[{"hash":"1215778233527486429","title":"Embryonic Organ Development","description":"This cluster is enriched for developmental processes across multiple organs, including heart development, embryonic heart tube left/right patterning, skeletal system development, pancreas development, midbrain development, and retinal ganglion cell axon guidance, suggesting a coordinated embryonic organogenesis program. A label of transcriptional regulation (negative regulation of transcription by RNA polymerase II) may reflect regulatory control mechanisms active during development, while some immune-related terms (complement activation, LPS response) could be less central annotations or multifunctional roles. Overall, the dominant theme appears to be embryonic organ development across tissues.","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0030901","count":6},{"id":"GO:0055114","count":5},{"id":"GO:0031290","count":5},{"id":"GO:0031018","count":5}]},{"hash":"950115654586720219","title":"Ubiquitin-Regulated Circadian and Development Signaling","description":"The top GO terms cluster around ubiquitin-dependent protein degradation and regulation of circadian rhythm, with additional signals pointing to development in nervous system and muscle, along with receptor signaling. This suggests a theme where protein turnover and circadian control intersect with broad signaling and developmental processes across tissues, despite some outlier terms.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":23},{"id":"GO:0042752","count":18},{"id":"GO:0051260","count":16},{"id":"GO:0050853","count":15},{"id":"GO:0007399","count":14}]},{"hash":"58481928912670709","title":"Membrane Ion Transporters and Vesicle Loading","description":"These GO terms cluster around transport across membranes, including ions (sodium, potassium, phosphate), sialic acid, and xenobiotics, plus neurotransmitter loading into synaptic vesicles, pointing to a group of membrane transporters and vesicle trafficking proteins; development- or heart-specific terms may reflect contextual annotations but are secondary.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0098907","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0006004","count":3}]},{"hash":"1075501884436598428","title":"Unknown","description":"The terms span development (outflow tract morphogenesis, in utero embryonic development), vascular/immune processes (angiogenesis, complement activation, MAC regulation), and general cellular machinery (ubiquitination, spliceosome assembly, translation) but do not share a single coherent function; with no edges connecting the proteins, there is no clear theme to name beyond Unknown.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003151","count":3},{"id":"GO:0050908","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0006957","count":3},{"id":"GO:0006958","count":3}]},{"hash":"1574949845808432147","title":"Neural Development and Synaptic Signaling","description":"The cluster is dominated by neural-related functions: retina development, regulation of neuronal signaling (NMDA receptor activity), and synaptic processes (vesicle exocytosis and localization to synapse). Presence of xenobiotic response and choline metabolism aligns with neuronal metabolism and protection. An outlier term (osteoblast development) does not negate the overall neural/synaptic theme.","confidence":"High","size":29,"edges":403,"triangles":3573,"max_degree":28,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":13},{"id":"GO:0002087","count":12},{"id":"GO:0002076","count":12},{"id":"GO:2000310","count":10},{"id":"GO:0042493","count":10}]},{"hash":"855036067722501325","title":"Blood coagulation and vascular remodeling","description":"Most terms point to hemostasis and vascular remodeling: blood coagulation, positive regulation of fibrinolysis, and negative regulation of endothelial cell chemotaxis, plus tissue remodeling. Obsolete Wnt/Notch and developmental terms appear as background annotations but do not define the core theme. Together, they suggest a cluster centered on coagulation and vascular remodeling.","confidence":"High","size":29,"edges":18,"triangles":1,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":15},{"id":"GO:0045746","count":10},{"id":"GO:0048771","count":8},{"id":"GO:0044332","count":8},{"id":"GO:0032496","count":8}]},{"hash":"1538491215667958489","title":"Translation initiation control and intracellular trafficking","description":"This cluster is enriched for translation-related terms (formation of translation preinitiation complex; regulation of translational initiation; IRES-dependent viral translational initiation) and RNA processing (mRNA splicing via spliceosome), complemented by vesicle trafficking between ER and Golgi and endocytosis, plus protein turnover (proteasome-mediated ubiquitin-dependent proteolysis). The combination suggests coordination between RNA processing/translation and intracellular transport/quality control.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0001731","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0006890","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0043473","count":3}]},{"hash":"406704224622956369","title":"Unknown","description":"The top GO terms are highly diverse (ubiquitin-dependent protein catabolic process, circadian rhythm regulation, nervous system and skeletal muscle development, B cell signaling, plant glucosinolate metabolism, swimming, renal ion transport), with no single coherent biological theme tying all proteins together. Although ubiquitin-proteasome and circadian terms appear, the mix across development, signaling, and metabolism makes a meaningful, specific label unlikely. Confidence: None","confidence":"","size":29,"edges":5,"triangles":1,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":20},{"id":"GO:0042752","count":16},{"id":"GO:0007399","count":14},{"id":"GO:0050853","count":12},{"id":"GO:0031397","count":12}]},{"hash":"1725541399867422508","title":"Innate antiviral immune response","description":"The top GO terms are dominated by innate immune defense and antiviral-related processes (innate immune response, defense response to virus, cellular response to exogenous dsRNA), indicating a core theme of antiviral innate immunity. Some terms like GPCR signaling, histone methylation, and gibberellin signaling appear as noise or cross-species annotations, but the prevalent signal points to innate immune defense against viruses.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":8},{"id":"GO:0008277","count":8},{"id":"GO:0009938","count":8},{"id":"GO:2001162","count":7},{"id":"GO:0051301","count":7}]},{"hash":"531364160668252437","title":"Thermogenesis and Immune Response","description":"This cluster is dominated by terms tied to temperature-driven metabolism (cellular response to temperature stimulus, diet-induced thermogenesis, eating behavior), suggesting a core theme of thermogenic/metabolic regulation. The presence of immune-related terms (interleukin-12 production, TNF regulation, CD8+ T cell differentiation, xenobiotic response) indicates notable immune signaling involvement within the same protein set, supporting a combined Thermogenesis and Immune Response theme. ","confidence":"Medium","size":29,"edges":6,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":9},{"id":"GO:0002024","count":9},{"id":"GO:0019233","count":9},{"id":"GO:0042391","count":7},{"id":"GO:0032720","count":6}]},{"hash":"431249132007066457","title":"Developmental Signaling and Regulation","description":"GO terms in this cluster center on developmental processes (heart and hippocampus development) and signaling pathways (T cell receptor and ephrin receptor signaling), with accompanying regulatory processes like ubiquitination, cytoskeleton remodeling, and cell cycle control. The combination suggests a broad theme of development-associated signaling and regulation rather than a single tissue-specific function. Confidence: Medium","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":7},{"id":"GO:0050852","count":6},{"id":"GO:0021766","count":6},{"id":"GO:2001275","count":6},{"id":"GO:0043366","count":5}]},{"hash":"1366704774081781695","title":"Neural development and axon-domain localization","description":"The top GO terms cluster around nervous system development and function, including neurogenesis, sensory perception of sound, and protein localization to paranode/juxtaparanode regions of axons, with apoptosis-related terms also present. While metabolic signaling (insulin signaling and glucose transport) appears, the dominant themes point to neural development and axonal organization, suggesting the proteins function together in neuronal development and axon domain localization. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0071205","count":4},{"id":"GO:0002175","count":4},{"id":"GO:0008286","count":3}]},{"hash":"147729645193637284","title":"Axon guidance and myelination","description":"The proteins are enriched for neural development processes: axon extension and fasciculation, paranodal junctions, synapse assembly, and myelination, indicating a cohesive role in axon pathfinding and nerve fiber maturation (with some related sensory system involvement). ","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":12},{"id":"GO:0030913","count":11},{"id":"GO:0007157","count":11},{"id":"GO:0042552","count":11},{"id":"GO:0007413","count":11}]},{"hash":"1176414673221220576","title":"Rho/Rac Signaling and Morphogenesis","description":"This cluster centers on regulation of Rho and Rac GTPase signaling, which points to small GTPase\u2013driven cytoskeletal dynamics. The presence of additional terms linked to Wnt signaling and various morphogenesis and development processes (nerve branching, skeletal muscle development) suggests a broader developmental signaling module in which Rho/Rac pathways influence cell shape, movement, and tissue patterning. Confidence: Medium","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0051321","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0009737","count":2},{"id":"GO:0048755","count":2}]},{"hash":"1621799552183397184","title":"Skeletal Muscle Development and Sarcomere Organization","description":"The Top Terms include sarcomere organization and skeletal muscle tissue development, with swimming also pointing to muscle-related function, suggesting the core signal is muscle structure and development; a few terms (immune signaling, dendritic cell differentiation) seem peripheral or noisy, but do not outweigh the muscle-related theme.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0045214","count":4},{"id":"GO:0007339","count":3},{"id":"GO:2001200","count":3}]},{"hash":"905171333933228466","title":"Neuronal signaling and synapse assembly","description":"The top terms cluster primarily around nervous system development and synapse assembly, with recurrent signaling through ERK cascades and GTPases, plus ubiquitin-regulated protein turnover. While immune and sarcomere-related terms appear, the dominant theme points to neural signal transduction and synaptic organization with regulatory ubiquitination. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0070374","count":3}]},{"hash":"86071424860407663","title":"Mitotic progression and ubiquitin signaling","description":"The dominant GO terms point to mitosis-related processes (mitotic cell cycle, mitotic spindle assembly, regulation of cytokinesis) and ubiquitin-mediated regulation (protein polyubiquitination, monoubiquitination), with supporting signals from transcription and apoptotic regulation and broader proliferation pathways (Wnt and NF-kappaB). This suggests a cohesive theme around controlling cell division through ubiquitin-dependent regulatory mechanisms.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0000209","count":3}]},{"hash":"2119128533237352698","title":"Neural Sensory Connectivity and Adhesion","description":"This cluster centers on neural junctions and connectivity (paranodal and septate junction assembly, axonal fasciculation, excitatory postsynaptic potential) and cell adhesion (heterophilic adhesion, receptor internalization), with sensory system themes (visual perception, detection of sound, retina development). Together these terms suggest proteins involved in establishing and modulating neural connections and sensory organ development, with some junction-related biology that can be common to neural and epithelial contexts.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030913","count":8},{"id":"GO:0090528","count":7},{"id":"GO:0050910","count":7},{"id":"GO:0001867","count":6},{"id":"GO:0007601","count":6}]},{"hash":"2219429494394939253","title":"RNA processing and transcription regulation","description":"This cluster is dominated by GO terms tied to RNA biology, notably negative regulation of transcription by RNA polymerase II, 7-methylguanosine mRNA capping, and tRNA methylation, suggesting a common theme of RNA processing and gene-expression regulation. While other terms touch on stress responses and metabolism, the RNA-centric terms provide the strongest unifying signal.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0055114","count":6},{"id":"GO:0017000","count":5},{"id":"GO:0030488","count":5},{"id":"GO:0030901","count":5}]},{"hash":"918964659065086235","title":"Innate Immunity and Morphogenesis","description":"This cluster shows strong signals for innate immune processes (innate immune response, defense against virus, response to lipopolysaccharide) alongside developmental morphogenesis terms (axon extension, axonal fasciculation, metanephric tubule morphogenesis, lymph vessel morphogenesis) and a note on ubiquitination. The proteins seem to integrate immune signaling with tissue development across multiple organ systems, suggesting a broader role in regulation rather than a single, narrow function.","confidence":"Medium","size":28,"edges":35,"triangles":15,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0048846","count":4},{"id":"GO:0007413","count":4},{"id":"GO:0036303","count":4},{"id":"GO:0071222","count":4}]},{"hash":"253726676916788501","title":"Mitochondrial Transport and Fission","description":"The top GO terms cluster around mitochondrial functions: mitochondrial membrane fission and mitochondrial ATP transmembrane transport dominate, with several transport terms for vitamins/cofactors (thiamine pyrophosphate, pyridoxal phosphate, glycine) that feed mitochondrial metabolism. In addition, insulin signaling, fatty acid response, and liver regeneration contexts suggest metabolic regulation linked to mitochondria. The obsolete mitochondrial genome maintenance term reinforces a mitochondrial-centric theme. Overall, these proteins appear tied to mitochondria-focused transport, energy metabolism, and dynamics (fission).","confidence":"High","size":28,"edges":11,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0032869","count":7},{"id":"GO:0030974","count":6},{"id":"GO:0000002","count":6},{"id":"GO:0070542","count":6},{"id":"GO:0036233","count":6}]},{"hash":"1461587348156113547","title":"Developmental gene regulation and chromatin modification","description":"This cluster centers on GO terms tied to development (skin and multicellular development), transcriptional control (DNA-templated transcription), RNA processing/splicing, and histone methylation, suggesting proteins involved in regulating gene expression during development through chromatin state and RNA processing.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043588","count":5},{"id":"GO:0007338","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0051568","count":4},{"id":"GO:0000398","count":4}]},{"hash":"296931695536596860","title":"Tissue development and immune activation","description":"Based on the Top Terms, the cluster centers on tissue development, morphogenesis (skin, skeletal system), and cell adhesion, with accompanying immune-related terms (macrophage activation, defense against Gram-positive bacteria). While there are a few miscellaneous terms (mechanical stimulus, GPCR signaling, SA node activity), the dominant theme is developmental/tissue remodeling with an immune component, justifying this label.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071260","count":4},{"id":"GO:0042116","count":4},{"id":"GO:0043588","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0008284","count":3}]},{"hash":"2187401594236982415","title":"Ubiquitin-Dependent Degradation and Antiviral Defense","description":"This cluster is dominated by ubiquitin-dependent protein catabolic process, autophagy, and ERAD, together with innate immune and antiviral defense terms. The co-occurrence of ubiquitin-mediated turnover with NF-kappaB signaling and antiviral defense suggests a module centered on protein quality control linked to immune activation against viruses. Some terms on endocytosis and development indicate broader cellular regulation, but the core theme remains ubiquitin-dependent turnover in immune defense.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0045087","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0006914","count":4},{"id":"GO:2000312","count":3}]},{"hash":"2298437266069850143","title":"ECM Adhesion and Remodeling","description":"The top GO terms cluster around extracellular matrix interactions: integrin-mediated signaling, cell-matrix adhesion (including calcium-independent adhesion), hyaluronan metabolism, regulation of metalloproteinase activity, and modulation of ECM assembly/disassembly, plus substrate-dependent cell migration and dendrite regeneration. This points to a cohesive module governing how cells attach to and remodel the ECM, with implications for migration and structural remodeling.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0007229","count":7},{"id":"GO:0030212","count":6},{"id":"GO:1905050","count":6},{"id":"GO:0070208","count":6},{"id":"GO:0007161","count":5}]},{"hash":"441785161861144469","title":"Vertebrate embryonic organogenesis","description":"This cluster is dominated by GO terms related to vertebrate embryonic development and organ formation, including placenta, midbrain, eye, somite/palate development, and neural crest derivatives like the trigeminal ganglion, with additional notes on fertilization and gonad development. The recurring theme is coordinated development of multiple organs and tissues during vertebrate embryogenesis, suggesting a cohesive functional category of organogenesis regulators. High","confidence":"","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0007338","count":6},{"id":"GO:0001890","count":6},{"id":"GO:0030901","count":5},{"id":"GO:0061551","count":5}]},{"hash":"1161104067322812113","title":"Mitochondrial translation and ribosome assembly","description":"The top terms cluster around translation (both cytoplasmic and mitochondrial) and ribosome assembly, with additional mitochondrial functions related to energy production (proton motive force-driven ATP synthesis and complex II assembly). The dominant theme is protein synthesis machinery associated with mitochondria and ribosome biogenesis, making this label representative. A single outlier term about neural development appears incidental.","confidence":"High","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0032543","count":3},{"id":"GO:0034553","count":2},{"id":"GO:0015986","count":2},{"id":"GO:0021762","count":2}]},{"hash":"43502040465988287","title":"Innate Immunity and Tissue Remodeling","description":"The cluster is rich in GO terms for complement activation via lectin and classical pathways, defense against Gram-positive bacteria, and phagolysosome assembly, indicating core innate immune activity. Additional terms for plasminogen activation, positive regulation of angiogenesis, and multicellular organism growth suggest concurrent tissue remodeling and vascular changes often associated with inflammation. Less cohesive terms like midbrain development and single fertilization may reflect pleiotropic roles of some proteins, but the dominant signal is innate immune response and remodeling.","confidence":"High","size":28,"edges":3,"triangles":0,"max_degree":3,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0001867","count":11},{"id":"GO:0007338","count":10},{"id":"GO:0030901","count":10},{"id":"GO:0000122","count":10},{"id":"GO:0006958","count":10}]},{"hash":"2191573342715397722","title":"Immune signaling and transcriptional regulation","description":"The cluster is dominated by GO terms tied to immune activation and transcriptional control, including DNA-templated transcription, DNA replication, LPS response, GM-CSF response, T cell receptor signaling, and chemotaxis, suggesting coordinated signaling and gene regulation in immune cells. Additional terms for keratinocyte differentiation and Hippo signaling hint at broader roles in epidermal development and proliferation, but the strongest recurrent theme centers on immune signaling intertwined with transcriptional regulation. ","confidence":"Medium","size":28,"edges":79,"triangles":88,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":24},{"id":"GO:0071222","count":23},{"id":"GO:0006260","count":23},{"id":"GO:0097011","count":23},{"id":"GO:0050852","count":23}]},{"hash":"2089667137497583502","title":"Neuronal development and axon guidance","description":"The cluster is dominated by neural-development terms: nervous system development, axonal fasciculation, synapse assembly, myelination, and guidance-related processes (e.g., chemorepulsion of migrating interneurons, otolith morphogenesis), suggesting a cohesive theme of neuron formation, connectivity, and maturation. An innate immune term appears but does not override the neuronal focus. ","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":9},{"id":"GO:0045087","count":7},{"id":"GO:0014068","count":7},{"id":"GO:0071372","count":6},{"id":"GO:0007399","count":5}]},{"hash":"188145899504061023","title":"Unknown","description":"The top terms include RNA modification and transcription alongside developmental and biosynthetic processes, stress responses, and retinal/brain development terms. With no observed edges tying the proteins into a single cohesive function, there isn\u2019t a clear common theme to label a specific cluster function.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0036265","count":7},{"id":"GO:0006351","count":5},{"id":"GO:0007420","count":5},{"id":"GO:0009236","count":5},{"id":"GO:0009102","count":5}]},{"hash":"1403256202791619133","title":"Mitochondrial protein import, translation, and copper homeostasis","description":"Dominant terms point to mitochondrial protein handling (import into matrix, translation, folding) and copper-dependent assembly of respiratory chain complexes, supported by copper homeostasis and redox balance; iron-sulfur cluster maturation is also implicated. A single outlier term (oocyte construction) may be noise. Overall, this suggests a module for mitochondrial protein synthesis and copper-mediated maturation.","confidence":"High","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0034396","count":2},{"id":"GO:0006457","count":2},{"id":"GO:0097428","count":2}]},{"hash":"1735230466926650672","title":"Redox-Linked Transcription Regulation","description":"The cluster centers on transcription-related GO terms (DNA-templated transcription; negative regulation of RNA polymerase II) and redox/oxidative stress functions (cell redox homeostasis; cellular response to oxidative stress; protein deglutathionylation), suggesting proteins that modulate gene expression in response to redox changes. A secondary theme around glycan biosynthesis is present but less cohesive, making the redox-regulated transcription interpretation the most representative.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006486","count":5},{"id":"GO:0045454","count":4},{"id":"GO:0010493","count":4},{"id":"GO:0045494","count":3},{"id":"GO:0000122","count":3}]},{"hash":"622250421890643570","title":"Developmental Regulation and Cell Cycle","description":"The proteins are enriched for developmental processes across multiple tissues (retina, spinal cord, male gonad) and for core cell-cycle activities (cell proliferation, mitotic sister chromatid segregation, microtubule-based movement). Additional terms like RNA guanine-N7 methylation and positive regulation of GTPase activity suggest broader regulatory roles that coordinate growth, development, and division. Together, these terms point to a theme of developmental regulation coupled with cell-cycle control rather than a single tissue-specific function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0060041","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0008284","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0036265","count":3}]},{"hash":"785626579156149421","title":"Ubiquitin-regulated proteostasis and autophagy","description":"These proteins cluster around protein quality control and degradation pathways, with GO terms for sumoylation, deubiquitination, and ubiquitin-dependent ERAD, plus several autophagy-related processes (mitophagy, nucleophagy, Cvt, piecemeal microautophagy). The combination suggests a module focused on proteostasis through both ubiquitin-mediated pathways and selective autophagy, justifying the label.","confidence":"High","size":28,"edges":315,"triangles":2014,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":9},{"id":"GO:0016579","count":8},{"id":"GO:0030433","count":7},{"id":"GO:0044805","count":6},{"id":"GO:0032258","count":6}]},{"hash":"1613794212186207974","title":"Immune Cell Development and Signaling","description":"The top GO terms cluster around immune/hematopoietic processes: hemopoiesis; cellular responses to GM-CSF and IL-7; desensitization of GPCR signaling; plus apoptosis and cell migration. While there are broader development terms (nervous system development, placental differentiation), the majority support a theme of hematopoietic/immune development and cytokine signaling. Thus, the cluster is best described as immune cell development and signaling.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0016477","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0097011","count":7},{"id":"GO:0006915","count":6},{"id":"GO:0010765","count":6}]},{"hash":"121045763024405036","title":"Glycinergic Neurotransmission and Neural Development","description":"The top terms emphasize glycine-related synaptic activity (glycine secretion, import, and regulation of glycinergic transmission) along with other neurotransmitter processes (dopamine uptake, serotonin secretion). Additionally, development-related terms (thalamus development, perineurial glial growth, adenohypophysis development) indicate a broader neural development context. Together, these suggest a cluster focused on glycinergic signaling within neural development.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042066","count":3},{"id":"GO:0015820","count":2},{"id":"GO:0051583","count":2},{"id":"GO:0021984","count":2},{"id":"GO:1905847","count":2}]},{"hash":"563059457020376767","title":"Neurodevelopment and cell-cycle\u2013linked proliferation","description":"The top GO terms strongly couple neural development (nervous system development, neural tube closure, labyrinthine layer development) with core nuclear processes (DNA replication, DNA-templated transcription, mitotic cell cycle), pointing to proteins involved in proliferative neurodevelopment. Additional terms for VEGF signaling and immune/stress responses (LPS/Gram-positive defense, ER-stress\u2013related apoptosis) suggest accompanying supportive signaling, but the main theme remains neurodevelopment coupled with cell-cycle\u2013driven growth.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0060711","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0007399","count":4}]},{"hash":"1233131748631455619","title":"Nuclear ribosome import/export and RNA processing","description":"The cluster is strongly enriched for GO terms about importing ribosomal proteins and exporting ribosomal subunits into and out of the nucleus, indicating a core role in nuclear ribosome biogenesis and transport. Additional terms for DNA-templated transcription and RNA methylation suggest nuclear RNA processing accompanying ribosome assembly.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006607","count":4},{"id":"GO:0006656","count":4},{"id":"GO:0000056","count":4},{"id":"GO:0036265","count":4},{"id":"GO:0060188","count":3}]},{"hash":"1509359712420438566","title":"Neural Plasticity and Behavior","description":"Top terms center on synaptic plasticity (long-term potentiation/depression) and behavioral processes (social behavior, vocalization), suggesting a cluster of proteins involved in neural signaling and behavior modulation. While immune-related terms are present, the dominant signal points to neural connectivity and plasticity underlying social and vocal behaviors, with supporting roles in cytoskeletal dynamics and signaling pathways.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0046847","count":3},{"id":"GO:0001771","count":3},{"id":"GO:0035176","count":3},{"id":"GO:0060124","count":3}]},{"hash":"1394056978132968774","title":"Innate antiviral immunity and ubiquitin-dependent protein turnover","description":"The top GO terms cluster around antiviral innate responses (dsRNA sensing, type I interferon signaling, innate immunity) and protein quality control via ubiquitin-dependent degradation (ERAD, ubiquitin-dependent catabolic processes). This suggests a cohesive group of proteins involved in antiviral defense and protein turnover, despite some miscellaneous terms like cell division and plant hormone signaling. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0009938","count":3},{"id":"GO:0046902","count":2}]},{"hash":"1146262412165132933","title":"Inflammation and pain signaling with vascular remodeling","description":"This cluster prominently features inflammatory chemokine production (CXCL1, MIP-1\u03b1) and pain perception/response, along with vascular remodeling signals (endothelial cell delamination) and neuroendocrine involvement (vasopressin secretion). Thermoception and heat response further support a theme of sensory/inflammatory signaling linked to vascular changes. Some terms related to brown fat differentiation appear ancillary, reinforcing a primary focus on inflammation and vascular remodeling.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000340","count":4},{"id":"GO:0071642","count":4},{"id":"GO:0097497","count":4},{"id":"GO:0050968","count":4},{"id":"GO:0048265","count":4}]},{"hash":"1127461229202876854","title":"Vertebrate tissue development and morphogenesis","description":"The cluster shows strong signals for multicellular organism development, retina, skin, and skeletal system development, plus proliferation and transcription regulation, indicating a cohesive role in vertebrate tissue formation and morphogenesis. The absence of edges suggests these proteins may participate in a developmental program rather than a single complex, with some immune or hypoxia-related terms likely reflecting context during development.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":7},{"id":"GO:0060041","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0001501","count":6}]},{"hash":"1439063277804640697","title":"Signaling and cytoskeletal remodeling","description":"The cluster centers on receptor-mediated signaling (GPCR and Wnt pathways) with associated cytoskeletal changes (actin filament bundle assembly) and vesicle trafficking regulation (SNARE complex assembly), plus immune and nociception-related processes (pain response, chemokine production, foam cell differentiation). This suggests a cohesive module of signaling proteins that connect transduction, cytoskeletal dynamics, and immune responses.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":7},{"id":"GO:0016055","count":7},{"id":"GO:0048265","count":7},{"id":"GO:2000312","count":6},{"id":"GO:0061408","count":6}]},{"hash":"2025356122195648552","title":"Neuronal development and cytoskeletal signaling","description":"The proteins cluster around terms related to nervous system development, regulation of axonogenesis, and modulation of synaptic plasticity, with accompanying cytoskeletal remodeling (stress fiber assembly) and signaling processes (GPCR desensitization, GTPase activation). While there is some heterogeneity (e.g., hyaluronan metabolism), the dominant theme is neuronal development and related signaling coupled to cytoskeletal dynamics.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050771","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0051496","count":4},{"id":"GO:0043552","count":4}]},{"hash":"604828703190763761","title":"Golgi-ER vesicle trafficking and synaptic vesicle dynamics","description":"This cluster is dominated by GO terms for ER-Golgi vesicle transport, intra-Golgi transport, Golgi ribbon formation, and synaptic vesicle docking/potentiation, plus autophagosome maturation. The common theme is vesicle trafficking through the Golgi-ER system and synaptic vesicle dynamics, suggesting a function in Golgi-ER transport and synaptic vesicle regulation.","confidence":"Medium","size":27,"edges":18,"triangles":3,"max_degree":9,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006888","count":6},{"id":"GO:0048280","count":6},{"id":"GO:0060291","count":6},{"id":"GO:0097352","count":5},{"id":"GO:0006891","count":5}]},{"hash":"1183148979265517082","title":"Developmental Growth and Transcription Regulation","description":"This cluster centers on development (spinal cord development, heart development, post-embryonic development, multicellular organism growth) and transcriptional regulation (negative regulation of transcription by RNA polymerase II, DNA-templated transcription). While some terms are broader physiological processes, the dominant theme links developmental progression with transcription control.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0007596","count":5},{"id":"GO:0021510","count":4},{"id":"GO:0035264","count":4},{"id":"GO:0097011","count":4}]},{"hash":"2019888969888481334","title":"Neural signaling and energy metabolism","description":"This cluster shows enrichment in GPCR signaling and Rho pathways, membrane potential regulation, pain and fear responses, and metabolic processes like electron transport chain activity and diet-induced thermogenesis. Taken together, the proteins appear to link neuronal signaling with cellular energy production and thermoregulation, rather than a single narrow pathway. The varied but connected terms support labeling as neural signaling tied to energy metabolism.","confidence":"Medium","size":27,"edges":2,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":11},{"id":"GO:0022900","count":11},{"id":"GO:0010579","count":11},{"id":"GO:0071502","count":10},{"id":"GO:0002024","count":10}]},{"hash":"2203647116435796577","title":"Ribosome Biogenesis and Translation","description":"The cluster is dominated by GO terms for ribosome biogenesis, transcription by RNA polymerase I, cytoplasmic translation, ribosomal subunit export, and tRNA modification, with translation and ER\u2013Golgi vesicle transport also represented. This points to a cohesive group of proteins involved in ribosome assembly and protein synthesis, with some connection to cell cycle coordination due to growth-related processes.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":8},{"id":"GO:0051301","count":7},{"id":"GO:0007049","count":7},{"id":"GO:0006360","count":6},{"id":"GO:0002181","count":6}]},{"hash":"839501872602719097","title":"Vascular inflammation and coagulation","description":"The cluster shows strong enrichment for blood coagulation, vasoconstriction, and inflammatory signaling (GO:0007596, GO:0045907, GO:0045986, GO:0045907). The inclusion of response to lipopolysaccharide and inflammatory response reinforces a vascular-immune activation theme. A few terms like neuronal stem cell maintenance and brown fat differentiation seem less central and may reflect pleiotropy, but the dominant signals point to a vascular inflammatory/coagulation module.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":11},{"id":"GO:0045907","count":10},{"id":"GO:0032496","count":10},{"id":"GO:0006954","count":10},{"id":"GO:0045986","count":10}]},{"hash":"899581424921519521","title":"Embryonic Organogenesis","description":"The proteins cluster around developmental processes across multiple organs, including hair follicle morphogenesis, kidney development (metanephros and ureteric branching), thymus development, and odontogenesis, with associated vascular remodeling. This shared theme points to roles in organ formation and tissue morphogenesis rather than a single molecular function.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":3},{"id":"GO:0034599","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0001974","count":2},{"id":"GO:0031069","count":2}]},{"hash":"795039026581116931","title":"Transmembrane Transporters","description":"The GO terms are dominated by transmembrane transport processes for various substrates, including nitrates, multiple ions (sodium, potassium, phosphate), sugars, vitamins, and related metabolites. This pattern points to a cluster of membrane transporter proteins focused on uptake and ion/nutrient translocation rather than catalytic metabolism, justifying a label centered on membrane transporters.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042128","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0006004","count":3},{"id":"GO:0015706","count":3}]},{"hash":"334998099852412320","title":"Unknown","description":"The top GO terms cover muscle differentiation/fiber development, B cell signaling, ubiquitin-dependent proteolysis, neural processes (synaptic vesicle endocytosis and memory), angiogenesis, DNA repair, and apoptotic regulation, indicating a highly heterogeneous set without a single cohesive functional theme. This makes it unclear how the proteins function as a single cluster.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0048741","count":3},{"id":"GO:1900242","count":3}]},{"hash":"512659714764685558","title":"Neural development and synaptic signaling","description":"These proteins are dominated by neuronal-related terms: neuron development, positive regulation of glutamatergic synaptic transmission, positive regulation of excitatory postsynaptic potential, and AMPA receptor activity, alongside integrin-mediated signaling and cell adhesion, which together point to roles in neural development and synaptic function. The presence of engulfment of apoptotic cells and adaptive immune response hints at neuron-immune interactions (e.g., microglial activity), but the core clustering centers on neural signaling and development. An outlier term about molting cycle/cuticle appears incidental rather than central to the cluster\u2019s main theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043652","count":4},{"id":"GO:0048008","count":4},{"id":"GO:0051968","count":4},{"id":"GO:0018996","count":3},{"id":"GO:0007155","count":3}]},{"hash":"1454616877013492910","title":"Coenzyme vitamin biosynthesis and energy metabolism","description":"The cluster features multiple biosynthetic and metabolic terms centered on vitamins and core metabolism, including phylloquinone and menaquinone biosynthesis, pyruvate and fatty acid oxidation processes, and several catabolic pathways. Notch signaling appears only sparsely, suggesting it is an outlier rather than a defining theme. Overall, the proteins seem linked to cofactor/vitamin biosynthesis and energy metabolism rather than a single specific pathway.","confidence":"Medium","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":8},{"id":"GO:0033512","count":7},{"id":"GO:0019878","count":7},{"id":"GO:0042866","count":6},{"id":"GO:0042372","count":6}]},{"hash":"2289032389948885367","title":"Eukaryotic translation initiation and RNA processing","description":"The cluster is dominated by GO terms related to translation initiation and preinitiation complex formation, including IRES-dependent initiation and termination-reinitiation, plus regulation of mRNA export, stability, and splicing. This points to a cohesive theme around translating mRNA and its post-transcriptional processing, with involvement in initiation factor assembly (eIF4F complex) and RNA processing steps. ","confidence":"High","size":26,"edges":15,"triangles":9,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":11},{"id":"GO:0001731","count":11},{"id":"GO:0006446","count":9},{"id":"GO:0075522","count":9},{"id":"GO:0075525","count":9}]},{"hash":"849423133514910251","title":"Developmental signaling and neurogenesis","description":"This cluster is characterized by enrichment of developmental signaling pathways (ROBO Roundabout and SHH Smoothened) alongside nervous system development and neurogenesis, with additional organogenesis terms (kidney and vagina development) and cell proliferation. The dominant theme appears to be signaling-driven neurodevelopment and broader tissue development, suggesting these proteins coordinate growth and patterning via conserved signaling cues.","confidence":"High","size":26,"edges":272,"triangles":1516,"max_degree":25,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035385","count":5},{"id":"GO:0007224","count":5},{"id":"GO:0001822","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0050852","count":5}]},{"hash":"60498263878786597","title":"Vascular-immune regulation","description":"The top GO terms center on coagulation, complement activation, angiogenesis, and leukocyte adhesion/rolling, plus blood pressure regulation, indicating a shared theme of vascular functioning and immune modulation. Outlier terms like dendrite regeneration and amelogenesis exist but do not override the dominant vascular/immune pattern.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007596","count":8},{"id":"GO:0000122","count":8},{"id":"GO:0045766","count":7},{"id":"GO:0006958","count":6},{"id":"GO:0003050","count":6}]},{"hash":"956106089288073572","title":"Neural Development and Immune Signaling","description":"The cluster is enriched with neural development and signaling terms (in utero development, oligodendrocyte differentiation, Wnt signaling, calcium release, angiogenesis) along with immune activation terms (complement pathways and MAC). This suggests proteins involved in developmental CNS signaling with some immune modulation, rather than a single, pure function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051209","count":4},{"id":"GO:0001701","count":4},{"id":"GO:0048709","count":4},{"id":"GO:0006957","count":3},{"id":"GO:2000312","count":3}]},{"hash":"1217314835488098490","title":"Cardiovascular and Immune Signaling","description":"The top GO terms cluster around regulation of cardiovascular functions (blood pressure, coagulation) and immune cell guidance (macrophage chemotaxis), alongside signaling pathways (GPCR) and sensory/metabolic processes (pain, temperature response, membrane potential, thermogenesis). While electron transport chain terms hint at energy provision for signaling, the dominant theme is broad physiological signaling coordinating cardiovascular and immune responses with metabolic context. Cardio-immune signaling best fits these functions, but some terms are peripheral, giving a moderate level of confidence.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":9},{"id":"GO:0022900","count":9},{"id":"GO:0010579","count":9},{"id":"GO:0019233","count":9},{"id":"GO:0071502","count":8}]},{"hash":"1694839991728003723","title":"Developmental and endocrine signaling","description":"Top GO terms center on multicellular development (including eye and ovarian follicle development) with accompanying hormone and stimulus responses, suggesting proteins involved in development modulated by endocrine signals rather than a single pathway. Confidence comes from the mix of development-related terms and hormone response terms, though the cluster is not tightly connected by one specific function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0043010","count":2},{"id":"GO:0045471","count":2},{"id":"GO:1990637","count":2},{"id":"GO:0033087","count":2}]},{"hash":"1522922535542683335","title":"Skeletal System and Skin Development","description":"This cluster centers on developmental processes affecting skeletal tissues (osteoblast differentiation, skeletal system development) and integumentary structures (skin development), with contributions from spinal cord development. The presence of transcriptional and mRNA processing terms suggests gene-expression regulation during differentiation, while signaling-related terms (GTPase activity regulation, VEGF pathway modulation) indicate coordinated signaling controls. Together these terms reflect a coherent developmental program spanning bone, skin, and neural-associated tissues, justifying the label.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001649","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0021510","count":3}]},{"hash":"1753183870619746190","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042759","count":2},{"id":"GO:0006362","count":1},{"id":"GO:0001015","count":1},{"id":"GO:2001209","count":1},{"id":"GO:0051569","count":1}]},{"hash":"1844942684311351406","title":"Unknown","description":"The top terms cover mechanical stress response, DNA replication/transcription, immune signaling, glucocorticoid response, skin proliferation, apoptosis, cardiac cell communication, and cell-cycle regulation, indicating a highly diverse set with no single cohesive theme. ","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071260","count":5},{"id":"GO:0006260","count":3},{"id":"GO:0016064","count":3},{"id":"GO:0031663","count":3},{"id":"GO:0006351","count":2}]},{"hash":"1479806778877356921","title":"B cell Activation and NF-kB Signaling","description":"The top GO terms cluster around adaptive immunity and B cell biology: germinal center formation, B cell receptor signaling, immunoglobulin production, spleen development, and both canonical and non-canonical NF-kappaB pathways, with some associated miRNA transcription regulation. The unusual terms (spermatid development, salivary gland boundary) appear as minor noise relative to the predominant B cell\u2013NF-kB theme.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002467","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0007286","count":2},{"id":"GO:0007249","count":2}]},{"hash":"1901304522120599477","title":"Cell cycle and DNA replication","description":"Although several terms touch on neural or immune contexts, the dominant pattern is cell cycle progression (G1/S transition, meiotic cycle) and DNA replication, with kinetochore localization and hippo signaling fitting into growth and division control; hydrogen peroxide responses reflect general stress checkpoints.","confidence":"Medium","size":25,"edges":16,"triangles":1,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034501","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0051321","count":4},{"id":"GO:0042220","count":4},{"id":"GO:0000082","count":4}]},{"hash":"339511376077319293","title":"Neural development and synaptic transmission","description":"The cluster is dominated by GO terms tied to nervous system development, myelination, neurogenesis, and axon paranode localization, plus synaptic vesicle maturation and neurotransmitter secretion. This combination points to proteins involved in neuron formation and maturation as well as synaptic vesicle trafficking and release, making the neural development/synaptic function theme the most representative.","confidence":"High","size":25,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0042552","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0002175","count":3},{"id":"GO:0022008","count":3}]},{"hash":"1097267874335889414","title":"RNA processing and cell cycle regulation","description":"These GO terms cluster around RNA maturation and transport (RNA guanine-N7 methylation, mRNA transport) and core cell cycle processes (cell division), with related signaling and protein-control activities (TORC1 signaling, GTPase regulation, serine dephosphorylation, and SCF\u2013ubiquitin\u2013proteasome\u2013dependent turnover). The combination suggests a role in coordinating RNA processing with cell-cycle progression and proteostasis.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0036265","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0043547","count":5},{"id":"GO:0051028","count":5},{"id":"GO:0071276","count":5}]},{"hash":"1783552564317888114","title":"Stress-Responsive RNA Processing","description":"The cluster is enriched for RNA-centric functions: regulation of mRNA stability in response to stress, mRNA stabilization, and negative regulation of mRNA splicing via spliceosome, plus regulatory ncRNA-mediated gene silencing. These point to coordinated post-transcriptional control of gene expression under stress, with additional hints from protein folding and xenobiotic response that fit a broader stress-adaptation program. While some terms (e.g., placenta development, mismatch repair) are tangential, the dominant theme centers on RNA processing and stability in stress contexts.","confidence":"Medium","size":25,"edges":219,"triangles":932,"max_degree":23,"top_function":"protein folding","top_go_terms":[{"id":"GO:0010610","count":4},{"id":"GO:0001890","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0043524","count":3},{"id":"GO:0006298","count":3}]},{"hash":"1996299253696275777","title":"Developmental morphogenesis and signaling","description":"The top GO terms cluster around tissue development and remodeling: palatal shelf morphogenesis, prostate gland epithelium morphogenesis, negative regulation of Notch signaling (a key developmental pathway), and smooth muscle migration and cell-matrix adhesion\u2014all indicative of morphogenesis and tissue remodeling. Additional terms like glutamatergic synaptic transmission regulation hint at neural development, while response to lipopolysaccharide and redox-related terms may reflect signaling cross-talk or stress responses that can accompany development. Taken together, these terms point to a theme of development-driven tissue formation and organization.","confidence":"Medium","size":25,"edges":92,"triangles":41,"max_degree":11,"top_function":"wound healing","top_go_terms":[{"id":"GO:0055114","count":15},{"id":"GO:0045746","count":11},{"id":"GO:0032496","count":8},{"id":"GO:0007161","count":8},{"id":"GO:1990134","count":8}]},{"hash":"629312909185078538","title":"RTK signaling in neural development","description":"This cluster centers on receptor tyrosine kinase activation (including PDGF receptor signaling) and downstream PKC-related pathways, coupled with neural development and synaptic maturation terms (Purkinje cell development, synapse maturation, glutamatergic transmission). Together these point to a set of proteins involved in growth-factor\u2013driven signaling that shapes neural development and synaptic function, with a few immune-related terms that may reflect annotation noise. ","confidence":"Medium","size":25,"edges":3,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":19},{"id":"GO:0007171","count":12},{"id":"GO:0048008","count":10},{"id":"GO:0021680","count":9},{"id":"GO:0007338","count":9}]},{"hash":"1076807473210009459","title":"Vascular remodeling and immune signaling","description":"The top GO terms point to angiogenesis, endothelial cell migration, collagen fibril organization, and vasoconstriction, indicating vascular remodeling. Concurrently, complement activation and adaptive immune response show an immune component. ERK cascade regulation and exocytosis/protein secretion suggest signaling and secretory roles, consistent with cross-talk between vascular development and immune processes.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001867","count":7},{"id":"GO:0070374","count":7},{"id":"GO:0030199","count":6},{"id":"GO:0001525","count":6},{"id":"GO:0043536","count":6}]},{"hash":"1946193797712704022","title":"Nuclear transport and mitosis regulators","description":"This cluster is dominated by GO terms for nuclear import/export (NLS-bearing import, ribosomal protein import, mRNA export, nuclear pore assembly) and mitotic chromosome processes (metaphase alignment, sister chromatid separation), with supporting references to GTPase regulation and desumoylation. Together these terms point to proteins involved in nuclear trafficking and chromosome segregation during cell division; a few related trafficking terms (e.g., intrafiliary transport) may reflect broader transport roles.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006607","count":4},{"id":"GO:0060188","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0051292","count":4},{"id":"GO:0051306","count":4}]},{"hash":"1054071703204191320","title":"Angiogenesis and vascular remodeling","description":"Top GO terms emphasize angiogenesis and endothelial processes, along with extracellular matrix remodeling and fibrinolysis (collagen fibril organization, plasminogen activation, Tie signaling). This suggests a cohesive cluster of proteins involved in blood vessel formation, endothelial cell regulation, and ECM/coagulation dynamics, hence the label \"Angiogenesis and vascular remodeling\".","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":12},{"id":"GO:0001525","count":11},{"id":"GO:0090331","count":11},{"id":"GO:2000352","count":11},{"id":"GO:0042730","count":11}]},{"hash":"1487029711459690635","title":"Ubiquitin-Proteasome Regulation of Circadian and Immune Signaling","description":"These proteins are strongly linked to ubiquitin-dependent proteolysis (ubiquitination, SCF-mediated proteasomal degradation, ERAD) and ubiquitin-related regulation, with additional signals for circadian rhythm control and innate immune signaling (innate immune response, B cell receptor signaling). The overlap indicates a module of ubiquitin-driven protein turnover that modulates circadian processes and immune pathways, potentially reflecting stress-linked regulation (cadmium response, JNK signaling).","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0042752","count":7},{"id":"GO:0030433","count":6},{"id":"GO:0031146","count":6},{"id":"GO:0045087","count":6}]},{"hash":"957971174307873826","title":"Hormone-responsive redox signaling","description":"The terms show responses to hormones (estradiol, follicle-stimulating hormone) together with nitric oxide biosynthesis and cellular oxidant detoxification, pointing to a theme of hormone-driven signaling intertwined with redox regulation. A few terms related to cell-matrix adhesion and miscellaneous metabolic processes appear less connected, but the dominant pattern is hormone-triggered signaling modulated by redox state. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0043154","count":5},{"id":"GO:0098869","count":5},{"id":"GO:0007160","count":5},{"id":"GO:0045429","count":4}]},{"hash":"1881738690969868035","title":"Innate Immune Signaling and Cytoskeletal Regulation","description":"The Top Terms show strong signals for innate immune activity (innate immune response, defense response to virus) alongside terms tied to cytoskeletal dynamics and signaling regulation (microtubule-based movement, regulation of microtubule depolymerization, regulation of GTPase activity, Rho signaling). This suggests a theme where immune signaling intersects with cytoskeletal remodeling, even though some terms reflect broader signaling pathways.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0007026","count":2},{"id":"GO:0007182","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0051607","count":2}]},{"hash":"625050134460912079","title":"Unknown","description":"The terms span plant hormone signaling (cytokinin-activated pathway), plant defense (defense response to virus, response to fungicide) and animal neural processes (sensory perception of sound, startle response, excitatory postsynaptic potential, long-term potentiation) plus ion transport, with no single unifying function and no edges connecting proteins, suggesting this cluster is a mixed, non-cohesive set rather than a cohesive biological module.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":3},{"id":"GO:0009736","count":2},{"id":"GO:0030850","count":2},{"id":"GO:0060992","count":2},{"id":"GO:0007605","count":2}]},{"hash":"2046192745936953344","title":"Musculoskeletal and cardiovascular morphogenesis","description":"Top GO terms point to myotube differentiation, skeletal morphogenesis, vasculogenesis, heart left/right asymmetry, motor neuron axon fasciculation, and Notch signaling regulation, with supporting calcium transport and GTPase activity. This combination indicates a developmental module underlying formation and patterning of muscle, bone, heart/vasculature, and neural connections, making the label a concise fit for the cluster.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010831","count":2},{"id":"GO:0045746","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0048705","count":2},{"id":"GO:0097156","count":2}]},{"hash":"107254154913971","title":"Mitochondrial energy production and stress response","description":"The prominent GO terms point to mitochondrial processes: electron transport chain, cristae formation, inner membrane protein insertion, and membrane assembly; plus oxidative stress response and protein maintenance. A few terms referencing apoptosis and DNA damage align with mitochondria-associated cell fate decisions. Together they suggest a cohesive theme around mitochondrial respiration, membrane organization, and stress resilience.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022900","count":1},{"id":"GO:0070301","count":1},{"id":"GO:0006464","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0030091","count":1}]},{"hash":"1106260758027462646","title":"Neuroimmune regulation","description":"The terms span neural-associated processes (grooming behavior, prepulse inhibition) and immune modulation (IL-10 production, TNF regulation, dendritic cell differentiation), with brain-specific pathways like the renin-angiotensin system and ERK signaling. This pattern suggests the cluster reflects neuroimmune signaling and regulation rather than a single pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0007625","count":4},{"id":"GO:0032720","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0051482","count":3}]},{"hash":"763550526741352149","title":"Embryonic morphogenesis and collagen ECM formation","description":"The top GO terms cluster around embryonic development and extracellular matrix (ECM) remodeling, including placenta differentiation, cartilage morphogenesis, left-right patterning, epithelial-to-mesenchymal transition, and collagen biosynthesis/organization. This suggests a cohesive theme of tissue formation and ECM-driven morphogenesis during development, even though several related processes are represented. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060707","count":5},{"id":"GO:0030199","count":4},{"id":"GO:0003323","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0060806","count":4}]},{"hash":"926972081673504236","title":"Melanosome trafficking and pigment development","description":"GO terms cluster around melanosome organization/transport, developmental pigmentation, and related endosomal trafficking and secretory pathways, suggesting a lysosome-related organelle program focused on pigment-bearing organelles. Some terms are peripheral, but the dominant signal supports pigment-related vesicle trafficking.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048066","count":1},{"id":"GO:0048490","count":1},{"id":"GO:0033299","count":1},{"id":"GO:0032816","count":1},{"id":"GO:0060155","count":1}]},{"hash":"918191398067884788","title":"Neural cell adhesion and Rho-GTPase signaling","description":"The top GO terms center on cell adhesion and tight junction-related processes, alongside regulation of Rho/GTPase signaling and integrin pathways, with contextual hints to neural localization and behavior (myelin sheath, social/vocalization behavior, ethanol response). This points to a cohesive theme of neuronal cell adhesion coupled with Rho-GTPase\u2013mediated signaling in neural connectivity and behavior.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070830","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0007229","count":2}]},{"hash":"521909900090144085","title":"Mitotic cell cycle and spindle assembly","description":"The top GO terms show strong enrichment for mitosis-related processes (mitotic cell cycle, mitotic spindle assembly, regulation of G0 to G1). While other terms touch transcription, development, and stress responses, the dominant signal points to cell division machinery, suggesting the proteins largely participate in mitotic progression and spindle dynamics, with possible ancillary roles in gene expression and development.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0090307","count":4},{"id":"GO:0071456","count":3},{"id":"GO:0043588","count":3}]},{"hash":"1429018207348237246","title":"Developmental signaling and cellular dynamics","description":"The top GO terms point to processes across development and signaling, including neural development (axonal fasciculation, regulation of synaptic plasticity), reproduction (single fertilization), and general signaling control (GTPase activity regulation, kinase activity, autophosphorylation). Additional terms span molting, hypoxia response, mRNA transport, and cell cycle, indicating a broad regulatory repertoire rather than a single, cohesive pathway. The most plausible theme is regulation of signaling events during development and morphogenesis, hence this label.","confidence":"Low","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007338","count":12},{"id":"GO:0048168","count":9},{"id":"GO:0007413","count":9},{"id":"GO:0018996","count":8},{"id":"GO:0071456","count":7}]},{"hash":"128428934646526387","title":"Vertebrate neural and skeletal development","description":"This cluster is dominated by terms related to development, especially skeletal system development, forebrain development, neural tube closure, and general multicellular organism development. These indicate a coherent theme around vertebrate neural and skeletal patterning. The presence of more general terms like DNA-templated transcription and the mitotic cell cycle suggests core cellular machinery included in such developmental sets, while a few peripheral terms (defense response to Gram-positive bacterium, cadmium response) are likely ancillary or context-specific. Overall, the predominant signal supports a developmental/neural-skeletal theme.","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001501","count":9},{"id":"GO:0050830","count":8},{"id":"GO:0007275","count":8},{"id":"GO:0030900","count":8},{"id":"GO:0006351","count":7}]},{"hash":"1099448046451573184","title":"Apoptosis and Innate Immunity Regulation","description":"The top GO terms center on programmed cell death (apoptosis, pyroptosis) and the regulation of these processes via ubiquitination, all within the context of innate immune responses. Additional terms point to inflammatory signaling and leukocyte or tissue cell interactions (adherence, extravasation), suggesting a cluster of proteins involved in apoptosis/modulated cell death linked to immune activation and cell migration. While a spindle assembly term appears, the dominant theme is cell-death regulation intertwined with innate immune pathways.","confidence":"Medium","size":24,"edges":6,"triangles":0,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:1990001","count":9},{"id":"GO:0016567","count":9},{"id":"GO:0006915","count":9},{"id":"GO:0070269","count":9},{"id":"GO:0090307","count":9}]},{"hash":"1903286848193345664","title":"Macrophage inflammatory signaling and chemokine production","description":"Although there are no reported edges among the proteins, the enriched GO terms cluster around macrophage biology and inflammatory signaling\u2014chemokine and MIP-1\u03b1 production, regulation of foam cell differentiation, and myeloid apoptotic processes\u2014coupled with related signaling pathways (Wnt, PKC-activating GPCR). Additional terms on actin organization and mRNA processing suggest broader cellular machinery, but the dominant theme points to macrophage-driven inflammatory signaling and chemokine production. