}]},{"hash":"1413993489320594553","title":"Salivary gland morphogenesis and epithelial differentiation","description":"The top GO terms include salivary gland cavitation and branching involved in salivary gland morphogenesis, suggesting a developmental focus on the gland. Additional terms point to epithelial differentiation (keratinization, cell envelope organization) and epithelial cell physiology (ion transport and calcium regulation), which together imply proteins involved in salivary gland development and epithelial function. Some terms are obscure or obsolete, but the core theme centers on gland morphogenesis and epithelial traits.","confidence":"Medium","size":16,"edges":37,"triangles":5,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0043163","count":1},{"id":"GO:0031424","count":1},{"id":"GO:0043277","count":1},{"id":"GO:0006058","count":1}]},{"hash":"831894197944338341","title":"Larval chitin-based cuticle formation and turnover","description":"The top terms are dominated by larval chitin-based cuticle development and chitin catabolic process, pointing to a cohesive theme of chitin metabolism and exoskeleton formation in larvae. Other terms (glucose response, carbohydrate metabolism, inflammatory mediator production, chemokine regulation) are peripheral and may reflect broader physiological roles, but the strongest signal centers on cuticle synthesis/remodeling and chitin turnover. This cluster most likely groups proteins involved in larval cuticle formation and chitin remodeling.","confidence":"High","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":13},{"id":"GO:0009749","count":1},{"id":"GO:0002023","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0002532","count":1}]},{"hash":"1285419986181712257","title":"Unknown","description":"The top GO terms are highly diverse, including viral entry/replication processes, leukocyte migration, a plant-specific sepal formation term, and RNA-templated DNA biosynthesis, which do not converge on a single coherent function or pathway for the protein set. This lack of a unifying theme makes it inappropriate to assign a precise, representative label.","confidence":"","size":16,"edges":57,"triangles":78,"max_degree":14,"top_function":"protein folding","top_go_terms":[{"id":"GO:1901407","count":6},{"id":"GO:0019061","count":4},{"id":"GO:0019064","count":4},{"id":"GO:0050900","count":4},{"id":"GO:0075713","count":4}]},{"hash":"1191278730223045094","title":"Biosynthesis and Central Metabolism","description":"The cluster shows a strong emphasis on biosynthetic processes (antibiotic biosynthesis, clavulanic acid biosynthesis, protoporphyrinogen IX biosynthesis, carnitine biosynthesis) alongside central metabolic activities (2-oxoglutarate metabolism, TCA cycle) and a related catabolic note (xanthine catabolism). This suggests proteins involved in multiple biosynthetic pathways and core metabolism rather than a single specific function, so a label that combines biosynthesis with central metabolism is appropriate.","confidence":"Medium","size":16,"edges":102,"triangles":343,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0017000","count":5},{"id":"GO:0006151","count":4},{"id":"GO:0046300","count":4},{"id":"GO:0045329","count":4}]},{"hash":"568059059034183383","title":"Immune Cell Recruitment and Inflammatory Signaling","description":"The top GO terms point to leukocyte movement and inflammatory signaling, with positive regulation of TNF production, monocyte chemotaxis, and T cell migration as prominent features, plus foam cell differentiation linked to macrophage activity. Angiogenesis and survival-related terms further fit inflammatory tissue contexts. Although a few terms are more general or unrelated (e.g., spermatid differentiation), the dominant theme is immune cell recruitment and inflammatory signaling, justifying this label.","confidence":"Medium","size":16,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:2001237","count":2},{"id":"GO:0000122","count":2},{"id":"GO:1903672","count":2},{"id":"GO:0007289","count":2},{"id":"GO:0032760","count":1}]},{"hash":"568443083616172860","title":"Larval cuticle development","description":"The cluster is dominated by GO:0008363 (larval chitin-based cuticle development) with 8 proteins, pointing to a shared role in larval cuticle formation. While other terms suggest additional developmental processes (muscle, skeletal system, roof of the mouth, ovarian follicle development) and a minor immune-related term, the strongest, most frequent signal is cuticle-related development, supporting a label centered on larval cuticle formation.","confidence":"Medium","size":16,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":8},{"id":"GO:0097211","count":1},{"id":"GO:2000354","count":1},{"id":"GO:0048747","count":1},{"id":"GO:0060021","count":1}]},{"hash":"1476769058069815979","title":"Transcription and Translation Regulation Core","description":"This cluster is enriched for terms spanning both transcription and translation, including cytoplasmic translation, maturation of SSU rRNA, formation of the translation preinitiation complex, regulation of translational initiation, 7-methylguanosine mRNA capping, and RNA Pol II transcription elongation and its positive regulation. Together, these terms point to a group of proteins involved in core gene expression machinery. Some related terms (nitric oxide response and blood vessel development) appear less directly connected and may reflect broader regulatory roles or annotation breadth.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0006446","count":2},{"id":"GO:0006370","count":2}]},{"hash":"2051208030812030650","title":"Chitin-based cuticle development and remodeling","description":"The strongest GO terms point to larval chitin-based cuticle development and chitin catabolic process, indicating a primary role in cuticle formation and remodeling in larvae. The presence of carbohydrate metabolic process supports a metabolic context for these activities. Immune-related terms (inflammatory mediator production, C-type lectin receptor signaling) appear but are less central, suggesting some overlap with innate immune components rather than defining the core function. Thus, the cluster is best labeled for chitin/cuticle biology with supporting metabolism.","confidence":"Medium","size":16,"edges":84,"triangles":238,"max_degree":14,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0008363","count":10},{"id":"GO:0005975","count":3},{"id":"GO:0002532","count":3},{"id":"GO:0006032","count":3},{"id":"GO:0090197","count":3}]},{"hash":"164492053309902717","title":"Fish neurosensory signaling and locomotion","description":"These proteins cluster around neural signaling and movement in fish, with enrichment for ion transport (K+ and Na+ channels) that underpins neuronal excitability, behavioral processes (startle response, forward locomotion, social behavior), serotonin metabolism, and the anterior lateral line development, underscoring a coherent theme of neurosensory function and locomotion in a fish sensory system.","confidence":"High","size":16,"edges":31,"triangles":18,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0001964","count":4},{"id":"GO:0048025","count":3},{"id":"GO:0042428","count":3},{"id":"GO:0035176","count":3}]},{"hash":"1572451099697107666","title":"Protein Translation and Elongation","description":"The cluster\u2019s GO terms are dominated by translation-related processes (translation, translational elongation, and fidelity), suggesting a core role in protein synthesis. The other terms present appear sporadic and less cohesive, but the translation/elongation theme is the strongest signal.","confidence":"Medium","size":16,"edges":16,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:1990145","count":1},{"id":"GO:0032232","count":1},{"id":"GO:0006414","count":1},{"id":"GO:0071479","count":1}]},{"hash":"1771581801840099733","title":"ncRNA-mediated silencing and translational control","description":"The top GO terms center on miRNA-mediated gene silencing by inhibiting translation, translation initiation and reinitiation, ncRNA-mediated regulatory silencing, and mRNA export/modification, suggesting a cohesive cluster of proteins involved in RNA processing and translation regulation via non-coding RNAs.","confidence":"High","size":16,"edges":21,"triangles":9,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0035278","count":6},{"id":"GO:0001731","count":5},{"id":"GO:0006406","count":5},{"id":"GO:0002188","count":5},{"id":"GO:0075525","count":4}]},{"hash":"223452636171573227","title":"Cerebellar Glutamatergic Synaptic Transmission","description":"This cluster is dominated by GO terms pointing to cerebellar function and glutamatergic synapses, including cerebellar granule cell differentiation, excitatory postsynaptic potentials, and long-term synaptic depression, along with visual learning and synaptic transmission. These together suggest a core theme of cerebellar glutamatergic signaling and plasticity underlying learning and sensorimotor processing, with additional links to behavior and drug responses that reflect broader neural circuitry involvement.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":7},{"id":"GO:0060079","count":6},{"id":"GO:0035249","count":6},{"id":"GO:0021707","count":5},{"id":"GO:0060292","count":5}]},{"hash":"1951104067548519479","title":"Unknown","description":"The terms span stress/physiological responses (fungicide response, startle response, excitatory postsynaptic potential), heart development, viral translation-related activity, and RNA biology (mRNA modification, regulatory ncRNA-mediated gene silencing). There is no single cohesive function dominating the cluster, and several terms are obsolete, making a specific, reliable label unclear. Confidence: None","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060992","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0001964","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0075525","count":2}]},{"hash":"1234187827338876866","title":"Unknown","description":"The top GO terms are highly diverse, including insect development (larval cuticle), ion transport (Na+/K+), sensory learning (olfactory), immune and metabolic signaling (leptin, IL-6), angiogenesis, and even viral translation processes, plus a couple of obsolete terms. This spread suggests there isn\u2019t a single cohesive function or pathway tying these proteins together, so a specific, representative label is not apparent.","confidence":"","size":16,"edges":72,"triangles":143,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0008355","count":2},{"id":"GO:0044320","count":2}]},{"hash":"893477726316757932","title":"Meiosis-associated Actin Remodeling and Muscle Assembly","description":"The cluster is enriched for actin cytoskeleton\u2013related processes, including actin filament network formation, contractile ring/actomyosin assembly, and polar body extrusion, plus meiotic chromosome movement, pointing to regulated actin remodeling during meiosis. Cardiac myofibril assembly indicates a broader theme of actin- and myosin-based organization shared with muscle, suggesting the proteins cofunction in meiosis-related cytoskeletal dynamics and muscle-related assembly.","confidence":"High","size":16,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008360","count":2},{"id":"GO:0055003","count":2},{"id":"GO:0007292","count":1},{"id":"GO:0051758","count":1},{"id":"GO:0071420","count":1}]},{"hash":"1946526570317029271","title":"Chitin-based cuticle development","description":"Most prominent annotations are GO:0040003 chitin-based cuticle development and GO:0010171 body morphogenesis, indicating a role in insect/exoskeleton formation. The other terms are sparse or obsolete and do not point to a different dominant function, so the core theme is cuticle development.","confidence":"High","size":16,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010171","count":5},{"id":"GO:0040003","count":5},{"id":"GO:0075525","count":1},{"id":"GO:1901407","count":1},{"id":"GO:0006378","count":1}]},{"hash":"669109678457593369","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0050832","count":2},{"id":"GO:0050909","count":1},{"id":"GO:0000480","count":1}]},{"hash":"1812838551639038762","title":"Glycolysis and TCA Cycle","description":"This cluster shows strong enrichment for core energy metabolism terms (glycolytic process, TCA cycle, glyceraldehyde-3-phosphate biosynthesis) with supporting links to thiamine biosynthesis and related carbohydrate pathways, suggesting a group of proteins involved in central carbon metabolism. A few terms appear unrelated or obsolete, likely noise.","confidence":"High","size":16,"edges":65,"triangles":153,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":5},{"id":"GO:0009228","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006096","count":3},{"id":"GO:0019878","count":3}]},{"hash":"1246925533367310757","title":"Synaptic development and plasticity","description":"The cluster is enriched for neural-related terms such as axonal fasciculation, positive regulation of synapse assembly, and long-term synaptic depression, pointing to roles in neuronal connectivity and synaptic regulation. While other terms (e.g., apoptotic process, tissue-specific processes) appear, the dominant theme centers on synapse formation and plasticity. This supports a neuronal development/plasticity interpretation, though some outliers temper confidence.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0051497","count":2}]},{"hash":"821585402176227849","title":"Neural sensing and learning via ion channels","description":"The cluster centers on neural sensing and learning across modalities (visual and olfactory learning), social behavior, and locomotion, with strong representation of ion transport and ionotropic glutamate receptor signaling terms. The inclusion of anterior lateral line development further supports a neurosensory/fish sensory context, tying together ion-channel signaling and neural function.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":12},{"id":"GO:0035176","count":11},{"id":"GO:0035725","count":11},{"id":"GO:0043056","count":11},{"id":"GO:0048899","count":11}]},{"hash":"1813236282869730866","title":"Proteostasis and mitophagy","description":"The cluster centers on protein quality control and degradation pathways (cellular response to misfolded protein, ribophagy, proteasome regulatory particle assembly, ubiquitin-independent degradation via multivesicular bodies) together with mitochondrial maintenance processes (regulation of oxidative phosphorylation, mitochondrial transport, mtDNA replication) and related endosome/vacuole trafficking. Although a chitin-based cuticle term appears, the dominant signals point to coordinated proteostasis and mitochondrial quality control through both ubiquitin-dependent and autophagic routes.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0072671","count":1},{"id":"GO:0070682","count":1},{"id":"GO:1903862","count":1},{"id":"GO:0071218","count":1}]},{"hash":"805367940953993774","title":"Broad-spectrum membrane transporters","description":"The top terms indicate a strong enrichment for various transmembrane transport activities across multiple substrates (organic acids, sugars, xenobiotics, ions) and a related osmotic stress response. This points to a cluster of transporter proteins with broad substrate specificity rather than a single, narrowly defined pathway, hence the label Broad-spectrum membrane transporters.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":1},{"id":"GO:1905431","count":1},{"id":"GO:0019852","count":1},{"id":"GO:0042908","count":1},{"id":"GO:0070837","count":1}]},{"hash":"221200765594508887","title":"Unknown","description":"The top terms mix neural signaling/synaptic terms (social behavior, long-term synaptic depression, receptor clustering) with DNA repair terms (base-excision repair, nucleotide-excision repair, DNA damage recognition). With no edges connecting proteins, there isn\u2019t a single cohesive function tying the cluster together, so a robust, specific label cannot be assigned.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0043113","count":2},{"id":"GO:0008630","count":1},{"id":"GO:0009636","count":1}]},{"hash":"2291395662107370832","title":"Unknown","description":"The top terms show a mix of translation-related processes, several distinct metabolic pathways, redox/oxidation ideas, and even developmental terms, with no single cohesive function tying them together. This heterogeneity makes it hard to assign a specific, representative label beyond Unknown.","confidence":"","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0009442","count":2},{"id":"GO:0019295","count":2},{"id":"GO:0006144","count":2},{"id":"GO:0055114","count":2}]},{"hash":"2002899719161236792","title":"RNA processing and translation regulation","description":"This cluster shows strong signals for RNA processing (splicing regulation, mRNA modification, polyadenylation) and translational control (preinitiation complex formation, initiation regulation), with additional ncRNA-mediated gene silencing. Together these terms suggest a theme of RNA metabolism and coordinated control of gene expression at transcriptional and translational levels. Some terms are obsolete, but the overall pattern remains coherent.","confidence":"Medium","size":16,"edges":25,"triangles":38,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0075525","count":6},{"id":"GO:1901407","count":6},{"id":"GO:0006378","count":6}]},{"hash":"89195904517176642","title":"Mitochondrial lipid metabolism and ER Ca2+ regulation","description":"The cluster is enriched for mitochondrial-associated lipid pathways: ubiquinone biosynthesis, tocopherol cyclase activity, and overall lipid homeostasis, together with ER calcium homeostasis and related regulation of calcium transport and ER-stress\u2013related apoptotic signaling. These themes point to a cohesive function centered on mitochondrial lipid metabolism and ER calcium signaling, with some brain-development annotations likely reflecting tissue-specific context. ","confidence":"High","size":16,"edges":116,"triangles":506,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:1902171","count":3},{"id":"GO:0055088","count":3},{"id":"GO:0021692","count":3},{"id":"GO:0010795","count":3},{"id":"GO:1901006","count":3}]},{"hash":"1098923245547844287","title":"Developmental Processes and Cell Division","description":"The terms point to both development (face morphogenesis, spermatogenesis, larval lymph gland hemopoiesis) and cell proliferation (mitotic cell cycle, spindle assembly checkpoint, cell division). This suggests a broad developmental/proliferative role rather than a single pathway, so the label is representative but not strongly specific. ","confidence":"Medium","size":16,"edges":20,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0035167","count":1},{"id":"GO:0000278","count":1},{"id":"GO:0090266","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0060325","count":1}]},{"hash":"1716791953618806126","title":"Unknown","description":"The Top Terms are highly diverse (mRNA processing, ribosomal RNA methylation, cell growth, spindle assembly, virus and cocaine responses, nodulation, etc.), with no single dominant function linking all proteins. Because the cluster spans multiple unrelated processes, a coherent, specific label is not supported.","confidence":"","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0007611","count":2},{"id":"GO:0051225","count":2},{"id":"GO:0009615","count":2}]},{"hash":"609372463121386650","title":"Neuronal signaling and innervation","description":"The top GO terms point to diverse neural communication processes: GABA signaling, acetylcholine and histamine responses, sensory processing, and innervation, along with action potential regulation and amino acid/metal ion responses. This pattern suggests a cluster of proteins central to synaptic transmission and neural innervation across multiple neurotransmitter systems. ","confidence":"High","size":16,"edges":98,"triangles":317,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0045759","count":13},{"id":"GO:0042220","count":13},{"id":"GO:0050893","count":13},{"id":"GO:0071294","count":13},{"id":"GO:0007214","count":13}]},{"hash":"1760758260351935871","title":"Unknown","description":"The GO terms here cover a wide range of unrelated areas (nematode pharyngeal activity, reproductive interactions, muscle development, embryonic axis formation, proteolysis, polyspermy prevention, molting/cuticle biology). With no edges or coherent shared function across terms, there isn\u2019t a clear common theme to label this cluster; thus, Unknown with None confidence.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043050","count":2},{"id":"GO:2000360","count":2},{"id":"GO:0048632","count":2},{"id":"GO:0035124","count":2},{"id":"GO:0006508","count":2}]},{"hash":"1928768011581707278","title":"Placental development and embryonic morphogenesis","description":"The GO terms show placental/trophoblast-related development (trophoblast giant cell differentiation, embryonic placenta development, negative regulation of this process) alongside broader embryonic morphogenesis signals (left-right patterning, cartilage morphogenesis, endocrine system development). While immune terms appear, the dominant pattern centers on placenta and embryonic tissue differentiation. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0060707","count":5}]},{"hash":"628106376044751074","title":"Ubiquitin-Dependent Regulation","description":"This cluster shows a clear emphasis on ubiquitin-related processes: ubiquitin-dependent protein catabolic process, K33-linked ubiquitination, and regulation of protein ubiquitination. While some other terms (muscle development, immune signaling) may be tangential or noisy, the recurring ubiquitination terms strongly support naming it as ubiquitin-dependent regulation of proteins and degradation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":6},{"id":"GO:0032764","count":5},{"id":"GO:0042787","count":5},{"id":"GO:2000312","count":5},{"id":"GO:1904431","count":5}]},{"hash":"86672040066194847","title":"Endomembrane trafficking and exocytosis","description":"These proteins are enriched for vesicle transport along the secretory pathway: ER\u2013Golgi trafficking (COPII budding), endosome to Golgi and recycling routes, and delivery to the plasma membrane, plus exocytosis regulation. The cell-cycle signals are likely incidental noise relative to the dominant trafficking theme.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0032456","count":2},{"id":"GO:0045022","count":2},{"id":"GO:1903078","count":2}]},{"hash":"883825645130817852","title":"Muscle contraction regulation and sarcomere organization","description":"The strongest signals are about skeletal muscle contraction, sarcomere organization, and muscle attachment, with related cytoskeletal adhesion processes (focal adhesion, Rho signaling) and cell spreading. A minority of terms touches immune signaling (IL-2), but overall the cluster appears to group cytoskeletal/adhesion components that regulate muscle structure and function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0014728","count":4},{"id":"GO:0045214","count":3},{"id":"GO:0007155","count":3},{"id":"GO:1900042","count":3},{"id":"GO:0035023","count":3}]},{"hash":"1028555946833486761","title":"DNA Repair and Genome Maintenance","description":"The top GO terms cluster around DNA damage recognition and repair, notably nucleotide-excision repair (including transcription-coupled NER) and mitochondrial DNA repair, with related telomere maintenance regulation. A few terms relate to signaling pathways (e.g., Wnt) or other processes, but the dominant theme is genome maintenance and DNA repair. This label captures the most representative function of the cluster.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":2},{"id":"GO:0000715","count":2},{"id":"GO:0006283","count":2},{"id":"GO:1904357","count":1},{"id":"GO:1904044","count":1}]},{"hash":"1699604250117461405","title":"Actin cytoskeleton remodeling and cell migration","description":"The top GO terms cluster around Rho signaling, assembly of actin-rich structures (microspikes, filopodia), and processes tied to cell movement and morphogenesis (melanocyte migration, myoblast fusion, CNS development). This points to a group of proteins coordinating actin dynamics and migratory signaling rather than a single pathway, making the actin remodeling/migration theme most representative.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0030035","count":3},{"id":"GO:0016197","count":3},{"id":"GO:0046847","count":3},{"id":"GO:0070374","count":2}]},{"hash":"575726353293138451","title":"Neural differentiation and synaptic regulation","description":"The cluster\u2019s top GO terms cluster around neural development and synaptic function: astrocyte and striatal neuron differentiation, long-term potentiation/depression, social behavior, and IGF signaling, with supporting roles for JNK pathway regulation. While some terms are broad (e.g., transcription regulation), the overall pattern points to neuronal differentiation and modulation of synaptic activity.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048711","count":3},{"id":"GO:0035176","count":2},{"id":"GO:1900273","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0046328","count":2}]},{"hash":"568756886508657579","title":"Embryonic development and organ morphogenesis","description":"The cluster is enriched for GO terms tied to embryogenesis, organ formation, and tissue patterning (endocrine system development, left-right patterning, cartilage morphogenesis, placental development, pancreatic cell development, midbrain development), with some transcriptional regulation activity, pointing to a cohesive developmental program.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":8},{"id":"GO:0003198","count":8},{"id":"GO:0060536","count":8},{"id":"GO:0060806","count":8},{"id":"GO:0060972","count":8}]},{"hash":"814425748867272928","title":"Ubiquitin-Dependent Immune Regulation","description":"The cluster centers on ubiquitin-related processes (ubiquitin-dependent protein catabolic process, K33-linked ubiquitination, regulation of protein ubiquitination) and immune cell modulation (mast cell cytokine production, IgE isotype switching, dendritic cell differentiation). Together these suggest a theme of ubiquitin-mediated control of immune signaling and development, despite some noisy/obsolete terms in the mix.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0032764","count":5},{"id":"GO:2000312","count":5},{"id":"GO:1904431","count":5},{"id":"GO:0045497","count":5}]},{"hash":"952160414885301311","title":"Protein Deubiquitination and Trafficking Regulation","description":"The top GO terms cluster around ubiquitin-related processes (deubiquitination, ubiquitin-dependent protein catabolic processes) and control of trafficking (negative regulation of clathrin-dependent endocytosis), with ties to cellular stress responses, mitochondrial fusion, calcium signaling, and neurotransmitter release. This points to a cohesive module balancing protein quality control with membrane trafficking and signaling.","confidence":"Medium","size":15,"edges":104,"triangles":442,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":9},{"id":"GO:1900186","count":5},{"id":"GO:0000753","count":5},{"id":"GO:0097237","count":5},{"id":"GO:1903071","count":5}]},{"hash":"2107408623937517040","title":"Nucleotide and Proteoglycan Biosynthesis","description":"The proteins here map to pyrimidine nucleotide metabolism (dUTP/dUMP/dITP biosynthesis and catabolism) and to glycosaminoglycan/proteoglycan biosynthesis (heparan sulfate, keratan sulfate, and heparin), with related sulfation activity, suggesting a biosynthesis-focused cluster that spans nucleotide metabolism and GAG/proteoglycan assembly.","confidence":"Medium","size":15,"edges":21,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006229","count":1},{"id":"GO:0006226","count":1},{"id":"GO:0035863","count":1},{"id":"GO:0009220","count":1},{"id":"GO:0046081","count":1}]},{"hash":"1052500609712256914","title":"Neural development and synaptic regulation","description":"This cluster is dominated by GO terms tied to neural and sensory development and function, including dendrite development, motor neuron axon guidance, cochlea morphogenesis, and positive regulation of synapse structural plasticity, as well as signaling pathways like calcineurin-NFAT that influence neuronal activity. While a couple of terms touch on muscle or cardiac morphogenesis (sarcomere organization, heart development), the prevailing theme centers on neural/sensory morphogenesis and synaptic regulation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":6},{"id":"GO:0008045","count":6},{"id":"GO:0006470","count":6},{"id":"GO:0090103","count":6},{"id":"GO:0070830","count":6}]},{"hash":"1826836205782980002","title":"Unknown","description":"The GO terms are highly diverse, including embryonic development, innate immunity, auditory perception, antibiotic response, neuronal signaling (EPSP), various transcription and GTPase regulatory processes, apoptosis, and amino acid response. There is no clear, single shared function or pathway linking these proteins, suggesting a miscellaneous cluster rather than a coherent biological module.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0060079","count":3}]},{"hash":"697886175141837847","title":"Forebrain and Olfactory Development","description":"The cluster is dominated by GO terms associated with brain and sensory organ formation, including forebrain development, olfactory pit and nose development, and anterior/posterior pattern specification, along with related retinoid metabolism linked to neural/retinal development and neural neurotransmitter pathways (GABA shunt). This points to a cohesive program governing early neural and olfactory system formation.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":13},{"id":"GO:0042574","count":13},{"id":"GO:0021983","count":7},{"id":"GO:0006540","count":7},{"id":"GO:0043584","count":7}]},{"hash":"1846690478178603630","title":"Neural development and axon guidance signaling","description":"The proteins are enriched for GO terms centered on nervous system development, axon guidance, and synapse organization, with signaling pathways like Smoothened (Hedgehog) and Roundabout (ROBO) and ERK cascade regulation pointing to neuronal connectivity and patterning. Some terms (kidney development, ossification) are less central and may reflect pleiotropic roles, but the dominant theme is neural development and axon guidance.","confidence":"Medium","size":15,"edges":7,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":6},{"id":"GO:0001822","count":6},{"id":"GO:0007224","count":6},{"id":"GO:0035385","count":6},{"id":"GO:0050808","count":5}]},{"hash":"676266282789742087","title":"Sodium and Potassium Ion Transporters","description":"The Top Terms show strong enrichment for sodium and potassium ion transmembrane transport, with ectoine transmembrane transport also present, which points to a core of membrane transporter proteins. Other terms like cell wall organization and neural/behavioral processes appear as secondary annotations, likely noise or multifunctionality, but do not outweigh the transporter signal. Overall, the cluster seems best characterized as ion transporters with some additional, less central functional themes.","confidence":"High","size":15,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0051470","count":2},{"id":"GO:0071555","count":2},{"id":"GO:0042428","count":2}]},{"hash":"1970334857132710718","title":"Larval neural development and locomotion","description":"The top GO terms point to larval development (cuticle and lateral line development) alongside neural function (synaptic plasticity, social behavior) and locomotion (forward movement, ion transport). This combination suggests proteins involved in sensory-neural development and motor activity in larvae, making a label centered on larval neural development and locomotion appropriate.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":6},{"id":"GO:0035176","count":4},{"id":"GO:1900273","count":4},{"id":"GO:0060292","count":4},{"id":"GO:0010157","count":3}]},{"hash":"1568402502320477814","title":"Plant Meiosis and Telomere Maintenance","description":"The top GO terms cluster around meiotic processes (premeiotic DNA replication, male meiosis I), telomere maintenance (via telomerase and via recombination), and chromosomal events such as chiasma assembly, with pollen development pointing to plant reproductive context. Together these terms indicate a coherent theme of meiotic chromosome dynamics and telomere regulation in plants, possibly linking pollen formation to meiosis. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0006279","count":1},{"id":"GO:0007141","count":1},{"id":"GO:0007004","count":1},{"id":"GO:0009555","count":1}]},{"hash":"677433359490374593","title":"Regulated signaling and epithelial morphogenesis","description":"These proteins are linked to regulating signaling pathways (Fc receptor signaling, PDGFR signaling, translation initiation, UPR regulation) and to tissue organization processes (epithelial cell polarity, mammary gland duct branching, developmental patterning). The common thread is regulation of how cells communicate and organize into structured, polarized tissues during development and homeostasis, rather than a single pathway. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060368","count":1},{"id":"GO:1903679","count":1},{"id":"GO:1902951","count":1},{"id":"GO:0032959","count":1},{"id":"GO:0071800","count":1}]},{"hash":"1163684246604550051","title":"Vacuolar Amino Acid Transporters","description":"Most of the prominent GO terms describe transmembrane transport of amino acids into the vacuole (glutamate, serine, histidine, arginine, alanine) and related ions, pointing to a cluster of vacuolar amino acid transporters. The other development-related terms (larval cuticle, root cap, cell wall) seem less connected and may reflect broader membrane-associated roles or annotation noise, but the core signal is vacuolar amino acid transport.","confidence":"Medium","size":15,"edges":47,"triangles":5,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0071555","count":2},{"id":"GO:0048829","count":2},{"id":"GO:0090515","count":2},{"id":"GO:0090516","count":2}]},{"hash":"1640567796042808001","title":"Neuronal synaptic plasticity and actin remodeling","description":"This cluster is dominated by GO terms related to neural function and synaptic plasticity (social behavior; LTP and LTD), supported by receptor clustering and significant actin cytoskeleton remodeling (actin bundle assembly, barbed-end capping, lamellipodium morphogenesis). Trafficking processes (COPII vesicle loading) and growth-factor signaling (PDGF receptor pathway) further tie membrane trafficking and signaling to synaptic changes. A distant term on larval cuticle development is an outlier, but the core signals point to neuronal plasticity and cytoskeletal dynamics.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":4},{"id":"GO:1900273","count":4},{"id":"GO:0060292","count":4},{"id":"GO:0008363","count":3},{"id":"GO:0043113","count":3}]},{"hash":"1310329311622717350","title":"Neural signaling with toxin response","description":"Based on the GO terms, this cluster concentrates on neural development and signaling (optic nerve morphogenesis, GABA signaling, regulation of action potentials, sensory processing), with additional signals of toxin/xenobiotic responsiveness (insecticide, cocaine) and zinc ion response. The innate immune term is less cohesive with the main neural theme, but the overall pattern supports neural signaling plus environmental response. ","confidence":"Medium","size":15,"edges":17,"triangles":2,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:1901214","count":2},{"id":"GO:0021631","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0017085","count":1}]},{"hash":"994245165493872563","title":"Ubiquitin-Proteasome Degradation in Mitosis","description":"The cluster is heavily enriched for ubiquitin-dependent protein catabolic processes (ERAD, SCF, APC/C), including K11- and K48-linked ubiquitination, along with cell division and mitotic cell cycle terms, pointing to ubiquitin-mediated proteolysis governing mitosis. Peroxisome import and related terms are present but secondary to the dominant UPS and cell-cycle signal.","confidence":"High","size":15,"edges":14,"triangles":8,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0030433","count":6},{"id":"GO:0051865","count":5},{"id":"GO:0031146","count":5},{"id":"GO:0070979","count":4}]},{"hash":"398766960921027311","title":"Insect Toll signaling and embryonic development","description":"This cluster\u2019s top GO terms point to innate immunity via the Toll pathway and antimicrobial peptide biosynthesis (antifungal and antibacterial peptides), suggesting Toll-mediated immunity. Additional terms about axis specification, larval cuticle development, and CNS formation imply a developmental/insect context. The Toll/immunity theme is the strongest signal, with development as a secondary context, so the label reflects both aspects. ","confidence":"Medium","size":15,"edges":14,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006967","count":1},{"id":"GO:0031637","count":1},{"id":"GO:0008045","count":1},{"id":"GO:0021556","count":1},{"id":"GO:0008063","count":1}]},{"hash":"2227870556427121273","title":"Embryonic organ morphogenesis and development","description":"Based on the top GO terms, the cluster centers on embryonic development and morphogenesis across multiple organs (pancreas, kidney ureteric bud, neural crest, digestive tract, lens, skeletal muscle, lung/bronchus). The mix of tissue-specific morphogenesis and differentiation terms, along with transcriptional regulation terms, suggests these proteins participate in broad regulatory programs driving organogenesis rather than a single tissue pathway.","confidence":"High","size":15,"edges":46,"triangles":56,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031018","count":9},{"id":"GO:0000122","count":8},{"id":"GO:0090190","count":8},{"id":"GO:0001755","count":8},{"id":"GO:0048557","count":8}]},{"hash":"2248809238410066376","title":"Neural development and myelination","description":"This cluster is dominated by nervous system development terms: otolith morphogenesis, axonal fasciculation, positive regulation of synapse assembly, and myelination, with an additional note on clustering of voltage-gated potassium channels. Although there are some vascular and immune-related terms present, the strongest, most coherent signal relates to neuronal differentiation, connectivity, and maturation.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032474","count":3},{"id":"GO:0007413","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0048661","count":3},{"id":"GO:0045087","count":3}]},{"hash":"2290359857189348806","title":"Developmental signaling and cytoskeletal regulation","description":"This cluster features developmental terms across multiple tissues (heart, nervous system, skeletal) alongside signaling/cytoskeletal processes (Rho-mediated signal transduction and calcium-dependent exocytosis), plus stimulus-response terms, suggesting proteins involved in signaling that guides development and coordinates cellular structure.","confidence":"Medium","size":15,"edges":96,"triangles":349,"max_degree":14,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0007124","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0007266","count":4}]},{"hash":"1923209066161786349","title":"Actin Cytoskeleton Remodeling in Neuronal Migration","description":"The cluster centers on actin cytoskeleton organization and neuronal migration, highlighted by terms like negative regulation of GTPase activity and extension of leading processes in cortical radial glia during migration, pointing to actin-driven motility in brain development. Some metabolic terms appear but do not define the main theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019509","count":3},{"id":"GO:0016310","count":3},{"id":"GO:0009088","count":3},{"id":"GO:0019284","count":3},{"id":"GO:0046677","count":3}]},{"hash":"967683970194607962","title":"Glycan Biosynthesis in Development","description":"The cluster prominently features GO terms tied to glycan biosynthesis and glycosylation (poly-N-acetyllactosamine biosynthetic process, Lewis A epitope biosynthetic process, and O-linked glycosylation via hydroxyproline), plus several developmental processes (follicle development, follicle cell adhesion, root hair development, insect visual primordium formation). This combination suggests a theme where glycosylation modulates development and cell adhesion, making \"Glycan Biosynthesis in Development\" a coherent label, though some terms reflect unrelated stress responses.","confidence":"Medium","size":15,"edges":13,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051402","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0010165","count":3},{"id":"GO:0001541","count":3},{"id":"GO:0001744","count":3}]},{"hash":"584908315239323016","title":"Embryonic neural and craniofacial development","description":"This cluster includes proteins linked to early embryonic morphogenesis across neural, craniofacial, pituitary, limb, and heart structures (forebrain neuron commitment, cerebral cortex regionalization, palate and limb morphogenesis, outflow tract development, skeletal formation) plus general transcriptional regulation, pointing to a set of factors driving embryogenesis and organogenesis with neural/craniofacial emphasis.","confidence":"Medium","size":15,"edges":3,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021902","count":3},{"id":"GO:0060021","count":3},{"id":"GO:0048706","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0023019","count":3}]},{"hash":"2288396619094661475","title":"Developmental signaling and transcription","description":"Proteins here link DNA-templated transcription with multiple signaling pathways governing development and tissue patterning, including JNK cascade, ephrin signaling, Wnt signaling, PDGF response, and planar cell polarity establishment. The mix of multicellular development and skeletal development terms supports a developmental/regulatory theme, though an outlier term like pollen recognition may be incidental. Overall, the cluster centers on developmental signaling and transcriptional regulation.","confidence":"Medium","size":15,"edges":32,"triangles":32,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0001501","count":5},{"id":"GO:0007254","count":5},{"id":"GO:0036120","count":4},{"id":"GO:0048013","count":4}]},{"hash":"925378143088139461","title":"Chromosome cohesion and condensation","description":"This cluster centers on chromosomal architecture during cell division, with strong signals for mitotic sister chromatid cohesion, mitotic chromosome condensation, centromeric cohesion maintenance, and DNA replication, plus meiotic chromosome condensation. While a couple of terms touch broader chromatin organization (tRNA gene clustering, rDNA chromatin condensation), the dominant theme is cohesin/condensin\u2013mediated chromosome cohesion and condensation in mitosis (and meiosis context).","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007064","count":2},{"id":"GO:0007076","count":2},{"id":"GO:1903342","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0071960","count":2}]},{"hash":"1240265145352984728","title":"MAPK/JNK signaling and cell cycle regulation","description":"The top GO terms point to JNK/MAPK pathway activity and its regulation (JNK cascade, inactivation of MAPK activity) along with processes tied to cell growth and division (spindle assembly, cell growth). Other terms involve protein deneddylation regulation and germline development, which can connect to signaling and cell-cycle control in development but are more peripheral. Overall, the cluster seems to be centered on MAPK/JNK signaling regulation with links to cell-cycle/spindle-associated processes, hence the chosen label. Confidence: Medium","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000188","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0051225","count":2},{"id":"GO:0016049","count":2},{"id":"GO:0034260","count":1}]},{"hash":"326820237191983853","title":"Liver and adipose development with energy metabolism","description":"The cluster shows strong representation of liver development and adipose tissue development, along with energy-related processes like response to starvation and ketone body catabolic activity, suggesting a cohesive theme of developmental maturation of metabolic tissues coupled to lipid/energy metabolism.","confidence":"High","size":15,"edges":84,"triangles":265,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0042594","count":5},{"id":"GO:0001889","count":5},{"id":"GO:0014070","count":5},{"id":"GO:0042619","count":4},{"id":"GO:0060612","count":4}]},{"hash":"1216423684127600369","title":"Unknown","description":"The top terms mix developmental signaling (Wnt), transcription regulation, and broad immune/coagulation processes with no clear single theme or interaction, and there are no edges connecting the proteins. This heterogeneity prevents a coherent, specific label beyond Unknown.