{"hash":"1795986221203118121","title":"Post-translational modification and membrane trafficking regulators","description":"The top GO terms emphasize protein deubiquitination and sumoylation (PTMs) alongside membrane trafficking processes (tail-anchored ER insertion, GPCR internalization) and signaling-related dynamics (mitochondrial fusion, calcium channels). This pattern suggests a cluster of proteins that regulate cellular signaling and protein localization through PTMs and trafficking mechanisms.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"members":[{"accession":"XP_026689474.2","go_terms":["GO:1903061","GO:0061321","GO:0090083","GO:0032435","GO:0090367","GO:0071260","GO:0097192","GO:0010664","GO:0097201","GO:0008625","GO:0051496","GO:0010763","GO:1902176","GO:0031397","GO:2001145","GO:0010228","GO:0042993","GO:0071364","GO:0097178","GO:0046827","GO:0061084","GO:1903215","GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412"]},{"accession":"XP_026689629.2","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_078490067.1","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]},{"accession":"XP_078494930.1","go_terms":["GO:1990592","GO:0033146"]},{"accession":"XP_002124862.2","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]},{"accession":"XP_002129578.1","go_terms":["GO:0034727","GO:0000422","GO:0061723","GO:0006501","GO:0035096","GO:0044805","GO:0032258","GO:0000045","GO:0000226","GO:0034198","GO:0010940","GO:0010040","GO:0034629","GO:0040024","GO:0008625","GO:0006888","GO:0097352","GO:0071211","GO:0070301","GO:0010288","GO:0061709","GO:0006915","GO:0043278","GO:0071280","GO:0070257"]},{"accession":"XP_002129622.1","go_terms":["GO:0034727","GO:0000422","GO:0061723","GO:0006501","GO:0035096","GO:0044805","GO:0032258","GO:0000045","GO:0000226","GO:0034198","GO:0010940","GO:0010040","GO:0034629","GO:0040024","GO:0008625","GO:0006888","GO:0097352","GO:0071211","GO:0070301","GO:0010288","GO:0061709","GO:0006915","GO:0043278","GO:0071280","GO:0070257"]},{"accession":"XP_009859868.2","go_terms":["GO:0032436","GO:0070911","GO:0034126","GO:0090204","GO:0010286","GO:1901896","GO:0071276","GO:0043392","GO:0060334","GO:0051572","GO:0016925","GO:0043433","GO:0035186","GO:0086004","GO:0030578","GO:1902260","GO:0045944","GO:0045759","GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412","GO:0019731","GO:0002227"]},{"accession":"XP_026693309.2","go_terms":["GO:0006777","GO:0016236","GO:0034727","GO:1990592","GO:0021764","GO:0002143","GO:0032447","GO:0045116","GO:0018192","GO:0006501","GO:0032258","GO:0009229","GO:0009228","GO:0050832","GO:2000220","GO:0044805","GO:0045892","GO:0061504","GO:0016925","GO:0007113","GO:0000422","GO:0051726"]},{"accession":"XP_078481973.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_078494627.1","go_terms":["GO:0006310","GO:0046718","GO:0019076","GO:0075713","GO:0075732","GO:0015074","GO:0006508","GO:0039651","GO:0039657","GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412"]},{"accession":"XP_002128871.2","go_terms":["GO:0034727","GO:0000226","GO:0034198","GO:0010940","GO:0010040","GO:0034629","GO:0040024","GO:0008625","GO:0006888","GO:0000045","GO:0097352","GO:0032258","GO:0071211","GO:0070301","GO:0010288","GO:0061709","GO:0006915","GO:0044805","GO:0043278","GO:0071280","GO:0000422","GO:0070257"]},{"accession":"XP_002132081.2","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_078482615.1","go_terms":["GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412","GO:0007023","GO:0031117","GO:0034126","GO:0014889","GO:0031122","GO:0048936"]},{"accession":"XP_078485160.1","go_terms":[]},{"accession":"XP_078492719.