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0016055","count":4},{"id":"GO:0061408","count":4},{"id":"GO:0010745","count":4},{"id":"GO:0051017","count":4}]},{"hash":"1215750689370575414","title":"Unknown","description":"The GO terms cover diverse processes (actin crosslinking, terminal web assembly, chromatin localization, fungal ascospore formation, karyogamy) plus development and sensory/heart morphogenesis and hypoxia response. There is no clear shared function linking all items, so a cohesive label isn\u2019t supported.","confidence":"","size":24,"edges":24,"triangles":1,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":4},{"id":"GO:0030437","count":4},{"id":"GO:1902896","count":4},{"id":"GO:0051764","count":4},{"id":"GO:0000742","count":4}]},{"hash":"1691045811143598993","title":"Integrin-mediated ECM adhesion and remodeling","description":"The terms cluster around extracellular matrix interactions and turnover: integrin signaling, cell-matrix adhesion, hyaluronan metabolism, metallopeptidase activity, and regulation of ECM assembly, plus substrate-dependent migration. This points to a coherent function in how cells adhere to and remodel the ECM, with dendrite regeneration likely reflecting ECM roles in neural remodeling; overall, the dominant theme is ECM adhesion and remodeling.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070208","count":10},{"id":"GO:0007229","count":9},{"id":"GO:0030212","count":8},{"id":"GO:0007161","count":8},{"id":"GO:0007596","count":8}]},{"hash":"1435907019802068976","title":"ER-Golgi trafficking and secretory pathway","description":"The cluster is dominated by GO terms related to the secretory pathway, including ER-to-Golgi vesicle transport, COPI-coated vesicle budding, and Golgi ribbon formation, plus protein retention in the ER lumen. Wnt protein secretion regulation ties into this trafficking network, suggesting these proteins coordinate intracellular transport and secretion. While some terms touch on developmental or behavioral processes, they likely reflect downstream effects of secreted signals rather than alternative, unrelated functions. Overall, the core theme is ER-Golgi\u2013mediated protein trafficking.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0090161","count":4},{"id":"GO:0061357","count":3},{"id":"GO:0048042","count":3},{"id":"GO:0007311","count":3}]},{"hash":"1559173365307753025","title":"Immune activation and cell adhesion","description":"This cluster shows strong signals for immune processes (complement activation via classical and lectin pathways; T cell costimulation) together with cell adhesion (cell-matrix and heterophilic cell-cell adhesion) and proteolysis, implying a theme of immune surveillance linked to extracellular matrix interactions and remodeling. A few terms (symbiont entry, locomotory behavior) are peripheral rather than central to this core theme.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007160","count":6},{"id":"GO:0031295","count":4},{"id":"GO:0060244","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0001867","count":4}]},{"hash":"2023519470299105605","title":"RNA synthesis and translation core machinery","description":"The dominant terms are translation, DNA-templated transcription, and rRNA maturation with related transcription termination, pointing to proteins involved in RNA synthesis and ribosome biogenesis. Additional signals like phosphorylation, insulin response, and biotin biosynthesis suggest broader regulatory context, but the core cluster appears tied to transcription/translation machinery and RNA processing rather than a single signaling pathway. ","confidence":"High","size":24,"edges":47,"triangles":79,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0006351","count":4},{"id":"GO:0000462","count":3},{"id":"GO:0032869","count":2},{"id":"GO:0044209","count":2}]},{"hash":"882848728955030543","title":"Ubiquitin-Dependent Protein Degradation","description":"The top terms center on ubiquitin-dependent protein catabolic processes and K33-linked ubiquitination, suggesting that regulated protein turnover is the core function of this cluster; while there are some immune and muscle development terms, they appear less consistently tied to the main theme.","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":6},{"id":"GO:2000312","count":5},{"id":"GO:0042787","count":5},{"id":"GO:0002467","count":4},{"id":"GO:0050853","count":4}]},{"hash":"1027559240906282951","title":"Multi-Tissue Development","description":"This cluster is driven by GO terms pointing to development across several tissues (bone development, roof of mouth development, osteoblast fate, endocardial cushion EMT, pancreatic cell development), suggesting a shared theme of developmental differentiation across tissues. The presence of RNA processing terms (mRNA splicing, rRNA modification) likely reflects general gene-expression machinery present in many proteins, rather than a single cohesive pathway, but the strongest signal is developmental across multiple tissues.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0060021","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0000154","count":3}]},{"hash":"1270084306007324982","title":"TLR\u2013NF-\u03baB Innate Immune Signaling with Autophagy","description":"The cluster is dominated by terms involving Toll-like receptor signaling (TLR2/3/9), response to lipopolysaccharide, and NF-\u03baB activation, along with related processes like B cell activation, apoptosis, and macroautophagy. This pattern points to a coherent theme of innate immune sensing and downstream signaling with autophagic and cell fate regulation, rather than unrelated processes.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050871","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0034162","count":2},{"id":"GO:0034138","count":2},{"id":"GO:0034134","count":2}]},{"hash":"296075746976174046","title":"Cardiac and skeletal muscle development and contraction","description":"The dominant GO terms center on muscle biology\u2014heart development, cardiac muscle contraction, skeletal muscle fiber development, and regulation of calcium release\u2014indicating a muscle development/contraction theme. Some terms (visual perception, opsin signaling, vesicle endocytosis) are less connected and may reflect annotation noise or multi-function proteins, but the core signal supports a muscle-focused cluster.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0051384","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0010881","count":2},{"id":"GO:0048741","count":2}]},{"hash":"991978357265854159","title":"Regulation of Signaling and Transcription","description":"This cluster centers on regulatory processes: several terms point to regulation of Rho and Ras signaling and regulation of DNA-templated transcription, alongside related regulatory activities like synaptic vesicle priming and acrosome reaction. The common thread is a broad emphasis on controlling signaling pathways and gene expression, with additional associations to vesicle trafficking events, suggesting a general regulatory role across cell signaling and transcription.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0006351","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0016082","count":3},{"id":"GO:0043314","count":3}]},{"hash":"1461343793424134274","title":"Cross-Tissue Developmental Signaling","description":"This cluster's terms cluster around developmental processes across multiple tissues (renal, olfactory bulb, lens, spermatid) and SMAD/TGF-beta\u2013related signaling, along with associated transcription. A few immune-related terms broaden the signaling context, but the common thread appears to be signaling and transcription governing tissue development across diverse organs rather than a single, specific function.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043001","count":2},{"id":"GO:0072001","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0021772","count":2},{"id":"GO:0060395","count":2}]},{"hash":"408250210898075932","title":"ER-Golgi vesicle trafficking and Golgi organization","description":"Based on the top GO terms, these proteins cluster around ER-to-Golgi vesicle transport, COPII-coated vesicle budding, and Golgi organization, indicating a cohesive module of vesicular trafficking and Golgi maintenance. The presence of growth/division terms likely reflects broader cellular proliferation context, but the dominant signal is ER-Golgi transport.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":5},{"id":"GO:0006890","count":5},{"id":"GO:0008283","count":4},{"id":"GO:0090114","count":4},{"id":"GO:0051301","count":4}]},{"hash":"305914212097870711","title":"Regulation of signaling and protein turnover","description":"The top GO terms cluster around dampening signaling pathways (negative regulation of VEGF receptor signaling, ERK cascade, and IL-6 signaling) and ubiquitin-dependent protein degradation via the multivesicular body pathway, suggesting a core theme of signaling attenuation through turnover. Additional terms touch on transcriptional regulation and RNA export, with a few context-specific developmental processes, which may reflect broader roles or annotations in different organisms. Overall, the common thread is modulation of signaling intensity through ubiquitin-mediated turnover and trafficking, with some ancillary connections to gene expression.","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030948","count":3},{"id":"GO:0043162","count":3},{"id":"GO:0070373","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0045944","count":2}]},{"hash":"312827586777661128","title":"Auditory system development and hearing function","description":"The terms cluster strongly around inner ear and auditory processes: cochlea development, inner ear receptor cell development, sensory perception of sound, and cholinergic synaptic transmission, plus potassium transport tied to neuronal activity. There are also autonomic/motor-related terms (regulation of norepinephrine secretion, heart rate regulation via baroreceptors, and adult walking behavior) that suggest broader neuromodulatory or behavioral links. A couple terms (e.g., chondrocyte intercalation) seem less related and may be noise. Overall, the core signal points to auditory system development and hearing function, with some secondary ties to autonomic regulation and movement. ","confidence":"Medium","size":23,"edges":35,"triangles":16,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0001988","count":6},{"id":"GO:0003428","count":6},{"id":"GO:0090102","count":6},{"id":"GO:0007271","count":6},{"id":"GO:0007605","count":6}]},{"hash":"1332567766541171377","title":"GPCR-Driven Cardiometabolic Signaling","description":"This cluster centers on GPCR-related signaling that activates adenylyl cyclase, tying together cardiovascular regulation (blood pressure) with metabolic processes (electron transport chain and thermogenesis). The presence of Rho signaling and temperature-responsive terms alongside GPCR pathways suggests a shared theme of GPCR-driven cardiometabolic signaling, with broader processes like pain perception and TNF regulation as downstream associations.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":20},{"id":"GO:0022900","count":20},{"id":"GO:0010579","count":20},{"id":"GO:0035025","count":18},{"id":"GO:0071502","count":17}]},{"hash":"1994259990077155390","title":"Diverse Metabolic Biosynthesis and Catabolism","description":"GO terms show a mix of biosynthetic and catabolic processes across vitamins, lipids, nucleotides, and chlorophyll, plus nitrogen utilization. This pattern points to a cluster of proteins involved in broad metabolism rather than a single pathway, with both creation and breakdown activities represented. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009102","count":5},{"id":"GO:0017000","count":5},{"id":"GO:0019433","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0006212","count":5}]},{"hash":"1071929969638191386","title":"Neuronal development and axon guidance","description":"This cluster centers on nervous system development and neuron-associated processes, including neuron apoptotic regulation, filopodium (neurite) assembly, and Roundabout signaling, which points to roles in neural differentiation, neurite outgrowth, and axon guidance. Additional terms span transcription and general growth and signaling, with some broad cellular transport processes, suggesting a neural development module with supporting signaling activities.","confidence":"High","size":23,"edges":12,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0043525","count":5},{"id":"GO:0046847","count":4},{"id":"GO:0006888","count":4}]},{"hash":"285774770114877584","title":"Axon Guidance and Neural Crest Development","description":"The top GO terms cluster around neural development, especially axon extension and guidance (positive regulation of axon extension involved in axon guidance; semaphorin-plexin signaling pathway involved in axon guidance; sympathetic neuron projection guidance/extension; trigeminal nerve structural organization), and neural crest migration (ventral trunk neural crest cell migration). While there are a few terms tied to broader developmental processes like coronary morphogenesis and skeletal muscle development, the shared theme is neural pathfinding and neural crest\u2013driven organization, justifying a label focused on axon guidance and neural crest development.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000312","count":5},{"id":"GO:0060982","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0048842","count":4},{"id":"GO:0048741","count":4}]},{"hash":"1014162654628406587","title":"Arabinogalactan protein metabolism and root hair development","description":"The dominant GO terms point to plant-specific glycoprotein biology, especially arabinogalactan protein metabolic processes and related glycan biosynthesis, coupled with root hair cell development. This suggests the cluster centers on AGP-related cell wall functions in plants, with some outlier terms that are less representative. Therefore this label best captures the core shared function of the cluster.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0006310","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0006284","count":3},{"id":"GO:0030311","count":3}]},{"hash":"827319139075624522","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0006890","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0000472","count":3},{"id":"GO:0042273","count":3}]},{"hash":"1892820429343394619","title":"Unknown","description":"The terms span purine transport (urate, xanthine, adenine), transcription regulation, cell cycle, apoptosis, and nitrogen metabolism, with no single cohesive biological theme linking the proteins. This diversity suggests the cluster does not represent a singular, well-defined function.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0015747","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000278","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0042420","count":2}]},{"hash":"469285111900720345","title":"Innate immune response to lipopolysaccharide","description":"This cluster shows enrichment for GO terms related to LPS recognition and downstream immune signaling, including cellular response to lipopolysaccharide, interferon-beta production, and positive regulation of IL-12 production, suggesting a role in responding to bacterial components. While there are some metabolic and transcription-related terms present, the immune-related terms provide a coherent theme, supporting a moderate level of confidence in this labeling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019284","count":4},{"id":"GO:0019509","count":4},{"id":"GO:0009088","count":4},{"id":"GO:0046677","count":4},{"id":"GO:0016310","count":4}]},{"hash":"997534081000188870","title":"Developmental transcriptional regulation and differentiation","description":"The cluster\u2019s top GO terms cluster around DNA-templated transcription and its regulation, together with multicellular development signals (placenta development, osteoblast differentiation) and associated proliferation (mitotic cell cycle). This points to a coordinated developmental gene-expression program governing differentiation and tissue formation, with a few outlier terms related to stress responses and specific transport activities. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0001890","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0001403","count":3},{"id":"GO:2000811","count":3}]},{"hash":"1980515386311517671","title":"Amino and Fatty Acid Catabolism","description":"Dominant GO terms are amino acid catabolic processes (leucine, valine) and fatty acid catabolism, plus carnitine metabolism and fatty-acyl-CoA biosynthesis, suggesting a cluster centered on energy-yielding metabolic pathways. While there are a few developmental terms, the core theme is amino and fatty acid degradation and related energy mobilization.","confidence":"High","size":23,"edges":8,"triangles":4,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0006552","count":4},{"id":"GO:0051793","count":3},{"id":"GO:0019254","count":3},{"id":"GO:0009791","count":3}]},{"hash":"827843296657899895","title":"Unknown","description":"The top GO terms span skin differentiation, lung development, neuronal structure, bacterial biosynthesis, and general oxidant detoxification, with no single unifying pathway or function. The lack of a coherent theme and no network connectivity suggest no representable cluster-level function can be assigned.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0045987","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0030216","count":3},{"id":"GO:0098869","count":3}]},{"hash":"584403591656566259","title":"Diverse transmembrane transporters","description":"This cluster is characterized by GO terms for transporting various solutes across membranes\u2014glucose, sialic acid, fucose, sodium, potassium, phosphate, and xenobiotics\u2014and includes related osmotic stress response and neurotransmitter loading into vesicles. The shared theme is membrane transport activity across diverse substrates.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":5},{"id":"GO:0006855","count":4},{"id":"GO:0006970","count":4},{"id":"GO:0015739","count":3},{"id":"GO:0006004","count":3}]},{"hash":"863231510830569285","title":"Meiotic nuclear events and transcription","description":"The cluster shows enrichment for nuclear processes tied to meiosis and cell cycle control, including meiotic nuclear division, meiotic cell cycle, DNA-templated transcription, regulation of DNA replication, and kinetochore localization, along with nuclear import and nuclear membrane reassembly, suggesting a cohesive theme of nuclear gene expression and chromosome segregation during meiosis.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:2001241","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0006607","count":2},{"id":"GO:0007084","count":2}]},{"hash":"322837636479920825","title":"Neural development and axon guidance","description":"This cluster is dominated by GO terms related to nervous system development, neuron projection development, axon guidance, and synapse assembly, with additional links to Rho-mediated cytoskeletal signaling, suggesting a cohesive focus on neural connectivity and pathfinding, despite a few terms like sarcomere organization that may reflect shared structural regulation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":5},{"id":"GO:0007399","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0051965","count":3},{"id":"GO:0007413","count":3}]},{"hash":"2143730464387867512","title":"Synaptic Plasticity and Neuroinflammation","description":"The top GO terms point to neuronal signaling and plasticity (long-term synaptic potentiation, regulation of synaptic transmission, presynapse signaling, intracellular transport). There is also a clear signal of inflammatory pathways (nitric oxide production, IL-1\u03b2 production, NLRP3 inflammasome assembly). Together these imply a cluster of proteins involved in synaptic function with associated inflammatory regulation, though some terms appear noisy or less related. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060291","count":2},{"id":"GO:0045429","count":2},{"id":"GO:0050702","count":2},{"id":"GO:1900227","count":2},{"id":"GO:0043001","count":2}]},{"hash":"645518434817551469","title":"Coagulation and Complement Activation with ECM Remodeling","description":"The top GO terms cluster around blood coagulation (blood coagulation, plasminogen activation, fibrinolysis) and complement activation (lectin and classical pathways), with accompanying extracellular matrix remodeling (extracellular matrix disassembly, biomineral tissue development) and defense against Gram-positive bacteria. This points to a coherent theme of hemostasis and innate immune defense coupled with tissue remodeling.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0014068","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0030194","count":6},{"id":"GO:0007596","count":5},{"id":"GO:0006958","count":5}]},{"hash":"885089833481225206","title":"Innate Immunity and Fish Skeletal Development","description":"This cluster shows strong signals for innate immune response and defense to virus, along with otolith morphogenesis and bone development, suggesting a combined theme of immune function and skeletal/calcified structure formation in fish. Supporting terms like actin filament assembly, cell migration, ubiquitination, and calcium release point to cytoskeletal remodeling and signaling linked to these processes. Confidence is Moderate because two related but distinct themes are present.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0071260","count":3},{"id":"GO:0032474","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0051607","count":3}]},{"hash":"633967998061451358","title":"Membrane Transporters and Motility Regulators","description":"Top GO terms indicate multiple transmembrane transport processes (glucose, biotin, myo-inositol, pantothenate, sodium export) and acetylcholine biosynthesis, along with Rho signaling, lamellipodium assembly, and fibroblast migration. This suggests a cluster of proteins involved in membrane transport and in cytoskeletal regulation of cell movement, rather than a single cohesive metabolic pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008292","count":2},{"id":"GO:0015878","count":2},{"id":"GO:1904659","count":2},{"id":"GO:0071436","count":2},{"id":"GO:0015798","count":2}]},{"hash":"956531932155649971","title":"Eye development and photoreceptor maintenance","description":"The top GO terms are centered on eye morphogenesis and photoreceptor maintenance (camera-type eye morphogenesis, photoreceptor cell maintenance) with supporting neural development and synaptic regulation terms (GABAergic transmission, neuron apoptotic regulation). This suggests a coherent theme around visual system development and photoreceptor biology, with related neural signaling and apoptotic processes.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0048593","count":3},{"id":"GO:0045494","count":3},{"id":"GO:0048485","count":2},{"id":"GO:0035021","count":2}]},{"hash":"2107594095647433172","title":"B cell activation and germinal center formation","description":"The cluster is dominated by immune-related terms: B cell receptor signaling pathway and germinal center formation, plus negative regulation of isotype switching to IgE, indicating a focus on B cell activation and maturation. Ubiquitin-dependent proteolysis and regulation of protein ubiquitination suggest modulation of signaling pathways. While a few terms refer to nervous system and muscle development, the strongest and most coherent theme centers on adaptive immune signaling in B cells.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007399","count":11},{"id":"GO:0050853","count":10},{"id":"GO:0002467","count":10},{"id":"GO:0007519","count":10},{"id":"GO:0042787","count":10}]},{"hash":"277979059534066514","title":"Nuclear Transport and Stress Signaling","description":"The cluster centers on nuclear-cytoplasmic trafficking (NLS-bearing protein import into nucleus; mRNA transport) and regulatory signaling linked to GTPase activity, apoptosis, and stress responses (hypoxia, mitochondrial calcium), with additional links to vacuolar fusion and cell-cycle/development terms that may reflect broader cellular context. This suggests a cohesive theme around transport coupled with stress and fate regulation, rather than a single metabolic pathway.","confidence":"Medium","size":22,"edges":5,"triangles":2,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0006607","count":5},{"id":"GO:0051028","count":5},{"id":"GO:0043065","count":5},{"id":"GO:0051561","count":5}]},{"hash":"151354153370657655","title":"Actin dynamics and junction assembly","description":"The top GO terms center on actin cytoskeleton regulation (Rac signaling, Arp2/3\u2013mediated nucleation, lamellipodium assembly, barbed-end capping) and cell\u2013cell junction formation (bicellular tight junction assembly, its positive regulation). Additional terms for dendritic spine morphogenesis and long-term synaptic depression point to actin-driven remodeling in neurons, while megakaryocyte and osteoclast development reflect cytoskeletal dynamics in other cell types. Together, the cluster likely represents proteins coordinating actin remodeling with cell junction assembly and related morphological changes.","confidence":"High","size":22,"edges":110,"triangles":412,"max_degree":16,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070830","count":8},{"id":"GO:0016601","count":8},{"id":"GO:1903348","count":7},{"id":"GO:0051016","count":7},{"id":"GO:0035855","count":7}]},{"hash":"2189419791522064427","title":"Unknown","description":"The top GO terms span innate immunity, plant hormone signaling, development across organs, and general cellular processes with no clear unifying function, making it hard to assign a concise, representative label.","confidence":"","size":22,"edges":14,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0009089","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0009938","count":5},{"id":"GO:0055059","count":4},{"id":"GO:0051301","count":4}]},{"hash":"604155990393414218","title":"GTPase-Driven Cell Migration and Exocytosis","description":"The top GO terms cluster around small GTPase signaling and its role in cytoskeletal dynamics, exocytosis, and cell movement\u2014including regulation of GTPase activity, small GTPase-mediated signaling, podosome/actin structures, epithelial polarity, and macrophage chemotaxis. Additional terms on calcium-dependent exocytosis and hormone secretion support a theme of regulated vesicle trafficking linked to migratory and polarizing cellular processes.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045956","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0071803","count":2}]},{"hash":"1681113169078751417","title":"ECM adhesion and remodeling","description":"Most terms point to extracellular matrix interactions and remodeling: calcium-independent cell-matrix adhesion, heterotypic cell-cell adhesion, substrate-dependent cell migration, hyaluronan metabolism, and metallopeptidase activity, with ubiquitin-dependent protein turnover also tying to remodeling processes. The chlorophyll biosynthetic term appears as an outlier, not driving the core theme. ","confidence":"Medium","size":22,"edges":13,"triangles":0,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007161","count":9},{"id":"GO:0007596","count":9},{"id":"GO:0031104","count":9},{"id":"GO:0030212","count":7},{"id":"GO:1905050","count":7}]},{"hash":"2104316455092822760","title":"Developmental transcription regulation and immune differentiation","description":"The cluster is enriched in transcription by RNA polymerase II (dominant term) and includes multiple developmental processes (placenta development, outflow tract morphogenesis) along with immune differentiation signals (macrophage differentiation, plasma cell differentiation, IL-4 response, and miRNA transcription). This points to a core of transcriptional regulators coordinating developmental programs and immune cell lineages.","confidence":"High","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":15},{"id":"GO:0001892","count":10},{"id":"GO:0035470","count":9},{"id":"GO:0030225","count":9},{"id":"GO:0071353","count":9}]},{"hash":"981936101699491086","title":"Transposons and Proviral Integration","description":"The top GO terms cluster around DNA mobility and viral genome handling: DNA replication, DNA integration, DNA transposition, retrotransposition, and integrated proviral latency, plus related processes like viral entry into the host nucleus. These point to activity of transposable elements and proviral integration rather than a single canonical cellular pathway, with some immune-related terms appearing as broader annotations. Confidence in this cohesive theme is high.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0007519","count":4},{"id":"GO:0075713","count":3}]},{"hash":"650526289935935326","title":"Metanephric nephron development and angiogenesis regulation","description":"Top GO terms indicate coordinated kidney nephron morphogenesis (ascending limb, distal tubule, thick ascending limb) with adhesion and extracellular matrix interactions, plus regulatory signals for angiogenesis and vascular differentiation. This suggests a developmental program linking nephron formation to vascular remodeling rather than a single isolated function.","confidence":"Medium","size":22,"edges":14,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0072218","count":6},{"id":"GO:0007160","count":4},{"id":"GO:0072221","count":4},{"id":"GO:0072233","count":4},{"id":"GO:0007155","count":3}]},{"hash":"337037881327794599","title":"Lipid and pigment metabolism","description":"This cluster centers on lipid remodeling and pigment breakdown (triglyceride and chlorophyll catabolism; phospholipid dephosphorylation; epoxygenase P450), with additional biosynthetic terms suggesting a broader metabolic module rather than a single, narrow function.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":3},{"id":"GO:0009102","count":2},{"id":"GO:0009086","count":2},{"id":"GO:0019740","count":2},{"id":"GO:0015996","count":2}]},{"hash":"216887668354900994","title":"Membrane ion transport and protein trafficking","description":"The cluster is enriched for membrane-related transport terms: sodium ion import and potassium ion export across the plasma membrane, plus general protein transport and cell volume homeostasis, indicatingmembrane transport and trafficking as the core theme. A few outlier terms (temperature response, development) are less central, so the label remains focused on the dominant functions.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0098719","count":2},{"id":"GO:0097623","count":2},{"id":"GO:0015031","count":2},{"id":"GO:0051096","count":2},{"id":"GO:0006884","count":2}]},{"hash":"1624476685120916016","title":"Filopodium formation via Rho GTPase signaling","description":"The top terms center on actin-based protrusions (filopodia) and Rho-family GTPase signaling, including small GTPase-mediated pathways, regulation of Rho signaling, and adhesion-dependent cell spreading, which together define cytoskeletal remodeling and protrusion dynamics. Additional terms about synapse plasticity and tight junctions are related but secondary to the core filopodial/cytoskeletal theme.","confidence":"High","size":22,"edges":29,"triangles":4,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007264","count":12},{"id":"GO:0051489","count":12},{"id":"GO:1900026","count":12},{"id":"GO:0046847","count":11},{"id":"GO:0051835","count":9}]},{"hash":"697987853798503147","title":"Immune signaling with angiogenesis","description":"The top GO terms indicate strong involvement in lymphoid signaling (T and B cell activation, differentiation, beta selection, BCR signaling) as well as endothelial/angiogenic signaling (VEGF receptor pathway, angiogenesis) and apoptotic regulation, suggesting a cluster of proteins coordinating immune activation with vascular growth and related signaling.","confidence":"Medium","size":22,"edges":57,"triangles":49,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048010","count":22},{"id":"GO:0050798","count":22},{"id":"GO:0043366","count":22},{"id":"GO:0043068","count":22},{"id":"GO:0061387","count":22}]},{"hash":"1389488108590207121","title":"Neuronal development and axon guidance","description":"The top GO terms cluster around neural development (nervous system development, dendrite/axon development) and connectivity (axon guidance, synapse structural plasticity, ROBO signaling). A few terms (cochlea morphogenesis, ossification, mast cell chemotaxis) suggest broader roles for some proteins, but the dominant theme is neurodevelopment and neural connectivity.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0007286","count":2},{"id":"GO:0016358","count":2},{"id":"GO:2000785","count":2},{"id":"GO:0051835","count":2}]},{"hash":"1877942938977086417","title":"Neurotransmitter transport and brain development","description":"This cluster is dominated by neurotransmission-related GO terms (glycine, dopamine, serotonin handling) and brain development terms (thalamus, adenohypophysis), indicating a cohesive function in synaptic signaling and brain maturation, with supporting glial involvement.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0015820","count":6},{"id":"GO:0051583","count":6},{"id":"GO:0021984","count":6},{"id":"GO:1905847","count":6},{"id":"GO:0042066","count":6}]},{"hash":"1354515856212234693","title":"Unknown","description":"The top GO terms span diverse biological areas (protein homooligomerization, synapse assembly, hair orientation, Wnt signaling, endothelial chemotaxis, complement activation, fibrinolysis, vocalization). They come from development, nervous system, immunity, and vascular contexts with no single dominant function linking them, so a concise, representative label isn\u2019t apparent.","confidence":"","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0051260","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0048105","count":5},{"id":"GO:0044332","count":5},{"id":"GO:2001027","count":5}]},{"hash":"1200446079632533490","title":"Cytoskeleton remodeling and neuronal signaling","description":"The cluster shows enrichment for actin cytoskeleton processes (actin filament network formation, Rho signaling) and signaling pathways (GABAergic synaptic transmission, thrombin-activated receptor signaling), plus trafficking and organelle dynamics (endocytic recycling, mitochondrial fission). This pattern points to a cohesive theme of cytoskeleton-driven signaling and receptor trafficking in neurons; some terms like bone development or TOR regulation may reflect broader roles of the included proteins rather than the core theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902499","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0070493","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0051639","count":2}]},{"hash":"485348813842776930","title":"Proteostasis and stress signaling","description":"Top terms cluster around protein quality control and stress responses: ubiquitin-dependent ERAD pathway and positive regulation of ubiquitin ligase activity point to ubiquitin-proteasome\u2013mediated turnover; translation preinitiation complex formation links to initiation of protein synthesis; nutrient and hypoxia signaling indicate metabolic adaptation, with SREBP signaling suggesting lipid metabolism adjustment under stress. Although several terms are obsolete, the remaining terms collectively imply a theme of maintaining proteostasis during metabolic and environmental stress. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0046784","count":3},{"id":"GO:1904668","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0032933","count":3}]},{"hash":"477686464358255869","title":"Ribosome Biogenesis and Cell Division","description":"Based on the top terms, the cluster is dominated by ribosome biogenesis, SSU-rRNA maturation, and cell division, with additional phosphorylation, pointing to a role in ribosome assembly and cell proliferation. A few signaling and inflammatory terms appear as minor annotations and do not define the main function of the cluster.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0019284","count":2},{"id":"GO:0019509","count":2},{"id":"GO:0016310","count":2}]},{"hash":"2077870295255938293","title":"Ubiquitin-Proteasome Regulation and Circadian/Development Signals","description":"This cluster centers on ubiquitin-dependent proteolysis and SCF-mediated degradation, implying a core role in targeted protein turnover. The additional terms tie this proteostasis activity to circadian rhythm regulation and development, with links to DNA damage response and stress signaling. The unifying theme is ubiquitin-proteasome\u2013circadian regulation across growth and stress responses.","confidence":"High","size":22,"edges":12,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:0031146","count":12},{"id":"GO:0042752","count":12},{"id":"GO:0031571","count":11},{"id":"GO:1903378","count":11}]},{"hash":"2030324473884345143","title":"Cartilage and bone development","description":"The cluster is dominated by GO terms for ossification (intramembranous and endochondral), cartilage development and condensation, and collagen biosynthesis, pointing to skeletal tissue formation. Some terms like skin development and immune/complement or sodium channel clustering appear as noise but do not override the core cartilage/bone morphogenesis signal.","confidence":"High","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001957","count":2},{"id":"GO:0001958","count":2},{"id":"GO:0060351","count":2},{"id":"GO:0001502","count":2},{"id":"GO:2000584","count":2}]},{"hash":"953274058145457655","title":"Cytoskeletal organization and axonal junctions","description":"The cluster centers on cytoskeletal dynamics (sarcomere organization, actin cytoskeleton regulation, Rho signaling) and specialized cell\u2013cell junction formation in neurons (paranode/juxtaparanode localization and junction assembly). These shared themes suggest a cohesive function in shaping cell morphology and organizing intercellular contacts, even though a few terms reflect broader developmental contexts (lens, angiogenesis, immune signaling). ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045214","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0035023","count":2},{"id":"GO:2000249","count":2},{"id":"GO:0050860","count":2}]},{"hash":"1388300859549507407","title":"MAPK/Rho signaling in cardiovascular development","description":"This cluster is driven by multiple signaling pathways (MAPK/ERK, Rho, PI3K) and cellular responses (mechanotransduction) that are central to cardiovascular development and vascular function. The presence of heart development, blood coagulation, nitric oxide biosynthesis, and collagen-related regulation suggests a cohesive theme of signaling coordinating heart/vascular development and mechano-responsive remodeling, with supporting neural development signals as parallels. Confidence: Medium","confidence":"","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0033138","count":3}]},{"hash":"1087043727468708084","title":"Immune signaling and response pathways","description":"The cluster is enriched for innate and adaptive immune terms (innate and adaptive immune response, B cell receptor signaling, interferon signaling) plus small GTPase\u2013mediated signaling, indicating a cohesive immune signaling module. Oxidation-related terms appear but are secondary to the immune signal terms, supporting a primary interpretation as an immune-related cluster.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0060335","count":2}]},{"hash":"613275652810526000","title":"ERK-regulated angiogenic and inflammatory signaling","description":"This cluster is enriched for GO terms related to ERK signaling, angiogenesis, and inflammatory mediator production (e.g., positive regulation of ERK cascade, leukotriene biosynthesis). The inclusion of secretory granule localization and post-translational control via ubiquitination/deubiquitination suggests coordinated secretory and signaling regulation in angiogenic/inflammatory contexts, making this a coherent functional module.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0032252","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0045765","count":2}]},{"hash":"1439910835088935183","title":"Inflammation and vascular stress response","description":"The proteins in this cluster show enrichment for inflammatory response, cellular response to hypoxia, and regulation of vasoconstriction, along with responses to mechanical stimuli and lipopolysaccharide. This combination points to a cohesive module involved in vascular-immune stress signaling, even though a few terms are obsolete. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045907","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0071456","count":3},{"id":"GO:0031915","count":3},{"id":"GO:0071260","count":3}]},{"hash":"1290450296242173719","title":"GPCR-Driven cAMP/cGMP Signaling","description":"The top terms point to GPCR-mediated signaling pathways, including adenosine and adrenergic receptor signaling, with downstream second messengers like cAMP and cGMP and broader intracellular signal transduction. Environmental sensing terms such as blue light signaling and hypoxia detection suggest these signals feed into transcriptional regulation and cellular responses. Together, they indicate a signaling module centered on GPCR-initiated second-messenger cascades influencing transcriptional control.","confidence":"Medium","size":21,"edges":9,"triangles":0,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0070483","count":6},{"id":"GO:0009785","count":6},{"id":"GO:0006171","count":6},{"id":"GO:0006355","count":6},{"id":"GO:1900194","count":6}]},{"hash":"1789346696043777753","title":"Ubiquitin-Regulated Signaling and Development","description":"The top GO terms combine immune signaling (B cell receptor signaling, germinal center formation), tissue development (skeletal muscle, distal tubule morphogenesis), and kidney function with recurring ubiquitination themes (negative regulation of ubiquitination, ubiquitin-dependent proteolysis, K33-linked ubiquitination), suggesting a label focused on ubiquitin-mediated regulation of signaling and developmental processes across tissues.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":6},{"id":"GO:0031397","count":6},{"id":"GO:0007519","count":6},{"id":"GO:0070294","count":6},{"id":"GO:2000312","count":6}]},{"hash":"1786565966577116158","title":"Lectin-pathway complement activation and leukocyte recruitment","description":"The top GO terms center on innate immunity and leukocyte interactions: complement activation via the lectin pathway, stimulatory C-type lectin receptor signaling, leukocyte tethering/rolling and adhesion molecule production, basophil activation, and NK cell chemotaxis regulation. A fungal-origin response term supports pattern-recognition activity. While a couple terms hint at development (cartilage condensation, lymph vessel morphogenesis), the immune/lectin- and leukocyte-focused terms dominate, suggesting this cluster represents lectin-mediated innate immune activation and leukocyte recruitment.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0001502","count":7},{"id":"GO:2000502","count":7},{"id":"GO:0071226","count":7},{"id":"GO:0045575","count":7}]},{"hash":"2287926114471414583","title":"Embryonic development and organ morphogenesis","description":"The dominant GO terms describe various stages and processes of embryogenesis and organ morphogenesis (midbrain, pituitary, cartilage, cranial skeleton, palate, heart outflow tract, uterus). This points to proteins involved in developmental regulation and morphogenesis, likely including transcriptional regulators given the negative regulation of transcription by RNA polymerase II. The lipopolysaccharide response term is a minor outlier but does not override the overall developmental theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0030901","count":7},{"id":"GO:0032496","count":5},{"id":"GO:0021983","count":5},{"id":"GO:0051216","count":5}]},{"hash":"1682805785600466383","title":"Core translation and DNA replication factors","description":"This cluster shows strong representation of translation-related terms (cytoplasmic translation, translation) alongside DNA replication and cell cycle processes (DNA replication, DNA biosynthetic process, cell division, cell cycle), suggesting a group of proteins involved in essential growth and proliferation activities, including ribosomal/translation components and replication/cell-cycle factors. The presence of ERAD-related terms and inclusion body regulation hints at quality-control roles, but the dominant theme remains core protein synthesis and genome duplication machinery.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031204","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0030433","count":2},{"id":"GO:1903833","count":2},{"id":"GO:0002181","count":2}]},{"hash":"807200145718786657","title":"B and T cell receptor signaling with PI3K/AKT","description":"Proteins here show clear enrichment for innate immune response and both B cell and T cell receptor signaling, complemented by the positive regulation of PI3K/AKT signaling. This pattern suggests a cluster centered on adaptive immune activation and downstream PI3K pathway signaling triggered by antigen receptors. Some other terms (ribosome biogenesis, embryonic development) appear but are likely incidental to the main immune signaling theme.","confidence":"High","size":21,"edges":56,"triangles":99,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0050853","count":5},{"id":"GO:0051897","count":5},{"id":"GO:0050852","count":5},{"id":"GO:0010863","count":5}]},{"hash":"1584536128178832233","title":"Vascular inflammatory signaling and metabolic responses","description":"The top GO terms point to inflammatory response, VEGF stimulus response, and regulation of blood pressure, plus responses to fatty acids and food, which together suggest endothelial/vascular signaling and metabolic stress responses. Receptor recycling indicates regulation of cell-surface signaling, complementing the vascular/inflammatory theme. A few terms about mitochondrial and chloroplast protein import appear less connected to the core theme, but the dominant function cluster centers on vascular signaling and metabolic responsiveness.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":2},{"id":"GO:0001921","count":2},{"id":"GO:0008217","count":2},{"id":"GO:0035924","count":2},{"id":"GO:0006954","count":2}]},{"hash":"1747404729408887182","title":"Reproductive Development and Prostaglandin Biosynthesis","description":"I chose this label because the strongest GO terms center on prostaglandin biosynthesis and reproductive organ development (uterus, female gonad). Several terms point to broader developmental processes (digestive tract development) and hormonal/retinoid/vitamin D responses, suggesting a cluster tied to developmental biology with prostaglandin signaling as a key motif.","confidence":"Medium","size":21,"edges":36,"triangles":11,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":14},{"id":"GO:0060065","count":14},{"id":"GO:0008585","count":14},{"id":"GO:0048565","count":14},{"id":"GO:0034653","count":13}]},{"hash":"698620532843009881","title":"Embryonic organogenesis and transcription regulation","description":"The cluster\u2019s terms center on embryonic development across multiple organs (eye, brain subregions, placenta, pituitary, pancreas, cranial skeleton) and include transcription by RNA polymerase II with negative regulation, suggesting a coordinated gene-regulatory program during organ formation. Notably, eye morphogenesis terms anchor the theme in early developmental processes, with additional organ morphogenesis terms supporting a broad developmental role.","confidence":"High","size":21,"edges":9,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0048048","count":11},{"id":"GO:0043010","count":10},{"id":"GO:0060441","count":10},{"id":"GO:0021983","count":9}]},{"hash":"1966794990043100314","title":"DNA repair and stress response","description":"The cluster includes base-excision repair and DNA recombination terms, plus cell cycle regulation (G1/S transition), apoptosis, redox homeostasis, xenobiotic response, and post-transcriptional mRNA regulation. Together these terms point to a module focused on maintaining genomic integrity and coordinating cellular responses to stress, rather than a single isolated pathway\u2014with some peripheral terms like corneocyte development adding minor context. Overall, it reflects genomic maintenance and stress-adaptation functions.","confidence":"High","size":21,"edges":44,"triangles":28,"max_degree":9,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:1903507","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0045454","count":3},{"id":"GO:0043488","count":3},{"id":"GO:1900087","count":3}]},{"hash":"502405191801133584","title":"Unknown","description":"The terms span development, cell cycle, immune activation, apoptosis, and membrane/junction remodeling with no unifying function; the cluster has sparse connections, so no clear shared theme emerges.","confidence":"","size":21,"edges":3,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0060988","count":2},{"id":"GO:0031139","count":2}]},{"hash":"1433257707368353873","title":"Bacterial translation and cell wall biosynthesis","description":"The most frequent GO terms cluster around protein synthesis (translation; ribosome biogenesis) and cell wall-related processes (peptidoglycan biosynthesis, cell wall organization, and cell shape regulation), consistent with prokaryotic cells busy with building ribosomes and constructing their cell wall. A couple of terms appear unrelated (e.g., synaptic potentiation), likely annotation noise, but the core signal supports a combined theme of translation/protein synthesis and peptidoglycan assembly.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:1900273","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0071555","count":1}]},{"hash":"532405742566729583","title":"Unknown","description":"The top terms span insect imaginal disc\u2013related development (antenna morphogenesis, wing hair organization, cell\u2013cell junction assembly) together with RNA processing (exon\u2013exon junction complex disassembly, nonsense-mediated decay) and basic mitochondrial metabolism (proton transport, aerobic respiration). With only one edge and no cohesive, shared function across all terms, there isn\u2019t a clear, single theme tying these proteins together. ","confidence":"","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903045","count":2},{"id":"GO:0048800","count":2},{"id":"GO:1903259","count":1},{"id":"GO:0000184","count":1},{"id":"GO:1902600","count":1}]},{"hash":"1325497903560702426","title":"Angiogenesis and coagulation signaling","description":"This cluster centers on vascular biology: branching in blood vessel morphogenesis, blood coagulation, and regulation of cell-substrate adhesion, with supporting ERK/MAPK signaling and proliferation components. While transcriptional regulation and surface localization appear as additional roles, the strongest recurring theme is proteins involved in angiogenesis and coagulation, suggesting a vascular development/remodeling module.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":4},{"id":"GO:0034394","count":4},{"id":"GO:0001569","count":4},{"id":"GO:0007596","count":3},{"id":"GO:0010811","count":3}]},{"hash":"1614916243407555163","title":"GPCR Signaling & cAMP Regulation","description":"This cluster is driven by GO terms pointing to GPCR-related processes: positive regulation of GTPase activity, GPCR internalization, activation of adenylate cyclase (cAMP signaling), and even visual perception (rhodopsin-related). Additional terms touch on vasoconstriction and heart development, all of which can be modulated through GPCR pathways, suggesting a cohesive GPCR signaling-centered cluster with tissue- and development-related roles.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0002031","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0045907","count":2},{"id":"GO:0001545","count":2}]},{"hash":"82109704421395944","title":"Angiogenesis and fibrinolysis","description":"The top GO terms center on vascular development and remodeling: fibrinolysis, plasminogen activation, Tie signaling, and endothelial migration/angiogenesis. Related terms like skin development and intramembranous ossification suggest concurrent tissue remodeling. Overall, the cluster appears to be regulators of angiogenesis and fibrinolysis.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":4},{"id":"GO:0031639","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0045766","count":3},{"id":"GO:1900159","count":2}]},{"hash":"5337252630267615","title":"Skeletal muscle development and myokine signaling","description":"This cluster is dominated by terms tying to skeletal muscle biology: skeletal muscle cell differentiation and skeletal muscle tissue development, plus swimming as a motor-function readout, and positive regulation of IL-6 production (a well-known myokine) and IL-23 production, suggesting cytokine signaling linked to muscle activity. Ubiquitin-dependent protein turnover and its regulation also align with muscle remodeling processes. While a few terms point to immune signaling (B cell receptor pathway) or nervous system development, the strongest signal centers on muscle development and function, with cytokine involvement. Confidence: Medium","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0035914","count":3},{"id":"GO:2000778","count":2},{"id":"GO:0032747","count":2}]},{"hash":"2200452702484057238","title":"B cell signaling and ubiquitin regulation","description":"The terms cluster around immune functions, including B cell receptor signaling, type 2 immune response, and dendritic cell differentiation, with regulation of IgE isotype switching. Additionally, ubiquitin-dependent protein catabolic process and negative regulation of ubiquitination suggest a role for ubiquitin turnover in modulating immune signaling. A few outlier terms (circadian sleep/wake cycle, gravitropism) exist but do not override the dominant immune/Ubiquitin theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0050853","count":9},{"id":"GO:0048294","count":9},{"id":"GO:0042748","count":9},{"id":"GO:0042092","count":9}]},{"hash":"829015042224946557","title":"Membrane signaling and endosomal trafficking","description":"This cluster shows multiple GO terms tied to membrane-associated processes: PI signaling, endosome maturation and vesicle formation, and ectodomain proteolysis of membrane proteins, plus regulation of cell polarity and shape\u2014together pointing to membrane dynamics and trafficking. A few terms like defense response to virus or bone development are less tightly aligned and may reflect pleiotropy or annotation noise, but overall the common thread is membrane signaling and vesicle trafficking.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":2},{"id":"GO:0055072","count":2},{"id":"GO:0051044","count":2},{"id":"GO:2000769","count":2},{"id":"GO:0060348","count":2}]},{"hash":"114527124780348028","title":"Stress-Responsive Transcription and Immune Signaling","description":"This cluster centers on transcriptional regulation (DNA-templated transcription) and immune/stress response terms (response to immobilization stress, cellular response to lipopolysaccharide, and regulation of TLR4 signaling). The presence of keratinocyte migration and various development terms likely reflects broad transcriptional control across tissues rather than a single tissue-specific function, with xenobiotic metabolism and cobalamin biosynthesis as ancillary processes that can be co-regulated under stress. Overall, the core theme appears to be transcription-driven responses to stress and immune signaling.","confidence":"Medium","size":20,"edges":13,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035902","count":7},{"id":"GO:0006351","count":5},{"id":"GO:0060749","count":5},{"id":"GO:0071222","count":5},{"id":"GO:0051546","count":5}]},{"hash":"1454827368396470667","title":"Developmental signaling and organogenesis","description":"The top GO terms cluster around development across multiple tissues (nervous system development, kidney development, spermatid development, ossification) and central signaling pathways (ERK/MAPK cascade, Roundabout signaling, Hedgehog via Smoothened). This suggests a cohesive theme of developmental signaling and organogenesis, with immune-related terms present but not defining the cluster. ","confidence":"High","size":20,"edges":85,"triangles":100,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":8},{"id":"GO:0007286","count":7},{"id":"GO:0035385","count":7},{"id":"GO:0007411","count":7},{"id":"GO:0007224","count":7}]},{"hash":"1750668119048147879","title":"Developmental signaling and morphogenesis","description":"The cluster shows enrichment for organ development terms (heart, thymus, cartilage condensation) alongside signaling pathways (Wnt, ephrin receptor signaling) and cellular architecture processes (filopodium, tight junctions, centrosome localization, synapse remodeling), suggesting proteins involved in developmental morphogenesis and regulation of signaling rather than a single tissue type.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":3},{"id":"GO:0000186","count":3},{"id":"GO:0048538","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0046847","count":3}]},{"hash":"1559683221178941793","title":"Steroid and Retinoid Lipid Metabolism","description":"The cluster is dominated by lipid and steroid hormone metabolism terms (retinal/retinol, 3-keto-sphinganine, androgen, estrogen), indicating a cohesive theme around sterol/lipid and retinoid pathways. Some antibiotic-related terms appear as outliers, but the lipid/steroid signal is strong, so the label reflects the core function of the group.","confidence":"High","size":20,"edges":150,"triangles":600,"max_degree":19,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":19},{"id":"GO:0042574","count":17},{"id":"GO:0006666","count":17},{"id":"GO:0008209","count":17},{"id":"GO:0046677","count":17}]},{"hash":"1673804168679987928","title":"Neural development and synaptic signaling","description":"The top GO terms cluster strongly around nervous system development, CNS development, and neural signaling pathways (Roundabout and Smoothened signaling), as well as synaptic assembly and ion channel clustering, which together point to neural development and synaptic signaling as the core function of this protein cluster. Some terms (kidney development, endodermal differentiation, T cell receptor signaling) are broader or outliers, but the dominant theme remains neural development and neuronal signaling.","confidence":"Medium","size":20,"edges":177,"triangles":940,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":11},{"id":"GO:0007224","count":11},{"id":"GO:0035385","count":11},{"id":"GO:0001822","count":11},{"id":"GO:0050852","count":10}]},{"hash":"2272199752300053019","title":"Neural crest migration and axon guidance","description":"The GO terms emphasize neural development and precise axon pathfinding, with multiple terms focusing on sympathetic neuron guidance, axon extension, semaphorin-plexin signaling, neural crest migration, trigeminal nerve organization, and branchiomotor neuron guidance. This together suggests a cluster of proteins involved in neural crest\u2013driven migration and axon guidance during nervous system development.