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":3},{"id":"GO:0015074","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0050832","count":2}]},{"hash":"1405974216369924663","title":"Embryonic Morphogenesis and Tissue Remodeling","description":"This cluster centers on developmental and morphogenetic processes, including foregut morphogenesis, notochord formation, and distal tubule development, along with extraceullar-mmatrix remodeling (collagen fibril organization) and sprouting angiogenesis, suggesting a coherent theme of tissue patterning and remodeling during development. Neurotransmitter secretion indicates secretory potential, while response to estradiol and LPS hints at signaling crosstalk; overall the dominant signal is developmental morphogenesis with remodeling. Confidence: Medium","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007269","count":6},{"id":"GO:0032496","count":5},{"id":"GO:0007568","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0007440","count":4}]},{"hash":"2233295361587569926","title":"ER Protein Quality Control","description":"The top GO terms cluster around the endoplasmic reticulum handling of proteins\u2014retention in the ER lumen, retrograde ER-to-cytosol transport, and ubiquitin-dependent ERAD/ER quality control, plus N-glycan processing to lysosomes. These together point to ER protein folding/quality control and glycoprotein processing in the secretory pathway as the core function of the cluster, with some development terms likely incidental. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048666","count":2},{"id":"GO:0046835","count":1},{"id":"GO:1904153","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0016256","count":1}]},{"hash":"1291290495234647744","title":"Fatty acid oxidation and redox balance","description":"The cluster is dominated by GO terms tied to oxidation-reduction processes, beta-oxidation of fatty acids, and carnitine metabolism, along with cell redox homeostasis. These point to a core function in lipid-derived energy production and redox regulation, with secondary associations to heart development and neural aspects. Thus a name emphasizing fatty acid oxidation and redox balance best captures the shared theme.","confidence":"Medium","size":15,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0007409","count":2},{"id":"GO:0033540","count":2},{"id":"GO:0019254","count":2},{"id":"GO:0045454","count":2}]},{"hash":"2166354660262628927","title":"Actin-driven membrane remodeling and endocytosis","description":"The proteins show enrichment for actin cytoskeleton organization, filopodium assembly, plasma membrane tubulation, membrane invagination, and small GTPase\u2013mediated signaling, all pointing to dynamic cortical remodeling that drives filopodia formation and receptor-mediated endocytosis. The cluster thus reflects coordinated cytoskeletal and membrane trafficking activities at the plasma membrane. The obsolete NF-kappaB term is an outlier and does not change the overall interpretation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0048260","count":2},{"id":"GO:0043314","count":2},{"id":"GO:0060313","count":2},{"id":"GO:0007264","count":2}]},{"hash":"328088987246816218","title":"Ubiquitin-dependent immune regulation","description":"The cluster centers on ubiquitin-related processes (ubiquitin-dependent proteolysis, K33-linked ubiquitination, and regulation of ubiquitination) and immune functions (negative regulation of mast cell cytokine production, dendritic cell differentiation, and IgE isotype switching). Together these terms suggest a group of proteins that coordinate protein turnover via ubiquitin to modulate immune signaling, despite some noise from obsolete or less relevant terms. This coherent theme points to a specific umbrella function rather than unrelated processes.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0032764","count":8},{"id":"GO:2000312","count":8},{"id":"GO:1904431","count":8},{"id":"GO:0045497","count":8}]},{"hash":"1898773104823877533","title":"Neuronal Ion Transport and Synaptic Signaling","description":"The dominant GO terms point to neuronal ion transport (sodium, potassium, calcium), excitatory postsynaptic potential, and neural development (axonogenesis, substantia nigra development). The presence of amphetamine response and long-term memory suggests dopaminergic signaling and learning processes; together these indicate a cluster centered on neuronal excitability and synaptic signaling, with a dopaminergic development angle. A peripheral term like 4-hydroxyphenylacetate transport may reflect broader neuronal metabolite transport but is not central to the core theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0006816","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0001975","count":2}]},{"hash":"279850117115681171","title":"Ubiquitin-Mediated Immune Signaling","description":"The top terms are dominated by ubiquitin-dependent protein catabolic processes and polyubiquitination, with strong links to defense against viruses and innate immune responses, plus involvement of NF-kappaB signaling. A circadian regulation term is present but secondary. This points to a theme of ubiquitin-driven regulation of immune pathways as the cluster\u2019s core function.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0051607","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0042752","count":5},{"id":"GO:0042981","count":4}]},{"hash":"571450966425484439","title":"Neural development and brain regionalization","description":"The top GO terms are dominated by neural development and CNS patterning (neuron migration, cerebral cortex regionalization), plus nervous system regulation of behavior and respiration, suggesting the cluster centers on neural development and CNS function. A few bone-related terms exist but are much less represented, so the neural theme appears primary.","confidence":"Medium","size":14,"edges":23,"triangles":11,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0001764","count":2},{"id":"GO:0002076","count":2},{"id":"GO:0021796","count":2},{"id":"GO:0060133","count":2},{"id":"GO:0007626","count":2}]},{"hash":"1933757515393824973","title":"Unknown","description":"The top GO terms cover immune regulation, protein ubiquitination, and various developmental/physiological processes with little overlap, so there is no single coherent function tying the proteins together. This makes it unclear what specific label best represents the cluster.","confidence":"","size":14,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032764","count":3},{"id":"GO:2000312","count":3},{"id":"GO:0070294","count":3},{"id":"GO:0072156","count":3},{"id":"GO:0007519","count":3}]},{"hash":"1937093587901746355","title":"Golgi- and synaptic vesicle trafficking","description":"This cluster is dominated by GO terms for vesicle transport and exocytosis, including SNARE complex assembly, vesicle targeting, intra-Golgi transport, and Golgi ribbon formation, plus synaptic vesicle exocytosis and related synaptic potentiation. Immune-cell degranulation terms (eosinophil/NK cell) further support regulated exocytosis. Overall, the shared theme is vesicle trafficking and secretion at Golgi and synaptic sites.","confidence":"High","size":14,"edges":22,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0035493","count":3},{"id":"GO:0006903","count":3},{"id":"GO:0006891","count":3},{"id":"GO:0043134","count":3},{"id":"GO:0090161","count":3}]},{"hash":"1400221461371672317","title":"Unknown","description":"Top terms span signaling (cAMP, guanylyl cyclase), neural/sensory functions (sound perception, vocalization), polarity and development (epithelial polarity, planar cell polarity), transport (carnitine), and immune regulation (IL-12, opsonization). This broad mix suggests no single cohesive function or pathway defines the cluster, so a specific label cannot be reliably assigned.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019933","count":8},{"id":"GO:0007605","count":8},{"id":"GO:0045198","count":7},{"id":"GO:0090179","count":7},{"id":"GO:0015879","count":7}]},{"hash":"909744081326892422","title":"Developmental Morphogenesis & Hormone Signaling","description":"The cluster is dominated by GO terms tied to developmental processes across tissues (foregut morphogenesis, ureter development, cardiac muscle proliferation, osteoblast differentiation) and regulation of hormone secretion (LH/FSH). SMAD signaling and transcriptional programs by RNA polymerase II further suggest a cohesive theme of developmental differentiation governed by transcriptional regulation and signaling pathways, rather than a single fixed pathway.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0035470","count":4},{"id":"GO:0048617","count":3},{"id":"GO:0072189","count":3}]},{"hash":"2164777105318976707","title":"Developmental morphogenesis and neural/heart formation","description":"The top GO terms cluster around developmental processes across tissues, including neuron development, mesenchyme development, floor plate development, sinus venosus morphogenesis, and outflow tract morphogenesis, indicating a shared role in embryonic organogenesis and tissue patterning. While a few terms are plant-specific or obsolete, the overall theme is developmental morphogenesis in neural and cardiac contexts, justifying a label focused on development and morphogenesis.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0060766","count":14},{"id":"GO:0045668","count":14},{"id":"GO:0010374","count":13},{"id":"GO:0035481","count":13},{"id":"GO:0042981","count":13}]},{"hash":"572144565832814292","title":"Glutamatergic Synaptic Transmission and Plasticity","description":"The top GO terms emphasize excitatory glutamatergic neurotransmission, including sodium and potassium transmembrane transport, excitatory postsynaptic potentials, and regulation of long-term synaptic plasticity, pointing to a neuronal signaling module. Additional terms such as sensory perception of touch, forward locomotion, and anterior lateral line development suggest a zebrafish mechanosensory-neural context, reinforcing a theme of glutamatergic synapses involved in sensory processing and locomotion.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0050975","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0035249","count":4}]},{"hash":"2220885836337427539","title":"Developmental transcription regulation and chromatin remodeling","description":"The top GO terms point to core transcriptional control (DNA-templated transcription, negative regulation of transcription by RNA polymerase II) and chromatin remodeling, suggesting epigenetic regulation of gene expression. The additional differentiation-related terms across multiple lineages (dendritic cells, endocrine pancreas, skeletal muscle, forebrain glial cells, somatic stem cells, cardiac fate) imply these proteins influence development more broadly rather than a single tissue. Together, they indicate a cluster of transcriptional and chromatin-modifying factors involved in developmental programs and lineage specification.","confidence":"High","size":14,"edges":52,"triangles":89,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0000122","count":6},{"id":"GO:0043044","count":5},{"id":"GO:2001200","count":5},{"id":"GO:0031018","count":5}]},{"hash":"337655672966111761","title":"Spliceosome-Regulated mRNA Processing","description":"Most top GO terms cluster around regulation of mRNA splicing via the spliceosome (positive/negative regulation and alternative splicing) and related RNA processing activities (mRNA modification, stability, and processing). This points to proteins functioning in post-transcriptional gene regulation and RNA maturation, with a minor note of ncRNA-mediated gene silencing supporting RNA-based regulation. Overall, the cluster is best described by spliceosome-driven mRNA processing.","confidence":"High","size":14,"edges":45,"triangles":59,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":9},{"id":"GO:0048026","count":9},{"id":"GO:0010610","count":8},{"id":"GO:0048025","count":7},{"id":"GO:0000381","count":7}]},{"hash":"518646693286764186","title":"RNA Processing and Ribosome Biogenesis","description":"This cluster prominently features RNA-centric processes (ncRNA-mediated gene silencing, splicing regulation) and ribosome-related tasks (mitochondrial large ribosomal subunit assembly, rRNA processing), suggesting a core theme of RNA metabolism linked to ribosome biogenesis. Some terms are obsolete, but the main signal remains RNA processing and ribosome assembly.","confidence":"High","size":14,"edges":57,"triangles":125,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":14},{"id":"GO:0048026","count":14},{"id":"GO:0000464","count":8},{"id":"GO:1904574","count":8},{"id":"GO:0045003","count":8}]},{"hash":"1137995828710103911","title":"Developmental Gene Regulation and Apoptosis","description":"The cluster centers on transcriptional control (DNA-templated transcription, RNA Pol II regulation) and chromatin modification (histone methylation) with multiple developmental processes appearing in the top terms (skeletal muscle differentiation, TGF-beta signaling, oskar mRNA translation regulation, epithelial migration). It also includes apoptotic-related terms (mitochondrial membrane permeability, apoptotic process), suggesting a developmental program where gene regulation governs differentiation and cell survival. The breadth is coherent but not tightly linked to a single pathway, so it\u2019s best described as developmental gene regulation with apoptosis. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0035435","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0010452","count":2},{"id":"GO:0035914","count":2}]},{"hash":"1204847236491742357","title":"Cytoskeleton organization and polarity","description":"The top GO terms are dominated by cytoskeletal and adhesion-related functions (integrin activation, cytoskeletal anchoring, Rac signaling, microtubule anchoring) and polarity/axis specification, suggesting the proteins in this cluster are linked to cytoskeletal dynamics, cell adhesion, and polarity establishment. Some outlier terms exist, but the core theme points to cytoskeletal organization and polarity signaling.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033622","count":2},{"id":"GO:0007016","count":2},{"id":"GO:0002642","count":1},{"id":"GO:0032367","count":1},{"id":"GO:0030917","count":1}]},{"hash":"958740269270898380","title":"Broad Substrate Membrane Transporters","description":"The top GO terms are dominated by various transmembrane transport activities across many substrates (nitrite, galactose, arabinose, sialic acid, phosphate, vitamins, xenobiotics, etc.), suggesting a cluster of transporter proteins with broad or diverse substrate specificity rather than a single metabolic enzyme. This supports labeling the group as broad substrate membrane transporters.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0015739","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0006004","count":2}]},{"hash":"1750433953804079473","title":"Ubiquitin-Dependent Protein Degradation","description":"The top terms are dominated by ubiquitin-related processes (ubiquitin-dependent protein catabolic process, K33-linked ubiquitination, and regulation of protein ubiquitination), suggesting this cluster centers on ubiquitin-mediated protein turnover. Immune-related annotations (mast cell cytokine production, IgE isotype switching, dendritic cell differentiation) imply roles in immune signaling modulated by ubiquitination. Some terms appear noisy or obsolete, indicating annotation artifacts, but the core theme remains ubiquitin pathway regulation in immune contexts.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0032764","count":7},{"id":"GO:2000312","count":7},{"id":"GO:1904431","count":7},{"id":"GO:0045497","count":7}]},{"hash":"792557717815913567","title":"Unknown","description":"The top GO terms span unrelated areas (epoxygenase P450 pathway, lipid dephosphorylation, various biosynthetic and metabolic processes, metal ion transport, calcium homeostasis, and hormone response). There is no single dominant function or pathway connecting these proteins, and the absence of edges suggests a lack of coherent interaction. Therefore this cluster appears to be functionally diverse rather than a cohesive unit.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019373","count":1},{"id":"GO:0046839","count":1},{"id":"GO:0006564","count":1},{"id":"GO:0006874","count":1},{"id":"GO:0046272","count":1}]},{"hash":"1819608203231171011","title":"Ubiquitin-Mediated Signaling Regulation","description":"This cluster centers on ubiquitination and deubiquitination processes (protein ubiquitination, K63-linked deubiquitination, protein deubiquitination) and includes multiple entries related to the regulation of signaling pathways, such as TLR5, NOD1, Wnt, and apoptotic signaling. A few terms touch on developmental and metabolic processes (dorsal axis determination, insulin secretion), suggesting a broader theme of regulatory control of signaling and protein turnover. Overall, the strongest signal is ubiquitin- and signaling-regulation, with some peripheral metabolic/developmental terms.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048263","count":2},{"id":"GO:0061178","count":2},{"id":"GO:2000053","count":2},{"id":"GO:0036233","count":2},{"id":"GO:0034148","count":1}]},{"hash":"1303719424772093063","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006203","count":3},{"id":"GO:0042245","count":3},{"id":"GO:0001680","count":3},{"id":"GO:0006402","count":3},{"id":"GO:0006808","count":3}]},{"hash":"1847693368048701030","title":"Larval chitin-based cuticle development","description":"This cluster is dominated by the GO term larval chitin-based cuticle development, indicating involvement in forming the larval exoskeleton via chitin-containing cuticle proteins; the term strongly represents the cluster\u2019s likely function.","confidence":"High","size":14,"edges":89,"triangles":341,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":10}]},{"hash":"17247437227752147","title":"Mitochondrial Translation and Respiration","description":"The cluster shows GO terms centered on translation and mitochondrial energy metabolism: translation (GO:0006412) alongside mitochondrial electron transport (GO:0006120) and complex II assembly (GO:0034553), which together point to coordinated mitochondrial protein synthesis and oxidative phosphorylation. Additional terms related to cell cycle and RNA processing may reflect regulatory cross-talk, but the strongest signal ties to mitochondrial translation and respiration.","confidence":"High","size":14,"edges":89,"triangles":341,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:1903862","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0008284","count":1},{"id":"GO:1903705","count":1}]},{"hash":"1140299679585295424","title":"Adhesion and Polarity Dynamics","description":"The top GO terms cluster around podosome assembly and epithelial cell polarity, with related leukocyte adhesion and cytoskeletal remodeling signals. This suggests a common theme of cell\u2013cell adhesion and polarity with actin/cytoskeletal dynamics, supported by related trafficking terms (endosome transport). Some developmental terms are present but do not overwhelm the primary adhesion/polarity signal.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007398","count":1},{"id":"GO:0071800","count":1},{"id":"GO:0071320","count":1},{"id":"GO:0090162","count":1},{"id":"GO:0007159","count":1}]},{"hash":"711537526559783685","title":"Vascular tone regulation via GPCR signaling","description":"The dominant terms describe muscle relaxation, vasodilation, vascular permeability, prostaglandin signaling, smooth muscle regulation, angiotensin-mediated vascular responses, and GPCR-linked MAPK and cAMP pathways, indicating proteins involved in controlling vascular tone, smooth muscle function, and hormone signaling. While a reproductive term appears, the core theme centers on vascular regulation and signaling.","confidence":"High","size":14,"edges":27,"triangles":18,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090075","count":12},{"id":"GO:0043114","count":12},{"id":"GO:0071799","count":12},{"id":"GO:0045986","count":12},{"id":"GO:0046887","count":12}]},{"hash":"1023359452664447180","title":"RNA Pol II Transcription Regulation During Differentiation","description":"The top terms center on RNA polymerase II\u2013mediated transcription and its regulation, with several entries tied to transcription from Pol II promoters and DNA-templated transcription, plus signals related to differentiation (brown fat, osteoblast, macrophage) and growth factor/cytokine responses (IGF, IL-4). This suggests a cohesive theme of transcriptional control by RNA Pol II in differentiation and signaling contexts.","confidence":"High","size":14,"edges":90,"triangles":352,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":6},{"id":"GO:0071353","count":6},{"id":"GO:0006990","count":6},{"id":"GO:0045669","count":6},{"id":"GO:1990440","count":6}]},{"hash":"1565062541757793466","title":"Cellular stress response and signaling","description":"The top GO terms cluster around stress and damage response (response to toxic substances, positive regulation of apoptosis, prostaglandin signaling) and associated signaling/metabolic processes (ERK cascade, fatty acid oxidation, endosome transport). The sparse connectivity and mixture of terms suggest a broad, stress-related signaling cluster rather than a single pathway, so the label emphasizes the central theme of cellular stress signaling. ","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009636","count":4},{"id":"GO:0043433","count":3},{"id":"GO:0043065","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0019395","count":3}]},{"hash":"724682061637614216","title":"Plant metabolism and defense signaling","description":"This cluster contains multiple catabolic processes (amino acids, fatty acids) and vitamin biosynthesis (phylloquinone/menaquinone), along with a defense-related term (systemic acquired resistance) and a light/visual perception term, suggesting a broad theme of plant metabolic activity intertwined with defense and light-responsive signaling.","confidence":"Medium","size":14,"edges":15,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0009234","count":1},{"id":"GO:0006635","count":1},{"id":"GO:0042372","count":1}]},{"hash":"1422523108124110449","title":"Glutamatergic Neuronal Ion Transport and Signaling","description":"The cluster shows strong enrichment for ion transport (sodium, potassium, calcium) and the ionotropic glutamate receptor signaling pathway, along with a link to long-term synaptic depression, indicating a focus on glutamatergic neurotransmission and associated calcium-dependent signaling in neurons. Some terms also touch on behavior and development, but the core theme remains neural ion transport and glutamate signaling.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0060292","count":3},{"id":"GO:0035176","count":2},{"id":"GO:0010157","count":2}]},{"hash":"19726120936513587","title":"Cell-cycle and proteostasis regulation","description":"This cluster centers on the control of core cellular processes, including negative regulation of cyclin-dependent kinase activity, positive regulation of GTPase activity, proteasome regulatory particle assembly, and telomere maintenance\u2014tactors of cell-cycle progression, protein turnover, and genome stability. Additional terms on epithelial polarity and immune signaling suggest broader regulatory roles in cell architecture and communication, with stress responses (cold, vitamin D) appearing as peripheral themes. Overall, the proteins seem tied to regulated state maintenance rather than a single pathway.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045736","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0030433","count":2}]},{"hash":"543334302312414360","title":"Unknown","description":"The top terms cover transcription regulation, NF-kappaB regulation, mechanical stimulus response, vitamin D response, IgA isotype switching, serine phosphorylation signaling, peptide catabolism, and allantoin metabolism, with no clear shared pathway. The terms are mixed and several are obsolete, so there isn\u2019t a coherent functional theme to define a specific cluster name beyond Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":2},{"id":"GO:0032088","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0033280","count":2},{"id":"GO:0048298","count":2}]},{"hash":"2159838800090857578","title":"Neural development and signaling","description":"The top GO terms show several neural-related processes (neuron migration, motor learning, axon guidance) and broader developmental/signaling activities (cell maturation, seminiferous tubule development, growth hormone secretion, GPCR signaling). There isn\u2019t a single cohesive pathway linking all terms, and the edges are absent, so this label is a best-effort broad category rather than a precise function.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060732","count":1},{"id":"GO:0060124","count":1},{"id":"GO:0071329","count":1},{"id":"GO:0001764","count":1},{"id":"GO:0048105","count":1}]},{"hash":"1514531577170775709","title":"Inflammation-Related Signaling and Metabolism","description":"The top GO terms cluster around inflammatory response and chemokine production, alongside carbohydrate metabolic processes and chitin catabolism, with additional signals pointing to cytoskeletal dynamics and receptor internalization. Since there isn't a single cohesive function driving all terms, this label emphasizes the strongest recurring theme\u2014inflammation-related signaling coupled with metabolic activity\u2014while acknowledging the mixed nature of the terms. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005975","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0006032","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0090240","count":1}]},{"hash":"1442259287914314041","title":"Golgi\u2013ER Vesicle Trafficking","description":"Top GO terms cluster around vesicle transport between the Golgi and ER and Golgi organization (retrograde Golgi-to-ER, ER-to-Golgi, Cvt/vacuolar targeting). Some terms are peripheral (dsRNA transport, pollen tube growth, meristem transition, epithelial migration), but the dominant pattern supports a Golgi/ER trafficking theme.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000301","count":1},{"id":"GO:0033227","count":1},{"id":"GO:0007112","count":1},{"id":"GO:0009860","count":1},{"id":"GO:0007030","count":1}]},{"hash":"2217042184380550234","title":"Fish lateral-line sensory signaling and locomotion","description":"This cluster centers on neural signaling and sensory pathways relevant to fish: ion transport (sodium, potassium, calcium), ionotropic glutamate receptor signaling, olfactory learning, and development of the anterior lateral line, plus behavioral terms like social behavior and forward locomotion. These together suggest coordinated mechanosensory and neural signaling functions in fish, justifying a label focused on lateral-line\u2013related sensory signaling and locomotion.","confidence":"High","size":14,"edges":17,"triangles":4,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":8},{"id":"GO:0010157","count":8},{"id":"GO:0035725","count":8},{"id":"GO:0043056","count":8},{"id":"GO:0048899","count":8}]},{"hash":"1180351190469178613","title":"Unknown","description":"The top GO terms span vascular-related processes (blood coagulation, endothelial barrier establishment, smooth muscle cell migration) and proteolysis, but also plant-specific development (strigolactone biosynthetic process, secondary shoot formation) and sensory perception of sound. Because these terms do not converge on a single clear function for the cluster, the annotations appear heterogeneous, so a cohesive label is not warranted.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0007605","count":2},{"id":"GO:1903142","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0019391","count":2}]},{"hash":"2043298198374876749","title":"Embryogenesis and organogenesis","description":"Reason: The terms cluster around embryonic development and tissue specification\u2014left-right patterning, cartilage morphogenesis, placental/trophoblast differentiation, endocrine and pancreatic development, and EMT in heart development\u2014supported by transcriptional regulation and chromatin deubiquitination factors. This suggests a broad embryogenesis/organogenesis signature.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0060536","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0035270","count":2}]},{"hash":"471312852520293345","title":"Unknown","description":"The GO terms include nuclear processes (nucleosome assembly, chromosome condensation), protein ubiquitination, and diverse developmental/immune signals (BMP pathway, B cell differentiation, intestinal stem cell homeostasis, endothelial barrier), with no shared function or interactions among the proteins, so a single cohesive theme cannot be determined.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":1},{"id":"GO:0030261","count":1},{"id":"GO:0051260","count":1},{"id":"GO:0016567","count":1},{"id":"GO:0070236","count":1}]},{"hash":"2096743931533058020","title":"Actin Remodeling and Immune Cell Migration","description":"Dominant terms center on lamellipodium assembly and Rho signaling, indicating actin cytoskeleton remodeling. The presence of dendritic cell chemotaxis and vascular permeability fits with immune cell movement and barrier regulation, suggesting a cohesive module of cytoskeletal dynamics driving immune cell migration.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030032","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0002408","count":4},{"id":"GO:0007601","count":3},{"id":"GO:0043114","count":3}]},{"hash":"192148287478437055","title":"Redox Homeostasis and Oxidative Stress Response","description":"The cluster is dominated by GO terms related to oxidative stress management and redox balance, including cellular redox homeostasis, oxidative stress response, oxidant detoxification, and removal of superoxide radicals, as well as protein deglutathionylation and cytochrome complex assembly, all pointing to mitochondrial/enzymatic control of the cellular redox state. Some terms (methylamine metabolism, pituitary development, and a deprecated oxidation-reduction term) appear ancillary or unrelated, suggesting minor noise. Overall, the core theme centers on protecting the cell from oxidative damage and maintaining redox homeostasis.","confidence":"High","size":13,"edges":61,"triangles":165,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0045454","count":5},{"id":"GO:0098869","count":4},{"id":"GO:0019430","count":3},{"id":"GO:0030416","count":3}]},{"hash":"293464626098520685","title":"Actin Cytoskeleton in Muscle and Synapse","description":"Dominant terms are about actin dynamics and cytoskeletal organization, including actin filament polymerization, sarcomere organization, skeletal muscle fiber adaptation, and postsynaptic actin cytoskeleton organization, indicating a cluster of proteins involved in actin remodeling in muscle and neural contexts (with some miscellaneous annotations). ","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0030476","count":12},{"id":"GO:0002121","count":12},{"id":"GO:0042766","count":12},{"id":"GO:0032508","count":12},{"id":"GO:0045214","count":12}]},{"hash":"276491433362799046","title":"Developmental transcriptional regulation","description":"The cluster features GO terms for transcriptional regulation (negative regulation of transcription by RNA polymerase II; DNA-templated transcription) alongside broad developmental processes (brain, pancreas, gonad, cranial skeleton). This suggests proteins that control gene expression during embryonic development across multiple tissues, rather than a single tissue-specific function.","confidence":"Medium","size":13,"edges":5,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0006351","count":5},{"id":"GO:0030901","count":5},{"id":"GO:0008584","count":5},{"id":"GO:0007338","count":5}]},{"hash":"897531834460660212","title":"Developmental signaling and cell adhesion","description":"This cluster centers on developmental processes and signaling pathways (post-embryonic development, multicellular organism growth, Wnt signaling, PI3K/AKT), with an emphasis on cell\u2013cell adhesion, suggesting roles in tissue formation and coordination of intercellular communication. Although some GO terms touch on immune or behavioral aspects, the strongest signals point to a developmental signaling/adhesion theme. Confidence in a representative label is Medium.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009791","count":2},{"id":"GO:0071333","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0035754","count":2}]},{"hash":"1271931564324322539","title":"Ubiquitin-Dependent Vesicle Trafficking and Degradation","description":"This cluster is best described as ubiquitin-regulated protein turnover in vesicle trafficking. The strongest signals are ubiquitin-dependent degradation (ubiquitin-dependent protein catabolic process, polyubiquitination, ERAD) and vesicle transport (anterograde synaptic vesicle transport, ER-Golgi transport). Some immune terms exist but do not define the main theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048490","count":3},{"id":"GO:0006888","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0097039","count":2},{"id":"GO:0071157","count":2}]},{"hash":"155249393201703967","title":"Neural development and calcium signaling","description":"Based on the GO terms, the cluster centers on neural tissue development (substantia nigra, retinal cone cells, Schwann cells, multicellular organism development) and calcium-dependent processes (calcium detection, SR-mediated calcium release) along with neural signaling activity (excitatory postsynaptic potential, epinephrine response). This suggests a coherent theme of neural development coupled with calcium-mediated signaling pathways.","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035690","count":8},{"id":"GO:0060079","count":6},{"id":"GO:0086004","count":6},{"id":"GO:0046549","count":6},{"id":"GO:0010880","count":6}]},{"hash":"1249813073860864551","title":"Spinal Cord Neuron Differentiation and Axon Guidance","description":"The top terms point to neuronal development in the spinal cord (spinal cord association neuron differentiation, ventral spinal cord interneuron specification, motor neuron axon guidance) and related brain regions (Purkinje cell differentiation), with supporting signaling roles (receptor guanylyl cyclase signaling). Although some terms are more peripheral, the dominant theme is neuron differentiation and axon pathfinding in the central nervous system.","confidence":"High","size":13,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021527","count":3},{"id":"GO:0007168","count":3},{"id":"GO:2000768","count":3},{"id":"GO:0008045","count":3},{"id":"GO:0008588","count":3}]},{"hash":"1816164084795125131","title":"Mitochondrial transport and energy metabolism","description":"The GO terms are centered on mitochondrial processes: transmembrane transport of various metabolites (nucleotides, amino acids, phosphate, thiamine pyrophosphate), regulation of mitochondrial membrane potential, the malate-aspartate shuttle, mitochondrial membrane fission, and adaptive thermogenesis. This pattern points to a cluster of proteins involved in mitochondrial metabolite transport and overall energy metabolism/dynamics rather than a single substrate or isolated pathway.","confidence":"High","size":13,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000066","count":2},{"id":"GO:0034198","count":2},{"id":"GO:0051881","count":2},{"id":"GO:0035435","count":2},{"id":"GO:0030302","count":2}]},{"hash":"275405741470435078","title":"Ribosome biogenesis and translation","description":"Top GO terms indicate core protein synthesis machinery: translation, ribosomal large subunit biogenesis, and rRNA processing. While a few other terms touch on stress responses or cell cycle, the strongest and most frequent signals center on ribosome assembly and protein synthesis, justifying a label focused on ribosome biogenesis and translation.","confidence":"High","size":13,"edges":16,"triangles":20,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0042273","count":2},{"id":"GO:0006364","count":2},{"id":"GO:0017085","count":1},{"id":"GO:1900186","count":1}]},{"hash":"1892084955046039644","title":"Potassium Transport and Membrane Potential Regulation","description":"The top terms cluster around potassium ion transport (import/export) and maintenance of membrane potential, including intracellular potassium homeostasis and stabilization of membrane potential. This suggests a coherent function in regulating cellular excitability via potassium channels/transporters, with supportive signals like cAMP and occasional sensory/immune associations, but the potassium/homeostasis theme is strongest.","confidence":"High","size":13,"edges":11,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010754","count":3},{"id":"GO:0097623","count":3},{"id":"GO:0030322","count":3},{"id":"GO:0030007","count":3},{"id":"GO:0051260","count":3}]},{"hash":"1056618443272516184","title":"Larval cuticle development","description":"The only strong annotation present is GO:0008363 (larval chitin-based cuticle development), suggesting the cluster may be linked to larval cuticle formation or regulation. However, with just a single GO term among 13 proteins and no broader shared annotations, the connection is tentative and other proteins\u2019 functions remain unclear. Therefore, this label is a cautious, representative guess about a possible shared function.","confidence":"Low","size":13,"edges":57,"triangles":116,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1}]},{"hash":"1135220261211782271","title":"Organogenesis Across Tissues","description":"The top GO terms reflect development and differentiation across multiple tissues (retina, thyroid, bone/osteoblasts, muscle, spinal cord neurons, forebrain neuron commitment, kidney branching) rather than a single tissue function, indicating a broad organogenesis/differentiation theme suitable for this cluster.","confidence":"Medium","size":13,"edges":69,"triangles":198,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":9},{"id":"GO:0002087","count":7},{"id":"GO:0002076","count":7},{"id":"GO:0021527","count":5},{"id":"GO:0030878","count":5}]},{"hash":"1420054774147705212","title":"Wnt-driven patterning and signaling regulation","description":"The cluster is enriched for left/right pattern formation and Wnt signaling terms, indicating involvement in developmental patterning and signal transduction. Supporting terms such as ubiquitin-dependent proteolysis, GTPase activity regulation, and cell cycle/apoptosis point to broader regulatory roles in protein turnover and cell fate decisions. Some immune-related terms and obsolete annotations may be noise or reflect multifunctional proteins.","confidence":"Medium","size":13,"edges":10,"triangles":10,"max_degree":4,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0002669","count":5},{"id":"GO:0031064","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0042787","count":5}]},{"hash":"1079131260493472562","title":"Transmembrane transporters for nutrients and metals","description":"The cluster\u2019s top GO terms are dominated by diverse transmembrane transport activities, covering xenobiotic and vitamin transport, heme and cobalt ion transport, phosphate ion transport, branched-chain amino acid transport, mitochondrial oligopeptide export, and lipoprotein transport. This convergence on membrane-transport functions across various substrates indicates a coherent theme of transporter proteins handling nutrients, ions, and related molecules. Confidence is High.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":9},{"id":"GO:0035461","count":9},{"id":"GO:0015886","count":7},{"id":"GO:0042891","count":6},{"id":"GO:0035435","count":6}]},{"hash":"1530471401378283750","title":"Nuclear envelope and developmental signaling regulators","description":"The Top Terms point to nuclear envelope processes (meiotic telomere attachment, nuclear inner membrane organization, protein export from nucleus) alongside developmental roles (heart formation, CNS development, endothelial migration) and regulation of major signaling pathways (Wnt, BMP, PI3K/AKT). This suggests a coherent theme of proteins linking nuclear architecture with developmental signaling during tissue formation.","confidence":"Medium","size":13,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070197","count":2},{"id":"GO:0035414","count":2},{"id":"GO:0060914","count":2},{"id":"GO:0035307","count":2},{"id":"GO:0007417","count":2}]},{"hash":"1365600550463526375","title":"Ubiquitin-dependent Regulation of Transcription and Apoptosis","description":"The cluster shows enrichment for negatively regulating transcription by RNA polymerase II, regulating apoptotic processes, and ubiquitin-dependent protein degradation (including K48-linked ubiquitination), along with related signals such as NF-\u03baB pathway activation and cell cycle regulation. This points to a cohesive theme where ubiquitin signaling modulates gene expression and cell fate, with possible ties to immune-related processes (e.g., V(D)J recombination).","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0042981","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0090073","count":2},{"id":"GO:0043066","count":2}]},{"hash":"1323292107290836508","title":"Glycinergic Synaptic Signaling and Serotonin Regulation","description":"The cluster shows a strong enrichment for glycinergic synaptic transmission and glycine transport (glycinergic transmission, glycine import), plus serotonin-related processes (serotonin secretion and uptake) and neural development signals (thalamus development) along with perineurial glial growth. This points to a cohesive theme of nervous system signaling, especially glycine- and serotonin-mediated communication, with supporting glial development. The protoporphyrinogen IX biosynthetic term is less aligned and may reflect a broader metabolic background but does not override the main nervous system signaling pattern. Confidence: High","confidence":"","size":13,"edges":8,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006782","count":3},{"id":"GO:0042066","count":2},{"id":"GO:1905847","count":2},{"id":"GO:0015824","count":2},{"id":"GO:0036233","count":2}]},{"hash":"895561633590652145","title":"Nervous system signaling and plasticity","description":"The proteins in this cluster show GO terms largely related to neuronal communication and plasticity: excitatory postsynaptic potential, calcium ion transport, GPCR signaling pathways, kinase regulation, memory, and peripheral nervous system myelination. A few terms (SA node regulation, heat response, surfactant homeostasis) are less central but may reflect broader excitability or stress responses. Overall, the cluster seems to capture neural signaling and plasticity processes.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":3},{"id":"GO:0009408","count":3},{"id":"GO:0098907","count":2},{"id":"GO:0007616","count":2},{"id":"GO:0043129","count":2}]},{"hash":"1894626331066814306","title":"Neural development and synaptic signaling","description":"These proteins are linked mostly to neural development and synaptic signaling: brain and nervous system development, regulation of synaptic vesicle exocytosis, axon guidance (Roundabout), Hedgehog/Smoothened signaling, and general brain development. An outlier term (T cell receptor signaling) is immune-related, but the dominant enrichment supports a neural development and signaling cluster.","confidence":"High","size":13,"edges":69,"triangles":201,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":8},{"id":"GO:0007399","count":8},{"id":"GO:2000300","count":8},{"id":"GO:0001822","count":8},{"id":"GO:0007224","count":8}]},{"hash":"1298168717672502758","title":"Embryonic Development and Organogenesis","description":"The top GO terms cluster around embryonic patterning and tissue formation: cartilage morphogenesis, left/right patterning, placental and endocrine development, heart-related EMT, and pancreatic development, with Wnt signaling as a common developmental pathway. While ceramide biosynthesis and transcriptional regulation appear, the dominant signal is broad embryogenesis and organogenesis, spanning multiple tissues. This name captures the central theme without tying to a single tissue.