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]},{"accession":"XP_078488349.1","go_terms":["GO:0046902","GO:0070940","GO:0030150","GO:1903740","GO:2000134","GO:0010867","GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412"]}],"graph":[["XP_078494627.1","XP_002124862.2",0.933],["XP_078494627.1","XP_002128871.2",0.969],["XP_078494627.1","XP_002129578.1",0.99],["XP_078494627.1","XP_002129622.1",0.951],["XP_078494627.1","XP_002132081.2",0.969],["XP_078494627.1","XP_009859868.2",0.973],["XP_078494627.1","XP_026689474.2",0.984],["XP_078494627.1","XP_026689629.2",0.986],["XP_078494627.1","XP_026693309.2",0.87],["XP_078494627.1","XP_078481973.1",0.933],["XP_078494627.1","XP_078482615.1",0.977],["XP_078494627.1","XP_078485160.1",0.987],["XP_078494627.1","XP_078488349.1",0.99],["XP_078494627.1","XP_078490067.1",0.991],["XP_078494627.1","XP_078492719.1",0.96],["XP_078494627.1","XP_078494930.1",0.98],["XP_078488349.1","XP_002124862.2",0.923],["XP_078488349.1","XP_002128871.2",0.954],["XP_078488349.1","XP_002129578.1",0.987],["XP_078488349.1","XP_002129622.1",0.964],["XP_078488349.1","XP_002132081.2",0.972],["XP_078488349.1","XP_009859868.2",0.988],["XP_078488349.1","XP_026689474.2",0.989],["XP_078488349.1","XP_026689629.2",0.959],["XP_078488349.1","XP_026693309.2",0.863],["XP_078488349.1","XP_078481973.1",0.945],["XP_078488349.1","XP_078482615.1",0.926],["XP_078488349.1","XP_078485160.1",0.984],["XP_078488349.1","XP_078494930.1",0.972],["XP_078488349.1","XP_078492719.1",0.905],["XP_078488349.1","XP_078490067.1",0.989],["XP_002129578.1","XP_002124862.2",0.943],["XP_002129578.1","XP_078481973.1",0.959],["XP_002129578.1","XP_026689629.2",0.983],["XP_002129578.1","XP_026693309.2",0.969],["XP_002129578.1","XP_026689474.2",0.985],["XP_002129578.1","XP_009859868.2",0.978],["XP_002129578.1","XP_002128871.2",0.921],["XP_002129578.1","XP_002129622.1",0.895],["XP_002129578.1","XP_002132081.2",0.972],["XP_002129578.1","XP_078485160.1",0.979],["XP_002129578.1","XP_078482615.1",0.908],["XP_002129578.1","XP_078494930.1",0.929],["XP_002129578.1","XP_078492719.1",0.982],["XP_002129578.1","XP_078490067.1",0.985],["XP_078494930.1","XP_002124862.2",0.959],["XP_078494930.1","XP_002128871.2",0.909],["XP_078494930.1","XP_002129622.1",0.895],["XP_078494930.1","XP_002132081.2",0.97],["XP_078494930.1","XP_009859868.2",0.976],["XP_078494930.1","XP_026689474.2",0.978],["XP_078494930.1","XP_026689629.2",0.975],["XP_078494930.1","XP_026693309.2",0.936],["XP_078494930.1","XP_078481973.1",0.977],["XP_078494930.1","XP_078482615.1",0.962],["XP_078494930.1","XP_078485160.1",0.968],["XP_078494930.1","XP_078490067.1",0.962],["XP_078494930.1","XP_078492719.1",0.964],["XP_078490067.1","XP_002124862.2",0.972],["XP_078490067.1","XP_002128871.2",