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0097491","count":3},{"id":"GO:0097490","count":3},{"id":"GO:1902287","count":3}]},{"hash":"1779995027623284352","title":"Reproductive Development and Fertilization","description":"This cluster centers on mammary gland development and lactation-related processes (lactose biosynthesis, glycosphingolipid biosynthesis, glycosylation) alongside sperm\u2013egg interaction terms (penetration of zona pellucida, regulation of the acrosome reaction, and development of secondary sexual characteristics), plus mammary involution and epithelial remodeling signals. Taken together, the GO terms point to reproductive tissue development, lactation, and fertilization-related functions as the common theme.","confidence":"High","size":20,"edges":28,"triangles":11,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":9},{"id":"GO:0005989","count":7},{"id":"GO:0006486","count":7},{"id":"GO:0006688","count":6},{"id":"GO:0060054","count":6}]},{"hash":"1481897166283857194","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":154,"triangles":704,"max_degree":18,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0006099","count":4},{"id":"GO:0042853","count":4},{"id":"GO:0007219","count":3},{"id":"GO:0097053","count":3},{"id":"GO:0006122","count":3}]},{"hash":"892835235623648262","title":"Biosynthesis of diverse metabolites","description":"Based on the prominent GO terms, this cluster centers on diverse biosynthetic pathways, including antibiotic biosynthesis, retinal metabolism, poly-hydroxybutyrate biosynthesis, and steroid/hormone biosynthesis (glucocorticoids and C21-steroid hormones), as well as tropane alkaloid biosynthesis. These collectively point to production and processing of a wide range of natural products and metabolites. A couple of other terms (like transcription regulation or lung development) are broader or context-specific and do not detract from the core biosynthetic theme.","confidence":"High","size":20,"edges":91,"triangles":171,"max_degree":18,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":11},{"id":"GO:0055114","count":10},{"id":"GO:0006355","count":9},{"id":"GO:0042574","count":9},{"id":"GO:0042619","count":9}]},{"hash":"1976243995184970706","title":"Transcriptional regulation of differentiation and vascular development","description":"This cluster centers on gene expression control during development: DNA-templated transcription and regulation of transcription, along with positive regulation of vasculogenesis and myoblast differentiation, and Notch signaling modulation, suggesting a cohesive theme of transcriptional control guiding differentiation and vascular development. Some hydroxylation and obsolete terms appear peripheral and do not define the core function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0006351","count":7},{"id":"GO:0045746","count":7},{"id":"GO:0042265","count":6},{"id":"GO:0036138","count":6}]},{"hash":"1750822351752952984","title":"Cell Cycle and Growth Signaling","description":"The top GO terms indicate core cell cycle processes (DNA replication, centrosome cycle, nuclear export regulation) alongside growth and development pathways (VEGF signaling, Hippo signaling, cranial skeleton morphogenesis, endothelial migration). This suggests a cluster centered on coordinating cell proliferation with development and vascular growth, rather than a single specialized function. The presence of STAT phosphorylation and virus response hints possible integration with signaling networks during stress or infection.","confidence":"Medium","size":20,"edges":36,"triangles":14,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046827","count":19},{"id":"GO:0007098","count":18},{"id":"GO:0048701","count":18},{"id":"GO:0010571","count":18},{"id":"GO:0006260","count":18}]},{"hash":"629845286828255128","title":"Cartilage ECM Assembly and Adhesion","description":"The GO terms cluster around extracellular matrix formation and remodeling (hyaluronan metabolism, cell-matrix adhesion, protein heterotrimerization) and cartilage-specific development (cartilage condensation, endodermal differentiation), suggesting a cohesive theme of cartilage ECM assembly and adhesion; a few terms relate to immune pathways, but they are less central to the core function.","confidence":"Medium","size":20,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":2},{"id":"GO:0035987","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0060355","count":2}]},{"hash":"787489024463101289","title":"Vertebrate embryonic morphogenesis and organ development","description":"The top terms cluster around vertebrate embryonic development and morphogenesis across multiple organs: eye development/morphogenesis (embryonic eye morphogenesis, camera-type eye development, amacrine cell differentiation), axial and neural tube patterning (left/right pattern formation, floor plate development), and cardiovascular/vascular development (secondary heart field specification, lung vasculature development, vascular wound healing). The transcription by RNA polymerase II term suggests active gene regulation during these programs. Together, they indicate a broad embryonic morphogenesis program affecting eye, neural, heart, and vascular development.","confidence":"High","size":20,"edges":186,"triangles":1070,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0043010","count":9},{"id":"GO:0060441","count":9},{"id":"GO:0048048","count":9},{"id":"GO:0060972","count":7}]},{"hash":"1495930893337985930","title":"Lymphatic and kidney morphogenesis with ECM remodeling","description":"The proteins cluster around lymph vessel morphogenesis and metanephric tubule development, with strong signals for extracellular matrix organization (collagen fibril organization, cartilage condensation) and cell adhesion. Immune-related terms (leukocyte tethering/rolling, complement pathway) and platelet activation suggest coordinated tissue morphogenesis with immune cell interactions and ECM remodeling.","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0036303","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0072237","count":6},{"id":"GO:0072287","count":6},{"id":"GO:0030199","count":5}]},{"hash":"1150308693102671842","title":"GPCR-cAMP Signaling with Immune and Metabolic Roles","description":"The cluster\u2019s top GO terms center on GPCR-mediated activation of adenylate cyclase and cAMP signaling (GO:0022900, GO:0010579, GO:0007190), including positive regulation of blood pressure, which points to cardiovascular regulatory functions. Immune-related terms (TNF and IL-12 production) and other broad phenotypes (temperature response, eating behavior, reproductive process) suggest pleiotropic roles for these GPCR-linked pathways in immune and behavioral/metabolic contexts. The combination supports a cohesive theme around GPCR\u2013cAMP signaling with downstream cardiovascular and immune/metabolic effects, though the presence of other metabolic terms indicates broader functions rather than a single narrow pathway.","confidence":"Medium","size":20,"edges":8,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":16},{"id":"GO:0022900","count":16},{"id":"GO:0010579","count":16},{"id":"GO:0007190","count":15},{"id":"GO:0032720","count":14}]},{"hash":"970415410915754089","title":"Thermogenesis and Vascular Signaling","description":"The cluster is enriched for metabolic/thermogenic cues (temperature response, diet-induced thermogenesis, electron transport chain) and vascular signaling (blood coagulation, blood pressure regulation) with broad signaling involvement (GPCR, Rho) and some inflammation (TNF) and reproduction components, suggesting a systemic metabolic-vascular signaling module rather than a single precise function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":15},{"id":"GO:0007596","count":15},{"id":"GO:0002024","count":15},{"id":"GO:0045777","count":15},{"id":"GO:0022900","count":15}]},{"hash":"1110735697004111726","title":"Circadian Regulation and Immune Signaling","description":"The top GO terms reveal a strong enrichment for circadian processes (regulation of circadian rhythm; circadian sleep/wake cycle) alongside immune signaling (B cell receptor signaling, type 2 immune response, IgE isotype regulation). This suggests the cluster comprises proteins involved in circadian regulation that also participate in immune signaling pathways. Some development-related terms appear as well, which may reflect pleiotropy, but the circadian cluster signal is the most prominent.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0042752","count":8},{"id":"GO:0051260","count":8},{"id":"GO:0050853","count":7},{"id":"GO:0048294","count":7}]},{"hash":"1039585200836341822","title":"Inflammation and Hormone Signaling","description":"The proteins in this cluster show enrichment for inflammatory-related GO terms (inflammatory response, response to lipopolysaccharide) and vascular/inflammatory processes (angiogenesis), as well as signaling-related terms (prolactin signaling, response to estradiol, peptidyl-tyrosine autophosphorylation, cellular response to mechanical stimulus, substrate adhesion-dependent cell spreading). The mix suggests a broader theme of signal transduction involved in immune/inflammatory responses and hormonal signaling, rather than a single tightly defined pathway. Confidence: Medium","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034446","count":3},{"id":"GO:0032496","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0007432","count":2},{"id":"GO:0006954","count":2}]},{"hash":"743750500139164609","title":"Unknown","description":"The GO terms cover ubiquitin-dependent proteolysis, circadian regulation, nervous system and muscle development, and diverse immune signaling, with no single shared pathway linking all proteins. The absence of edges suggests a heterogeneous set rather than a cohesive module, so no clear, specific label can be assigned. ","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0042752","count":9},{"id":"GO:0051260","count":9},{"id":"GO:0007399","count":8},{"id":"GO:0035914","count":8}]},{"hash":"287645885392982014","title":"Bacterial metabolism and biosynthesis","description":"The cluster includes multiple GO terms tied to biosynthesis and metabolism, including antibiotic biosynthesis, LPS/colanic acid cell envelope components, nucleotide sugar metabolism (GDP-mannose), sphinganine metabolism, and nitrogen/sporulation processes, suggesting a broad bacterial metabolic/biosynthetic module.","confidence":"Medium","size":20,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0030435","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0042574","count":1}]},{"hash":"713803900908685689","title":"Energy Metabolism and Translation","description":"The cluster shows enrichment for central energy-related processes (glycolysis, TCA cycle, mitochondrial electron transport) together with translation, rRNA maturation, and other housekeeping activities, suggesting a group comprising core metabolic enzymes alongside protein synthesis machinery. This makes a concise, representative label: Energy Metabolism and Translation.","confidence":"Medium","size":20,"edges":164,"triangles":744,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006099","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0006096","count":2}]},{"hash":"1457627464800357791","title":"Cytoskeletal remodeling and endocytosis signaling","description":"The cluster is dominated by GO terms tied to actin dynamics (filopodium assembly, actin polymerization), vesicle trafficking (endocytosis, endosomal vesicle fusion), and small GTPase signaling (Rap, small GTPase pathways). This points to a cohesive theme of cytoskeletal remodeling coordinated with membrane trafficking, rather than a single pathway, with some sporulation-related assembly likely reflecting conserved cytoskeletal roles. ","confidence":"High","size":20,"edges":38,"triangles":15,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":5},{"id":"GO:0006897","count":4},{"id":"GO:0046847","count":4},{"id":"GO:0051835","count":4},{"id":"GO:0007264","count":4}]},{"hash":"1835775168383635011","title":"Transmembrane Transporters","description":"The cluster is dominated by GO terms describing transport across membranes, including ion (sodium, potassium, phosphate) and sugar (galactose, fucose) transmembrane transport, vitamin and xenobiotic transport, and neurotransmitter loading into synaptic vesicles, pointing to a group of membrane transporter proteins rather than cytosolic enzymes.","confidence":"High","size":20,"edges":47,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":7},{"id":"GO:0006004","count":7},{"id":"GO:0042891","count":7},{"id":"GO:0071805","count":7},{"id":"GO:0098700","count":7}]},{"hash":"858369255571882355","title":"Glycosylation and Immune/Neural Development","description":"The GO terms indicate a focus on glycosylation-related processes (protein glycosylation, N-glycan fucosylation, Lewis a epitope biosynthesis) together with immune and neural development activities (leukocyte migration, regulatory T cell differentiation, neuronal stem cell maintenance, and cortical neuron migration). While RNA processing terms appear, the dominant theme centers on glycosylation-linked development and cell movement across immune and neural contexts, making this a coherent, if broad, cluster label. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034247","count":2},{"id":"GO:0098789","count":2},{"id":"GO:0002522","count":2},{"id":"GO:0036071","count":2},{"id":"GO:0021799","count":2}]},{"hash":"1199614915924114031","title":"Cell Cycle and Division Proteins","description":"This cluster is dominated by GO terms related to the mitotic cell cycle and cell division (mitotic cell cycle, cell division), indicating a core involvement in cell cycle processes. The presence of seemingly unrelated terms (photosynthesis, chlorophyll biosynthesis, prostate gland development) and some obsolete annotations likely reflect cross-species data or annotation noise, but the strongest signal centers on cell cycle functions.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:2001162","count":2},{"id":"GO:1902325","count":2},{"id":"GO:0030850","count":2},{"id":"GO:0051301","count":2}]},{"hash":"73773535244416065","title":"Complement activation and proteolytic remodeling","description":"The top GO terms point to activation of the complement system (classical and lectin pathways) together with proteolytic processes such as plasminogen activation, fibrinolysis, and collagen catabolism. Additional terms like digestion, response to lipopolysaccharide, and angiogenesis regulation suggest an inflammatory and tissue-remodeling context. Taken together, the cluster seems to group proteins involved in protease-driven immune responses and extracellular matrix remodeling.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0031639","count":5},{"id":"GO:0042730","count":5},{"id":"GO:0007586","count":5}]},{"hash":"1930384644168762314","title":"Neural and Muscle Development Signaling","description":"The top GO terms point to development and signaling across nervous and muscular systems, including sympathetic ganglion development, neuron axon guidance, astrocyte activation, regulation of synaptic plasticity, muscle fiber development, and cardiac contraction. They also highlight key signaling pathways (Wnt/calcium, BMP response, Hedgehog via Smoothened). This pattern suggests a cluster of proteins involved in coordinating neural and muscular development and function through multiple signaling cascades, rather than a single precise function. Confidence: Medium","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061549","count":2},{"id":"GO:0045880","count":2},{"id":"GO:0048143","count":2},{"id":"GO:0007223","count":2},{"id":"GO:0071679","count":2}]},{"hash":"1805960905129576384","title":"TNF/IL-6\u2013mediated extrinsic apoptosis and inflammation","description":"The GO terms point to cytokine-driven inflammatory signaling (response to LPS, TNF, IL-6) and regulation (positive/negative regulation) of the extrinsic apoptotic pathway, including signaling in the absence of ligand. This suggests a coherent theme of inflammatory responses connected to extrinsic apoptosis, with some NF-\u03baB-related notes. A few terms (like hippocampus development) appear as outliers, but do not override the main pattern.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0030889","count":2},{"id":"GO:0097192","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0051092","count":2}]},{"hash":"2236794411084307104","title":"Cytoskeleton-Driven Vesicle Trafficking","description":"The GO terms cluster around Golgi localization, phagophore assembly, endosome transport, and filopodium formation, all of which rely on cytoskeletal dynamics and membrane trafficking. Additional terms related to mitotic spindle assembly and cellular response to mechanical stimulus further support a theme of microtubule- and actin-mediated intracellular transport, even though a few items (macrophage differentiation, androgen signaling) are less tightly connected.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043525","count":3},{"id":"GO:0000042","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0034497","count":2}]},{"hash":"1802998646223621584","title":"Cardiac calcium signaling and action potential regulation","description":"This cluster is driven by GO terms emphasizing calcium-mediated regulation of cardiac excitation, including regulation of cardiac muscle contraction via release of sequestered calcium, and the regulation of SA node and atrial action potentials. Calcium-dependent pathways (e.g., calcineurin-NFAT signaling) also appear, supporting a cohesive theme of calcium-governed cardiac electrical activity. Some terms (nuclear import, hypoxia, skin development, ascospore formation) appear as outliers but do not overshadow the core calcium\u2013cardiac signaling pattern.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010881","count":2},{"id":"GO:0098907","count":2},{"id":"GO:0098910","count":2},{"id":"GO:0007205","count":1},{"id":"GO:0005513","count":1}]},{"hash":"2182934963093328686","title":"Hair Follicle and Keratinocyte Development","description":"This cluster\u2019s strongest signals are skin-related: hair follicle morphogenesis, hair cycle, keratinocyte activation/differentiation, and related epidermal maturation terms. While there are outliers (complement activation and axonal transport), the dominant terms point to hair and keratinocyte biology and skin development, supporting this label as representative. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0031069","count":4},{"id":"GO:0048632","count":3},{"id":"GO:0032836","count":3},{"id":"GO:0042633","count":3}]},{"hash":"428486113045779474","title":"RNA and protein methylation","description":"This cluster is enriched for multiple methylation-related GO terms, including RNA guanine-N7 methylation (mRNA capping), tRNA wobble uridine modification, N-terminal peptidyl-glycine methylation, and arginine/peptide methylation, pointing to a common theme of methyltransferase activities modifying RNA and proteins. Some terms (e.g., nodulation, light-independent chlorophyll biosynthesis) may reflect organism-specific roles or noise and do not drive the overall theme. Therefore, label reflects RNA and protein methylation processes.","confidence":"Medium","size":19,"edges":25,"triangles":15,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0009877","count":5},{"id":"GO:0006370","count":5},{"id":"GO:0036068","count":5},{"id":"GO:0036265","count":5},{"id":"GO:1901052","count":5}]},{"hash":"1376379640574303214","title":"Cell-cycle control and kinase signaling","description":"The top GO terms point to mitotic processes (spindle assembly, mitotic cell cycle) and regulation via ubiquitination and phosphorylation (protein serine/threonine kinase activity, autophosphorylation). Additional terms reflect broader signaling and stress responses (hypoxia, GTPase activity) and RNA transport, suggesting a cluster of proteins involved in cell-cycle regulation and modulation of signaling pathways, with some overlap into stress/immune responses.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016567","count":7},{"id":"GO:0090307","count":7},{"id":"GO:0071456","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0035264","count":5}]},{"hash":"1137678496895092492","title":"Cofactor and lipid and antibiotic biosynthesis cluster","description":"The dominant GO terms point to biosynthesis of vitamins and cofactors (cobalamin, biotin, menaquinone), lipids (phosphatidylcholine, sterol), and antibiotics, indicating a metabolic biosynthesis theme. Additional terms for rRNA modification and N-terminal methylation reflect related biosynthetic/modification activities, while xenobiotic response and nodulation suggest a broader bacterial context. Overall, the cluster centers on biosynthetic and modification processes across small molecules and macromolecules, with accessory context-specific terms.","confidence":"Medium","size":19,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":9},{"id":"GO:0009236","count":8},{"id":"GO:0009877","count":7},{"id":"GO:0018013","count":7},{"id":"GO:0009102","count":7}]},{"hash":"255350469772429625","title":"GPCR Signaling and Prostaglandin-Mediated Inflammation","description":"The top terms center on GPCR-mediated signaling (GO:0007213) and prostaglandin biosynthesis (GO:0001516), with receptor clustering and PI3K/AKT pathway regulation, indicating a core theme of cell signaling that links lipid mediators to inflammatory responses. In addition, inflammatory cues (lipopolysaccharide response) and lipid-related metabolism (retinol) are represented, suggesting a signaling network that integrates GPCR signals with prostaglandin/inflammatory processes. While some terms are broader, the dominant theme is GPCR-driven signaling linked to prostaglandin-mediated inflammation.","confidence":"Medium","size":19,"edges":100,"triangles":252,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":12},{"id":"GO:0001516","count":8},{"id":"GO:0051897","count":8},{"id":"GO:0048661","count":8},{"id":"GO:0043113","count":8}]},{"hash":"1209150565880872620","title":"ECM remodeling and cell adhesion","description":"This cluster centers on extracellular matrix processes such as hyaluronan metabolism and cell-matrix/heterotypic adhesion, along with cell migration and metalloprotease activity, all pointing to ECM remodeling. Immune-related terms like complement activation and blood coagulation accompany these processes, suggesting a wound-healing/repair context with developmental potential (dendrite regeneration, endodermal differentiation). Overall, the proteins are best described as involved in ECM remodeling and adhesion during tissue repair and development.","confidence":"High","size":19,"edges":140,"triangles":541,"max_degree":18,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030212","count":6},{"id":"GO:0007161","count":6},{"id":"GO:0007596","count":6},{"id":"GO:1905050","count":6},{"id":"GO:0070208","count":6}]},{"hash":"1582765187059453034","title":"Innate Immunity and Lymphangiogenesis","description":"This cluster is dominated by GO terms pointing to innate immune activity (complement activation via lectin pathway, basophil activation, response to fungal origin, NK cell chemotaxis regulation) and tissue remodeling via lymph vessel morphogenesis. While some ubiquitin/proteostasis and development terms appear, the strongest signal ties immune activation to lymphatic development, suggesting a theme of immune-driven vascular remodeling.","confidence":"High","size":19,"edges":8,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":6},{"id":"GO:0030433","count":5},{"id":"GO:2000157","count":4},{"id":"GO:1903094","count":4},{"id":"GO:0001502","count":4}]},{"hash":"289464919966903015","title":"Biosynthesis and degradation of natural products","description":"The cluster features strong signals for biosynthesis (antibiotic, biotin, methionine) alongside several catabolic or degradation processes (stilbene, uracil, 3-phenylpropionate, alkaloids) and a response to toxic substances, plus a P450 epoxygenase pathway. This combination suggests a cohesive theme around metabolism of natural products and detoxification, encompassing both production and breakdown of diverse organic compounds.","confidence":"Medium","size":19,"edges":9,"triangles":1,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0017000","count":8},{"id":"GO:0009102","count":8},{"id":"GO:0009086","count":8},{"id":"GO:0019740","count":8},{"id":"GO:0019373","count":8}]},{"hash":"1276041402631621236","title":"Unknown","description":"The top GO terms are spread across antibiotic response, defense against Gram-positive bacteria, various metabolic pathways (lipid/sphingolipid/retinal/androgen), and signaling, with no single cohesive process linking all proteins. Therefore there isn\u2019t a clear, representative theme for this cluster.","confidence":"","size":19,"edges":4,"triangles":1,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0046677","count":4},{"id":"GO:0031639","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0035264","count":3}]},{"hash":"1621922724564508954","title":"RNA splicing and post-transcriptional regulation","description":"Top GO terms indicate strong involvement in spliceosome-mediated mRNA splicing, mRNA stability and export, and regulation of translational initiation, plus regulatory ncRNA\u2013mediated gene silencing. These collectively point to a cohesive theme of RNA maturation and post-transcriptional control of gene expression, rather than transcriptional regulation. Therefore, this label best reflects the cluster\u2019s function.","confidence":"High","size":19,"edges":153,"triangles":721,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":15},{"id":"GO:0031047","count":13},{"id":"GO:0048026","count":13},{"id":"GO:0045292","count":13},{"id":"GO:0048025","count":12}]},{"hash":"1952825985604047878","title":"DNA replication and damage response","description":"This cluster centers on core DNA metabolism: DNA replication, unwinding, primer synthesis, and topological changes, with a notable SOS response signal and related genome maintenance terms. A few stress-related terms (innate immune response, hypoxia) appear but do not override the dominant DNA-centric theme, supporting a label of DNA replication and damage response.","confidence":"Medium","size":19,"edges":7,"triangles":0,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0006306","count":5},{"id":"GO:0009432","count":5},{"id":"GO:0006268","count":5},{"id":"GO:0090394","count":5}]},{"hash":"1803770064237621108","title":"Developmental signaling and cytoskeletal regulation","description":"This cluster combines developmental processes (skin development, blastocyst development, response to growth hormone) with cell cycle and robust cytoskeletal dynamics (actin cortical patch assembly, regulation of cell shape) and signaling activities (GTPase activity regulation, kinase regulation). The convergence on growth-related signaling and cytoskeletal remodeling suggests proteins acting in developmental signaling pathways that coordinate cytoskeletal changes.","confidence":"Medium","size":19,"edges":76,"triangles":135,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0060416","count":3},{"id":"GO:0071456","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0001824","count":2}]},{"hash":"1998456413752980126","title":"Neural and Organ Development Signaling","description":"This cluster is enriched for development-related GO terms across multiple tissues (heart, kidney, brain, hippocampus, nervous system) and includes signaling pathways such as ERK, Hippo, and Rho regulation. The common theme is developmental regulation spanning neural and other organ systems, supported by the top terms. ","confidence":"High","size":19,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0001822","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0021766","count":4}]},{"hash":"1206234444123345103","title":"Steroid, retinoid, and prostaglandin metabolism","description":"The top GO terms cluster around metabolic processing and signaling of lipid- and vitamin-derived molecules: retinoic acid catabolism, prostaglandin biosynthesis, androgen metabolism, vitamin D response, and aldosterone-related renal regulation. This points to a set of enzymes involved in the metabolism and signaling of steroids, prostaglandins, retinoids, and vitamins rather than a single pathway. Some terms (e.g., copper ion response, nematode response) are less directly connected, but the dominant theme supports lipid/vitamin hormone metabolism.","confidence":"Medium","size":19,"edges":13,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0034653","count":15},{"id":"GO:0070989","count":15},{"id":"GO:0001516","count":15},{"id":"GO:0060065","count":15},{"id":"GO:0071280","count":15}]},{"hash":"1844810656532299817","title":"Embryonic Organ Development Across Tissues","description":"These proteins show enrichment for embryonic development and morphogenesis across multiple organs (placenta, heart, eye, hindlimb, prostate, habenula, etc.), with neuron maturation also represented. This points to a broad developmental role rather than a single pathway, justifying a label centered on embryonic organogenesis.","confidence":"Medium","size":19,"edges":7,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001890","count":7},{"id":"GO:2000288","count":7},{"id":"GO:0003148","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0048048","count":7}]},{"hash":"1635752620468938179","title":"Neural signaling and plasticity (dopaminergic/ERK)","description":"The cluster is enriched for dopaminergic synaptic transmission, cocaine behavioral response, visual perception/learning, pain perception, and positive regulation of the ERK1/2 cascade, pointing to a common theme of neural signaling and synaptic plasticity, with ERK pathway involvement. While some terms relate to immune or developmental processes, the dominant signals are neural and signaling-oriented, making this a coherent neural-plasticity module.","confidence":"Medium","size":19,"edges":18,"triangles":1,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010759","count":10},{"id":"GO:0048148","count":10},{"id":"GO:0001963","count":10},{"id":"GO:0006468","count":10},{"id":"GO:0007601","count":10}]},{"hash":"2005367329141815976","title":"Dopaminergic signaling and autonomic vascular regulation","description":"The top terms point to nervous system signaling (pain perception, dopaminergic synaptic transmission, cocaine response, temperature perception) and autonomic control of vasculature (vasoconstriction, blood pressure), with accompanying energy metabolism (electron transport chain) that supports neuronal activity. Some immune interaction (macrophage chemotaxis) appears but does not define the cluster, so the core theme remains neurovascular signaling with metabolic support.","confidence":"Medium","size":19,"edges":7,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0071502","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0045907","count":4},{"id":"GO:0043547","count":4}]},{"hash":"2238781145006769028","title":"Unknown","description":"The top GO terms span immune signaling (complement pathways, membrane attack complex), cell adhesion and integrin regulation, neural development, endocrine/metabolic processes, and even photosynthesis, with no shared biological theme. The graph has no edges or interactions, indicating no cohesive function tying these proteins together. Therefore, there is no reliable single label to assign. ","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0007160","count":4},{"id":"GO:0051006","count":3},{"id":"GO:0006590","count":3},{"id":"GO:0007597","count":3},{"id":"GO:0002430","count":3}]},{"hash":"1835601686360365804","title":"Ubiquitin-Dependent Immunity and Cell Cycle Regulation","description":"GO terms emphasize ubiquitin-related processes (K63-linked ubiquitination, ubiquitin-dependent proteolysis, ERAD, APC-dependent catabolic) together with innate immune defense and viral response. The co-occurrence of antiviral defense and mitotic/cell-cycle terms suggests a shared theme of ubiquitin signaling coordinating immune responses with cell-cycle control.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0051301","count":5},{"id":"GO:0051607","count":5},{"id":"GO:0000278","count":5},{"id":"GO:1902187","count":5}]},{"hash":"74585442263965597","title":"Neuronal development and synapse formation","description":"Top GO terms point to neural development and synaptic organization: positive regulation of synapse assembly, serotonergic neuron axon guidance, neuronal stem cell maintenance, and broader neuronal development. There is also emphasis on cell adhesion and migration, consistent with neural circuit formation. A few terms reference non-neural contexts (endothelial barrier establishment, endocardial cushion formation, B cell differentiation), which may reflect broader protein functions or annotation noise. Overall, the dominant theme is neural development and synapse formation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":5},{"id":"GO:0007157","count":5},{"id":"GO:1903142","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0055114","count":4}]},{"hash":"643060332292074834","title":"GPCR signaling and vesicle trafficking","description":"The top terms cluster around thrombin-activated receptor signaling (a GPCR), regulation of Rho signaling, and late endosome to Golgi transport, suggesting a shared role in receptor-driven signaling linked to vesicle trafficking and cytoskeletal dynamics; transcription-related terms appear less central.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034499","count":2},{"id":"GO:0070493","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0090309","count":1},{"id":"GO:0002674","count":1}]},{"hash":"192239393207929920","title":"Neuronal endosomal trafficking and axon targeting","description":"This cluster is dominated by GO terms tied to endosomal transport (endosome to lysosome, early to late endosome) and vesicle trafficking to the Golgi, alongside neural development processes such as neural tube closure and axon target recognition, suggesting a cohesive role in neuronal vesicle movement and axon guidance. A few secondary terms (platelet aggregation, exocytosis regulation, RNA Pol II regulation) are present but less central to the main theme. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":2},{"id":"GO:0008333","count":2},{"id":"GO:0045022","count":2},{"id":"GO:0031397","count":2},{"id":"GO:0001843","count":2}]},{"hash":"1982247936185749915","title":"Synaptic Exocytosis and Membrane Trafficking","description":"Top GO terms cluster around intracellular protein transport, ER membrane organization, and fast calcium-dependent exocytosis of neurotransmitters, with signals of GABAergic synaptic regulation and presynaptic signaling. This combination points to a theme of vesicle trafficking and secretion in a synaptic-like context, complemented by protein turnover in secretory compartments. While a few terms reflect broader or non-neuronal processes, the core appears to be the secretory pathway linked to neurotransmission.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006886","count":2},{"id":"GO:0099526","count":2},{"id":"GO:0030579","count":2},{"id":"GO:0032443","count":2},{"id":"GO:0032228","count":2}]},{"hash":"2293310719540244202","title":"Differentiation and signaling in epithelial and immune cells","description":"The top GO terms span differentiation of multiple epithelial lineages (keratinocyte, mammary gland epithelium, embryonic digits) as well as immune-related processes (cytokine signaling, myeloid dendritic cell differentiation) and include metabolic regulation (insulin signaling, glucose transport). This suggests a broad theme around cell fate decisions and intercellular signaling across tissues rather than a single cohesive pathway, making the cluster only loosely connected. Confidence is Low.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046627","count":3},{"id":"GO:0042733","count":3},{"id":"GO:0060644","count":2},{"id":"GO:0019221","count":2},{"id":"GO:0030216","count":2}]},{"hash":"1390911782128662045","title":"Unknown","description":"The terms span immune signaling (B cell receptor signaling), development (nervous system and skeletal muscle), dendritic cell differentiation, structural organization (sarcomere), virus response, endothelial cell migration, and several signaling pathways (STAT phosphorylation, VEGF receptor signaling, Hippo). There isn\u2019t a single cohesive function tying these proteins together, suggesting a non-specific or mixed cluster.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0007519","count":3},{"id":"GO:2001200","count":2},{"id":"GO:0045214","count":2}]},{"hash":"1564202206588939476","title":"Rho GTPase\u2013Actin Dynamics in Morphogenesis","description":"This cluster is driven by GO terms pointing to regulation of GTPase activity and Rho signaling, actin cytoskeleton remodeling (including filament depolymerization and cytoskeleton dynamics), and morphogenetic processes like dendritic spine morphogenesis and axial mesoderm formation. There are also links to broader signaling and mitotic processes, but the strongest theme is cytoskeletal remodeling governed by Rho GTPases that underlies cell shape changes and developmental morphogenesis.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0000278","count":3},{"id":"GO:0090263","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0048320","count":2}]},{"hash":"383268584894124644","title":"Developmental signaling and cell cycle control","description":"The cluster contains GO terms pointing to development and differentiation (multicellular organism development; Bergmann glial cell differentiation) and to cell cycle regulation (negative regulation of CDK activity; protein localization to kinetochore), plus apoptotic regulation and various signaling pathways (insulin receptor signaling, T cell receptor signaling). This combination suggests a cohesive theme around growth, fate specification, and proliferation control in metazoans, hence the label.","confidence":"Medium","size":18,"edges":24,"triangles":11,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043065","count":11},{"id":"GO:0034501","count":11},{"id":"GO:0045736","count":11},{"id":"GO:0007275","count":10},{"id":"GO:0008285","count":10}]},{"hash":"876167406459568076","title":"Bacterial LPS and exopolysaccharide biosynthesis","description":"The strongest GO signals are lipopolysaccharide biosynthetic process and extracellular polysaccharide biosynthetic process, suggesting a core function in assembling components of the bacterial cell envelope. Other terms (translation, various metabolic processes) are present but less coherent with the envelope biosynthesis theme, so the label centers on the most representative function. ","confidence":"Medium","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0016226","count":3},{"id":"GO:0019346","count":2},{"id":"GO:0051782","count":2},{"id":"GO:0018108","count":2}]},{"hash":"485410778319747054","title":"Nuclear RNA Processing and Ribosome Biogenesis","description":"The cluster is dominated by GO terms tied to nuclear RNA processing (transcription termination, spliceosome-mediated regulation of mRNA splicing, and mRNA export) and ribosome biogenesis (ribosomal large subunit assembly, rRNA maturation). While viral genome replication and DNA replication appear among the terms, the strongest, most frequent signals are RNA processing and ribosome assembly processes, suggesting a coherent theme around nuclear RNA maturation and ribosome production.","confidence":"High","size":18,"edges":138,"triangles":617,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0019079","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0006369","count":5},{"id":"GO:0031047","count":4},{"id":"GO:0006605","count":4}]},{"hash":"84372256305816038","title":"Embryonic Development and Growth Regulation","description":"Most terms cluster around regulation of growth and development: regulation of cell growth, embryonic development (in utero), chondrocyte differentiation/proliferation, lung development, and angiogenesis. Additional terms touch on neural synapse assembly and nitric oxide signaling, with a note on immune-related activation of complement. Taken together, they point to proteins involved in coordinating tissue development and organogenesis, particularly in cartilage and vasculature, with ancillary neural and immune roles. ","confidence":"Medium","size":18,"edges":16,"triangles":1,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001558","count":5},{"id":"GO:0032331","count":4},{"id":"GO:0001701","count":4},{"id":"GO:0051965","count":4},{"id":"GO:2001027","count":4}]},{"hash":"648953094926056771","title":"Neuronal axon guidance and synaptic signaling","description":"The proteins cluster around neural signaling and connectivity: ephrin receptor signaling, ROBO pathways, Wnt signaling, and regulation of synapse structural plasticity, along with dopamine response and regulation of axonogenesis, plus focal adhesion dynamics. This combination points to networks governing axon guidance during development and activity-dependent synaptic remodeling.","confidence":"High","size":18,"edges":58,"triangles":33,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043366","count":9},{"id":"GO:1903351","count":9},{"id":"GO:0051835","count":9},{"id":"GO:0048013","count":9},{"id":"GO:0050771","count":9}]},{"hash":"544376825529493368","title":"Vertebrate organogenesis","description":"The top GO terms cluster around embryonic development across multiple organs and systems (midbrain, pancreas, cranial skeleton, palate, pituitary, cartilage, osteoblasts, heart outflow tract, uterus) with an emphasis on transcriptional regulation, suggesting these proteins collectively participate in vertebrate organ formation and broader developmental regulation.","confidence":"High","size":18,"edges":46,"triangles":33,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0030901","count":8},{"id":"GO:0031016","count":8},{"id":"GO:0048701","count":8},{"id":"GO:0060021","count":8}]},{"hash":"1961379451726169078","title":"Tissue-specific developmental gene regulation","description":"This cluster centers on developmental processes across multiple tissues (retina, osteoblasts, skeletal muscle) and ties them to transcriptional and chromatin-level control (RNA polymerase II transcription, rDNA heterochromatin formation). While a few terms are peripheral ( xenobiotic response, MHC II biosynthesis), the dominant theme is regulation of development through transcription and chromatin mechanisms. ","confidence":"Medium","size":18,"edges":135,"triangles":567,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":4},{"id":"GO:0002087","count":4},{"id":"GO:0002076","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0007519","count":4}]},{"hash":"699583859093564262","title":"Vertebrate Developmental Regulation and Genome Maintenance","description":"The cluster includes GO terms tied to vertebrate development (lens fiber differentiation, neural tube closure, skeletal system development) as well as transcription and genome maintenance processes (DNA-templated transcription, DNA repair, tRNA processing). This combination suggests proteins involved in developmental gene regulation alongside genome maintenance, with additional regulatory and stress-response signals (negative regulation of cell proliferation, innate immune response). ","confidence":"Medium","size":18,"edges":3,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0070306","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0001501","count":3}]},{"hash":"2171919826584432784","title":"Developmental organogenesis and transcription regulation","description":"The cluster is enriched for transcription-related GO terms (DNA-templated transcription; negative regulation of transcription by RNA polymerase II) alongside numerous organogenesis/differentiation terms (endocrine pancreas development, skeletal muscle differentiation, embryonic digestive tract morphogenesis, neural crest cell migration, ureteric bud branching, neural tube patterning, etc.), indicating proteins involved in developmental differentiation and morphogenesis with a core role in transcriptional control.","confidence":"High","size":18,"edges":75,"triangles":176,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0031018","count":9},{"id":"GO:0035914","count":8},{"id":"GO:0048557","count":6},{"id":"GO:0000122","count":6}]},{"hash":"1372763620190420598","title":"Endocytic trafficking and receptor transport","description":"This cluster centers on GO terms for endocytosis, endosome localization, endocytic recycling, and Golgi-to-plasma-membrane transport, including neurotransmitter receptor trafficking from endosome to the postsynaptic membrane, indicating a cohesive role in vesicle trafficking and membrane localization of receptors; ancillary terms related to actin dynamics and cell movement support this trafficking-centric theme.","confidence":"High","size":18,"edges":14,"triangles":2,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006893","count":9},{"id":"GO:0010796","count":9},{"id":"GO:0032456","count":9},{"id":"GO:0006897","count":8},{"id":"GO:0098887","count":8}]},{"hash":"318658318694043935","title":"Unknown","description":"The top terms span several unrelated biological areas (fertilization, neural development and synapse maturation, immune/complement pathways, PKC and GTPase signaling, phagolysosome formation, protein heterotrimerization, coagulation, and aging), suggesting no coherent, shared function linking all proteins in this cluster. Therefore there isn\u2019t a clear, representative label beyond Unknown. ","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007338","count":6},{"id":"GO:0021680","count":4},{"id":"GO:0060074","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0090036","count":4}]},{"hash":"66429718674647752","title":"Developmental transcriptional regulation","description":"Top GO terms center on DNA-templated transcription and various developmental regulatory processes (positive regulation of myoblast differentiation, negative regulation of Notch signaling, positive regulation of vasculogenesis). While several entries are obsolete and one term relates to lipopolysaccharide biosynthesis (likely annotation noise), the overall signal points to proteins involved in transcriptional control during development, especially muscle and vascular differentiation. The absence of edges suggests these proteins may act in diverse contexts or be co-annotated rather than functionally connected in this dataset.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0045663","count":8},{"id":"GO:0055114","count":7},{"id":"GO:0042265","count":7},{"id":"GO:0045746","count":7}]},{"hash":"1056805176111214798","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":75,"triangles":145,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031047","count":4},{"id":"GO:0048026","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0006406","count":4},{"id":"GO:0045944","count":3}]},{"hash":"1909515738726143392","title":"Neural development with axon fasciculation and angiogenesis","description":"The cluster is enriched for neural development signals (sensory pain perception; fasciculation of motor and sensory axons) along with developmental processes like angiogenesis and cartilage formation, plus transcription and hormone-response activities, suggesting a cohesive theme of embryonic neural tissue formation and connectivity with supporting tissues. Confidence: Medium","confidence":"","size":18,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0006813","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0046827","count":7}]},{"hash":"45571199100146103","title":"DNA Replication and Mitosis Regulation","description":"Based on the enrichment of terms related to DNA replication, centrosome cycle, kinetochore localization, CDK regulation, and transcription, this cluster appears to capture core cell cycle control and DNA synthesis/mitosis processes. Tissue development terms (placenta, thymus) may reflect broader developmental contexts but do not define the core function of the cluster.","confidence":"High","size":18,"edges":53,"triangles":110,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001890","count":14},{"id":"GO:0048538","count":14},{"id":"GO:0000187","count":14},{"id":"GO:0071276","count":14},{"id":"GO:0034501","count":14}]},{"hash":"419570694204826704","title":"Metabolic Biosynthesis and Stress Response","description":"The top GO terms span several biosynthetic processes (menaquinone, biotin, phylloquinone) and a range of stress-related functions (oxidative stress response, cellular oxidant detoxification, vacuolar acidification) along with a few more diverse processes (tRNA methylation, growth, and even complement activation). This mix suggests proteins involved in core metabolic biosynthesis of cofactors coupled with general cellular maintenance and stress responses, rather than a single cohesive pathway. Therefore, a broad label like \"Metabolic Biosynthesis and Stress Response\" best captures the apparent theme, though some terms indicate scattered functions.","confidence":"Medium","size":18,"edges":147,"triangles":725,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0034599","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0009102","count":2}]},{"hash":"1004122097187292613","title":"Membrane Transporters","description":"These proteins are enriched for transmembrane transport GO terms across a variety of substrates (xenobiotics, vitamins, ions like potassium and sodium, nitrate, sialic acid, fucose). The common function appears to be membrane transport of diverse solutes, consistent with a cluster of transporter proteins rather than a single substrate pathway.","confidence":"High","size":18,"edges":7,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006855","count":14},{"id":"GO:0035461","count":14},{"id":"GO:0071805","count":12},{"id":"GO:0042908","count":11},{"id":"GO:0042128","count":11}]},{"hash":"1232249561970842801","title":"Neurovascular signaling and remodeling","description":"The top terms mix neural development and function (Purkinje cell layer organization, glutamatergic synaptic transmission) with vascular remodeling and coagulation, plus adhesion and survival signals (cell\u2013matrix adhesion, anoikis regulation). This pattern points to coordinated neurovascular development and remodeling, with supporting roles for tissue adhesion and Notch-related signaling. Confidence: Medium","confidence":"","size":18,"edges":21,"triangles":7,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045746","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0021693","count":4},{"id":"GO:0030216","count":4},{"id":"GO:0048661","count":4}]},{"hash":"101030060318447476","title":"Lipid and Hormone Metabolism","description":"This cluster is dominated by GO terms for metabolism of lipid- and hormone-derived molecules, including retinal and retinol metabolism, sphingolipid (3-keto-sphinganine) metabolism, and biosynthesis of androgens and estrogens, pointing to a shared theme of lipid/hormone metabolism. A few terms relate to antibiotics and an obsolete oxidation-reduction term, which are less cohesive with the main theme, so the label is a best-fit but with moderate confidence.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0042574","count":5},{"id":"GO:0006666","count":5},{"id":"GO:0008209","count":5},{"id":"GO:0046677","count":5}]},{"hash":"1989713659940152291","title":"Dopaminergic Neural Signaling and Cardiovascular Function","description":"The cluster centers on dopaminergic synaptic transmission, GPCR signaling via adenylate cyclase, and behavioral responses to cocaine, indicating a dopamine-driven neural signaling theme. Additional terms touch on cardiovascular regulation (blood pressure, heart development) and visual processing, suggesting these proteins participate in broader neural networks influencing both sensory and autonomic functions. While metabolism-related terms appear (electron transport chain, phosphorylation), they can be part of overall neuronal activity and signaling. Medium","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":9},{"id":"GO:0022900","count":9},{"id":"GO:0010579","count":9},{"id":"GO:0010759","count":8},{"id":"GO:0048148","count":8}]},{"hash":"240245663348411396","title":"Unknown","description":"The top GO terms span neural development (Purkinje cell layer development, synapse maturation), immune signaling (complement activation, lectin pathway), cell signaling regulation, extracellular matrix interactions, and metabolism (hyaluronan, lipoprotein lipase, thyroid hormone generation). The diverse and seemingly unrelated processes, combined with zero edges/triangles, indicate no single cohesive function tying the proteins together. Therefore, a specific, representative label cannot be confidently assigned.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0021680","count":5},{"id":"GO:0007338","count":5},{"id":"GO:0060074","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0090036","count":5}]},{"hash":"1442521234847369235","title":"Angiogenesis and Endothelial Regulation","description":"The cluster is dominated by terms tied to blood vessel formation and endothelial cell behavior\u2014angiogenesis, endothelial migration, Tie signaling, plasminogen activation, and platelet aggregation\u2014titting together as vascular remodeling and endothelial survival. A neuronal term is present but appears to be an outlier; overall the vascular theme is strong and representative of the cluster\u2019s function.","confidence":"High","size":18,"edges":24,"triangles":12,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":4},{"id":"GO:2000352","count":4},{"id":"GO:0051968","count":4},{"id":"GO:1902042","count":4},{"id":"GO:0048014","count":3}]},{"hash":"962926170458273150","title":"Neural development and sensory signaling","description":"The top GO terms are dominated by neural-related functions: sensory perception of sound, vocalization behavior, and dendrite development, which together point to neuronal development and sensory processing. The other terms reference lipid metabolism and signaling (cholesterol/ergosterol biosynthesis, arachidonate secretion, LDL particle response) and ERK signaling, suggesting a context of membrane-lipid\u2013associated neural signaling. The mixed signals and lack of interaction evidence (edges) reduce cohesion, so the label reflects the strongest neural theme with a note of possible lipid-signaling context. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0071625","count":2},{"id":"GO:0016358","count":2},{"id":"GO:0006695","count":2},{"id":"GO:0006696","count":2}]},{"hash":"1930245899710445376","title":"Ubiquitin-Regulated Circadian and Neural Signaling","description":"The cluster is enriched for ubiquitin-dependent protein catabolic processes and regulation of ubiquitination, along with circadian rhythm and nervous system development terms, suggesting a core theme of protein turnover modulating circadian and neural signaling. Peripheral terms like B cell receptor signaling and glucosinolate catabolism appear less central but do not contradict the main connection.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0042752","count":7},{"id":"GO:0051260","count":7},{"id":"GO:0050853","count":6},{"id":"GO:0042748","count":6}]},{"hash":"1251852572767693815","title":"Neural development and axon connectivity","description":"Most GO terms point to nervous system development, neural crest migration, axon fasciculation, myelination, synapse assembly, and sodium channel clustering, suggesting a role in neural development and neuronal connectivity. A few terms like heart development are less representative, but the dominant theme is neural maturation and network formation.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0045162","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0036486","count":2},{"id":"GO:0051965","count":2}]},{"hash":"1233721628272894465","title":"Biosynthetic Pathways and Xenobiotic Response","description":"The top GO terms point to a collection of biosynthetic processes (biotin, phosphatidylcholine, sterol, antibiotic biosynthesis) alongside cellular responses to xenobiotics and aging/senescence, suggesting the proteins collectively participate in broad metabolic biosynthesis with accompanying stress response functions rather than a single, cohesive pathway like a specific signaling or structural module.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009877","count":4},{"id":"GO:0009102","count":3},{"id":"GO:0006656","count":3},{"id":"GO:0016126","count":3},{"id":"GO:0017000","count":3}]},{"hash":"426013483081750051","title":"dsRNA Sensing and Interferon/NF-kappaB Signaling","description":"This cluster centers on innate antiviral sensing of dsRNA via MDA-5 (RLR) and downstream signaling that activates NF-kappaB and drives interferon and IL-6 production. GO terms include MDA-5 signaling pathway, cellular response to exogenous dsRNA, regulation of type I/III interferon production, and NF-kappaB activation, supporting a cohesive dsRNA-triggered immune response. A couple of peripheral terms (ER vesicle fusion, sumoylation) are present but do not define the core theme.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007250","count":2},{"id":"GO:0048279","count":1},{"id":"GO:0034344","count":1},{"id":"GO:0032480","count":1},{"id":"GO:0032755","count":1}]},{"hash":"45287672404276632","title":"Glycoprotein biosynthesis and epithelial polarity","description":"This cluster centers on glycosylation and surface-related molecules (O-linked glycosylation via hydroxyproline, arabinogalactan protein metabolism, Lewis a epitope biosynthesis, poly-N-acetyllactosamine biosynthetic process) and processes governing epithelial polarity and adhesion (maintenance of polarity of follicular epithelium, follicle cell adhesion). Some terms reflect broader plant and insect development involving surface glycoproteins, reinforcing a theme where glycan modifications modulate cell-surface interactions during development.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":3},{"id":"GO:0030311","count":2},{"id":"GO:0042248","count":2},{"id":"GO:0007299","count":2},{"id":"GO:0018258","count":2}]},{"hash":"672201071064441402","title":"Innate antiviral defense and cytoskeletal remodeling","description":"These proteins are enriched for innate immune response and defense against virus, with autophagy and cytoskeletal changes (actin filament bundle assembly, cell migration) suggesting remodeling of cell architecture during antiviral responses. Terms related to epithelial polarity and regulation of LPS signaling further support a host-defense role, including antiviral mechanisms that involve intracellular transport modulation. Overall, the cluster reflects innate antiviral immunity linked to cytoskeletal dynamics.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":4},{"id":"GO:0045087","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0090162","count":3}]},{"hash":"924238547488176724","title":"Cytoskeletal Regulation in Neural Development","description":"The top GO terms emphasize microtubule dynamics and organization (cytoplasmic microtubule organization; regulation of microtubule polymerization/depolymerization), along with neural development processes (axonogenesis; cellular response to nerve growth factor). Together these suggest a coherent theme centered on cytoskeletal remodeling during neural differentiation and axon growth. Some terms (lipopolysaccharide response, heart development) are present but appear less representative of the cluster\u2019s core function.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0031122","count":1},{"id":"GO:0031117","count":1}]},{"hash":"682880716110281131","title":"Angiogenesis and Endothelial Signaling","description":"The cluster shows strong emphasis on vascular growth and endothelial function, with GO terms for angiogenesis and positive regulation of angiogenesis, vasoconstriction regulation, and negative regulation of endothelial apoptosis. Additional terms point to growth factor\u2013mediated responses (EGF, GM-CSF) and fibroblast migration, all of which fit a vascular remodeling/angiogenic signaling context. A few terms touch on immune and lipid transport processes, which are less central to the core theme but may reflect broader cross-talk.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045907","count":3},{"id":"GO:2000352","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0001782","count":2},{"id":"GO:0071364","count":2}]},{"hash":"979715930132336932","title":"Cardiovascular development and cell adhesion","description":"Most frequent terms point to heart development and morphogenesis (outflow tract, heart development), with related signaling (integrin signaling) and adhesion (cell adhesion) plausible for vascular/muscle migration. A few terms (photoreception, lateral root branching, ammonium transport) are unrelated to this theme and may reflect noisy annotations.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003151","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0050908","count":2},{"id":"GO:0043652","count":2},{"id":"GO:0007155","count":2}]},{"hash":"300092865904186574","title":"ER Proteostasis and Developmental Signaling","description":"This cluster emphasizes ER protein folding and redox balance (proteostasis), together with developmental and signaling terms such as ureteric bud morphogenesis, male gonad development, Wnt signaling, and parathyroid hormone response, suggesting a theme where ER quality control intersects with developmental signaling pathways.","confidence":"Medium","size":18,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0045454","count":3},{"id":"GO:0034975","count":3},{"id":"GO:0001658","count":3},{"id":"GO:0008584","count":3}]},{"hash":"1977705379772143343","title":"Cardiovascular development","description":"This cluster centers on heart and vascular development; strong terms for heart development, endothelium development, outflow tract morphogenesis, and septum primum development point to proteins involved in cardiac morphogenesis. Additional terms like phosphatidylinositol-mediated signaling and positive regulation of GTPase activity fit signaling events guiding cell behavior during heart and vessel formation. A few outliers (e.g., sporulation-related membrane formation) exist, but the predominant theme is cardiovascular development.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0048015","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0032120","count":2}]},{"hash":"554244640378993438","title":"Angiogenesis and vascular remodeling","description":"Top GO terms cluster around ECM organization, coagulation/fibrinolysis, and vascular development (collagen fibril organization, proteoglycan biosynthesis, plasminogen activation, fibrinolysis; angiogenesis, Tie signaling, platelet aggregation, regulation of endothelial migration). This suggests a vascular remodeling module with ECM dynamics and coagulation components driving blood vessel formation and maintenance.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":5},{"id":"GO:0030210","count":5},{"id":"GO:0031639","count":5},{"id":"GO:0045766","count":5},{"id":"GO:0001867","count":5}]},{"hash":"958596179381867298","title":"Coagulation and immune signaling","description":"The top GO terms center on coagulation and immune processes\u2014plasminogen activation, blood coagulation, and regulation of fibrinogen levels, along with complement activation (lectin pathway) and negative regulation of IL-8 production. These point to a cohesive cluster involved in coagulation cascades and innate immunity. The presence of transcriptional regulation and Wnt signaling terms seems ancillary or regulatory rather than core to this module, but do not override the dominant coagulation/immune theme.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0031639","count":4},{"id":"GO:0016055","count":4},{"id":"GO:0042127","count":4},{"id":"GO:0007596","count":4}]},{"hash":"392240854109922743","title":"Retinoid and prostaglandin/steroid metabolism","description":"The dominant GO terms center on retinol/retinal metabolism and prostaglandin/steroid hormone biosynthesis, indicating a core role in vitamin A processing and lipid-derived signaling molecule production. Other shared terms touch on related metabolic pathways (glucuronate, fructose) and development, supporting a broad metabolic cluster with emphasis on retinoid and prostaglandin/steroid metabolism. Confidence: Medium","confidence":"","size":17,"edges":135,"triangles":665,"max_degree":16,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0042572","count":11},{"id":"GO:0055114","count":11},{"id":"GO:0046370","count":10},{"id":"GO:0042574","count":8},{"id":"GO:0071799","count":7}]},{"hash":"2009868473999059358","title":"Regulatory signaling and cell cycle processes","description":"GO terms center on regulation of signaling components (kinases, GTPases, autophosphorylation) plus related processes (hypoxic response, mRNA transport, synaptic plasticity, and proliferation). The common thread is broad regulatory control of signaling and cell-cycle activities rather than a single pathway.