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0060806","count":3}]},{"hash":"582649832029876399","title":"Amino acid catabolism and energy metabolism","description":"The top terms indicate multiple amino acid catabolic pathways (alanine, kynurenine/tryptophan, lysine) and core energy metabolism (glyoxylate, TCA cycle), along with a starvation response and liver development. Notch signaling is also present, which may reflect developmental context in the liver. Together these terms suggest a cluster centered on amino acid breakdown and energy production with a liver-development link.","confidence":"Medium","size":13,"edges":73,"triangles":238,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019878","count":5},{"id":"GO:0042853","count":5},{"id":"GO:0007219","count":5},{"id":"GO:0097053","count":5},{"id":"GO:0009436","count":4}]},{"hash":"321429681173523111","title":"Vascular Tone Regulation via GPCR Signaling","description":"This cluster centers on smooth muscle relaxation and vasodilation, with GO terms such as relaxation of muscle, regulation of vascular permeability, angiotensin-mediated vasodilation, prostaglandin response, and cAMP/PKA signaling, all pointing to cardiovascular signaling that controls vessel tone and hormone-driven vascular responses. ERK signaling involvement suggests linked growth-factor\u2013like modulation of these vascular processes. Overall, it reflects vascular regulation and hormone-mediated blood pressure control.","confidence":"High","size":13,"edges":33,"triangles":34,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090075","count":12},{"id":"GO:0043114","count":12},{"id":"GO:0071799","count":12},{"id":"GO:0045986","count":12},{"id":"GO:0046887","count":12}]},{"hash":"2204945481591096430","title":"Triglyceride catabolism and lipid remodeling","description":"The cluster is dominated by GO terms involving triglyceride catabolic processes (including mobilization and acyl-chain remodeling) and phospholipid catabolism (phosphatidylcholine and phosphatidylethanolamine). This points to a shared function in lipid breakdown and membrane remodeling. A couple of terms (acrosome reaction, sensory stimulus detection) may relate to membrane dynamics or exocytosis, but the strongest signal is lipid metabolism.","confidence":"High","size":13,"edges":24,"triangles":7,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0034638","count":3},{"id":"GO:0010898","count":3},{"id":"GO:0036153","count":3},{"id":"GO:0019433","count":3},{"id":"GO:2000480","count":3}]},{"hash":"2219936875698724916","title":"Protein oligomerization and metabolic catabolism","description":"These proteins show enrichment for protein complex formation/dynamics (positive regulation of oligomerization, homotetramerization, heterooligomerization) and proteostasis (ubiquitin recycling), plus hormone catabolic processes (bradykinin, insulin) and energy metabolism (aerobic respiration, mitochondrial electron transport). The cluster thus spans protein complex assembly and metabolic catabolism, linking proteostasis with cellular energetics.","confidence":"Medium","size":13,"edges":18,"triangles":6,"max_degree":11,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0032461","count":4},{"id":"GO:0010992","count":4},{"id":"GO:0008340","count":4},{"id":"GO:0042447","count":4},{"id":"GO:0006122","count":4}]},{"hash":"699723630608678704","title":"Myogenesis and Skeletal Development Signaling","description":"This cluster is enriched for terms related to positive regulation of ERK/MAPK signaling, BMP signaling, and myoblast differentiation, alongside skeletal system development, which together point to signaling processes that drive muscle formation and bone development. Some outlier terms (sporulation, sperm capacitation, transport) appear unrelated but do not override the core theme of muscle/bone developmental signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0030513","count":2},{"id":"GO:0045663","count":2},{"id":"GO:0048661","count":2}]},{"hash":"2241657124614872489","title":"Unknown","description":"The top terms are diverse, spanning immune regulation, host\u2013symbiont interactions, chromatin/epigenetic processes, cell polarity, proteasome assembly, and stress responses, with no single unifying function. There are no edges or cohesive pathway signals to tie the proteins together, and some terms are obsolete, suggesting annotation noise rather than a shared biological module. Therefore, Unknown with no clear confidence in a specific label.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010745","count":3},{"id":"GO:0046718","count":2},{"id":"GO:1904357","count":2},{"id":"GO:0010424","count":2},{"id":"GO:0090162","count":2}]},{"hash":"557864608154134728","title":"Embryonic Development and Transcription Regulation","description":"Proteins here are enriched for developmental GO terms (forebrain development, neural tube closure, multicellular organism development, skeletal system development) and transcription-related processes (DNA-templated transcription). While there are some cell-cycle and stress-response terms present, the developmental signals predominate, suggesting a cluster centered on developmental regulation.","confidence":"Medium","size":13,"edges":7,"triangles":0,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030900","count":9},{"id":"GO:0000278","count":8},{"id":"GO:0071276","count":8},{"id":"GO:0001403","count":7},{"id":"GO:0007275","count":7}]},{"hash":"1240727150902579043","title":"Telomere maintenance regulation and telomeric localization","description":"Most terms cluster around telomere biology: positive and negative regulation of telomere maintenance via telomerase, telomere capping, and localization to telomeric regions. A few other terms (ubiquitination, innate immune response, spindle assembly, Wnt signaling) may reflect broader regulatory roles or annotation noise, but they do not redefine the main theme. The dominant signal is regulation of telomere length and protection at telomeres, suggesting a telomere maintenance/regulation module.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0045087","count":2},{"id":"GO:1904357","count":2},{"id":"GO:0051225","count":2},{"id":"GO:0016055","count":2}]},{"hash":"1549928536751438811","title":"Membrane Trafficking and Cell Polarity","description":"The prominent GO terms point to Golgi-to-plasma membrane transport, protein transmembrane transport, and establishment/maintenance of apical/basal polarity, with supporting signaling and GTPase regulation, indicating a cluster focused on secretory trafficking combined with polarity control.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006893","count":2},{"id":"GO:0030011","count":2},{"id":"GO:0001998","count":1},{"id":"GO:0071806","count":1},{"id":"GO:0048013","count":1}]},{"hash":"1471793391715533082","title":"DNA Repair and Stress Response","description":"The cluster is anchored by DNA maintenance terms (base-excision repair, DNA recombination, DNA catabolic process), pointing to genome integrity surveillance. It also includes stress-related terms (response to xenobiotic stimulus, redox homeostasis, cellular response to cAMP), suggesting a broader role in stress signaling alongside DNA repair. A corneocyte development term appears but is less central to the core theme. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042493","count":3},{"id":"GO:0003335","count":3},{"id":"GO:0071320","count":3},{"id":"GO:0006284","count":3},{"id":"GO:0007568","count":3}]},{"hash":"341404409754117797","title":"Neural signaling and ion transport","description":"The terms point to neural communication and modulation (serotonin metabolism, social behavior, regulation of protein kinase activity) combined with ion transport (sodium, potassium, calcium) and locomotor/sensory development (forward locomotion, lateral line development). This pattern suggests a cluster centered on neural signaling pathways that rely on ion homeostasis to drive movement and sensory function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":2},{"id":"GO:0042428","count":1},{"id":"GO:0035176","count":1},{"id":"GO:0010157","count":1},{"id":"GO:0035725","count":1}]},{"hash":"1633191049668381181","title":"Unknown","description":"The top GO terms are diverse, including immune signaling (type I interferon production, NLRP3 inflammasome regulation), muscle/heart signaling and development (striated muscle development, Purkinje-to-ventricular signaling), membrane repair, synapse assembly, and membrane transporter activity. With no dominant shared function or pathway and no edges linking the proteins, there isn\u2019t a coherent theme to name a specific cluster; thus an Unknown label with None confidence is appropriate.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901896","count":1},{"id":"GO:0046598","count":1},{"id":"GO:0032479","count":1},{"id":"GO:0055002","count":1},{"id":"GO:0001778","count":1}]},{"hash":"61751718796038219","title":"Amino acid and polyamine membrane transport","description":"The top GO terms point to transport of amino acids (arginine, lysine) and related metabolites (polyamines, GABA, D-serine, carnitine) across the plasma membrane, along with a nod to osmoregulatory processes like cell volume homeostasis. This pattern suggests a cluster of membrane transporters for amino acids and related compounds. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902274","count":1},{"id":"GO:0097639","count":1},{"id":"GO:0006884","count":1},{"id":"GO:0035826","count":1},{"id":"GO:0097638","count":1}]},{"hash":"2202059477444566330","title":"Ubiquitin-Dependent Immune Regulation","description":"The cluster\u2019s GO terms prominently involve ubiquitination pathways (ubiquitin-dependent protein catabolic process, K33-linked ubiquitination, regulation of ubiquitination) and immune-related processes (mast cell cytokine production, dendritic cell differentiation, IgE isotype regulation), indicating a theme of ubiquitin-mediated control of immune signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032764","count":2},{"id":"GO:0042787","count":2},{"id":"GO:2000312","count":2},{"id":"GO:1904431","count":2},{"id":"GO:0045497","count":2}]},{"hash":"1156120331884333205","title":"TOR-Mediated Growth and Turnover in Development","description":"The top GO terms cluster around TOR signaling and nutrient sensing (amino acid response, positive regulation of TOR), alongside protein turnover processes (K11-linked ubiquitination, APC-dependent catabolism) and development-related differentiation (heart development, keratinocyte differentiation), suggesting a coherent theme of growth control and proteostasis in development.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0000186","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0032008","count":2},{"id":"GO:0043547","count":2}]},{"hash":"656045300839068468","title":"Plant light signaling and circadian regulation","description":"This cluster is dominated by GO terms tied to light cues and timing: photoperiodism, photoperiod entrainment, photoprotection, photoreactive repair, and shade-avoidance/flowering responses linked to light signaling. Together they point to a group of proteins involved in sensing light and regulating the circadian clock and photomorphogenic growth, with strigolactone signaling and flowering as downstream outputs. A few terms (e.g., glucocorticoid-related) appear as off-target annotations but do not obscure the primary plant light-regulation theme.","confidence":"High","size":12,"edges":29,"triangles":16,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0048574","count":3},{"id":"GO:2000850","count":3},{"id":"GO:1901332","count":3},{"id":"GO:1902347","count":3},{"id":"GO:1902448","count":3}]},{"hash":"2260126521684494541","title":"Neural development and axon guidance","description":"The top GO terms cluster around nervous system development, synapse organization, and axon guidance pathways (Roundabout/ROBO and Smoothened). Paranode localization of axon proteins further supports a role in neural patterning and synaptic organization during development, with broader developmental processes also represented. This combination points to a neural development and axon guidance theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043931","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0001822","count":8},{"id":"GO:0007224","count":8},{"id":"GO:0035385","count":8}]},{"hash":"505229609905913638","title":"Endosomal-Exosomal Trafficking and Biogenesis","description":"This cluster centers on vesicle formation and trafficking within the endosomal-lysosomal system, highlighted by multivesicular body assembly, endosome-to-lysosome transport, and exosomal secretion. Supporting terms for membrane transport and receptor signaling, plus regulation of GTPase activity and unfolded protein response, reinforce a cohesive theme of endosomal/exosomal sorting and release. ","confidence":"High","size":12,"edges":7,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0036258","count":6},{"id":"GO:0008333","count":6},{"id":"GO:1990182","count":6},{"id":"GO:0001998","count":5},{"id":"GO:0071806","count":5}]},{"hash":"237640034888803291","title":"Neural development and vesicle trafficking signaling","description":"This cluster centers on nervous system development, ephrin and Wnt signaling, and ERK/MAPK cascades, indicating coordinated neuronal differentiation and signaling. It also shows calcium-dependent exocytosis and endosome transport, pointing to vesicle trafficking essential for neurotransmitter release and receptor trafficking in neurons, with additional focal adhesion and axonogenesis regulation that relate to neurite outgrowth and guidance.","confidence":"High","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043552","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0045956","count":5}]},{"hash":"1370369507538851933","title":"Cell cycle regulation and transcription control","description":"This cluster features GO terms tied to cell cycle progression (G1/S transition, spindle pole body separation, mitotic cycles) and transcriptional regulation (Pol II and Pol III\u2013related transcription, SN RNA transcription), along with ubiquitin-mediated proteolysis. While it also touches on broader signaling and stress responses, the strongest signals point to nuclear processes coordinating cell division and gene expression, justifying a label around cell cycle regulation and transcription control.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0006384","count":1},{"id":"GO:0060070","count":1},{"id":"GO:0000082","count":1},{"id":"GO:0060153","count":1}]},{"hash":"2043415700310378727","title":"Unknown","description":"The top GO terms are highly diverse across species and processes, including translation regulation, viral replication interactions, mRNA stability, plant immune response, nematode biology, reproduction, muscle development, embryonic morphogenesis, and proteolysis. With no shared pathway or function evident, and no edges connecting proteins, there is no coherent theme tying the cluster together. Consequently, there is insufficient basis to assign a specific, representative label.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903679","count":1},{"id":"GO:0044829","count":1},{"id":"GO:0043488","count":1},{"id":"GO:0034052","count":1},{"id":"GO:1900363","count":1}]},{"hash":"1447368082116244860","title":"Mitochondrial Translation and Inner Membrane Biogenesis","description":"The GO terms cluster around mitochondrial gene expression and assembly, including mitochondrial translation, protein import into the mitochondrial matrix, inner mitochondrial membrane organization, and biogenesis of the respiratory chain complex IV. Additional mitochondrial-associated biosynthetic processes (heme and thiamine) reinforce a mitochondrial-focused theme, indicating this cluster represents mitochondrial translation and membrane/complex biogenesis functions.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0048240","count":2},{"id":"GO:0009228","count":2},{"id":"GO:0006782","count":2},{"id":"GO:0055114","count":2}]},{"hash":"1620859869158882599","title":"Unknown","description":"The top GO terms span chitin catabolic process, inflammatory mediator production, carbohydrate metabolism, chemokine regulation, and various development processes, with no evident shared function or pathway and no edges between proteins. This lack of cohesive theme justifies labeling as Unknown.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0010923","count":2}]},{"hash":"1357362887276954598","title":"Nuclear RNA and ribosomal export with transcription regulation","description":"The top GO terms cluster around nucleocytoplasmic transport: mRNA export, ribosomal subunit export, and general protein export from the nucleus, plus negative regulation of transcription by RNA Pol II. This points to a module of nuclear transport and transcriptional control factors. Some terms ( xenobiotic response, cell differentiation) are present but less central, suggesting a core theme of nuclear trafficking and gene expression regulation rather than a single specialized process.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":4},{"id":"GO:0000055","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0035048","count":3},{"id":"GO:0000122","count":3}]},{"hash":"706990928124102610","title":"Unknown","description":"The top terms span diverse processes (larval cuticle development, chromatin regulation, autophagy, sensory organ fate, blood cell differentiation, immune regulation, and estrogen response) with several obsolete terms, showing no cohesive functional theme. This heterogeneity makes a single, representative label impractical.","confidence":"","size":12,"edges":15,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0000183","count":1},{"id":"GO:0016239","count":1},{"id":"GO:0043982","count":1},{"id":"GO:0001207","count":1}]},{"hash":"2004665991011634236","title":"Translation and ER-Golgi Transport","description":"The proteins show both translation-related terms (translation, translational elongation, methionyl-tRNA aminoacylation, tRNA processing, translational fidelity) and vesicle transport between the endoplasmic reticulum and Golgi (ER-to-Golgi and Golgi-to-ER). This suggests a cluster linked to both protein synthesis and the secretory pathway, rather than a single purely defined function, hence a combined label. There are some additional terms (ionizing radiation response, blood vessel morphogenesis) that are less represented and may reflect multifunctional annotations or noise.","confidence":"Medium","size":12,"edges":33,"triangles":42,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0006890","count":2},{"id":"GO:1990145","count":1},{"id":"GO:0032232","count":1},{"id":"GO:0006414","count":1}]},{"hash":"1771409364356535738","title":"RNAi-Driven Developmental Regulation","description":"The cluster\u2019s top GO terms point to RNA interference and post-transcriptional gene silencing (primary miRNA processing, regulatory ncRNA-mediated silencing, ds-siRNA processing) along with antiviral defense, while several terms emphasize development and morphogenesis (body morphogenesis, chitin-based cuticle development, neural development). This suggests the proteins collectively participate in RNAi pathways that regulate developmental gene expression and related immune responses. Overall, it seems to capture RNAi machinery tied to development and antiviral defense contexts, rather than a single, narrow function. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010171","count":3},{"id":"GO:0040003","count":3},{"id":"GO:0031053","count":1},{"id":"GO:0045071","count":1},{"id":"GO:0033168","count":1}]},{"hash":"181312790849405416","title":"Developmental signaling and cytoskeletal regulation","description":"The top GO terms point to developmental processes (brain development, osteoblast differentiation) and broad regulatory roles (positive regulation of apoptosis and cell cycle, GTPase activity regulation). Additional terms highlight cytoskeletal organization (localization to cortical microtubule cytoskeleton) and signaling cascades (IP3 biosynthesis, responses to salt stress, phagocytosis regulation). Together, these suggest a cluster of regulators coordinating developmentally relevant signaling and cytoskeletal dynamics rather than a single specific process.","confidence":"Medium","size":12,"edges":9,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0043065","count":3},{"id":"GO:0072699","count":3},{"id":"GO:2001235","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1727564299996458875","title":"Hormone-regulated transcription and differentiation","description":"The cluster centers on transcriptional control (DNA-templated transcription, transcription regulation, chromatin modification via histone deacetylation) and hormone signaling (estradiol response, androgen receptor pathway), with downstream effects on development and tissue remodeling (osteoblast differentiation, pancreatic cell development, wound healing). While a few terms seem broad or cross-species, the dominant theme is steroid hormone\u2013influenced transcriptional regulation tied to differentiation processes.","confidence":"High","size":12,"edges":64,"triangles":201,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0070932","count":8},{"id":"GO:1903715","count":7},{"id":"GO:0060766","count":7},{"id":"GO:0045668","count":7}]},{"hash":"948398575463441534","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0050830","count":3}]},{"hash":"266182045351965060","title":"Ribosome biogenesis and translation regulation","description":"The cluster's top GO terms center on translation and ribosome-related processes: translation, translational termination, ribosome biogenesis, and ribosomal large subunit assembly, plus regulation of cytoplasmic translation and translational elongation. Additional terms reference the antibiotic response and the stringent response, which often accompany shifts in ribosome production and translational control during stress. Together, these terms point to a cohesive group of proteins involved in ribosome assembly and the regulation of translation.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":9},{"id":"GO:0006415","count":5},{"id":"GO:0045903","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0000027","count":3}]},{"hash":"702105428307179213","title":"Phosphatidylinositol biosynthesis and ABA stress signaling","description":"The cluster is dominated by GO terms for phosphatidylinositol/inositol biosynthesis and related metabolic processes, plus ABA-activated signaling and hyperosmotic salinity response, which together suggest a plant-specific metabolic and stress-response module. Some terms (cartilage morphogenesis, left/right pattern formation) are outliers and may reflect cross-species annotation noise, but the strongest signal centers on PI/inositol metabolism and ABA-mediated osmotic stress signaling.","confidence":"Medium","size":12,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006661","count":3},{"id":"GO:0046854","count":3},{"id":"GO:0000103","count":3},{"id":"GO:0046855","count":3},{"id":"GO:0006094","count":3}]},{"hash":"175637929006284162","title":"Cilium- and Photoreceptor Protein Turnover","description":"The top GO terms point to cilium-related processes (non-motile cilium assembly, protein localization to photoreceptor outer segment) and protein turnover (K11-linked ubiquitination, APCC-dependent catabolic process), suggesting a theme of ciliary proteostasis and photoreceptor maintenance. Some terms (e.g., certain signaling pathways) seem less directly connected, likely representing broader annotations for a subset of proteins. Overall, the cluster can be succinctly labeled around cilium/photoreceptor localization and turnover.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006478","count":2},{"id":"GO:2000324","count":2},{"id":"GO:1902391","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0031145","count":2}]},{"hash":"2067337856596184598","title":"Cytokine signaling and inflammatory response","description":"The GO terms cluster around immune and cytokine signaling processes: cellular response to LPS, regulation of type II interferon and IL-5 production, and responses to M-CSF and TGF-beta stimuli. This pattern suggests the proteins participate in cytokine-mediated inflammatory signaling, with a few unrelated terms (serotonin metabolism, oocyte development) likely representing incidental associations. ","confidence":"Medium","size":12,"edges":25,"triangles":14,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0033159","count":3},{"id":"GO:0042428","count":3},{"id":"GO:0060282","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0032729","count":3}]},{"hash":"1256103547360387789","title":"Immune Signaling and Development Regulators","description":"This cluster centers on innate immune processes (innate immune response and regulation of NK cell cytotoxicity) and includes several signaling regulators (ERK cascade, GTPase activity, and serine phosphorylation) along with developmental terms (bone and heart development). The common theme appears to be modulators of immune signaling that also participate in developmental signaling pathways, rather than a single, canonical effector function.","confidence":"Medium","size":12,"edges":4,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045953","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0060348","count":4}]},{"hash":"1949439231011474081","title":"Unknown","description":"The terms span diverse and largely unrelated processes (thyroid development, brown fat differentiation, pollen recognition, various signaling pathways, and cell-cycle checkpoints), with several obsolete GO entries, indicating no cohesive functional theme for this cluster.","confidence":"","size":12,"edges":6,"triangles":2,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0030878","count":12},{"id":"GO:0071507","count":12},{"id":"GO:0036120","count":12},{"id":"GO:0090336","count":12},{"id":"GO:0048013","count":12}]},{"hash":"1089156425781340740","title":"B cell signaling and immune adhesion","description":"The cluster is dominated by immune-related GO terms: innate and adaptive immune responses, and specifically B cell receptor signaling, plus associations with interleukin-2 production and cell adhesion. While there are a couple developmental terms (heart development, neuron migration) that are less central, the strongest signal centers on immune signaling and adhesion processes, suggesting proteins involved in immune cell communication and interaction. ","confidence":"Medium","size":12,"edges":8,"triangles":0,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0043552","count":5},{"id":"GO:1900042","count":5},{"id":"GO:0002250","count":5}]},{"hash":"437511683230081695","title":"Inflammatory signaling and NF-kappaB pathway","description":"The cluster is dominated by terms tied to inflammation and immune signaling, notably inflammatory response and positive regulation of non-canonical NF-kappaB signaling, with supporting terms like phosphorylation and host autophagy activation. While some terms (bone development, synaptic transmission, yeast response) are less directly connected, the core appears to be immune-related signaling. Confident that the main theme is inflammatory signaling, with NF-kappaB involvement.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0060348","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0042346","count":2},{"id":"GO:0016310","count":2}]},{"hash":"915907593503526790","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0050909","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0070979","count":2}]},{"hash":"862948669402764564","title":"Cytochrome P450 Xenobiotic and Lipid Metabolism","description":"Top GO terms collectively point to cytochrome P450\u2013driven oxidation processes, including epoxygenase and omega-hydroxylase pathways, oxylipin biosynthesis, lipid hydroxylation, and steroid/hormone biosynthesis. This suggests a coherent functional theme of P450-mediated xenobiotic and lipid metabolism across diverse substrates.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019373","count":4},{"id":"GO:0042738","count":3},{"id":"GO:0097267","count":3},{"id":"GO:0031408","count":3},{"id":"GO:0042369","count":3}]},{"hash":"1669609591868192688","title":"RNA Processing and RNP Biogenesis","description":"The top terms are dominated by snoRNA-guided pseudouridine synthesis (rRNA/snRNA), snoRNP and box H/ACA assembly, ribosome biogenesis, and telomerase RNA stabilization/assembly. This points to a cluster of proteins involved in RNA modification and assembly of ribonucleoprotein complexes, with two development terms likely peripheral annotations. Overall, the theme is RNA processing and RNP biogenesis.","confidence":"High","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":2},{"id":"GO:0031069","count":2},{"id":"GO:0045600","count":2},{"id":"GO:0000454","count":1},{"id":"GO:1904874","count":1}]},{"hash":"1984685509396855041","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0031175","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0070306","count":4},{"id":"GO:0007338","count":4}]},{"hash":"721572215497133266","title":"Secondary metabolite biosynthesis and chemical detoxification","description":"This cluster shows strong signals for biosynthesis of secondary metabolites (anthocyanin-containing compounds; antibiotics) and a range of small-molecule catabolic and detoxification processes (fatty acid omega-oxidation, ethanol and sorbitol catabolism, furaldehyde metabolism, copper ion response, and response to antineoplastic agents). The shared theme appears to be enzymatic handling and processing of chemical compounds, including redox-related processes, rather than a single, narrow pathway. An outlier term (cell-matrix adhesion) is present but does not override the overall chemical metabolism/detox theme.","confidence":"Medium","size":12,"edges":6,"triangles":0,"max_degree":6,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0009718","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0007160","count":3},{"id":"GO:0097327","count":3}]},{"hash":"2201618706380438868","title":"Cholinergic Synaptic Signaling and Membrane Trafficking","description":"This cluster shows strong signals for cholinergic synaptic transmission and its regulation, together with processes of protein localization to the cell surface and endocytic trafficking between endosomes, plus receptor-mediated signaling. While a few terms relate to development or immune processes, the dominant pattern is membrane-associated neuronal signaling and trafficking.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032224","count":3},{"id":"GO:0022417","count":3},{"id":"GO:0007271","count":3},{"id":"GO:0034394","count":3},{"id":"GO:0007168","count":2}]},{"hash":"1165734227667802491","title":"Mammary Gland Development Signaling","description":"This set centers on mammary gland development and related signaling, including nipple morphogenesis, canonical Wnt signaling, and cell-cell signaling involved in mammary development, plus cell adhesion. While there are additional terms referencing broader connective tissue and immune processes, the mammary development theme is the most coherent thread among the terms.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001137","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0060427","count":3},{"id":"GO:0060658","count":3},{"id":"GO:1900042","count":2}]},{"hash":"215889760504066268","title":"Ubiquitin-Dependent Proteolysis in Mitosis","description":"The cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes, including SCF- and APC/C-mediated degradation, K11-linked ubiquitination, and core mitotic cell cycle and cell division terms. This points to a cohort of proteins involved in regulated proteolysis during mitosis and cell-cycle control, i.e., proteasome-targeted turnover critical for proliferation; a virus-defense association may reflect proteasome involvement in immune processing but is not primary. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0008283","count":4},{"id":"GO:0031146","count":4},{"id":"GO:0070979","count":3},{"id":"GO:0031145","count":3}]},{"hash":"1994919700071426949","title":"Vasodilation and smooth muscle signaling","description":"The GO terms point to vascular regulation and smooth muscle function, including relaxation and vasodilation (angiotensin-mediated vasodilation; relaxation of muscle; negative regulation of smooth muscle contraction), together with prostaglandin response and GPCR- and cAMP/PKA\u2013mediated signaling (ERK cascade regulation, hormone secretion). This suggests a coherent theme of controlling vascular tone and related hormonal signaling pathways.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090075","count":3},{"id":"GO:0043114","count":3},{"id":"GO:0071799","count":3},{"id":"GO:0045986","count":3},{"id":"GO:0046887","count":3}]},{"hash":"449385914035713494","title":"Methyltransferases and Methylation Pathways","description":"This cluster is dominated by GO terms for methylation across substrates and contexts, including histone H4-R3 methylation, N-terminal glycine methylation, peptidyl-arginine methylation, and rRNA guanine-N7 methylation, suggesting a core function as methyltransferases or involvement in methylation processes. Additional terms such as cobalamin and antibiotic biosynthesis indicate methylation-related steps in broader metabolic pathways. The collection of these methylation-related activities provides a cohesive functional theme, even if direct protein\u2013protein interactions are not captured in the current network.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090398","count":4},{"id":"GO:0043985","count":4},{"id":"GO:0018013","count":4},{"id":"GO:0016049","count":4},{"id":"GO:0046690","count":4}]},{"hash":"196049925238977652","title":"Ubiquitin-Mediated Immune Regulation","description":"This cluster is dominated by GO terms linking ubiquitination (ubiquitin-dependent protein catabolic process, K33-linked ubiquitination, regulation of protein ubiquitination) with immune-related processes (negative regulation of mast cell cytokine production, isotype switching to IgE, dendritic cell differentiation). The shared thread appears to be proteins involved in ubiquitin signaling that modulate immune responses, despite some annotation noise. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032764","count":1},{"id":"GO:0042787","count":1},{"id":"GO:2000312","count":1},{"id":"GO:1904431","count":1},{"id":"GO:0045497","count":1}]},{"hash":"1132322958780612407","title":"Neurodevelopment and differentiation","description":"The cluster is dominated by GO terms related to nervous system development, neurogenesis, olfactory lobe development, and myelination, plus related differentiation of neural crest derivatives such as melanocytes and myoblasts. Tubulin assembly and folding terms align with cytoskeletal remodeling in developing neurons. An outlier term on gamma-delta T cell activation does not detract from the overall neural-development focus.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0072277","count":2},{"id":"GO:0030318","count":2},{"id":"GO:0045663","count":2},{"id":"GO:0042552","count":2}]},{"hash":"1110926025250506189","title":"Embryonic development and morphogenesis","description":"The top GO terms cluster around developmental and morphogenetic processes across multiple tissues (endocrine development, EMT in heart cushion formation, cartilage morphogenesis, left-right patterning, placental/trophoblast differentiation, pancreatic cell development). Ubiquitination regulation and protein catabolic processes likely reflect regulatory layers supporting development. This provides a cohesive theme of embryogenesis and tissue morphogenesis for the cluster.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":4},{"id":"GO:0003198","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0031397","count":4},{"id":"GO:0060806","count":4}]},{"hash":"2146442335371749623","title":"Transmembrane Nutrient Transporters","description":"The cluster\u2019s top GO terms are dominated by membrane transport activities for nutrients (D-glucose, myo-inositol, pantothenate, biotin) and ion export, indicating these proteins likely function as transporters mediating uptake/export of nutrients. A few terms about cytoskeletal organization and development appear as outliers, but the central theme is transmembrane nutrient transport.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":1},{"id":"GO:0015798","count":1},{"id":"GO:0071436","count":1},{"id":"GO:0008292","count":1},{"id":"GO:0015878","count":1}]},{"hash":"1449769189135216867","title":"Ciliary and flagellar motility components","description":"The top GO terms cluster around inner dynein arm assembly, cilium movement, and flagellated sperm motility, all pointing to proteins involved in ciliogenesis and the mechanics of ciliary/flagellar movement; a few terms appear unrelated (e.g., stress granule assembly, antibiotic response) but do not override the dominant motility signal.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0032366","count":1},{"id":"GO:0009246","count":1},{"id":"GO:0036159","count":1},{"id":"GO:0003341","count":1}]},{"hash":"2025288215881352826","title":"Unknown","description":"There is no cohesive functional signal across the cluster: no edges or shared interactions, and only a single protein annotated to tRNA splicing. With no common GO terms or connectivity linking the proteins, there isn\u2019t a reliable theme to name the cluster beyond Unknown.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006388","count":1}]},{"hash":"451698009562292288","title":"Developmental and Immune Signaling","description":"The proteins are associated with heart development and growth control (hippo signaling), neuronal development and apoptosis, and immune regulation (B cell homeostasis, T cell proliferation), along with stress/hormone responses (glucocorticoid, hypoxia) and ubiquitin-dependent proteolysis. This combination suggests a broad signaling cluster that links development and organ growth with immune regulation and cellular stress responses, rather than a single narrow function.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0050774","count":2},{"id":"GO:0043525","count":2},{"id":"GO:0035329","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1979863048429005877","title":"Cytokinesis and Translation Machinery","description":"The cluster combines terms tied to cell division processes (division septum assembly, septin ring assembly/disassembly) with components of the translation apparatus (cytoplasmic translation, ribosomal small subunit biogenesis, tRNA modification). This suggests a theme where cell cycle progression and cytokinesis are coordinated with protein synthesis and ribosome biogenesis. Other terms like regulation of exocytosis may relate to vesicle trafficking during cytokinesis; salt-stress regulation appears less connected and may reflect incidental annotation noise.","confidence":"High","size":11,"edges":18,"triangles":10,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007049","count":5},{"id":"GO:0030154","count":5},{"id":"GO:0042274","count":5},{"id":"GO:0017157","count":5},{"id":"GO:0006400","count":5}]},{"hash":"1562173423696243462","title":"Embryonic organogenesis","description":"These proteins show GO terms spanning multiple organ development and morphogenesis (heart, eye, hindlimb, placenta, prostate, habenula) and related regulatory pathways (estrogen signaling, myoblast proliferation). The shared theme is embryonic development and organ formation across diverse tissues, rather than a single tissue-specific process, justifying the label Embryonic organogenesis.","confidence":"Medium","size":11,"edges":17,"triangles":9,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:2000288","count":6},{"id":"GO:0008584","count":6},{"id":"GO:0060527","count":6},{"id":"GO:0030520","count":6},{"id":"GO:0003148","count":6}]},{"hash":"1434943397269940793","title":"Neural differentiation and gliogenesis","description":"This cluster is enriched for neural development terms, including cerebellar granule cell differentiation, neuroblast fate commitment, and gliogenesis, along with dendritic spine development indicating maturation of neurons. Some chromatin remodeling and histone modification terms suggest regulatory mechanisms underpinning differentiation, but the central theme remains neural lineage specification.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":3},{"id":"GO:0001967","count":3},{"id":"GO:0060996","count":2},{"id":"GO:0006338","count":2},{"id":"GO:0006349","count":2}]},{"hash":"2140740274407247100","title":"Proteoglycan and glycosaminoglycan biosynthesis","description":"The top GO terms are dominated by proteoglycan and glycosaminoglycan biosynthetic processes (heparan sulfate, chondroitin sulfate, proteoglycan biosynthesis) and related nucleotide-sugar metabolism (UDP/GDP catabolic processes), suggesting the proteins work together in assembling extracellular matrix components. Some terms like cell wall organization and plant-specific glucuronoxylan biosynthesis appear, but the strongest shared function across the cluster is proteoglycan/glycosaminoglycan biosynthesis, with a few peripheral associations. ","confidence":"Medium","size":11,"edges":15,"triangles":4,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0015012","count":2},{"id":"GO:0030206","count":2},{"id":"GO:0015015","count":2},{"id":"GO:0046712","count":1},{"id":"GO:0060465","count":1}]},{"hash":"143223743505281126","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098789","count":2},{"id":"GO:0048574","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0048136","count":2},{"id":"GO:0031442","count":2}]},{"hash":"741356228801897592","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0051260","count":4},{"id":"GO:0050909","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0001403","count":3},{"id":"GO:2001235","count":3}]},{"hash":"2014358861862614518","title":"Unknown","description":"The listed GO terms are scattered across ubiquitination, immune regulation, and developmental processes with no clear single function tying the cluster together; the lack of shared pathway or interaction context suggests no cohesive theme.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032764","count":2},{"id":"GO:0042787","count":2},{"id":"GO:2000312","count":2},{"id":"GO:0035270","count":2},{"id":"GO:1904431","count":2}]},{"hash":"1377165266951176748","title":"Retroviral replication and genome integration","description":"The top GO terms cluster around retroviral lifecycle steps: RNA-templated DNA biosynthesis (reverse transcription), DNA integration into the host genome, and establishment of proviral latency, plus viral entry into the host nucleus. Some terms reflect general DNA processes or housekeeping activities, but the dominant pattern points to retroviral replication and genome integration.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006784","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0043137","count":2},{"id":"GO:0006278","count":2}]},{"hash":"96068190715960319","title":"Cell signaling, adhesion, and cytoskeletal regulation","description":"The top GO terms revolve around integrin signaling, cell adhesion mediated by integrins, stress fiber/cytoskeletal regulation, and cell polarity establishment, with supporting signaling pathways and signal complex assembly. While there are a few outlier terms (DNA replication, CpG methylation) they do not override the dominant theme of signaling linked to adhesion and cytoskeletal dynamics. This suggests a cohesive cluster focused on how cells communicate and attach to their surroundings via the cytoskeleton.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060396","count":2},{"id":"GO:0051492","count":2},{"id":"GO:0033628","count":2},{"id":"GO:0050853","count":2},{"id":"GO:2000114","count":2}]},{"hash":"348786421299908736","title":"Developmental cell adhesion and migration","description":"This cluster centers on GO terms related to development and cell movement, including focal adhesion assembly and neuron migration, plus proliferation/regulation across tissues (Sertoli cells, osteoblasts, B cells). The recurring theme is developmental processes involving cell adhesion and cellular migration, with supporting notes on survival and proliferation signals, suggesting a cohesive role in developmental growth and tissue organization rather than a single pathway. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048041","count":2},{"id":"GO:0060011","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0009791","count":2},{"id":"GO:0001764","count":2}]},{"hash":"1489484787961077779","title":"Mitochondrial lipid metabolism and membrane organization","description":"Top GO terms center on mitochondrial function (inner mitochondrial membrane organization, cardiolipin metabolism) and lipid regulation (SREBP signaling), suggesting a cluster of proteins involved in mitochondrial lipid homeostasis and membrane dynamics; a few immune/development terms appear but likely reflect broader regulatory roles or annotation overlap.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0032933","count":9},{"id":"GO:0072249","count":9},{"id":"GO:0052547","count":9},{"id":"GO:1900210","count":9},{"id":"GO:1903905","count":9}]},{"hash":"1443561070492650055","title":"Endocytosis and actin remodeling","description":"The cluster shows enrichment for endocytosis-related GO terms (including both endocytosis and its negative regulation) alongside actin cytoskeleton and adhesion processes (actin cortical patch assembly, podosome assembly, substrate adhesion-dependent cell spreading) and ephrin signaling. This points to proteins involved in membrane trafficking and actin-driven remodeling, compatible with endocytic/phagocytic activity and cytoskeletal dynamics.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045806","count":5},{"id":"GO:0006897","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0048013","count":3},{"id":"GO:0071803","count":3}]},{"hash":"771375224504152074","title":"Immune signaling and cytoskeletal regulation via ubiquitination","description":"The terms are dominated by innate and adaptive immune responses and NF-kappaB regulation, pointing to immune signaling, with additional terms tied to cytoskeletal remodeling through actin/Rho pathways and ubiquitination (including myoblast fusion-related processes). This suggests a cluster where immune signaling is tightly linked to cytoskeletal dynamics and protein turnover.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0046007","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0002250","count":3},{"id":"GO:0007520","count":3}]},{"hash":"2180648869066357928","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by GO terms for ribosome biogenesis, cytoplasmic translation, translation initiation, and ribosomal subunit export from the nucleus, indicating a core role in ribosome assembly and protein synthesis. Additional terms related to cell cycle and cell division may reflect coordination with growth, while a single SREBP signaling term appears ancillary.","confidence":"High","size":11,"edges":8,"triangles":1,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0000747","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0002181","count":2}]},{"hash":"278673401928841236","title":"Tissue development and morphogenesis","description":"The proteins map to diverse developmental and morphogenetic roles across tissues: sarcomere organization and smooth muscle proliferation (muscle-related processes), motor neuron axon guidance and synapse assembly (neural wiring), retina morphogenesis, skeletal system development, and podocyte development, plus cell-cell adhesion and interneuron migration cues. This suggests a common theme of tissue development and morphogenesis rather than a single functional pathway.  ","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045214","count":8},{"id":"GO:0008045","count":8},{"id":"GO:0051965","count":8},{"id":"GO:0007275","count":8},{"id":"GO:0021836","count":8}]},{"hash":"984777314173128438","title":"ECM Assembly and Tissue Remodeling","description":"This cluster centers on extracellular matrix components and organization (collagen fibril organization, elastic fiber assembly) and includes regulation of cell-substrate adhesion, pointing to connective tissue remodeling. Additional GO terms about inflammatory signaling (interleukin-1, leptin) and apoptotic pathway regulation suggest associated tissue homeostasis processes. A few insect-specific terms (cuticle development) hint species-specific contexts, but the core theme appears to be ECM assembly/remodeling.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0035641","count":1},{"id":"GO:0072012","count":1},{"id":"GO:0010812","count":1},{"id":"GO:0043654","count":1}]},{"hash":"1558838867987960070","title":"Steroid Hormone Signaling and Prostate Development","description":"This cluster is dominated by GO terms tied to steroid hormone signaling and nuclear receptor activity: steroid hormone receptor complex assembly, positive regulation of nuclear receptor-mediated glucocorticoid signaling, male sex differentiation, and prostate gland development. These terms point to a common theme of hormone-driven transcriptional regulation, including glucocorticoid pathways. The additional terms\u2014cellular response to type I interferon and ubiquitination\u2014likely reflect cross-talk between hormone signaling and immune or protein turnover processes, while glucocorticoids also influence gluconeogenesis. A few terms (cytokinin signaling, morphine response) may reflect annotation breadth or cross-kingdom signaling noise, but do not override the central steroid receptor signal.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0071357","count":6},{"id":"GO:0006463","count":6},{"id":"GO:0046661","count":6},{"id":"GO:0030850","count":6},{"id":"GO:2000324","count":5}]},{"hash":"303361658576091951","title":"RNA metabolism and ribosome biogenesis","description":"The cluster centers on RNA processing and maturation (splicing, rRNA processing, histone mRNA metabolism, mRNA decapping) and ribosome biogenesis, with additional links to transcription termination and nuclear import, all pointing to a coordinated gene-expression machinery. Some chromatin-related term hints at broader genomic regulation, but the dominant signal is RNA metabolism and ribosome assembly.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0045292","count":4},{"id":"GO:0042254","count":4},{"id":"GO:1990141","count":3},{"id":"GO:0070317","count":3},{"id":"GO:0000290","count":3}]},{"hash":"1742323217658095670","title":"Microtubule Dynamics and Adherens Junctions","description":"This cluster centers on microtubule remodeling (plus- and minus-end sliding, depolymerization, and regulation of microtubule-based processes) and maintenance of adherens junctions (zonula adherens). The presence of epidermal stem cell homeostasis and neural tissue organization terms suggests a broader role in tissue architecture and development, where cytoskeletal changes coordinate cell adhesion and growth responses.","confidence":"High","size":11,"edges":38,"triangles":84,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0001560","count":5},{"id":"GO:0031535","count":5},{"id":"GO:0045218","count":5},{"id":"GO:0036334","count":5},{"id":"GO:0060404","count":5}]},{"hash":"662806851134394326","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0010610","count":10},{"id":"GO:0006402","count":8},{"id":"GO:0090503","count":8},{"id":"GO:0098908","count":7},{"id":"GO:2000627","count":7}]},{"hash":"1921353429749958062","title":"Protein modification and localization","description":"The terms cluster around post-translational modifications (peptidyl-tyrosine sulfation; serine acetylation), ubiquitination (K11-linked), and processes regulating protein turnover and trafficking (APC-dependent catabolic process; localization to photoreceptor outer segments; cilium assembly). Signaling pathways (glucocorticoid receptor signaling; cytokinin signaling) and physiological readouts (blood pressure regulation) also connect to modulating protein function and localization. Taken together, the common thread is regulation of protein function through modifications and precise subcellular localization, justifying a label focused on protein modification and localization.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006478","count":2},{"id":"GO:2000324","count":2},{"id":"GO:1902391","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0003085","count":2}]},{"hash":"930232234015103144","title":"Microbial lipid and cofactor biosynthesis","description":"The top GO terms are dominated by metabolic biosynthesis related to lipids and cofactors: long-chain and very long-chain fatty acid metabolism, medium-chain fatty-acyl-CoA metabolism, bile acid metabolism, menaquinone biosynthesis, acetyl-CoA biosynthesis, and siderophore biosynthesis. This suggests a coherent theme around microbial metabolism and biosynthetic pathways, even though a few regulatory terms (Wnt signaling, seed germination) appear less consistently. Overall, the cluster seems to group proteins involved in lipid and cofactor-related biosynthetic processes in microbes.","confidence":"Medium","size":11,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009234","count":5},{"id":"GO:0010124","count":5},{"id":"GO:0090263","count":4},{"id":"GO:0000038","count":4},{"id":"GO:0019427","count":4}]},{"hash":"1156667685283177898","title":"Dopaminergic signaling and neuronal development","description":"The top GO terms strongly point to nervous system biology, highlighting neuron projection extension and positive regulation of dopamine metabolism, which together suggest dopaminergic signaling and neural development. Endocrine links are also indicated by pituitary gland development and corticosterone response, supporting a neuroendocrine context. Some terms (e.g., stress and redox-related responses) are less central, but the neuronal/dopaminergic signals appear to dominate the cluster theme.","confidence":"Medium","size":11,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0071320","count":4},{"id":"GO:0009409","count":4},{"id":"GO:0010725","count":4},{"id":"GO:0060992","count":4}]},{"hash":"268387288841098892","title":"Embryonic neural and organ development","description":"The GO terms cluster around embryogenesis, with multiple entries on neural development (neuron migration, brain/midbrain/spinal cord development) and broad organ morphogenesis (heart, thyroid gland, organ induction, cranial skeleton morphogenesis). This points to a cohesive theme of embryonic development affecting neural and other organ systems, justifying the label.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001764","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0048701","count":4},{"id":"GO:0003350","count":4}]},{"hash":"1804920313769886443","title":"Neurodevelopment and Muscle Formation","description":"This cluster centers on developmental processes spanning nervous system formation (neuron differentiation, migration, axon guidance, brain region patterning) and muscle development (myoblast proliferation, muscle organ formation), with additional terms reflecting broader anterior-posterior patterning and organ-specific development (e.g., AV node, thyroid). The shared theme appears to be coordinated programs guiding neurogenesis alongside musculature development.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021527","count":11},{"id":"GO:0030878","count":11},{"id":"GO:0021978","count":11},{"id":"GO:0009952","count":11},{"id":"GO:2000288","count":11}]},{"hash":"281034304043244735","title":"GTPase signaling and actin remodeling","description":"Top GO terms indicate a unifying theme of small GTPase\u2013driven signal transduction coupled to actin cytoskeleton organization and cell motility, including neuronal migration-related leading-process extension. While growth factor receptor signaling (insulin/IGF) and B cell receptor signaling appear, the core signal transduction driving cytoskeletal dynamics and movement best explains the cluster.","confidence":"High","size":11,"edges":15,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0043314","count":2},{"id":"GO:0060313","count":2},{"id":"GO:0007264","count":2},{"id":"GO:0021816","count":2},{"id":"GO:0030036","count":2}]},{"hash":"112320214055482928","title":"Unknown","description":"This set combines GO terms across telomere maintenance, epithelial polarity, proteasome assembly, stress response, chemokine production, Wnt signaling, cardiac electrophysiology, foam cell differentiation, and NOD2 signaling. There is no single dominant function or pathway that ties all terms together, suggesting a mixed collection rather than a cohesive biological theme.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904357","count":3},{"id":"GO:0090162","count":3},{"id":"GO:0070682","count":3},{"id":"GO:0009409","count":3},{"id":"GO:0071651","count":3}]},{"hash":"2181696629507984718","title":"Unknown","description":"The GO terms span several distinct biological themes (heart development, enamel mineralization, fat cell differentiation, germ cell death) but also include immune-related regulation and membrane/channel processes (negative regulation of T cell proliferation, foam cell differentiation, voltage-gated K+ channel clustering) and symbiont entry. The lack of a single coherent function or pathway linking these terms means there isn\u2019t a robust, representative label to assign to the cluster. ","confidence":"","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0046718","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0035234","count":3},{"id":"GO:0046007","count":3}]},{"hash":"481985921992604412","title":"Neural development and GABAergic signaling","description":"Most represented terms point to neural development and GABAergic synaptic transmission, suggesting a cluster of proteins involved in neuronal differentiation and inhibitory signaling; membrane-related processes (transmembrane transport, phospholipid homeostasis) fit this theme, while unrelated terms like keratinization and ossification may reflect multifunctional proteins.","confidence":"Medium","size":11,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055091","count":4},{"id":"GO:0010628","count":4},{"id":"GO:0031424","count":3},{"id":"GO:0043525","count":3},{"id":"GO:0071806","count":3}]},{"hash":"516551258653717234","title":"Organ Development and Immune Activation","description":"This cluster combines organogenesis-related terms (kidney development, angiogenesis, neuron projection development, olfactory lobe development) with immune activation terms (innate immune response, NK cell activation, gamma-delta T cell activation), indicating a theme of developmental processes with concurrent immune signaling. Some terms (sporulation, cell division) are less cohesive, so the overall theme is moderate in cohesion.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0030101","count":2}]},{"hash":"1556906540087376464","title":"Glycosylation and proteoglycan biosynthesis in development","description":"This cluster is driven by glycan-related biosynthesis terms, including keratan sulfate proteoglycan and glycosphingolipid biosynthesis, and is linked to developmental processes such as mammary gland involution, secondary sexual characteristics, and wound-associated angiogenesis. The common thread appears to be carbohydrate modification and extracellular matrix-related development.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0007339","count":2},{"id":"GO:0018146","count":2},{"id":"GO:0048147","count":2},{"id":"GO:0005989","count":2}]},{"hash":"510339110291633381","title":"Neural signaling and olfactory learning with ion transport","description":"This cluster is enriched for neural and sensory-related functions: olfactory learning, social behavior, serotonin metabolism, locomotion, and development of the lateral line, plus multiple ion transport processes (sodium, potassium, calcium). Together these terms suggest a coherent theme of neural signaling driving sensory perception and behavior, mediated by ion channel activity. Therefore the label reflects both sensory/olfactory aspects and ion transport mechanisms.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008355","count":3},{"id":"GO:0042428","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0010157","count":2},{"id":"GO:0035725","count":2}]},{"hash":"131641996156907117","title":"Ciliary motility and microtubule-based transport","description":"The proteins are linked to ciliary functions (inner dynein arm assembly, cilium movement, flagellated sperm motility, intraciliary transport) and microtubule-based transport processes (minus-end- directed and anterograde vesicle transport, spindle localization), with developmental terms reflecting ciliary signaling roles in left-right patterning. This points to a cohesive theme of ciliary machinery and intracellular transport rather than unrelated processes.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036159","count":1},{"id":"GO:0003341","count":1},{"id":"GO:0030317","count":1},{"id":"GO:0034063","count":1},{"id":"GO:0021670","count":1}]},{"hash":"1381584563705569913","title":"Neuronal signaling and synaptic plasticity","description":"The top GO terms cluster around neural signaling (GABA pathway, excitatory postsynaptic potential), ion transport essential for neuronal excitability (sodium/potassium transmembrane transport), and synaptic plasticity/learning processes (long-term potentiation, conditioned taste aversion, locomotory and sensory behaviors). These collectively point to functions in neural communication, synaptic regulation, and experience-dependent plasticity, with muscle-related signals likely reflecting neuromuscular or motor aspects. Overall, the theme is neural signaling and synaptic plasticity.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007214","count":10},{"id":"GO:0035725","count":10},{"id":"GO:0071805","count":10},{"id":"GO:0007626","count":10},{"id":"GO:0001661","count":10}]},{"hash":"1537651933517720754","title":"Developmental Morphogenesis","description":"The top GO terms point to a broad theme of development and organ/tissue morphogenesis across multiple organs and species (plant stomatal development, floor plate and hindbrain morphogenesis, oculomotor nerve development, mesenchyme development, sinus venosus morphogenesis, and neural development). This suggests the cluster groups proteins involved in general developmental programs rather than a single specific pathway, making Developmental Morphogenesis a concise, representative label.","confidence":"Medium","size":10,"edges":15,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0010374","count":1},{"id":"GO:0035481","count":1},{"id":"GO:0042981","count":1},{"id":"GO:0033504","count":1},{"id":"GO:0003236","count":1}]},{"hash":"1257534757679813927","title":"Larval cuticle development","description":"The cluster's top GO term is larval chitin-based cuticle development (GO:0008363), observed in 3 proteins, which points to a possible insect developmental theme. The remaining terms are diverse (ubiquitination, gluconeogenesis regulation, morphine response, cell division, photoreceptor organization, protein complex oligomerization, and some obsolete terms), suggesting a heterogeneous mix of functions rather than a single cohesive pathway. Thus, the label captures the strongest signal but may not fully reflect all members' roles.","confidence":"Low","size":10,"edges":39,"triangles":87,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:1902391","count":1},{"id":"GO:0070979","count":1},{"id":"GO:0090526","count":1},{"id":"GO:0043278","count":1}]},{"hash":"142041631551460124","title":"BMP/TGF-\u03b2 Signaling Modulation","description":"This cluster centers on terms involving BMP signaling regulation and TGF-\u03b2\u2013related responses (e.g., negative regulation of BMP signaling, cellular response to TGF-\u03b2), indicating a theme of developmental growth-factor signaling modulation. Some terms are generic or obsolete, or span other processes, but the BMP/TGF-\u03b2 linkage provides the most coherent unifying function.","confidence":"Medium","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0019878","count":2},{"id":"GO:0006470","count":2},{"id":"GO:0042347","count":2},{"id":"GO:0000173","count":2}]},{"hash":"2135010016886535365","title":"Chromosome maintenance and DNA replication","description":"Top GO terms are heavily centered on nuclear processes: DNA-templated transcription, DNA replication, CENP-A\u2013containing chromatin assembly, and import into the nucleus, along with cell division and microtubule severing. This points to chromosome maintenance and cell-cycle machinery as the cluster's shared function. Some terms (ER to Golgi transport, ERAD) reflect general protein handling and are less defining for this cluster.","confidence":"High","size":10,"edges":10,"triangles":2,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0061641","count":2}]},{"hash":"1289703152500259744","title":"Actin Cytoskeleton and Sarcomere Organization","description":"The top GO terms cluster around actin-related processes (actin filament bundle assembly, sarcomere organization, platelet aggregation), pointing to cytoskeletal dynamics and muscle/contractile structures as the core function. Some terms appear anomalous (retinol/retinal metabolism, ascospore wall assembly, behavioral terms), but the strongest signals are clearly actin/muscle-associated, supporting a cytoskeletal theme.","confidence":"High","size":10,"edges":24,"triangles":28,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0070527","count":4},{"id":"GO:0051017","count":4},{"id":"GO:0042572","count":3},{"id":"GO:0042574","count":3},{"id":"GO:0030476","count":3}]},{"hash":"1806708832754313839","title":"DNA repair and mitotic control","description":"The strongest signals come from nucleotide-excision repair, mitotic transitions (G2/M, exit from mitosis), chromosome segregation, and ubiquitin-proteasome\u2013mediated proteolysis (K11-linked ubiquitination and SCF). These collectively point to genome maintenance and cell-cycle regulation, with some immune signaling terms likely incidental. Confidence: Medium","confidence":"","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0070911","count":10},{"id":"GO:0000086","count":10},{"id":"GO:0031146","count":10},{"id":"GO:0016032","count":10},{"id":"GO:0010458","count":10}]},{"hash":"2221189589174161156","title":"CD8+ T cell activation and cytotoxic signaling","description":"Top GO terms indicate strong enrichment for T cell receptor signaling, CD8+ T cell proliferation, and granzyme B production, pointing to adaptive immune activation and cytotoxic responses as the core function; a few nonimmune terms may reflect broader signaling roles but do not redefine the cluster.","confidence":"High","size":10,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0038095","count":3},{"id":"GO:1900271","count":3},{"id":"GO:0022011","count":3},{"id":"GO:1903244","count":3}]},{"hash":"1272401683572998745","title":"Transcription Regulation and RNA Processing","description":"Label reflects a cluster centered on gene expression regulation at both transcriptional and post-transcriptional levels, evidenced by terms for DNA-templated transcription, transcription termination/antitermination, and pre-miRNA processing plus miRNA decay and mRNA stabilization.","confidence":"Medium","size":10,"edges":38,"triangles":71,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1901724","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0070934","count":2},{"id":"GO:1902219","count":2},{"id":"GO:0010587","count":2}]},{"hash":"2225592273233614021","title":"Neural signaling and stress-response regulation","description":"This cluster shows several GO terms tied to neuronal communication (excitatory postsynaptic potential), neuronal development regulation (negative regulation of dendrite development, negative regulation of neuron apoptotic process) and calcium signaling (calcium ion import). It also includes stress-related terms (response to isolation stress, response to antibiotic) and broader cell-context processes (epithelial polarity, cell cycle), suggesting a theme around neural signaling intertwined with cellular stress responses and regulation of development. Confidence: Medium","confidence":"","size":10,"edges":9,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035900","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0098703","count":2},{"id":"GO:0060079","count":2}]},{"hash":"2106951316959361470","title":"Neuronal signaling and circadian regulation","description":"The leading GO terms cluster around neural communication and synaptic changes (GABA signaling, long-term potentiation, postsynaptic membrane organization) and circadian-related regulation (sleep/wake cycle, ovulation rhythm), suggesting a theme of neuronal signaling intertwined with rhythmic control. Although ER-Golgi transport and acrosome reaction are present, they appear less central to the core neuronal/synaptic rhythm theme.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0007214","count":2},{"id":"GO:0048630","count":2},{"id":"GO:1902004","count":2},{"id":"GO:1900273","count":2}]},{"hash":"1061403840361467088","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071374","count":1},{"id":"GO:0098869","count":1},{"id":"GO:1903026","count":1},{"id":"GO:0043388","count":1},{"id":"GO:1901621","count":1}]},{"hash":"1555405652336514829","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0036265","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0000463","count":4}]},{"hash":"1152041542614714093","title":"RNA Processing and Translation Regulation","description":"The cluster shows strong signals for post-transcriptional RNA processing (mRNA modification, splicing via the spliceosome, polyadenylation) and regulation of translation initiation (preinitiation complex formation, regulation of translational initiation), plus ncRNA-mediated gene silencing. Together these terms point to a cohesive module of proteins coordinating RNA processing and control of protein synthesis.","confidence":"High","size":10,"edges":42,"triangles":98,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0075525","count":2},{"id":"GO:1901407","count":2},{"id":"GO:0006378","count":2},{"id":"GO:1902625","count":2},{"id":"GO:0016556","count":2}]},{"hash":"388832969665134951","title":"Translation Initiation and Reinitiation","description":"The cluster is dominated by translation-related terms: formation of the translation preinitiation complex, IRES-dependent initiation, and translation reinitiation, suggesting roles in initiating protein synthesis. TORC1 signaling also appears, linking to translational control; other terms like mRNA modification and cilium assembly are present but likely secondary.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0038202","count":2},{"id":"GO:0060271","count":2}]},{"hash":"2296112754045538455","title":"Multi-tissue organogenesis","description":"The top GO terms indicate development and differentiation across many tissues (neuronal forebrain commitment, gonads, pituitary, uterus, inner ear, cartilage, pharyngeal system, etc.), suggesting the cluster reflects broad organogenesis and tissue development programs rather than a single pathway.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021902","count":4},{"id":"GO:0008584","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0003309","count":4},{"id":"GO:0021983","count":4}]},{"hash":"2111496147632775730","title":"Cytochrome P450\u2013driven xenobiotic and lipid metabolism","description":"This cluster is enriched for P450-related metabolic processes: omega-hydroxylase P450 activity, lipid hydroxylation, oxylipin biosynthesis, and various xenobiotic and steroid-related catabolic/metabolic pathways (xenobiotics, vitamin D, cortisol, brassinosteroids). The common thread is cytochrome P450\u2013mediated processing of xenobiotics, lipids, and hormones, with mammary development likely reflecting hormonal regulation context; thus, a P450-centered metabolism label is appropriate.","confidence":"Medium","size":10,"edges":15,"triangles":5,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0030879","count":6},{"id":"GO:0042738","count":5},{"id":"GO:0097267","count":5},{"id":"GO:0031408","count":5},{"id":"GO:0042369","count":5}]},{"hash":"2281608535781960907","title":"Mitochondrial Transport and Membrane Dynamics","description":"The cluster is clearly centered on mitochondrial processes, with GO terms detailing transmembrane transport of nucleotides and cofactors, phosphate, and other metabolites, plus regulation of membrane potential, the malate-aspartate shuttle, mitochondrial membrane fission, and links to adaptive thermogenesis, indicating a cohesive module of mitochondrial transport, metabolism, and dynamics.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000066","count":8},{"id":"GO:0034198","count":8},{"id":"GO:0051881","count":8},{"id":"GO:0035435","count":8},{"id":"GO:0030302","count":8}]},{"hash":"678253117632590535","title":"Unknown","description":"The GO terms are highly heterogeneous: multiple transport-related terms (antimonite, arsenite, sodium-dependent organic anion, pyruvate transport) alongside endothelial proliferation, development, DNA transposition and glucose response. No single functional theme emerges that ties all proteins together, and many terms are low-frequency annotations; a unified label is not clearly justifiable.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015699","count":1},{"id":"GO:0043251","count":1},{"id":"GO:0015700","count":1},{"id":"GO:0006849","count":1},{"id":"GO:0001935","count":1}]},{"hash":"2305224138774495099","title":"Unknown","description":"There are no GO terms or connections to infer a shared function; with 0 edges/triangles and an empty Top Terms list, the proteins do not show a common biological theme in this cluster.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1174930042513998542","title":"Vertebrate organ and sensory development","description":"The gene set is enriched for GO terms spanning development of multiple vertebrate organs and sensory structures, including heart, thyroid gland, cerebellum and inner ear, as well as visual perception and growth hormone signaling, suggesting a cohesive theme of embryonic organogenesis and sensory system formation. The single outlier term (antibiotic biosynthetic process) is likely annotation noise rather than a true functional signal.","confidence":"High","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0048701","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0017000","count":4}]},{"hash":"343727018257968013","title":"Unknown","description":"The terms span neurodevelopment (ventricular zone neuroblast division, neuron migration), morphogenesis (branching in salivary gland), muscle structure (sarcomere organization), epithelium maintenance, and immune activation (gamma-delta T cell activation, granzyme B production) with signaling (ERK cascade). There is no clear single function tying these together, so a specific label isn\u2019t evident.","confidence":"","size":10,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045163","count":1},{"id":"GO:0045214","count":1},{"id":"GO:0030277","count":1},{"id":"GO:0071663","count":1},{"id":"GO:0021847","count":1}]},{"hash":"537526771248936676","title":"Unknown","description":"The GO terms are too heterogeneous (lipid/sterol and mitochondrial metabolism alongside neural differentiation and other unrelated processes), with no single clear common function uniting the cluster. This suggests either a mixed or noisy set of annotations, so a precise, intuitive label cannot be reliably assigned.","confidence":"","size":10,"edges":14,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006636","count":3},{"id":"GO:0001949","count":3},{"id":"GO:0000001","count":3},{"id":"GO:0006809","count":3},{"id":"GO:0042128","count":3}]},{"hash":"919490387083011131","title":"Antioxidant Detoxification and Metabolism","description":"This cluster is dominated by GO terms for detoxifying reactive oxygen species and metabolizing antioxidants (cellular oxidant detoxification, glutathione metabolism, L-ascorbic acid metabolism) along with toxin catabolic processes and prostaglandin biosynthesis, all pointing to a coordinated oxidative stress response and related metabolic pathways. The presence of nucleotide-excision repair fits with cellular responses to DNA damage under oxidative stress, reinforcing the detox/metabolism theme.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":7},{"id":"GO:0006289","count":7},{"id":"GO:0060316","count":7},{"id":"GO:0042594","count":7},{"id":"GO:0014810","count":7}]},{"hash":"1247813968009555292","title":"Inflammation and immune-vascular signaling","description":"The proteins cluster around immune and inflammatory processes (adaptive immune response, antigen processing and presentation via MHC I, leukotriene biosynthesis) as well as vascular-related remodeling (positive regulation of angiogenesis, angiotensin maturation). Ectodomain proteolysis suggests modulation of signaling via membrane protein shedding, which ties into both immune signaling and tissue remodeling. The combination indicates a theme of inflammation and immune activity with concurrent vascular signaling and host interaction, including potential roles in symbiont entry. ","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0007267","count":5},{"id":"GO:0045766","count":5},{"id":"GO:0006509","count":5},{"id":"GO:0030154","count":5},{"id":"GO:0002005","count":5}]},{"hash":"988319378799316636","title":"Cell cycle control and ciliogenesis","description":"The cluster shows a strong representation of cell cycle-related processes (cell division; anaphase-promoting complex-dependent catabolic process; K11-linked ubiquitination) and non-motile cilium assembly, which together point to coordinated regulation of cell division and ciliogenesis. There are additional signals of hormone signaling and male development (steroid hormone receptor complex assembly; male sex differentiation; prostate gland development) that may reflect context-specific regulation, alongside a weaker interferon response signal. Overall, the dominant theme appears to be cell cycle control with ciliogenesis as a key connected process.","confidence":"Medium","size":10,"edges":8,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071357","count":5},{"id":"GO:0006463","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0046661","count":5},{"id":"GO:0030850","count":5}]},{"hash":"1830359243798913737","title":"Neural development and synaptic connectivity","description":"The top GO terms cluster around neural development and synaptic function\u2014regulation of synapse assembly, neuron migration, nerve impulse transmission, and neuroblast division\u2014with supporting roles from cell adhesion and ERK signaling. While a couple terms touch other processes (sarcomere organization, symbiont entry), the dominant theme is neuronal development and synaptic connectivity.","confidence":"High","size":10,"edges":8,"triangles":2,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051963","count":8},{"id":"GO:0007156","count":8},{"id":"GO:0046718","count":8},{"id":"GO:0007157","count":8},{"id":"GO:0045163","count":7}]},{"hash":"1669484914060715325","title":"Sterol and lipid biosynthesis","description":"Based on the GO terms, the dominant theme is lipid and sterol metabolism, including cholesterol and ergosterol biosynthesis, sterol oxidation steps, and related fatty acid/ether lipid pathways. A few terms are tissue-specific (B cell chemotaxis, sebaceous gland differentiation, CNS myelin maintenance), but the common thread across the cluster is sterol and lipid biosynthesis and metabolism.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0080065","count":3},{"id":"GO:0035754","count":3},{"id":"GO:0033490","count":3},{"id":"GO:0001949","count":3},{"id":"GO:0006675","count":3}]},{"hash":"1132186816699025218","title":"Proteostasis and Intracellular Transport Regulation","description":"The cluster's top GO terms point to protein turnover control (positive regulation of endopeptidase activity and deubiquitination) and intracellular trafficking (anterograde axonal transport and negative regulation of intracellular transport). These shared themes suggest a core function in proteostasis linked to transport processes, with other terms reflecting stress or tissue contexts rather than a single unified process. Confidence: Medium","confidence":"","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0010950","count":4},{"id":"GO:0016579","count":4},{"id":"GO:0032355","count":3},{"id":"GO:0099641","count":3},{"id":"GO:0032387","count":3}]},{"hash":"1412699190871801760","title":"Proteoglycan biosynthesis and sulfation","description":"The cluster is characterized by multiple GO terms related to biosynthesis of proteoglycans and their glycosaminoglycan chains (heparan, keratan, chondroitin/obsolete), along with sulfation-related processes (protein sulfation, sulfate assimilation, N-acetylglucosamine metabolism). This strongly points to a coherent theme of proteoglycan assembly and modification, with a few additional terms hinting at broader vascular or adipogenic contexts that are less central to the core function.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0015012","count":5},{"id":"GO:0002002","count":5},{"id":"GO:0030210","count":5},{"id":"GO:0018146","count":5},{"id":"GO:0045600","count":5}]},{"hash":"111967182365438304","title":"Calcium signaling and muscle activity","description":"Most terms point to calcium signaling and calcium-mediated contraction or neural activity: calcium transport, presynaptic calcium regulation, calcium release into cytosol, calcium channel regulation, and cardiac electrical coupling, with myosin II filament assembly supporting muscle contraction. A couple of outlier developmental terms may reflect annotation noise. Therefore, label reflects a Calcium signaling and muscle activity theme.","confidence":"High","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0031036","count":1},{"id":"GO:0042554","count":1},{"id":"GO:0099509","count":1},{"id":"GO:0051281","count":1}]},{"hash":"756809969419180046","title":"P450-mediated xenobiotic and hormone metabolism","description":"The top GO terms converge on cytochrome P450\u2013related processes: omega-hydroxylase P450 pathway, xenobiotic catabolic/dioxin metabolism, oxylipin biosynthesis, and various hormone/vitamin-related biosynthetic/catabolic steps (vitamin D, cortisol, brassinosteroids). This pattern suggests a functional cluster of P450-driven metabolism of xenobiotics and endogenous hormones/lipid signals.","confidence":"High","size":9,"edges":6,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":4},{"id":"GO:0006809","count":3},{"id":"GO:0042738","count":3},{"id":"GO:0097267","count":3},{"id":"GO:0031408","count":3}]},{"hash":"808625583267779844","title":"Amino Acid Catabolism and Hematopoietic Differentiation","description":"The top GO terms include valine and leucine catabolic processes, alongside granulocyte and erythrocyte differentiation, pointing to a mix of metabolic processing and blood cell lineage differentiation. While other terms reflect stress responses and biosynthesis, the strongest signals align with amino acid catabolism and hematopoietic differentiation, justifying this combined label.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0006574","count":4},{"id":"GO:0030851","count":4},{"id":"GO:0006552","count":4},{"id":"GO:0045648","count":4}]},{"hash":"795335847232981818","title":"DNA replication and cell cycle machinery","description":"The top terms are centered on DNA replication, cell cycle, and cell division, indicating a core role in proliferation and replication. Embryonic organ development supports a developmental/proliferative context, while translation initiation regulation, proteasomal degradation, and transcription regulation reflect broader gene-expression control linked to cell-cycle progression.","confidence":"High","size":9,"edges":9,"triangles":2,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0008283","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0048568","count":3},{"id":"GO:0007049","count":3}]},{"hash":"1215109794639934047","title":"Retroviral entry and proviral latency","description":"Dominant terms center on viral genome integration and proviral latency: DNA integration, DNA replication, viral entry into the nucleus, and establishment of integrated proviral latency. Together these point to retroviral-like infection and maintenance of provirus. A few terms about host apoptosis and symbiont entry are peripheral noise and do not override the main signal. Therefore the label Retroviral entry and proviral latency is representative of the cluster.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0039651","count":2}]},{"hash":"32090728660707586","title":"Unknown","description":"The top GO terms are scattered across diverse biology (larval cuticle development, cell shape regulation, calcium signaling and synaptic plasticity, calcineurin-NFAT signaling, protein dephosphorylation, fungal mating, and cardiac hypertrophy), with no connections among the proteins (no edges, no triangles). This lack of a cohesive functional theme makes it inappropriate to assign a specific, representative label beyond Unknown.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0008360","count":1},{"id":"GO:0099509","count":1},{"id":"GO:0032516","count":1},{"id":"GO:0060291","count":1}]},{"hash":"694378007689376239","title":"Unknown","description":"The top terms cover translation initiation, actin assembly, endocytosis, apoptosis, mRNA decay, viral transcription regulation, monocyte differentiation, MAPK signaling, and sugar response. This broad mix provides no single coherent function tying the proteins together, and with no edges, the cluster appears functionally diverse rather than a unified process.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0000147","count":3},{"id":"GO:0006897","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0098789","count":2}]},{"hash":"597535507619425499","title":"Telomere maintenance regulation and telomeric localization","description":"The top GO terms emphasize regulation of telomere maintenance, telomere lengthening, telomerase activity, telomere capping, and localization to telomeric regions, pointing to proteins involved in preserving chromosome ends and controlling telomere dynamics. Some terms (spindle assembly, Wnt signaling) are broader cellular processes, but the core signal centers on telomere-associated regulation and chromosomal end protection.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904357","count":3},{"id":"GO:0051225","count":3},{"id":"GO:0016055","count":3},{"id":"GO:1904743","count":3},{"id":"GO:0032212","count":3}]},{"hash":"2298662597978612669","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":29,"triangles":51,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0000464","count":5},{"id":"GO:0000398","count":5},{"id":"GO:0006378","count":4}]},{"hash":"1135535223151536743","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":23,"triangles":26,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":7},{"id":"GO:0048025","count":6},{"id":"GO:0061158","count":5},{"id":"GO:0006376","count":4},{"id":"GO:0098908","count":4}]},{"hash":"380067023733787540","title":"Embryonic development and organ morphogenesis","description":"The top GO terms cluster around embryonic patterning and organ formation: cartilage morphogenesis, left/right pattern formation, placental and pancreatic development, EMT in endocardial cushion formation, and endocrine system development. While a couple of terms (telomere maintenance, phosphorylation) touch on broader cellular processes, the dominant signal is developmental morphogenesis and tissue differentiation during embryogenesis. This makes \u201cEmbryonic development and organ morphogenesis\u201d a concise, representative label.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0060806","count":2}]},{"hash":"1189389950200119259","title":"Transcription Regulation and mRNA Capping","description":"The top GO terms point to core gene expression control: DNA-templated transcription and negative regulation of transcription by RNA polymerase II, plus RNA (guanine-N7)-methylation (mRNA cap formation). Developmental and stress/immune-related terms appear as downstream contexts of transcriptional regulation, suggesting these proteins primarily participate in transcription regulation and RNA processing with secondary roles in development and defense signaling.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035264","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0036265","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0061113","count":3}]},{"hash":"724550999218253968","title":"Neural signaling and sensory perception","description":"The top GO terms cluster around neural signaling (Rho pathway), brain development, GABA signaling, light/detection of visual perception, and behaviors such as locomotion and pain regulation, suggesting proteins involved in nervous system signaling and sensory-driven behavior. A minor note is larval cuticle development, likely reflecting developmental context in insects, but the dominant theme remains neural signaling and sensory processing.