0.985],["XP_078490067.1","XP_002129622.1",0.95],["XP_078490067.1","XP_002132081.2",0.976],["XP_078490067.1","XP_009859868.2",0.987],["XP_078490067.1","XP_026689474.2",0.989],["XP_078490067.1","XP_026689629.2",0.981],["XP_078490067.1","XP_026693309.2",0.909],["XP_078490067.1","XP_078481973.1",0.981],["XP_078490067.1","XP_078482615.1",0.952],["XP_078490067.1","XP_078485160.1",0.982],["XP_078490067.1","XP_078492719.1",0.966],["XP_078485160.1","XP_002124862.2",0.838],["XP_078485160.1","XP_002128871.2",0.949],["XP_078485160.1","XP_002129622.1",0.734],["XP_078485160.1","XP_002132081.2",0.951],["XP_078485160.1","XP_009859868.2",0.98],["XP_078485160.1","XP_026689474.2",0.967],["XP_078485160.1","XP_026689629.2",0.986],["XP_078485160.1","XP_026693309.2",0.987],["XP_078485160.1","XP_078481973.1",0.896],["XP_078485160.1","XP_078482615.1",0.825],["XP_078485160.1","XP_078492719.1",0.907],["XP_009859868.2","XP_002124862.2",0.923],["XP_009859868.2","XP_002128871.2",0.964],["XP_009859868.2","XP_002129622.1",0.972],["XP_009859868.2","XP_002132081.2",0.964],["XP_009859868.2","XP_078481973.1",0.902],["XP_009859868.2","XP_026689629.2",0.972],["XP_009859868.2","XP_026693309.2",0.965],["XP_009859868.2","XP_026689474.2",0.987],["XP_009859868.2","XP_078482615.1",0.965],["XP_009859868.2","XP_078492719.1",0.982],["XP_026689629.2","XP_002124862.2",0.923],["XP_026689629.2","XP_002128871.2",0.98],["XP_026689629.2","XP_002129622.1",0.844],["XP_026689629.2","XP_002132081.2",0.97],["XP_026689629.2","XP_026689474.2",0.982],["XP_026689629.2","XP_078481973.1",0.962],["XP_026689629.2","XP_026693309.2",0.959],["XP_026689629.2","XP_078482615.1",0.958],["XP_026689629.2","XP_078492719.1",0.93],["XP_026689474.2","XP_002124862.2",0.929],["XP_026689474.2","XP_002128871.2",0.977],["XP_026689474.2","XP_002129622.1",0.957],["XP_026689474.2","XP_002132081.2",0.969],["XP_026689474.2","XP_026693309.2",0.938],["XP_026689474.2","XP_078481973.1",0.963],["XP_026689474.2","XP_078482615.1",0.965],["XP_026689474.2","XP_078492719.1",0.965],["XP_002132081.2","XP_002124862.2",0.903],["XP_002132081.2","XP_002128871.2",0.934],["XP_002132081.2","XP_002129622.1",0.946],["XP_002132081.2","XP_026693309.2",0.83],["XP_002132081.2","XP_078481973.1",0.942],["XP_002132081.2","XP_078482615.1",0.883],["XP_002132081.2","XP_078492719.1",0.949],["XP_078481973.1","XP_002124862.2",0.95],["XP_078481973.1","XP_002128871.2",0.97],["XP_078481973.1","XP_002129622.1",0.987],["XP_078481973.1","XP_026693309.2",0.914],["XP_078481973.1","XP_078482615.1",0.981],["XP_078481973.1","XP_078492719.1",0.971],["XP_002124862.2","XP_026693309.2",0.948],["XP_002124862.2","XP_002128871.2",0.913],["XP_002124862.2","XP_002129622.1",0.947],["XP_002124862.2","XP_078482615.1",0.805],["XP_002124862.2","XP_078492719.1",0.915],["XP_002128871.2","XP_026693309.2",0.982],["XP_002128871.2","XP_002129622.1",0.738],["XP_002128871.2","XP_078482615.1",0.948],["XP_002128871.2","XP_078492719.1",0.97],["XP_002129622.1","XP_026693309.2",0.98],["XP_002129622.1","XP_078482615.1",0.943],["XP_002129622.1","XP_078492719.1",0.951],["XP_026693309.2","XP_078482615.1",0.987],["XP_026693309.2","XP_078492719.1",0.909],["XP_078482615.1","XP_078492719.1",0.987]],"all_