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0071456","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0051028","count":4},{"id":"GO:0006469","count":4}]},{"hash":"167493800426874935","title":"Cardiac action potential regulation (atrial/SA node)","description":"The cluster is dominated by GO terms tied to heart electrophysiology, especially regulation of atrial and SA node action potentials and associated membrane depolarization/repolarization, indicating a shared role in cardiac electrical activity. Other terms (pain, temperature response, transcription) are present but secondary to the cardiac rhythm theme.","confidence":"High","size":17,"edges":13,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0098910","count":6},{"id":"GO:0019233","count":5},{"id":"GO:0098907","count":5},{"id":"GO:0060307","count":5},{"id":"GO:0071502","count":4}]},{"hash":"272554914821259280","title":"Proteostasis and stress-responsive developmental signaling","description":"This cluster centers on protein quality control and stress-responsive regulation that intersect with signaling and development. GO terms highlight nuclear ubiquitin-proteasome\u2013mediated quality control, post-translational targeting to membranes, and modulation of protein kinase activity, which together indicate proteostasis-driven control of signaling. Additional terms on mRNA stability under stress and redox homeostasis reflect cellular stress responses, while mesoderm formation anchors the theme in developmental biology. Overall, the proteins appear linked by coordinated proteostasis and stress-regulated signaling during development.","confidence":"Medium","size":17,"edges":133,"triangles":638,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0010610","count":4},{"id":"GO:0090084","count":3},{"id":"GO:0071374","count":3},{"id":"GO:0045454","count":3},{"id":"GO:0006469","count":3}]},{"hash":"136943635255955219","title":"Cardiac and neural development regulators","description":"The proteins are enriched for developmental regulators affecting both heart formation (valve formation via endocardial cushion EMT, septum morphogenesis, vascular smooth muscle development) and neural differentiation (retina development, neuroblast fate, noradrenergic neuron fate), with accompanying transcriptional regulatory activities. This co-occurrence supports labeling the cluster as Cardiac and neural development regulators.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060766","count":17},{"id":"GO:0045668","count":17},{"id":"GO:0060948","count":15},{"id":"GO:0060411","count":15},{"id":"GO:2000981","count":15}]},{"hash":"69333640325665852","title":"Unknown","description":"The top GO terms are diverse and span fertilization, chromatin methylation (obsolete terms), skin development, cilium assembly, vesicle transport, cytoskeletal dynamics, phagolysosome assembly, protein complex formation, and cytokinesis. There is no single coherent function or pathway connecting these terms, so a generic Unknown label is most appropriate.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":4},{"id":"GO:0061087","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0060271","count":3},{"id":"GO:0006888","count":3}]},{"hash":"1549856367206165376","title":"Eye and neural development","description":"Most terms point to morphogenesis and development of the nervous system and eye (e.g., camera-type eye development, embryonic eye morphogenesis, forebrain development, motor neuron axon guidance, peripheral nervous system axonogenesis), with supporting signals for multicellular organism development and heart patterning. This suggests a cohesive function in vertebrate ocular and neural development.","confidence":"High","size":17,"edges":56,"triangles":69,"max_degree":12,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0007160","count":7},{"id":"GO:0055114","count":7},{"id":"GO:0003016","count":7},{"id":"GO:0060971","count":6},{"id":"GO:0043010","count":6}]},{"hash":"331681302841684021","title":"Unknown","description":"Top GO terms are highly varied, including blood coagulation, tRNA processing, nodulation, multiple biosynthetic pathways (biotin, menaquinone, phosphatidylcholine, sterol), ribosomal RNA modification, and antibiotic biosynthesis. With zero edges and no clear cohesive motif across proteins, there is no single functional theme linking the cluster. As a result, a reliable, concise label cannot be assigned.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0008033","count":2},{"id":"GO:0009877","count":1},{"id":"GO:0018013","count":1},{"id":"GO:0009102","count":1}]},{"hash":"1384057672915201442","title":"Viral Translation Initiation and Reinitiation","description":"The top terms are dominated by translation-related processes: translation reinitiation, formation of translation preinitiation complex, and regulation of translational initiation, including IRES-dependent viral initiation and viral termination-reinitiation. Although there are also RNA processing terms (splicing, polyadenylation) present, the strongest signal centers on initiation and reinitiation of translation, with viral-specific initiation being prominent. This supports labeling the cluster as translation-initiation\u2013oriented, with emphasis on viral mechanisms.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":11},{"id":"GO:0001731","count":11},{"id":"GO:0006446","count":10},{"id":"GO:0075522","count":10},{"id":"GO:0075525","count":10}]},{"hash":"1795986221203118121","title":"Post-translational modification and membrane trafficking regulators","description":"The top GO terms emphasize protein deubiquitination and sumoylation (PTMs) alongside membrane trafficking processes (tail-anchored ER insertion, GPCR internalization) and signaling-related dynamics (mitochondrial fusion, calcium channels). This pattern suggests a cluster of proteins that regulate cellular signaling and protein localization through PTMs and trafficking mechanisms.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":9},{"id":"GO:0016925","count":6},{"id":"GO:0010637","count":5},{"id":"GO:1901340","count":5},{"id":"GO:0006357","count":5}]},{"hash":"667072087318538778","title":"Unknown","description":"The top GO terms span diverse developmental and signaling processes (Rac/GTPase signaling, cell-cycle regulation, neural tube and skeletal development, lens differentiation, etc.) with no clear single function tying the proteins together, and there are no edges connecting them, so a cohesive, specific label isn\u2019t supported.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035021","count":3},{"id":"GO:0060197","count":3},{"id":"GO:0007050","count":3},{"id":"GO:0031666","count":3},{"id":"GO:0048485","count":3}]},{"hash":"1160518281576597870","title":"RNA processing and ribosome biogenesis","description":"The GO terms cluster around RNA processing and transcription across RNA polymerases I-III, spliceosome activity, snRNP assembly, mRNA export, RNA-templated transcription, and ribosome biogenesis, suggesting a coordinated module for RNA maturation and ribosome production rather than a single narrow function.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":2},{"id":"GO:0016973","count":2},{"id":"GO:0000387","count":1},{"id":"GO:0042797","count":1},{"id":"GO:0006360","count":1}]},{"hash":"979396569412919343","title":"Innate Immunity and Vascular Development","description":"The cluster\u2019s top GO terms point to innate immune processes (complement activation via lectin pathway, basophil activation, NK cell chemotaxis regulation) and vascular/lymphatic development (VEGF receptor signaling, lymph vessel morphogenesis). A developmental cartilage condensation term is present but less central, so the dominant theme is inflammation-related signaling tied to endothelial/lymphatic remodeling. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":7},{"id":"GO:0007171","count":4},{"id":"GO:0001502","count":4},{"id":"GO:0071226","count":4},{"id":"GO:0042730","count":4}]},{"hash":"1145877784024806866","title":"Neural Visual Signaling and Dopaminergic Reward","description":"The cluster shows strong representation of visual-related terms (visual perception, visual learning) and dopaminergic signaling with cocaine-related behavioral responses, pointing to neural visual processing and reward pathways. While heart development and angiogenesis appear among the terms, these may reflect pleiotropic roles or shared signaling pathways (ERK cascade, prostaglandin response) rather than a single function. ","confidence":"Medium","size":17,"edges":12,"triangles":3,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":11},{"id":"GO:0007507","count":11},{"id":"GO:0001525","count":10},{"id":"GO:0001963","count":10},{"id":"GO:0019233","count":10}]},{"hash":"1691267447356678566","title":"Embryonic Hematopoiesis and Lineage Differentiation","description":"Top terms show embryonic development with strong signals for hematopoietic lineage differentiation (erythrocyte, megakaryocyte, granulocyte) and primitive erythrocyte formation, alongside transcriptional regulation. This pattern suggests proteins involved in embryonic development and blood cell lineage specification, justifying a label focused on embryonic hematopoiesis and differentiation.","confidence":"High","size":17,"edges":4,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001701","count":9},{"id":"GO:0000122","count":7},{"id":"GO:0021983","count":7},{"id":"GO:0045654","count":6},{"id":"GO:0043046","count":6}]},{"hash":"1157011350046739749","title":"Hair follicle development and skin vascular remodeling","description":"The top GO terms point to skin/hair biology (keratinocyte differentiation and body hair orientation) and vascular processes (blood vessel remodeling, endothelial chemotaxis, vasoconstriction). Notch and Wnt signaling regulation are key in hair follicle morphogenesis, with GPCR signaling providing additional context for coordinated skin and vascular development. This suggests a cluster centered on hair/skin differentiation coupled with vascular remodeling.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0045746","count":6},{"id":"GO:0051965","count":5},{"id":"GO:0048105","count":5},{"id":"GO:0044332","count":5}]},{"hash":"1598756241532642523","title":"Notch-driven epithelial differentiation and palatal morphogenesis","description":"The cluster is dominated by Notch-related terms (Notch receptor processing and Notch signaling) along with keratinocyte differentiation and epithelial palatal morphogenesis, suggesting a cohesive role in epithelial development and morphogenesis. Additional terms on cell-matrix adhesion and migration align with remodeling during this process, while TNF-related signaling may reflect broader pathway crosstalk.","confidence":"High","size":17,"edges":20,"triangles":30,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007220","count":7},{"id":"GO:0030216","count":7},{"id":"GO:0034612","count":7},{"id":"GO:0007219","count":7},{"id":"GO:0010042","count":7}]},{"hash":"1161431572440418163","title":"DNA Replication and Cell Cycle","description":"The top terms are dominated by DNA replication, G1/S transition, and meiotic cell cycle, with kinetochore localization reinforcing a cell-division theme. Other terms (neuronal signaling, Schwann cell development, cartilage condensation) are more peripheral, so the core signal points to cell-cycle/DNA replication processes rather than a single cohesive function. Medium","confidence":"Medium","size":17,"edges":12,"triangles":5,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":8},{"id":"GO:0034501","count":7},{"id":"GO:0060079","count":7},{"id":"GO:0051321","count":7},{"id":"GO:0042220","count":7}]},{"hash":"290918435149757047","title":"Vertebrate development and cellular signaling","description":"The top GO terms point to vertebrate organ development (retina, coronary vessels) and fertilization, alongside core signaling and assembly processes (GTPase regulation, calcium release, protein heterotrimerization, cilium assembly, phagolysosome formation). This suggests a broad but cohesive theme of developmental programs intertwined with intracellular signaling and structural assembly.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":3},{"id":"GO:0007596","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0051209","count":2}]},{"hash":"551529958022267721","title":"Cell Cycle, Translation Initiation, and Proteolysis","description":"The terms cluster around cell proliferation and division (cell population proliferation, cell division, septum digestion after cytokinesis) together with translation initiation components (formation of translation preinitiation complex, translation reinitiation) and proteolysis (SCF-dependent ubiquitin-proteasomal degradation). The Arp2/3 actin nucleation regulation signals cytoskeletal remodeling during division, and the cellular hypoxia response suggests growth under stress. Overall, the cluster points to proliferative growth coordinated with translation initiation and protein turnover, rather than a single narrow function.","confidence":"Medium","size":17,"edges":16,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0002188","count":3},{"id":"GO:2000601","count":3},{"id":"GO:0001731","count":3}]},{"hash":"1289165708100636971","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":2},{"id":"GO:0042255","count":2},{"id":"GO:1902626","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0000472","count":2}]},{"hash":"955567424825723341","title":"Embryonic Development and Nervous System Formation","description":"The top GO terms span fertilization, skeletal development, myelination, calcium ion homeostasis, and locomotory behavior, along with male gonad and pituitary development, suggesting broad developmental programs across tissues with a notable emphasis on nervous system maturation (myelination, movement). While some terms like hyaluronan and chitin catabolic processes seem less cohesive, the overall theme centers on developmental regulation across organ systems, including neural components.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"lysosome organization","top_go_terms":[{"id":"GO:0007338","count":6},{"id":"GO:0001501","count":5},{"id":"GO:0042552","count":4},{"id":"GO:0006874","count":4},{"id":"GO:0030214","count":4}]},{"hash":"2303851275683355432","title":"Glycan and AGP biosynthesis","description":"The top GO terms point to synthesis and modification of glycans and glycoproteins, notably arabinogalactan proteins (AGPs) and related cell-surface polysaccharides (e.g., poly-N-acetyllactosamine, O-linked glycosylation via hydroxyproline, Lewis epitopes). Several terms pertain to plant extracellular matrix components and development (root hair formation, seed coat mucilage, cell adhesion/polarity), suggesting a common theme of extracellular glycan-based structures rather than a single intracellular pathway. Overall, the cluster appears to reflect glycosylation- and AGP-related biosynthesis of the cell surface/extracellular matrix across species.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030311","count":3},{"id":"GO:0042248","count":3},{"id":"GO:0007299","count":3},{"id":"GO:0018258","count":3},{"id":"GO:0080147","count":3}]},{"hash":"257040133055784402","title":"Membrane Transporters","description":"Based on the GO terms, the cluster centers on transport of diverse substrates across membranes\u2014xenobiotics, vitamins, selenite, sialic acid, urate, potassium ions, and neurotransmitter loading into synaptic vesicles. This coherent set of transmembrane transport processes suggests a group of membrane transporter proteins with broad substrate specificity or related transporter families, making \u201cMembrane Transporters\u201d an appropriate, representative label.","confidence":"High","size":17,"edges":95,"triangles":238,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":16},{"id":"GO:0035461","count":16},{"id":"GO:0097080","count":15},{"id":"GO:0015739","count":15},{"id":"GO:0052106","count":15}]},{"hash":"374189743877537032","title":"Broad Substrate Membrane Transporters","description":"This cluster is dominated by GO terms describing transmembrane transport across the plasma membrane for diverse substrates, from xenobiotics and vitamins to sialic acid, urate, fucose, and potassium ions. The presence of a term for neurotransmitter loading into synaptic vesicles supports vesicular transport as part of the theme. Altogether, the terms point to a cohesive function group of membrane transport proteins with broad substrate specificity rather than a single metabolic pathway.","confidence":"High","size":17,"edges":51,"triangles":59,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":17},{"id":"GO:0035461","count":17},{"id":"GO:0042891","count":16},{"id":"GO:0097080","count":14},{"id":"GO:0015739","count":14}]},{"hash":"85570376264686989","title":"RNA processing and translation regulation","description":"These proteins cluster around post-transcriptional control, with strong signals for spliceosome-mediated mRNA splicing regulation, translation initiation/reinitiation, and mRNA stability, indicating coordinated regulation of gene expression at splicing and translation steps.","confidence":"High","size":17,"edges":49,"triangles":86,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":9},{"id":"GO:0002188","count":9},{"id":"GO:0001731","count":9},{"id":"GO:0048026","count":9},{"id":"GO:1901407","count":9}]},{"hash":"900366010408492049","title":"Insulin Signaling and ER Stress Regulation","description":"GO terms cluster around insulin receptor signaling, regulation of unfolded protein response and PERK-mediated pathways, and dense core granule maturation, suggesting a theme of metabolic signaling linked to cellular stress and hormone secretion. Some terms (T cell signaling, endothelial barrier, dendritic spine regulation) appear less connected and may be peripheral.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":3},{"id":"GO:1902237","count":2},{"id":"GO:1903898","count":2},{"id":"GO:1903753","count":2},{"id":"GO:2001275","count":2}]},{"hash":"157694171144338843","title":"Telomere maintenance and telomerase regulation","description":"The cluster's top GO terms cluster around telomere biology: maintenance, capping, and localization to telomeric regions, plus regulation via telomerase and related ADP-ribosylation activities. There are also mitotic chromosome-related terms (spindle assembly, chromatid cohesion) that tie telomere maintenance to chromosome segregation, suggesting a cohesive telomere/chromosome stability theme. A few terms (e.g., Wnt) may be less directly connected or noisy, but the core signal is telomere-focused.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904743","count":3},{"id":"GO:0051225","count":3},{"id":"GO:0070213","count":3},{"id":"GO:1904355","count":3},{"id":"GO:0070198","count":3}]},{"hash":"1581300818888533154","title":"GPI-anchor and N-glycosylation biosynthesis","description":"The two strongest GO terms are GPI anchor biosynthetic process and dolichol-linked oligosaccharide biosynthetic process, pointing to protein glycosylation/maturation pathways. While other terms (pollen tube guidance, osmotic/volume responses, nitric oxide production) are present, they are less cohesive with glycosylation and likely secondary annotations; thus glycosylation-related biosynthesis best represents the core function of this cluster.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006506","count":2},{"id":"GO:0006488","count":2},{"id":"GO:0010183","count":2},{"id":"GO:0008156","count":2},{"id":"GO:0097640","count":1}]},{"hash":"280965865313340833","title":"Broad Developmental Signaling","description":"The terms repeatedly reference developmental processes (kidney development, angiogenesis, neuron projection and synaptic plasticity) and associated signaling pathways (T cell receptor signaling, PI3K signaling), with some cell-cycle related terms, suggesting a cluster of proteins involved in general development and intercellular signaling across tissues.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0031145","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0010976","count":2}]},{"hash":"575838758347759609","title":"ECM remodeling and EMT","description":"Top GO terms converge on extracellular matrix organization and assembly (elastic fiber, collagen fibril) and epithelial-to-mesenchymal transition, suggesting a shared role in ECM remodeling during development and tissue morphogenesis. Additional terms point to immune-related processes and processing events, which may reflect ECM-immune crosstalk or co-regulated pathways in developmental contexts. Overall, the cluster can be labeled ECM remodeling with EMT as a representative function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048251","count":3},{"id":"GO:2000483","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0001837","count":3},{"id":"GO:0021510","count":2}]},{"hash":"1634476664576876500","title":"Unknown","description":"The top GO terms are a mix of ubiquitin-related processes (ubiquitin-dependent protein catabolic process and negative regulation of protein ubiquitination) and disparate themes like circadian rhythm regulation, nervous system and muscle development, B cell signaling, and swimming. This heterogeneity provides no single cohesive function for the cluster, so a concise, representative label isn\u2019t discernible.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0050853","count":9},{"id":"GO:0042752","count":9},{"id":"GO:0042748","count":9},{"id":"GO:0007399","count":9}]},{"hash":"1329437736104452898","title":"Embryonic tissue development and morphogenesis","description":"These terms point to a range of tissue- and lineage-specific differentiation and morphogenesis events during embryonic development (melanocytes, pancreatic cells, oral roof, cartilage, hair follicles, mesoderm, placenta, left-right patterning). There isn\u2019t a single shared pathway; the common thread is broad developmental differentiation and morphogenesis across multiple tissues.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045636","count":2},{"id":"GO:0003323","count":1},{"id":"GO:0060021","count":1},{"id":"GO:0060536","count":1},{"id":"GO:0010957","count":1}]},{"hash":"507165894935683719","title":"Innate Immune Activation and Inflammation","description":"The top GO terms cluster around cytokine production (IL-6 and TNF), innate immune processes (basophil activation, NK cell chemotaxis regulation, lectin pathway complement activation) and responses to fungal origin, suggesting a coordinated innate immune/inflammatory program. A couple terms related to development or stress are present but do not override the core immune theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032755","count":2},{"id":"GO:0032760","count":2},{"id":"GO:0071480","count":2},{"id":"GO:0001502","count":2},{"id":"GO:2000502","count":2}]},{"hash":"1332908679442501046","title":"Sulfation and proteoglycan biosynthesis","description":"The top GO terms cluster around sulfation and glycosaminoglycan biosynthesis: protein sulfation, sulfate assimilation, and biosynthetic processes for heparan sulfate and chondroitin sulfate. This suggests a shared theme of sulfur-containing modifications and extracellular matrix (proteoglycan) assembly. Some auditory-related terms appear among the top terms, which may be noise or secondary associations rather than defining the cluster\u2019s core function. Overall, the dominant signal supports sulfation and proteoglycan biosynthesis as the main theme.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0071625","count":3},{"id":"GO:0006805","count":2},{"id":"GO:0030206","count":2},{"id":"GO:0015015","count":2}]},{"hash":"1482626735130506659","title":"Muscle metabolism and neuromuscular signaling","description":"The cluster\u2019s GO terms center on muscle function and neuromuscular pathways (musculoskeletal movement, neuromuscular process), calcium handling (release of sequestered Ca2+ into cytosol), energy and lipid metabolism, and endocrine responses (glucocorticoid, thyroid hormone), with supporting links to hypoxia response and mitochondrial involvement. This combination suggests a cohesive theme around muscle energy metabolism and signaling rather than unrelated functions.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070584","count":3},{"id":"GO:0031413","count":2},{"id":"GO:0019216","count":2},{"id":"GO:0050881","count":2},{"id":"GO:0050905","count":2}]},{"hash":"1957589420120776017","title":"Endosome-lysosome trafficking and autophagy","description":"The top GO terms cluster around endosome-to-lysosome transport, lysosome localization, and autophagosome maturation, along with general intracellular/vesicle transport. This points to a cohesive function in vesicle trafficking toward lysosomes and autophagic degradation, with a few developmental terms likely representing incidental associations. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008333","count":2},{"id":"GO:2001241","count":2},{"id":"GO:0021764","count":2},{"id":"GO:0097352","count":1},{"id":"GO:0050942","count":1}]},{"hash":"455230710989798452","title":"Mitotic spindle and microtubule dynamics","description":"The terms show a clear emphasis on mitosis and cytoskeletal functions, including mitotic cell cycle, mitotic spindle assembly, and microtubule-based movement, which strongly suggest a cluster centered on cell division and cytoskeleton dynamics. Additional terms related to ribosome biogenesis and protein interactions appear as supporting housekeeping roles, but do not override the dominant mitotic/cytoskeletal signal.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007338","count":4},{"id":"GO:0042254","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0000278","count":3}]},{"hash":"1948976854506452294","title":"Amino acid and cofactor biosynthesis","description":"This cluster is enriched for biosynthetic and metabolic processes, including biotin and protoporphyrinogen IX biosynthesis, beta-alanine and L-alanine metabolism, and antibiotic biosynthesis, suggesting a cohesive theme of amino acid and cofactor production; a Notch signaling term is present but far less representative.","confidence":"Medium","size":16,"edges":113,"triangles":468,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0019878","count":5},{"id":"GO:0009102","count":4},{"id":"GO:0006782","count":4},{"id":"GO:0017000","count":4}]},{"hash":"1267599689816621538","title":"Protein quality control and redox homeostasis","description":"The cluster centers on protein regulation and maintenance, highlighted by terms for redox homeostasis, ubiquitin-proteasome\u2013mediated nuclear quality control, post-translational targeting and trafficking, and regulation of kinase activity and protein export. While some terms are disparate, the strongest cohesive theme is maintaining protein function and cellular redox balance through controlled degradation, modification, and localization. Confidence: Medium","confidence":"","size":16,"edges":16,"triangles":6,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0090084","count":2},{"id":"GO:0071374","count":2},{"id":"GO:0000002","count":2}]},{"hash":"1062064472207930049","title":"Mitotic Cell Cycle Regulation","description":"The top GO terms point to control of the cell cycle, including positive regulation of CDK activity, G1/S and G2/M transitions, and cell division, with additional links to transcriptional regulation and stress-response pathways (ER UPR). This combination suggests a cluster centered on mitotic control and accompanying transcriptional regulation.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045737","count":7},{"id":"GO:0000082","count":6},{"id":"GO:0032026","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0006351","count":6}]},{"hash":"1250496216903057996","title":"Wnt and Rho GTPase Signaling","description":"The GO terms cluster around Wnt signaling (canonical and general) and positive regulation of GTPase activity, including Rho signaling, which together point to signaling cascades that control cytoskeletal dynamics and cell adhesion. Other terms (mRNA processing, interleukin-2 production, apoptotic process, heart-related signaling) are present but less central, suggesting broader regulatory roles rather than a single shared function. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:1900042","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0086098","count":2}]},{"hash":"90551327045303450","title":"Transcription and RNA modification","description":"The top GO terms are dominated by transcription-related processes (DNA-templated transcription, negative regulation of transcription by RNA polymerase II) and RNA modification (tRNA methylation, histone methylation). A couple of terms about Golgi transport and nodulation appear as outliers, suggesting some annotation noise or mixed functions, but the strongest signal across the cluster points to transcriptional regulation and RNA processing.","confidence":"Medium","size":16,"edges":7,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0030488","count":3},{"id":"GO:0009236","count":3},{"id":"GO:0090161","count":3},{"id":"GO:0006888","count":3}]},{"hash":"152401275242723010","title":"Steroid and lipid hormone metabolism","description":"The top GO terms center on hormone synthesis and signaling (prostaglandin biosynthesis; androgen metabolism; vitamin D response; retinoic acid catabolism; aldosterone-regulated blood volume; uterus development), suggesting a cohesive theme of endocrine hormone metabolism, with some ancillary detox-related terms present but not outweighing the hormone-focused signals.","confidence":"High","size":16,"edges":32,"triangles":25,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":14},{"id":"GO:0046232","count":12},{"id":"GO:0034653","count":11},{"id":"GO:0070989","count":11},{"id":"GO:0060065","count":11}]},{"hash":"1857792430658044179","title":"GPCR-Rho GTPase signaling in development","description":"This cluster centers on signaling pathways: GPCR signaling (acetylcholine receptor pathway), small GTPase and Rho-mediated transduction, and regulation of calcium-dependent exocytosis, together with developmental processes such as nervous system, heart, and skeletal development. The convergence of these terms suggests proteins coordinating developmental signaling and neurotransmission through GTPase and GPCR cascades, with supporting links to phosphatidylinositol biosynthesis.","confidence":"Medium","size":16,"edges":48,"triangles":73,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007399","count":7},{"id":"GO:0045956","count":7},{"id":"GO:0007124","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0001501","count":7}]},{"hash":"1071427513082491419","title":"Axon guidance and neural development","description":"The top GO terms center on axon extension and fasciculation, neuronal synaptic plasticity, and transcriptional control, all hallmarks of neural development and axon pathfinding. A few terms reference broader developmental morphogenesis and fertilization, but the dominant signal remains neural development and axon guidance.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007338","count":5},{"id":"GO:2000312","count":5},{"id":"GO:0048846","count":4},{"id":"GO:0060672","count":4},{"id":"GO:0007413","count":4}]},{"hash":"516519112793995198","title":"Immune activation and inflammatory cytokine production","description":"The top GO terms cluster around immune signaling and effector functions\u2014cytokine regulation (IL-23, IL-13), defense against viruses and fungi, granulocyte chemotaxis, immunoglobulin production, B cell apoptotic processes, and fibroblast activation with lamellipodium assembly\u2014reflecting coordinated innate and adaptive immune activation and inflammatory responses.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":2},{"id":"GO:0032747","count":2},{"id":"GO:0002230","count":2},{"id":"GO:2000667","count":2},{"id":"GO:0071621","count":2}]},{"hash":"1412331603753614948","title":"Embryonic Development and Neural Differentiation","description":"The GO terms point to broad developmental and differentiation processes across multiple tissues, especially neural lineages (subpallium neuron fate, spinal cord motor neuron fate, floor plate, amacrine cells) along with development of lung, bronchiole, pancreas, and bone; with transcriptional regulation (RNA polymerase II) and pathway regulation (androgen receptor signaling) suggesting coordinated developmental gene expression.","confidence":"Medium","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0060766","count":7},{"id":"GO:0045668","count":7},{"id":"GO:0060163","count":7},{"id":"GO:0060435","count":7}]},{"hash":"750875220913313529","title":"Unknown","description":"The GO terms are scattered across metabolism (polyamine biosynthesis and transport, arginine catabolism), cell cycle/mitosis (chromosome passenger complex localization to spindle midzone), structural organization (sarcomere, protein homooligomerization), organ development (kidney development), and Golgi/trafficking (trans-Golgi network organization). There\u2019s no single cohesive function that ties these terms together, so a specific, representative label cannot be confidently assigned.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0051260","count":3},{"id":"GO:0045214","count":3},{"id":"GO:0035853","count":3},{"id":"GO:0001822","count":2}]},{"hash":"1570175385054582440","title":"Developmental Transcriptional Regulators","description":"The top GO terms point to broad developmental programs across multiple organs (pituitary, retina, pancreas, inner ear, forebrain, spinal cord), with both positive and negative regulation of RNA polymerase II\u2013mediated transcription. This suggests a cluster of proteins that broadly regulate gene expression during organogenesis, particularly in neural and sensory tissue development.","confidence":"Medium","size":16,"edges":98,"triangles":302,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":9},{"id":"GO:0006366","count":6},{"id":"GO:0060041","count":6},{"id":"GO:2000288","count":6},{"id":"GO:0021986","count":6}]},{"hash":"2076940525220234931","title":"ECM adhesion and developmental signaling","description":"The terms point to extracellular matrix interactions and cell adhesion (integrin signaling, calcium-independent adhesion, collagen organization) coupled with developmental signaling pathways (Wnt and Notch regulation) and morphogenesis-related processes (embryo implantation, organ/tissue patterning). This suggests a cohesive theme of how cells engage the ECM to drive developmental signaling and tissue organization.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:2001027","count":7},{"id":"GO:0051965","count":7},{"id":"GO:0048105","count":7},{"id":"GO:0044332","count":6},{"id":"GO:0045746","count":6}]},{"hash":"1179720862466881420","title":"Plant defense signaling and lipid metabolism","description":"The top GO terms include systemic acquired resistance and salicylic acid\u2013mediated signaling, indicating a plant immune signaling role, alongside fatty acid homeostasis and sphingomyelin biosynthesis, pointing to lipid metabolism; together these suggest a cluster centered on coordinating metabolism with defense responses. ","confidence":"Medium","size":16,"edges":13,"triangles":5,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0009102","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0009862","count":2},{"id":"GO:0055089","count":2},{"id":"GO:0006351","count":2}]},{"hash":"2082773188332273586","title":"Nuclear transport and cell cycle regulation","description":"The top GO terms point to nuclear import (NLS-bearing proteins), mitotic nuclear envelope reassembly, DNA replication\u2013dependent chromatin assembly, and meiotic processes (meiotic spindle elongation and female meiotic nuclear division), along with chromatin regulation and broader cell-cycle\u2013related controls (desumoylation, Pol III transcription, GTPase regulation). A unifying theme is regulation of nuclear transport, chromatin dynamics, and division-related processes, with some ancillary links to ciliogenesis. Thus, a concise label is \u201cNuclear transport and cell cycle regulation.\u201d ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001241","count":4},{"id":"GO:0051232","count":4},{"id":"GO:0006607","count":3},{"id":"GO:0007084","count":3},{"id":"GO:0006335","count":3}]},{"hash":"1276072679815205331","title":"Secretory pathway and translation initiation","description":"The top GO terms cluster around secretory processes (pancreatic juice secretion; ER-to-Golgi transport), translation initiation and preinitiation complex formation, plus microtubule-based movement and development-related terms. This suggests a cohesive theme of intracellular protein handling, combining secretion/trafficking with translation initiation machinery, rather than unrelated functions. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030157","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0002188","count":2}]},{"hash":"499400227090788203","title":"Plasma membrane amino acid and small-molecule transport","description":"This cluster is driven by GO terms for importing amino acids (ornithine, methionine, leucine, arginine) and transmembrane transport of small molecules (D-serine, polyamines, carnitine), along with osmoregulatory processes (cell volume homeostasis, hypotonic salinity response). Together these suggest a membrane transport focus for amino acids and related metabolites, with supporting osmotic regulation signals.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097640","count":1},{"id":"GO:0044690","count":1},{"id":"GO:0098713","count":1},{"id":"GO:0071477","count":1},{"id":"GO:0002537","count":1}]},{"hash":"1258977897193677608","title":"Lectin-mediated innate immunity and leukocyte trafficking","description":"This cluster shows strong enrichment for innate immune processes: lectin receptor signaling, lectin pathway complement activation, basophil activation, NK cell chemotaxis regulation, and leukocyte tethering/rolling and adhesion, pointing to a cohesive immune recognition and leukocyte recruitment program. A couple of terms (cartilage condensation, senescence) are less central but do not override the dominant immune-theme signal.","confidence":"Medium","size":16,"edges":75,"triangles":158,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":14},{"id":"GO:0001867","count":14},{"id":"GO:0001502","count":12},{"id":"GO:2000502","count":12},{"id":"GO:0045575","count":12}]},{"hash":"22693098396932966","title":"Heart development and cardiac conduction","description":"The GO terms show a strong focus on heart development and electrical activity, including heart and pulmonary myocardium development, organ induction, SA node action potential, and regulation of atrial/ventricular membrane potentials and heart rate by conduction. The neuron migration and cranial skeleton morphogenesis terms likely reflect neural crest\u2013related contributions to heart development, suggesting a coherent cluster around cardiovascular development and its electrical function.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0001764","count":4},{"id":"GO:0048701","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0086015","count":3}]},{"hash":"1593963150970908585","title":"Endosomal sorting, exosome formation, and LDL uptake","description":"The dominant GO terms describe assembly and trafficking of intralumenal vesicles, regulation of exosomal secretion, and the multivesicular body sorting pathway, all key steps in endosome\u2013lysosome traffic and exosome biogenesis. Additional terms for vesicle-mediated transport and receptor-mediated endocytosis in cholesterol transport, including LDL particle clearance, reinforce a function in endosomal sorting and cholesterol uptake pathways. A few terms (e.g., sarcomere organization) may be noise and not central to the cluster\u2019s core function. Overall, the cluster points to proteins involved in endosomal vesicle formation and LDL receptor\u2013mediated uptake.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070676","count":2},{"id":"GO:1903543","count":2},{"id":"GO:0043162","count":2},{"id":"GO:0032091","count":2},{"id":"GO:0090611","count":2}]},{"hash":"1778906406910410113","title":"Neural development and myelination","description":"The terms cluster around neural tissue maturation: oligodendrocyte differentiation in the spinal cord, peripheral myelin maintenance, and broader neural development factors like Wnt signaling. Cytoskeletal dynamics (filopodium assembly, Rho signaling) and responses to prostaglandin also commonly appear in neural development contexts, supporting a theme of neural formation and myelination, though some terms point to general developmental processes (e.g., labyrinthine morphogenesis, palate development).","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071380","count":3},{"id":"GO:0060670","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0034446","count":3},{"id":"GO:0060022","count":3}]},{"hash":"1575525984734932367","title":"Unknown","description":"The GO terms are highly diverse, including histone modification, muscle calcium signaling, SMAD/ubiquitin processes, Hippo signaling, GTPase regulation, ergosterol biosynthesis, transcription, ribophagy, and mesoderm development, with no single prevailing function or pathway. The lack of connectivity (no edges) further suggests there isn\u2019t a cohesive biological theme linking these proteins.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097198","count":1},{"id":"GO:0014809","count":1},{"id":"GO:0030579","count":1},{"id":"GO:0035329","count":1},{"id":"GO:0043547","count":1}]},{"hash":"447518965523992056","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007283","count":2},{"id":"GO:0000732","count":1},{"id":"GO:0071048","count":1},{"id":"GO:0071039","count":1},{"id":"GO:0080188","count":1}]},{"hash":"827832215667874312","title":"Ephrin and integrin signaling with lamellipodium dynamics","description":"This cluster\u2019s GO terms cluster around signaling pathways (ephrin receptor signaling, integrin-mediated signaling, regulation of insulin receptor signaling) and cytoskeletal remodeling (lamellipodium assembly). The presence of heart development and long-term synaptic potentiation suggests broad developmental signaling roles, but the shared theme is extracellular signal transduction guiding actin dynamics and adhesion structures, which justifies this label.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048013","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0046626","count":3},{"id":"GO:0045671","count":3},{"id":"GO:0007507","count":3}]},{"hash":"618424824647461741","title":"Unknown","description":"The terms span stress responses, signaling, development, and RNA processing with no clear unifying function. Some GO terms are obsolete, and there is no consistent pathway tying all proteins together, so a specific label cannot be confidently assigned.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000249","count":2},{"id":"GO:0070301","count":2},{"id":"GO:1990314","count":2},{"id":"GO:0035066","count":2},{"id":"GO:0042552","count":2}]},{"hash":"1317329896113369954","title":"Cell cycle regulation and proteostasis","description":"The top GO terms cluster around progression through the cell cycle (G1/S transition, centrosome maintenance) and proteolytic control (proteasomal degradation, endopeptidase activity), suggesting a shared theme of cell-cycle control linked to protein turnover. Other terms point to signaling and cytoskeletal coordination, which can accompany division, while a few terms (antigen processing, tRNA splicing) appear peripheral and do not define the cluster. Overall, a cell-cycle/proteostasis theme fits best.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070493","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0051661","count":2},{"id":"GO:0061136","count":1},{"id":"GO:2000045","count":1}]},{"hash":"1380486372728404821","title":"Renal Filtration and Ion Transport","description":"The top GO terms are dominated by kidney-related processes: excretion, urea transport, intracellular water homeostasis, glomerular filtration, and potassium ion transmembrane transport, plus related intercellular transport concepts. While there are a couple outliers (lens development, ascospore formation), the prevalent theme points to renal function and ion/water balance. Confidence: Medium.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007588","count":3},{"id":"GO:0015840","count":3},{"id":"GO:0009992","count":3},{"id":"GO:1990349","count":3},{"id":"GO:0003094","count":3}]},{"hash":"638705845121292756","title":"Glycan biosynthesis and glycoprotein modification","description":"This cluster's top GO terms are dominated by glycosylation and arabinogalactan protein metabolism (poly-N-acetyllactosamine biosynthesis, O-linked glycosylation via hydroxyproline, arabinogalactan protein metabolism, Lewis a epitope biosynthesis). Additional terms relate to cell adhesion and epithelial polarity in follicle cells, as well as development-related processes like root hair and insect visual primordium formation. The unifying theme appears to be glycan biosynthesis and glycoprotein modification that shape cell surfaces and development across species.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":5},{"id":"GO:0030311","count":4},{"id":"GO:0042248","count":4},{"id":"GO:0007299","count":4},{"id":"GO:0018258","count":4}]},{"hash":"535944975221949420","title":"Rho/Rac GTPase\u2013driven cytoskeleton remodeling","description":"GO terms point to Rho and Rac GTPase signaling regulating actin dynamics (filopodium assembly) and cell migration, with connections to cardiac muscle contraction and heart development. This suggests a core theme of cytoskeletal remodeling controlled by Rho family GTPases affecting morphogenesis in heart and neural tissues. Some terms may reflect broader signaling roles rather than a single niche function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0007205","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0060048","count":3},{"id":"GO:0046847","count":3}]},{"hash":"2291988745199565568","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0039702","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0019068","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0030260","count":2}]},{"hash":"2236235574048177913","title":"Enteric neural signaling and gut motility","description":"The top terms point to the enteric nervous system and peristalsis (enteric nervous system development, peristalsis) with supporting signaling pathways (GPCR signaling, ERK and Rho cascades) and xenobiotic/metabolic context (response to xenobiotic stimulus, electron transport chain). This suggests a cohesive theme around neural control of gut motility and related signaling, though some metabolic terms add broader context. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042493","count":7},{"id":"GO:0045777","count":7},{"id":"GO:0048484","count":7},{"id":"GO:0022900","count":7},{"id":"GO:0010579","count":7}]},{"hash":"345512042709011334","title":"Mixed neural-immune signaling","description":"The top GO terms include clear neuronal synaptic activity (receptor clustering, excitatory postsynaptic potential, glutamatergic transmission, visual learning) but also several immune-related signals (dsRNA response, LPS signaling, interferon-beta production, GM-CSF response). With no observed interactions among proteins (Edges 0), the set spans both neural communication and immune response pathways, suggesting a loose, mixed functional theme rather than a single cohesive module.","confidence":"Low","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0043113","count":4},{"id":"GO:0097194","count":4},{"id":"GO:0060079","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0035249","count":3}]},{"hash":"700188094753565303","title":"Cell Cycle, Apoptosis, and Innate Immunity","description":"The top GO terms point to cell-cycle processes (DNA replication, mitotic spindle assembly) together with protein regulation (ubiquitination) and multiple stress-response pathways, including apoptotic and pyroptotic cell death and innate immune signaling, plus vesicle formation and oxidative stress response. This suggests a cluster of proteins involved in coordinating cell-cycle progression with stress-induced death and immune responses, rather than a single specific function.","confidence":"Medium","size":15,"edges":70,"triangles":147,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":8},{"id":"GO:0051260","count":8},{"id":"GO:1990001","count":7},{"id":"GO:0016567","count":7},{"id":"GO:0006915","count":7}]},{"hash":"1267876185872342129","title":"Neural development and pancreatic differentiation","description":"The cluster is dominated by GO terms related to neural development and neuron/fate specification (subpallium neuron fate, cerebral cortex GABAergic interneuron differentiation, spinal cord motor neuron fate, oligodendrocyte fate, midbrain development, and transcriptional regulation), with a notable but smaller subset tied to endocrine pancreas development. This pattern suggests proteins involved in neural cell fate decisions, with some involvement in pancreatic endocrine differentiation pathways, likely reflecting transcriptional regulation during development.","confidence":"High","size":15,"edges":53,"triangles":65,"max_degree":13,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":6},{"id":"GO:0031018","count":5},{"id":"GO:0060163","count":4},{"id":"GO:0060435","count":4},{"id":"GO:0021520","count":4}]},{"hash":"1756786416204567741","title":"Embryonic Organ Morphogenesis","description":"This cluster is enriched for embryonic development and organ morphogenesis terms across several tissues (eye, lung, placenta, heart, pituitary), indicating a cohesive role in embryogenesis and multi-organ morphogenesis rather than a single tissue function.","confidence":"High","size":15,"edges":33,"triangles":22,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0048048","count":7},{"id":"GO:0006366","count":7},{"id":"GO:0001701","count":6},{"id":"GO:0043010","count":6},{"id":"GO:0060441","count":6}]},{"hash":"2251485581902735338","title":"Mitochondrial translation and ribosome biogenesis","description":"The top GO terms cluster around protein synthesis machinery: general translation, regulation of translational fidelity, and ribosome biogenesis, complemented by multiple mitochondrial tRNA aminoacylation terms (seryl, threonyl, glycyl, methionyl) and mitochondrial translation-associated processes, plus related energy metabolism signals (TCA cycle). This supports a cohesive theme of mitochondrial protein synthesis and its regulation, with heart development possibly reflecting tissue-specific mitochondrial roles but not core to the cluster. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0006450","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0006099","count":2},{"id":"GO:0006431","count":2}]},{"hash":"2141770514506346203","title":"Cofactor and amino acid biosynthesis","description":"Most frequent GO terms cluster around biosynthetic pathways for key metabolites and cofactors: biotin, menaquinone, protoporphyrinogen IX (heme), and histidine; plus oxaloacetate metabolism linking to central carbon metabolism and redox-related processes. A few terms about antibiotic response and development appear as outliers. Overall, the cluster reflects metabolism-focused biosynthetic activities rather than signaling or transport.","confidence":"Medium","size":15,"edges":59,"triangles":94,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0000105","count":3},{"id":"GO:0006107","count":3},{"id":"GO:0009234","count":3},{"id":"GO:0009102","count":3}]},{"hash":"1539036192670465961","title":"Vertebrate Development and Organogenesis","description":"This cluster groups proteins linked to embryonic development and organ formation across multiple tissues, including neural crest, heart, visual system, uterus, gonads, and digestive tract, reflecting a common developmental program rather than a single pathway.","confidence":"High","size":15,"edges":33,"triangles":30,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0014029","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0060065","count":3}]},{"hash":"1246132493138972758","title":"Glycosaminoglycan Biosynthesis and Sulfation","description":"The proteins cluster around proteoglycan biosynthesis (heparan sulfate, chondroitin sulfate, heparin) and sulfation processes (protein sulfation; N-acetylglucosamine metabolism), suggesting a cohesive role in glycosaminoglycan assembly and modification. While terms like xenobiotic and catecholamine metabolism appear, the strongest and most frequent signals are glycosaminoglycan-related, supporting a focused theme on proteoglycan biosynthesis and sulfation.","confidence":"High","size":15,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006805","count":4},{"id":"GO:0030206","count":4},{"id":"GO:0015015","count":4},{"id":"GO:0006477","count":4},{"id":"GO:0006584","count":4}]},{"hash":"979107978765427675","title":"Membrane signaling and trafficking","description":"The cluster shows enrichment in membrane-associated signaling (integrin signaling regulation, Notch signaling) alongside ion transport and membrane potential terms (potassium/sodium transport, depolarization, excitatory postsynaptic potential), plus vesicle/trafficking processes (endosome-to-melanosome transport, vacuolar protein catabolic regulation) and junction assembly. This suggests a cohesive theme around membrane signaling and intracellular trafficking rather than a single, narrow function.","confidence":"Medium","size":15,"edges":14,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":9},{"id":"GO:0071805","count":5},{"id":"GO:0035725","count":5},{"id":"GO:0060079","count":5},{"id":"GO:0051899","count":5}]},{"hash":"1132723252672131963","title":"Transcription and Splicing in Cell Cycle Regulation","description":"The cluster shows strong enrichment for DNA-templated transcription, spliceosomal snRNP assembly, and the cell cycle, indicating coordinated control of gene expression and RNA processing during cell proliferation. Additional terms about transcription regulation and hormone levels further support a transcriptional regulation theme, though several obsolete GO terms are present.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0000387","count":2},{"id":"GO:0007049","count":2},{"id":"GO:1902455","count":1},{"id":"GO:0006355","count":1}]},{"hash":"1018929099938557295","title":"Neural signaling and vision","description":"The cluster\u2019s top GO terms strongly emphasize neural activity and sensory processing, including dopaminergic synaptic transmission, visual perception, retina development, and behaviors such as locomotion and fear response. While a few terms are more general (transcription, inflammatory response), the recurring theme centers on nervous system signaling and the visual system, suggesting a group of proteins involved in neural communication and eye-related development/function.","confidence":"Medium","size":15,"edges":7,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0007338","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0001963","count":2},{"id":"GO:0043252","count":2}]},{"hash":"220113472880151662","title":"Eye morphogenesis and neural-muscular development","description":"This cluster is dominated by eye development terms (camera-type eye development, embryonic eye morphogenesis) with strong support from neural and muscle development signals (cerebellum development, motor neuron axon guidance, skeletal and extraocular muscle development) and left/right patterning. The combination suggests a developmental program focusing on eye formation along with neural and muscular patterning, so the label reflects the core theme. ","confidence":"High","size":15,"edges":12,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0043010","count":8},{"id":"GO:0060441","count":8},{"id":"GO:0048048","count":8},{"id":"GO:0000122","count":6}]},{"hash":"107778071524882142","title":"Glycosylation and Notch signaling in neural-immune development","description":"The top GO terms point to neural development (neuronal stem cell maintenance; cerebral cortex migration), immune processes (leukocyte migration; regulatory T cell differentiation), and protein processing pathways (glycosylation, fucosylation, ER-to-Golgi transport) with Notch signaling modulation. This suggests a cluster of proteins involved in glycoprotein processing and trafficking that influence signaling pathways (Notch) shaping both neural development and immune cell behavior. The label aims to capture the central theme of glycosylation/trafficking intersecting with neural and immune development via Notch signaling.","confidence":"Medium","size":15,"edges":27,"triangles":6,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0097150","count":4},{"id":"GO:0010493","count":4},{"id":"GO:0006486","count":4},{"id":"GO:0002522","count":3},{"id":"GO:0036071","count":3}]},{"hash":"272614286430792235","title":"Spermatogenesis and Chromatin Regulation","description":"The cluster centers on male reproductive development (spermatogenesis, single fertilization, male gonad development) and transcription/chromatin control (negative regulation of RNA Pol II transcription, transcription preinitiation complex assembly, chromatin localization). This points to proteins coordinating germ cell development with chromatin remodeling and transcriptional regulation, with some additional regulatory roles hinted by plasminogen activation and Rho signaling.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0007338","count":5},{"id":"GO:0007283","count":5},{"id":"GO:0008584","count":5},{"id":"GO:0035023","count":5}]},{"hash":"1963398662229299375","title":"Actin Remodeling and Signaling","description":"Most GO terms point to actin cytoskeleton dynamics (actin filament branching, cytoskeleton reorganization, podosome assembly) and small GTPase\u2013mediated signaling, plus several receptor- and MAPK-related pathways (ephrin receptor signaling, Wnt canonical signaling, T cell receptor signaling, ERK cascade) and endocytosis. This suggests a module where cytoskeletal remodeling is coordinated with external receptor signals and endocytic processes. Therefore the label Actin Remodeling and Signaling captures the common theme.","confidence":"High","size":15,"edges":20,"triangles":1,"max_degree":6,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0043552","count":8},{"id":"GO:0090135","count":7},{"id":"GO:0090263","count":7},{"id":"GO:0048013","count":7},{"id":"GO:0007264","count":7}]},{"hash":"2136051094900600790","title":"Ribosome Biogenesis and Translation","description":"The cluster shows a clear enrichment for ribosome-related processes: translation, tRNA modification, ribosome biogenesis, and ribosomal subunit biogenesis/export terms, indicating a core function in assembling and maintaining the protein-synthesis machinery. Other terms like redox/homeostasis and stress response are present but less central to the main theme.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006400","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0042274","count":2}]},{"hash":"2108498671682279741","title":"Angiogenic signaling and endothelial adhesion","description":"These terms cluster around blood vessel formation and signaling: angiogenesis, positive regulation of angiogenesis, endothelial cell migration, cell-matrix adhesion, and MAPK/Wnt signaling cascades, consistent with a cohesive angiogenic signaling module.","confidence":"High","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":6},{"id":"GO:0045766","count":6},{"id":"GO:0007160","count":5},{"id":"GO:0014068","count":5},{"id":"GO:0070371","count":5}]},{"hash":"736775300416412712","title":"Nuclear-centric cell-cycle and ribosome biogenesis","description":"Most frequent GO terms point to nuclear functions: import of NLS-bearing proteins, chromatin assembly during DNA replication, mitotic nuclear membrane reassembly, and meiotic nuclear division, all suggesting core nuclear/cell-cycle processes. Additional terms for ribosome biogenesis and Pol III-driven transcription also occur in the nucleolus/nucleus, supporting a nucleolar theme. A few items (ciliary basal body docking) are peripheral but do not override the central nuclear-centric theme. Therefore, this cluster best represents nuclear/nucleolar processes linked to cell-cycle progression.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0061734","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0007084","count":2},{"id":"GO:0006335","count":2}]},{"hash":"937266704533702412","title":"Cell division and cytoskeletal dynamics","description":"This cluster is dominated by GO terms tied to cell division and cytoskeleton regulation: mitotic spindle assembly, microtubule polymerization dynamics, and actin filament depolymerization, which together point to coordinated cytoskeletal remodeling during cell division. Some development-related terms (lens fiber differentiation, neural tube closure, osteoblast differentiation) appear, suggesting broader developmental contexts, but the core signal remains cytoskeletal regulation during proliferation. A few other terms (RNA processing, ERAD) seem less connected, so the overall theme is moderate in cohesion.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0000447","count":2},{"id":"GO:1903461","count":2},{"id":"GO:0030042","count":2}]},{"hash":"2062688909035616397","title":"Cell signaling and proliferation regulators","description":"The top GO terms cluster around signaling pathways (VEGF receptor signaling, Hippo signaling, serine phosphorylation of STAT), together with processes tied to cell division (centriole replication, kinetochore localization) and proliferation (activated T cell proliferation) as well as vascular and immune-related responses. This suggests the proteins broadly regulate signaling and proliferative responses rather than a single specific function, supporting a label of cell signaling and proliferation regulators.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021537","count":2},{"id":"GO:0007099","count":2},{"id":"GO:0006349","count":2},{"id":"GO:0098586","count":1},{"id":"GO:0043536","count":1}]},{"hash":"877183005496742235","title":"Mitochondrial Transport and Fission","description":"The cluster is dominated by terms tied to mitochondria: mitochondrial membrane fission and ATP transmembrane transport, plus transport of cofactors like thiamine pyrophosphate and pyridoxal phosphate, with other membrane transport and mitochondrial maintenance terms. A few metabolic and signaling terms (insulin response, liver regeneration, fatty acid response) provide metabolic context, but the core theme is mitochondrial membrane transport and dynamics, especially fission. This makes \u201cMitochondrial Transport and Fission\u201d a concise and representative label.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":5},{"id":"GO:0030974","count":4},{"id":"GO:0032869","count":4},{"id":"GO:0000002","count":4},{"id":"GO:0036233","count":4}]},{"hash":"1192326244945323683","title":"Nervous system development and synapse assembly","description":"The cluster is enriched for nervous system development, neuron axon guidance, and synapse assembly, with supporting cadherin/integrin adhesion signals, pointing to neural differentiation and connectivity; some terms touch bone/nephron processes but neural themes predominate.","confidence":"High","size":15,"edges":26,"triangles":2,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0007157","count":4},{"id":"GO:0043931","count":4},{"id":"GO:0050973","count":3},{"id":"GO:1902354","count":3}]},{"hash":"912790866433997411","title":"Corpus callosum development and myelination","description":"The terms strongly point to CNS development, including corpus callosum formation, synapse assembly, and myelination, with signaling pathways like PI3K/AKT and hedgehog contributing to neural maturation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0043491","count":2},{"id":"GO:0060168","count":2}]},{"hash":"2274561690462429772","title":"Vascular morphogenesis and wound repair","description":"Many terms point to blood vessel formation and skin/tissue morphogenesis: angiogenesis, endothelial cell migration, skin development, and face morphogenesis. Wound healing and cellular response to mechanical stimulus further support a tissue remodeling program. Therefore, a label focusing on vascular morphogenesis and repair best captures the cluster.