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007266","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0008363","count":1},{"id":"GO:0007214","count":1}]},{"hash":"1463741450413475324","title":"Axon Guidance and Neural Crest Migration","description":"This cluster is strongly defined by GO terms related to axon guidance, neuron projection formation, and neural crest\u2013derived migration (e.g., semaphorin-plexin signaling, sympathetic neuron guidance, branchiomotor/trigeminal nerve organization), with supporting adhesion processes, suggesting a cohesive neural development function centered on axon pathfinding and neural crest dynamics.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0032516","count":3},{"id":"GO:0007413","count":3},{"id":"GO:0097491","count":3},{"id":"GO:0036486","count":3},{"id":"GO:1902287","count":3}]},{"hash":"2213630780335861370","title":"Developmental signaling and neural differentiation","description":"This cluster centers on development-related processes, especially neuron differentiation and lung development, with supporting signaling pathways such as calcineurin-NFAT and calcium-channel regulation. The mix of tissue- and process-related GO terms suggests a broad developmental signaling role across multiple tissues rather than a single, specific pathway, making a neural-development and signaling theme most representative.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030182","count":9},{"id":"GO:0005979","count":9},{"id":"GO:0000082","count":9},{"id":"GO:0032516","count":9},{"id":"GO:0031573","count":9}]},{"hash":"1214982169630400374","title":"Ribosome biogenesis and translational control","description":"The cluster is dominated by terms tied to ribosome construction and protein synthesis, including translation, ribosomal large/small subunit biogenesis and assembly, SSU rRNA maturation, tRNA processing, and regulation of translation initiation (eIF2\u03b1 phosphorylation). While a couple of terms (osteoblast differentiation, regulation of viral transcription) are present, the shared feature is ribosome assembly and translational regulation.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0001649","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0006413","count":2},{"id":"GO:0042273","count":2}]},{"hash":"13368154298709793","title":"Immune receptor signaling and developmental pathways","description":"The cluster contains GO terms centered on cell-surface receptor signaling (ephrin receptor signaling, serine/threonine kinase signaling, Wnt signaling) and immune-related processes (innate immune response, IL-7\u2013related response, B cell differentiation), with additional terms like PDGF response and planar polarity that reflect signaling networks involved in development and cell communication. This points to a cohesive theme of receptor-mediated signaling coordinating immune function and developmental pathways.","confidence":"Medium","size":9,"edges":12,"triangles":0,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045087","count":9},{"id":"GO:0036120","count":8},{"id":"GO:0048013","count":8},{"id":"GO:0043552","count":8},{"id":"GO:0001736","count":8}]},{"hash":"2055985891679877302","title":"Nucleobase and Urate Transporters","description":"The top GO terms are all transporter-related, centered on import of nucleobases (adenine, guanine, hypoxanthine, xanthine) and uracil, as well as urate across the plasma membrane, indicating these proteins function as membrane transporters for nucleobases/urates. Peripheral terms (P450 pathway, phospholipid dephosphorylation) are minor and do not define the cluster, so the dominant theme is nucleobase/urate transport.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042906","count":3},{"id":"GO:0098710","count":3},{"id":"GO:0098702","count":3},{"id":"GO:0015747","count":3},{"id":"GO:0035344","count":3}]},{"hash":"1852227106544822207","title":"DNA replication and cell cycle","description":"The cluster\u2019s top GO terms are dominated by nuclear DNA processes: DNA replication, mitotic and meiotic cell cycles, G1/S transition, DNA-templated transcription, and DNA repair. These indicate proteins mainly participate in genome maintenance and cell division. A few neuronal/other terms (response to cocaine, Schwann cell development, excitatory postsynaptic potential) appear but are likely incidental annotations rather than defining features of the cluster. Overall, the theme is DNA metabolism and cell cycle control.","confidence":"Medium","size":9,"edges":7,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0000278","count":4},{"id":"GO:0051973","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0006281","count":4}]},{"hash":"1119477488283216731","title":"Chromatin silencing and heterochromatin formation","description":"Most of the top GO terms describe chromatin-related processes, including heterochromatin formation, chromatin localization, and regulation of chromosome condensation and transcription via histone modifications. Although a few terms touch on differentiation and cell migration, the dominant theme is chromatin silencing and heterochromatin regulation, justifying this label.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030466","count":6},{"id":"GO:0000122","count":4},{"id":"GO:0061086","count":3},{"id":"GO:0000183","count":3},{"id":"GO:0071674","count":3}]},{"hash":"1426546279703896200","title":"Bacterial O-glycosylation and cell wall biosynthesis","description":"The top GO terms cluster around protein O-linked glycosylation (via Ser/Thr and GalNAc) and cell wall organization, plus a specific lipid-linked sugar donor biosynthetic process, pointing to roles in surface protein modification and bacterial cell wall assembly. Some terms (e.g., immunoglobulin production, brain segmentation) appear as noise or outdated annotations.","confidence":"High","size":9,"edges":26,"triangles":32,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":3},{"id":"GO:0071555","count":1},{"id":"GO:0018243","count":1},{"id":"GO:0036108","count":1},{"id":"GO:0006049","count":1}]},{"hash":"2207919609857739751","title":"Embryonic Organ Development","description":"This cluster is best described as embryonic organ development; the top GO terms cover forebrain, heart, eye, limb, placenta, gonadal, and other organ morphogenesis, indicating proteins involved in broad embryonic development and organ formation rather than a single tissue-specific function.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030900","count":3},{"id":"GO:2000288","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0060527","count":3},{"id":"GO:0003148","count":3}]},{"hash":"1834675133023977507","title":"Ubiquitin-Dependent Protein Degradation","description":"Top terms show a clear focus on ubiquitin tagging and proteasomal degradation (ubiquitin-dependent protein catabolic process, ubiquitin-dependent ERAD, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, protein polyubiquitination). This strongly indicates a cluster of proteins involved in the ubiquitin\u2013proteasome system and regulated proteolysis, with some peripheral links to circadian and stress responses. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0030433","count":5},{"id":"GO:0033280","count":4},{"id":"GO:0000209","count":3},{"id":"GO:0031146","count":3}]},{"hash":"493074369065063337","title":"Unknown","description":"The GO terms span RNA silencing, protein modification (phosphorylation and ubiquitination) and glycosylation, immune signaling, cytoskeletal organization, endocytosis regulation, cell division (spindle pole duplication), ER quality control, DNA repair, and more. With no interconnecting pathway or shared function evident and no interactions between proteins, there isn\u2019t a cohesive theme to name a specific cluster function beyond Unknown.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035278","count":4},{"id":"GO:0006468","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0060340","count":3},{"id":"GO:0000226","count":3}]},{"hash":"1564157969184605011","title":"Neural development and sensory perception","description":"The cluster's prominent terms center on brain development (cerebellar cortex development, thalamus development) and sensory processing (visual perception), suggesting a theme of neural development and brain function, despite a few metabolic or cell-cycle terms present as background annotations.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006006","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0071380","count":2},{"id":"GO:0071361","count":2},{"id":"GO:0032298","count":2}]},{"hash":"166294191705200932","title":"GPCR Signaling, Angiogenesis, and Bone Development","description":"The cluster is enriched for GPCR signaling terms (PLC-activating and adenylate cyclase-activating pathways), suggesting a core GPCR-driven signaling theme. It also features negative regulation of angiogenesis and VEGF signaling, along with bone development, pointing to a vascular\u2013skeletal development axis. Some terms on synapse assembly and growth hormone secretion indicate broader developmental signaling roles, but the dominant signal is GPCR-mediated pathways tied to vascular and skeletal regulation.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1900747","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0007200","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0007189","count":2}]},{"hash":"697768769715187053","title":"Innate Immunity and Coagulation","description":"The top GO terms point to innate immune functions (defense response to fungus, complement activation via the lectin pathway) and coagulation, suggesting a cluster centered on immune defense with hemostatic processes; additional terms related to signaling and development may reflect broader roles in tissue responses. Medium","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":7},{"id":"GO:0050832","count":6},{"id":"GO:0007596","count":6},{"id":"GO:1900738","count":6},{"id":"GO:0009791","count":6}]},{"hash":"1547121750163921378","title":"Hematopoietic and immune differentiation and signaling","description":"The top GO terms point to hematopoietic lineage processes (platelet formation, hematopoietic progenitor differentiation, B cell differentiation) and regulation of signaling pathways (tyrosine phosphorylation/STAT, PTP signaling, p38 MAPK), with a few neuron-related terms likely incidental. This pattern suggests the cluster includes proteins involved in blood/immune cell development and modulation of signaling cascades, rather than a single narrow function. Confidence: Medium","confidence":"","size":9,"edges":12,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030220","count":2},{"id":"GO:0071663","count":1},{"id":"GO:0045577","count":1},{"id":"GO:1903898","count":1},{"id":"GO:0042524","count":1}]},{"hash":"1979622681596025657","title":"Unknown","description":"The top terms are scattered across vesicle trafficking (Rab signaling, Cvt pathway) and various metabolic processes (nucleotide metabolism, redox, riboflavin biosynthesis, antibiotic response) with no single unifying function, indicating a mixed cluster rather than a coherent pathway.","confidence":"","size":9,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032482","count":2},{"id":"GO:0050771","count":2},{"id":"GO:0032258","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0055114","count":2}]},{"hash":"1956649062385965997","title":"Eicosanoid biosynthesis and inflammatory response","description":"The proteins show enrichment for lipid mediator pathways (lipoxygenase pathway, prostaglandin and leukotriene production) and inflammatory signaling (response to cytokines, chronic inflammatory response), along with oxidative stress and epidermal differentiation cues (cornification). This points to a coordinated role in eicosanoid biosynthesis driving inflammatory responses, potentially in skin/barrier contexts.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":2},{"id":"GO:2001300","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0070268","count":2},{"id":"GO:0019372","count":2}]},{"hash":"302423751033932541","title":"Glycosaminoglycan Proteoglycan Biosynthesis","description":"The terms show strong emphasis on biosynthesis and metabolism of glycosaminoglycans such as dermatan sulfate, heparan sulfate, and chondroitin sulfate, which are core components of proteoglycans in the extracellular matrix. Additional terms point to proteoglycan metabolism and related developmental processes (chondrocyte development and ureteric bud formation), consistent with ECM regulation during tissue growth. The single maltose transport term is an outlier, but the dominant theme remains proteoglycan/GAG biosynthesis.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033037","count":1},{"id":"GO:0050655","count":1},{"id":"GO:0015768","count":1},{"id":"GO:0030208","count":1},{"id":"GO:0030202","count":1}]},{"hash":"1013591016606661955","title":"Innate Immune Signaling and Cellular Stress Responses","description":"This cluster is dominated by GO terms related to innate immune signaling (MyD88-dependent TLR signaling) and broad cellular stress responses (response to toxins/toxic substances, ER-associated degradation, and proteasomal protein catabolism), with supporting hints from calcium signaling and endocytosis regulation. While a couple of terms relate to cell division or morphogenesis, the core theme ties immune signaling to protein homeostasis under stress.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0034126","count":8},{"id":"GO:0017085","count":8},{"id":"GO:1900186","count":8},{"id":"GO:1901896","count":8},{"id":"GO:0045759","count":8}]},{"hash":"197706100538345242","title":"Mitochondrial and chloroplast protein import","description":"The cluster shows strong enrichment for GO terms related to importing proteins into organelle compartments, notably mitochondrial matrix and inner membrane, and chloroplast stroma, suggesting a shared function in organelle protein import; other terms appear as weaker or ancillary associations.","confidence":"High","size":8,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":3},{"id":"GO:0045039","count":3},{"id":"GO:0032094","count":2},{"id":"GO:0045037","count":2},{"id":"GO:0000002","count":2}]},{"hash":"1847433456321145421","title":"Developmental morphogenesis and tissue remodeling","description":"This cluster centers on morphogenesis and remodeling across tissues, including branching morphogenesis in the lung (epithelial tube branching, terminal units), basement membrane remodeling, decidualization, and bone resorption, with regulatory influences from thyroid hormone signaling and neural precursor proliferation. The mix suggests a broad theme of developmental tissue remodeling rather than a single pathway. ","confidence":"Medium","size":8,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":4},{"id":"GO:0097067","count":3},{"id":"GO:2000179","count":3},{"id":"GO:0010815","count":3},{"id":"GO:0060448","count":3}]},{"hash":"735033495501389739","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":9,"triangles":3,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0071502","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0002024","count":2},{"id":"GO:1900745","count":1}]},{"hash":"1481972854126327919","title":"Unknown","description":"The top terms show partial support for neural development (axon guidance, cortex development) and adhesion, but also unrelated biosynthetic terms and an obsolete GO term, making a single coherent function hard to define.","confidence":"","size":8,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0042619","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0060396","count":2},{"id":"GO:0045793","count":2}]},{"hash":"1945458879726621262","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010269","count":2},{"id":"GO:0001889","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0055114","count":2}]},{"hash":"1118030192082544011","title":"Unknown","description":"The top GO terms are highly diverse, spanning development (heart development, post-embryonic development), immune signaling (negative regulation of T cell proliferation, positive regulation of chemokine production), metabolism (fatty acid beta-oxidation), and other stress or catabolic processes, with no clear single functional theme. There are no edges among the proteins to support a cohesive pathway, so a specific, common function cannot be inferred.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0051092","count":2},{"id":"GO:0046007","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0035234","count":2}]},{"hash":"45831731547925078","title":"Organogenesis and vesicle trafficking","description":"The terms cluster around broad developmental programs across nervous system, heart, kidney, and brain, combined with intracellular vesicle trafficking and Hedgehog signaling, suggesting a module linked to organogenesis and developmental signaling. The plant ABA term is likely noise.","confidence":"High","size":8,"edges":25,"triangles":39,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0009789","count":3},{"id":"GO:0001302","count":3}]},{"hash":"791993519950993273","title":"Neural development and gene expression","description":"The top GO terms include brain development, embryonic cranial skeleton morphogenesis, and associative learning, pointing to neural development. At the same time, several core gene-expression processes (DNA replication, DNA recombination, transcription regulation, mRNA splicing, translation) suggest these proteins also participate in general cellular machinery. Thus the cluster likely centers on neural development with supporting roles in transcription/translation processes, rather than a single tight pathway.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0008306","count":2}]},{"hash":"2301965883758705355","title":"Neuronal differentiation and calcium\u2013NFAT signaling","description":"This cluster is dominated by GO terms related to neural development and calcium-dependent signaling, notably neuron differentiation and the calcineurin-NFAT signaling cascade, along with a note of morphine response\u2014all indicative of neural signaling and development. Some terms appear unrelated (e.g., lipid A biosynthesis, cell cycle checkpoints), which are likely noise or misannotations, but the core theme centers on neural differentiation and calcium/NFAT pathways.","confidence":"Medium","size":8,"edges":6,"triangles":0,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009245","count":8},{"id":"GO:0030182","count":7},{"id":"GO:0005979","count":7},{"id":"GO:0000082","count":7},{"id":"GO:0032516","count":7}]},{"hash":"182745208465620292","title":"Steroid and lipid metabolism","description":"This cluster is driven by multiple lipid- and steroid-related biosynthetic and metabolic terms (glucocorticoid, C21-steroid, sphingolipid, mycolic acid, poly-hydroxybutyrate biosynthesis; plus steroid catabolic and tropane alkaloid biosynthesis), with a few related but broader terms (lung development, tetrahydrobiopterin). The unifying theme appears to be metabolism of steroids and lipids across diverse organisms, rather than a single specific pathway.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":4},{"id":"GO:0006704","count":4},{"id":"GO:0008207","count":4},{"id":"GO:0030148","count":4},{"id":"GO:0006706","count":4}]},{"hash":"1795474927408371549","title":"Amino acid and vitamin metabolism","description":"This cluster is dominated by GO terms for amino acid metabolism (L-alanine catabolic process, L-serine biosynthetic process) and vitamin biosynthesis (pyridoxine), plus related pathways like the shikimate metabolic process. These together suggest a shared theme of small-molecule metabolism, though a few terms (circadian cycle, sporulation) are more peripheral or context-dependent. The lack of interactions among members makes a tight functional label challenging, but a metabolic theme best captures the core functional signals.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0042853","count":3},{"id":"GO:0006564","count":3},{"id":"GO:0008615","count":3},{"id":"GO:0030435","count":3}]},{"hash":"2075146389017604079","title":"Fatty acid biosynthesis and long-chain lipid metabolism","description":"This cluster is dominated by GO terms related to fatty acid metabolism\u2014biosynthesis, and processing of long-chain, very long-chain, and medium-chain fatty acids, plus related transport (import) and acetyl-CoA biosynthesis links. Some auxiliary catabolic processes (propionate, phenylacetate) also tie into fatty acid\u2013related metabolic pathways, and a plant-specific term about seed germination may reflect lipid signaling or energy mobilization in seeds. Overall, the common theme is lipid metabolism centered on fatty acid synthesis and processing.","confidence":"High","size":8,"edges":6,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006633","count":3},{"id":"GO:0019629","count":3},{"id":"GO:0019518","count":2},{"id":"GO:0000038","count":2},{"id":"GO:0019427","count":2}]},{"hash":"1414050088663549367","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003273","count":3},{"id":"GO:0031424","count":3},{"id":"GO:0061146","count":3},{"id":"GO:0032773","count":3},{"id":"GO:0051796","count":3}]},{"hash":"1825432716840746707","title":"Cell Cycle and Signaling Network","description":"The cluster centers on mitotic processes (mitotic cell cycle, cell division, exit from mitosis) and several signaling pathways (T cell receptor signaling, ephrin receptor signaling, GTPase activity regulation) with growth-related processes like ribosome biogenesis; together these terms point to coordinated cell proliferation with broader signaling contexts across immune and vascular pathways.","confidence":"Medium","size":8,"edges":14,"triangles":11,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0043524","count":3},{"id":"GO:0010458","count":3}]},{"hash":"234340298564806459","title":"Endothelial ECM remodeling and angiogenesis regulation","description":"The cluster is dominated by GO terms related to endothelial cell behavior (negative regulation of endothelial proliferation and angiogenesis, positive regulation of endothelial migration) and extracellular matrix processes (ECM constituent secretion, localization to extracellular region). These together point to functions at the interface of endothelial cells and the extracellular matrix, governing angiogenesis and ECM remodeling.","confidence":"High","size":8,"edges":12,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001937","count":1},{"id":"GO:0016525","count":1},{"id":"GO:0070278","count":1},{"id":"GO:0033591","count":1},{"id":"GO:0007165","count":1}]},{"hash":"2206049832663404361","title":"Plant transcription and chromatin regulation","description":"The set of GO terms centers on transcription initiation and regulation (RNA polymerase II promoter activity, regulation of DNA-templated transcription) along with chromatin-related processes (subtelomeric heterochromatin formation, histone exchange and histone acetylation). The inclusion of ncRNA-mediated post-transcriptional silencing and plant-development timing terms (vegetative-to-reproductive transition) suggests a broader regulatory network where transcription is modulated by chromatin state and RNA-based control, typical of plant gene expression regulation. Overall, the cluster represents transcriptional control intertwined with chromatin dynamics in plants.","confidence":"Medium","size":8,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006367","count":2},{"id":"GO:0006348","count":2},{"id":"GO:0007379","count":1},{"id":"GO:0043486","count":1},{"id":"GO:0042766","count":1}]},{"hash":"2225787552185480297","title":"Developmental transcription regulators","description":"The cluster centers on transcriptional control, with terms for regulation of DNA-templated transcription and RNA Pol II regulation, plus several development-related processes (pituitary gland development, PNS neuron development, blastocyst development, primitive streak formation), suggesting these proteins act as developmental transcription regulators.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0042208","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0021983","count":2}]},{"hash":"2272255610170634679","title":"Hematopoietic and Immune Differentiation with Transcriptional Regulation","description":"This cluster mixes terms tied to development of blood/immune lineages (angioblast/hemocyte/macrophage differentiation, somatic stem cell maintenance, blood circulation) with transcriptional and epigenetic control (negative regulation of transcription by RNA Pol II, CpG methylation). The common thread appears to be differentiation of hematopoietic/immune cells governed by transcriptional regulation, with some vascular development context. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0035779","count":1},{"id":"GO:0044027","count":1},{"id":"GO:0060233","count":1},{"id":"GO:0035019","count":1}]},{"hash":"1979273520226724821","title":"Unknown","description":"There are no shared GO terms to bind these proteins into a common function; the cluster has only one edge and no triangles, giving no obvious theme. ReCIPE re-additions alone don't establish a coherent role.","confidence":"","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[]},{"hash":"785695112207502195","title":"Vacuolar amino acid import","description":"Most of the listed GO terms describe transmembrane import of amino acids (glutamate, serine, histidine, arginine, alanine) into the vacuole, plus related transport regulation, suggesting a cluster of vacuolar amino acid transport proteins; a single outlier about root cap development is likely noise. This label captures the common function across the cluster. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048829","count":1},{"id":"GO:0090515","count":1},{"id":"GO:0090516","count":1},{"id":"GO:0089708","count":1},{"id":"GO:0090452","count":1}]},{"hash":"921323542306192649","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000389","count":1},{"id":"GO:0000350","count":1},{"id":"GO:0000380","count":1},{"id":"GO:0050909","count":1},{"id":"GO:0000480","count":1}]},{"hash":"2005365675512987614","title":"Mitochondrial Outer Membrane Import Machinery","description":"The GO terms that stand out are outer mitochondrial membrane organization and mitochondrial outer membrane translocase complex assembly, which together point to mitochondrial protein import machinery (TOM complex). The remaining terms (cell cycle and differentiation) are less cohesive with this theme, suggesting a primary mitochondrial import focus for the cluster.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2000495","count":1},{"id":"GO:0002318","count":1},{"id":"GO:0007050","count":1},{"id":"GO:0007008","count":1},{"id":"GO:0070096","count":1}]},{"hash":"1505652309529339097","title":"Neuronal ion transport and synaptic signaling","description":"The top GO terms cluster around sodium and potassium ion transmembrane transport, membrane depolarization, and excitatory postsynaptic potentials, with coherent involvement of neurotransmitter signaling pathways (GABA and acetylcholine) and even drug-response related terms like cocaine. This points to ion channel\u2013driven synaptic transmission and neural signaling as the defining theme of the group.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":7},{"id":"GO:0071805","count":7},{"id":"GO:0060079","count":7},{"id":"GO:0051899","count":7},{"id":"GO:0045759","count":6}]},{"hash":"1428710394613642380","title":"Symbiont-host Immune Interaction","description":"This cluster is dominated by GO terms related to host immune processes and how symbionts interact with or evade host defenses (e.g., T cell receptor signaling, symbiont-mediated evasion of host immune response). While there are additional terms pointing to bacterial metabolism (nitrogen fixation, ammonia assimilation, glucose response) that fit a symbiotic lifestyle, the strongest recurring themes are host\u2013microbe communication and immune modulation, suggesting proteins involved in symbiotic host interaction rather than a purely host- or microbe-centric function. Confidence: Medium","confidence":"","size":8,"edges":10,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":3},{"id":"GO:0009399","count":2},{"id":"GO:0044044","count":2},{"id":"GO:0020012","count":2},{"id":"GO:0009749","count":2}]},{"hash":"1078197856347954079","title":"Chitin Catabolism and Inflammatory Mediator Production","description":"The cluster\u2019s top terms center on chitin catabolic process and carbohydrate metabolic processes, along with production and positive regulation of inflammatory mediators and chemokines. This points to a cohesive theme where chitin degradation is linked to innate immune signaling and inflammatory mediator production, rather than a purely metabolic or signaling module. Some additional terms appear as older or regulatory annotations, but the core signal combines chitin metabolism with inflammatory response.","confidence":"Medium","size":8,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0005975","count":2},{"id":"GO:0002532","count":2},{"id":"GO:0006032","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0075525","count":1}]},{"hash":"911316445686024997","title":"Developmental signaling and organogenesis","description":"Enriched terms center on multicellular development and organogenesis (heart, nervous system, placenta) with signaling pathways (VEGF, prostaglandin, BCR) and phosphorylation, suggesting a developmental signaling role.","confidence":"High","size":8,"edges":11,"triangles":7,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0010765","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0007275","count":6},{"id":"GO:0035924","count":6},{"id":"GO:0050853","count":6}]},{"hash":"402287031738806617","title":"DNA transposition and proviral integration","description":"The top GO terms cluster around genome mobility: DNA integration, DNA transposition, retrotransposition, and proviral latency, plus viral entry/penetration into host nuclei. These point to transposable elements and proviruses rather than a single enzyme or pathway, despite some ancillary terms. This name captures the central theme of mobile genetic elements and host-virus integration events.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0075713","count":1},{"id":"GO:0075732","count":1},{"id":"GO:0032197","count":1}]},{"hash":"633564539537320803","title":"Core Cell Cycle and Proteostasis","description":"The terms point to central cellular processes: mitotic spindle assembly and chromatin assembly relate to cell division, ubiquitin-dependent degradation and prote catabolism to protein turnover, transcription and ER-Golgi transport to gene expression and trafficking. While there is a small signal for innate immune response, the dominant themes are cell cycle\u2013related and proteostasis/trafficking processes, suggesting a cluster of housekeeping proteins rather than a single immune pathway. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0090307","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0030433","count":3}]},{"hash":"1720386936249146120","title":"Golgi/ER trafficking and polarity","description":"This cluster shows a core theme of intracellular organization and protein handling, with GO terms for Golgi organization, protein transmembrane transport, and regulation of the ER unfolded protein response, plus establishment/maintenance of apical/basal polarity. While a few terms are peripheral (e.g., signaling or vascular terms), the dominant signals point to trafficking and organelle organization within the secretory pathway and associated polarity maintenance.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007030","count":2},{"id":"GO:0001998","count":1},{"id":"GO:0071806","count":1},{"id":"GO:0048013","count":1},{"id":"GO:0034260","count":1}]},{"hash":"262922115588164798","title":"Steroid and lipid biosynthesis","description":"Top GO terms indicate a cohesive theme of biosynthetic processes for steroids, lipids, and related metabolites (glucocorticoid biosynthesis, C21-steroid hormone metabolism, sphingolipid and mycolic acid biosynthesis, tetrahydrobiopterin biosynthesis, tropane alkaloid biosynthesis), suggesting the cluster centers on lipid- and hormone-related synthesis pathways. The inclusion of a lung development term may reflect tissue-specific roles or secondary associations, but the dominant signal remains biosynthesis of steroid and lipid compounds.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0042619","count":6},{"id":"GO:0006704","count":6},{"id":"GO:0008207","count":6},{"id":"GO:0030148","count":6}]},{"hash":"1476176721004620396","title":"Cardiac Ion Transport and Muscle Relaxation","description":"This cluster centers on ion transport and electrical activity relevant to cardiac function: potassium import, magnesium transport, regulation of membrane repolarization, and relaxation of cardiac muscle. These terms strongly point to a shared role in cardiac ion homeostasis and excitability. The other terms (responses to ATP/glucose, estradiol, protein tetramerization, CNS myelination, BMP signaling) may reflect broader signaling roles or protein family associations but do not override the core theme.","confidence":"Medium","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0032355","count":2},{"id":"GO:0060306","count":2},{"id":"GO:0033198","count":2},{"id":"GO:0051289","count":2},{"id":"GO:1990573","count":2}]},{"hash":"1026462584995882980","title":"Broad-spectrum membrane transporters","description":"The top GO terms are dominated by various membrane transport processes for diverse substrates (4-hydroxyphenylacetate, L-ascorbic/dehydroascorbic acid, D-xylose, phosphate, nitrate, and Na+/K+), indicating a cluster of transporter proteins with broad substrate specificity. The presence of an osmotic stress response term also aligns with transporter function in solute balance. This supports labeling as broad-spectrum membrane transporters.","confidence":"High","size":8,"edges":22,"triangles":27,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":8},{"id":"GO:0019852","count":8},{"id":"GO:0042908","count":8},{"id":"GO:0070837","count":8},{"id":"GO:0015753","count":8}]},{"hash":"516333267192013620","title":"Cardiovascular signaling and smooth muscle regulation","description":"Most terms describe cardiovascular function and vascular regulation (heart development; vasodilation; vascular permeability; smooth muscle contraction regulation; blood pressure), with supporting signaling pathways (ERK cascade, cAMP/PKA). While a couple of terms point to immune-related responses, the dominant theme is heart/vascular signaling and smooth muscle control.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0042742","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0090075","count":2},{"id":"GO:0043114","count":2}]},{"hash":"1239968564217751180","title":"Cell-cycle regulation and transcriptional control","description":"The cluster centers on cell-cycle processes (G1/S transition, regulation of the cell cycle, mitotic spindle pole separation) and transcriptional control (RNA polymerase II transcription), with supporting signals from pathways like Wnt that can drive proliferation. Some terms reflect development and stress responses, but the dominant theme appears to be coordination of cell-cycle progression with transcriptional regulation and signaling. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060070","count":1},{"id":"GO:0006366","count":1},{"id":"GO:0000082","count":1},{"id":"GO:0060153","count":1},{"id":"GO:0010696","count":1}]},{"hash":"512753185568039229","title":"Exocyst-Driven Exocytosis","description":"This cluster is dominated by GO terms for exocytosis and exocyst components (exocytosis, exocyst localization, exocyst assembly, dense core granule transport). Additional terms point to vesicle/secretory organelle trafficking (lysosomal transport, ER inheritance, intracellular sphingolipid homeostasis). Together these indicate a coherent function in vesicle trafficking and regulated secretion via the exocyst complex.","confidence":"High","size":8,"edges":6,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006887","count":2},{"id":"GO:0051601","count":2},{"id":"GO:1904811","count":1},{"id":"GO:0001927","count":1},{"id":"GO:0048309","count":1}]},{"hash":"1933953095819229902","title":"Neural Pain Perception and Visual Processing","description":"The top GO terms point to neural sensory functions: perception of pain, responses to morphine and amphetamine, and prepulse inhibition, along with phototransduction and visual learning. These converge on sensory processing and learning in neural circuits, particularly related to pain and vision; a couple of terms (GTPase activity regulation, cell wall macromolecule catabolic) are less specific and may be incidental. Overall, the cluster appears to represent neural sensory signaling and visual processing.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":2},{"id":"GO:0051930","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0060134","count":2},{"id":"GO:0001975","count":2}]},{"hash":"881949230099685027","title":"Neural signaling and innervation","description":"The most represented terms center on neural function: regulation of action potential, GABA signaling, acetylcholine response, sensory processing, innervation, and ion transport. Additional associations with cocaine and histamine reflect neuromodulatory signaling. Together these terms suggest a cluster of proteins involved in neuronal signaling and innervation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045759","count":8},{"id":"GO:0042220","count":8},{"id":"GO:0050893","count":8},{"id":"GO:0071294","count":8},{"id":"GO:0007214","count":8}]},{"hash":"1180851631418498559","title":"Broad developmental programs","description":"The top GO terms point to development across various tissues (embryonic patterning, organ development, neuron and T cell development). Since there isn't a single cohesive function linking all terms, the cluster seems to represent broad developmental processes rather than a specific pathway.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050798","count":1},{"id":"GO:0009880","count":1},{"id":"GO:0043374","count":1},{"id":"GO:0021902","count":1},{"id":"GO:0060021","count":1}]},{"hash":"1821062703324005811","title":"Collagen biosynthesis and cartilage development","description":"This cluster centers on collagen production and organization (collagen fibril organization; collagen biosynthetic process) and cartilage-related developmental processes (growth plate cartilage chondrocyte development; cartilage development in endochondral bone morphogenesis), suggesting a shared role in extracellular matrix assembly and skeletal tissue formation. Other terms like cell adhesion and oviduct morphogenesis point to broader developmental contexts, while the immune-related and PDGF signaling terms are less central; overall the dominant theme is collagen-rich ECM and skeletal development.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":1},{"id":"GO:0051873","count":1},{"id":"GO:0060351","count":1},{"id":"GO:0035987","count":1},{"id":"GO:0003431","count":1}]},{"hash":"782487059099985330","title":"Pollen Development and Nucleotide Catabolism","description":"This cluster is anchored by pollen-related GO terms (anther dehiscence and pollen exine formation), pointing to plant pollen development. The other terms\u2014nucleotide catabolic processes (ADP, GDP, UDP, CDP), mRNA export, and protein N-linked glycosylation\u2014suggest general cellular metabolism and protein processing that are active during reproductive tissue differentiation. Taken together, the cluster seems to reflect pollen development with associated metabolic and processing activities.","confidence":"Medium","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0032508","count":2},{"id":"GO:0046032","count":1},{"id":"GO:0046712","count":1},{"id":"GO:0009901","count":1},{"id":"GO:0071405","count":1}]},{"hash":"2232046364508076630","title":"Ubiquitin-mediated protein modification and signaling","description":"The proteins cluster around ubiquitination-related processes (protein ubiquitination, autoubiquitination, ubiquitin-dependent ERAD) and SUMOylation, with links to regulatory signaling and stress responses (negative regulation of transcription, TORC1 signaling, amino acid starvation responses, and TNF signaling). This suggests a coherent theme of post-translational modification by ubiquitin/SUMO and its downstream effects on cellular signaling and survival.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045648","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0016925","count":2},{"id":"GO:0051865","count":2},{"id":"GO:1903265","count":2}]},{"hash":"1281142232749923764","title":"Ubiquitin-Dependent Regulation of Immune Signaling and Apoptosis","description":"The cluster is dominated by ubiquitin-related processes (ubiquitin-dependent protein catabolic process, protein ubiquitination) and regulatory signaling linked to immunity and cell fate (apoptosis, I-kappaB phosphorylation/NF-\u03baB, T follicular helper cell differentiation). This suggests a cohesive theme around ubiquitin-mediated control of immune signaling and apoptosis. ","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0042981","count":4},{"id":"GO:0002635","count":4},{"id":"GO:1903762","count":4},{"id":"GO:0000122","count":4}]},{"hash":"966534807645287386","title":"Unknown","description":"The GO terms are heterogeneous\u2014ranging from sperm DNA condensation and neuron differentiation to spindle assembly and centrosome cycle\u2014with several entries marked obsolete. There is no clear, shared function connecting these proteins, and the lack of edges further suggests no cohesive theme. Therefore, I cannot assign a confident, specific name.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070511","count":1},{"id":"GO:0035093","count":1},{"id":"GO:0021895","count":1},{"id":"GO:0072553","count":1},{"id":"GO:0051225","count":1}]},{"hash":"2300676462161716642","title":"Unknown","description":"This set of GO terms spans immune signaling regulation, ERAD/ubiquitin pathways, nuclear membrane dynamics, lipid droplet organization, cell death, and chromatid orientation, with no evident shared function or cohesive pathway among the proteins; therefore a single meaningful label cannot be assigned beyond Unknown.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007253","count":1},{"id":"GO:0061060","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0031468","count":1},{"id":"GO:0034389","count":1}]},{"hash":"924007562440560517","title":"Salivary gland development and epithelial polarity","description":"The top GO terms point to submandibular salivary gland formation and apical/basal cell polarity, suggesting a theme of gland development and epithelial organization. Additional terms about ephrin signaling and membrane transport support a broader epithelial signaling context relevant to secretory gland morphogenesis, even though some terms are obsolete or general. Overall, a cohesive label around gland development and epithelial polarity best captures the cluster\u2019s likely function.","confidence":"Medium","size":7,"edges":11,"triangles":3,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001998","count":3},{"id":"GO:0071806","count":3},{"id":"GO:0048013","count":3},{"id":"GO:0034260","count":3},{"id":"GO:0043497","count":3}]},{"hash":"316431929322675221","title":"Unknown","description":"There are no GO terms provided for this cluster (Top Terms is empty), so I can't identify a unifying function. With 7 proteins and a network of 15 edges and 14 triangles, there is not enough functional information to derive a common theme, so the label remains Unknown.","confidence":"","size":7,"edges":15,"triangles":14,"max_degree":6,"top_function":null,"top_go_terms":[]},{"hash":"1545215087142634298","title":"Ubiquitin-regulated immune signaling","description":"The proteins in this cluster show enrichment for ubiquitination-related processes (ubiquitin-dependent protein catabolic process; K33-linked ubiquitination; negative regulation of protein ubiquitination) alongside immune-function terms (positive regulation of dendritic cell differentiation; negative regulation of mast cell cytokine production; negative regulation of IgE isotype switching). This suggests a cohesive role in modulating immune signaling through ubiquitin-dependent pathways. Some GO terms appear unrelated or obsolete, but the dominant theme ties ubiquitin regulation to immune cell differentiation and signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032764","count":3},{"id":"GO:0042787","count":3},{"id":"GO:2000312","count":3},{"id":"GO:1904431","count":3},{"id":"GO:0045497","count":3}]},{"hash":"702984164049704019","title":"Unknown","description":"The top GO terms span insect cuticle development, B cell differentiation/signaling, endothelial barrier and tight junction assembly, various aspects of neural development (substantia nigra, myelination, sensory perception of sound), and extrinsic apoptotic signaling. This broad mix across immune, neural, barrier, and non-animal-specific processes provides no single cohesive function to define the cluster, so a concise, representative label cannot be confidently assigned.","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0002337","count":1},{"id":"GO:0061028","count":1},{"id":"GO:0070830","count":1},{"id":"GO:0021762","count":1}]},{"hash":"495042284877100797","title":"Muscle contraction regulation and sarcomere organization","description":"The top GO terms cluster around muscle function, including regulation of ATP-dependent activity, muscle contraction, muscle filament sliding, sarcomere organization, and cardiac muscle development. This points to proteins involved in the muscle contraction apparatus and its regulation rather than non-muscle processes.