go_terms":{"GO:0010637":5,"GO:1901340":5,"GO:0006357":5,"GO:0010216":5,"GO:0014070":5,"GO:0071816":5,"GO:0008625":4,"GO:0090367":1,"GO:1904021":5,"GO:0030474":5,"GO:0042993":1,"GO:0035973":5,"GO:0000423":5,"GO:0010636":5,"GO:0010763":1,"GO:1902283":5,"GO:0006289":5,"GO:0016925":6,"GO:0061084":1,"GO:0016579":9,"GO:0051865":5,"GO:0031397":1,"GO:0010228":1,"GO:1904378":5,"GO:0046827":1,"GO:1905366":5,"GO:1903215":1,"GO:0032435":1,"GO:1904049":5,"GO:0090083":1,"GO:0000028":5,"GO:1903061":1,"GO:0021888":5,"GO:0097201":1,"GO:1901799":5,"GO:0070842":5,"GO:0010664":1,"GO:1902176":1,"GO:2001145":1,"GO:0051496":1,"GO:0045648":5,"GO:0071260":1,"GO:0000753":5,"GO:0030433":5,"GO:0017085":5,"GO:1903071":5,"GO:1900186":5,"GO:0071364":1,"GO:1903265":5,"GO:0097192":1,"GO:1901097":5,"GO:0097237":5,"GO:1902236":5,"GO:0002109":5,"GO:0034140":5,"GO:0006412":5,"GO:0097178":1,"GO:0061321":1,"GO:0006517":5,"GO:0033132":5,"GO:0051436":4,"GO:0009651":4,"GO:0031146":4,"GO:0002862":4,"GO:0051437":4,"GO:0080129":4,"GO:0043488":4,"GO:0010043":4,"GO:0090090":4,"GO:0050852":4,"GO:0002479":4,"GO:0038095":4,"GO:0031145":4,"GO:0006521":4,"GO:0010363":4,"GO:0002223":4,"GO:0016032":4,"GO:0033209":4,"GO:0046686":4,"GO:0090263":4,"GO:0060071":4,"GO:0061418":4,"GO:0010972":4,"GO:0010499":4,"GO:0038061":4,"GO:0010950":4,"GO:0032355":1,"GO:0051403":1,"GO:0099641":1,"GO:0070141":1,"GO:0031109":1,"GO:0030308":1,"GO:0070309":1,"GO:1905907":1,"GO:0009408":1,"GO:0050821":1,"GO:0032463":1,"GO:1900034":1,"GO:0006936":1,"GO:0071480":1,"GO:2000378":1,"GO:0042542":1,"GO:0032387":1,"GO:0009644":1,"GO:0007568":1,"GO:1990592":2,"GO:0033146":1,"GO:0044805":4,"GO:0010940":3,"GO:0000045":3,"GO:0071280":3,"GO:0070257":3,"GO:0000226":3,"GO:0010288":3,"GO:0006915":3,"GO:0061709":3,"GO:0006501":3,"GO:0035096":2,"GO:0006888":3,"GO:0070301":3,"GO:0032258":4,"GO:0097352":3,"GO:0040024":3,"GO:0043278":3,"GO:0000422":4,"GO:0061723":2,"GO:0071211":3,"GO:0034198":3,"GO:0010040":3,"GO:0034629":3,"GO:0034727":4,"GO:0010286":1,"GO:0043433":1,"GO:0034126":2,"GO:0045944":1,"GO:0002227":1,"GO:0051572":1,"GO:0032436":1,"GO:1901896":1,"GO:0030578":1,"GO:0045759":1,"GO:0035186":1,"GO:0060334":1,"GO:1902260":1,"GO:0071276":1,"GO:0086004":1,"GO:0090204":1,"GO:0043392":1,"GO:0070911":1,"GO:0019731":1,"GO:0006777":1,"GO:0007113":1,"GO:2000220":1,"GO:0051726":1,"GO:0009229":1,"GO:0045892":1,"GO:0009228":1,"GO:0018192":1,"GO:0050832":1,"GO:0002143":1,"GO:0061504":1,"GO:0021764":1,"GO:0016236":1,"GO:0045116":1,"GO:0032447":1,"GO:0006508":2,"GO:0006310":1,"GO:0046718":1,"GO:0075713":1,"GO:0039651":1,"GO:0015074":1,"GO:0075732":1,"GO:0039657":1,"GO:0019076":1,"GO:0007023":1,"GO:0031122":1,"GO:0031117":1,"GO:0048936":1,"GO:0014889":1,"GO:0001957":1,"GO:0071888":1,"GO:1903146":1,"GO:0042493":1,"GO:0043129":1,"GO:0043418":1,"GO:0034769":1,"GO:1990236":1,"GO:0009636":1,"GO:1903955":1,"GO:0035593":1,"GO:0010815":1,"GO:0001913":1,"GO:0097067":1,"GO:0051603":1,"GO:0046697":1,"GO:0060448":1,"GO:0007614":1,"GO:0030574":1,"GO:0010839":1,"GO:0060441":1,"GO:2000179":1,"GO:1990237":1,"GO:0010813":1,"GO:0045453":1,"GO:0050790":1,"GO:0070940":1,"GO:0010867":1,"GO:1903740":1,"GO:2000134":1,"GO:0046902":1,"GO:0030150":1},"recipe_readded":[]}