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0043536","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0060325","count":2},{"id":"GO:0001525","count":2}]},{"hash":"1257812220025229750","title":"Coagulation and extracellular matrix signaling","description":"This cluster centers on GO terms for plasminogen activation, fibrinolysis, platelet aggregation, integrin-mediated signaling, and cell-matrix adhesion, pointing to coagulation, clot remodeling, and cell-ECM communication. Angiogenesis and complement activation further reflect vascular remodeling and immune involvement, while a few terms (amelogenesis) appear less connected\u2014likely incidental. Overall, the dominant theme ties proteolysis, adhesion, and signaling in hemostasis and extracellular environment context.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031639","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0097186","count":2},{"id":"GO:0042730","count":2}]},{"hash":"1117746989121834545","title":"Acetylation-linked chromatin regulation","description":"This cluster is dominated by acetylation-related terms (peptidyl-lysine N6-acetylation; histone H4 acetylation; spermine acetylation) and chromatin-associated processes (subtelomeric heterochromatin formation; mitotic sister chromatid cohesion), suggesting a theme of chromatin modification via acetylation. Some outlier terms (mycothiol biosynthesis; angiogenesis) are present but do not disrupt the overall acetylation/chromatin focus.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018003","count":3},{"id":"GO:0010125","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0046208","count":2},{"id":"GO:0071962","count":2}]},{"hash":"1694738666112785866","title":"Unknown","description":"The terms are scattered across ubiquitin-dependent proteolysis, circadian regulation, immune signaling, nervous system development, and morphogenesis, with no clear, single theme tying the proteins together. Because the cluster combines diverse biological areas and lacks a cohesive function, a specific, representative label isn\u2019table; Unknown is the appropriate designation here.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0042752","count":12},{"id":"GO:0051260","count":11},{"id":"GO:0050853","count":10},{"id":"GO:0048294","count":10}]},{"hash":"28853037586286294","title":"Translation machinery and mRNA decay","description":"The dominant GO terms point to multiple steps of protein synthesis (initiation, elongation, termination) in both cytoplasmic and mitochondrial contexts, plus positive regulation of translation and a connected mRNA decay pathway (deadenylation-dependent decay). The antibiotic response term may reflect translational inhibition pathways, and the glial proliferation term could be a peripheral association. Overall, the cluster centers on translation and RNA turnover processes, with some ancillary connections. ","confidence":"High","size":14,"edges":60,"triangles":130,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0006413","count":5},{"id":"GO:0045901","count":4},{"id":"GO:0046677","count":4},{"id":"GO:0006415","count":4}]},{"hash":"435536096067560307","title":"Lectin-pathway complement activation and leukocyte recruitment","description":"The top terms center on lectin-activated complement (immune defense), C-type lectin receptor signaling, responses to fungi, leukocyte tethering/rolling, basophil activation, and NK cell chemotaxis, with supportive signals for lymphatic morphogenesis and cell adhesion, indicating an innate immune activation and immune cell recruitment theme. ","confidence":"High","size":14,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0001502","count":6},{"id":"GO:2000502","count":6},{"id":"GO:0071226","count":6},{"id":"GO:0045575","count":6}]},{"hash":"2219586359272459980","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000466","count":6},{"id":"GO:0042273","count":6},{"id":"GO:0000398","count":6},{"id":"GO:0007338","count":6},{"id":"GO:0000463","count":6}]},{"hash":"1619201883684100777","title":"Innate immune response with apoptosis and vesicle trafficking","description":"The terms include pyroptotic inflammatory response and innate immune response, plus apoptotic process and ubiquitination, with intralumenal vesicle formation and SNARE disassembly, pointing to a stress- and death-related immune pathway involving vesicle trafficking.","confidence":"Medium","size":14,"edges":21,"triangles":4,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070269","count":5},{"id":"GO:0090307","count":5},{"id":"GO:0016567","count":5},{"id":"GO:0045087","count":5},{"id":"GO:1990001","count":5}]},{"hash":"318657854144002341","title":"Developmental transcription and stress responses","description":"The terms point to transcriptional regulation (DNA-templated transcription) and developmental processes (multicellular development, neural tube closure) with notable stress/defense roles (ER stress\u2013related apoptosis, cadmium response, defense against Gram-positive bacteria). The cluster seems to center on gene regulation during development while also engaging cellular stress pathways, but the breadth of themes means there isn\u2019t a single tightly linked function. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0051260","count":7},{"id":"GO:0050830","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0001843","count":6}]},{"hash":"2236709330305332263","title":"One-carbon and methionine salvage metabolism","description":"This cluster centers on methionine cycling and one-carbon methylation processes, evidenced by L-methionine salvage, S-methylmethionine cycle, and RNA guanine-N7 methylation, plus cobalamin biosynthesis and pteridine metabolism. These suggest methyl-group transfer and one-carbon metabolism as core functions, with glycogen/glycolysis terms reflecting broader energy metabolism.","confidence":"Medium","size":14,"edges":15,"triangles":6,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":2},{"id":"GO:0009236","count":2},{"id":"GO:0042558","count":2},{"id":"GO:0042426","count":2},{"id":"GO:0006579","count":2}]},{"hash":"163496188806142001","title":"Developmental signaling and tissue patterning","description":"The proteins cluster around developmental processes across tissues (root development, neuron projection development, fungiform papilla formation) and regulatory signaling controls (negative regulation of proliferation and Wnt signaling, apoptosis), with supporting cellular activities like cell migration and mRNA/nuclear transport. This points to a theme of coordinating tissue development and patterning through signaling regulation, though some core cellular functions are also represented.","confidence":"Medium","size":14,"edges":19,"triangles":4,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":3},{"id":"GO:0090090","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0043065","count":3},{"id":"GO:0015991","count":3}]},{"hash":"346234891151483845","title":"Synaptic Vesicle Cycling and Calcium Signaling","description":"The cluster is dominated by GO terms related to synaptic activity and calcium handling: excitatory postsynaptic potential, calcium ion transmembrane transport, and regulation of synaptic vesicle exocytosis and endocytosis, indicating a core function in presynaptic vesicle cycling and postsynaptic excitability. Some development-associated terms (substantia nigra development, skeletal muscle fiber development) are present but appear ancillary to the main synaptic theme, possibly reflecting shared developmental programs rather than a primary function of these proteins.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":3},{"id":"GO:0070588","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0043388","count":2}]},{"hash":"49671065571614416","title":"Notch-regulated myoblast differentiation and mesoderm development","description":"This cluster is characterized by GO terms tied to developmental regulation in the mesoderm, especially Notch signaling modulation, myoblast differentiation, and mesodermal/vasculogenic differentiation, suggesting a coordinated role in muscle and vascular lineage specification rather than a single enzymatic function.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045746","count":5},{"id":"GO:0045663","count":4},{"id":"GO:0042264","count":4},{"id":"GO:0071318","count":3},{"id":"GO:0006351","count":3}]},{"hash":"2011598244284340453","title":"RNA Processing and Ribosome Biogenesis","description":"This cluster centers on RNA maturation and ribosome assembly: ncRNA-mediated gene silencing, splicing regulation, rRNA processing including snoRNA release, and mitochondrial large ribosomal subunit assembly, plus stress granule localization, indicating a cohesive module of RNA processing and ribosome biogenesis.","confidence":"High","size":14,"edges":78,"triangles":238,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":11},{"id":"GO:0048026","count":11},{"id":"GO:0000464","count":8},{"id":"GO:1903608","count":7},{"id":"GO:0006378","count":7}]},{"hash":"1258880121479076396","title":"Regulation of Signaling Pathways and UPR","description":"This cluster centers on proteins involved in dampening various signaling cascades (negative regulation of T cell receptor signaling, ERK/MAPK cascade, IL-6 signaling, IFN-\u03b1 production, and HGF receptor signaling) and components of the unfolded protein response (IRE1-mediated UPR), with some members also linked to adherens junction regulation. The common theme is modulation of cellular signaling and ER stress responses rather than a single pathway, justifying a general label of signaling regulation with links to ER stress.","confidence":"Medium","size":14,"edges":48,"triangles":75,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0050860","count":7},{"id":"GO:0070373","count":7},{"id":"GO:0000200","count":7},{"id":"GO:0070104","count":6},{"id":"GO:0035644","count":6}]},{"hash":"856557731687184260","title":"DNA Damage Response Regulators","description":"The top GO terms are centered on DNA damage sensing and repair and transcriptional regulation in response to DNA damage, including regulation of double-strand break repair via homologous recombination, replication-born DSB repair via sister chromatid exchange, and cellular response to gamma radiation. While several glycosylation/Development terms appear, the dominant theme across the cluster is DNA damage response and repair coordination, justifying a label focused on that function. ","confidence":"Medium","size":14,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1990414","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0010569","count":2},{"id":"GO:0071480","count":2},{"id":"GO:0030311","count":2}]},{"hash":"1629509136090340138","title":"Embryogenesis and Tissue Morphogenesis","description":"This cluster centers on broad developmental processes across multiple tissues (neural crest, trigeminal/ganglion, cerebellum, pancreas, digestive tract, ureteric bud) with supporting transcription regulation, suggesting a general embryonic morphogenesis theme rather than a single pathway; some terms may reflect incidental immune-related activity.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0007338","count":8},{"id":"GO:0000122","count":5},{"id":"GO:0061551","count":5},{"id":"GO:0048557","count":4},{"id":"GO:0031018","count":4}]},{"hash":"1898888134031415311","title":"SNARE-Mediated Synaptic Vesicle Exocytosis","description":"Based on the strong representation of GO terms related to vesicle trafficking between ER and Golgi, Golgi organization, SNARE complex assembly, synaptic vesicle docking, and exocytic insertion of neurotransmitter receptors, the proteins in this cluster appear to function together in SNARE-driven vesicle exocytosis at the synapse and related receptor trafficking, with links to synaptic plasticity such as LTP.","confidence":"High","size":14,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0043278","count":3},{"id":"GO:0048280","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0090161","count":3}]},{"hash":"1307987512668947794","title":"ECM remodeling and cell migration","description":"The dominant GO terms point to extracellular matrix dynamics and cell movement: hyaluronan metabolism, regulation of ECM assembly, metallopeptidase activity, and substrate-dependent cell migration, along with various adhesion and extravasation processes. These together suggest a cluster focused on remodeling the ECM to enable cells to adhere and migrate through tissues; germane immune-related term (T cell activation) may reflect immune cell trafficking, and blood coagulation ties in with matrix interactions during tissue remodeling. Overall, the central theme is ECM remodeling with associated adhesion and migration.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0030212","count":2},{"id":"GO:0002291","count":2},{"id":"GO:0007161","count":2},{"id":"GO:0031104","count":2}]},{"hash":"248929871734068520","title":"Endothelial sprouting angiogenesis and adhesion","description":"The top GO terms are centered on vascular development and endothelial interactions: endocardial cell differentiation, positive regulation of sprouting angiogenesis, cell-matrix adhesion, and heterophilic cell-cell adhesion, plus cell migration in angiogenesis, which together support a cohesive role in blood vessel formation and endothelial behavior. Some terms like complement activation and thyroid hormone generation are less directly tied but do not override the central vascular theme.","confidence":"Medium","size":14,"edges":4,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0006590","count":5},{"id":"GO:0007160","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0090050","count":5}]},{"hash":"1006557850955184496","title":"Membrane transport and vesicle loading proteins","description":"The cluster centers on several membrane transport processes\u2014potassium and sodium ion transmembrane transport, xenobiotic and sialic acid transport\u2014and includes a term for neurotransmitter loading into synaptic vesicles, pointing to a core theme of transport and vesicle function. A few terms like mismatch repair, protein folding, and placenta development are less directly related and may reflect annotation noise or multifunctional proteins. Overall, transport/vesicle-related activity dominates, justifying this label.","confidence":"Medium","size":14,"edges":27,"triangles":12,"max_degree":12,"top_function":"protein folding","top_go_terms":[{"id":"GO:0006298","count":3},{"id":"GO:0006457","count":3},{"id":"GO:0001890","count":3},{"id":"GO:0015739","count":3},{"id":"GO:0006004","count":3}]},{"hash":"74707794431307995","title":"Endocrine hormone and lipid mediator metabolism","description":"The top GO terms cluster around hormone- and vitamin-related metabolism and signaling: retinoic acid catabolic process, prostaglandin biosynthesis, androgen metabolic process, and response to vitamin D, plus regulation of aldosterone-related blood volume. This suggests the proteins share roles in endocrine signaling and lipid mediator (prostaglandin) metabolism, with some peripheral terms reflecting broader enzymatic activity or systemic regulatory effects. Confidence: Medium.","confidence":"","size":14,"edges":13,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0034653","count":6},{"id":"GO:0070989","count":6},{"id":"GO:0001516","count":6},{"id":"GO:0060065","count":6},{"id":"GO:0071280","count":6}]},{"hash":"32307941645576489","title":"Splicing and Translation Regulation","description":"The cluster centers on post-transcriptional control, with strong signals for mRNA splicing regulation via the spliceosome (both positive and negative), and multiple facets of translation initiation and reinitiation, including IRES-dependent viral initiation, plus regulatory ncRNA-mediated silencing. This suggests proteins involved in RNA processing and the control of translation, potentially including viral translation mechanisms.","confidence":"Medium","size":14,"edges":62,"triangles":141,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":12},{"id":"GO:0031047","count":11},{"id":"GO:0001731","count":11},{"id":"GO:0006378","count":10},{"id":"GO:0006446","count":10}]},{"hash":"60744140260423999","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071374","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0045199","count":2},{"id":"GO:0045198","count":2}]},{"hash":"2295000860935999909","title":"Nuclear Transport and Centrosome Regulation","description":"Proteins in this cluster are strongly tied to nuclear trafficking and cell-cycle related processes: localization to kinetochore, mRNA export from the nucleus, ribosomal subunit export, import of NLS-bearing proteins, and regulation of protein export from the nucleus. The inclusion of centrosome duplication regulation and transcriptional regulation by RNA Pol II further supports a theme of coordinating gene expression with cell-cycle control through nuclear transport and centrosome-related processes. Some peripheral terms ( xenobiotic response, phosphatidylcholine biosynthesis, desumoylation regulation) may reflect broader regulatory connections but do not dominate the signal.","confidence":"High","size":14,"edges":33,"triangles":30,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0034501","count":6},{"id":"GO:0006406","count":6},{"id":"GO:0000056","count":6},{"id":"GO:0000122","count":5},{"id":"GO:0006607","count":5}]},{"hash":"1333699984263203374","title":"Retinal neural signaling and plasticity","description":"This cluster centers on retina-related neural functions: visual perception, bipolar cell polarity, dopamine signaling in neurons, and synaptic plasticity, with supporting GPCR desensitization; together these terms point to retinal neuronal communication and adaptation, despite some immune-related terms present.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0061246","count":3},{"id":"GO:1903351","count":3},{"id":"GO:0018107","count":3},{"id":"GO:0007601","count":3}]},{"hash":"995405793674144977","title":"Ribosome biogenesis and translation machinery","description":"Based on the GO terms, the cluster centers on components and processes of ribosome assembly, translation, and tRNA processing (translation, cytoplasmic translation, ribosome biogenesis, ribosomal large subunit biogenesis, tRNA processing, etc.). The presence of cell cycle and conjugation terms may reflect coupling of growth/division with these core processes, but the dominant theme remains protein synthesis machinery.","confidence":"High","size":14,"edges":13,"triangles":2,"max_degree":11,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0007049","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0000747","count":3}]},{"hash":"297354259244066139","title":"Signaling and Membrane Potential Regulation","description":"This cluster centers on control of cellular signaling pathways (apoptotic regulation, NF-kappaB signaling) and membrane/ionic dynamics (regulation of membrane repolarization, potassium transporter activity, electrical coupling). Additional GO terms point to ER organization and proteoglycan biosynthesis, which tie into membrane protein processing and extracellular matrix production, and nucleotide-sugar turnover (UDP/GDP catabolic processes) that support biosynthetic activities. Together, they suggest a theme of coordinating signaling with membrane excitability and related biosynthesis. ","confidence":"Medium","size":14,"edges":13,"triangles":1,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:2001238","count":2},{"id":"GO:0046712","count":1},{"id":"GO:0030166","count":1},{"id":"GO:0060465","count":1},{"id":"GO:0006256","count":1}]},{"hash":"2079895905788676544","title":"Virus-host Interaction and Replication","description":"The terms point to viral life-cycle processes (virion assembly, proviral latency) and host exploitation (translation, lipid droplets, secretion) with related host responses (symbiont entry, leukocyte migration). This cohesive set suggests a cluster centered on virus\u2013host interactions and the replication cycle.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0030260","count":1},{"id":"GO:0050900","count":1},{"id":"GO:2000276","count":1},{"id":"GO:0019068","count":1}]},{"hash":"2124761635144948624","title":"Golgi-ER Vesicle Trafficking","description":"The cluster\u2019s top GO terms are dominated by vesicle transport between the Golgi and endoplasmic reticulum (retrograde and ER-to-Golgi) and clathrin-coated vesicle cargo loading, indicating a cohesive vesicular transport function. While there are meiosis- and cell-division\u2013related terms present, they are less representative of the overall theme, so the primary signal points to Golgi-ER trafficking machinery.","confidence":"Medium","size":14,"edges":16,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0006469","count":2},{"id":"GO:1903342","count":1},{"id":"GO:0007596","count":1}]},{"hash":"663521649955311583","title":"Innate Immune Recognition and Leukocyte Trafficking","description":"The top GO terms cluster around innate immunity and leukocyte movement: lectin pathway complement activation, stimulatory C-type lectin receptor signaling, response to fungal molecules, basophil activation, leukocyte tethering/rolling, and regulation of adhesion molecule production. A couple of developmental terms appear but immune-related terms dominate, supporting this label.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":14},{"id":"GO:2000502","count":14},{"id":"GO:0071226","count":14},{"id":"GO:0045575","count":14},{"id":"GO:0090403","count":14}]},{"hash":"1613439574367288611","title":"Arabinogalactan protein glycosylation and cell wall biosynthesis","description":"The top GO terms cluster around arabinogalactan protein (AGP) metabolism and related glycosylation processes (poly-N-acetyllactosamine biosynthesis, O-linked glycosylation via hydroxyproline, Lewis a epitope biosynthesis) along with plant developmental processes such as root hair cell development and seed coat mucilage biosynthesis. This points to a cohesive theme of plant cell-surface glycoproteins (AGPs) and their glycosylation pathways driving cell wall formation and related development. Some insect-related terms appear, but the dominant plant signals support the AGP/glycosylation theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030311","count":4},{"id":"GO:0042248","count":4},{"id":"GO:0007299","count":4},{"id":"GO:0018258","count":4},{"id":"GO:0080147","count":4}]},{"hash":"2073144030943712455","title":"Embryonic neural and organ development","description":"The terms cluster around neural development (rhombomere 4, medial motor column neuron differentiation, subpallium neuron fate commitment) and broad organogenesis (pituitary, retina, spleen, embryonic digit morphogenesis), suggesting proteins involved in early embryonic patterning and nervous system formation. A few items like platelet activation or redox are peripheral or outdated, but the core signal is embryonic development with a neural emphasis.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0021983","count":5},{"id":"GO:0030168","count":4},{"id":"GO:0021570","count":4},{"id":"GO:0048536","count":4}]},{"hash":"2044170774917844545","title":"Mitotic Chromosome Condensation and DNA Replication Factors","description":"The top GO terms are dominated by cell division, mitotic chromosome condensation, DNA replication, CENP-A containing chromatin assembly, and microtubule severing, which together point to a core mitotic and chromatin-maintenance module. Other terms (lens fiber cell differentiation, RNA splicing, ER-Golgi transport, and ubiquitin-dependent ERAD pathway) appear ancillary or reflect broader cellular roles or annotation noise, but do not override the central mitotic/chromatin theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0007076","count":3},{"id":"GO:0070306","count":3},{"id":"GO:0060213","count":3},{"id":"GO:0000398","count":3}]},{"hash":"2237054017654174986","title":"Neural Sensory Perception and Dopaminergic Signaling","description":"Most terms cluster around neural signaling: dopaminergic synaptic transmission, visual perception/learning, sensory perception of pain, and behavioral responses to cocaine; ERK cascade and prostaglandin response support signaling modulation. A few terms like heart development, macrophage chemotaxis, and electron transport chain may reflect broader cellular roles but do not define the cluster. Therefore this label highlights the central theme of neural sensory processing and dopamine-related signaling.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001963","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0010759","count":5},{"id":"GO:0048148","count":5}]},{"hash":"1633763039944372937","title":"Unknown","description":"The top GO terms are highly diverse and each appears only once, with no connecting edges or a shared pathway to unify the proteins; there is no coherent biological theme tying the cluster together.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":1},{"id":"GO:0051482","count":1},{"id":"GO:0071257","count":1},{"id":"GO:0050917","count":1},{"id":"GO:0022900","count":1}]},{"hash":"1015684580389726643","title":"Developmental Transcription Regulation and Differentiation","description":"This cluster centers on transcriptional control (regulation of DNA-templated transcription and RNA polymerase II transcription) and various developmental differentiation processes (angiogenesis, myotube differentiation, cartilage morphogenesis, placental/trophoblast development), with Rho signaling linked to cell morphology during differentiation. The viral process term is present but does not define the main theme; overall, the proteins seem tied to transcriptional regulation guiding developmental differentiation programs.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0035025","count":2},{"id":"GO:0010831","count":2}]},{"hash":"1866108280862188753","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000380","count":2},{"id":"GO:0000350","count":2},{"id":"GO:0000389","count":2},{"id":"GO:0051209","count":2},{"id":"GO:0002318","count":1}]},{"hash":"229349450489599651","title":"Endocytosis and intracellular trafficking","description":"The core terms\u2014receptor-mediated endocytosis, transferrin transport, vacuolar protein catabolism, and iron homeostasis\u2014suggest endocytic uptake and lysosomal degradation. Additional terms on ERAD glycoprotein trimming and membrane proteolysis point to intracellular quality control within trafficking pathways.","confidence":"Medium","size":14,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006898","count":1},{"id":"GO:1904382","count":1},{"id":"GO:0035609","count":1},{"id":"GO:0033572","count":1},{"id":"GO:0010103","count":1}]},{"hash":"1260873781164754145","title":"Neurodevelopment and Embryonic Morphogenesis","description":"The top GO terms point to embryonic development across neural, ocular, and skeletal tissues\u2014commissural neuron axon guidance, sympathetic ganglion development, optic fissure closure, and sclerotome development\u2014with EMT regulation also tying into morphogenesis. Additional terms reference general cellular responses (estrogen/xenobiotic) but do not override the developmental theme. Confidence: Medium","confidence":"","size":14,"edges":7,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071679","count":2},{"id":"GO:2000427","count":2},{"id":"GO:0061549","count":2},{"id":"GO:2000080","count":2},{"id":"GO:0071391","count":2}]},{"hash":"518267997910441539","title":"Unknown","description":"The Top Terms cover diverse processes (angiogenesis, spermatid development, SHH signaling, coagulation, metabolism, motor learning), with no dominant shared function among these proteins, so a cohesive, specific label isn\u2019t evident.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090051","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0007224","count":2},{"id":"GO:0045599","count":1},{"id":"GO:2000584","count":1}]},{"hash":"1087401824948023559","title":"Exocyst-mediated exocytosis and Golgi trafficking","description":"The cluster centers on exocytic vesicle trafficking from the Golgi to the plasma membrane, highlighted by GO terms for exocyst assembly and localization, vesicle tethering in exocytosis, and Golgi-to-plasma membrane transport. Together these terms indicate a cohesive function of exocyst components coordinating tethering and delivery of secretory vesicles from the Golgi. A few terms about intra-Golgi transport and Golgi organization support the Golgi-associated trafficking theme, making this an informative, specific cluster label.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015031","count":2},{"id":"GO:0008090","count":2},{"id":"GO:0090630","count":2},{"id":"GO:0006887","count":2},{"id":"GO:0090522","count":2}]},{"hash":"594469752545688142","title":"Immune signaling and B cell activation","description":"Dominant themes are immune signaling and lymphocyte activation: innate immune response, B cell receptor signaling, transitional B cell differentiation, T cell proliferation, and integrin-mediated signaling. Some isolated terms (heart development, deprecated regulations) are less central. Overall, the cluster appears to group proteins involved in immune signaling and B cell activation.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":4},{"id":"GO:0010863","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0043552","count":4}]},{"hash":"1297150376411837482","title":"Unknown","description":"The proteins show a highly diverse set of functions, from sphingolipid biosynthesis (globoside and MIPC) to mitochondrial processing and ATP synthase assembly, transcriptional regulation and nucleosome dynamics, DNA integration, and hypoxia response, with no observed interactions (Edges: 0, Triangles: 0, Max Degree: 0). This lack of a shared, cohesive function makes it inappropriate to assign a specific biological label.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036210","count":2},{"id":"GO:0001576","count":2},{"id":"GO:0051999","count":2},{"id":"GO:0031397","count":2},{"id":"GO:0015074","count":1}]},{"hash":"929635559392865891","title":"Angiogenesis and Endothelial Signaling","description":"This cluster is dominated by GO terms for angiogenesis, endothelial cell migration, and integrin/MAPK signaling (ERK cascade), pointing to a vascular development and signaling theme. Some neural-related terms appear, but they may reflect broader signaling or migratory processes shared with angiogenesis. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045766","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0046826","count":4},{"id":"GO:0043536","count":4}]},{"hash":"1421923244034646210","title":"Skeletal muscle differentiation and development","description":"This cluster is enriched for GO terms related to skeletal muscle cell differentiation and skeletal muscle tissue development, indicating a muscle-formation theme. While other terms like nervous system development, circadian rhythm, and B cell signaling appear among the top terms, the strongest signals center on muscle formation, suggesting the proteins collectively participate in muscle development with some multifunctionality or annotation noise.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":5},{"id":"GO:0050853","count":4},{"id":"GO:0042748","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0031397","count":4}]},{"hash":"2027117843072131968","title":"Vesicle trafficking and ubiquitin-mediated protein turnover","description":"The top terms point to intracellular transport and vesicle dynamics\u2014exocytosis, vesicle docking, vesicle tethering, and Golgi-related to plasma membrane transport, plus endosome-to-Golgi traffic. The ubiquitin-dependent protein catabolic process aligns with protein turnover often coupled to trafficking. While some terms touch on unrelated signaling (cytokinin, B cell receptor) and lipid homeostasis, the strongest cohesive theme is endomembrane trafficking complemented by protein degradation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0070328","count":2},{"id":"GO:0009736","count":2},{"id":"GO:0045907","count":2},{"id":"GO:0006887","count":1}]},{"hash":"1156543935823800821","title":"Neuroimmune Development and Signaling","description":"This cluster centers on Toll-like receptor signaling (TLR3/7/9) and immune regulation (IL-2 production, T cell activation suppression), with additional neural/developmental themes such as myelination, bone development, and axis specification. The combination suggests proteins involved in immune sensing that also participate in developmental or neural processes, rather than a single, narrowly defined function. Confidence: Medium","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":3},{"id":"GO:0034162","count":3},{"id":"GO:0034154","count":3},{"id":"GO:0060168","count":3},{"id":"GO:0060348","count":3}]},{"hash":"813955242177889338","title":"Central carbon metabolism and lipid metabolism","description":"The Top Terms reveal a strong emphasis on core energy and carbon-flow processes: glycolysis, the TCA cycle, 2-oxoglutarate metabolism, and amino acid catabolism (alanine, kynurenine), along with lipid metabolism (fatty acid biosynthesis, malonyl-CoA biosynthesis, beta-oxidation). This points to a cluster of proteins involved in energy production and carbon flux, with Notch signaling appearing less central. Confidence reflects that metabolic theme is clear, though some signaling terms introduce noise.","confidence":"Medium","size":13,"edges":72,"triangles":231,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":3},{"id":"GO:0007219","count":3},{"id":"GO:0042853","count":3},{"id":"GO:0097053","count":3},{"id":"GO:0006096","count":3}]},{"hash":"697075566043036815","title":"Unknown","description":"The GO terms are a mix of replication-related processes (DNA replication, DNA recombination), immune/stress responses (response to lipopolysaccharide), translation, protein oligomerization, Golgi retention, and folate metabolism, with several obsolete terms. There isn\u2019t a single cohesive biological function or pathway that unites these 13 proteins, so a specific, representative label cannot be determined confidently.","confidence":"","size":13,"edges":51,"triangles":100,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0019079","count":3},{"id":"GO:0032496","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1155291818536870074","title":"Unknown","description":"The top GO terms are highly diverse, spanning neuronal signaling (excitatory postsynaptic potential), DNA replication/recombination, stress response, symbiont dormancy, and lipid signaling (DAG, sphingosine, lipid phosphorylation), plus GPCR signaling and angiogenesis. This lack of a single unifying function suggests no coherent theme for a concise label.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0085014","count":2},{"id":"GO:0006950","count":2},{"id":"GO:0006310","count":2}]},{"hash":"21817871179703044","title":"Actin Cytoskeleton Remodeling and Adhesion Signaling","description":"The cluster centers on actin dynamics\u2014filopodium and podosome assembly, actin polymerization and branching\u2014driven by small GTPases and linked to cell adhesion and signaling pathways (ephrin, T cell receptor, Wnt), indicating coordinated cytoskeletal remodeling and cell movement.","confidence":"High","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046847","count":8},{"id":"GO:0007264","count":8},{"id":"GO:1900026","count":8},{"id":"GO:0048013","count":7},{"id":"GO:0090135","count":7}]},{"hash":"1275632951798437555","title":"Developmental transcription and morphogenesis","description":"Most top GO terms center on development and transcription regulation (mitotic cell cycle, multicellular organism development, DNA-templated transcription, neural tube closure, skin development) with supporting processes such as mRNA transport and GTPase activity regulation, suggesting a coherent developmental/morphogenetic program rather than a single specialized pathway. A few terms relate to hypoxia and immune defense, but they appear secondary to the dominant developmental theme. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0071456","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0043588","count":2}]},{"hash":"1465051999260291277","title":"Redox Homeostasis and Oxidative Stress Response","description":"This cluster centers on redox regulation and defense against oxidative damage: detoxification of oxidants, maintaining redox balance, and responses to oxidative stress, with supporting DNA repair (nucleotide-excision) and deglutathionylation. A UV-protection term aligns with repair of UV-induced damage; one outlier term is incidental.","confidence":"High","size":13,"edges":28,"triangles":37,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":5},{"id":"GO:0045454","count":4},{"id":"GO:0009650","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006289","count":2}]},{"hash":"1787953993866866431","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071042","count":2},{"id":"GO:0071035","count":2},{"id":"GO:0000184","count":2},{"id":"GO:0071038","count":2},{"id":"GO:0071051","count":2}]},{"hash":"1548610023301364981","title":"Cardiac calcium signaling and excitation","description":"The top GO terms cluster around calcium release into the cytosol, regulation of cAMP/adenylate cyclase signaling, protein phosphorylation, and heart-related processes (SA node action potential, heart development), which together point to cardiac excitation-contraction signaling and calcium handling. Some unrelated terms (e.g., visual perception) and obsolete entries appear but do not alter the main cardiac theme.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":4},{"id":"GO:0051209","count":3},{"id":"GO:0098907","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0006468","count":3}]},{"hash":"44430495714922825","title":"Blood coagulation and fibrinolysis","description":"Most of the top terms converge on blood coagulation and fibrinolysis (plasminogen activation, fibrinogen regulation, activation of coagulation factors including XII, and promotion of fibrinolysis), indicating a cohesive hemostasis module. A developmental term (rhombomere boundary formation) appears peripherally, and an inflammatory response term (response to LPS) may reflect coagulation\u2013inflammation cross-talk.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031639","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0044537","count":4},{"id":"GO:0051919","count":4},{"id":"GO:0014909","count":4}]},{"hash":"1876583695098916519","title":"Spliceosome-mediated RNA processing and regulation","description":"This cluster centers on mRNA splicing via the spliceosome (positive/negative regulation, cis splicing), plus related post-transcriptional processes such as mRNA export, stabilization, and regulation of translational initiation, along with regulatory ncRNA-mediated gene silencing. Together these terms point to a cohesive theme of RNA processing and post-transcriptional control of gene expression.","confidence":"High","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":6},{"id":"GO:0048026","count":6},{"id":"GO:0045292","count":6},{"id":"GO:0048025","count":5},{"id":"GO:1902625","count":5}]},{"hash":"2123054836310516868","title":"RNA Splicing and Post-transcriptional Regulation","description":"Top GO terms indicate strong involvement in mRNA splicing via the spliceosome, regulation of splicing (both positive and negative), mRNA stability, export from the nucleus, and regulation of translational initiation, along with regulatory ncRNA\u2013mediated gene silencing. This combination points to a cohesive cluster focused on post-transcriptional RNA processing and fate decisions (splicing, stability, export, and translation control). Therefore the label reflects the central theme of RNA maturation and regulation.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":9},{"id":"GO:0048026","count":9},{"id":"GO:0010610","count":9},{"id":"GO:0000398","count":7},{"id":"GO:0048025","count":6}]},{"hash":"352512639498811568","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":10,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007219","count":3},{"id":"GO:0042853","count":3},{"id":"GO:0097053","count":3},{"id":"GO:0032543","count":2},{"id":"GO:0019442","count":2}]},{"hash":"2212129684068822410","title":"Phosphorylation-driven developmental and stress signaling","description":"The cluster centers on protein phosphorylation and related regulatory processes (e.g., cell cycle controls, apoptotic regulation) that span development, stress responses (hypoxia, ABA signaling), and signaling in neural contexts (visual perception, excitatory synaptic activity). This suggests a cohesive theme of phosphorylation-mediated signal transduction coordinating growth, fate decisions, and adaptation across tissues.","confidence":"Medium","size":13,"edges":50,"triangles":96,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043065","count":8},{"id":"GO:0007275","count":8},{"id":"GO:0071456","count":6},{"id":"GO:0009738","count":6},{"id":"GO:0060079","count":6}]},{"hash":"851810095963401457","title":"Innate and Adaptive Immune Signaling","description":"The top GO terms strongly point to immune signaling, with innate recognition via C-type lectin receptors and responses to fungal origin, plus adaptive signaling through T cell receptors and basophil/NK-related activities. While there are some development- or proliferation-related terms (DNA replication, cartilage condensation, dendrite morphogenesis), the dominant theme centers on immune receptor signaling and activation, justifying an immune-focused label.","confidence":"Medium","size":13,"edges":7,"triangles":0,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0002223","count":5},{"id":"GO:0006260","count":3},{"id":"GO:0050774","count":3},{"id":"GO:0043488","count":3},{"id":"GO:0090263","count":3}]},{"hash":"1927993687533926557","title":"Mitotic Cell Cycle Regulation and Proliferation","description":"The top GO terms indicate mitotic transitions (G1/S and G2/M), spindle pole separation, and re-entry into mitosis, alongside transcriptional activity and chromosome condensation. Additional signals related to growth and proliferation (hippo signaling, insulin signaling, mammary epithelial proliferation) support a cohesive theme of cell cycle control coupled with proliferative signaling.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000086","count":6},{"id":"GO:0010696","count":6},{"id":"GO:0000320","count":6},{"id":"GO:0000082","count":6},{"id":"GO:0046626","count":6}]},{"hash":"625731785701102891","title":"Lectin-pathway Innate Immunity Activation","description":"The set of terms centers on innate immune recognition and response via lectin receptors and the complement system (complement activation, lectin pathway; stimulatory C-type lectin receptor signaling), with related leukocyte adhesion/rolling and basophil activation, plus fungus-origin response. This points to a cohesive module of innate immune activation and leukocyte trafficking driven by lectin- and complement-mediated signaling, rather than a metabolic or developmental process. ","confidence":"High","size":13,"edges":39,"triangles":32,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":10},{"id":"GO:0071226","count":9},{"id":"GO:0010572","count":7},{"id":"GO:0001502","count":6},{"id":"GO:2000502","count":6}]},{"hash":"2138241007137020831","title":"Neural development and axon guidance","description":"This cluster is enriched for nervous system development, neuron migration (SVZ to olfactory bulb), axon guidance (Roundabout signaling), and cochlea morphogenesis, pointing to roles in neural patterning and wiring; while a few terms are less central (nucleolus localization, mast cell chemotaxis), the dominant theme is neural development and guidance signaling.","confidence":"High","size":13,"edges":34,"triangles":29,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:1902570","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0022028","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0043524","count":2}]},{"hash":"2162692036746436517","title":"Oxidative Stress Response and DNA Repair","description":"The terms cluster around cellular oxidant detoxification, redox homeostasis, glutathione metabolism, and protein glutathionylation, with supporting links to nucleotide-excision repair and stress response, indicating a redox-centered defense and maintenance program.","confidence":"High","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":9},{"id":"GO:0045454","count":8},{"id":"GO:0006289","count":7},{"id":"GO:0006749","count":7},{"id":"GO:0010731","count":7}]},{"hash":"1456665997792494800","title":"Endocytic trafficking and cytoskeleton remodeling","description":"These proteins appear to function together in endocytosis and endosome-associated receptor trafficking (endocytosis; protein localization to endosome; neurotransmitter receptor transport from endosome to postsynaptic membrane) while also underpinning cytoskeleton rearrangements and cell polarity (mitotic spindle assembly; actin cytoskeleton reorganization; establishment/maintenance of cell polarity; cell spreading). This points to a module coordinating vesicle trafficking with cytoskeletal dynamics and cell movement. ","confidence":"Medium","size":13,"edges":34,"triangles":32,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090307","count":4},{"id":"GO:0031532","count":4},{"id":"GO:0033144","count":4},{"id":"GO:0071963","count":4},{"id":"GO:1900026","count":4}]},{"hash":"630817347301616928","title":"Multitissue differentiation and signaling","description":"The terms point to differentiation and development across several tissues (keratinocyte differentiation, hair cycle, brown fat differentiation) with supporting notes on tissue remodeling and signaling (Notch processing, smooth muscle and endothelial dynamics). This suggests a broad theme of differentiation and remodeling rather than a single, cohesive pathway, hence a label reflecting multicellular differentiation across tissues. ","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0021693","count":4},{"id":"GO:0061419","count":4},{"id":"GO:1903588","count":4},{"id":"GO:0090336","count":4}]},{"hash":"1973177552683206961","title":"Multitissue differentiation and Notch signaling","description":"This cluster appears to group proteins involved in developmental differentiation across multiple tissues. The top terms point to lung development, keratinocyte differentiation, the hair cycle, brown fat differentiation, and brain (Purkinje cell layer) organization, with Notch receptor processing indicating a signaling control mechanism. Although a couple GO terms are obsolete, the shared theme is tissue morphogenesis and differentiation coordinated by signaling.","confidence":"Medium","size":13,"edges":8,"triangles":1,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":12},{"id":"GO:0030324","count":7},{"id":"GO:0021693","count":6},{"id":"GO:0061419","count":6},{"id":"GO:1903588","count":6}]},{"hash":"2226978358740710340","title":"Gene expression and ribosome biogenesis","description":"The top GO terms span transcription, RNA processing (splicing and export), translation, and ribosome biogenesis, pointing to proteins involved in the full gene-expression pipeline from transcription through translation and ribosome assembly, rather than a single narrow function.","confidence":"Medium","size":13,"edges":59,"triangles":154,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006406","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0031564","count":2},{"id":"GO:0051301","count":2}]},{"hash":"242019172092249490","title":"Immune and neural signaling regulators","description":"This cluster centers on immune-related signaling (IL-2 production; T cell polarity) and dopaminergic neural signaling (synaptic transmission), with a common thread of PKC signaling. Additional terms on lipid localization, cholesterol biosynthesis regulation, and extracellular matrix disassembly point to broader roles in cell signaling, trafficking, and remodeling that span immune and nervous system contexts. Confidence: Medium","confidence":"","size":13,"edges":45,"triangles":72,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0022617","count":3},{"id":"GO:0007588","count":3},{"id":"GO:0070528","count":3},{"id":"GO:0010876","count":3},{"id":"GO:0070584","count":3}]},{"hash":"295792927305065119","title":"GPCR Signaling with Metabolic and Immune Modulation","description":"The top GO terms center on GPCR-mediated signaling and adenylate cyclase activation, which points to receptor-driven communication. Immune-related terms like interleukin-12 production and TNF regulation suggest coordinated immune modulation. Other terms indicate systemic responses to stimuli (temperature, xenobiotics, feeding behavior, reproduction) that often involve neuroendocrine signaling and metabolic status, which can be linked to GPCR pathways and cellular energy use. The electron transport chain term likely reflects core metabolic state that accompanies signaling and immune activity. Taken together, the cluster seems to capture signaling responses integrating metabolism, immunity, and environmental cues.","confidence":"Medium","size":13,"edges":15,"triangles":3,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":10},{"id":"GO:0045777","count":10},{"id":"GO:0010579","count":10},{"id":"GO:0007190","count":9},{"id":"GO:0032720","count":7}]},{"hash":"2076556646458414406","title":"Cell Proliferation and Differentiation Signaling","description":"This cluster is enriched for terms tied to signaling pathways that regulate cell growth, differentiation, and fate decisions (Hippo signaling, Wnt signaling, keratinocyte differentiation, DNA replication, apoptosis) as well as immune activation (T cell receptor signaling, activated T cell proliferation). While there are tissue-specific terms (keratinocytes, potassium transport) the common thread is signaling networks that control proliferation and differentiation across cell types, including immune cells. ","confidence":"Medium","size":13,"edges":5,"triangles":1,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035329","count":10},{"id":"GO:0030216","count":10},{"id":"GO:0060044","count":10},{"id":"GO:0006813","count":10},{"id":"GO:0090263","count":10}]},{"hash":"1361273389093319902","title":"Th2 Cytokine Regulation and Immune Signaling","description":"The top GO terms point to modulation of Th2-type immune responses and cytokine production (positive regulation of IL-10, Th2 differentiation and Th2 cytokine production), along with integrin signaling and regulation of immune-related processes such as chemokine production and glial cell survival. While a coagulation term appears, the overall signal centers on immune regulation and signaling rather than a single catabolic or metabolic pathway, justifying a Th2-focused immune label.","confidence":"High","size":13,"edges":33,"triangles":23,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0007229","count":2},{"id":"GO:2000769","count":2},{"id":"GO:2001181","count":2},{"id":"GO:2000342","count":2}]},{"hash":"700901483554226943","title":"Mitochondrial energy metabolism and redox homeostasis","description":"This cluster contains GO terms centered on central energy production\u2014glycolysis, 2-oxoglutarate metabolism, and mitochondrial electron transport\u2014along with redox-related processes like removal of superoxide radicals and redox homeostasis. Lipoate metabolism further ties to key dehydrogenase complexes essential for energy conversion. A couple of terms such as sperm capacitation and alkane catabolic process appear as outliers, but the dominant signal reflects mitochondrial energy production and redox maintenance.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0006103","count":2},{"id":"GO:0006096","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0043448","count":2}]},{"hash":"294392779771681813","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0017000","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0009113","count":2},{"id":"GO:0006541","count":2}]},{"hash":"1160654324529470539","title":"SCF-ubiquitin-regulated mitosis and DNA repair","description":"Labels dominated by SCF-dependent ubiquitin-proteasome degradation, G2/M transition, mitosis exit, chromosome segregation, and nucleotide-excision repair point to ubiquitin-mediated cell-cycle control and genome maintenance. The other terms suggest broader stress signaling that can intersect with ubiquitin pathways. The cluster thus represents proteins coordinating mitotic progression with DNA repair and proteostasis.","confidence":"High","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0031146","count":13},{"id":"GO:0000086","count":13},{"id":"GO:0016032","count":13},{"id":"GO:0007059","count":13},{"id":"GO:0070911","count":13}]},{"hash":"1617162893661351199","title":"Sperm-Zona Pellucida Binding and Acrosome Activation","description":"Based on the enrichment of fertilization-related GO terms, especially binding of sperm to zona pellucida, penetration of the zona pellucida, and regulation of the acrosome reaction, the cluster likely comprises proteins involved in sperm-egg recognition and acrosome activation. Glycosphingolipid biosynthesis and glycosylation terms may reflect membrane glycoproteins important for these interactions; some mammary gland development terms are less central but do not override the core reproductive theme.","confidence":"High","size":13,"edges":19,"triangles":7,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0030879","count":3},{"id":"GO:0006688","count":2},{"id":"GO:0060054","count":2},{"id":"GO:0045136","count":2}]},{"hash":"830987751146889591","title":"Lectin-mediated innate immunity and leukocyte recruitment","description":"The top GO terms point to innate immune sensing and leukocyte trafficking: lectin-pathway complement activation, stimulatory C-type lectin receptor signaling, leukocyte tethering/rolling, and regulation of adhesion molecule production. Basophil activation and responses to fungal origin further support a machine-focused theme of lectin-driven immune recognition and recruitment. Some terms (cartilage condensation, lymph vessel morphogenesis) are less directly tied but can relate to inflammatory or developmental contexts that intersect with immune signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":7},{"id":"GO:0071226","count":7},{"id":"GO:2000502","count":6},{"id":"GO:0045575","count":6},{"id":"GO:0090403","count":6}]},{"hash":"683317502638642202","title":"Meiosis and Spermatogenesis","description":"The terms strongly point to germ cell development with meiotic processes: spermatid development, sperm DNA condensation, lateral element assembly, and female meiosis chromosome separation, plus a general cell-cycle context; some transcription-related terms likely reflect gene regulation during these processes. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":1},{"id":"GO:0090156","count":1},{"id":"GO:1900118","count":1},{"id":"GO:0051309","count":1},{"id":"GO:0051878","count":1}]},{"hash":"1073884806407970182","title":"Cardiovascular and Immune Signaling","description":"The terms cluster around signaling processes related to cardiovascular development (heart and blood vessel development, vascular smooth muscle regulation) and immune communication (immunological synapse formation, IL-2 production, GPCR signaling). Additional terms point to general signal transduction (GTPase activity, lipid phosphorylation). Some items appear less connected (vocalization behavior, potassium export), but the common theme of signaling in cardiovascular and immune contexts fits best. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0071625","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0001568","count":3},{"id":"GO:0007205","count":2}]},{"hash":"1467440351223416115","title":"Steroid and lipid hormone metabolism","description":"This cluster\u2019sGO terms center around metabolism and signaling of lipid-derived hormones and related compounds\u2014retinoic acid, androgens, prostaglandins, vitamin D\u2014as well as regulatory endocrine processes (e.g., aldosterone-related blood volume, uterus development). The recurring themes are enzymatic oxidation/demethylation steps and hormone-related responses, suggesting a cohesive theme of steroid/lipid hormone metabolism. ","confidence":"Medium","size":13,"edges":22,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0034653","count":6},{"id":"GO:0070989","count":6},{"id":"GO:0001516","count":6},{"id":"GO:0060065","count":6},{"id":"GO:0071280","count":6}]},{"hash":"474407697669590358","title":"Lectin-mediated innate immunity and leukocyte recruitment","description":"The cluster centers on innate immune recognition via C-type lectin receptors and the lectin pathway of complement (GO:0001867, GO:0002223, GO:0071226), which are classic fungal-detection and response mechanisms. It is complemented by terms describing leukocyte adhesion and trafficking (leukocyte tethering/rolling, CAM production) and activation of basophils, as well as modulation of NK cell chemotaxis. Together, these suggest a coherent theme of fungal-recognition\u2013driven innate immune signaling and recruitment of leukocytes, with some developmental terms reflected in lymphatic involvement. Confidence: High.","confidence":"","size":13,"edges":12,"triangles":1,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":8},{"id":"GO:0001502","count":7},{"id":"GO:0001867","count":6},{"id":"GO:2000502","count":5},{"id":"GO:0045575","count":5}]},{"hash":"1715900176507926672","title":"Angiogenesis and vascular remodeling","description":"Top GO terms center on angiogenesis and its regulation, endothelial cell migration, Tie signaling, and collagen fibril organization; plasminogen activation adds ECM remodeling context. Together they describe a vascular development module involving angiogenic signaling and remodeling, with mechanotransduction also contributing.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0045766","count":3}]},{"hash":"58359177261554320","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071031","count":2},{"id":"GO:0090309","count":1},{"id":"GO:0010216","count":1},{"id":"GO:0010426","count":1},{"id":"GO:0003289","count":1}]},{"hash":"539853713135936099","title":"Cytoskeletal Dynamics in Division and Junction Maintenance","description":"The cluster centers on cytoskeletal and cell-architecture processes: spindle midzone and actomyosin ring assembly, regulation of microtubule-based processes, and chromosome organization, together with zonula adherens maintenance and nuclear migration. These themes indicate a cohesive role for microtubule/actin dynamics in cell division, cell shape, and cell\u2013cell adhesion, with ancillary ties to neuronal structure and organelle movement. ","confidence":"High","size":12,"edges":53,"triangles":125,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1990942","count":7},{"id":"GO:1990535","count":7},{"id":"GO:0045218","count":7},{"id":"GO:0032886","count":7},{"id":"GO:0036334","count":7}]},{"hash":"612078952980842708","title":"Eye development and retinal metabolism","description":"These proteins cluster around eye/retina-specific processes, including retinal metabolic processes and optic cup morphogenesis, with supporting craniofacial and neural development terms like face and hindbrain development, and related metabolic pathways (acetate, carbon utilization, GABA catabolism). This suggests a coherent theme of early ocular development coupled with retinal metabolism.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":12},{"id":"GO:0035115","count":12},{"id":"GO:0019544","count":12},{"id":"GO:0009450","count":12},{"id":"GO:0019413","count":12}]},{"hash":"142186683974804483","title":"GPCR-cAMP Signaling and Metabolic Regulation","description":"This cluster centers on GPCR-mediated activation of adenylyl cyclase and downstream cAMP signaling (GO:0010579, GO:0007190), with a clear association to metabolic processes (electronic transport chain, diet-induced thermogenesis, temperature response). Additional terms point to vascular signaling (blood pressure regulation) and small GTPase regulation, while retina development and pain perception may reflect broader tissue expression. Overall, the dominant theme is GPCR-cAMP signaling linked to metabolic regulation.","confidence":"High","size":12,"edges":6,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":6},{"id":"GO:0022900","count":6},{"id":"GO:0010579","count":6},{"id":"GO:0071502","count":5},{"id":"GO:0002024","count":5}]},{"hash":"1661961165399902729","title":"Cell Cycle and Gene Expression with Innate Immunity","description":"This cluster shows strong signals for cell division and mitotic cell cycle, plus DNA-templated transcription, splicing, and ubiquitin-mediated protein turnover, pointing to core cell-cycle and gene-expression machinery. The presence of innate immune defense terms suggests an immune function layer, but the dominant theme is cell proliferation and transcriptional regulation with an immune-contextual hint.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0000278","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0002467","count":3},{"id":"GO:0042787","count":3}]},{"hash":"112778165556216831","title":"Ribosome Biogenesis and Translation","description":"The terms are dominated by translation and ribosome-related processes\u2014translation itself, ribosome biogenesis and maturation of SSU/LSU rRNA, and even mitochondrial translation\u2014pointing to a core function in ribosome assembly and protein synthesis. A couple of outliers (viral genome replication and heterochromatin regulation) are likely incidental.