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032780","count":4},{"id":"GO:0006940","count":4},{"id":"GO:0030049","count":4},{"id":"GO:0045214","count":4},{"id":"GO:0045932","count":4}]},{"hash":"335734432607792433","title":"Biosynthesis and xenobiotic detoxification","description":"This cluster shows enrichment for several biosynthetic processes (biotin, antibiotic, polyamine, sterol, ubiquinone) indicating a shared role in metabolic biosynthesis, along with a cellular response to xenobiotic stimulus and detoxification of oxidants, suggesting a coordinated metabolism with stress handling. Translation appears as a general cellular process and nodulation may be incidental. Overall, the theme centers on biosynthetic pathways with detoxification responses rather than a single specific function, so Medium confidence.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009102","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006596","count":1}]},{"hash":"728537632359379925","title":"Unknown","description":"The listed GO terms span RNA processing (siRNA, tRNA) and translational control, but also many unrelated developmental and immune processes, with no single dominant theme. With only a few connections and diverse functions, there isn't a coherent function to label the cluster.","confidence":"","size":7,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0046782","count":1},{"id":"GO:0030422","count":1},{"id":"GO:0060384","count":1},{"id":"GO:0010998","count":1},{"id":"GO:0048899","count":1}]},{"hash":"1382559153222755453","title":"Calcium-dependent vesicle trafficking and autophagy","description":"This cluster centers on Ca2+-regulated membrane processes, including lysosome exocytosis, autophagy-related ribophagy, and IP3-mediated Ca2+ signaling, with supporting links to phagocytosis, cytoskeletal remodeling, and vesicle transport seen in synaptic and developmental contexts. The mix suggests a theme around calcium-triggered vesicle dynamics and related autophagic pathways, though some terms are peripheral, so confidence is Medium.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0032959","count":1},{"id":"GO:1901002","count":1},{"id":"GO:0050764","count":1},{"id":"GO:0060291","count":1}]},{"hash":"2045763645243739710","title":"Unknown","description":"The top terms span insect cuticle development, B cell differentiation, endothelial barrier formation, tight junction assembly, neural development, sensory perception, adhesion regulation, apoptosis signaling, and myelination. This broad mix shows no single cohesive function tying the proteins together, suggesting a heterogeneous or misannotated cluster rather than a distinct module.","confidence":"","size":7,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0002337","count":1},{"id":"GO:0061028","count":1},{"id":"GO:0070830","count":1},{"id":"GO:0021762","count":1}]},{"hash":"1009485211499062836","title":"Embryonic Eye and Brain Development with Ion Transport","description":"This cluster prominently features GO terms for ion transmembrane transport (sodium and potassium) alongside several embryonic development terms focused on eye and brain structures (embryonic eye morphogenesis, forebrain/midbrain development, camera-type eye development) and patterning. The combination suggests proteins that may be involved in both ion transport and embryonic neural/eye development, or a mix of functions common to early development processes. The label aims to capture these two central themes without overcommitting to a single precise function.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0060971","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0007275","count":2}]},{"hash":"2217914393323183846","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006977","count":2},{"id":"GO:0000495","count":2},{"id":"GO:0031119","count":2},{"id":"GO:1990481","count":2},{"id":"GO:0031118","count":2}]},{"hash":"2180936340060015131","title":"Immune activation and leukocyte recruitment","description":"The Top Terms are dominated by immune-related processes: complement activation (classical pathway), positive regulation of cytokine production, neutrophil extravasation, and gamma-delta T cell activation. These indicate the cluster genes are linked to innate/adaptive immune signaling and leukocyte recruitment. Some terms such as olfactory lobe development, salivary gland morphogenesis, and SA node action potential are less connected; they may reflect multifunctional proteins or annotation noise, but the strongest common thread is immune activation and leukocyte trafficking.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0046629","count":2},{"id":"GO:0021988","count":2},{"id":"GO:0060445","count":2}]},{"hash":"104374801421207404","title":"Innate and Adaptive Immune Response","description":"The top GO terms are dominated by immune-related processes: responses to lipopolysaccharide and virus, innate immune response, and defense against viruses, plus adaptive-immune signals such as T follicular helper cell differentiation and germinal center formation. Although there are a couple of outliers (ubiquitin-dependent proteolysis and muscle relaxation), the overall pattern points to coordinated innate and adaptive immune activity.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043278","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0002635","count":2},{"id":"GO:0061470","count":2}]},{"hash":"1276143398366685443","title":"B Cell Signaling and Differentiation","description":"The top GO terms center on B cell\u2013related signaling and development (B cell receptor signaling, follicular B cell differentiation) with supportive terms for thymus development and cell migration/lamellipodium assembly, indicating a cluster focused on B cell activation, differentiation, and associated motility. Confidence: High","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0050731","count":5},{"id":"GO:0071560","count":5},{"id":"GO:0032959","count":4},{"id":"GO:0043552","count":4}]},{"hash":"452780131736766870","title":"Potassium Transport and Membrane Potential Regulation","description":"The cluster centers on activities governing membrane potential maintenance and potassium handling\u2014potassium ion transport, intracellular potassium ion homeostasis, regulation and stabilization of resting membrane potential, and repolarization. Some associated terms relate to membrane\u2011bound organelle organization (nuclear envelope, ER), which fits a broader membrane\u2011associated context, but the strongest signal is potassium transport and membrane potential control.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071763","count":1},{"id":"GO:0090435","count":1},{"id":"GO:0007029","count":1},{"id":"GO:0032781","count":1},{"id":"GO:0060075","count":1}]},{"hash":"1656632873439193850","title":"Growth Factor Signaling and Morphogenesis","description":"The cluster is enriched for receptor-mediated signaling pathways (PDGF receptor signaling, ephrin receptor signaling) and processes tied to cell growth, cytoskeletal dynamics, and branching morphogenesis (mammary gland duct branching, actin reorganization). It also includes neuronal development and synaptic potentiation terms, suggesting a broader theme of growth factor signaling guiding development and morphogenesis across tissues, with some noise from unrelated terms like innate immunity. ","confidence":"Medium","size":7,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0007118","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0010641","count":4},{"id":"GO:0060444","count":4},{"id":"GO:0048666","count":4}]},{"hash":"1873399998627054296","title":"Steroid Biosynthesis and Cardiac Electrophysiology","description":"Top terms show cortisol, aldosterone, androgens, and testosterone biosynthesis, indicating steroid hormone biosynthesis, while terms on AV node, heart rate regulation, and atrial/ventricular electrical activity point to cardiac conduction. The cluster thus seems to group proteins involved in steroid metabolism with a secondary link to cardiac physiology; a few terms are more general (development/ossification).","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034651","count":2},{"id":"GO:0032342","count":2},{"id":"GO:0008209","count":2},{"id":"GO:0061370","count":2},{"id":"GO:0086091","count":2}]},{"hash":"403484479441333048","title":"RNA metabolism and translation control","description":"The cluster shows a strong signal for RNA biology: ribosomal small subunit biogenesis, translation, rRNA export, regulatory ncRNA-mediated gene silencing, and miRNA catabolic regulation. While a few terms (neuronal action potential regulation, dorsal appendage formation, host-mediated perturbation of viral RNA genome replication) are more divergent, the dominant RNA-processing and translation-related terms support this label. Medium","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0098908","count":2},{"id":"GO:0042274","count":2},{"id":"GO:2000627","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0006412","count":2}]},{"hash":"1616578993909105388","title":"Ubiquitination-Driven Immune Regulation","description":"The cluster is dominated by ubiquitin-related processes (ubiquitin-dependent protein catabolic process; K33-linked ubiquitination; regulation of protein ubiquitination) and immune system modulation (mast cell cytokine production, dendritic cell differentiation, IgE isotype switching). This suggests a cohesive theme where ubiquitination controls immune signaling and cell differentiation, despite a few miscellaneous terms present. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0032764","count":5},{"id":"GO:2000312","count":5},{"id":"GO:1904431","count":5},{"id":"GO:0045497","count":5}]},{"hash":"178809160511030529","title":"Ubiquitin and Neddylation in DNA Repair and Immunity","description":"The cluster features enrichment for ubiquitin-related processes (K11-linked ubiquitination) and neddylation, along with DNA repair activities (homologous recombination, DNA repair) and innate immune signaling (TRIF-dependent TLR and stimulatory C-type lectin receptor pathways). This suggests a cohesive module where ubiquitin-like modifications regulate genome maintenance and immune responses, even though some terms are obsolete and chromatin-related processes (like histone modification) may indirectly connect to these functions.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0070979","count":7},{"id":"GO:0035666","count":7},{"id":"GO:0051026","count":7},{"id":"GO:0002223","count":7},{"id":"GO:0031058","count":7}]},{"hash":"1521112993331179696","title":"Mitotic spindle and cell division","description":"These proteins are enriched for mitosis- and spindle-related terms: cell division, mitotic cytokinesis, spindle pole body duplication, microtubule nucleation, spindle midzone assembly, and cell cycle, indicating a cohesive role in mitotic machinery. A few neuron-related terms appear but likely reflect shared microtubule/cytoskeletal functions rather than a neuronal-specific process. ","confidence":"High","size":7,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:1902408","count":3},{"id":"GO:1903087","count":3},{"id":"GO:0090529","count":3},{"id":"GO:2000767","count":3}]},{"hash":"33831606136678545","title":"Polysaccharide metabolism","description":"The GO terms cluster around carbohydrate metabolism, including alpha-glucan, starch, maltose, trehalose, amylopectin, and glycogen biosynthesis and catabolism. This pattern points to proteins involved in both synthesis and breakdown of major polysaccharides, indicating a general polysaccharide metabolism role rather than a single pathway.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051692","count":3},{"id":"GO:0030980","count":3},{"id":"GO:0000023","count":3},{"id":"GO:0005983","count":3},{"id":"GO:0005992","count":3}]},{"hash":"514803494814368639","title":"RNAP II Transcription and Chromatin Remodeling","description":"This cluster is dominated by GO terms for RNA polymerase II\u2013mediated transcription (initiation, preinitiation complex assembly, elongation) and chromatin-related processes (histone acetylation/deubiquitination, chromatin remodeling), suggesting a functional module of transcription regulation tied to chromatin state. Some developmental terms appear as broader downstream effects, but the core signal points to transcription machinery and chromatin modification. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007124","count":2},{"id":"GO:0009960","count":2},{"id":"GO:0051123","count":2},{"id":"GO:0006366","count":2},{"id":"GO:0001403","count":2}]},{"hash":"1540482658984862046","title":"Ubiquitin-dependent regulation of immune signaling","description":"The top GO terms center on ubiquitin-mediated processes (ubiquitin-dependent protein catabolic process; K33-linked ubiquitination; regulation of protein ubiquitination), with several immune-related annotations (mast cell cytokine production, IgE isotype regulation, dendritic cell differentiation). This suggests a cluster focused on ubiquitin-mediated protein turnover that modulates immune signaling and immune cell differentiation.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0032764","count":4},{"id":"GO:2000312","count":4},{"id":"GO:1904431","count":4},{"id":"GO:0045497","count":4}]},{"hash":"1419718093720671054","title":"Proteoglycan/GAG Biosynthesis","description":"This cluster is dominated by GO terms for the biosynthesis and metabolism of proteoglycans and glycosaminoglycans (dermatan sulfate, heparan sulfate/heparin, chondroitin sulfate), indicating a shared role in extracellular matrix proteoglycan production. The presence of chondrocyte development reinforces a cartilage/ECM context. A few terms (like maltose transport) may reflect annotation noise or broader glycan-related functions. ","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010493","count":2},{"id":"GO:0033037","count":1},{"id":"GO:0050655","count":1},{"id":"GO:0015768","count":1},{"id":"GO:0030208","count":1}]},{"hash":"1771674765361269129","title":"Unknown","description":"The GO terms cover carbohydrate metabolism, neural differentiation, hormone signaling, cytoskeletal organization, and morphogenesis across plants, insects, and vertebrates, with no single cohesive function tying them together, so there isn't a clear, representative label for this cluster.","confidence":"","size":7,"edges":18,"triangles":22,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0005975","count":2},{"id":"GO:0021527","count":2},{"id":"GO:0071657","count":2},{"id":"GO:2000324","count":2},{"id":"GO:0097067","count":2}]},{"hash":"1773675147984997961","title":"Flavonoid glycosylation and lignin biosynthesis","description":"This cluster is dominated by GO terms tied to flavonoid metabolism (quercetin O-glucoside biosynthesis, genistein response) and lignin biosynthesis, pointing to flavonoid glycosylation and phenylpropanoid-derived cell-wall formation. The presence of glycosylation/glucuronidation-related terms supports a theme of metabolite modification and detoxification of xenobiotics. A single outlier term about paranode localization is likely noise, but the core signals reflect flavonoid processing and lignin biosynthesis. ","confidence":"Medium","size":7,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033303","count":4},{"id":"GO:0002175","count":4},{"id":"GO:0030259","count":4},{"id":"GO:0052697","count":4},{"id":"GO:0016999","count":4}]},{"hash":"1359819851813840620","title":"Carbohydrate and isoprenoid metabolism","description":"The top GO terms cover carbohydrate metabolic processes (galactose, galactitol, galacturonate, glycolytic flow from galactose) alongside isoprenoid/lipid biosynthesis pathways (MEP and mevalonate, farnesyl diphosphate, cholesterol). This suggests a cluster of proteins involved in broad metabolic processes rather than a single, narrow function.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042352","count":1},{"id":"GO:0019288","count":1},{"id":"GO:0046835","count":1},{"id":"GO:0000435","count":1},{"id":"GO:0006695","count":1}]},{"hash":"91582332328343206","title":"Metabolism and metal ion transport","description":"The cluster\u2019s GO terms span several metabolic processes (carbohydrate metabolism, serine biosynthesis, stilbene and sialic acid biosynthesis) along with lipid remodeling and intracellular calcium homeostasis, plus zinc and cadmium ion transmembrane transport and a testosterone response. This suggests a broad metabolic/regulatory role with a notable emphasis on membrane-associated ion transport, rather than a single tight pathway.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0019373","count":3},{"id":"GO:0046839","count":3},{"id":"GO:0006564","count":3},{"id":"GO:0006874","count":3},{"id":"GO:0046272","count":3}]},{"hash":"113049909023047707","title":"Unknown","description":"There are no GO terms or interactions to indicate a shared function among the seven proteins, so no unifying theme is evident.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"268099525374089005","title":"Cytoskeletal remodeling and MAPK signaling","description":"The cluster highlights cytoskeletal dynamics (stress fiber assembly) and signaling pathways (positive regulation of ERK1/ERK2 cascade, positive regulation of Rho signaling) that coordinate cell shape changes and proliferative signaling. Additional terms about GPCR internalization, transcription, and ubiquitination suggest integrated signaling and regulatory processes, pointing to a cohesive role in signal-driven cytoskeletal remodeling and cell cycle progression.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043149","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0000082","count":2},{"id":"GO:0090240","count":1},{"id":"GO:0045494","count":1}]},{"hash":"195440534439047380","title":"Ubiquitin-Proteasome Proteolysis and Neuronal Stress","description":"Top terms show a strong emphasis on ubiquitin-dependent protein catabolism, including SCF-dependent proteasomal pathways, indicating a proteolysis-focused cluster. Additional terms point to neuronal context and stress responses, such as synapse assembly, oxidative stress-induced neuronal apoptosis, and methylmercury response, along with regulatory signals like NF-kappaB and circadian rhythm. Taken together, these terms suggest a set of proteins tied to proteostasis with links to neuronal stress signaling rather than a purely cell-cycle or transcription-focused group. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0031146","count":3},{"id":"GO:0007250","count":2},{"id":"GO:0042752","count":2},{"id":"GO:0060386","count":2}]},{"hash":"705990760891238515","title":"GPI-anchor biosynthesis and protein glycosylation","description":"Most terms point to glycosylation and GPI-anchor biology: GPI anchor biosynthesis, attachment of GPI to proteins, dolichol-linked and N-linked glycosylation. The presence of these terms across multiple proteins suggests a functional cluster in post-translational modification and membrane anchoring, with a few terms reflecting broader glycoprotein roles in different organisms.","confidence":"High","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006506","count":2},{"id":"GO:0006490","count":2},{"id":"GO:0016255","count":1},{"id":"GO:0031505","count":1},{"id":"GO:0046425","count":1}]},{"hash":"573160541868294477","title":"Actin-based migration and signaling","description":"The cluster centers on actin-driven structures like lamellipodium morphogenesis and podosome assembly, paired with signaling pathways (PDGF and Fc receptor signaling, IP3 biosynthesis) that regulate cell movement and morphology, suggesting a cohesive theme of cytoskeletal remodeling coupled to signal transduction.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000394","count":3},{"id":"GO:0060368","count":2},{"id":"GO:1903679","count":2},{"id":"GO:1902951","count":2},{"id":"GO:0032959","count":2}]},{"hash":"451070575058572336","title":"GPCR Signaling and Visual Perception","description":"The terms cluster around GPCR-related signaling (adenylate cyclase activation, cAMP signaling, GTPase regulation, calcium release) and visual/opsin pathways (visual perception, opsin signaling), with some developmental hints; together they point to a coherent theme of signal transduction and vision.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006468","count":2},{"id":"GO:0051281","count":2},{"id":"GO:0007190","count":2},{"id":"GO:0043950","count":2},{"id":"GO:0001975","count":2}]},{"hash":"1224245240456473244","title":"Ubiquitin-like Modifications and Mitophagy","description":"This cluster is driven by GO terms for protein modification by ubiquitin-like systems (neddylation, sumoylation, urmylation) and degradation pathways (ubiquitin-dependent ERAD and mitochondrial autophagy). Although some terms (tRNA thiolation, molybdopterin cofactor biosynthesis) seem less related, the strong representation of ubiquitin-like modifications with mitophagy points to a core theme of protein quality control and turnover.","confidence":"Medium","size":6,"edges":6,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051726","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0002143","count":1},{"id":"GO:0032447","count":1},{"id":"GO:0006777","count":1}]},{"hash":"2008207120378327842","title":"Kidney development and osmoregulation","description":"The terms are dominated by metanephric kidney development (glomerulus vasculature, collecting duct), electrolyte handling (potassium transport), and water homeostasis, with signaling processes (cGMP/cAMP) linked to renal function. Some terms about odontogenesis or brain development appear as broader developmental annotations but do not outweigh the kidney-focused signals. Overall, this cluster reflects a kidney morphogenesis and osmoregulatory module.","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042476","count":1},{"id":"GO:0071474","count":1},{"id":"GO:0071472","count":1},{"id":"GO:0071320","count":1},{"id":"GO:0072239","count":1}]},{"hash":"349721096467552160","title":"RNA processing and translation initiation regulation","description":"The top GO terms cluster around RNA metabolism and control of protein synthesis: mRNA stability, modification, and splicing, as well as formation of the translation preinitiation complex and translation initiation regulation, with regulatory ncRNA-mediated silencing. Some terms are obsolete or peripheral (e.g., viral translation), but the core signal points to RNA processing and translation initiation control. The lack of edges suggests these proteins share functional associations with RNA processing/translation rather than a single multi-protein complex.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010610","count":3},{"id":"GO:0075525","count":2},{"id":"GO:1901407","count":2},{"id":"GO:0006378","count":2},{"id":"GO:1902625","count":2}]},{"hash":"1715124811792278542","title":"Neural development and sensory organ formation","description":"This cluster is dominated by GO terms related to neural development (dendrite development, neuroblast proliferation regulation, cerebellum and metencephalon development) and sensory organ morphogenesis (cochlea morphogenesis, excitatory synaptic activity). The presence of terms about brain regions and synaptic potential suggests a coherent theme of nervous system development and function, with some peripheral noise like liver development as possible annotation artifact. Confidence: High","confidence":"","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016358","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0002087","count":2},{"id":"GO:0021549","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1932987634707109980","title":"Reproductive and Skeletal Development","description":"These proteins show GO terms concentrated in developmental processes, especially reproductive system development (gonadotropin-releasing hormone response, ovarian follicle development, copulation) and skeletal/muscular/craniofacial development (muscle cell development, skeletal system development, roof of mouth development). While a couple of terms are more general or unrelated (e.g., antibacterial response), the dominant themes point to vertebrate development with emphasis on reproductive and skeletal tissues, making this a plausible, cohesive cluster label.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097211","count":1},{"id":"GO:2000354","count":1},{"id":"GO:0048747","count":1},{"id":"GO:0060021","count":1},{"id":"GO:0001501","count":1}]},{"hash":"823667152905409745","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by translation-related terms and ribosome biogenesis (translation; ribosomal small subunit biogenesis; ribosome biogenesis; SSU-rRNA maturation), pointing to roles in assembling and exporting the small ribosomal subunit and in protein synthesis. Some other terms appear only sparsely and may reflect minor or incidental associations rather than core functions.","confidence":"High","size":6,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0042274","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0000462","count":1},{"id":"GO:1905053","count":1}]},{"hash":"967837921992172502","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0071374","count":1},{"id":"GO:1901621","count":1},{"id":"GO:0090084","count":1},{"id":"GO:0006458","count":1}]},{"hash":"148280794107958951","title":"Apoptosis and TNF\u2013NF-\u03baB Signaling","description":"The top GO terms cluster around ubiquitin-dependent protein catabolism, regulation of apoptosis, cytochrome c release from mitochondria, and TNF-mediated signaling with NF-\u03baB activation, pointing to a coherent role in apoptotic control and inflammatory signaling; a single outlier term (V(D)J recombination) does not undermine this theme.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0042981","count":1},{"id":"GO:0090073","count":1},{"id":"GO:2000620","count":1},{"id":"GO:0033151","count":1}]},{"hash":"2071106205119583438","title":"Larval chitin-based cuticle development","description":"The top GO term is larval chitin-based cuticle development (GO:0008363), indicating these proteins are linked to formation/remodeling of the larval exoskeleton made of chitin. The cluster appears cohesive around this developmental process, supporting a label focused on larval cuticle formation.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":5}]},{"hash":"801177243731824089","title":"Insect morphogenesis and ecdysone signaling","description":"This cluster's GO terms point to insect development and tissue morphogenesis (leg and eye-antennal disc morphogenesis, ventral midline development, gonad morphogenesis) plus hormonal control (cellular response to ecdysone, hormone-mediated apoptotic signaling). Together, these relations suggest proteins involved in insect morphogenesis regulated by ecdysone signaling and related hormonal pathways, including imaginal-disc\u2013based development and associated physiological processes.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007478","count":1},{"id":"GO:0007455","count":1},{"id":"GO:0008628","count":1},{"id":"GO:0061040","count":1},{"id":"GO:0048060","count":1}]},{"hash":"2292486617456106140","title":"Insect larval cuticle and lipid metabolism","description":"The GO terms cluster around larval chitin-based cuticle development, paired with multiple lipid-transport and metabolism processes (long-chain fatty acid transport, lysophospholipid transport, beta-oxidation regulation) and oxidative stress responses (hydrogen peroxide, oxidant detoxification) plus hypoxia. This pattern suggests a theme where larval insects coordinate cuticle-related development with lipid handling and detox/stress responses, rather than a single unified process.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0070301","count":1},{"id":"GO:0008206","count":1},{"id":"GO:0015909","count":1},{"id":"GO:0050892","count":1}]},{"hash":"1918005368269702529","title":"Developmental patterning and neuronal differentiation","description":"The terms indicate a neural development focus: neuron differentiation and migration, motor neuron axon guidance, and brain patterning (telencephalon regionalization, hypothalamus, spinal cord). Additional terms cover organogenesis in thyroid, heart (atrioventricular node), and kidney (nephron tubule differentiation), suggesting a broader developmental program. Together, they point to developmental patterning and lineage specification, with a neural emphasis.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021527","count":3},{"id":"GO:0030878","count":3},{"id":"GO:0021978","count":3},{"id":"GO:0009952","count":3},{"id":"GO:2000288","count":3}]},{"hash":"75194847741079397","title":"Embryonic organogenesis","description":"These proteins are linked to development across multiple organs and neural structures (hypothalamus, pituitary, spinal cord, neural crest, inner ear, pancreas, digestive tract, ureteric bud). The GO terms cluster around embryogenesis and organ formation rather than a single pathway, with transcriptional regulation indicating tight developmental control. The common theme is embryonic organ development across diverse tissues, so Embryonic organogenesis.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0021854","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0021521","count":5},{"id":"GO:0031018","count":5},{"id":"GO:0090190","count":5}]},{"hash":"2059437258085976496","title":"Proteostasis and Organelle Maintenance","description":"The top GO terms converge on protein quality control and handling (ERAD, proteasome/ubiquitin pathways, response to misfolded proteins, stress granule dynamics) along with organelle maintenance functions (peroxisomal import, mitochondrial activity and mtDNA regulation), suggesting a cohesive theme of maintaining protein homeostasis across cellular compartments, despite some peripheral processes like vesicle transport and centriole elongation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016558","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0000027","count":1},{"id":"GO:0070682","count":1},{"id":"GO:1903862","count":1}]},{"hash":"2156723018110333628","title":"Nervous system development and morphogenesis","description":"The GO terms point to neuronal function (clustering of voltage-gated potassium channels and transmission of nerve impulse) together with developmental morphogenesis processes (notochord cell development, embryonic body morphogenesis, vestibular receptor cell morphogenesis) and ECM remodeling (collagen fibril organization). While a few terms appear peripheral, the dominant theme centers on neural development and tissue morphogenesis, supporting this label.","confidence":"Medium","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0045163","count":4},{"id":"GO:0043277","count":4},{"id":"GO:0030199","count":4},{"id":"GO:0060035","count":4},{"id":"GO:0010172","count":4}]},{"hash":"909053192784351559","title":"Unknown","description":"No GO terms or interactions are reported for this cluster (no edges, no triangles), and the RECIPE re-additions do not reveal a coherent shared function. Therefore, there is no basis for a specific label.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"420437050699160235","title":"Chromatin Organization and Nucleosome Assembly","description":"Dominant GO terms center on chromatin architecture: nucleosome assembly, heterochromatin organization, rDNA heterochromatin formation, and chromatin localization to chromatin, with some related to nucleus size. These collectively indicate a cluster focused on chromatin structure and its regulation, rather than signaling or metabolic functions.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":5},{"id":"GO:0006334","count":3},{"id":"GO:0016584","count":3},{"id":"GO:0070828","count":3},{"id":"GO:0097298","count":3}]},{"hash":"787275001887915923","title":"Meiotic Nuclear Transport and Spindle Assembly","description":"Top terms cluster around meiotic nuclear division, meiotic spindle elongation, nuclear pore complex assembly, and NLS-bearing protein import into the nucleus, pointing to a cohesive role in meiotic chromosome segregation via nuclear transport and spindle dynamics. Supporting terms like TORC1 signaling and GTPase regulation may reflect broader cell-cycle control during meiosis, but the dominant theme is meiosis-associated nuclear transport and spindle function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0000060","count":1},{"id":"GO:0006672","count":1},{"id":"GO:0000188","count":1}]},{"hash":"2028944369681971365","title":"Actin Dynamics and Endocytosis Regulation","description":"Based on the enriched GO terms, the cluster centers on actin cytoskeleton remodeling (actin filament organization, Arp2/3-mediated actin nucleation) and membrane trafficking processes (regulation of endocytosis, pinocytosis), with additional hints of protein turnover (ubiquitination) and apoptosis. The dominant theme is dynamic actin remodeling coupled to endocytic/membrane trafficking, though a few outlier terms suggest broader regulatory roles.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0030476","count":1},{"id":"GO:0050731","count":1},{"id":"GO:0007015","count":1}]},{"hash":"91426264157938494","title":"Oxidative metabolism and stress responses","description":"This cluster centers on redox-related processes and contexts that involve oxidation and metabolism (oxidation-reduction, omega-oxidation of fatty acids, lignin biosynthetic pathways linked to oxidative phenylpropanoid metabolism) and on cellular responses to chemical stress (response to copper ions, response to antineoplastic agents). The mix of metabolic and stress-response GO terms suggests a theme around oxidative metabolism tied to environmental/chemical challenges, despite some broader terms like respiratory system process that reflect general energy metabolism.","confidence":"Medium","size":6,"edges":9,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0042572","count":4},{"id":"GO:0097327","count":2},{"id":"GO:0009809","count":2},{"id":"GO:0010430","count":2}]},{"hash":"2122685398120765994","title":"Neural sensory processing and dopaminergic signaling","description":"The terms cluster around neural signaling: sensory perception (vision and pain), dopaminergic synaptic transmission, cocaine-related behavioral responses, and ERK-driven plasticity, with prostaglandin responses also present. Developmental terms are less central, suggesting a coherent theme of neural sensory processing and dopamine signaling.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0071380","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0007601","count":6},{"id":"GO:0008542","count":6}]},{"hash":"741362813063283009","title":"Proteasome-Dependent Regulation of Differentiation","description":"The cluster\u2019s strongest signals come from ubiquitin-proteasome\u2013mediated protein catabolism, including positive regulation of proteasomal ubiquitin-dependent degradation and general ubiquitin-dependent proteolysis, alongside terms for stem cell and neuron differentiation and proliferation. This suggests a shared theme where proteostasis influences differentiation and cell fate decisions. Other terms related to translation initiation and DNA repair appear, but do not contradict the dominant proteostasis-and-differentiation theme. Overall, the name captures the most representative function driving this cluster.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032436","count":2},{"id":"GO:0048863","count":2},{"id":"GO:0043248","count":1},{"id":"GO:0075525","count":1},{"id":"GO:0008283","count":1}]},{"hash":"2064461007474991372","title":"Protein quality control and mitochondrial maintenance","description":"The Top Terms center on proteostasis-related processes (proteasome regulatory particle assembly, cellular response to misfolded protein, stress granule disassembly, SNARE complex disassembly, protein processing) alongside mitochondrial functions (positive regulation of oxidative phosphorylation, regulation of mitochondrial DNA replication) and cell cycle-related processes (centriole elongation, cell division). This suggests a theme of coordinating protein quality control with mitochondrial energy metabolism and cell-cycle progression.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070682","count":4},{"id":"GO:1903862","count":4},{"id":"GO:0071218","count":4},{"id":"GO:0090296","count":4},{"id":"GO:1903724","count":4}]},{"hash":"1618707645068029350","title":"Ubiquitin-regulated immune signaling","description":"The top terms cluster around ubiquitination control (negative regulation of protein ubiquitination, ubiquitin-dependent protein catabolic process, K33-linked ubiquitination) and immune-related processes (mast cell cytokine production, dendritic cell differentiation, IgE isotype regulation), suggesting a group of proteins that regulate ubiquitin-mediated turnover to modulate immune signaling and differentiation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":5},{"id":"GO:0032764","count":4},{"id":"GO:0042787","count":4},{"id":"GO:2000312","count":4},{"id":"GO:1904431","count":4}]},{"hash":"1107435322992106399","title":"Chitin-based cuticle development and ecdysis","description":"The top GO terms are dominated by chitin-related processes (chitin catabolic process, chitin-based cuticle development, ecdysis) and related polysaccharide catabolism, which together point to insect/arthropod exoskeleton formation and molting. Some immune signaling terms (NF-kappaB activation, interleukin responses) may be annotations from broader or cross-species data and appear secondary. Despite no network edges, the GO profile supports a cohesive theme centered on cuticle formation and molting.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006032","count":3},{"id":"GO:0007250","count":3},{"id":"GO:0030324","count":3},{"id":"GO:0071347","count":3},{"id":"GO:0000272","count":3}]},{"hash":"1123303567007351688","title":"Small-molecule membrane transport","description":"The terms show transmembrane transport of glucose, myo-inositol, biotin, pantothenate, and sodium ions, with an additional acetylcholine biosynthetic process. The common theme is membrane-associated handling of diverse small molecules, suggesting a cluster of transporters or transport-related enzymes for metabolic substrates. ","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":1},{"id":"GO:0015798","count":1},{"id":"GO:0071436","count":1},{"id":"GO:0008292","count":1},{"id":"GO:0015878","count":1}]},{"hash":"657822335647402540","title":"Embryonic tissue morphogenesis","description":"The GO terms center on embryonic development and morphogenesis across multiple tissues (limb, spinal cord, retina, mesoderm, spleen, muscle), indicating a broad theme of organogenesis during embryogenesis rather than a single pathway. A cell-cycle term is present but does not alter the overall developmental focus. ","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0010971","count":1},{"id":"GO:0030326","count":1},{"id":"GO:0007585","count":1},{"id":"GO:0021516","count":1},{"id":"GO:0035162","count":1}]},{"hash":"1194071277582113133","title":"ER\u2013Golgi Vesicle Transport","description":"The top GO terms cluster around trafficking between the endoplasmic reticulum and the Golgi, including ER-to-Golgi vesicle transport, COPII coat regulation, and Golgi-to-plasma membrane protein transport, with tubulin complex assembly supporting microtubule-based vesicle movement. Positive regulation of ER-to-Golgi transport reinforces the central theme. Some terms (tight junction assembly, myeloid apoptotic process, copper ion homeostasis, cell cycle) appear less directly related, likely reflecting broader cellular processes or noise, but the core signal points to vesicle trafficking machinery and its regulation.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0003400","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0043001","count":3},{"id":"GO:0007049","count":3}]},{"hash":"1341867613930574159","title":"Plant carbon metabolism and biosynthesis","description":"The top GO terms cluster around central metabolism: photorespiration, glycolate and related carbon pathways, ammonia assimilation, and biosynthesis of nucleotides (GTP, GMP) and amino acids (glutamate). Several terms are plant-specific (photorespiration, oxidative photosynthetic carbon pathway), suggesting these proteins participate in plant primary metabolism and carbon/nitrogen assimilation. The occasional mention of protein homotetramerization may reflect enzyme complexes or multimeric regulation within these pathways. Overall, a coherent theme of plant carbon metabolism and biosynthesis emerges, albeit with some breadth.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0018924","count":1},{"id":"GO:0006183","count":1},{"id":"GO:0097054","count":1},{"id":"GO:0009853","count":1}]},{"hash":"444387409474215638","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0071374","count":2},{"id":"GO:1901621","count":2},{"id":"GO:0090084","count":2}]},{"hash":"2061686923628974048","title":"Chordate Heart and Pharyngeal Development","description":"Most of the top GO terms point to heart-related processes (sinoatrial node development, cardioblast differentiation, blood circulation) and pharyngeal/muscle development in chordates, suggesting a cohesive theme of cardiovascular and pharyngeal morphogenesis. Some terms appear unrelated (e.g., conditioned taste aversion, interferon production), but the core signal is heart and pharyngeal development.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001661","count":2},{"id":"GO:0014028","count":1},{"id":"GO:0032609","count":1},{"id":"GO:0060465","count":1},{"id":"GO:0060931","count":1}]},{"hash":"1210112938901368701","title":"Insect innate immune signaling","description":"The terms are dominated by innate immune pathways: Toll signaling, response to dsRNA, and regulation of NOD-like receptor signaling, all pointing to antiviral/inflammatory signaling in insects. The presence of ubiquitination-related regulation further supports immune signaling modulation rather than a single metabolic function. A chitin-based cuticle development term appears, likely representing arthropod biology noise rather than a core cluster function.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0010804","count":1},{"id":"GO:0070434","count":1},{"id":"GO:0042130","count":1},{"id":"GO:0043331","count":1}]},{"hash":"676405925934802954","title":"Ubiquitin-Dependent Protein Degradation","description":"This cluster is dominated by GO terms tied to ubiquitination and proteasomal degradation, including ubiquitin-dependent protein catabolic process, ERAD, and K48-linked ubiquitination, indicating a core role in tagging and removing proteins. Additional terms like Wnt receptor catabolic process and negative regulation of organ growth fit within the umbrella of regulated turnover of signaling components, though peroxisome import is a less central association. Overall, the common theme is ubiquitin-mediated protein turnover.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0030433","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0038018","count":3}]},{"hash":"314031605374746285","title":"Organelle-specific autophagy under nutrient stress","description":"The GO terms cluster around autophagic processes targeting various organelles (mitochondria, ER, and nucleus) and a general cellular response to amino acid starvation and iron, indicating autophagy-driven turnover of cellular components under stress. Membrane remodeling terms (phospholipid and inositol biosynthesis) support autophagy-related membrane dynamics, while some terms may be incidental noise. Overall, the dominant theme is organelle-specific autophagy under nutrient/stress conditions.