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0042254","count":4},{"id":"GO:0042273","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0000463","count":2}]},{"hash":"114620970425903253","title":"Cell Cycle and DNA Repair Machinery","description":"Most of the top GO terms center on mitosis and genome maintenance (kinetochore localization, mitotic and meiotic cell cycles, G1/S transition, and DNA repair), suggesting the cluster is enriched for proteins involved in cell division and genomic integrity. The remaining terms point to neural signaling and immune/stress responses, which may reflect broader or pleiotropic roles of these proteins. Overall, the dominant theme is cell cycle control and DNA repair.","confidence":"Medium","size":12,"edges":62,"triangles":186,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034501","count":12},{"id":"GO:0060079","count":12},{"id":"GO:0051321","count":12},{"id":"GO:0042220","count":12},{"id":"GO:0000278","count":12}]},{"hash":"1294153607446951729","title":"ECM remodeling and immune signaling","description":"The cluster centers on ECM-related processes (hyaluronan metabolism, positive regulation of metallopeptidase activity) and cell-surface signaling pathways (integrin-mediated and Kit signaling). There is also substantial evidence for immune modulation (responses to fungal origin, negative regulation of TLR4 signaling, IL-2 production, Th2 differentiation) suggesting coordinated signaling between extracellular matrix dynamics and immune responses. Some terms (insulin stimulus, reproductive process) are peripheral but do not outweigh the dominant theme. ","confidence":"Medium","size":12,"edges":27,"triangles":20,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":9},{"id":"GO:0071226","count":6},{"id":"GO:0030212","count":5},{"id":"GO:1905050","count":5},{"id":"GO:0034144","count":5}]},{"hash":"114400678924228060","title":"Spliceosome-driven mRNA processing and export","description":"The strongest signals are mRNA splicing via the spliceosome, followed by related maturation steps such as polyadenylation, mRNA export from the nucleus, and mRNA stabilization; regulatory ncRNA-mediated silencing also appears, all pointing to a cohesive role in post-transcriptional mRNA processing and nuclear export.","confidence":"High","size":12,"edges":24,"triangles":19,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":8},{"id":"GO:0045292","count":8},{"id":"GO:0031047","count":7},{"id":"GO:0048026","count":7},{"id":"GO:1901407","count":7}]},{"hash":"931078110644819265","title":"Gene Expression and Cell Cycle Regulation","description":"The cluster centers on nucleic acid metabolism and transcription (RNA guanine-N7 methylation, ribosome biogenesis, DNA-templated transcription) and chromatin control (histone methylation regulation), along with cell cycle-related processes (cell division, septum digestion after cytokinesis) and protein turnover (SCF-dependent ubiquitin-proteasomal degradation). The presence of a stress-response term (hypoxia) further suggests regulation of gene expression under stress. Overall, the dominant theme ties gene expression machinery to cell cycle progression and related regulatory processes.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0036265","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0000747","count":3},{"id":"GO:2001162","count":2}]},{"hash":"1286785604616852147","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":23,"triangles":26,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":8},{"id":"GO:0007601","count":8},{"id":"GO:0000278","count":8},{"id":"GO:0051301","count":7},{"id":"GO:1905608","count":7}]},{"hash":"454689086566424561","title":"Ribosome biogenesis and translation","description":"The top GO terms cluster strongly around ribosome production and function: ribosome biogenesis, ribosomal large subunit export from the nucleus, LSU rRNA maturation, and translation (cytoplasmic and general). This indicates a cohesive group of proteins involved in ribosome assembly and protein synthesis; the antibiotic response, lipid A biosynthesis, and mitochondrial fission/respiration terms appear as ancillary connections rather than core themes. Overall, the dominant signal is ribosome biogenesis and translation.","confidence":"High","size":12,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0090141","count":2},{"id":"GO:0006412","count":2}]},{"hash":"2252258587700009396","title":"DNA Damage Response and Translation Regulation","description":"The cluster shows enrichment for DNA damage response terms (UV and gamma radiation exposure, p53-mediated apoptotic signaling) together with translation and transcription elongation terms and ribosome biogenesis, suggesting a theme where DNA damage signaling modulates transcriptional elongation and protein synthesis during stress.","confidence":"Medium","size":12,"edges":35,"triangles":45,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0032784","count":1},{"id":"GO:0045727","count":1},{"id":"GO:0042273","count":1},{"id":"GO:1904803","count":1}]},{"hash":"540002794566613844","title":"Unknown","description":"The top GO terms include plant-specific development (auxin polar transport, root meristem growth), diverse animal development (lung saccule development, skeletal muscle development, neuroblast polarity), plus cellular organization processes (localization to pericentriolar material) and telomerase assembly, and hypoxia response. The set spans very different biological contexts with no single cohesive function linking them, so a clear, representative label cannot be assigned.","confidence":"","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2000012","count":2},{"id":"GO:1900037","count":2},{"id":"GO:0043947","count":2},{"id":"GO:0010449","count":2},{"id":"GO:1905323","count":2}]},{"hash":"192444813929468073","title":"Inflammation and angiogenesis signaling regulators","description":"The dominant GO terms cluster around integrin-mediated signaling, TNF production, angiogenesis and endothelial/fibroblast migration, with supporting links to transcriptional regulation and STAT phosphorylation, plus a cellular/viral response. This points to proteins coordinating inflammatory signaling and vascular remodeling.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007229","count":9},{"id":"GO:0042535","count":9},{"id":"GO:0006351","count":9},{"id":"GO:0045766","count":9},{"id":"GO:0006397","count":9}]},{"hash":"521862963505187452","title":"Neural development and myelination","description":"The cluster contains several neural development-related GO terms\u2014positive regulation of synapse assembly, myelination, axonal fasciculation, and corpus callosum development\u2014along with related processes like vestibulo-ocular reflex and otolith morphogenesis, suggesting a cohesive theme of neural connectivity and maturation. There are a few outliers (innate immune response, renal tubule morphogenesis) that are less central to this theme, but they do not dominate the set. Therefore, the label reflects the dominant function of the cluster with reasonable specificity.","confidence":"Medium","size":12,"edges":36,"triangles":30,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0042552","count":3},{"id":"GO:0007413","count":3},{"id":"GO:0032474","count":3},{"id":"GO:0045087","count":3}]},{"hash":"434868126840886489","title":"Arabinogalactan protein glycosylation and cell-wall glycan biosynthesis","description":"The cluster\u2019s top GO terms center on arabinogalactan protein (AGP) metabolism and glycosylation pathways (AGP metabolic process, Hyp-O glycosylation, poly-N-acetyllactosamine biosynthesis, Lewis a epitope, and mucilage biosynthesis), pointing to glycan construction/modification in plant cell walls. Some development-related terms are present, but the dominant theme is AGP/glycan biosynthesis and cell-wall-associated processes, supporting a cohesive functional label.","confidence":"Medium","size":12,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0030311","count":3},{"id":"GO:0042248","count":3},{"id":"GO:0007299","count":3},{"id":"GO:0018258","count":3}]},{"hash":"1180540635274724376","title":"Unknown","description":"Top GO terms are highly diverse (toxic response, detoxification, chlorophyll breakdown, biotin/antibiotic biosynthesis, development and signaling). This lack of a cohesive function or shared pathway among the proteins makes a meaningful label unlikely. Therefore Unknown.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009636","count":6},{"id":"GO:0098869","count":5},{"id":"GO:0015996","count":5},{"id":"GO:0009102","count":4},{"id":"GO:0017000","count":4}]},{"hash":"127787979497167362","title":"Mitochondrial tRNA aminoacylation and translation","description":"This cluster is dominated by GO terms for mitochondrial tRNA aminoacylation across several amino acids (seryl, threonyl, glycyl, prolyl) and by translation, indicating a shared function in mitochondrial protein synthesis. Some outliers (B cell receptor signaling, skeletal muscle development) are present but represent a minority and likely reflect broader or misannotated associations; the core theme is mitochondrial translation machinery.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015966","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0070158","count":1},{"id":"GO:0006450","count":1}]},{"hash":"838827068183172168","title":"Angiogenesis and extracellular matrix remodeling","description":"The dominant GO terms center on collagen fibril organization and regulation of blood vessel formation, including both positive and negative controls of angiogenesis and endothelial cell migration, with supporting ERK signaling and processes like fibrinolysis and platelet regulation, pointing to vascular development and ECM remodeling as the cluster\u2019s unifying theme.","confidence":"High","size":12,"edges":9,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":4},{"id":"GO:0016525","count":3},{"id":"GO:0001525","count":2},{"id":"GO:0043537","count":2},{"id":"GO:0043536","count":2}]},{"hash":"839426451819135139","title":"NF-\u03baB Signaling and Proteasome Regulation","description":"The top terms cluster around NF-\u03baB pathway control (I\u03baB phosphorylation, NF-\u03baB transcription factor activity) and proteasomal ubiquitin-dependent protein degradation (ubiquitin-proteasome turnover, ufmylation), with an immune/stimulus context (GM-CSF response) and related regulatory processes. While there are a few ancillary signaling themes (ER signaling, metallopeptidase activity), the dominant theme ties to NF-\u03baB signaling and proteostasis.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001709","count":2},{"id":"GO:0097011","count":2},{"id":"GO:0051092","count":1},{"id":"GO:0033146","count":1},{"id":"GO:0032436","count":1}]},{"hash":"1406898182936549493","title":"Glutathione-Dependent Detox and Aromatic Amino Acid Catabolism","description":"The cluster centers on glutathione metabolism and detox pathways (glutathione-dependent methylglyoxal catabolism, xenobiotic/antibiotic response, and general detoxification), along with catabolic processes for phenylalanine and tyrosine. Some terms (e.g., transcription regulation, fibroblast proliferation) appear ancillary or noisy, but the dominant pattern points to detox and aromatic amino acid catabolism.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006357","count":2},{"id":"GO:0019243","count":2},{"id":"GO:0006559","count":2},{"id":"GO:0006749","count":2}]},{"hash":"1456760650086789355","title":"Ubiquitin-regulated development in muscle, nerve, kidney","description":"This cluster is dominated by ubiquitin-related terms (ubiquitin-dependent protein catabolic process and regulation of ubiquitination) along with developmental terms for skeletal muscle, nervous system, and renal morphogenesis/ function, suggesting a theme of ubiquitin-regulated tissue development across muscle, nerve, and kidney, with a few outliers (immune signaling, swimming).","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0050853","count":5},{"id":"GO:0042752","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0031397","count":5}]},{"hash":"115902456156496814","title":"Centrosome and microtubule organization","description":"The cluster is dominated by GO terms related to centrosome function, centriole replication, spindle assembly, astral microtubule nucleation, and microtubule polymerization, with additional links to mitotic cell cycle and cilium assembly, suggesting a cohesive role in centrosome/microtubule dynamics during cell division.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055085","count":2},{"id":"GO:0045671","count":2},{"id":"GO:0051497","count":2},{"id":"GO:0035186","count":1},{"id":"GO:0051299","count":1}]},{"hash":"978504167068005244","title":"Ion and Sugar Transporters","description":"Most GO terms point to membrane transport across the cell boundary for ions (sodium, nitrate, phosphate) and nutrients/sugars (sialic acid, fucose metabolism). This suggests the cluster is enriched for ion/nutrient transporters and related carbohydrate/nitrogen handling rather than a single developmental program. A few outlier terms (skin development, multicellular organism development, ribosomal RNA maturation) are less consistent with the main theme but do not override the transport focus.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0000462","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0015739","count":2}]},{"hash":"1136778429389176614","title":"Development and Nucleotide Metabolism","description":"The cluster shows strong signals for developmental processes (bone and nervous system development, organ regeneration) alongside nucleotide and purine biosynthesis and nucleoside metabolism, suggesting a group of proteins linked to growth and the supply of building blocks for development. Some annotations like fungal-type cell wall organization seem noisy, but the core theme remains developmental biology coupled with nucleotide metabolism.","confidence":"Medium","size":11,"edges":6,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0031100","count":2},{"id":"GO:0043086","count":2},{"id":"GO:0034418","count":2}]},{"hash":"1723681109609654312","title":"Amino acid and cofactor biosynthesis","description":"These proteins show strong enrichment for biosynthetic processes, including amino acid synthesis (lysine, isoleucine, tryptophan, histidine, glutamate, glutamine) and cofactors (biotin, protoporphyrinogen IX), plus related metabolism like pyruvate biosynthesis. The common theme is synthesis of foundational metabolites and cofactors, pointing to a metabolic biosynthesis module. ","confidence":"High","size":11,"edges":35,"triangles":51,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0019878","count":4},{"id":"GO:0009097","count":2},{"id":"GO:0000162","count":2},{"id":"GO:0042866","count":2},{"id":"GO:0009102","count":2}]},{"hash":"2021287454449826310","title":"Muscle ECM Remodeling and Redox Homeostasis","description":"The cluster combines strong redox-related processes (redox homeostasis, oxidant detoxification, peptidyl-cysteine oxidation) with muscle-associated features (extracellular matrix organization, skeletal muscle fiber development) and mitochondrial-related activity (cytochrome complex assembly, lipid and methylamine metabolism), suggesting a theme of redox-balanced muscle remodeling and energy metabolism. A couple of immune signaling terms (natural killer cell\u2013mediated cytotoxicity, regulation of MAPK cascade) are present but appear less central to the core muscle/redox function. ","confidence":"Medium","size":11,"edges":32,"triangles":53,"max_degree":8,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0045454","count":5},{"id":"GO:0098869","count":5},{"id":"GO:0030198","count":4},{"id":"GO:0048741","count":4},{"id":"GO:0030416","count":4}]},{"hash":"1023625942482812649","title":"Hypoxia-driven angiogenic signaling and proliferation","description":"These terms cluster around hypoxia-responsive signaling that promotes angiogenesis and cell proliferation, with kinase-driven regulation (GTPase activity, serine/threonine kinase activity, autophosphorylation) and motifs of complex formation (protein heterotrimerization). The angiogenesis-related branching in blood vessel morphogenesis and hyaluronan metabolism point to extracellular matrix remodeling during new vessel formation. Overall, this appears to be a hypoxia-activated signaling module driving endothelial proliferation and vascular development.","confidence":"High","size":11,"edges":8,"triangles":2,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070208","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0051028","count":4}]},{"hash":"1505728953418319148","title":"Mitotic cell cycle and ER-Golgi transport","description":"This cluster is driven by mitosis/cell division terms (mitotic cell cycle, cell division, mitotic spindle assembly) and vesicle trafficking terms between the ER and Golgi (COPII budding, ER-to-Golgi, Golgi-to-ER transport), suggesting proteins that coordinate the secretory pathway with cell division and growth. Developmental terms like brain and spermatid development appear as broader context.","confidence":"High","size":11,"edges":27,"triangles":19,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":6},{"id":"GO:0008283","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0090114","count":5},{"id":"GO:0051301","count":5}]},{"hash":"765887894660654003","title":"Mitochondrial translation and ribosome biogenesis","description":"The cluster is dominated by terms related to ribosome function and protein synthesis, including mitochondrial translation, translation, ribosome biogenesis, ribosomal subunit assembly, and rRNA processing. These points indicate a cohesive theme around ribosome production and mitochondrial gene expression, with a few outlier terms (apoptotic process, symbiont entry) that do not define the main function. Overall, the label captures the central shared activity of the cluster.","confidence":"High","size":11,"edges":43,"triangles":79,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0032543","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0006351","count":1},{"id":"GO:0006355","count":1}]},{"hash":"632954886363747850","title":"Neural development and axon guidance","description":"This cluster is dominated by GO terms tied to neuronal development, including dorsal root ganglion morphogenesis, sympathetic neuron projection guidance/extension, cerebellar Purkinje cell layer development, and axon extension in guidance. While a few terms refer to unrelated processes, the common theme is neural development and axon pathfinding, suggesting a cohesive functional group around nervous system formation and wiring.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006364","count":1},{"id":"GO:0038095","count":1},{"id":"GO:2001199","count":1},{"id":"GO:0060982","count":1},{"id":"GO:1901166","count":1}]},{"hash":"104402401863499636","title":"Peroxisomal glyoxylate cycle and photorespiration","description":"The GO terms point to glyoxylate and glycolate catabolism, the glyoxylate cycle, photorespiration, and related nitrogen metabolism (ammonia assimilation, L-glutamate biosynthesis). These are hallmark peroxisomal pathways in plant metabolism, linking glyoxylate/glycolate turnover with photorespiration. This suggests the cluster represents peroxisomal glyoxylate/glycolate processing and the photorespiratory pathway.","confidence":"High","size":11,"edges":50,"triangles":124,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0009436","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0097054","count":3},{"id":"GO:0019676","count":3},{"id":"GO:0046296","count":3}]},{"hash":"1937446130151466865","title":"Innate immunity, complement activation, and coagulation","description":"This cluster centers on innate immune responses to bacterial components (lipopolysaccharide), activation of the complement system (lectin pathway), and regulation of coagulation and fibrinolysis, along with inflammation-associated tissue remodeling. While some oxidant-detoxification terms appear, the overall theme ties to inflammation, immune defense, and coagulation processes, suggesting these proteins function together in early immune response and wound repair contexts.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0098869","count":5},{"id":"GO:0032496","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0046718","count":3}]},{"hash":"629330274114051593","title":"Neuronal development and synaptic vesicle release","description":"The top terms cluster around nervous system development, evoked neurotransmitter secretion, and SNARE complex disassembly, which together point to neuronal differentiation and synaptic vesicle trafficking. Additional terms involving JNK signaling and cellular responses to mechanical stimuli fit within neural signaling and cellular stress contexts. Some immune-related terms appear, but the dominant theme is neuronal development and synaptic function.","confidence":"Medium","size":11,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0032707","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0042088","count":3},{"id":"GO:0046330","count":3}]},{"hash":"1819745385300009298","title":"Proteostasis and ECM Remodeling","description":"This cluster shows enrichment for protein turnover and ECM regulation: ubiquitin-dependent protein catabolic process, proteasome assembly, and positive regulation of metallopeptidase activity, together with negative regulation of extracellular matrix assembly and cell-matrix adhesion. These features point to a cohesive theme around proteolysis and remodeling of the extracellular matrix. A few GO terms such as chlorophyll biosynthetic process, stamen formation, and cerebellar Purkinje cell layer development appear unrelated and likely reflect cross-species annotation noise.","confidence":"Medium","size":11,"edges":12,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":4},{"id":"GO:0015995","count":4},{"id":"GO:0006511","count":4},{"id":"GO:0048455","count":4},{"id":"GO:0043248","count":4}]},{"hash":"2155847894463248237","title":"Neural development and synaptic signaling","description":"The terms overwhelmingly point to neural and sensory functions: excitatory postsynaptic potential, long-term synaptic potentiation, visual perception, and Schwann cell development. A neural development/synaptic signaling theme is supported by these prominent terms, while a few outliers (abscisic acid signaling, mitotic cell cycle, heart development) may reflect broader or pleiotropic roles rather than a core function of the cluster.","confidence":"Medium","size":11,"edges":8,"triangles":1,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0009738","count":7},{"id":"GO:0060079","count":7},{"id":"GO:0010800","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0000086","count":7}]},{"hash":"2046651972707716237","title":"Cell cycle control and growth signaling","description":"The proteins cluster around core proliferative processes: DNA replication, cell cycle progression, and centrosome cycle, complemented by growth-regulating pathways such as Hippo and Wnt signaling and transcriptional activation. This combination points to a theme of proliferation control and growth signaling, with differentiation and apoptosis components adding balance.","confidence":"High","size":11,"edges":13,"triangles":3,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045944","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0035329","count":5},{"id":"GO:0030216","count":5},{"id":"GO:0006915","count":5}]},{"hash":"1022181769611693287","title":"ER Protein Quality Control and Stress Response","description":"Top GO terms largely describe ER-associated protein quality control (ERAD), SRP-dependent targeting to the ER, and regulation of stress-induced apoptosis, plus negative control of inclusion body formation. This converges on maintaining proteome integrity under stress, i.e., ER- and protein quality-control pathways. A few outlier terms (iron-sulfur cluster assembly) are less connected but do not derail the main signal.","confidence":"Medium","size":11,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0090084","count":1},{"id":"GO:1903751","count":1},{"id":"GO:0006616","count":1},{"id":"GO:0000742","count":1}]},{"hash":"856185764545291357","title":"Histone Ubiquitination and Cell Cycle Regulation","description":"This cluster is dominated by ubiquitin-dependent protein catabolism and histone catabolic processes, plus mitotic cell cycle terms, indicating a core role in chromatin remodeling via ubiquitination during cell division. Additional terms (histone H2A K63 ubiquitination, H4-K20 methylation, JNK regulation, and V(D)J recombination) fit within chromatin-regulatory and signaling contexts that accompany cell-cycle control.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0036205","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0090073","count":4}]},{"hash":"582282236308682909","title":"Cerebellar Development and Growth Control","description":"The top GO terms cluster around cerebellar development, with specific references to Bergmann glial cell differentiation and cerebellar cortex formation, paired with growth and signaling pathways such as Hippo, insulin receptor signaling, and regulation of the cell cycle (CDK activity and proliferation). Although there is an immune-related term (T cell receptor signaling), the strongest pattern centers on cerebellar development and proliferation control, justifying a label focused on cerebellar development and growth signaling.","confidence":"Medium","size":11,"edges":38,"triangles":60,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045736","count":10},{"id":"GO:0034501","count":10},{"id":"GO:2001275","count":9},{"id":"GO:0060020","count":9},{"id":"GO:0050852","count":9}]},{"hash":"2255936578905788938","title":"Reproductive hormone and prostaglandin metabolism","description":"Top terms show a strong emphasis on prostaglandin biosynthesis and reproductive development (uterus and female gonad development), with additional signals of hormone metabolism (androgen, aldosterone) and related endocrine regulation. This points to a cohesive theme of lipid mediator\u2013driven signaling in female reproduction, potentially connecting prostaglandin production to steroid hormone pathways and related metabolic responses (retinoic acid/vitamin D signaling). Some terms are broader, but the core pattern supports labeling the cluster as related to reproductive prostaglandin and hormone metabolism.","confidence":"Medium","size":11,"edges":8,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":4},{"id":"GO:0060065","count":4},{"id":"GO:0008585","count":4},{"id":"GO:0034653","count":3},{"id":"GO:0070989","count":3}]},{"hash":"2055178869215639585","title":"Developmental gene expression regulation","description":"This cluster centers on regulation of gene expression across transcription and translation, with GO terms spanning negative regulation of RNA Pol II transcription, assembly and regulation of translation initiation complexes, and nuclear mRNA surveillance. Development-related terms such as stem cell differentiation, neuron differentiation, and germarium-derived cystoblast division suggest these proteins participate in controlling cell fate during development. The mix of transcriptional and translational control points to a broader role in coordinating gene expression rather than a single enzymatic activity, making \u201cDevelopmental gene expression regulation\u201d a plausible umbrella label.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0048863","count":2},{"id":"GO:0000338","count":2},{"id":"GO:0048142","count":2},{"id":"GO:0070196","count":2}]},{"hash":"1071595208431291881","title":"B cell differentiation and humoral immunity","description":"This cluster centers on B cell\u2013driven immune functions, highlighted by terms for B cell differentiation, humoral immune response mediated by antibodies, cytokine production, and proteins localized to the cell surface, all indicative of antibody-mediated immunity and related signaling. Some terms reflect broader immune or tissue contexts (e.g., apoptotic signaling, skin development), but the predominant theme is B cell\u2013mediated humoral responses.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008625","count":3},{"id":"GO:0030183","count":3},{"id":"GO:0010467","count":2},{"id":"GO:0002876","count":2},{"id":"GO:0002925","count":2}]},{"hash":"576378106516880545","title":"Calcium signaling and neurotransmission","description":"This cluster is dominated by terms tied to signaling pathways and neural communication: GABAergic and glutamatergic receptor signaling, GPCR acetylcholine signaling, store-operated calcium channel activation, and phosphoinositide catabolism that feeds calcium release. The presence of epidermal growth factor stimulus and endothelial migration suggests broader signal transduction roles, but the strongest recurring pattern is calcium-dependent signaling coupled to synaptic transmission, explaining the chosen label.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071364","count":4},{"id":"GO:0007213","count":3},{"id":"GO:0043536","count":3},{"id":"GO:1902634","count":3},{"id":"GO:0032228","count":3}]},{"hash":"250118025540066485","title":"Xenobiotic and metabolite membrane transport","description":"The top GO terms show transmembrane transport across the plasma membrane for a wide range of substrates\u2014xenobiotics, vitamins, ions, sialic acid, urate, and fucose\u2014indicating a function centered on transporting diverse molecules rather than a single substrate. The cluster's numerous transport-related terms and membrane-associated processes support labeling these proteins as broad-spectrum membrane transporters.","confidence":"High","size":11,"edges":47,"triangles":107,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":11},{"id":"GO:0035461","count":11},{"id":"GO:0071805","count":10},{"id":"GO:0042908","count":10},{"id":"GO:0042891","count":10}]},{"hash":"1658597097161744090","title":"RNA Pol II Transcription Initiation and Promoter Assembly","description":"These proteins are collectively associated with transcription initiation by RNA polymerase II, including promoter binding, preinitiation complex assembly, and open complex formation, as reflected by GO terms like transcription initiation at RNA Pol II promoters and preinitiation complex assembly. A ribosomal biogenesis term appears but is less representative; the overall pattern points to Pol II transcription initiation functions.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":2},{"id":"GO:0006355","count":1},{"id":"GO:0070893","count":1},{"id":"GO:0090074","count":1},{"id":"GO:0006351","count":1}]},{"hash":"324306403200123966","title":"Transmembrane Xenobiotic and Nutrient Transporters","description":"This cluster is characterized by GO terms for transmembrane transport of xenobiotics and nutrients (xenobiotic, vitamin, sialic acid, urate, and other nutrient transports) across membranes, plus related ion and selenite transport, indicating a shared role as membrane transport proteins handling foreign and nutritional compounds.","confidence":"High","size":11,"edges":13,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":11},{"id":"GO:0035461","count":11},{"id":"GO:0042891","count":9},{"id":"GO:0071805","count":9},{"id":"GO:0042908","count":9}]},{"hash":"689716198912550707","title":"Developmental organogenesis and germline development","description":"This cluster\u2019s GO terms cluster around development of brain, heart, and gonads, including germ-line cell division, along with related transcription and mitotic processes. While some terms are obsolete and there are no observed interactions, the recurring theme points to proteins involved in developmental regulation and basic cell-cycle control, spanning organogenesis and germline contexts.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007018","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0071456","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0051567","count":2}]},{"hash":"911228944972186336","title":"Autophagy and organelle trafficking regulation","description":"This cluster is enriched for autophagy-related processes, including negative regulation of autophagosome maturation and aggrephagy, suggesting a focus on autophagy and protein quality control. Other terms point to membrane trafficking and organelle dynamics (ER membrane protein insertion, GPCR internalization, mitochondrial fusion), indicating a broader theme of intracellular trafficking with regulation of autophagy. Overall, a cohesive label is Autophagy and organelle trafficking regulation.","confidence":"Medium","size":11,"edges":53,"triangles":148,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0010216","count":5},{"id":"GO:1901097","count":5},{"id":"GO:0010637","count":4},{"id":"GO:1901340","count":4},{"id":"GO:0006357","count":4}]},{"hash":"485470680142510394","title":"Angiogenesis and ECM Remodeling","description":"The top GO terms cluster around promoting angiogenesis and remodeling the extracellular matrix (collagen fibril organization, fibrinolysis) and modulating platelet/endothelial function, suggesting vascular development and ECM regulation as the core theme; the neural synaptic term seems less representative of the overall cluster.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051968","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0090331","count":3},{"id":"GO:2000352","count":3}]},{"hash":"329073977057177911","title":"Lectin pathway activation and leukocyte adhesion","description":"The top GO terms point to innate immune recognition and response, especially lectin-mediated complement activation, C-type lectin receptor signaling, leukocyte tethering/rolling, and basophil activation, suggesting a cluster centered on lectin-driven immune activation and leukocyte recruitment. Some terms about development (cartilage condensation, lymph vessel morphogenesis) may reflect broader context or secondary associations, but the immune signaling theme is predominant.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":6},{"id":"GO:0001502","count":4},{"id":"GO:2000502","count":4},{"id":"GO:0071226","count":4},{"id":"GO:0045575","count":4}]},{"hash":"1901690947162636720","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":3},{"id":"GO:0034354","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0010976","count":2}]},{"hash":"305209065401695025","title":"Mitochondrial transport and fission","description":"The terms point to mitochondrial membrane transport of various cofactors and nucleotides (e.g., thiamine pyrophosphate, pyridoxal phosphate, glycine, ATP) and mitochondrial membrane fission processes, suggesting a cohesive theme of mitochondrial transport and dynamics. Some broader metabolic terms (insulin response, liver regeneration) appear peripheral but do not override the central mitochondrial focus.","confidence":"High","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030974","count":4},{"id":"GO:0032869","count":4},{"id":"GO:0000002","count":4},{"id":"GO:0070542","count":4},{"id":"GO:0036233","count":4}]},{"hash":"1855372463506860455","title":"Coagulation, complement activation, and tissue remodeling","description":"Dominant GO terms point to immune and proteolytic remodeling processes, with complement activation via the lectin pathway, plasminogen activation, fibrinolysis, and angiogenesis. A few neuron-related terms are present but likely reflect shared proteolytic or extracellular matrix contexts rather than a neural-specific function. Thus, the cluster best reflects coagulation-immune remodeling and tissue remodeling activities.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0007413","count":2},{"id":"GO:0030225","count":2},{"id":"GO:0030851","count":2},{"id":"GO:0051968","count":2}]},{"hash":"2223147360239873096","title":"Hypoxia-Responsive Neural and Vascular Development","description":"The cluster shows enrichment for cellular response to hypoxia, angiogenesis, and peripheral nervous system myelination, alongside neural signaling terms (neurotransmitter secretion, memory) and broad developmental processes. This suggests proteins involved in neural development with concurrent vascular and hypoxic-stress context, rather than a single precise function. Some terms reflect general development, but the overarching theme is coordination of neural maturation with vascular and hypoxic cues.","confidence":"Medium","size":11,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0072221","count":2},{"id":"GO:0043065","count":2}]},{"hash":"2209654187054881023","title":"Auditory and Autonomic Neural Signaling","description":"This cluster is dominated by terms tied to sound perception and cochlea development, plus neural signaling and autonomic regulation (cholinergic synaptic transmission, norepinephrine secretion, heart rate regulation, potassium transport, drug response). Together they suggest a theme around auditory system function and broader neural control of physiology and behavior, though one term about cartilage morphogenesis appears less connected.","confidence":"Medium","size":11,"edges":16,"triangles":8,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0042220","count":3},{"id":"GO:0001988","count":2},{"id":"GO:0003428","count":2},{"id":"GO:0090102","count":2}]},{"hash":"1944020754276622380","title":"Complement Activation and Adhesion","description":"The Top Terms are heavily dominated by complement system terms (classical, alternative, lectin pathways) and membrane attack complex activation, with additional adhesion-related GO terms (cell-matrix and cell-cell adhesion). This suggests a cluster centered on extracellular immune defense via complement, with supporting adhesion functions; other terms appear ancillary. ","confidence":"High","size":11,"edges":3,"triangles":0,"max_degree":2,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0006957","count":6},{"id":"GO:0007160","count":6},{"id":"GO:0051918","count":6},{"id":"GO:0044332","count":6},{"id":"GO:0006958","count":6}]},{"hash":"1061286509424558951","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":6},{"id":"GO:0042372","count":5},{"id":"GO:0006574","count":5},{"id":"GO:0009234","count":5},{"id":"GO:0006635","count":5}]},{"hash":"286492721065835873","title":"Unknown","description":"The top GO terms span liver and lung development, various biosynthetic processes (poly-hydroxybutyrate, clavulanic acid, spermidine, collagen), sporulation, and xenobiotic/amine responses, covering both developmental and microbial processes with little unifying function. This lack of a coherent theme across the cluster makes a concise label impractical, so I label it Unknown.","confidence":"","size":10,"edges":15,"triangles":9,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001889","count":4},{"id":"GO:0030324","count":3},{"id":"GO:0042619","count":3},{"id":"GO:0030435","count":3},{"id":"GO:0019556","count":2}]},{"hash":"204046744918290152","title":"ncRNA-regulated RNA processing and stress granule localization","description":"This cluster is dominated by RNA-centric terms: regulatory ncRNA-mediated gene silencing, positive regulation of mRNA splicing via the spliceosome, snoRNA release from pre-rRNA, and protein localization to cytoplasmic stress granules, all pointing to coordinated RNA processing and ncRNA regulation under stress. A hint of mitochondrial large ribosomal subunit assembly broadens to RNA handling in organelles, while obsolete terms may reflect older annotations. Overall, the theme centers on RNA metabolism and stress-related regulation rather than a single enzymatic pathway.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":10},{"id":"GO:0048026","count":10},{"id":"GO:1903608","count":9},{"id":"GO:0014070","count":8},{"id":"GO:0006306","count":8}]},{"hash":"939799246360992342","title":"Cytoskeleton Organization and Microtubule Dynamics","description":"The terms cluster around mitotic microtubule processes (chromosome alignment, centrosome separation) and regulation of microtubule-based activities, with supporting references to cell junction maintenance, neuron structure, and chloroplast movement\u2014points to a core role in cytoskeletal organization across contexts.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007080","count":5},{"id":"GO:0007100","count":5},{"id":"GO:1990942","count":4},{"id":"GO:1990535","count":4},{"id":"GO:0045218","count":4}]},{"hash":"895608009732562476","title":"Cell division and development","description":"The cluster is enriched in cell division and cell cycle regulation terms (cell division, regulation of cell cycle, mitotic metaphase chromosome recapture), indicating a core link to proliferative/mitotic processes. Additional terms cover broader developmental contexts (root development, hair follicle placode formation) and related functions (neuron projection maintenance), suggesting participation in development programs that coordinate proliferation with differentiation.","confidence":"High","size":10,"edges":16,"triangles":16,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048364","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0000743","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007050","count":3}]},{"hash":"1521377304461668571","title":"Ribosome assembly and SRP-mediated protein targeting","description":"The cluster is dominated by GO terms for translation, ribosomal large subunit assembly, and SRP-dependent cotranslational protein targeting to membranes, indicating a core connection to ribosome function and co-translational protein targeting to membranes. The presence of a few outlier terms (flagellum organization, interleukin-4 response, cobalamin biosynthesis) suggests some multifunctional proteins or annotation noise, but the central theme remains translation and membrane targeting.","confidence":"Medium","size":10,"edges":32,"triangles":59,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0000027","count":3},{"id":"GO:0006616","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0006614","count":2}]},{"hash":"1835994366237635314","title":"Glycoprotein Biosynthesis in Epithelial Morphogenesis","description":"The cluster centers on glycosylation-related biosynthetic processes (heparan sulfate proteoglycan, poly-N-acetyllactosamine, arabinogalactan protein, O-linked glycosylation) and on epithelial polarity and cell adhesion (follicle epithelium polarity maintenance, follicle cell adhesion), with developmental terms across insects and plants, suggesting a unified theme where extracellular glycoproteins shape tissue morphogenesis across species.","confidence":"High","size":10,"edges":24,"triangles":16,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0015012","count":4},{"id":"GO:0030311","count":3},{"id":"GO:0042248","count":3},{"id":"GO:0007299","count":3},{"id":"GO:0018258","count":3}]},{"hash":"307253822964953262","title":"ER-to-Golgi trafficking and mitotic processes","description":"The strongest signals are ER-to-Golgi vesicle trafficking and COPII budding, indicating active secretory pathway organization. Several terms also point to cell cycle and mitosis (mitotic spindle assembly, mitotic cell cycle, cell population proliferation), with additional translation initiation and developmental terms that fit a broader growth and production context. Hence the label ER-to-Golgi trafficking and mitotic processes captures the core themes represented in the cluster.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0090307","count":4},{"id":"GO:0001731","count":4}]},{"hash":"1496663035498628100","title":"Histone acetylation and chromatin remodeling","description":"The top GO terms cluster around acetylation events (histone H4 acetylation, N-terminal serine acetylation, spermine acetylation) and chromatin-related processes (subtelomeric heterochromatin formation, centromeric cohesion), suggesting a shared theme of chromatin modification and regulation, despite some metabolic outliers.","confidence":"Medium","size":10,"edges":17,"triangles":7,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0010125","count":6},{"id":"GO:0001525","count":6},{"id":"GO:0046208","count":6},{"id":"GO:0071962","count":6},{"id":"GO:0017198","count":6}]},{"hash":"1617885161469305266","title":"Neuronal development and cytoskeletal dynamics","description":"The Top Terms point to brain development, dendrite and spine formation, and tubulin complex assembly, alongside processes like ER-Golgi transport and GTPase activity regulation. Together, these suggest a cohesive theme of neuronal morphogenesis and cytoskeletal remodeling with associated trafficking. A single outlier term (subtelomeric heterochromatin formation) is present but does not dominate the cluster. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006348","count":2},{"id":"GO:0006888","count":2},{"id":"GO:1904263","count":2}]},{"hash":"1871469387490014960","title":"Immune Activation and Developmental Signaling","description":"The top GO terms point to immune cell signaling and activation (activated T cell proliferation; transitional B cell differentiation; integrin signaling) alongside developmental and growth-related pathways (VEGF receptor signaling; skeletal system development; regulation of cell growth). Some terms also touch on cell cycle and kinetochore localization, suggesting broader signaling roles during development and immune maturation. Overall, the cluster appears to reflect signaling networks coordinating immune activation with developmental/tissue-growth processes.","confidence":"Medium","size":10,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048010","count":4},{"id":"GO:0071333","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0050798","count":3},{"id":"GO:0034501","count":3}]},{"hash":"1726138642247956901","title":"Unknown","description":"The GO terms are highly diverse (metabolic processes, immune/inflammatory mediator production, thyroid hormone metabolism/transport, chitin catabolic, sensory perception of sound) and include obsolete annotations, with no clear unifying function or pathway linking the proteins. The absence of edges also suggests no detected interactions to define a cohesive cluster. Therefore I cannot assign a specific, representative label beyond Unknown.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006522","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0033014","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0002532","count":2}]},{"hash":"878789025076545824","title":"Antiviral RNAi and RNA editing","description":"The cluster combines innate antiviral signals (innate immune response, response to virus, interferon-alpha) with RNA processing and editing pathways (pre-miRNA processing, siRNA processing, regulation of miRNA metabolism, and adenosine-to-inosine editing). This points to a module where RNA silencing and RNA editing modulate antiviral defense and gene regulation, with some links to kinase signaling and proliferation. ","confidence":"Medium","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0009615","count":1},{"id":"GO:0031054","count":1},{"id":"GO:0035455","count":1},{"id":"GO:0070919","count":1}]},{"hash":"1558796342445386825","title":"Prostaglandin synthesis and anti-inflammatory signaling","description":"The cluster is dominated by prostaglandin biosynthesis and COX pathway terms, plus negative regulation of inflammation (TNF production and acute inflammatory response), pointing to prostaglandin-driven inflammatory regulation as the core theme. Other terms (glutathione metabolism, insulin and glucocorticoid responses, ethanol response, nucleotide-excision repair) suggest broader stress/metabolic context but are secondary to the inflammatory signaling focus.","confidence":"Medium","size":10,"edges":40,"triangles":84,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":10},{"id":"GO:0032720","count":9},{"id":"GO:0002674","count":9},{"id":"GO:0032869","count":9},{"id":"GO:0071385","count":9}]},{"hash":"1829678969739661843","title":"Hormone metabolism and reproductive development","description":"This cluster centers on endocrine and vitamin-related processes: prostaglandin biosynthesis, androgen metabolism, retinoic acid and vitamin A pathways, vitamin D response, and aldosterone-related regulation of blood volume, alongside uterus development. A couple of stress-response terms (copper ion response, nematode response) appear but are secondary to the dominant hormone/vitamin metabolism theme.","confidence":"Medium","size":10,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0034653","count":2},{"id":"GO:0070989","count":2},{"id":"GO:0001516","count":2},{"id":"GO:0060065","count":2},{"id":"GO:0071280","count":2}]},{"hash":"1864854331532228","title":"Steroid Hormone Biosynthesis","description":"The top GO terms center on steroid production\u2014androgen metabolic process, testosterone biosynthetic process, and estrogen biosynthetic process\u2014indicating a primary focus on steroid hormone biosynthesis. Related lipid metabolism terms (retinal, sphingolipid) appear less prominently, and antibiotic-related terms seem incidental. This supports labeling the cluster as Steroid Hormone Biosynthesis with high confidence.","confidence":"High","size":10,"edges":10,"triangles":3,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0008209","count":5},{"id":"GO:0061370","count":5},{"id":"GO:0042574","count":4},{"id":"GO:0006666","count":4}]},{"hash":"193884292742361824","title":"Nuclear RNA processing and transcription regulation","description":"The cluster\u2019s top GO terms center on nuclear RNA metabolism and transcription control\u2014splicing, mRNA decapping/deadenylation, rRNA maturation, nuclear import, and RNA Pol II transcription termination\u2014indicating a cohesive theme of nuclear RNA processing and regulation of transcription. Some stress-response terms appear, but the dominant signal supports RNA processing/transcription focus.","confidence":"High","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":6},{"id":"GO:0051170","count":5},{"id":"GO:0000290","count":5},{"id":"GO:0008334","count":5},{"id":"GO:0009737","count":5}]},{"hash":"2079038051628860873","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":43,"triangles":105,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0042254","count":5},{"id":"GO:0046330","count":3},{"id":"GO:0006407","count":2},{"id":"GO:0031118","count":2}]},{"hash":"1229488616683742667","title":"Ubiquitin-proteasome control of neural development","description":"The top GO terms cluster around positive regulation of ubiquitin-protein transferase activity and SCF-dependent proteasomal degradation, together with neuron projection development and synapse assembly, pointing to a module where ubiquitination regulates neuronal connectivity and synapse formation. Some terms (interferon-beta response and abscisic acid response) appear peripheral or noisy but do not undermine the central ubiquitin-neural theme.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0051443","count":10},{"id":"GO:0031146","count":10},{"id":"GO:0010976","count":10},{"id":"GO:0035458","count":10},{"id":"GO:0009737","count":10}]},{"hash":"267799454883237453","title":"Mammary gland development and angiogenesis","description":"The top GO terms center on mammary gland development (nipple morphogenesis, signaling in gland development) and angiogenesis, along with extracellular matrix\u2013cell signaling, suggesting a coherent theme of mammary tissue morphogenesis coupled with vascular remodeling. Immune-related terms like complement activation appear peripheral and do not define the cluster\u2019s primary function.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060427","count":2},{"id":"GO:0060658","count":2},{"id":"GO:0060764","count":1},{"id":"GO:0045766","count":1},{"id":"GO:0035426","count":1}]},{"hash":"1913089800405863214","title":"Immune signaling and angiogenesis","description":"The top GO terms indicate strong representation of adaptive immune signaling (activated T cell proliferation, beta selection, B cell receptor signaling, B cell differentiation) together with angiogenic pathways (VEGF receptor signaling, angiogenesis) and related processes (integrin signaling, apoptosis regulation). This points to a cluster of proteins involved in immune cell activation/development that also interface with vascular growth and cell survival signals.","confidence":"High","size":10,"edges":19,"triangles":12,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048010","count":10},{"id":"GO:0050798","count":10},{"id":"GO:0043366","count":10},{"id":"GO:0043068","count":10},{"id":"GO:0061387","count":10}]},{"hash":"1355878034719176700","title":"Plant secondary cell wall biosynthesis","description":"Most top GO terms point to plant cell wall biology and the construction of secondary walls (e.g., cell wall organization, plant-type secondary cell wall biogenesis, glucuronoxylan biosynthetic process, pollen exine formation). A few proteoglycan-related terms appear, which are less typical in plants and may reflect annotation noise, but the dominant signal is plant cell wall biosynthesis.","confidence":"High","size":10,"edges":30,"triangles":35,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":3},{"id":"GO:0042493","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0010417","count":2},{"id":"GO:0050650","count":2}]},{"hash":"1095433126931789581","title":"ER Stress and Protein Folding","description":"The top GO terms center on responses to unfolded proteins and regulation of translation initiation in response to ER stress, indicating a core theme of protein quality control under stress. The presence of other unrelated terms (e.g., photosynthesis, prostate development) likely reflects annotation noise or multi-species data, but the ER stress/protein folding signal is clear.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0036494","count":3},{"id":"GO:0006986","count":3},{"id":"GO:0009820","count":2},{"id":"GO:2001162","count":2}]},{"hash":"1034904277130686309","title":"Neural Synaptic Transmission and Plasticity","description":"The cluster is best captured by neural-related GO terms: positive regulation of glutamatergic synaptic transmission, long-term synaptic depression, and regulation of grooming behavior point to neuronal signaling and synaptic plasticity. Potassium ion export regulation also relates to neuronal excitability, while centrosome localization and actin cytoskeleton processes underpin cell architecture supporting synapses. A few terms like engulfment of apoptotic cells may reflect glial clearance in neural tissue; uterus and osteoclast development are less related and may reflect broader cellular roles of the proteins. Overall, the dominant neural synaptic functions provide the most coherent theme.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":3},{"id":"GO:0010641","count":3},{"id":"GO:2001205","count":3},{"id":"GO:0051968","count":3},{"id":"GO:0043652","count":3}]},{"hash":"587182277667702526","title":"Cytoskeletal Dynamics in Development and Signaling","description":"The cluster centers on cytoskeletal regulation\u2014GTPase activity, barbed-end actin capping, actin crosslinking, and cell polarity with spindle assembly\u2014alongside developmental and signaling roles (heart development, myelination, TGF-beta response, and synaptic plasticity). This points to proteins coordinating cytoskeletal remodeling with developmental signaling in neural and cardiac contexts, justifying a label focused on cytoskeletal dynamics in development.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0035562","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0051016","count":2}]},{"hash":"638874142848310994","title":"Embryonic organogenesis and placental development","description":"The top GO terms center on embryonic development and tissue differentiation, including pancreatic cell development, cartilage morphogenesis, trophoblast giant cell differentiation, placental/embryonic placenta development, left-right patterning, and endocardial cushion formation EMT, plus endocrine system development. These collectively point to a shared theme of early organ formation and differentiation. A few metabolic/transport terms appear but are minor. No network edges are present, so the label reflects functional themes rather than interaction structure.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060972","count":2}]},{"hash":"670713350935615879","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":18,"triangles":12,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0009820","count":2},{"id":"GO:0055114","count":2},{"id":"GO:1903999","count":1},{"id":"GO:0046381","count":1},{"id":"GO:0034414","count":1}]},{"hash":"926705917551337408","title":"Sugar Metabolism and Related Pathways","description":"The top terms are largely centered on carbohydrate metabolism and related redox/energy processes (sorbitol and fructose metabolism, xylulose-5-phosphate biosynthesis, pyruvate fermentation, NADH oxidation), with a few outliers (lipopolysaccharide response, lignin/retinol metabolism). This suggests a functional theme around sugar metabolism and general metabolic processing rather than a single, cohesive pathway, hence the chosen label. ","confidence":"Medium","size":9,"edges":22,"triangles":24,"max_degree":7,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0032496","count":7},{"id":"GO:0043458","count":6},{"id":"GO:0046294","count":6},{"id":"GO:0006116","count":6}]},{"hash":"490825960193728480","title":"DNA Damage Response and Cell Cycle Signaling","description":"The cluster centers on DNA replication unwinding, SOS response, and repair-related nucleic acid processing, with mitotic cell cycle and kinase signaling indicating cell-cycle control under stress; some terms reflect broader developmental and stress responses, but the dominant theme is genome maintenance linked to cell-cycle regulation.","confidence":"Medium","size":9,"edges":16,"triangles":7,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048568","count":4},{"id":"GO:0032508","count":4},{"id":"GO:0009432","count":4},{"id":"GO:0006268","count":4},{"id":"GO:0090305","count":4}]},{"hash":"64390468274405632","title":"Unknown","description":"The terms span multiple kingdoms and disparate processes (mitotic spindle/cytoskeleton, neuronal signaling, Schwann cell development, calcium sensing and calcineurin\u2013NFAT signaling, fungal sporulation, plant ABA signaling, cardiac stress response, and phosphorylation regulation), with no single cohesive function tying them together. Therefore there isn\u2019t a confident, representative label other than Unknown.","confidence":"","size":9,"edges":30,"triangles":51,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903087","count":7},{"id":"GO:0007020","count":7},{"id":"GO:0060079","count":6},{"id":"GO:0014044","count":6},{"id":"GO:0005513","count":5}]},{"hash":"301050584799977160","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048568","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0042273","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0000463","count":2}]},{"hash":"1895777632062495412","title":"Angiogenesis and ECM Remodeling","description":"The top GO terms cluster around vascular development and extracellular matrix remodeling, including angiogenesis, endothelial cell migration, integrin signaling, and positive regulation of metallopeptidase activity, along with hyaluronan metabolism and ECM-related processes. Blood coagulation also ties into vascular function, supporting a cohesive theme of blood vessel formation and matrix remodeling. A few outlier terms (e.g., dopaminergic synaptic transmission) are present but do not override the predominant angiogenesis/ECM signal.","confidence":"Medium","size":9,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007100","count":2},{"id":"GO:0030212","count":2},{"id":"GO:0007596","count":2},{"id":"GO:1905050","count":2},{"id":"GO:0007229","count":2}]},{"hash":"2213225683862622404","title":"Ribosome biogenesis and translation","description":"Top GO terms cluster around ribosome function\u2014maturation of LSU- and 5.8S rRNA, ribosome biogenesis, formation of translation preinitiation complex, and translation reinitiation\u2014along with RNA guanine-N7-methylation. This points to a shared role in ribosome assembly and translation initiation. Other terms such as response to antibiotic, neuron apoptotic process, and cell population proliferation appear less central, likely reflecting broader cellular stress or developmental contexts rather than defining this group. Overall, the proteins are best characterized as involved in ribosome biogenesis and translation.","confidence":"High","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0051402","count":2},{"id":"GO:0000466","count":2}]},{"hash":"1406273576075728","title":"Innate Immune Signaling and Leukocyte Trafficking","description":"The most represented GO terms are immune-related: complement activation via the lectin pathway, stimulatory C-type lectin receptor signaling, and leukocyte tethering or rolling, along with basophil activation and negative regulation of NK cell chemotaxis. These indicate a cluster centered on innate immune sensing and recruitment of leukocytes. While there are also developmental terms such as cartilage condensation and lymph vessel morphogenesis, the core signal is immune signaling and leukocyte interaction.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":3},{"id":"GO:0071901","count":2},{"id":"GO:2000502","count":2},{"id":"GO:0071226","count":2},{"id":"GO:0045575","count":2}]},{"hash":"435242300997532692","title":"Biosynthesis and central metabolism","description":"The top GO terms are dominated by biosynthetic and central carbon metabolism processes (pyruvate biosynthesis, gluconeogenesis, fatty acid and biotin biosynthesis, protoporphyrinogen IX biosynthesis, and aminoadipic acid pathway), suggesting the cluster groups proteins involved in general metabolism and biosynthesis rather than a single signaling function. The Notch signaling term is present but appears incidental to the main metabolic theme.","confidence":"Medium","size":9,"edges":32,"triangles":62,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0019878","count":3},{"id":"GO:0007219","count":3},{"id":"GO:0042853","count":3},{"id":"GO:0097053","count":3},{"id":"GO:0042866","count":3}]},{"hash":"1874218604783156281","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0000278","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0051301","count":2}]},{"hash":"711691035875550665","title":"Neural development with dendrite morphogenesis","description":"This cluster shows strong signals for nervous system development, dendrite morphogenesis, and excitatory synaptic activity (e.g., excitatory postsynaptic potential), indicating a neural development and synaptic maturation theme. The mitotic cell cycle and spindle assembly terms suggest proliferative states in neural progenitors, but the neural development and dendrite/synaptic terms dominate, supporting a representative label focused on neural development.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0007399","count":4},{"id":"GO:0090307","count":4},{"id":"GO:0048813","count":4}]},{"hash":"2037728556873113165","title":"Cardiac and skeletal muscle contraction and growth","description":"These proteins show strong signals for muscle-related functions: cardiac muscle contraction and diaphragm contraction indicate heart and skeletal muscle activity, while neuromuscular regulation and growth-related terms suggest development and remodeling. Wound healing and multicellular growth terms also align with tissue repair and growth around muscle tissues, though one defense-related term is less fitting. Overall, the cluster represents muscle development, function, and repair processes.","confidence":"Medium","size":9,"edges":25,"triangles":32,"max_degree":8,"top_function":"wound healing","top_go_terms":[{"id":"GO:0042060","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0050885","count":3}]},{"hash":"1092878101433965840","title":"Hormone Metabolism and Development","description":"These proteins show enrichment in several hormone- and development-related GO terms, including retinoic acid catabolic process, prostaglandin biosynthesis, androgen metabolism, vitamin D response, and aldosterone-regulated blood volume. While some terms touch on metal or immune responses, the dominant theme is hormonal metabolism and related developmental regulation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034653","count":6},{"id":"GO:0070989","count":6},{"id":"GO:0001516","count":6},{"id":"GO:0060065","count":6},{"id":"GO:0071280","count":6}]},{"hash":"1591103025825582321","title":"Protein quality control and trafficking","description":"The cluster\u2019s top GO terms cluster strongly around protein quality control and trafficking: nuclear export regulation, misfolded protein transport, post-translational targeting to membranes, and ubiquitin-proteasome\u2013mediated quality control, with additional links to regulation of protein kinase activity. These collectively point to maintaining protein homeostasis through folding, degradation, and proper localization, with a few developmental signaling terms as supporting context. ","confidence":"High","size":9,"edges":27,"triangles":41,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001707","count":5},{"id":"GO:0090084","count":4},{"id":"GO:0071374","count":4},{"id":"GO:0045454","count":4},{"id":"GO:0006469","count":4}]},{"hash":"1736370084110702096","title":"Hormone Metabolism and Signaling","description":"The top GO terms cluster around hormone-related processes (prostaglandin biosynthesis, androgen metabolism, vitamin D response, and aldosterone-regulated blood volume), with related roles in retinoic acid and uterus development. This suggests an endocrine/metabolic theme, despite a few less-connected terms, justifying a label centered on hormone signaling and metabolism.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900087","count":5},{"id":"GO:0034653","count":4},{"id":"GO:0070989","count":4},{"id":"GO:0001516","count":4},{"id":"GO:0060065","count":4}]},{"hash":"1197735907047869060","title":"Regulatory signaling and developmental proteins","description":"This cluster features GO terms centered on regulation of signaling processes (GTPase activity, serine/threonine kinase activity, protein autophosphorylation) and broader developmental contexts (neuron projection development, lens fiber cell differentiation, mitotic cell cycle), along with accompanying regulatory processes (mRNA transport, protein homooligomerization). The varied but cohesive theme is proteins involved in modulating signaling pathways and developmental programs, rather than a single, specific pathway. Confidence: Medium","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071456","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0070306","count":3}]},{"hash":"590770403364053210","title":"Developmental transcription regulators","description":"The top GO terms point to broad developmental roles across multiple tissues (midbrain, brain, retina, pituitary, spleen, digits, rhombomere), with an additional hint of transcriptional regulation via RNA Pol II. This pattern suggests a set of proteins that regulate transcription during embryonic development rather than a single tissue-specific function.","confidence":"Medium","size":9,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0030901","count":4},{"id":"GO:0021983","count":4},{"id":"GO:0007338","count":4},{"id":"GO:0008584","count":4}]},{"hash":"72856164484859109","title":"Cerebellar development and neural differentiation","description":"The top terms center on cerebellar development and neural differentiation, including cerebellar cortex formation, Bergmann glial cell differentiation, and regulation of axon regeneration. While some terms relate to cell cycle control and broader signaling (kinetochore localization, CDK activity, insulin signaling), the converging neural-development signals suggest this theme is representative of the cluster. ","confidence":"Medium","size":9,"edges":31,"triangles":55,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034501","count":7},{"id":"GO:0045736","count":7},{"id":"GO:0008285","count":6},{"id":"GO:0060020","count":6},{"id":"GO:0008286","count":6}]},{"hash":"948597111680054500","title":"Ribosome biogenesis and translation","description":"The predominant GO terms are translation-related: translation, ribosome biogenesis, translational termination, ribosome disassembly, and tRNA modification, pointing to proteins involved in ribosome function and protein synthesis. Additional terms such as antibiotic response and cell cycle appear but are less central, while viral replication and chromatin-related regulation are peripheral. Thus the cluster is best described as ribosome/translation machinery.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0042254","count":3},{"id":"GO:0006415","count":2},{"id":"GO:0032790","count":2},{"id":"GO:0046677","count":2}]},{"hash":"1728191352782165661","title":"Tissue differentiation and morphogenesis signaling","description":"This cluster shows repeated enrichment for terms related to differentiation (keratinocytes, hair cycle, brown fat) and tissue morphogenesis (aorta, endothelium, smooth muscle), plus Notch processing\u2014pointing to broad involvement in developmental signaling across multiple tissues rather than a single tissue. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0021693","count":9},{"id":"GO:0061419","count":9},{"id":"GO:1903588","count":9},{"id":"GO:0090336","count":9},{"id":"GO:0042633","count":9}]},{"hash":"2130209419941883366","title":"Vertebrate Embryonic Morphogenesis","description":"This cluster centers on embryonic development and organ morphogenesis across multiple tissues (heart, eye, hindlimb, inner ear, placenta) and related processes, with terms like in utero development and neuron maturation supporting a vertebrate embryogenesis theme. The cohesive theme is embryonic organ formation and patterning.","confidence":"High","size":9,"edges":6,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042551","count":5},{"id":"GO:0001701","count":5},{"id":"GO:0048752","count":5},{"id":"GO:0001890","count":4},{"id":"GO:0043433","count":4}]},{"hash":"1810757624029299523","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":8},{"id":"GO:0031047","count":6},{"id":"GO:0048026","count":6},{"id":"GO:0000398","count":5},{"id":"GO:0016120","count":4}]},{"hash":"1545228882542318014","title":"Secretory Trafficking and Proteoglycan Metabolism","description":"The top terms cluster around secretion and trafficking (ER exit, lysosomal enzyme secretion, surface localization) and extracellular matrix components (proteoglycan metabolism). A few terms reference filamentous/fungal growth under nutrient limitation, which often involves surface remodeling and secretory changes. Together these point to a theme of secretory pathway activity tied to cell surface and ECM interactions.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070863","count":1},{"id":"GO:0033299","count":1},{"id":"GO:2000010","count":1},{"id":"GO:0001403","count":1},{"id":"GO:0007124","count":1}]},{"hash":"2271671877295404751","title":"Developmental Transcription and MAPK Signaling","description":"This cluster centers on DNA-templated transcription and a p38 MAPK signaling cascade, with additional tissue development and differentiation terms spanning mammary gland, heart, Leydig cells, placenta, and fat tissue, plus cardiac morphogenesis. Together these terms point to a set of proteins involved in regulating gene expression during development and differentiation, modulated by MAPK signaling. The mix of transcriptional control and broad developmental processes suggests a cohesive theme rather than a single tissue-specific function.","confidence":"High","size":9,"edges":19,"triangles":25,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0060749","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0033327","count":6},{"id":"GO:0001890","count":5}]},{"hash":"1602682976029635670","title":"Angiogenesis and neural development with ECM remodeling","description":"The cluster shows enrichment for vascular/neuronal development terms (sprouting angiogenesis, VEGF receptor signaling, axon guidance) together with ECM organization and cell-matrix adhesion, suggesting coordinated roles in vessel formation and neural patterning via ECM interactions, even without direct protein-protein edges observed here.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0007605","count":5},{"id":"GO:0002042","count":4},{"id":"GO:0048745","count":4},{"id":"GO:0048010","count":3},{"id":"GO:0007413","count":3}]},{"hash":"1058016391092229600","title":"Neural Sensory Perception and Dopaminergic Signaling","description":"The terms cluster around nervous system function and sensory processing\u2014pain and visual perception, visual learning, dopaminergic synaptic transmission, and cocaine-related behavior\u2014with supporting signaling pathways such as ERK and prostaglandin responses. Although angiogenesis and heart development appear, the dominant pattern supports neuronal signaling and sensory processing modulated by dopamine as the core theme.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0001963","count":6},{"id":"GO:0007601","count":6},{"id":"GO:0010759","count":6},{"id":"GO:0048148","count":6}]},{"hash":"1827602866400306407","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":2},{"id":"GO:0043050","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0000398","count":1},{"id":"GO:0080188","count":1}]},{"hash":"784105483289462109","title":"Broad Membrane Transporters for Ions and Nutrients","description":"This cluster is dominated by GO terms describing transmembrane transport across various substrates\u2014nitrate, sodium, potassium, phosphate, sugars, vitamins, and related compounds\u2014suggesting a core function as membrane transport proteins that move diverse nutrients and ions. The repeated emphasis on transport across membranes, rather than catalytic enzymatic activity, supports a transporter-centric interpretation for these proteins.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":2},{"id":"GO:0015739","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0006004","count":2},{"id":"GO:0015706","count":2}]},{"hash":"145238579916044317","title":"Embryonic Patterning and Organogenesis","description":"The GO terms point to embryonic development and tissue/morphogenesis across diverse organs (including facial structures, brain patterning, reproductive and renal systems, and limbs) and to signaling regulation (Wnt) and cytoskeletal/GTPase activity, suggesting a cohesive developmental program governing organ formation.","confidence":"Medium","size":9,"edges":33,"triangles":64,"max_degree":8,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0061198","count":4},{"id":"GO:0006607","count":4},{"id":"GO:0022006","count":4},{"id":"GO:0086019","count":4},{"id":"GO:0035293","count":4}]},{"hash":"1061237596678642807","title":"Developmental patterning and organogenesis","description":"This cluster shows a mix of GO terms tied to developmental processes across multiple tissues (e.g., papilla formation, cranial ganglion and oviduct development, renal vesicle formation) plus chromatin remodeling and nucleus import activities, suggesting a broad role in embryonic development and tissue formation rather than a single organ-specific function. ","confidence":"Medium","size":9,"edges":32,"triangles":59,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0061198","count":3},{"id":"GO:0006607","count":3},{"id":"GO:0022006","count":3},{"id":"GO:0035293","count":3},{"id":"GO:0086019","count":3}]},{"hash":"326783029932662773","title":"Translation Machinery and Cell Cycle Signals","description":"The predominant GO terms point to various stages of protein synthesis (translation, translational elongation and termination, cytoplasmic translation) with a couple of mitosis-related cohesion terms, suggesting a core focus on translation with some cell-cycle associations.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007064","count":1},{"id":"GO:0044376","count":1},{"id":"GO:0045901","count":1},{"id":"GO:0006412","count":1},{"id":"GO:2000767","count":1}]},{"hash":"1007647139614909105","title":"Gene regulation and cytokinesis control","description":"The cluster centers on transcriptional regulation and chromatin-associated processes (DNA-templated transcription, histone methylation regulation) with supporting roles in signaling (TORC1, TGF-beta) and protein turnover (SCF-dependent ubiquitin-mediated proteolysis). Also present are cues related to cell division control (negative regulation of cytokinesis) and stress responses (hypoxia), suggesting a cohesive theme of coordinating gene expression with cell-cycle progression under signaling and stress conditions.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0071560","count":3},{"id":"GO:0038202","count":3},{"id":"GO:2001162","count":2},{"id":"GO:0000920","count":2}]},{"hash":"1117597606925183047","title":"Unknown","description":"The GO terms indicate broad developmental and reproductive processes (embryogenesis, axis specification, polyspermy prevention, pharyngeal pumping) plus general protein regulation (ubiquitination, proteolysis) but do not converge on a single, cohesive function for the cluster.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0007313","count":2},{"id":"GO:0043050","count":2},{"id":"GO:0035124","count":2}]},{"hash":"951101091438024312","title":"Unknown","description":"The terms show a scattered mix of developmental processes across various tissues (intestinal, skeletal, sexual characteristics) plus unrelated terms such as viral process and meiotic division, and even obsolete biosynthetic terms, providing no cohesive shared function for the protein cluster. Therefore, there is no clear theme to assign a specific, concise label.","confidence":"","size":9,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007143","count":2},{"id":"GO:0060576","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0032092","count":1}]},{"hash":"1513572203290878040","title":"Complement and proteolysis-driven innate immunity","description":"The proteins are enriched for complement activation (lectin pathway) and proteolytic processes (fibrinolysis), pointing to innate immune and coagulation-related functions. Additional terms involve lectin receptor signaling and basophil/NK cell\u2013related immune modulation, suggesting a cluster of innate immune mediators linking coagulation and defense against fungal-origin stimuli.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0042730","count":2},{"id":"GO:0001502","count":1},{"id":"GO:2000502","count":1}]},{"hash":"2253757665214861476","title":"Cellular stress response to oxidants, xenobiotics, hypoxia","description":"The cluster centers on detoxification of oxidants and responses to xenobiotics (oxidative stress and chemical challenges), with additional hints of hypoxic response and innate immune signaling via LPS. Calcium signaling and nuclear import appear as downstream regulatory features in stress responses. Together, these terms point to a cohesive cellular stress response to oxidative and chemical stress, with an immune/anticipatory regulation component.","confidence":"Medium","size":9,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0071277","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0007205","count":1}]},{"hash":"460359831419779331","title":"Coagulation and complement activation","description":"The cluster is dominated by GO terms related to immune-coagulation processes: complement activation via lectin and classical pathways, plasminogen activation and fibrinolysis, and platelet activation, suggesting a coherent theme of hemostasis and immune response; a couple of brain-development and behavioral terms appear as outliers. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0031639","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0006958","count":2}]},{"hash":"762555985487876941","title":"Unknown","description":"The nine proteins have GO terms spanning endothelial barrier establishment, tight junction assembly, neuronal development, synaptic plasticity, and related signaling, with little overlap suggesting a cohesive function. Because there is no clear common theme or interaction pattern among the terms, a robust single-function label cannot be inferred.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061028","count":1},{"id":"GO:0034115","count":1},{"id":"GO:0007605","count":1},{"id":"GO:0070830","count":1},{"id":"GO:0090038","count":1}]},{"hash":"661033507215241449","title":"Neural development and synapse maturation with ECM remodeling","description":"This cluster is dominated by GO terms linked to neural development and synaptic processes (regulation of neuronal synaptic plasticity, cerebellar Purkinje cell layer development, synapse maturation), and reinforced by extracellular matrix interactions (hyaluronan metabolic process, calcium-independent cell-matrix adhesion). While there are also immune/coagulation terms present, the core signal points to neural development and synaptic organization alongside ECM remodeling, justifying this label.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":4},{"id":"GO:0070208","count":4},{"id":"GO:0048168","count":3},{"id":"GO:0021680","count":3},{"id":"GO:0060074","count":3}]},{"hash":"1713887537408501441","title":"Unknown","description":"The GO terms in this cluster are scattered: ribosome biogenesis and negative regulation of RNA biosynthesis hint at RNA production-related activity, but there are also terms related to GTPase activity regulation, spermatogenesis, and suppression of viral release, plus obsolete terms and no network connectivity. There isn\u2019t a clear, cohesive function tying all eight proteins together, so a specific label is not justifiable. ","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0042254","count":2},{"id":"GO:1900226","count":1}]},{"hash":"766297062315432411","title":"Cardiac calcium signaling and contraction regulation","description":"The cluster\u2019s top GO terms cluster around heart development, regulation of cardiac muscle contraction, activation of adenylate cyclase, calcium release into the cytosol, and protein phosphorylation. Together these point to calcium-dependent signaling pathways that control cardiac excitation-contraction, with some non-cardiac terms like visual perception and pain likely incidental annotations.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006468","count":7},{"id":"GO:0007601","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0043547","count":6}]},{"hash":"1968651057378026008","title":"Nuclear transport and chromatin assembly","description":"The top GO terms are dominated by nuclear processes: import into the nucleus (NLS-bearing proteins), DNA replication-dependent chromatin assembly, mitotic nuclear membrane reassembly, and meiotic nuclear division, plus nuclear transcription by RNA polymerase III and regulation of desumoylation. While there are a few more general terms, the overall pattern points to nuclear functions and cell-cycle\u2013related regulation, suggesting the cluster mainly comprises nuclear transport and chromatin/cell-cycle factors.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071230","count":2},{"id":"GO:0006607","count":1},{"id":"GO:0007084","count":1},{"id":"GO:0006335","count":1},{"id":"GO:0097711","count":1}]},{"hash":"1017033962439862332","title":"Unknown","description":"The GO terms are highly diverse and only appear once each, with no clear shared process or pathway linking them (ranging from telomere maintenance and proteolysis to tRNA modification, glycosylation, LPS biosynthesis, exocytosis, and ascorbate biosynthesis), so there isn\u2019t a coherent theme to name the cluster. ","confidence":"","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000722","count":1},{"id":"GO:0006508","count":1},{"id":"GO:0072670","count":1},{"id":"GO:0046944","count":1},{"id":"GO:0016311","count":1}]},{"hash":"2053593436453038996","title":"Unknown","description":"The top terms span diverse and seemingly unrelated biological contexts (immune signaling, nervous system and muscle development, renal ion transport, plant glucosinolate metabolism) and include both ubiquitin-related protein turnover and protein oligomerization. There isn\u2019t a clear, single pathway or function tying these proteins together, so a cohesive label isn\u2019t apparent.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":5},{"id":"GO:0050853","count":5},{"id":"GO:0007399","count":4},{"id":"GO:0031397","count":4},{"id":"GO:0036268","count":4}]},{"hash":"1893114269394359723","title":"Vesicle trafficking and cytoskeleton dynamics","description":"The top terms cluster around intracellular transport between organelles (ER-Golgi, Golgi-vacuole, endosome-to-Golgi, anterograde/retrograde transport) and actin cytoskeleton remodeling (actin filament depolymerization), indicating a coherent theme of vesicle movement linked to cytoskeletal dynamics; some neural development/behavior terms may reflect CNS-specific roles of these pathways. This label captures the primary shared function of the cluster.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0090307","count":2},{"id":"GO:0030042","count":2},{"id":"GO:0021691","count":2},{"id":"GO:0009615","count":2}]},{"hash":"2228481187175105749","title":"Negative Regulation of Signaling and Synaptic Function","description":"Proteins in this cluster repeatedly appear under terms describing negative regulation of signaling pathways (MAPK/ERK cascades, PI3K/AKT, T cell receptor signaling) and neural synaptic processes (postsynaptic density assembly, synaptic vesicle clustering, habituation). This suggests a cohesive theme of regulators that dampen signaling and modulate synaptic organization, rather than a single pathway or process.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0050860","count":6},{"id":"GO:0000200","count":6},{"id":"GO:0070373","count":6},{"id":"GO:2000808","count":5},{"id":"GO:0051895","count":5}]},{"hash":"1817318516110659041","title":"Pentose metabolism and cofactor biosynthesis","description":"The terms cluster around pentose metabolism (pentose catabolic process and pentose-phosphate shunt) and the biosynthesis of cofactors (molybdopterin, biotin, menaquinone) as well as RNA-related biosynthesis/modification (tRNA queuosine biosynthesis and tRNA methylation), indicating a broader metabolic module focused on sugar metabolism and essential cofactors. It\u2019s a cohesive enough theme to name the cluster, though the tRNA modification terms are a bit peripheral to the core metabolic signals. Confidence: Medium","confidence":"","size":8,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019323","count":1},{"id":"GO:0044262","count":1},{"id":"GO:0009052","count":1},{"id":"GO:0006098","count":1},{"id":"GO:0006777","count":1}]},{"hash":"868364704755748796","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":25,"triangles":40,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0090503","count":3},{"id":"GO:0016120","count":2},{"id":"GO:0048024","count":2},{"id":"GO:0070935","count":2}]},{"hash":"1630065334597785617","title":"Regulation of signaling and transcription","description":"The Top Terms show a mix of signaling-related processes (response to vitamin D, prostaglandin biosynthesis, regulation of calcium channels) and gene expression control (regulation of RNA polymerase II transcription, methylation-related regulation). This suggests a cohesive theme around cellular signaling and transcriptional regulation rather than a single metabolite pathway, hence a label reflecting regulatory/signaling focus.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903071","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0001516","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0010637","count":2}]},{"hash":"1755215257569548601","title":"Unknown","description":"The GO terms span immune signaling (TNF and IL-12 production), xenobiotic response, coagulation, reproductive development, neuronal migration, and behavior, with little overlap suggesting a common biological process. No edges or cohesive functional group emerges from the terms; thus I cannot assign a specific, representative label beyond Unknown.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010513","count":2},{"id":"GO:0032720","count":1},{"id":"GO:0048609","count":1},{"id":"GO:0071502","count":1},{"id":"GO:0042755","count":1}]},{"hash":"2003627791668288683","title":"Large subunit ribosome biogenesis and export","description":"The Top Terms are strongly centered on ribosome biogenesis, especially the large subunit (LSU) pathway, including LSU biogenesis, preribosome assembly, and export of LSU from the nucleus, as well as LSU-rRNA maturation and related translation processes. A few cell-cycle terms appear but the dominant signal is ribosome assembly/export, suggesting the cluster represents LSU production and maturation activity.","confidence":"High","size":8,"edges":25,"triangles":41,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0042273","count":3},{"id":"GO:0051301","count":2},{"id":"GO:1902626","count":2},{"id":"GO:0000055","count":2}]},{"hash":"1227999820825941962","title":"T cell and dendritic cell activation via NF-kB","description":"The dominant terms point to NF-kappaB signaling driving T cell activation and dendritic cell differentiation, supported by related immune-responses (virus exposure) and cellular stress signals; a few terms about myoblast and neuron development are peripheral.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":2},{"id":"GO:0098586","count":1},{"id":"GO:0042493","count":1},{"id":"GO:2001190","count":1},{"id":"GO:0071333","count":1}]},{"hash":"1505055932904624537","title":"FGF-MAPK signaling and angiogenesis","description":"The cluster centers on positive regulation of the ERK1/ERK2 cascade and angiogenesis, with multiple terms tied to FGFR signaling, endothelial chemotaxis to FGF, and related developmental processes, suggesting a coherent theme of growth-factor-driven MAPK signaling promoting vascular development. Exocytosis and cell-surface localization terms fit with membrane- and trafficking-related aspects of endothelial signaling. ","confidence":"High","size":8,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":3},{"id":"GO:0001525","count":2},{"id":"GO:0048538","count":2},{"id":"GO:0034394","count":2},{"id":"GO:0045921","count":2}]},{"hash":"293423313404246519","title":"Chromatin modification and heterochromatin regulation","description":"The cluster shows strong enrichment for chromatin-related processes, including histone H4 acetylation, N-terminal peptidyl-serine acetylation, and spermine acetylation, as well as centromeric cohesion and subtelomeric heterochromatin formation, all pointing to regulation of chromatin structure and gene expression. Some GO terms like mycothiol biosynthesis and angiogenesis appear as outliers or annotation noise, but the core pattern centers on chromatin modification and heterochromatin organization.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0010125","count":7},{"id":"GO:0001525","count":7},{"id":"GO:0046208","count":7},{"id":"GO:0071962","count":7},{"id":"GO:0017198","count":7}]},{"hash":"1789397231362202628","title":"Innate immune signaling and leukocyte recruitment","description":"The top GO terms cluster around innate immune recognition and signaling (C-type lectin receptor signaling, lectin pathway complement activation, response to fungal origin) alongside leukocyte trafficking features (basophil activation, NK cell chemotaxis regulation, leukocyte tethering/rolling, and regulation of adhesion molecule production) and lymphatic vessel morphogenesis. This suggests a coherent module coordinating pathogen sensing with immune cell recruitment and vascular interactions, even though a few terms (like cartilage condensation) are more context-dependent. Overall, the cluster appears to represent innate immune activation coupled with leukocyte trafficking.","confidence":"Medium","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":8},{"id":"GO:2000502","count":8},{"id":"GO:0071226","count":8},{"id":"GO:0045575","count":8},{"id":"GO:0090403","count":8}]},{"hash":"542094805347406795","title":"Angiogenesis and Growth Factor Signaling","description":"The top GO terms cluster around angiogenesis and receptor-mediated signaling pathways driven by growth factors (VEGF/PDGF/FGF) with downstream STAT activation, indicating a coherent theme of vascular development and growth factor\u2013driven signaling; a few terms are peripheral (sodium transport, pigment cell migration), but the dominant signal is growth factor\u2013regulated angiogenesis and proliferation.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010765","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0050853","count":3},{"id":"GO:0060484","count":3},{"id":"GO:1902178","count":3}]},{"hash":"2280811674191286387","title":"Unknown","description":"The top terms are highly diverse, ranging from ethanol response and erythrocyte maturation to NF-kappaB signaling, histone ubiquitination, brain structure, Rap signaling, RNA localization, transcription elongation, and even plant hormone biosynthesis. This lack of a common, cohesive biological theme across the cluster suggests there is no meaningful shared function to label, so the cluster is Unknown with no confidence.","confidence":"","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045471","count":2},{"id":"GO:0043249","count":2},{"id":"GO:0007249","count":1},{"id":"GO:0070535","count":1},{"id":"GO:0021693","count":1}]},{"hash":"1852221599390615039","title":"Embryonic development and stress signaling","description":"This cluster of proteins is enriched for developmental terms such as angiogenesis, multicellular organism development, forebrain development, and neural tube closure, which suggests a core theme around embryonic morphogenesis. Additional terms like G2/M transition and positive regulation of peptidyl-threonine phosphorylation reflect cell-cycle and signaling control relevant to development. The presence of cellular responses to lipopolysaccharide and ER-stress\u2013related apoptotic signaling indicates stress-response connections layered onto developmental pathways; the abscisic acid-activated signaling pathway further points to plant-stress signaling contexts. Overall, the dominant theme is developmental/morphogenetic signaling with associated stress responses. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0009738","count":2},{"id":"GO:0000086","count":2},{"id":"GO:0001843","count":2}]},{"hash":"1397958767667593517","title":"Nucleobase Transporters","description":"GO terms show diverse nucleobase/purine transport across the plasma membrane (xanthine, urate, adenine, hypoxanthine, guanine, uracil, etc.), indicating a transporter-facing cluster; the extra GTPase regulation and Ca2+ release terms seem ancillary signaling-related annotations.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0051209","count":2},{"id":"GO:0042906","count":1},{"id":"GO:0015747","count":1},{"id":"GO:1903825","count":1}]},{"hash":"992009084190685128","title":"Cell Fate Specification and Differentiation","description":"This cluster is dominated by GO terms about cell fate determination and differentiation across tissues (cone cell fate, wing cell fate, spermatid differentiation) and regulatory interactions (negative regulation of NK cell activation). While there are additional terms pointing to protein processing and organellar/homeostatic functions (unfolded protein response, ER-to-cytosol proteolysis, vacuolar processes, copper homeostasis, energy metabolism), the strongest and most coherent signal is differentiation and fate specification across diverse cell types.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032815","count":2},{"id":"GO:0042676","count":2},{"id":"GO:0034620","count":2},{"id":"GO:0038005","count":2},{"id":"GO:1904211","count":2}]},{"hash":"2192079364535897748","title":"Neural development and signaling pathways","description":"The top terms highlight neural signaling and development, especially Roundabout and Smoothened pathways, nervous system development, and learning, suggesting proteins involved in neural development signaling. Other terms like epithelial polarity, kidney development, and T cell signaling imply broader developmental roles.","confidence":"Medium","size":7,"edges":12,"triangles":6,"max_degree":5,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0035385","count":5},{"id":"GO:0007399","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0033138","count":4}]},{"hash":"557976905776907124","title":"Neural development and synaptic plasticity","description":"The top GO terms center on nervous system and brain development (forebrain development, axonogenesis, Schwann cell development, heart development but not core) along with synaptic signaling and plasticity (long-term potentiation, excitatory postsynaptic potential, visual perception). This combination points to a cluster focused on neural development and synaptic function/plasticity, despite some general developmental terms. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0007409","count":5},{"id":"GO:0060079","count":4},{"id":"GO:0007601","count":4}]},{"hash":"1454393975830421223","title":"Mitochondrial Energy Metabolism","description":"The cluster is dominated by metabolic processes tied to mitochondrial energy production, including the TCA cycle, 2-oxoglutarate metabolism, glycolysis, and proton-motive force-driven ATP synthesis. While a few terms point to development (angiogenesis, endothelial migration, osteoblast differentiation) these appear secondary to the central metabolic theme, suggesting the proteins collectively function in cellular energy generation. ","confidence":"Medium","size":7,"edges":16,"triangles":16,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":4},{"id":"GO:0006103","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0006814","count":2},{"id":"GO:0006096","count":2}]},{"hash":"1076913321833506658","title":"Phosphorylation-driven signaling in development","description":"Top GO terms center on protein phosphorylation (GO:0006468) and regulation of phosphorylation (GO:0010800), spanning mitotic control (G2/M transition, mitotic cell cycle) to development-related processes (angiogenesis, myoblast fusion) and sensory/neural functions (visual perception, excitatory postsynaptic potential). The diversity suggests a common theme of phosphorylation-based signaling modulating multiple cellular and developmental pathways, rather than a single canonical pathway. ABA signaling appears as a distant annotation rather than a unifying feature. Confidence: Medium","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0009738","count":5},{"id":"GO:0060079","count":5},{"id":"GO:0010800","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0000086","count":5}]},{"hash":"559936986489640877","title":"Endosome-to-vacuole transport and MVB sorting","description":"The top GO terms cluster around endocytosis, the multivesicular body (MVB) sorting pathway, and transport steps between Golgi, endosomes, and vacuoles, indicating a focused role in endocytic vesicle trafficking and vacuolar/MVB sorting. Some terms appear unrelated (e.g., certain developmental or reproductive terms) but the core signals strongly point to endosomal sorting and vacuolar targeting.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":4},{"id":"GO:0071985","count":4},{"id":"GO:0006895","count":4},{"id":"GO:0034498","count":4},{"id":"GO:0015032","count":3}]},{"hash":"464464826806288964","title":"Eye morphogenesis and retinal axon guidance","description":"This cluster is dominated by terms related to vertebrate eye development, including camera-type eye morphogenesis and retinal ganglion cell axon guidance, with supporting signals from ephrin and integrin-mediated adhesion pathways and neural crest\u2013related processes, suggesting a cohesive theme of eye formation and retinal connectivity in development.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014028","count":2},{"id":"GO:0071372","count":2},{"id":"GO:0048013","count":2},{"id":"GO:0031290","count":2},{"id":"GO:1904322","count":2}]},{"hash":"1225053874437347606","title":"Ribosome Biogenesis and Translation","description":"The top terms are dominated by ribosome biogenesis (GO:0042254) with 3 proteins and translation (GO:0006412) with 2 proteins, pointing to a core function in ribosome assembly and protein synthesis. A few other terms (cell wall and lipid biosynthesis) occur only once and are likely incidental or due to multifunctional annotations. The cluster shows no edge connections, but the strongest, repeated GO signals center on ribosomal processes, supporting this label.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0071555","count":1},{"id":"GO:0009245","count":1},{"id":"GO:0009272","count":1}]},{"hash":"596005917212377769","title":"Cardiovascular and renal organogenesis with cell adhesion","description":"The terms cluster around embryonic development of vascular and cardiac structures (dorsal aorta morphogenesis, endocardial cushion formation, sprouting angiogenesis) and nephrogenesis (metanephric development), with emphasis on cell-matrix and cell-cell adhesion. While some endocrine terms appear, the dominant theme is organogenesis driven by adhesion-mediated morphogenesis in cardiovascular and renal contexts.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":6},{"id":"GO:0097211","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0090050","count":4},{"id":"GO:0003273","count":4}]},{"hash":"1443515877132701845","title":"Neuroimmune Regulation and Coagulation","description":"The cluster includes immune-related terms (blood coagulation, TNF and IL-12 production, CD8 T cell differentiation) and neural processes (GABAergic interneuron migration, modulation of glutamatergic transmission), plus stress and behavioral responses (temperature stimulus, xenobiotic response, eating behavior). This pattern suggests a module where immune signaling intersects neural function and coagulation/hemostasis, rather than a single isolated pathway.","confidence":"Medium","size":7,"edges":19,"triangles":25,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":4},{"id":"GO:0032720","count":3},{"id":"GO:0048609","count":3},{"id":"GO:0071502","count":3},{"id":"GO:0042755","count":3}]},{"hash":"783003048753589287","title":"Neural development and synapse organization","description":"This cluster is dominated by terms tied to nervous system development, corpus callosum development, dendrite growth, synapse assembly, and clustering of voltage-gated sodium channels, suggesting a set of proteins involved in neural development and synaptic architecture. A few terms related to nephric duct morphogenesis or endodermal differentiation and an obsolete APP-related term appear less connected to the core neural theme, likely reflecting broad or overlapping annotations.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":7},{"id":"GO:0045162","count":7},{"id":"GO:0050773","count":7},{"id":"GO:1902960","count":7},{"id":"GO:0007399","count":7}]},{"hash":"1082072905871013821","title":"Protein Quality Control and Trafficking","description":"The proteins in this cluster show GO terms dominated by proteostasis and intracellular trafficking: nuclear proteostasis via the ubiquitin-proteasome system, handling of misfolded proteins, export regulation from the nucleus, and post-translational targeting to membranes. Redox homeostasis and occasional developmental signaling terms appear as ancillary connections, but the central theme is protein quality control and intracellular localization/trafficking.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0090084","count":1},{"id":"GO:0071374","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0006469","count":1},{"id":"GO:0046825","count":1}]},{"hash":"829159365581805560","title":"Membrane Transporters","description":"Top GO terms indicate multiple transmembrane transport activities across the plasma membrane, including selenite, sialic acid, urate, potassium, and xenobiotic transport, as well as neurotransmitter loading into synaptic vesicles. Together these suggest a cluster enriched for membrane transporter proteins with diverse substrate specificities; a few obsolete terms do not alter this overarching theme. ","confidence":"High","size":7,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0097080","count":2},{"id":"GO:0015739","count":2},{"id":"GO:0052106","count":2},{"id":"GO:0015747","count":2},{"id":"GO:0006004","count":2}]},{"hash":"2218103956392223421","title":"Nuclear transcription regulation and VEGF/Hippo signaling","description":"Based on the top GO terms, this cluster centers on DNA-templated transcription and regulation of nuclear export, with signaling pathways such as VEGF receptor signaling and Hippo, alongside immune and endothelial processes (virus response and T cell proliferation). This suggests a coherent theme of transcriptional control linked to vascular and immune signaling.","confidence":"Medium","size":7,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0046826","count":5},{"id":"GO:0098586","count":4},{"id":"GO:0043536","count":4},{"id":"GO:0033136","count":4}]},{"hash":"1517396997603856320","title":"Unknown","description":"The set of top GO terms spans very different processes, including brown fat and keratinocyte differentiation, various growth factor and signaling pathway regulations (FGFR/PDGFR, PI3K/AKT, VEGF), hormone/stimulus responses (FSH), immune-related response (muramyl dipeptide), nervous system development, pain perception, and apoptotic regulation. There isn\u2019t a single coherent biological theme tying these proteins together, so a single descriptive label cannot be confidently assigned.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0090336","count":4},{"id":"GO:0030216","count":4},{"id":"GO:0071372","count":4},{"id":"GO:0032495","count":4},{"id":"GO:0019233","count":4}]},{"hash":"596500398315950692","title":"Plant Hormone Biosynthesis and Fruit Ripening","description":"Most top GO terms point to biosynthesis and regulation of plant hormones (ethylene and gibberellin), along with processes tied to fruit ripening and related secondary metabolite pathways (proanthocyanidin). The cluster thus appears to represent hormone-driven maturation and associated metabolism, with some stress-related terms observed. A few terms (e.g., penicillin biosynthesis) may reflect annotation noise, but the dominant theme is plant hormone biosynthesis and ripening-related metabolism.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0009693","count":2},{"id":"GO:1902835","count":2},{"id":"GO:0042318","count":2},{"id":"GO:0010421","count":2}]},{"hash":"275739587940529763","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007219","count":4},{"id":"GO:0042853","count":4},{"id":"GO:0097053","count":4},{"id":"GO:0051384","count":4},{"id":"GO:0051591","count":4}]},{"hash":"702699906724576815","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042274","count":2},{"id":"GO:0046944","count":1},{"id":"GO:0000472","count":1},{"id":"GO:0000447","count":1},{"id":"GO:0000480","count":1}]},{"hash":"209364456065936263","title":"Neuroimmune signaling and behavior","description":"This cluster includes immune-related terms (negative regulation of TNF production, interleukin-12 production, response to xenobiotic stimulus, CD8+ T cell differentiation) alongside neural development and function terms (GABAergic interneuron migration, regulation of glutamatergic synaptic transmission) and behavior-related terms (eating behavior, temperature response). The combination suggests a theme where immune signaling interfaces with neural development and behavior regulation rather than a single narrow function.","confidence":"Medium","size":7,"edges":14,"triangles":13,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032720","count":7},{"id":"GO:0048609","count":7},{"id":"GO:0071502","count":7},{"id":"GO:0042755","count":7},{"id":"GO:0072610","count":7}]},{"hash":"1340855727225776258","title":"Ribosome Biogenesis and Translation Initiation","description":"The cluster is enriched for rRNA maturation (SSU/LSU, 5.8S), ribosome biogenesis, and translation initiation steps (preinitiation complex formation and reinitiation), with an additional note on rRNA methylation. This combination points to proteins involved in assembling functional ribosomes and kicking off translation.","confidence":"High","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000466","count":3},{"id":"GO:0036265","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3}]},{"hash":"871951999131435171","title":"Synaptic Vesicle Cycling and Excitatory Signaling","description":"The cluster shows a clear enrichment for synaptic-related GO terms, especially regulation of synaptic vesicle exocytosis and endocytosis, and excitatory postsynaptic potential, pointing to a role in synaptic transmission. While other terms (mitotic cell cycle, nucleolus localization, xenobiotic response) appear as well, the strongest signal centers on neuronal synaptic regulation, supporting this labeling.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0021762","count":2},{"id":"GO:2000300","count":2},{"id":"GO:1900242","count":2}]},{"hash":"285649730920639261","title":"Wnt inhibition and cell cycle/apoptosis control","description":"This cluster is enriched for negative regulation of canonical Wnt signaling, inhibition of cell proliferation, and promotion of apoptosis, suggesting a module that restrains growth and promotes cell fate decisions. The accompanying terms on nuclear transport, mitosis, and DNA replication regulation imply coordination with cell cycle and nuclear processes, reinforcing a theme of growth control linked to Wnt signaling and mitotic regulation.","confidence":"Medium","size":7,"edges":16,"triangles":17,"max_degree":6,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0090090","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0043065","count":5},{"id":"GO:0008285","count":5},{"id":"GO:0006607","count":4}]},{"hash":"1353506411257151118","title":"Unknown","description":"The GO terms for these proteins span RNA processing, translation, immune signaling (TNF and IL-12 production, CD8 T cell differentiation), stress responses (temperature and xenobiotic response), and developmental/behavioral processes (reproductive process, eating behavior), with no clear single biological theme tying them together. This diversity makes it inappropriate to assign a cohesive, specific label to the cluster.","confidence":"","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0033119","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0006407","count":1},{"id":"GO:0032720","count":1},{"id":"GO:0048609","count":1}]},{"hash":"1055295536701410866","title":"Unknown","description":"The top GO terms cover immune signaling (B cell receptor signaling, IgE isotype regulation, type 2 immune response) along with disparate development (nervous system, skeletal muscle, salivary gland branching), RNA modification (pseudouridine synthesis), and circadian/gravitropism processes, indicating no single cohesive function for the cluster.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0000455","count":1},{"id":"GO:0031119","count":1}]},{"hash":"1128747202138270406","title":"Dopaminergic signaling and sensory perception","description":"The cluster centers on neural and sensory processes: visual perception, pain perception, visual learning, and dopaminergic synaptic transmission, with associated signaling (GTPase regulation and protein phosphorylation) and behavior related to cocaine. Although a couple of terms touch on neuroendocrine and cardio development, the dominant theme is neuronal signaling and sensory processing.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007601","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0002035","count":4},{"id":"GO:0010759","count":4}]},{"hash":"842420477193934218","title":"Platelet Activation and Cardiovascular Signaling","description":"Most terms center on platelet function and signaling that governs cardiovascular regulation: platelet activation, GPCR signaling, adenylate cyclase pathways, and Rho-mediated signaling. A few terms are metabolic or inflammatory (electron transport chain, TNF regulation) and cell-wall\u2013related, which are less clearly connected to the core theme. Overall, the cluster seems to reflect a vascular/platelet signaling theme, with some outliers.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045777","count":3},{"id":"GO:0022900","count":3},{"id":"GO:0009253","count":3},{"id":"GO:0010579","count":3},{"id":"GO:0030168","count":3}]},{"hash":"1029187612632826703","title":"Cardiac action potential regulation","description":"Enriched terms center on cardiac electrical activity and membrane potential regulation (potassium ion transport across the plasma membrane; regulation of resting membrane potential; cardiac muscle cell action potential involved in contraction; atrial repolarization; regulation of heart rate by cardiac conduction). This points to a cohesive theme of cardiac electrophysiology. A few terms related to general cellular responses (nicotine, glucose stimulus, dsRNA) may reflect broader signaling contexts but do not override the central cardiac focus.","confidence":"High","size":7,"edges":14,"triangles":11,"max_degree":6,"top_function":"nervous system process","top_go_terms":[{"id":"GO:1990573","count":4},{"id":"GO:0060075","count":4},{"id":"GO:0086002","count":4},{"id":"GO:0098914","count":4},{"id":"GO:0086091","count":4}]},{"hash":"87757893709175282","title":"Embryonic organogenesis and tissue patterning","description":"This cluster\u2019s GO terms repeatedly point to the formation and patterning of diverse organs and tissues (fungiform papilla, cranial ganglion, renal vesicle, oviduct, larval cuticle patterns), alongside related cellular processes like calcium-dependent adhesion and chromatin remodeling that support developmental regulation. The common thread is organogenesis and tissue patterning across multiple lineages, not a single tissue or pathway, justifying a broad developmental label.","confidence":"Medium","size":7,"edges":15,"triangles":13,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0061198","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0022006","count":2},{"id":"GO:0035293","count":2},{"id":"GO:0086019","count":2}]},{"hash":"1856960029998667960","title":"Synaptic Exocytosis and GABAergic Transmission","description":"Dominant terms describe fast, calcium-dependent neurotransmitter release and regulation of GABAergic synapses, pointing to synaptic signaling and vesicle exocytosis. Supporting terms about intracellular transport and ER membrane organization fit vesicle trafficking in neurons. A few terms (ribophagy, ABA signaling) are less directly related and may reflect broader cellular processes or cross-species annotations, but the core signals favor a synaptic function theme.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":3},{"id":"GO:0099526","count":3},{"id":"GO:0030579","count":3},{"id":"GO:0032443","count":3},{"id":"GO:0032228","count":3}]},{"hash":"1222716346969570679","title":"Endocytosis and endosome trafficking","description":"The listed GO terms cluster around endocytosis, endosome localization, and transporter/receptor movement through Golgi and endosomal pathways, indicating a vesicle-trafficking/endocytic functional theme. Some terms touch on cytoskeletal dynamics, but the dominant signal is endocytic vesicle transport and localization.","confidence":"Medium","size":7,"edges":11,"triangles":7,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006897","count":7},{"id":"GO:1902307","count":7},{"id":"GO:0000042","count":7},{"id":"GO:0098887","count":7},{"id":"GO:0000266","count":7}]},{"hash":"975884675669037876","title":"Sulfation and Glycosaminoglycan Biosynthesis","description":"The cluster\u2019s GO terms cluster around adding sulfate groups and producing sulfated molecules: protein sulfation and peptidyl-tyrosine sulfation, sulfate assimilation, and glycosaminoglycan/proteoglycan biosynthesis (heparan sulfate; N-acetylglucosamine metabolism). Hormone and xenobiotic metabolism terms (estrogen catabolic and catecholamine metabolism) are often driven by sulfation for detoxification, reinforcing a unifying theme of sulfation-driven modification and sulfated macromolecule biosynthesis.","confidence":"High","size":7,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006805","count":3},{"id":"GO:0030206","count":3},{"id":"GO:0015015","count":3},{"id":"GO:0006477","count":3},{"id":"GO:0006584","count":3}]},{"hash":"223277016657006434","title":"Complement and Coagulation in Angiogenesis","description":"The top GO terms cluster around complement activation (lectin and alternative pathways) and downstream signaling, together with blood coagulation and cell adhesion/migration processes critical for sprouting angiogenesis. This combination points to immune-coagulation signaling guiding vascular remodeling and endothelial adhesion, with integrin regulation reinforcing cell-matrix interactions. A thyroid hormone generation term appears but is less central.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0001867","count":7},{"id":"GO:0090050","count":7},{"id":"GO:0007160","count":7},{"id":"GO:0006590","count":7},{"id":"GO:0007157","count":7}]},{"hash":"1348068064282901200","title":"Unknown","description":"The GO terms for this cluster are scattered across mitotic processes (spindle organization, G1/S transition), protein localization, stress response, and even nodulation, with several terms marked obsolete. There isn\u2019t a clear, single biological theme that unites the proteins, so a concise, representative label isn\u2019t well-supported.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0030472","count":1},{"id":"GO:0045175","count":1},{"id":"GO:0000082","count":1},{"id":"GO:0043618","count":1}]},{"hash":"369247868435471501","title":"B cell signaling and dendritic cell regulation","description":"This cluster is dominated by adaptive immune terms: B cell receptor signaling, regulation of IgE isotype switching, type 2 immune response, and positive regulation of dendritic cell differentiation, implying roles in antigen recognition and presentation. A few terms like circadian rhythm and gravitropism appear unrelated and may be incidental GO annotations. Overall, the core theme centers on adaptive immune signaling and dendritic cell regulation.","confidence":"High","size":7,"edges":7,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":5},{"id":"GO:0048294","count":5},{"id":"GO:0042748","count":5},{"id":"GO:0042092","count":5},{"id":"GO:0009958","count":5}]},{"hash":"693566990563420261","title":"Chromatin remodeling and transcription regulation","description":"The top GO terms cluster around chromatin localization to chromatin, histone modifications, nucleosome remodeling, and regulation of RNA polymerase II transcription/preinitiation complex assembly, indicating a shared role in chromatin dynamics that govern transcription. A few developmental terms appear but are secondary to the dominant chromatin/transcription signal. ","confidence":"High","size":7,"edges":7,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0043966","count":3},{"id":"GO:0001755","count":2},{"id":"GO:0003209","count":2}]},{"hash":"1804108551324065731","title":"Multisubstrate Membrane Transport","description":"These proteins cluster around diverse transmembrane transport processes, with GO terms pointing to plasma membrane transport of selenite, sialic acid, urate, potassium ions, and xenobiotics, as well as vesicular neurotransmitter loading. Some terms (fucose metabolism, replicative senescence, and a couple obsolete terms) are peripheral or unrelated, but the dominant theme is membrane transport. Confidence in this label is Medium.","confidence":"Medium","size":7,"edges":18,"triangles":22,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0097080","count":7},{"id":"GO:0015739","count":7},{"id":"GO:0052106","count":7},{"id":"GO:0015747","count":7},{"id":"GO:0006004","count":7}]},{"hash":"585909824380010439","title":"Neural development and cell adhesion","description":"The top GO terms are dominated by nervous system development, neuronal stem cell maintenance, and regulation of synapse assembly, with supporting roles for homophilic/heterophilic cell-cell adhesion. Although bone and heart development terms appear, the strongest signal centers on neural differentiation and synaptic connectivity, suggesting the proteins in this cluster are involved in neural development processes and cell adhesion guiding neural networks. Confidence: Medium","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0072137","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0003273","count":2}]},{"hash":"2132578620562742167","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090263","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0090394","count":2}]},{"hash":"453032787755025341","title":"Unknown","description":"The GO terms span apoptotic processes, various developmental pathways (face morphogenesis, axon guidance, nephrocyte diaphragm), light signaling and phototransduction (far-red and red light), circadian rhythm regulation, and transcriptional control, with no coherent single function linking the proteins. This broad and disjoint set suggests no clear shared theme for this cluster.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0060325","count":1},{"id":"GO:0042753","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0009585","count":1}]},{"hash":"966782647305160486","title":"Leukocyte adhesion and lectin signaling","description":"The proteins in this cluster show strongest enrichment for immune and trafficking-related GO terms: leukocyte tethering/rolling, positive regulation of adhesion molecule production, basophil activation, NK cell chemotaxis regulation, and signaling through C-type lectin receptors and the lectin pathway of complement. Lymph vessel morphogenesis also fits with immune cell movement in tissues. Cartilage condensation is less directly related, but overall the dominant theme is leukocyte recruitment and lectin-mediated signaling in inflammatory/tissue-remodeling contexts. ","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":3},{"id":"GO:0071226","count":3},{"id":"GO:2000502","count":2},{"id":"GO:0045575","count":2},{"id":"GO:0090403","count":2}]},{"hash":"1204785154949529350","title":"Macrophage Amino Acid Transport and NO Production","description":"This cluster centers on transport of amino acids and related compounds across the plasma membrane (e.g., D-alanine, D-serine, L-ornithine, ammonium) and includes macrophage activation and nitric oxide biosynthesis terms, suggesting a theme of membrane transport supporting macrophage immune functions and NO pathways. Some signaling regulation terms accompany this context, but the core pattern is membrane amino acid transport linked to macrophage activity.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010923","count":1},{"id":"GO:0006884","count":1},{"id":"GO:0006809","count":1},{"id":"GO:0070634","count":1},{"id":"GO:0042941","count":1}]},{"hash":"908000492465319537","title":"Skeletal and vascular development","description":"This cluster centers on bone formation and vascular patterning, with terms for limb development, ossification and osteoblast differentiation, coronary artery morphogenesis, and regulation of angiogenesis and endothelial cell migration, indicating coordinated skeletal and blood vessel development.","confidence":"High","size":7,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060173","count":4},{"id":"GO:0001937","count":4},{"id":"GO:0010811","count":4},{"id":"GO:0043931","count":4},{"id":"GO:0016525","count":4}]},{"hash":"969271583528297948","title":"Sphingolipid biosynthesis and lipid signaling","description":"The top GO terms cluster around sphingolipid metabolism\u2014sphingosine biosynthetic process, sphinganine metabolic process, and ceramide biosynthetic process\u2014indicating a focus on sphingolipid biosynthesis and turnover. A related term about glutamatergic synaptic transmission suggests a neuronal context where sphingolipids influence membrane properties and signaling. Taking these together, the cluster seems best described by sphingolipid biosynthesis and lipid signaling. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051968","count":2},{"id":"GO:0044130","count":1},{"id":"GO:0046512","count":1},{"id":"GO:0007053","count":1},{"id":"GO:0070542","count":1}]},{"hash":"501600753990027136","title":"Actin-driven synaptic remodeling and vesicle exocytosis","description":"The top GO terms converge on actin cytoskeleton dynamics (filopodium/lamellipodium assembly, actin reorganization), regulation of synapse structure/plasticity, and vesicle trafficking/exocytosis at synapses (including GABAergic transmission). Small GTPase signaling connects these processes, with some additional terms touching endothelial barrier mechanics through cytoskeletal roles. Overall, the cluster appears rooted in actin-driven remodeling linked to synaptic function and vesicle handling, though a few terms are more peripheral. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":3},{"id":"GO:0010592","count":3},{"id":"GO:0051835","count":3},{"id":"GO:2000300","count":3},{"id":"GO:0090307","count":3}]},{"hash":"165520095130941250","title":"Diverse small-molecule membrane transporters","description":"The top GO terms point to transmembrane transport across the plasma membrane for a variety of substrates (xenobiotics, vitamins, sugars, urate, ions) and include a vesicular transporter role, indicating a cluster of broadly acting membrane transport proteins rather than a single, specific pathway.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042891","count":7},{"id":"GO:0006855","count":7},{"id":"GO:0035461","count":7},{"id":"GO:0097080","count":6},{"id":"GO:0015739","count":6}]},{"hash":"1072383599856505348","title":"Retinoid and lipid hormone metabolism","description":"The set centers on retinol/retinal metabolism and lipid-derived signaling (prostaglandins and C21-steroid hormones), with additional related drug and carbohydrate metabolism terms. This pattern suggests a metabolic cluster focused on processing vitamin A and lipid hormones rather than a single enzymatic function.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":6},{"id":"GO:0042572","count":6},{"id":"GO:0071799","count":3},{"id":"GO:0006700","count":3},{"id":"GO:0001516","count":3}]},{"hash":"1082453905765605460","title":"Unknown","description":"The top GO terms span diverse processes\u2014including DNA replication, protein oligomerization, lipopolysaccharide biosynthesis, phospholipid remodeling, metal transport, and various biosynthetic/catabolic pathways\u2014which do not point to a single shared function; testosterone response and epoxygenase P450 pathway add to the heterogeneity, indicating no cohesive theme. This lack of a unifying function justifies labeling the cluster as Unknown.","confidence":"","size":6,"edges":6,"triangles":1,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0051260","count":2},{"id":"GO:0009103","count":2},{"id":"GO:0046839","count":2},{"id":"GO:0033574","count":2}]},{"hash":"1023489529713604968","title":"Calcium signaling in cardiac and diaphragmatic contraction","description":"The top GO terms point to calcium-dependent regulation of muscle activity, notably cardiac muscle contraction and diaphragm contraction, with related signaling (calcium/NFAT pathway) and mitochondrial calcium regulation. While a few terms (hypoxia response, ascospore formation, nuclear import) seem unrelated, the strongest recurring theme is calcium-dependent control of heart and respiratory muscle function, justifying a label focused on calcium signaling linked to cardiac/diaphragmatic contraction.