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008654","count":1},{"id":"GO:0006021","count":1},{"id":"GO:0000226","count":1},{"id":"GO:0035096","count":1},{"id":"GO:0034198","count":1}]},{"hash":"1694923967402362312","title":"Unknown","description":"The terms are highly diverse (telomere regulation, epithelial polarity, proteasome assembly, cold response, chemokine production, Wnt signaling, cardiac action potential, NOD2 signaling, and foam cell differentiation) with no evident shared pathway or interaction; plus no edges connect the proteins. This suggests no cohesive functional theme for the cluster.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904357","count":1},{"id":"GO:0090162","count":1},{"id":"GO:0070682","count":1},{"id":"GO:0009409","count":1},{"id":"GO:0071651","count":1}]},{"hash":"1941670149993073153","title":"Plant meiosis and seed development","description":"This cluster is dominated by meiotic processes (meiotic DSB formation, double-strand break repair in meiotic recombination, reciprocal recombination, chiasma assembly) and plant reproductive development terms (embryo sac development, seed development), suggesting a cohesive theme of meiosis coupled to seed formation. A related term on proteasomal degradation may reflect regulatory protein turnover during meiosis.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032435","count":2},{"id":"GO:0009553","count":1},{"id":"GO:0051026","count":1},{"id":"GO:0042138","count":1},{"id":"GO:0007131","count":1}]},{"hash":"529673403697111976","title":"Immune signaling and antigen presentation","description":"The top GO terms cluster around immune signaling and antigen processing/presentation, including non-canonical NF-kappaB signaling, TNF-mediated signaling, and MHC class I antigen presentation. While a few terms touch on cell cycle or ubiquitin regulation, the dominant theme is immune response signaling and antigen presentation, suggesting this cluster represents immune-related pathways.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0061418","count":2},{"id":"GO:0038061","count":2},{"id":"GO:0010950","count":2},{"id":"GO:0031145","count":2},{"id":"GO:0002223","count":2}]},{"hash":"1224071860195645379","title":"Unknown","description":"The top GO terms are highly diverse (oxidation\u2013reduction, cholangiocyte proliferation, mitotic checkpoint signaling, ion channel regulation, isotype switching, Purkinje cell organization, Rap signaling, transcriptional regulation, NF-kappaB signaling, and miRNA processing) with no single shared function or pathway. There are no edges or triangles linking the proteins, and the mix suggests a random or heterogeneous cluster rather than a coherent biological function, so a specific label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:1990705","count":1},{"id":"GO:0044810","count":1},{"id":"GO:1905150","count":1},{"id":"GO:0045190","count":1}]},{"hash":"1912701164820144752","title":"Multiorgan Developmental Signaling","description":"The cluster is dominated by GO terms tied to development across multiple organs (nervous system, hippocampus, kidney, heart) and by signaling pathways like Smoothened and Roundabout, suggesting proteins involved in broad developmental signaling networks rather than a single tissue. An immune signaling term (T cell receptor signaling) appears as an outlier but does not override the overall developmental-signaling theme.","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043525","count":3},{"id":"GO:0021766","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0001822","count":3}]},{"hash":"500175606605456276","title":"Plant Defense and Detoxification Responses","description":"The GO terms predominantly reflect defense and detox responses (lipopolysaccharide, xenobiotic, copper ion, and antineoplastic agent responses) with lignin biosynthesis for cell-wall reinforcement, plus related metabolism (fatty acid oxidation) and signaling regulation, suggesting a cohesive theme of plant stress defense and detoxification rather than a single specific pathway.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":4},{"id":"GO:2000648","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0097327","count":2},{"id":"GO:0009809","count":2}]},{"hash":"147561477899367401","title":"Neural development and neurotransmitter signaling","description":"This cluster's GO terms cluster around neural development and neuroendocrine processes: pituitary gland development, neuron maturation, and neural precursor proliferation. Additional terms for dopamine catabolic process and cellular response to cAMP point to signaling and neurotransmitter regulation in neural cells. While other terms (response to xenobiotic stimulus, selenium ion) are broader stress-related responses, the dominant signal is neural development and signaling.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0042551","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0071320","count":2}]},{"hash":"75402724621931993","title":"Ubiquitin-Proteasome System","description":"This cluster is dominated by GO terms tied to the ubiquitin-proteasome pathway, including K11-linked ubiquitination, polyubiquitination, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, and proteasome regulatory particle assembly. These terms point to a shared function in tagging and degrading proteins via the proteasome, a central mechanism influencing cell cycle progression, synaptic plasticity, and various cellular organization processes represented among the terms.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070979","count":2},{"id":"GO:0031915","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0008283","count":2}]},{"hash":"1828401762638470329","title":"Renal hormone signaling and urine homeostasis","description":"GO terms emphasize kidney collecting duct development, urine volume regulation, potassium transport, and endocrine responses (thyroid/steroid hormones), suggesting a renal endocrine control of fluid and ion homeostasis with cell survival signaling.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051897","count":3},{"id":"GO:0072061","count":3},{"id":"GO:0071799","count":3},{"id":"GO:0035809","count":3},{"id":"GO:1900053","count":3}]},{"hash":"1305825076798655066","title":"Ribosome maturation and translation control","description":"The cluster is dominated by GO terms related to translation and ribosome RNA processing (translation, maturation of 5.8S and LSU rRNA), and regulation of cap-independent translational initiation, pointing to ribosome biogenesis and control of protein synthesis. A few low-frequency terms about mRNA stability and miscellaneous immune/viral interactions exist but do not define the main function. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903679","count":1},{"id":"GO:0044829","count":1},{"id":"GO:0043488","count":1},{"id":"GO:0034052","count":1},{"id":"GO:1900363","count":1}]},{"hash":"113058929345462141","title":"RNA processing and post-transcriptional regulation","description":"The cluster shows multiple GO terms centered on RNA metabolism and post-transcriptional control, including regulation of RNA Pol II CTD phosphorylation, mRNA polyadenylation, RNA export, and mRNA modification, as well as ncRNA-mediated gene silencing and ubiquitin-related deubiquitination. These collectively indicate a shared function in RNA processing and regulation of gene expression after transcription. A single term about larval cuticle development appears as an outlier, and several entries are marked obsolete, but the dominant signal is RNA-centric regulation.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0075525","count":1},{"id":"GO:1901407","count":1},{"id":"GO:0006378","count":1},{"id":"GO:0046832","count":1}]},{"hash":"1778724017543247249","title":"mRNA processing and translation initiation control","description":"The top GO terms link RNA processing and mRNA maturation (splicing, export) with translation initiation and reinitiation (including viral IRES-dependent initiation), suggesting a functional cluster of proteins that coordinate mRNA maturation with the control of translation.","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0075525","count":2},{"id":"GO:0006396","count":2},{"id":"GO:0006446","count":2}]},{"hash":"973741037637452351","title":"Nuclear transport and pore complex dynamics","description":"This cluster centers on proteins involved in nuclear import/export, nuclear envelope dynamics, and nuclear pore organization (e.g., import via NLS, tRNA export, NPC assembly, and mitotic nuclear membrane disassembly). The presence of protein oligomerization terms supports assembly of transport machinery, and the viral intracellular transport term aligns with nuclear-cytoplasmic trafficking. Overall, the GO terms converge on nuclear transport and envelope/pore dynamics.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007077","count":4},{"id":"GO:0042306","count":4},{"id":"GO:0010827","count":4},{"id":"GO:0075733","count":4},{"id":"GO:0006409","count":4}]},{"hash":"1824696406246705657","title":"Organ Development and Ion Homeostasis","description":"These proteins show enrichment across multiple organ development terms (kidney, distal tubule, hindlimb, trigeminal nerve, inferior colliculus) and include ion homeostasis terms (sodium, ammonium), suggesting a cluster of factors involved in organogenesis with ancillary roles in ionic balance and neural development.","confidence":"Medium","size":5,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0072017","count":2},{"id":"GO:0070172","count":2},{"id":"GO:0021559","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0043525","count":2}]},{"hash":"1212396526022573397","title":"Vesicle trafficking and Golgi targeting","description":"This cluster is dominated by GO terms related to intracellular trafficking and vesicle formation, such as protein targeting to the vacuole, protein localization to the Golgi apparatus, COPII vesicle coating regulation, and synaptic vesicle budding. These consistently point to a shared role in trafficking between ER, Golgi, and lysosome/vacuole compartments. While a few terms touch on development or cell cycle, the strongest signal centers on vesicle transport and Golgi/vacuolar targeting. Confidence: High","confidence":"","size":5,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006623","count":2},{"id":"GO:0070142","count":2},{"id":"GO:0000042","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0010513","count":2}]},{"hash":"1707089429576962103","title":"Neurodevelopment and Embryonic Morphogenesis","description":"The top GO terms coalesce around nervous system development and embryonic body formation, including notochord development, embryonic morphogenesis, vestibular receptor morphogenesis, and transmission of nerve impulses, with supporting ECM remodeling via collagen fibril organization. The voltage-gated potassium channel clustering aligns with neuronal differentiation, tying the cluster to neurodevelopmental processes; a few terms (e.g., ovulation cycle) appear peripheral. Overall, the dominant theme is neurodevelopment and embryonic morphogenesis.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045163","count":5},{"id":"GO:0043277","count":5},{"id":"GO:0030199","count":5},{"id":"GO:0060035","count":5},{"id":"GO:0010172","count":5}]},{"hash":"1392879506349138712","title":"Neural development and axon guidance signaling","description":"This cluster is enriched for GO terms tied to nervous system development, axon guidance, and Robo/roundabout signaling, with supporting hints from Hedgehog Smoothened signaling and ERK cascade regulation. While a few terms touch on broader organ development (kidney, bone), the dominant theme among the proteins appears to be neural development and pathfinding.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043552","count":5},{"id":"GO:0043931","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0001822","count":5},{"id":"GO:0007224","count":5}]},{"hash":"1622547193195355975","title":"Unknown","description":"The terms are highly heterogeneous, including cell division, ribosome biogenesis, transcription regulation, differentiation in prostate epithelium, sporulation, and various transmembrane transports and reproductive processes. There\u2019s no clear shared function or theme linking these proteins, and no interaction structure to support a cohesive cluster function. Therefore, assign Unknown with None.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0060528","count":2},{"id":"GO:0030435","count":1}]},{"hash":"167939123857911253","title":"Proteostasis and ER-Golgi trafficking","description":"The terms center on ER stress response (UPR), protein processing and retention in Golgi, proteasome assembly, and vesicle formation, indicating a cluster enriched for proteostasis and trafficking functions. Some terms are ancillary housekeeping processes, but the dominant theme is protein quality control and secretory-pathway management.","confidence":"Medium","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045899","count":3},{"id":"GO:0090261","count":3},{"id":"GO:0070676","count":3},{"id":"GO:2001171","count":3},{"id":"GO:0051013","count":3}]},{"hash":"1622315577286748625","title":"Developmental signaling and cytoskeletal regulation","description":"These terms center on development and growth (multicellular growth, forebrain development, TGF-beta response) and cytoskeletal remodeling (Arp2/3 actin nucleation, mitotic spindle assembly), plus gene expression/modification regulation (histone acetylation, ubiquitination) that supports developmental programs.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":2},{"id":"GO:0043981","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0030900","count":2}]},{"hash":"1981010932916840480","title":"DNA Transposition Proteins","description":"The top GO terms are dominated by DNA integration and DNA transposition, consistent with a cluster of transposase-like or DNA mobility factors. The other terms (thyroid development, MAPK pheromone response, PDGF stimulus, ephrin signaling, brown fat differentiation, planar polarity) appear incidental or reflect multifunctionality, but they do not cohere around a single shared function beyond transposition.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0006313","count":3},{"id":"GO:0030878","count":1},{"id":"GO:0071507","count":1},{"id":"GO:0036120","count":1}]},{"hash":"760012602811428428","title":"Mycothiol/Bacillithiol Biosynthesis and Detoxification","description":"The cluster is dominated by GO terms for mycothiol and bacillithiol biosynthesis and mycothiol-dependent detoxification, backed by a xenobiotic response term, pointing to a cohesive theme of thiol-based redox metabolism and detoxification in Gram-positive bacteria. Some additional terms seem peripheral to this core function.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010125","count":1},{"id":"GO:0071793","count":1},{"id":"GO:0006044","count":1},{"id":"GO:0019396","count":1},{"id":"GO:0010127","count":1}]},{"hash":"124355660172793501","title":"Neuroinflammation and glial activation","description":"This cluster is dominated by terms tied to inflammatory cytokine production (IL-1\u03b2, IL-18) and immune signaling in neural contexts (cellular response to type II interferon, regulation of glial differentiation), pointing to neuroimmune activity. Some other terms reflect general intracellular processes (e.g., microtubule depolymerization, ER membrane fusion) that are less specific to a single function, but the prominent cytokine and glial-related terms suggest a cohesive theme of neuroinflammatory signaling. Given the mixed signals and small protein set, the label captures the strongest shared signal without overclaiming specificity.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034209","count":1},{"id":"GO:1901089","count":1},{"id":"GO:0008582","count":1},{"id":"GO:0071346","count":1},{"id":"GO:0072616","count":1}]},{"hash":"2089199330649127065","title":"Developmental Regulation and Transcription","description":"This cluster is dominated by developmental processes\u2014skeletal system development, neural tube closure, forebrain development, and multicellular organism development\u2014with supporting signals of transcriptional control (DNA-templated transcription) and cell proliferation (mitotic cell cycle). Although immune/ER-stress\u2013related terms appear (defense response to Gram-positive bacterium, intrinsic apoptotic signaling), the central theme ties to developmental transcription programs shaping embryonic growth and organ formation.","confidence":"Medium","size":5,"edges":6,"triangles":2,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001501","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0006349","count":3},{"id":"GO:0001843","count":3}]},{"hash":"1024435134782290703","title":"Ciliary motility and microtubule transport","description":"This cluster is dominated by GO terms tied to cilium/flagellum movement, dynein arm assembly, and microtubule-based transport (including intraciliary retrograde transport and minus-end-directed vesicle movement), as well as left/right symmetry determination and spindle localization. Together these point to a coherent theme of ciliary motility and associated microtubule-based transport processes, with developmental left-right patterning as a related readout. Some terms like stress granule assembly are tangential but do not override the core ciliary/microtubule theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036159","count":1},{"id":"GO:0003341","count":1},{"id":"GO:0030317","count":1},{"id":"GO:0034063","count":1},{"id":"GO:0007018","count":1}]},{"hash":"1530027730042615065","title":"GCN2-driven Translational Stress Response","description":"This cluster centers on regulation of translation under stress, highlighted by GO terms for eIF2\u03b1 phosphorylation in ER stress, GCN2-mediated signaling, and regulation of translation in response to amino acid starvation and UV-induced stress. The mix of translation control and stress signaling terms (including cytoplasmic translation regulation and DNA damage signaling) supports a cohesive theme of stress-responsive translational regulation, rather than a single metabolic pathway.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031953","count":1},{"id":"GO:0036492","count":1},{"id":"GO:0031333","count":1},{"id":"GO:0072755","count":1},{"id":"GO:1903833","count":1}]},{"hash":"1666588687786031988","title":"GTPase-regulated cytoskeleton and vascular permeability regulators","description":"The top terms point to regulation of small GTPase activity and actin cytoskeleton organization, coupled with control of vascular permeability, neutrophil degranulation, and cell extravasation. This suggests a group of proteins that modulate endothelial barrier function and immune cell trafficking through GTPase signaling and cytoskeletal remodeling, with a potential secondary link to growth hormone receptor signaling. Overall, a cohesive theme of GTPase-driven cytoskeletal regulation influencing vascular and immune processes.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0043114","count":2},{"id":"GO:0043314","count":2},{"id":"GO:0060313","count":2},{"id":"GO:0060396","count":2}]},{"hash":"2266373016044483177","title":"Plant hormone biosynthesis and fruit ripening","description":"This cluster is driven by GO terms for multiple plant hormones (gibberellin, ethylene, auxin, salicylic acid) and processes related to fruit ripening, hormone metabolism, and stress responses (including hydrogen peroxide\u2013mediated programmed cell death). While there are a few outliers related to secondary metabolite biosynthesis, the dominant theme ties hormone biosynthesis to developmental outcomes like ripening.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902835","count":2},{"id":"GO:0010023","count":2},{"id":"GO:0009686","count":2},{"id":"GO:0009852","count":2},{"id":"GO:0010421","count":2}]},{"hash":"89746983096419479","title":"Neural morphogenesis and ECM remodeling","description":"The cluster\u2019s terms are dominated by neural and sensory tissue development (axonal fasciculation, regulation of branching morphogenesis of a nerve, otolith morphogenesis) and extracellular matrix organization (collagen fibril organization and its negative regulation), suggesting a theme of tissue morphogenesis with ECM remodeling. While there is one immune signaling term (MyD88-dependent TLR), the strongest signal centers on developmental and neural patterning processes.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060011","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0051770","count":2},{"id":"GO:0002755","count":2},{"id":"GO:1904027","count":2}]},{"hash":"839033048865809275","title":"Embryonic organogenesis and patterning","description":"Top GO terms center on developmental processes across multiple organs (cartilage morphogenesis, left/right patterning, placenta and endocrine development, heart structures via EMT and cardiac fate regulation). This points to a shared theme of embryonic organ development and tissue differentiation rather than a single function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":1},{"id":"GO:0060972","count":1},{"id":"GO:0060707","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0060806","count":1}]},{"hash":"1665386724740267075","title":"Apoptosis and innate immune signaling","description":"The cluster shows strong representation of apoptotic process (GO:0006915), innate immune response (GO:0045087), and pyroptotic inflammatory response (GO:0070269), along with ubiquitination (GO:0016567), suggesting a group of proteins involved in programmed cell death regulation and inflammatory/immune signaling. Some terms like mitotic spindle assembly and telomere maintenance are present but less central, so the core theme remains apoptosis/innate immunity and its regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990001","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0070269","count":2},{"id":"GO:0006915","count":2}]},{"hash":"2237397156317564207","title":"Selenocysteine incorporation during translation","description":"This cluster centers on selenocysteine biology in protein synthesis, driven by GO terms for selenocysteine incorporation, Sec-tRNA(Sec) biosynthesis, and translation. The repeated terms indicate a cohesive Sec incorporation/translational machinery, with only a few unrelated annotations appearing at low frequency.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097056","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0001514","count":2},{"id":"GO:0016259","count":2},{"id":"GO:0071952","count":2}]},{"hash":"913962809601230535","title":"Embryonic heart and craniofacial morphogenesis","description":"The top terms point to embryonic development and tissue shaping, with strong emphasis on heart development (GO:0007507) and embryonic cranial skeleton morphogenesis (GO:0048701), plus organ induction and multicellular organism development. Additional related terms like neuron migration and cell adhesion support a broader developmental morphogenesis theme, while the complement activation term appears as an outlier. Overall, this cluster seems centered on embryonic development with a focus on cardiac and craniofacial morphogenesis.","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001764","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0048701","count":3},{"id":"GO:0003350","count":3},{"id":"GO:0001759","count":3}]},{"hash":"604800460453185671","title":"Macrophage differentiation and Eph receptor signaling","description":"Based on the Top Terms, the cluster is centered on immune cell development (macrophage differentiation) and membrane-associated cell signaling (ephrin receptor signaling). The presence of membrane transport and GTPase regulation terms supports a theme of signaling and trafficking at the cell surface, around macrophage maturation. However, several other terms (development, ER stress regulation) suggest additional roles, so the connection is plausible but not perfectly cohesive.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030225","count":4},{"id":"GO:0001998","count":3},{"id":"GO:0071806","count":3},{"id":"GO:0048013","count":3},{"id":"GO:0034260","count":3}]},{"hash":"131703518655008341","title":"Microbial Metabolism and Biosynthesis","description":"The top GO terms include thiamine biosynthetic process, antibiotic biosynthetic process, and various amino acid catabolic processes, paired with redox homeostasis and membrane potential regulation, plus a tRNA wobble uridine modification term. This suggests a cluster of enzymes involved in diverse microbial metabolic pathways\u2014biosynthesis, catabolism, and related redox/gene-expression aspects\u2014rather than a single, cohesive pathway. The absence of edges reinforces that these proteins are not tightly connected functionally, further supporting a broad metabolic theme rather than a specific complex. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009228","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0009083","count":1},{"id":"GO:0042853","count":1}]},{"hash":"1937450480400200830","title":"Renal ion transport and kidney development","description":"This cluster centers on electrolyte handling (chloride and bicarbonate transport, pH response) and kidney-related processes (kidney development, epithelial morphogenesis), plus signals tied to renal physiology (cellular response to fluid shear stress and angiotensin signaling). While a couple terms (bone resorption, non-canonical NF-kappaB regulation) are less kidney-specific, the dominant themes point to renal epithelial ion transport and development.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901224","count":2},{"id":"GO:0045780","count":1},{"id":"GO:0055064","count":1},{"id":"GO:0015701","count":1},{"id":"GO:0001822","count":1}]},{"hash":"300599812371178211","title":"Developmental Differentiation Signaling","description":"The top GO terms point to tissue development and differentiation across multiple organs (thyroid gland, bronchus, cerebral cortex) and adipose tissue (brown fat), with emphasis on growth factor signaling pathways (growth hormone receptor signaling, PDGF, MAPK). This suggests a cohesive theme of developmental differentiation regulated by signaling rather than a single pathway, though the connections are broad.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060396","count":2},{"id":"GO:0060434","count":2},{"id":"GO:0021819","count":2},{"id":"GO:0032436","count":2},{"id":"GO:1901621","count":2}]},{"hash":"1400424634385966078","title":"Embryonic neural development and morphogenesis","description":"The proteins appear enriched in embryonic development and tissue morphogenesis (notochord development, embryonic body morphogenesis, vestibular receptor morphogenesis, collagen fibril organization) and also neural function (transmission of nerve impulse, clustering of voltage-gated potassium channels). This combination suggests roles in early nervous system and tissue formation rather than a single structural or metabolic function, justifying a label centered on embryonic neural development and morphogenesis.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045163","count":5},{"id":"GO:0043277","count":5},{"id":"GO:0030199","count":5},{"id":"GO:0060035","count":5},{"id":"GO:0010172","count":5}]},{"hash":"1592882937478878961","title":"Ubiquitin-Dependent Protein Regulation","description":"The cluster shows two clear ubiquitination-related terms (ubiquitin-dependent protein catabolic process and K33-linked ubiquitination), indicating proteins involved in ubiquitin-mediated regulation; other terms touch development and immune signaling, suggesting a broader role in regulated turnover and signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032764","count":4},{"id":"GO:0042787","count":4},{"id":"GO:2000312","count":4},{"id":"GO:0035270","count":4},{"id":"GO:1904431","count":4}]},{"hash":"2039701709475957712","title":"Transmembrane Small Molecule Transporters","description":"The cluster is characterized by GO terms representing transmembrane transport of sugars (glucose, myo-inositol) and vitamins (biotin, pantothenate) as well as sodium ion export, pointing to a set of membrane transport proteins handling uptake/export of small metabolites. A few low-count terms (morphogenesis, proteasome assembly, stress responses) are likely incidental and do not define the core function. ","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":3},{"id":"GO:0015798","count":3},{"id":"GO:0071436","count":3},{"id":"GO:0008292","count":3},{"id":"GO:0015878","count":3}]},{"hash":"2065207211397157332","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006310","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0050909","count":1},{"id":"GO:0000480","count":1}]},{"hash":"136571379150687583","title":"Ubiquitin Deubiquitination and Proteolysis","description":"The terms cluster around ubiquitin-dependent protein catabolic processes and deubiquitination activities (including specific linkages like K11 and K29), plus ubiquitin recycling and ERAD-related references, suggesting a group of proteins involved in the ubiquitin-proteasome system and ER-associated degradation. Some entries are obsolete, but the overall theme remains coherent.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035616","count":1},{"id":"GO:0010992","count":1},{"id":"GO:1990108","count":1},{"id":"GO:0006511","count":1},{"id":"GO:1904378","count":1}]},{"hash":"406902494671226600","title":"TLR and NLR innate immune signaling","description":"The top GO terms point to innate immune sensing pathways, notably MyD88-dependent Toll-like receptor signaling and NOD-like receptor signaling, including detection of bacterial lipopeptides. While a few terms are less relevant or obsolete, the prevailing pattern is microbial recognition and downstream inflammatory signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051770","count":4},{"id":"GO:0002755","count":4},{"id":"GO:0043086","count":4},{"id":"GO:2000172","count":4},{"id":"GO:1905279","count":4}]},{"hash":"453673690285477784","title":"Developmental and Immune Signaling","description":"The top GO terms point to multicellular development (organogenesis, planar polarity, nervous system development, ear morphogenesis) alongside immune-related signaling (dendritic cell cytokine production, B cell receptor signaling, STAT phosphorylation). This mix suggests proteins involved in broad developmental processes with accompanying immune signaling roles rather than a single tight pathway. The lack of interactions supports a high-level functional grouping.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0043552","count":2},{"id":"GO:0001736","count":2},{"id":"GO:0002371","count":2},{"id":"GO:0045425","count":2}]},{"hash":"104477360485072373","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050909","count":1},{"id":"GO:0000480","count":1},{"id":"GO:0001403","count":1},{"id":"GO:2001235","count":1},{"id":"GO:0010659","count":1}]},{"hash":"557925680007509811","title":"Proteostasis and stress response","description":"Top GO terms point to protein quality control (unfolded protein response/ERAD maintenance, protein deglycosylation, translation) and cellular responses to toxins, indicating a theme of proteostasis and general stress management. Some terms appear yeast-specific (spindle pole body duplication, conjugation-associated morphogenesis) or unrelated to a single pathway, suggesting cluster heterogeneity. Overall, the strongest common thread is proteostasis and stress response rather than a specific functional module.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0017085","count":3},{"id":"GO:1900186","count":3},{"id":"GO:0030474","count":3},{"id":"GO:0000753","count":3},{"id":"GO:1904378","count":3}]},{"hash":"1614879178015330604","title":"Neuronal development and signaling","description":"The GO terms cluster around neuronal development and signaling: neuron migration, planar cell polarity components, Rho signaling, and responses related to neural activity (cocaine). Activation of kinase activity supports broader signaling cascades, while ribosome biogenesis suggests general protein synthesis during development. Together they point to neurons coordinating growth and movement through signaling and polarity pathways.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0032147","count":2},{"id":"GO:0090179","count":1},{"id":"GO:0060732","count":1},{"id":"GO:0035025","count":1}]},{"hash":"192234475898519345","title":"Wing Disc Morphogenesis and Epithelial Polarity","description":"The GO terms show a clear emphasis on wing disc development (morphogenesis) and epithelial cell polarity, including basolateral membrane localization, aligning with Drosophila imaginal wing disc biology. Related signaling (TOR, cAMP, and general signal transduction) supports growth and polarity establishment, while some terms reflect broader cellular processes but do not outweigh the core morphogenesis/polarity theme.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007472","count":1},{"id":"GO:0009966","count":1},{"id":"GO:0045943","count":1},{"id":"GO:1903361","count":1},{"id":"GO:0035308","count":1}]},{"hash":"1133335060575009773","title":"Unknown","description":"No GO terms are listed for this cluster, and with only 3 edges among 4 proteins (max degree 2), there is no clear shared function to base a label on.","confidence":"","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"356461175661525237","title":"Cardiac Muscle Stress Signaling","description":"This cluster centers on mechanical stretch responses in muscle and signaling pathways (Wnt, TGF-beta) involved in cardiac remodeling and proliferation control, with supporting signals for apoptosis and cell migration. Telomere-related terms may reflect broader cellular stress responses. Overall, the terms align with cardiac muscle stress signaling and remodeling.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035994","count":3},{"id":"GO:0046827","count":2},{"id":"GO:0030512","count":2},{"id":"GO:0090263","count":2},{"id":"GO:1904355","count":2}]},{"hash":"1343093109767895498","title":"Embryonic development and organogenesis","description":"These proteins appear linked to broad developmental processes across tissues and organs: cartilage morphogenesis, left/right patterning, placenta/embryonic placental differentiation, endocrine system development, heart-associated epithelial-to-mesenchymal transitions, pancreatic development, and neuron differentiation. The common theme is embryogenesis and subsequent organ formation rather than a single pathway, justifying a label focused on development and organogenesis.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060536","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0060806","count":2}]},{"hash":"64461904682549755","title":"Unknown","description":"The top GO terms are scattered across ubiquitin-dependent degradation, telomere maintenance, cell polarity, proteasome assembly, stress responses, and various signaling pathways, with no shared biological process or interactions linking the proteins. This lack of cohesive function and absence of edges suggest the cluster does not represent a single, interpretable module.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:1904357","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0070682","count":2},{"id":"GO:0009409","count":2}]},{"hash":"127302133718382761","title":"Folate and One-Carbon Metabolism","description":"The GO terms cluster around dihydrofolate/tetrahydrofolate biosynthesis, folate metabolism, one-carbon metabolism, glycine synthesis, dTMP biosynthesis, and methylation. These collectively define the folate/one-carbon metabolic pathway that provides methyl groups for nucleotide synthesis and methylation reactions. Some terms like axon regeneration and superoxide regulation may be ancillary or context-specific rather than core to this cluster. Overall, the dominant theme is folate-driven one-carbon metabolism and methylation.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046452","count":1},{"id":"GO:0046654","count":1},{"id":"GO:0006545","count":1},{"id":"GO:0046655","count":1},{"id":"GO:0006730","count":1}]},{"hash":"1362184167565592931","title":"Golgi/COPI vesicle trafficking","description":"Top GO terms cluster around vesicle formation and Golgi-associated transport (synaptic vesicle budding; COPI coating of Golgi vesicles; Golgi to transport vesicle movement), with small GTPase\u2013mediated signaling supporting trafficking. This combination suggests the proteins function in Golgi-based vesicle trafficking and membrane remodeling, rather than a single signaling or apoptotic pathway; secondary terms like polarity or apoptosis are less central to the core theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070142","count":2},{"id":"GO:1903527","count":2},{"id":"GO:0097284","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0007624","count":2}]},{"hash":"254126816094944673","title":"RNA processing and translation regulation","description":"This cluster\u2019s GO terms converge on RNA metabolism and control of protein synthesis (mRNA stability under stress, mRNA modification, splicing regulation, ncRNA-mediated silencing) and translation initiation, including viral translation reinitiation, indicating a cohesive theme of post-transcriptional regulation.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":4},{"id":"GO:0075525","count":3},{"id":"GO:1901407","count":3},{"id":"GO:0006378","count":3},{"id":"GO:1902625","count":3}]},{"hash":"2181446774882376331","title":"Unknown","description":"The top GO terms span telomere maintenance regulation, epithelial polarity, proteasome assembly, cold response, chemokine production, Wnt signaling, cardiac action potential regulation, foam cell differentiation, and NOD-like receptor signaling. They represent diverse, largely independent processes with no clear shared function across the four proteins, and there are no edges to suggest a cohesive interaction network. Therefore, there isn\u2019t a single representative function for this cluster.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904357","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0070682","count":2},{"id":"GO:0009409","count":2},{"id":"GO:0071651","count":2}]},{"hash":"1079269965399343907","title":"Muscle and Neural Cytoskeletal Dynamics","description":"This cluster\u2019s top GO terms cluster around cytoskeletal organization and cell adhesion (sarcomere organization, focal adhesion assembly, microspike assembly, substrate adhesion-dependent spreading, regulation of muscle contraction) along with neural development processes (lateral motor column neuron migration, spinal cord neuron differentiation, forebrain progenitor division). The recurring theme is cytoskeletal reorganization and adhesion-mediated processes that drive muscle structure and neural development, suggesting these proteins participate in cytoskeletal dynamics bridging muscle and neural contexts (with some shared adhesion biology also touching platelets). Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":2},{"id":"GO:0097477","count":2},{"id":"GO:0034446","count":2},{"id":"GO:0070527","count":2},{"id":"GO:0048041","count":1}]},{"hash":"1094676667814979225","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000380","count":1},{"id":"GO:0000395","count":1},{"id":"GO:0010448","count":1},{"id":"GO:0010449","count":1},{"id":"GO:0031497","count":1}]},{"hash":"1918479217436076228","title":"Mitochondrial outer membrane organization and apoptosis","description":"The terms cluster around mitochondrial outer membrane processes, including outer membrane organization, translocase complex assembly, and regulation of cytochrome c release, together with hydrogen peroxide\u2013mediated programmed cell death and protein insertion into the outer membrane. A few outliers (e.g., chitin-based cuticle development) seem unrelated to mitochondria, but the dominant theme is mitochondrial outer membrane dynamics linked to apoptosis.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007008","count":1},{"id":"GO:0070096","count":1},{"id":"GO:0006626","count":1},{"id":"GO:0008363","count":1},{"id":"GO:0090200","count":1}]},{"hash":"1717679244401915081","title":"Neuronal signaling and sensory processing","description":"The GO terms cluster around nervous system functions: GABA signaling, acetylcholine and histamine responses, innervation, sensory processing, and modulation of action potentials. This suggests the proteins participate in neurotransmission and sensory information handling, with additional context of neuromodulatory responses to xenobiotics (insecticides, cocaine). Overall, the cluster seems to reflect neuronal communication rather than metabolic processes.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0017085","count":2},{"id":"GO:0045759","count":2},{"id":"GO:0050893","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0071294","count":2}]},{"hash":"2169247563784357257","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016267","count":1},{"id":"GO:0060576","count":1},{"id":"GO:0000395","count":1},{"id":"GO:0010087","count":1},{"id":"GO:0000389","count":1}]},{"hash":"192580233660573204","title":"Oocyte polarization and pole plasm localization","description":"This cluster is dominated by GO terms related to oogenesis in Drosophila, especially pole plasm and oskar mRNA localization, pole plasm protein localization, and oocyte microtubule cytoskeleton polarization. Additional terms like megagametogenesis and polar nucleus fusion reinforce the reproductive development theme, with ribosome biogenesis and pre-replicative complex assembly likely reflecting concurrent cellular processes. Overall, the common thread is oocyte maturation with localized determinants and polarized cytoskeleton.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045451","count":2},{"id":"GO:0007318","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0000184","count":2},{"id":"GO:0008103","count":2}]},{"hash":"1107983437355193478","title":"Vertebrate Organogenesis and Morphogenesis","description":"The top GO terms cluster around organ development and tissue morphogenesis across multiple organs (eye, inner ear, pancreas, salivary gland, heart field, telencephalon) and differentiation processes (endoderm, adipocytes, collagen biosynthesis). Even without observed edges, the common theme is developmental regulation, so this label captures the probable function of the proteins as contributors to vertebrate organogenesis and tissue differentiation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050765","count":2},{"id":"GO:0048839","count":2},{"id":"GO:0035987","count":2},{"id":"GO:0045599","count":2},{"id":"GO:0003323","count":2}]},{"hash":"54189630359919412","title":"ER Targeting and Translocation","description":"The GO terms center on SRP-dependent cotranslational targeting to the ER membrane, post-translational ER targeting, Sec transport, and related ER-to-cytosol trafficking and quality-control processes, suggesting proteins in this cluster function together in directing and translocating nascent and post-translational cargo through the ER and associated pathways. The presence of SRP, Sec complex, and ERAD/retrograde transport terms supports a cohesive ER-targeting/translocation module, with a minor tRNA processing term that seems less central. ","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":2},{"id":"GO:0039019","count":1},{"id":"GO:0006620","count":1},{"id":"GO:0031204","count":1},{"id":"GO:0030433","count":1}]},{"hash":"1382600209970012898","title":"Cytoskeletal Remodeling and Epithelial Polarity","description":"The GO terms point to actin-based protrusions (podosome, microspike assembly) and processes establishing cell polarity, with supporting signaling and morphogenesis links (PDGF signaling, epithelial polarity). This suggests a cluster focused on cytoskeletal remodeling that underpins adhesion and polarity rather than a single enzymatic pathway. Therefore, the label captures the shared theme of cytoskeletal dynamics and epithelial organization.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060368","count":1},{"id":"GO:1902951","count":1},{"id":"GO:0032959","count":1},{"id":"GO:0071800","count":1},{"id":"GO:0009952","count":1}]},{"hash":"1320173208493095000","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071035","count":1},{"id":"GO:0034476","count":1},{"id":"GO:0000480","count":1},{"id":"GO:0000472","count":1},{"id":"GO:0071033","count":1}]},{"hash":"1119546448654030434","title":"Larval chitin-based cuticle development","description":"The top GO term is larval chitin-based cuticle development (GO:0008363) with four proteins, indicating a shared role in forming or remodeling the larval cuticle made of chitin. The cluster\u2019s small size and lack of other strong terms suggest a focused module involved in larval cuticle processes rather than broader pathways.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4}]},{"hash":"1862226684706618898","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000464","count":3},{"id":"GO:1904574","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0045003","count":3},{"id":"GO:1902775","count":3}]},{"hash":"1438687683529919816","title":"Skeletal muscle sarcomere organization and actin dynamics","description":"This label captures the cluster's strongest signals: skeletal muscle fiber adaptation, sarcomere organization, and actin filament polymerization/localization, suggesting a shared role in muscle cytoskeleton and contraction. Some terms (transcription by RNA polymerase II, ascospore wall assembly) are less related and may reflect broader cellular processes or annotation noise.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043503","count":2},{"id":"GO:0006366","count":2},{"id":"GO:0030476","count":1},{"id":"GO:0002121","count":1},{"id":"GO:0042766","count":1}]},{"hash":"2130561256062088750","title":"Insect Neuronal Signaling and Ion Transport","description":"The GO terms cluster around neural communication and ion handling in insects: GABA signaling, excitatory/inhibitory postsynaptic potentials, sensory processing, and sodium/more generally ion transport, plus responses to insecticides and other neuroactive compounds. A single term about larval cuticle development appears incidental to the main theme. This combination points to proteins involved in neuronal signaling and ion homeostasis rather than a non-neural process.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0008363","count":1},{"id":"GO:0017085","count":1},{"id":"GO:0045759","count":1}]},{"hash":"565696768285955576","title":"Unknown","description":"The top terms span intestinal lipid catabolic process, pancreatic juice secretion, mitochondrial inner membrane insertion, and insect cuticle development, with several entries marked obsolete and no unifying function across the proteins. With zero edges, no shared pathway or localization emerges, so a concise, representative label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044258","count":1},{"id":"GO:0018350","count":1},{"id":"GO:0030157","count":1},{"id":"GO:0072321","count":1},{"id":"GO:0045039","count":1}]},{"hash":"1651878274545425204","title":"Nuclear RNA Processing and Chromatin Regulation","description":"This cluster centers on nuclear RNA processing and chromatin dynamics, with GO terms for transcription termination by RNA Pol II, mRNA decay pathways (deadenylation-dependent decapping), spliceosome and P-body related RNA metabolism, and rRNA maturation plus histone mRNA metabolism. It also includes chromatin-associated processes such as pericentric heterochromatin formation and histone gene regulation, as well as nuclear import and cell-cycle transition regulation. Taken together, the proteins likely participate in coordinating RNA processing and chromatin state in the nucleus.","confidence":"High","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006369","count":3},{"id":"GO:1990141","count":2},{"id":"GO:0070317","count":2},{"id":"GO:0000290","count":2},{"id":"GO:0030490","count":2}]},{"hash":"239794509031536671","title":"RNA processing and splicing machinery","description":"The cluster is dominated by terms related to RNA maturation: RNA splicing, spliceosomal disassembly, mRNA capping and cap1 methylation, and helicase activity linked to RNA processing, suggesting a core theme around RNA processing and spliceosome function with some auxiliary protein interaction signals (e.g., homooligomerization). ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0007175","count":1},{"id":"GO:0006370","count":1},{"id":"GO:0097309","count":1},{"id":"GO:1904751","count":1}]},{"hash":"1078582822343759713","title":"Chromatin organization and histone modification","description":"This cluster centers on chromatin regulation: histone modification (including H3-K27 methylation), heterochromatin formation, nucleosome mobilization/condensation, and localization of proteins to chromatin. The common theme is chromatin organization and its control over transcription and development, which aligns with the included developmental GO terms as well.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061086","count":3},{"id":"GO:0000183","count":3},{"id":"GO:0071674","count":3},{"id":"GO:0042766","count":3},{"id":"GO:0001649","count":3}]},{"hash":"963821455557406026","title":"RNA maturation and transcription regulation","description":"The GO terms cluster around RNA modification and processing, notably tRNA N1-guanine methylation, wybutosine biosynthesis, 7-methylguanosine RNA capping, and rRNA processing, with additional links to transcription (DNA-templated transcription and negative regulation of transcription by RNA Pol II). This suggests a cohesive theme of RNA maturation coupled with transcription control, though a few terms (e.g., cobalamin biosynthesis) may reflect broader metabolic annotations or noise. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009236","count":2},{"id":"GO:0019919","count":2},{"id":"GO:0006351","count":1},{"id":"GO:0006364","count":1},{"id":"GO:0090398","count":1}]},{"hash":"1583929330425351809","title":"Ubiquitin/Neddylation in Innate Immune Signaling","description":"This cluster is centered on post-translational modifications\u2014K11-linked ubiquitination and neddylation\u2014and their roles in regulating innate immune signaling pathways (TRIF-dependent TLR and CLEC receptor signaling). While some terms relate to chromatin modification and DNA repair, the strongest, most represented themes are ubiquitin/neddylation-based regulation of immune signaling, suggesting a cohesive function in PTM-controlled innate responses.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0070979","count":4},{"id":"GO:0035666","count":4},{"id":"GO:0051026","count":4},{"id":"GO:0002223","count":4},{"id":"GO:0031058","count":4}]},{"hash":"241907237135283215","title":"Actin cytoskeleton remodeling and sarcomere organization","description":"The cluster is enriched for terms related to actin dynamics and muscle structure: actin cortical patch localization, actin filament polymerization, postsynaptic actin cytoskeleton organization, and sarcomere organization (with supporting terms like skeletal muscle fiber adaptation). Some terms appear obsolete or incidental (ascospore wall assembly, inter-male aggressive behavior, etc.), but the core theme across the proteins points to actin cytoskeleton remodeling and muscle architecture.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030476","count":4},{"id":"GO:0002121","count":4},{"id":"GO:0042766","count":4},{"id":"GO:0032508","count":4},{"id":"GO:0045214","count":4}]},{"hash":"1722978923511683041","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0007250","count":2},{"id":"GO:0050909","count":1},{"id":"GO:0000480","count":1},{"id":"GO:0070979","count":1}]},{"hash":"1341182321563215590","title":"Apoptosis and innate immune signaling","description":"The top GO terms cluster around apoptosis (including pyroptosis) and innate immune response, with ubiquitination as a regulatory mechanism, suggesting a functional theme of programmed cell death intertwined with immune signaling. Additional terms like mitotic spindle assembly and RISC complex assembly hint broader regulatory roles, but the core connection appears to be cell death and immune regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990001","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0070269","count":3},{"id":"GO:0006915","count":3}]},{"hash":"1549048113776315629","title":"Chromatin modification and RNA-mediated regulation in plants","description":"The terms cluster around chromatin regulation (histone acetylation), RNA-based control (miRNA processing, RNA silencing, ncRNA-driven heterochromatin) and plant development (shoot apical meristem maintenance, megasporocyte differentiation), suggesting a shared epigenetic/post-transcriptional mechanism in plant development.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000617","count":1},{"id":"GO:0010501","count":1},{"id":"GO:1904159","count":1},{"id":"GO:2000636","count":1},{"id":"GO:0060903","count":1}]},{"hash":"2097868308580281600","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060441","count":3},{"id":"GO:0043010","count":3},{"id":"GO:0006366","count":3},{"id":"GO:0048048","count":3},{"id":"GO:0019101","count":2}]},{"hash":"943174489215265700","title":"Transmembrane Transport of Small Molecules","description":"The cluster\u2019s top GO terms cluster around transmembrane transport of xenobiotics, vitamins, sugars, phosphate, and related substrates, suggesting a group of membrane transport proteins with diverse small-molecule substrates. The presence of an osmotic-stress response term may reflect regulatory or stress-related modulation of transport activity rather than a separate substrate class.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042908","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0006855","count":4},{"id":"GO:0035461","count":4},{"id":"GO:1900754","count":3}]},{"hash":"1963785177963464480","title":"Plant secondary metabolism and xenobiotic detoxification","description":"The top GO terms point to biosynthesis of plant-derived compounds (flavonoids like quercetin glucosides, lignin) and xenobiotic processing (glucuronidation), with a few broader metabolic and phytohormone-related terms. This pattern suggests a cluster focused on metabolism of plant secondary metabolites and detoxification rather than a single uniform pathway. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":3},{"id":"GO:0033303","count":2},{"id":"GO:0002175","count":2},{"id":"GO:0030259","count":2},{"id":"GO:0052697","count":2}]},{"hash":"463242001956815411","title":"Adaptive immune response and coagulation","description":"This cluster shows GO terms centered on adaptive immune response (GO:0002250), blood coagulation (GO:0007596), and regulation of interleukin-1 production (GO:0032652), with additional signals related to neutrophil apoptosis, vesicle fusion, and extracellular matrix organization. Together these terms point to immune activation accompanied by inflammatory signaling and vascular/ECM remodeling, suggesting a coherent theme around immune response and coagulation rather than a non-specific set of processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0052405","count":1},{"id":"GO:0033031","count":1},{"id":"GO:0031340","count":1},{"id":"GO:0007596","count":1},{"id":"GO:0032652","count":1}]},{"hash":"2066520642539507270","title":"Metabolic and Redox Stress Response","description":"The cluster\u2019s top GO terms point to metabolic adjustments (malate, glucose, lactate production, NADH) intersecting with redox and stress signaling (response to xenobiotic stimulus, hydrogen peroxide) and broader cellular signaling (estrogen, cAMP) plus apoptosis regulation, suggesting a group coordinating metabolic state with stress responses rather than a single pathway.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0019244","count":2},{"id":"GO:0043627","count":2},{"id":"GO:0006108","count":2}]},{"hash":"1306748484128261887","title":"RNA Pol II Transcription Regulation","description":"GO terms point to transcriptional regulation by RNA polymerase II, including DNA-templated transcription and RNA Pol II preinitiation complex assembly, which ties the proteins to transcription initiation/regulation. The single term on neuroblast proliferation suggests a potential link to neurodevelopmental regulation but does not redefine the primary theme.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006357","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0051123","count":1},{"id":"GO:0007406","count":1}]},{"hash":"1050259941175865001","title":"ER-Golgi trafficking and Wnt secretion","description":"This cluster centers on COPI-coated vesicles and ER-to-Golgi transport, including Golgi ribbon formation and regulation of protein exit from the ER, which together point to vesicle trafficking and protein secretion. GO terms for COPI vesicle budding/coating and Wnt secretion reinforce a theme of secretory pathway function, with developmental signals like somite axis specification and amyloid-beta regulation as broader associations. Overall, the dominant signal is vesicle transport between the ER and Golgi and related secretion processes.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048042","count":1},{"id":"GO:0002121","count":1},{"id":"GO:0035964","count":1},{"id":"GO:0070863","count":1},{"id":"GO:1902003","count":1}]},{"hash":"1270347579235466127","title":"Ribosome biogenesis and RNA modification","description":"These proteins are linked to RNA biology, especially assembly of the ribosomal small subunit and various RNA modifications. The dominant GO terms include ribosomal small subunit biogenesis, rRNA methylation and acetylation, and tRNA wobble cytosine modification, pointing to roles in RNA processing and ribosome maturation. Additional terms reference transcription regulation and telomere maintenance, which may reflect broader genome stability and cell cycle connections, but the strongest signal is RNA processing and ribosome assembly.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070317","count":1},{"id":"GO:0042274","count":1},{"id":"GO:0002101","count":1},{"id":"GO:0051391","count":1},{"id":"GO:1904812","count":1}]},{"hash":"1620270300226503801","title":"Embryonic neural and organ morphogenesis","description":"The top GO terms point to development and morphogenesis across multiple tissues: neural structures (hindbrain morphogenesis, floor plate development, oculomotor nerve development, neuron development) and organ/tissue morphogenesis (sinus venosus morphogenesis, mesenchyme development, stomatal complex development). This suggests a shared theme of embryonic tissue patterning and morphogenesis, despite some terms being plant-specific or obsolete. Confidence: Medium","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010374","count":4},{"id":"GO:0035481","count":4},{"id":"GO:0042981","count":4},{"id":"GO:0033504","count":4},{"id":"GO:0003236","count":4}]},{"hash":"375343944638330172","title":"ECM and Neuronal Junction Organization","description":"This cluster is dominated by extracellular matrix and cell-adhesion processes (collagen fibril organization, hemidesmosome assembly) and includes terms related to neuronal junctions and axon organization (paranode region localization, synapse organization). Despite a couple of unrelated signaling terms, the prevailing pattern points to ECM remodeling coupled with the establishment/maintenance of neural connections.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:2001108","count":3},{"id":"GO:1902771","count":3},{"id":"GO:0060116","count":3},{"id":"GO:0002175","count":3}]},{"hash":"226246336748155902","title":"Actin dynamics and vesicle trafficking","description":"The cluster is dominated by GO terms related to actin cytoskeleton regulation (barbed-end capping, actin filament severing, microvillus length regulation) and vesicle-mediated transport between ER and Golgi, suggesting a core theme of actin-driven remodeling coupled with secretory trafficking, with additional morphogenesis-related terms that fit downstream effects of these processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051016","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0043547","count":2},{"id":"GO:1903689","count":1}]},{"hash":"741544626023812925","title":"Developmental differentiation and MAPK signaling","description":"The cluster centers on transcriptional control and signaling that drive cell fate and differentiation across tissues, with GO terms including DNA-templated transcription, p38MAPK cascade, and multiple differentiation processes (neural, myoblast, mammary gland, pneumocyte), suggesting a broad developmental signaling theme rather than a single specific pathway.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0060748","count":1},{"id":"GO:0021872","count":1},{"id":"GO:2000288","count":1},{"id":"GO:0038066","count":1}]},{"hash":"1414504014573834390","title":"Macromolecular Complex Assembly","description":"Dominant GO terms describe assembly of RNA polymerase I/II/III complexes and the tubulin complex, suggesting a shared theme of macromolecular complex assembly; other, less related terms appear ancillary.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1990115","count":1},{"id":"GO:0032968","count":1},{"id":"GO:1990114","count":1},{"id":"GO:1990113","count":1},{"id":"GO:0007021","count":1}]},{"hash":"2218142548062159502","title":"Acetylation and acetyl-CoA metabolism","description":"Most of the GO terms point to acetylation reactions: spermidine acetylation, peptidyl-lysine N6-acetylation, and acetylation of histone H4, as well as other acetylation-related processes. The remaining terms (N-acetylglucosamine/N-acetylglucosamine metabolic, mycothiol biosynthesis, acetoin catabolic process) are connected to acetyl group transfer or acetyl-CoA\u2013dependent steps, suggesting the enzymes in this cluster participate in acetylation chemistry or acetyl-CoA\u2013driven metabolism. Although there is a stray term related to chromatid cohesion, the dominant signal is acetylation. Therefore label as Acetylation and acetyl-CoA metabolism.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032918","count":3},{"id":"GO:0046208","count":3},{"id":"GO:0010125","count":3},{"id":"GO:0018003","count":3},{"id":"GO:0043967","count":3}]},{"hash":"679638086102375535","title":"Unknown","description":"The GO terms are highly diverse, spanning cellular heat response, riboflavin transport, sensory perception, multiple post-translational modifications, and broad signaling pathways across different organismal systems. There is no clear, shared function tying these four proteins together, so a specific, representative name cannot be confidently assigned. ","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034605","count":1},{"id":"GO:0032218","count":1},{"id":"GO:0007605","count":1},{"id":"GO:0006478","count":1},{"id":"GO:2000324","count":1}]},{"hash":"1698906200849528706","title":"Carotenoid-derived metabolism and signaling in plants","description":"The proteins cluster around carotenoid-derived pathways: strigolactone biosynthesis, xanthophyll catabolism, and retinal/vitamin A\u2013related metabolism, which ties to carbon-derivative signaling affecting growth and shoot development (secondary shoot formation, regulation of cell growth). Some terms related to photoreception/light sensing (phototransduction, visual perception, retina homeostasis) may reflect broad light-response roles of carotenoid metabolites. Overall, the theme is carotenoid-derived metabolite biosynthesis and signaling in plant growth and light responses.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001558","count":2},{"id":"GO:0051497","count":2},{"id":"GO:1901601","count":1},{"id":"GO:0035238","count":1},{"id":"GO:0016124","count":1}]},{"hash":"1567710389629713190","title":"mRNA processing and translation regulation","description":"This cluster is best described by post-transcriptional gene expression control, centering on mRNA polyadenylation and deadenylation-dependent decay alongside cytoplasmic translation and translational elongation. While a few terms reference broader signaling or differentiation processes, the dominant pattern points to RNA metabolism and regulation of protein synthesis.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0098789","count":1},{"id":"GO:0046782","count":1},{"id":"GO:0045657","count":1},{"id":"GO:0038066","count":1},{"id":"GO:0097403","count":1}]},{"hash":"1738339479547888833","title":"Unknown","description":"The top GO terms show a mix of stimuli responses (estradiol, UV-A, gamma radiation, heat), transport regulation, lens morphogenesis, and muscle activity, with no dominant shared function. This scattered set makes it inappropriate to assign a cohesive label beyond Unknown.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032355","count":1},{"id":"GO:0099641","count":1},{"id":"GO:0032387","count":1},{"id":"GO:0070141","count":1},{"id":"GO:0007568","count":1}]},{"hash":"1994772397259824304","title":"Unknown","description":"No GO terms are provided for this cluster (Top Terms is empty). The cluster shows only one edge, max degree 1, and a sizable set of proteins re-added by ReCIPE, but there is no evident shared function or process to define a cohesive theme. Therefore a specific label cannot be assigned.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[]},{"hash":"326272104927643146","title":"Unknown","description":"These terms span organ morphogenesis (metanephric kidney structures, lymph vessel morphogenesis, cartilage condensation) and several immune signaling pathways (complement lectin pathway, Fc-gamma receptor, C-type lectin receptor) plus NK cell chemotaxis regulation. Because there isn't a single, coherent biological process tying all terms together, a precise, unified label is not justifiable.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":2},{"id":"GO:0051873","count":2},{"id":"GO:0036303","count":2},{"id":"GO:0002223","count":2},{"id":"GO:0090403","count":2}]},{"hash":"2144561346273547993","title":"Lectin receptor\u2013mediated innate immunity","description":"The proteins in this cluster show enrichment for innate immune recognition and signaling terms, including phagocytosis recognition, C-type lectin receptor signaling, complement activation via the lectin pathway, Fc-gamma receptor signaling, and NK cell chemotaxis regulation. Some unrelated developmental terms may reflect annotation noise, but the dominant theme is lectin- and receptor-mediated immune sensing and response.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006910","count":2},{"id":"GO:0072218","count":1},{"id":"GO:0051873","count":1},{"id":"GO:0036303","count":1},{"id":"GO:0002223","count":1}]},{"hash":"858870801185295022","title":"Neurodevelopment and GABA Metabolism","description":"The cluster shows strong representation of nervous system development terms (forebrain, olfactory pit, nose, pituitary; anterior/posterior pattern specification) along with GABA metabolic terms (GABA shunt, GABA catabolic process). This pattern suggests the proteins function together in brain development and GABA neurotransmission. Some terms are more peripheral (embryonic digestive tract development, obsolete catabolic processes), but the dominant theme is neurodevelopment with GABA pathways.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":3},{"id":"GO:0006540","count":3},{"id":"GO:0043584","count":3},{"id":"GO:0019544","count":3},{"id":"GO:0010133","count":3}]},{"hash":"487902667855711355","title":"Unknown","description":"The GO terms span development and morphogenesis (body, stomatal, cuticle), metabolism-related processes (ERAD-related glycoprotein trimming, protein catabolic process in the vacuole), immune-related activity (isotype switching), and iron metabolism (iron transport and homeostasis). The lack of a unifying function and the absence of edges among the proteins suggest this cluster does not map to a single coherent biological theme, so a precise, representative label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010171","count":1},{"id":"GO:0040003","count":1},{"id":"GO:0042135","count":1},{"id":"GO:1904382","count":1},{"id":"GO:0045830","count":1}]},{"hash":"1621879133364025572","title":"Neuronal synaptic plasticity and transmission","description":"Dominant GO terms include regulation of long-term neuronal synaptic plasticity, sensory perception of touch, and excitatory postsynaptic potential, which together suggest proteins involved in synaptic signaling and plasticity in neurons. Other terms appear incidental.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048169","count":2},{"id":"GO:0050975","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0001998","count":1},{"id":"GO:0071806","count":1}]},{"hash":"137342835056128143","title":"Unknown","description":"The GO terms span very disparate contexts\u2014from cellular signaling (cAMP), cold and chemical responses (carbon monoxide) to immune cytokine regulation, tactile sensory detection, brain development, and cardiac stress responses\u2014with no clear, cohesive function tying the proteins together. The lack of shared edges also suggests there is no single predominant function. Hence, there isn\u2019t a reliable, representative label beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071320","count":1},{"id":"GO:0009409","count":1},{"id":"GO:0002724","count":1},{"id":"GO:0050976","count":1},{"id":"GO:0034465","count":1}]},{"hash":"958797274567653775","title":"Chloroplast Carbohydrate Metabolism","description":"The cluster shows multiple GO terms tied to central carbon metabolism (glycolysis, gluconeogenesis, pentose phosphate pathway) and plastid-related function (chloroplast organization), suggesting a plastid-associated carbohydrate metabolism theme. Developmental terms like root development and multicellular reproduction appear less central to these proteins and may reflect broader annotations. ","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0080022","count":1},{"id":"GO:0061621","count":1},{"id":"GO:0032504","count":1},{"id":"GO:0046166","count":1},{"id":"GO:0006094","count":1}]},{"hash":"2043873575608115400","title":"Transmembrane Transporters","description":"The top GO terms are all about transporting various substrates across membranes (sugars, nitrite, vitamins, xenobiotics, phosphate, etc.), indicating a cohesive function group of membrane transport proteins handling diverse compounds.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900754","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0015739","count":2},{"id":"GO:0006004","count":2}]},{"hash":"1954963554422740809","title":"DNA Transposons","description":"The top GO terms are DNA integration and DNA transposition, both describing movement of DNA within the genome, which is characteristic of transposable elements. The presence of these terms in this small cluster suggests the proteins function in transposition-related processes.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":1},{"id":"GO:0006313","count":1}]},{"hash":"1373572920463687150","title":"Ubiquitin-Dependent Regulation of Apoptosis and Immunity","description":"The terms emphasize ubiquitin-mediated protein degradation (ubiquitin-dependent proteolysis, protein ubiquitination) together with apoptosis regulation (positive/negative regulation) and adaptive immune response, suggesting a core theme of ubiquitin-driven control of cell death and immune signaling; additional terms hint at broader regulation via transcription and receptor turnover.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0042981","count":2},{"id":"GO:0038018","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0002250","count":2}]},{"hash":"470042531481357364","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050909","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0001403","count":2},{"id":"GO:2001235","count":2},{"id":"GO:0010659","count":2}]},{"hash":"2175812461320094314","title":"RNA processing and chromatin regulation","description":"The cluster combines RNA metabolism activities (deadenylation-dependent mRNA decapping, spliceosomal assembly, SSU-rRNA maturation, transcription termination, histone mRNA metabolism, P-body assembly) with chromatin-related processes (pericentric heterochromatin formation, histone mRNA metabolism) and nuclear import, suggesting a core theme of nuclear RNA processing closely tied to chromatin state.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1990141","count":2},{"id":"GO:0070317","count":2},{"id":"GO:0000290","count":2},{"id":"GO:0030490","count":2},{"id":"GO:0006369","count":2}]},{"hash":"2184180264497653711","title":"Unknown","description":"The top terms show vascular development (inhibition of endothelial proliferation and angiogenesis) but also neuronal signaling ideas (K+ channel clustering, presynaptic Ca2+ regulation, synaptic potentiation). With only three proteins and no single cohesive function linking these terms, there isn\u2019t a clear shared theme to assign a specific label.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001937","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0045163","count":1},{"id":"GO:0008360","count":1},{"id":"GO:0099509","count":1}]},{"hash":"1602234888282665549","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0050909","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0001403","count":3},{"id":"GO:2001235","count":3},{"id":"GO:0010659","count":3}]},{"hash":"968770279982089844","title":"Calcium signaling in neural and cardiac development","description":"The top GO terms emphasize calcium-dependent signaling pathways (calcineurin-NFAT) linked to neural differentiation, morphine response, and developmental contexts like lung and cardiac muscle remodeling, suggesting a shared role for calcium signaling in neural and cardiac development and neural-related responses. Some terms (cell cycle, metabolism) are peripheral, but the central theme remains calcium-mediated signaling in development and neural function.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030182","count":3},{"id":"GO:0005979","count":3},{"id":"GO:0000082","count":3},{"id":"GO:0032516","count":3},{"id":"GO:0031573","count":3}]},{"hash":"1464332167617227516","title":"Meiotic Recombination and DNA Repair","description":"GO terms strongly point to recombination and meiosis, including DNA recombination, meiotic joint molecule formation, SD\u2011SA repair, and mating-type switching, plus t-circle formation suggesting telomere recombination. Some metabolic terms appear but do not define the core function. ","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0009052","count":1},{"id":"GO:0019323","count":1},{"id":"GO:0044262","count":1}]},{"hash":"1743850222880661663","title":"Nucleotide Metabolism and Salvage","description":"Most of the terms describe nucleotide metabolism: AMP salvage, ADP/GTP metabolic processes, CDP biosynthesis, nucleoside monophosphate phosphorylation, and purine ribonucleotide interconversion, suggesting a shared role in maintaining and interconverting nucleotide pools. The brain and liver development terms seem incidental or reflect broader expression rather than core function. Thus, the cluster is best labeled by its primary biochemical theme: nucleotide metabolism.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0044209","count":3},{"id":"GO:0046705","count":3},{"id":"GO:0046939","count":3},{"id":"GO:0046041","count":3},{"id":"GO:0046940","count":3}]},{"hash":"60001772776306803","title":"Folate-dependent one-carbon metabolism proteins","description":"The top GO terms cluster around L-serine biosynthesis and catabolism, tetrahydrofolate interconversion, and dTMP biosynthesis, all central to folate-dependent one-carbon metabolism and nucleotide biosynthesis. Additional terms like methylation and translation regulation may reflect broader cellular regulation, but the core theme is one-carbon metabolism facilitated by folate cycling.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034340","count":1},{"id":"GO:0006564","count":1},{"id":"GO:0046655","count":1},{"id":"GO:0006565","count":1},{"id":"GO:0006231","count":1}]},{"hash":"143484640694321979","title":"Ribosome biogenesis and RNA processing","description":"The GO terms strongly point to RNA metabolism and ribosome assembly, notably endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA (a key step in rRNA processing) and mitochondrial large ribosomal subunit assembly. Other terms relate to RNA stability and decay, supporting a theme around RNA maturation and quality control. A number of terms are obsolete, but the core signal remains RNA processing/ribosome biogenesis rather than a single signaling or repair pathway, justifying a concise, specific label.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000464","count":3},{"id":"GO:1904574","count":3},{"id":"GO:0045003","count":3},{"id":"GO:1902775","count":3},{"id":"GO:0060303","count":3}]},{"hash":"391253174821918288","title":"Chromatin Remodeling and Heterochromatin Assembly","description":"The cluster is dominated by GO terms related to chromatin organization and remodeling (rDNA heterochromatin formation, transcription initiation-coupled chromatin remodeling, DNA replication-dependent chromatin assembly, establishment of protein localization to chromatin, and histone methylation regulation), suggesting a cohesive theme of chromatin dynamics. A couple terms about cell migration and osteoblast differentiation are present but appear less central to the core function of chromatin regulation.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000183","count":3},{"id":"GO:0051290","count":3},{"id":"GO:0045815","count":3},{"id":"GO:0006335","count":3},{"id":"GO:0061086","count":2}]},{"hash":"637309959674859277","title":"Cell Division and DNA Partitioning","description":"The GO terms strongly point to cell cycle, chromosome segregation, and plasmid partitioning, indicating a cluster of proteins involved in cell division and DNA partitioning. Auxiliary terms like iron-sulfur cluster assembly and tRNA wobble modification may reflect broader cellular functions, but the core signal is division-related DNA handling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016226","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0045226","count":1},{"id":"GO:0018108","count":1},{"id":"GO:0030541","count":1}]},{"hash":"203771741867658294","title":"Antiviral NF-\u03baB\u2013driven immune signaling","description":"The top GO terms cluster around antiviral immune responses and NF-\u03baB signaling, including non-canonical NF-\u03baB pathway activity, leukocyte migration, and chemokine production, suggesting roles in immune activation and cell trafficking during viral infection. While some terms reference viral life-cycle steps (uncoating, proviral latency), the recurring emphasis on NF-\u03baB regulation and leukocyte movement supports a cohesive theme of antiviral immune signaling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0019061","count":2},{"id":"GO:0050900","count":2},{"id":"GO:0075713","count":2},{"id":"GO:1901224","count":2}]},{"hash":"555867662618846950","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042619","count":1},{"id":"GO:0006704","count":1},{"id":"GO:0008207","count":1},{"id":"GO:0030148","count":1},{"id":"GO:0042351","count":1}]},{"hash":"2214910720674078972","title":"Unknown","description":"This cluster's top GO terms cover a wide range of unrelated processes (circadian regulation of gene expression, brown fat differentiation, inter-male aggression, embryonic epithelium morphogenesis, regulation of cell adhesion, endoderm differentiation, T cell antigen processing, notochord development, neuromuscular junction synaptic regulation, and mammary gland branching). Because there is no clear cohesive function linking these terms, a single interpretable label is not supported.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032922","count":2},{"id":"GO:0050873","count":1},{"id":"GO:0002121","count":1},{"id":"GO:0016331","count":1},{"id":"GO:0030155","count":1}]},{"hash":"1787348986414685309","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0050909","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0001403","count":2},{"id":"GO:2001235","count":2}]},{"hash":"1451252769868104176","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007014","count":1},{"id":"GO:0072089","count":1},{"id":"GO:0010586","count":1},{"id":"GO:2000637","count":1},{"id":"GO:1903886","count":1}]},{"hash":"498348834463599773","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":2},{"id":"GO:0010606","count":1},{"id":"GO:0006261","count":1},{"id":"GO:0000738","count":1},{"id":"GO:0034415","count":1}]},{"hash":"2082376350068329143","title":"Neural development and synaptic signaling","description":"Reasoning: The top GO terms cluster around neuronal development and synaptic regulation\u2014regulation of neuronal synaptic plasticity, kainate receptor activity regulation, axon guidance/nerve development, neural crest and sympathetic ganglion development, and PKC signaling. Some terms are broader morphogenesis concepts, but the strongest signal points to neural development and synaptic signaling. Confidence: Medium","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000312","count":2},{"id":"GO:0048168","count":2},{"id":"GO:0060672","count":2},{"id":"GO:0043050","count":1},{"id":"GO:1901166","count":1}]},{"hash":"1046204664243721904","title":"Unknown","description":"The GO terms span diverse developmental contexts (mammary gland morphogenesis, forebrain neuron generation, myoblast proliferation, type I pneumocyte differentiation, and male gonad development) along with a signaling pathway (p38MAPK cascade) and metabolic regulation, with no single cohesive function tying the proteins together, so a specific, representative label cannot be confidently assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060748","count":3},{"id":"GO:0021872","count":3},{"id":"GO:2000288","count":3},{"id":"GO:0038066","count":3},{"id":"GO:1905695","count":3}]},{"hash":"137112722942842651","title":"Neural development and brain regionalization","description":"The cluster\u2019s top GO terms are dominated by neural development and brain patterning processes, including telencephalon regionalization, hypothalamus differentiation, motor neuron axon guidance, neuron migration, and anterior/posterior pattern specification. Although a few terms pertain to other organs, the predominant signal points to neural tissue formation and brain region specification, justifying this label as representative of the cluster\u2019s function. ","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":2},{"id":"GO:0021527","count":1},{"id":"GO:0030878","count":1},{"id":"GO:0021978","count":1},{"id":"GO:0009952","count":1}]},{"hash":"325780014385179998","title":"Neural development and morphogenesis","description":"This cluster is driven by embryonic and neural-focused processes: notochord and embryonic body morphogenesis, vestibular receptor morphogenesis, and transmission of nerve impulse, plus voltage-gated potassium channel clustering consistent with neuronal signaling and associated tissue morphogenesis (collagen fibril organization, etc.). These terms collectively point to neural development and related morphogenetic processes rather than unrelated functions.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045163","count":3},{"id":"GO:0043277","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0060035","count":3},{"id":"GO:0010172","count":3}]},{"hash":"2100036786629865049","title":"Ribosome Biogenesis and Translation","description":"The top GO terms are centered on ribosome assembly and translation-related activities: ribosomal small subunit biogenesis, ribosome biogenesis, threonyl-tRNA aminoacylation, and tRNA modification. While there are also terms related to cell division (septum assembly, cell cycle), the strongest and most coherent signal is ribosome biogenesis and translation, making this the most representative label.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090529","count":1},{"id":"GO:0000747","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0042274","count":1},{"id":"GO:0042254","count":1}]},{"hash":"461427211771281058","title":"Amino acid biosynthesis and catabolism","description":"GO terms indicate multiple amino acid metabolic pathways (ornithine, proline, lysine, GABA, beta-alanine, putrescine) and related biosynthetic processes (biotin, protoporphyrinogen IX). This suggests a metabolic cluster focused on amino acid metabolism and crosstalk with broader biosynthesis, with the cocaine behavioral term likely an outlier.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048148","count":1},{"id":"GO:0019483","count":1},{"id":"GO:0006593","count":1},{"id":"GO:0009089","count":1},{"id":"GO:0009102","count":1}]},{"hash":"2282290275282541274","title":"Neural development and ECM remodeling","description":"This cluster centers on neural and sensory development (nerve impulse transmission; notochord and vestibular receptor morphogenesis) plus embryonic morphogenesis and extracellular matrix remodeling (collagen fibril organization) and ion-channel organization, suggesting a coordinated neural development program with ECM and tissue morphogenesis.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045163","count":3},{"id":"GO:0043277","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0060035","count":3},{"id":"GO:0010172","count":3}]},{"hash":"1593986065921082765","title":"Neural and Developmental Gene Expression","description":"The cluster shows strong representation of developmental processes (multicellular development, neural tube and forebrain development, skeletal system development) and transcription-related terms (DNA-templated transcription), suggesting a cohesive theme of developmental gene expression guiding growth and tissue formation. Some terms related to cell cycle and imprinting support broader regulation in development, while immune/ER stress terms appear less central.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0006349","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0006351","count":3}]},{"hash":"1335149641661896825","title":"Unknown","description":"No GO terms are provided for this cluster, so there is no clear shared function to base a label on; with only two edges and three proteins, a reliable functional name cannot be determined.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"210991813944670769","title":"Apoptosis and Innate Immunity","description":"The cluster\u2019s prominent GO terms point to programmed cell death and inflammatory signaling (apoptotic process, pyroptotic inflammatory response, innate immune response) with ubiquitin-mediated regulation, suggesting proteins involved in apoptosis and immune/inflammatory pathways. Some terms about sarcomere organization and angiogenesis appear, but the strongest shared theme is cell death and innate immunity.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990001","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0070269","count":2},{"id":"GO:0006915","count":2}]},{"hash":"1360095531545011691","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042953","count":1},{"id":"GO:0007601","count":1},{"id":"GO:0034260","count":1},{"id":"GO:1900186","count":1},{"id":"GO:0070121","count":1}]},{"hash":"821742351799689586","title":"Membrane Signaling and Epithelial Polarity","description":"The top GO terms point to membrane-associated signaling and transport (protein transmembrane transport; ephrin receptor signaling; angiotensin-mediated vasoconstriction) and to cellular organization in epithelial contexts (apical/basal polarity). Additional terms about GTPase regulation and ER stress response suggest the cluster centers on signaling pathways that govern cell architecture and secretory tissue development (e.g., salivary gland formation). While the terms span several related processes, the common thread appears to be membrane-initiated signaling linked to epithelial polarity and tissue development.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001998","count":2},{"id":"GO:0071806","count":2},{"id":"GO:0048013","count":2},{"id":"GO:0034260","count":2},{"id":"GO:0043497","count":2}]},{"hash":"1495103703617740370","title":"Tubulin assembly and microtubule organization","description":"This cluster is dominated by terms for tubulin complex assembly and cortical microtubule organization, plus chaperone-mediated protein folding and ubiquitin-proteasome\u2013dependent quality control, suggesting a role in chaperone-assisted tubulin maturation and cytosolic proteostasis; one term about transcription elongation may be incidental.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032968","count":1},{"id":"GO:0071629","count":1},{"id":"GO:0007021","count":1},{"id":"GO:0051131","count":1},{"id":"GO:0043622","count":1}]},{"hash":"701927774920217700","title":"Actin-Mediated Mitochondrial Inheritance","description":"This cluster's top terms center on actin cytoskeleton assembly (cortical patches and Arp2/3-mediated nucleation) and mitochondrial inheritance, indicating a cohesive theme around actin-driven mitochondrial distribution. The association suggests these proteins participate in actin dynamics that facilitate mitochondrion inheritance during cell division.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000147","count":1},{"id":"GO:0000001","count":1},{"id":"GO:0034314","count":1}]},{"hash":"1384519002885128157","title":"Embryonic development and organ morphogenesis","description":"The proteins are annotated with diverse developmental and morphogenesis terms across skeletal, vascular, respiratory, and neural tissues, pointing to a broad theme of embryonic organogenesis rather than a single pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001649","count":1},{"id":"GO:0060670","count":1},{"id":"GO:0033337","count":1},{"id":"GO:1990874","count":1},{"id":"GO:0060535","count":1}]}]