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":3},{"id":"GO:0060048","count":3},{"id":"GO:0002086","count":3},{"id":"GO:0005513","count":2},{"id":"GO:0006607","count":2}]},{"hash":"1210841861108439681","title":"Cytoskeleton dynamics and cell adhesion","description":"The top GO terms point to microtubule regulation, spindle and contractile ring assembly, and zonula adherens maintenance, signaling a cohesive theme of cytoskeletal organization underpinning cell division, morphology, and cell\u2013cell junctions. A few terms touch on neurite maintenance and tissue morphogenesis, which fit under cytoskeletal scaffolding across contexts; plant chloroplast movement also relates to the same structural framework. Overall, the shared function appears to be cytoskeletal dynamics and junction maintenance rather than a single strict pathway.","confidence":"Medium","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1990942","count":3},{"id":"GO:1990535","count":3},{"id":"GO:0045218","count":3},{"id":"GO:0032886","count":3},{"id":"GO:0036334","count":3}]},{"hash":"1896887978623342042","title":"Neural development and axon guidance signaling","description":"This cluster is dominated by nervous system development terms (brain, axon guidance) and signaling pathways (Roundabout, Smoothened) that are closely tied to neural patterning and connectivity, suggesting a cohesive neural development focus. Some organ-development terms appear as broader developmental roles, but the neural theme remains prominent.","confidence":"Medium","size":6,"edges":10,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":5},{"id":"GO:0035385","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0001822","count":4},{"id":"GO:0050852","count":4}]},{"hash":"1558949106579019948","title":"Bacterial fatty acid metabolism and quinone biosynthesis","description":"The top GO terms cluster around lipid metabolism (fatty acid beta-oxidation, long-chain fatty acid biosynthesis, ketone body biosynthesis) and quinone biosynthesis (phylloquinone, menaquinone), with additional bacterial-associated catabolic and antibiotic biosynthetic processes; a stray liver development term may be incidental noise, but the overall theme is microbial energy metabolism and quinone production.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":3},{"id":"GO:0006635","count":3},{"id":"GO:0042594","count":2},{"id":"GO:0046951","count":2},{"id":"GO:0001889","count":2}]},{"hash":"1025381196401805706","title":"Vascular-immune signaling cluster","description":"The proteins appear involved in signaling networks that govern vascular biology and immune responses, as reflected by GO terms for VEGF receptor signaling, endothelial cell migration, Hippo and STAT signaling, and T cell activation, with additional but less central terms related to virus response and cell-cycle/kinase activity.","confidence":"Medium","size":6,"edges":12,"triangles":11,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0098586","count":6},{"id":"GO:0043536","count":6},{"id":"GO:0033136","count":6},{"id":"GO:0048010","count":6},{"id":"GO:0035329","count":6}]},{"hash":"1628377541077948040","title":"Cerebellar development and glial differentiation","description":"The cluster\u2019s top GO terms are strongly centered on cerebellar biology: Bergmann glial cell differentiation and cerebellar cortex formation, complemented by regulation of axon regeneration, which together indicate a neural development and glial differentiation theme specific to the cerebellum. While other terms (e.g., T cell receptor signaling, insulin signaling, cell cycle regulation) are more general and not as cerebellum-focused, they are less defining for the cluster. This combination supports naming the cluster around cerebellar development and glial differentiation, with some peripheral signaling contexts. ","confidence":"Medium","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045736","count":6},{"id":"GO:0034501","count":6},{"id":"GO:2001275","count":6},{"id":"GO:0060020","count":6},{"id":"GO:0050852","count":6}]},{"hash":"346310550016757930","title":"Lipid, Retinoid, and Steroid Metabolism","description":"The cluster is dominated by metabolic processes involving lipids and related compounds: retinal and retinol metabolism, 3-keto-sphinganine (a sphingolipid precursor) metabolism, and biosynthesis of steroid hormones (androgen and estrogen) as well as poly-hydroxybutyrate biosynthesis. These points suggest a cohesive theme around lipid and hormone metabolism, with a few outliers related to antibiotic and methotrexate responses that are less central.","confidence":"Medium","size":6,"edges":10,"triangles":5,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042574","count":3},{"id":"GO:0006666","count":3},{"id":"GO:0008209","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0017000","count":3}]},{"hash":"789212062391369707","title":"Fast-twitch muscle contraction and excitation-contraction coupling","description":"These GO terms cluster around skeletal muscle physiology, notably fast-twitch fiber contraction, T-tubule organization, membrane potential, and ion homeostasis, which together point to excitation-contraction coupling in fast muscle fibers. A few terms appear unrelated (lipopolysaccharide biosynthesis, propylene catabolic process), likely annotation noise, but the dominant muscle-focused theme supports this label.","confidence":"High","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":2},{"id":"GO:0042208","count":2},{"id":"GO:0010248","count":1},{"id":"GO:0014883","count":1},{"id":"GO:0035235","count":1}]},{"hash":"1424826401868732533","title":"Dopamine and Adrenergic GPCR Signaling","description":"This cluster is dominated by GO terms for dopamine receptor signaling and adrenergic receptor signaling, with downstream activation of adenylate cyclase and phospholipase C, plus related GTPase regulation and phosphatidylinositol biosynthesis. The presence of broader GPCR signaling terms (including acetylcholine receptor signaling) and heart development suggests a cohesive theme around GPCR-mediated signal transduction, particularly via dopamine/adrenergic pathways.","confidence":"High","size":6,"edges":12,"triangles":9,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007603","count":4},{"id":"GO:0060158","count":4},{"id":"GO:0007191","count":4},{"id":"GO:0071880","count":4}]},{"hash":"1584709146238954869","title":"Nuclear RNA Processing & Transcription Regulation","description":"The top terms cluster around nuclear processes: import into nucleus, spliceosomal snRNP assembly, transcription termination by RNA Pol II, snRNP maturation, and nuclear/transcript RNA turnover (deadenylation-decapping, histone mRNA metabolism, rRNA maturation). There are also some plant- or development-associated terms (abscisic acid response, hair cycle) that likely reflect broader regulatory contexts but do not override the core theme of nuclear RNA processing and transcription control.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051170","count":5},{"id":"GO:0000290","count":5},{"id":"GO:0008334","count":5},{"id":"GO:0009737","count":5},{"id":"GO:0030490","count":5}]},{"hash":"1741113712948021473","title":"Ribosome Biogenesis and Translation","description":"Dominant GO terms point to ribosome production and translation control, including translation (GO:0006412), ribosomal small subunit/SSU-rRNA maturation (GO:0000462, GO:0000028), and regulation of translational fidelity (GO:0006450). This creates a cohesive theme of ribosome biogenesis and accurate protein synthesis. A few outlier terms (axillary shoot meristem initiation, hemidesmosome assembly) likely reflect annotation noise rather than core function. Overall, the cluster seems to group proteins involved in ribosome biogenesis and translation regulation.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0000462","count":1},{"id":"GO:0090506","count":1},{"id":"GO:0034198","count":1},{"id":"GO:2000032","count":1}]},{"hash":"1624616578830344096","title":"Ubiquitin-Proteasome Degradation and Cell Cycle","description":"This cluster is dominated by ubiquitin-related catabolic processes (SCF-dependent degradation, K48-linked ubiquitination, autoubiquitination, ERAD, neddylation) and cell cycle regulation (APC/C-dependent catabolic process, cell division), suggesting a module centered on ubiquitin-mediated protein turnover and progression through the cell cycle; viral interactions may reflect ubiquitin-pathway hijacking.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0031146","count":5},{"id":"GO:0016032","count":5},{"id":"GO:0070911","count":5},{"id":"GO:0070936","count":4},{"id":"GO:0051301","count":4}]},{"hash":"1662099469043303616","title":"Regulation of translation initiation and IRES-dependent translation","description":"This cluster centers on control of translation initiation, including regulation of the initiation process, formation of the preinitiation complex, and translation reinitiation, with specific terms for IRES-dependent viral translation. A couple of terms touch on nuclear RNA processing and transcriptional regulation, but the dominant theme is translational control, including viral translation mechanisms.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006446","count":2},{"id":"GO:0071033","count":2},{"id":"GO:0075525","count":2},{"id":"GO:0034260","count":2},{"id":"GO:0002188","count":2}]},{"hash":"1550314919101696830","title":"Hypoxia-Responsive Signaling and Cell Cycle Regulation","description":"Based on the top GO terms, the cluster repeatedly features hypoxia response, kinase activity regulation (serine/threonine), and mitotic cell cycle processes, suggesting a theme of signaling pathways that coordinate cell proliferation under hypoxic stress. While there are a few outlier terms (e.g., bacterial septum digestion, mRNA transport), the dominant pattern points to hypoxia-driven phosphorylation signaling linked to cell cycle control.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071456","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0051028","count":3},{"id":"GO:0071902","count":3}]},{"hash":"1202533386662373167","title":"Immune activation and vesicle trafficking","description":"This cluster\u2019s terms cluster around immune signaling and cell communication (positive regulation of IL-2 production, immunological synapse formation, myeloid dendritic cell chemotaxis) and include endocytosis and intracellular trafficking (protein import into peroxisome matrix docking). While a few terms pertain to development or other processes, the strongest, recurrent theme is immune cell activation coupled with vesicle trafficking. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903764","count":1},{"id":"GO:1900042","count":1},{"id":"GO:0014070","count":1},{"id":"GO:1904694","count":1},{"id":"GO:0001771","count":1}]},{"hash":"2164082611815179203","title":"Developmental Signaling Regulators","description":"The cluster\u2019s top GO terms cluster around regulation of major signaling pathways (positive regulation of canonical Wnt signaling, Hippo signaling, and modulation of TGF-beta signaling) and processes linked to differentiation and growth (keratinocyte differentiation, cardiac muscle proliferation, apoptosis). Also includes nuclear export and protein degradation regulation, suggesting a group of proteins that modulate signaling networks and cell fate decisions rather than performing a single catalytic reaction. This supports a label of regulators of developmental signaling.","confidence":"Medium","size":6,"edges":13,"triangles":12,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0046827","count":4},{"id":"GO:0030512","count":3},{"id":"GO:0035329","count":2},{"id":"GO:0030216","count":2},{"id":"GO:0060044","count":2}]},{"hash":"589271225125504090","title":"Endocytic trafficking and signaling regulation","description":"This cluster centers on intracellular trafficking and signaling regulation, especially endocytosis and vesicle sorting (endocytosis; Golgi localization; endosome-to-postsynaptic transport; multivesicular body size), with accompanying signaling roles (Wnt pathway regulation) and neuronal survival signals (apoptosis regulation). A key theme is regulation of vesicle trafficking that interfaces with signaling pathways, though a few terms are broad or organism-specific, so the label is best as a general trafficking-and-signaling regulator.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":4},{"id":"GO:0043524","count":4},{"id":"GO:0043525","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0010796","count":4}]},{"hash":"2028301595207889325","title":"Developmental Signaling and Differentiation Regulators","description":"The cluster's top terms cluster around key developmental and growth-regulatory pathways (Hippo signaling, Wnt signaling, keratinocyte differentiation, myoblast fusion) and processes that control cell fate, proliferation, and survival (apoptotic regulation, transcription of ribosomal proteins). Although one plant-specific term (abscisic acid signaling) and a neuronal term (glutamatergic transmission) appear among the top terms, the dominant signal is developmental signaling and differentiation control, with several terms pointing to regulation of growth and tissue differentiation. This supports labeling the cluster as a set of proteins involved in developmental signaling and differentiation regulation.","confidence":"Medium","size":6,"edges":11,"triangles":10,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035329","count":4},{"id":"GO:0009738","count":4},{"id":"GO:0030216","count":4},{"id":"GO:0001324","count":4},{"id":"GO:0060963","count":4}]},{"hash":"1096678780348324653","title":"Ubiquitin-Proteasome Regulation","description":"The top GO terms cluster around ubiquitin-mediated protein turnover: deubiquitination, SCF-dependent ubiquitin ligase activity, and proteasome core complex assembly. This indicates a group centered on tagging/removing ubiquitin and assembling the proteasome for protein degradation, i.e., proteostasis control. Additional terms like salt/zinc response and mRNA stability are present but secondary to the main ubiquitin-proteasome theme.","confidence":"High","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":4},{"id":"GO:0051436","count":3},{"id":"GO:0009651","count":3},{"id":"GO:0031146","count":3},{"id":"GO:0002862","count":3}]},{"hash":"214825702030520818","title":"Vascular Development and ECM Remodeling","description":"This cluster centers on angiogenesis and vascular formation, with terms for endothelial and smooth muscle cell migration, and regulation of their behavior, coupled with extracellular matrix organization (cell-matrix adhesion, collagen fibril organization) and ERK signaling. The mix suggests a theme of blood vessel development and ECM remodeling, with occasional links to cartilage-related development and coagulation. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043536","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0048661","count":2},{"id":"GO:0007160","count":2},{"id":"GO:0001502","count":2}]},{"hash":"1335728097699765855","title":"Transmembrane Transporters","description":"The top GO terms are dominated by transport across membranes for various substrates (selenite, sialic acid, urate, xenobiotics, potassium ions) and even neurotransmitter loading into synaptic vesicles. This points to a cohesive function of membrane transporter activity handling small molecules and ions, including vesicle-related transport, across the plasma membrane. Therefore, a focused label of Transmembrane Transporters captures the common theme of the cluster.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097080","count":1},{"id":"GO:0015739","count":1},{"id":"GO:0052106","count":1},{"id":"GO:0015747","count":1},{"id":"GO:0006004","count":1}]},{"hash":"1817942798188766440","title":"Membrane Transporters (ions and metabolites)","description":"These GO terms are dominated by transmembrane transport activities across a range of substrates (ions like Na+, K+, phosphate; sugars such as galactose and fucose; vitamins and xenobiotics) and a specific case of neurotransmitter loading into synaptic vesicles. This consistency points to a common function as membrane transporter proteins, including vesicular transporters in neurons. ","confidence":"High","size":6,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":4},{"id":"GO:0006004","count":4},{"id":"GO:0042891","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0098700","count":4}]},{"hash":"204976551165442194","title":"Ubiquitination in immune signaling","description":"The top GO terms show a clear emphasis on ubiquitin and SUMO modifications (protein ubiquitination, sumoylation, and K48-linked ubiquitination) alongside immune-related processes (IL-17 signaling, V(D)J recombination, spleen development, T cell homeostasis, vitamin D response), suggesting these proteins function in immune cell development and signaling regulated by ubiquitin/SUMO pathways.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0016925","count":3},{"id":"GO:0090073","count":2},{"id":"GO:0070936","count":2},{"id":"GO:1903883","count":2}]},{"hash":"58996084356050420","title":"Unknown","description":"The top GO terms span disparate processes\u2014DNA repair, ionizing radiation response, PKC signaling, angiogenesis, growth hormone secretion, surfactant homeostasis, motor learning, organ identity maintenance, and general adaptation. There is no clear biological theme tying these proteins into a single coherent function or pathway, so a specific label cannot be justified.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006281","count":1},{"id":"GO:0010212","count":1},{"id":"GO:1904938","count":1},{"id":"GO:0070528","count":1},{"id":"GO:0001525","count":1}]},{"hash":"1415770671446148747","title":"Unknown","description":"The GO terms for this cluster are highly diverse (apoptosis-related terms, xenobiotic response, eye/platelet development, immune homeostasis, germ cell death, glucocorticoid response, and general protein processing), with no clear, shared biological function tying all six proteins together. Therefore a single, meaningful label cannot be confidently assigned.","confidence":"","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008635","count":1},{"id":"GO:0042493","count":1},{"id":"GO:0006309","count":1},{"id":"GO:0007605","count":1},{"id":"GO:0048749","count":1}]},{"hash":"1211140397113565539","title":"Embryonic Skeletogenesis and ECM Remodeling","description":"The terms point strongly to ossification processes (intramembranous and endochondral), skull morphogenesis, collagen catabolic activity, and extracellular matrix disassembly, plus skin development and overall multicellular development. Together, they indicate a cluster involved in embryonic skeletal formation with active ECM remodeling rather than a single isolated function. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001957","count":2},{"id":"GO:0001958","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0035987","count":2}]},{"hash":"556459364561847","title":"Autophagy and NK Cell Cytotoxicity","description":"This cluster centers on autophagy-related processes (autophagosome maturation, chaperone-mediated autophagy, lysosomal protein catabolic process, protein stabilization) together with NK cell cytotoxic functions (granzyme-mediated apoptotic signaling, regulation of NK cell degranulation) and an interferon response. The combination suggests a cohesive theme where autophagy-lysosome pathways intersect with immune effector activity in cytotoxic lymphocytes. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097352","count":1},{"id":"GO:0008626","count":1},{"id":"GO:0043323","count":1},{"id":"GO:1905146","count":1},{"id":"GO:1902513","count":1}]},{"hash":"2289938489440833321","title":"Neural progenitor mitosis and spindle organization","description":"This cluster is dominated by GO terms tied to mitotic spindle organization, spindle orientation, and contractile ring/actin assembly, including forebrain neuroblast division, indicating a core role in neural progenitor cell division and mitosis. Supporting terms on Golgi inheritance and organ identity reflect cell-cycle\u2013linked developmental processes, with some migration-related signals suggesting broader neurodevelopmental contexts.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021873","count":1},{"id":"GO:1902405","count":1},{"id":"GO:1903477","count":1},{"id":"GO:0048496","count":1},{"id":"GO:0007051","count":1}]},{"hash":"431623608148632550","title":"Lipid and Carbohydrate Biosynthesis with LPS Response","description":"The top GO terms cluster around fatty acid biosynthesis and multiple carbohydrate metabolism processes (fructose, sorbitol, xylulose-5-phosphate pathways) along with a response to lipopolysaccharide, suggesting a metabolic module centered on lipid and sugar biosynthesis that also engages stress signaling. This combination indicates a cohesive theme of metabolism linked to stress responses rather than a single, narrow pathway.","confidence":"Medium","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0006633","count":4},{"id":"GO:0032496","count":4},{"id":"GO:0043458","count":3},{"id":"GO:0046294","count":3},{"id":"GO:0006116","count":3}]},{"hash":"1823781795280863544","title":"Vascular development and metabolism","description":"The top GO terms point to blood vessel formation and heart-related development (venous morphogenesis, endocardial cushion migration, endothelial/smooth muscle involvement, angiogenesis regulation) with added signals of hypoxia response and glycolytic energy use, suggesting a cardiovascular morphogenesis cluster with metabolic adaptation. A few terms like sensory perception of sound or humoral immune response are less central to the core theme. ","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031639","count":1},{"id":"GO:0071456","count":1},{"id":"GO:0006096","count":1},{"id":"GO:0030855","count":1},{"id":"GO:0016525","count":1}]},{"hash":"464245768933355964","title":"Spliceosome-Mediated RNA Splicing Regulation","description":"This cluster centers on RNA splicing and its regulation via the spliceosome, as shown by the prominent GO terms for mRNA splicing (cis splicing via spliceosome) and positive regulation of splicing via spliceosome. The presence of regulatory ncRNA-mediated gene silencing aligns with RNA-based regulatory processes, with a secondary link to cell cycle suggesting spliceosomal control can influence progression. Overall, the proteins likely participate in spliceosome-driven RNA processing.","confidence":"High","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0048026","count":2},{"id":"GO:1901407","count":2},{"id":"GO:0006378","count":2}]},{"hash":"2242376271378912456","title":"Unknown","description":"The top GO terms are diverse (calcium ion detection, ascospore formation, calcineurin-NFAT signaling, cardiac hypertrophy, kinetochore localization, DNA damage checkpoint, EMT regulation, excitatory postsynaptic potential, meiotic cell cycle, and RNA Pol II transcription termination). This mix spans calcium signaling, fungal development, heart signaling, mitosis/meiosis, neural activity, and transcription, with no clear, single functional theme uniting all proteins. Confidence in a cohesive label is therefore None.","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0005513","count":5},{"id":"GO:0030437","count":5},{"id":"GO:0051531","count":5},{"id":"GO:0014898","count":5},{"id":"GO:0034501","count":5}]},{"hash":"197891934391997262","title":"Cytoskeletal dynamics and cell division","description":"The cluster's top GO terms cluster around cytoskeleton regulation\u2014mitotic spindle assembly, actomyosin contractile ring formation, and regulation of microtubule-based processes\u2014along with zonula adherens maintenance and nuclear migration, plus organelle and cell architecture aspects like chloroplast movement and neuron structure. These all point to a common theme of cytoskeletal organization driving division, adhesion, and cellular morphology across contexts.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1990942","count":4},{"id":"GO:1990535","count":4},{"id":"GO:0045218","count":4},{"id":"GO:0032886","count":4},{"id":"GO:0036334","count":4}]},{"hash":"1385813017225479236","title":"Developmental Transcriptional Regulation","description":"The terms cluster around transcription (DNA-templated transcription; RNA polymerase II transcription) and a variety of developmental pathways (hair follicle development; nephrogenesis morphogenesis; paramesonephric duct development; cerebellar signaling). The mix suggests proteins that coordinate development via transcriptional control rather than a single tissue-specific function.","confidence":"Medium","size":5,"edges":6,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0001942","count":2},{"id":"GO:0045805","count":2},{"id":"GO:2000346","count":2},{"id":"GO:0070527","count":2}]},{"hash":"917011599054536235","title":"Viral Infection and Host-Cell Interaction","description":"The cluster is dominated by GO terms tied to virus biology: virion assembly, entry of symbionts into the host, and proviral latency, along with leukocyte migration and lipid droplet organization, which are commonly involved in virus replication and host response. The mix of terms like protein peptidyl-prolyl isomerization and regulation of protein secretion also fits how viral proteins manipulate host pathways. Collectively these signals point to a coherent theme around viral infection, assembly, genome integration, and immune interaction.","confidence":"High","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019068","count":3},{"id":"GO:1901407","count":3},{"id":"GO:0030260","count":2},{"id":"GO:0050900","count":2},{"id":"GO:2000276","count":2}]},{"hash":"1769231448278180325","title":"ER-Golgi Trafficking and Mitosis","description":"The cluster shows strong signals for ER-Golgi and COPII vesicle transport (ER-to-Golgi and Golgi-to-ER) together with cell division and growth terms (mitotic cycle, spindle assembly, proliferation, multicellular growth), suggesting a module coupling intracellular trafficking with cell cycle progression during development.","confidence":"High","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008283","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0090114","count":3},{"id":"GO:0051301","count":3}]},{"hash":"122835524384241310","title":"Neural development and synapse assembly","description":"The top GO terms are centered on nervous system development, corpus callosum development, dendrite development, and synapse assembly, along with voltage-gated sodium channel clustering, indicating a coherent theme of neural development and synaptic organization (with a few outlier terms from other organ contexts).","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":5},{"id":"GO:0045162","count":5},{"id":"GO:0050773","count":5},{"id":"GO:1902960","count":5},{"id":"GO:0007399","count":5}]},{"hash":"195681093119289628","title":"Glycogen and Starch Metabolism","description":"The top GO terms show both anabolic and catabolic processes for glycogen, starch, and related polysaccharides (alpha-glucan, maltose, trehalose, sucrose), indicating a cohesive cluster centered on carbohydrate metabolism and storage polysaccharides rather than a single pathway.","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0005980","count":3},{"id":"GO:0005978","count":3},{"id":"GO:0019252","count":3},{"id":"GO:0044245","count":3},{"id":"GO:0000023","count":2}]},{"hash":"167987639413059556","title":"Unknown","description":"The GO terms are highly diverse, spanning cell division and DNA repair alongside various catabolic and metabolic processes (e.g., D-galactarate, sulfoquinovose catabolism, NADPH regeneration, L-valine biosynthesis), plus excretion and even circadian/ photosynthetic pathway terms. With no clear cohesive function linking the proteins and no interactions among them, there isn\u2019t a single interpretable theme to name the cluster convincingly.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0007588","count":1},{"id":"GO:0019510","count":1},{"id":"GO:0009854","count":1}]},{"hash":"1199953026167128545","title":"Unknown","description":"The terms span diverse biological areas (metabolism, development, transcription regulation, sporulation) with no shared pathway or function, and there are no protein\u2013protein connections; thus no cohesive theme to name\u2014Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0042208","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0042574","count":2},{"id":"GO:0008209","count":2}]},{"hash":"1390384245442535293","title":"Planar polarity and neural guidance signaling","description":"The GO terms point strongly to planar cell polarity (PCP) and neural guidance, with explicit mentions of planar polarity establishment, hair planar orientation, and axon guidance, plus related adhesion and signaling processes. While a few terms touch broader functions (inflammation, brown fat differentiation), the PCP and neural guidance theme dominates, supporting a cohesive label around PCP-driven development and tissue patterning.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007213","count":2},{"id":"GO:0036515","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0050873","count":2},{"id":"GO:0071504","count":2}]},{"hash":"1468956260250291382","title":"Ribosome biogenesis and RNA surveillance","description":"Top GO terms cluster around translation and rRNA maturation (translation, translational initiation, translational termination; maturation of SSU/5.8S/LSU rRNA), with RNA surveillance and decay pathways (no-go decay, non-stop decay, mRNA catabolic process) also represented. This points to a function in ribosome assembly and RNA quality control, with a minor outlier term related to larval hematopoiesis. ","confidence":"High","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006413","count":2},{"id":"GO:0000466","count":1},{"id":"GO:0070481","count":1},{"id":"GO:0071025","count":1}]},{"hash":"1816019646081194488","title":"Metabolic Stress and Immune Cytokine Regulation","description":"Top terms cluster around thermal/metabolic stress (temperature stimulus, diet-induced thermogenesis, xenobiotic response) and immune signaling (IL-12 production, TNF regulation). Although some terms are broad, the shared theme appears to be stress-responsive metabolic-immune regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0042391","count":4},{"id":"GO:0018298","count":4},{"id":"GO:0019233","count":4}]},{"hash":"1389967780823847189","title":"Neural signaling and sensory processing","description":"This cluster's top GO terms are heavily focused on neural signaling and sensory processing, including dopaminergic synaptic transmission, sensory perception of pain, visual perception and learning, and behavioral responses to cocaine, with ERK1/2 cascade regulation often involved in neuronal signaling. A few terms (thermogenesis and macrophage chemotaxis) are less central but may reflect broader regulatory roles.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":5},{"id":"GO:0071502","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0010759","count":3},{"id":"GO:0048148","count":3}]},{"hash":"467156362020439567","title":"Ribosome Biogenesis and rRNA Processing","description":"The dominant GO terms describe maturation and processing of rRNA (SSU/LSU), ribosome biogenesis, and nucleolus organization, indicating the proteins are primarily involved in ribosome assembly and ribosomal RNA maturation in the nucleolus. A couple of terms related to transcription regulation and DNA replication appear as secondary associations, but they do not contradict the central ribosome-focused theme. Overall, the cluster is best characterized by ribosome production and rRNA maturation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000466","count":1},{"id":"GO:0042273","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0044786","count":1},{"id":"GO:2000232","count":1}]},{"hash":"1448183510813261442","title":"Mitochondrial fission and ATP transport","description":"The top GO terms are dominated by mitochondrial processes\u2014mitochondrial membrane fission, mitochondrial ATP transmembrane transport, and related mitochondrial maintenance terms\u2014suggesting the proteins in this cluster mainly relate to mitochondrial dynamics and energy handling. While some terms are unrelated (platelet activation, liver regeneration), the strongest shared theme is mitochondrial fission and ATP transport.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030168","count":2},{"id":"GO:0030974","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0000002","count":2},{"id":"GO:0070542","count":2}]},{"hash":"525025521249702521","title":"Neural crest migration and nervous system development","description":"The terms cluster around neural crest\u2013derived lineages and neural differentiation: melanocyte migration and KIT signaling are central to melanocyte development from the neural crest, several GO terms describe neural crest cell migration in the sympathetic nervous system, and clustering of voltage-gated sodium channels points to neuronal maturation. Peripheral terms like vitamin D3 metabolism or endothelial chemotaxis exist but do not override the dominant neural crest/neural development theme.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0097324","count":1},{"id":"GO:0038109","count":1},{"id":"GO:0070640","count":1},{"id":"GO:2000546","count":1},{"id":"GO:0045162","count":1}]},{"hash":"44237059995903468","title":"Skin development and glucocorticoid signaling","description":"The top GO terms center on skin development and epidermal cell division, plus glucocorticoid signaling pathways, suggesting a group of proteins involved in epidermal biology and steroid hormone responses; trafficking terms like Golgi localization and protein targeting are compatible with secretory processes in skin cells. Overall, a cohesive theme around skin development modulated by glucocorticoids.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":1},{"id":"GO:0051683","count":1},{"id":"GO:0006713","count":1},{"id":"GO:0043588","count":1},{"id":"GO:1902309","count":1}]},{"hash":"489541395438402635","title":"Unknown","description":"Top terms span proteolysis, immune cell adhesion, seed development, and diverse metabolic pathways, with no single shared function tying the proteins together; the absence of edges/triangles and heterogeneous GO terms indicate no cohesive theme. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:0050901","count":2},{"id":"GO:0090410","count":1},{"id":"GO:0010214","count":1},{"id":"GO:0009234","count":1}]},{"hash":"1062706516523235043","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000447","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0007286","count":1},{"id":"GO:0018406","count":1}]},{"hash":"1143673670025670715","title":"Xenobiotic and vitamin membrane transporters","description":"The top GO terms are dominated by transmembrane transport, especially xenobiotic transmembrane transport, xenobiotic transport, and vitamin transmembrane transport, along with potassium ion transmembrane transport. This suggests a core function as membrane transporters handling xenobiotics and vitamins, with a possible secondary link to RNA processing terms that are less represented. Overall, the cluster most plausibly represents transporter proteins mediating small-molecule movement across membranes.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010610","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0042908","count":2}]},{"hash":"839826885817110183","title":"Diverse transmembrane solute transporters","description":"The top GO terms describe transmembrane transport of xenobiotics, vitamins, ions, nitrate, sialic acid, phosphate, and other substrates, indicating a cluster of membrane transporter proteins with broad substrate specificity.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":5},{"id":"GO:0035461","count":5},{"id":"GO:0042128","count":4},{"id":"GO:0015739","count":4},{"id":"GO:0035725","count":4}]},{"hash":"583675726604663041","title":"Unknown","description":"The GO terms associated with these four proteins are highly diverse and include obsolete toxin transport, virion and pore complex assembly, cytokine production, apoptosis regulation, telomere localization, and basic cell processes like cell division. This mix does not reveal a cohesive, single biological function or pathway that ties the proteins together, so a concise, representative label cannot be assigned beyond Unknown.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1901998","count":4},{"id":"GO:0071866","count":4},{"id":"GO:0051086","count":4},{"id":"GO:1904851","count":4},{"id":"GO:0051301","count":4}]},{"hash":"389834976611992713","title":"Cytoskeleton-driven cell division and adhesion","description":"The GO terms cluster around cytoskeletal dynamics (microtubule regulation, actomyosin ring assembly), cell junction maintenance (zonula adherens), and processes tied to nuclear movement and chromosomal events, indicating a theme of cytoskeletal remodeling during division and adhesion. Some terms touch neuronal or chloroplast movements, but the unifying mechanism appears to be cytoskeleton-mediated organization and movement in cells.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000742","count":4},{"id":"GO:1990942","count":2},{"id":"GO:1990535","count":2},{"id":"GO:0045218","count":2},{"id":"GO:0032886","count":2}]},{"hash":"1815863754307307201","title":"Unknown","description":"The terms include virion assembly, toxin transport, inflammatory cytokine production (IL-6 and TNF), apoptosis regulation, and other disparate processes like telomere localization and pore complex assembly. This mix suggests no single coherent function covers all four proteins, so a specific label is not reliable.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1901998","count":4},{"id":"GO:0071866","count":4},{"id":"GO:0051086","count":4},{"id":"GO:1904851","count":4},{"id":"GO:0051301","count":4}]},{"hash":"764892260956534697","title":"Membrane-trafficking and organelle-dynamics regulators","description":"Top terms point to regulation of mitochondrial fusion, tail-anchored ER protein insertion, and GPCR internalization, all related to membrane trafficking and organelle dynamics. While there are also transcriptional regulation terms, the strongest signal is regulation of organelle membranes and trafficking, suggesting a cluster of proteins involved in membrane-associated regulation and organelle behavior rather than a single cohesive pathway.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010637","count":4},{"id":"GO:1901340","count":4},{"id":"GO:0006357","count":4},{"id":"GO:0010216","count":4},{"id":"GO:0014070","count":4}]},{"hash":"1618088042113312993","title":"Post-transcriptional mRNA processing and export","description":"These proteins appear linked to post-transcriptional control: regulation of mRNA splicing (including alternative splicing via the spliceosome), mRNA export from the nucleus, mRNA stabilization, and regulation of translational initiation, with additional ncRNA-mediated gene silencing. Together, the terms suggest a common theme of RNA processing and export influencing gene expression, rather than transcriptional control.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048025","count":3},{"id":"GO:0031047","count":3},{"id":"GO:1902625","count":3},{"id":"GO:0048255","count":3},{"id":"GO:0006406","count":3}]},{"hash":"1466728568355936251","title":"Developmental apoptosis across tissues","description":"The GO terms cluster around programmed cell death in neural and germline tissues and broad developmental processes across organs (heart, lens, skeletal system, neuron projection). This points to apoptosis occurring within developing tissues as part of organogenesis, rather than a single signaling pathway, so the label reflects both developmental processes and apoptosis.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051402","count":3},{"id":"GO:0034349","count":3},{"id":"GO:0035234","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0051092","count":3}]},{"hash":"670429357385366433","title":"Neural development and synapse assembly","description":"The proteins are associated with nervous system development, corpus callosum development, dendrite development, and positive regulation of synapse assembly, as well as processes that organize neuronal signaling (e.g., sodium channel clustering), indicating a common theme of neuronal development and synaptic connectivity.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":4},{"id":"GO:0045162","count":4},{"id":"GO:0050773","count":4},{"id":"GO:1902960","count":4},{"id":"GO:0007399","count":4}]},{"hash":"2028464472204981145","title":"Unknown","description":"The top GO terms cover a wide range of distinct processes (metabolism, immune/immune-like response, cell adhesion and migration, development, neuronal signaling) with no clear shared function tying all four proteins. This makes it difficult to assign a specific, cohesive label to the cluster beyond Unknown.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0006633","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0007161","count":2},{"id":"GO:1990134","count":2}]},{"hash":"1586077592849956290","title":"ECM adhesion and integrin signaling","description":"This set of terms centers on extracellular matrix interactions and adhesion (integrin-mediated signaling, cell spreading, collagen remodeling), plus associated migration and tyrosine kinase signaling. The presence of heart development and osteoblast proliferation terms reflects tissue remodeling contexts where ECM dynamics and integrin signaling regulate morphogenesis and cell behavior, suggesting the cluster represents a module of ECM adhesion and integrin-driven signaling governing adhesion, spreading, and migration.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007508","count":2},{"id":"GO:0010710","count":2},{"id":"GO:2000406","count":2},{"id":"GO:0061097","count":2},{"id":"GO:0007229","count":2}]},{"hash":"2194806158290199045","title":"Unknown","description":"This cluster shows a mix of diverse processes (NF-kappaB regulation, sarcomere organization, morphogenesis, axon extension, symbiont entry, NK cell activation, xenobiotic response, melanocyte migration, Kit signaling) with no clear common function or interaction pattern, so there is no cohesive label that accurately represents a single theme.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0048803","count":2},{"id":"GO:0048675","count":2},{"id":"GO:0046718","count":2}]},{"hash":"776151462519503427","title":"Transcriptional regulation and myogenesis","description":"The prominent GO term is DNA-templated transcription, plus positive regulation of myoblast differentiation and Notch signaling regulation, all pointing to developmental gene expression control and muscle differentiation, with supporting signals in vasculogenesis. Several entries are obsolete, likely reflecting historical annotations, but the core theme is transcriptional regulation linked to differentiation. ","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0006351","count":1},{"id":"GO:0042265","count":1},{"id":"GO:0036138","count":1},{"id":"GO:0045746","count":1}]},{"hash":"1628823164377453515","title":"Seed Coat Phenylpropanoid and Lipid Metabolism","description":"The top GO terms cluster around seed-related biology (seed coat development and positive regulation of seed germination) together with lipid and phenylpropanoid metabolism (long-chain and very long-chain fatty acid metabolism, phenylpropanoid metabolic process, carnitine metabolic process). This combination suggests a plant-specific program coordinating seed coat formation with lipid-derived and phenylpropanoid biosynthesis, with some related energy- and metabolite-flow terms (malonate, acetyl-CoA related). Overall, the cluster likely represents proteins involved in seed coat construction and associated lipid/phenylpropanoid pathways.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090410","count":2},{"id":"GO:0010214","count":2},{"id":"GO:0009234","count":2},{"id":"GO:0009698","count":2},{"id":"GO:0043041","count":2}]},{"hash":"1030059141429105091","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042797","count":1},{"id":"GO:0006360","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0006366","count":1},{"id":"GO:0001172","count":1}]},{"hash":"1219406272741043117","title":"Glutamatergic signaling and ion transport","description":"The cluster is dominated by GO terms for potassium and sodium ion transmembrane transport, excitatory postsynaptic potential, membrane depolarization, and ionotropic glutamate receptor signaling, all central to glutamatergic neurotransmission and neuronal excitability. A few outlier terms appear but do not define the main function. This label reflects the core theme of ion-channel\u2013mediated signaling at glutamatergic synapses.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0051899","count":2},{"id":"GO:0035151","count":1}]},{"hash":"1963816767072411036","title":"Immune and endothelial signaling","description":"The terms cluster around innate and adaptive immune responses (response to dsRNA and virus, activated T cell proliferation, STAT phosphorylation) together with vascular/angiogenic signaling (VEGF receptor signaling, endothelial cell migration) and growth-related pathways (Hippo). This points to a shared theme of signaling networks coordinating immune activity with vascular development, hence an \"immune and endothelial signaling\" label. ","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071333","count":4},{"id":"GO:0043330","count":4},{"id":"GO:0098586","count":3},{"id":"GO:0043536","count":3},{"id":"GO:0033136","count":3}]},{"hash":"1539638119486268702","title":"Viral entry, genome integration, and latency","description":"The top GO terms cluster around viral infection processes: entry into the host cell and nucleus, reverse transcription (RNA-templated DNA synthesis), DNA integration and replication, and establishment of integrated proviral latency. Additional signals of host transcription regulation and RNA interference modulation, alongside symbiont-related effects on host apoptosis, support a theme of viral genome integration and control of host machinery. Overall, these proteins appear to participate in viral entry, genome integration, and latency maintenance.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":1},{"id":"GO:0006310","count":1},{"id":"GO:0039651","count":1},{"id":"GO:0046718","count":1},{"id":"GO:0015074","count":1}]},{"hash":"801404381943006537","title":"RNA Polymerase III Transcription","description":"The top GO terms are dominated by transcription by RNA polymerase III (including 5S rRNA transcription by Pol III and preinitiation complex assembly), suggesting the proteins assemble or function in the Pol III transcription machinery. A few terms related to angiogenesis and ossification appear, but they are likely incidental annotations; the core theme is Pol III transcription.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001009","count":1},{"id":"GO:0042791","count":1},{"id":"GO:0001041","count":1},{"id":"GO:0006359","count":1},{"id":"GO:0000999","count":1}]},{"hash":"1348657408036212479","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904876","count":1},{"id":"GO:0032211","count":1},{"id":"GO:0006370","count":1},{"id":"GO:0007175","count":1},{"id":"GO:1904751","count":1}]},{"hash":"889083948637775980","title":"Ubiquitin-Proteasome Proteolysis and Stress","description":"This cluster centers on ubiquitin-mediated proteolysis, highlighted by SCF-dependent ubiquitination and proteasomal degradation, with accompanying stress response and protein turnover signals. Circadian rhythm regulation and dormancy-related terms may reflect broader cell-cycle/host-interaction contexts, but the dominant theme is proteostasis under stress.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0085014","count":1},{"id":"GO:0006950","count":1},{"id":"GO:0051436","count":1},{"id":"GO:0031146","count":1},{"id":"GO:0006516","count":1}]},{"hash":"1029189099724330950","title":"Unknown","description":"Top terms span several unrelated processes (translation/ribosome maturation; actin cytoskeleton dynamics; development/morphogenesis; renal function; chromosome spindle localization), with no coherent single theme or protein\u2013protein interactions tying them together. This makes a specific, representative label unlikely, so the cluster is best described as Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0000470","count":1},{"id":"GO:0006417","count":1},{"id":"GO:0000147","count":1},{"id":"GO:0030041","count":1}]},{"hash":"623490203211069652","title":"Extrinsic apoptosis signaling and ubiquitin-dependent degradation","description":"Proteins in this cluster are annotated with extrinsic apoptotic signaling (death receptor\u2013mediated) and ubiquitin-dependent protein catabolic processes, including positively regulating cytochrome c release from mitochondria. This points to a theme of regulated proteolysis linked to apoptosis, making the label concise and representative despite limited network edges and some older/less relevant terms.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0010923","count":1},{"id":"GO:0008625","count":1},{"id":"GO:0001844","count":1},{"id":"GO:0090200","count":1}]},{"hash":"577767028249574223","title":"Unknown","description":"The top GO terms are highly diverse (thermogenesis and temperature response, pain perception, blood pressure regulation, mitochondrial electron transport, GPCR signaling, inflammation, calcium transport, and even developmental terms), with no clear single function tying all four proteins together. This makes it hard to assign a cohesive, specific label. None","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":2},{"id":"GO:0002024","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0045777","count":2},{"id":"GO:0022900","count":2}]},{"hash":"1253651186937771376","title":"Immune signaling and differentiation","description":"The top GO terms include B cell receptor signaling and IgE regulation, indicating immune signaling, while several terms focus on differentiation of various cell types (stem cells, skeletal muscle), suggesting a broader link to developmental processes. The cluster appears to combine immune signaling with differentiation/dvelopmental roles, but the terms are diverse and not tightly cohesive, so the connection is moderate.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":2},{"id":"GO:0035914","count":2},{"id":"GO:0071226","count":2},{"id":"GO:0032436","count":2},{"id":"GO:0048863","count":2}]},{"hash":"1675732069914319038","title":"Glycan fucosylation and cell migration","description":"The top terms cluster around glycosylation and fucosylation processes (N-glycan fucosylation, Lewis A biosynthesis, L-fucose metabolism) alongside cell migration and differentiation in immune and neural contexts (leukocyte migration, regulatory T cell differentiation, cerebral cortex and neuronal stem cell migration). This suggests a shared theme where fucosylated glycans influence cell movement and immune/neural development, making a glycosylation-migration linkage a concise, representative label. ","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0002522","count":1},{"id":"GO:0036071","count":1},{"id":"GO:0021799","count":1},{"id":"GO:0006486","count":1},{"id":"GO:0042355","count":1}]},{"hash":"1092518022661192233","title":"Pollen exine formation and plant cell wall biosynthesis","description":"This cluster centers on pollen exine formation and plant cell wall polysaccharide biosynthesis, including glucuronoxylan and related cell-wall processes, plus plant-type secondary cell wall biogenesis, indicating proteins involved in pollen wall construction and general cell wall assembly. The proteoglycan biosynthetic terms likely reflect annotation breadth, but the dominant theme is plant cell wall formation.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010584","count":2},{"id":"GO:0015012","count":2},{"id":"GO:0071555","count":1},{"id":"GO:0010417","count":1},{"id":"GO:0050650","count":1}]},{"hash":"1616704131914609183","title":"Secretory vesicle trafficking and fusion","description":"This cluster centers on vesicle fusion and secretion across secretory pathways (Golgi/ERGIC, SNARE complex assembly, vacuole fusion, autophagosome docking) and outputs like mucus and histamine secretion; insulin signaling and related processes appear as ancillary regulatory aspects, but the shared theme is vesicle trafficking to membranes and secretion.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":1},{"id":"GO:0048280","count":1},{"id":"GO:0035493","count":1},{"id":"GO:0034197","count":1},{"id":"GO:0043134","count":1}]},{"hash":"1431862350011206118","title":"Glycosaminoglycan proteoglycan biosynthesis and sulfation","description":"The terms cluster around synthesis and modification of proteoglycans (heparan sulfate, heparin, chondroitin sulfate) and related sulfation pathways, supported by building-block metabolism like N-acetylglucosamine and sulfate assimilation, pointing to a proteoglycan GAG biosynthesis and sulfation theme.","confidence":"High","size":4,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006805","count":3},{"id":"GO:0030206","count":3},{"id":"GO:0015015","count":3},{"id":"GO:0006477","count":3},{"id":"GO:0006584","count":3}]},{"hash":"1833564530274759827","title":"Unknown","description":"The terms mix bacterial redox-related biosynthesis (mycothiol), angiogenesis, polyamine metabolism (spermine), and chromatin/epigenetic processes (centromeric cohesion, histone acetylation, heterochromatin formation) with no clear, shared function linking all proteins. This heterogeneity makes it inappropriate to assign a confident, representative label.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010125","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0046208","count":2},{"id":"GO:0071962","count":2},{"id":"GO:0017198","count":2}]},{"hash":"63144274286998999","title":"Cardiac and neural development","description":"The top GO terms point to heart development processes (cardiac vascular smooth muscle cell development, cardiac septum morphogenesis, endocardial cushion to mesenchymal transition in heart valve formation) with additional neural development themes (neural retina development, neuroblast fate determination, noradrenergic neuron fate commitment, vestibular nucleus development). Together, these suggest a cluster centered on embryonic organogenesis affecting both cardiac and nervous system lineages, rather than a single narrowly defined pathway.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060948","count":3},{"id":"GO:0060411","count":3},{"id":"GO:2000981","count":3},{"id":"GO:0003199","count":3},{"id":"GO:0003359","count":3}]},{"hash":"1880508978356246061","title":"Stem cell and vascular regulation","description":"The top GO terms show promotion of stem cell proliferation, blood vessel branching, and smooth muscle differentiation, suggesting roles in stem cell growth and vascular development. Other terms (transcription, DNA repair, inflammation-related processes) are more diverse and do not form a single coherent theme, so the stem-cell\u2013vascular regulation label best captures the dominant signals.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2000648","count":3},{"id":"GO:0036047","count":2},{"id":"GO:1905555","count":2},{"id":"GO:0006471","count":2},{"id":"GO:1900226","count":2}]},{"hash":"1122542720033327608","title":"Neural development and synapse organization","description":"These proteins are linked by GO terms centered on nervous system development and synaptic organization, including corpus callosum development, dendrite development, synapse assembly, and clustering of voltage-gated sodium channels. The strongest signals point to roles in neural circuit formation and synaptic organization, making this an intuitive label for the cluster.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":3},{"id":"GO:0045162","count":3},{"id":"GO:0050773","count":3},{"id":"GO:1902960","count":3},{"id":"GO:0007399","count":3}]},{"hash":"1550885246606454912","title":"Plant xenobiotic and metal ion stress response","description":"This cluster shows GO terms related to detoxification and responses to xenobiotics and metals (xenobiotic/toxin catabolic processes, herbicide response, zinc and aluminum ion responses) and includes a plant hormone signaling term (auxin-activated signaling) and senescence regulation, suggesting a broader stress/detox theme in plants, albeit with some unrelated terms that add noise.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042178","count":1},{"id":"GO:0009635","count":1},{"id":"GO:0002182","count":1},{"id":"GO:0042594","count":1},{"id":"GO:0010043","count":1}]},{"hash":"418688912051174549","title":"Neuronal vesicle trafficking","description":"The top GO terms cluster around endosome localization, endocytosis, and regulation of synaptic vesicle exocytosis, as well as neurotransmitter receptor transport from endosomes to the postsynaptic membrane and brain development, pointing to a function in neuronal vesicle trafficking and endosomal dynamics. Some terms about Golgi localization or mitochondrial fission are ancillary, but the core theme is neuronal vesicle trafficking.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036010","count":2},{"id":"GO:2000300","count":2},{"id":"GO:0010796","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0031384","count":2}]},{"hash":"1838872326413601606","title":"Translation initiation complex assembly","description":"The top GO terms cluster around translation initiation\u2014translation reinitiation, formation of the translation preinitiation complex, and protein heterotrimerization\u2014suggesting these proteins participate in assembling the translation initiation machinery.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":2},{"id":"GO:0070208","count":2},{"id":"GO:0001731","count":2},{"id":"GO:2001162","count":1},{"id":"GO:0000920","count":1}]},{"hash":"1117345768242618594","title":"Neural development and synapse assembly","description":"The top terms cluster around nervous system development, corpus callosum development, dendrite regulation, and positive regulation of synapse assembly, plus processes involving clustering of voltage-gated sodium channels. This points to neuronal differentiation and synaptic organization as the core theme, despite a couple non-neural terms in the set.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":3},{"id":"GO:0045162","count":3},{"id":"GO:0050773","count":3},{"id":"GO:1902960","count":3},{"id":"GO:0007399","count":3}]},{"hash":"1852441552458477095","title":"Neural development and synapse assembly","description":"The proteins in this cluster are enriched for nervous system development, corpus callosum development, dendrite development, and positive regulation of synapse assembly, with related neuronal signaling features such as clustering of voltage-gated sodium channels, indicating a coherent theme of neural development and synaptic organization.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":3},{"id":"GO:0045162","count":3},{"id":"GO:0050773","count":3},{"id":"GO:1902960","count":3},{"id":"GO:0007399","count":3}]},{"hash":"1331066224594402230","title":"Unknown","description":"The top GO terms cover a mix of immune/coagulation, tissue remodeling, development (skin, kidney, enamel), and extracellular matrix-related processes, with no single unifying function across the cluster and no edges linking proteins. This makes it difficult to assign a specific, cohesive label, so Unknown with None confidence is appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0043277","count":2},{"id":"GO:0097186","count":2},{"id":"GO:0071397","count":2},{"id":"GO:1903238","count":2}]},{"hash":"205407490957923470","title":"Proteostasis: Protein quality control and trafficking","description":"The terms point to proteostasis activities: nuclear export regulation, ubiquitin-proteasome quality control, misfolded protein transport, and targeting of proteins to membranes; together they reflect management and clearance of misfolded or aberrant proteins. Some listed terms, such as mesoderm formation or hormone response, seem peripheral and not essential to the core theme.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0090084","count":1},{"id":"GO:0071374","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0006469","count":1},{"id":"GO:0046825","count":1}]},{"hash":"2120069376921104762","title":"Endosomal Vesicle Formation and Microautophagy","description":"The GO terms show a clear signal for endosome-associated vesicle biogenesis, including intralumenal vesicle formation and late endosomal microautophagy, which anchors the cluster\u2019s function. While other terms touch on related stress responses and organelle protein handling, the strongest link among the terms is endosomal vesicle formation and autophagic turnover.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070676","count":1},{"id":"GO:0034599","count":1},{"id":"GO:0034214","count":1},{"id":"GO:0035494","count":1},{"id":"GO:0043335","count":1}]},{"hash":"1616872811309181926","title":"Neural development and synapse assembly","description":"The dominant GO terms point to nervous system development, corpus callosum development, dendrite development, and synapse assembly, with clustering of voltage-gated sodium channels\u2014together indicating roles in neuronal differentiation, connectivity, and synaptic organization. Some non-neural terms appear, but the strongest signal is neural development.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":3},{"id":"GO:0045162","count":3},{"id":"GO:0050773","count":3},{"id":"GO:1902960","count":3},{"id":"GO:0007399","count":3}]},{"hash":"1711938385812878194","title":"Inflammation Regulation and Oxidative Detoxification","description":"The top GO terms cluster around dampening inflammatory signaling (NF-kappaB, TNF production, neutrophil aggregation) and detoxifying oxidants, with related terms in prostaglandin biosynthesis and nitric oxide storage. This suggests a module focused on anti-inflammatory regulation and oxidative stress management, with a few peripheral terms related to insulin signaling and regeneration.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2000255","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0032720","count":2},{"id":"GO:0002674","count":2},{"id":"GO:0032869","count":2}]},{"hash":"1413065696006391272","title":"SRP-Dependent Targeting and Sec Secretion","description":"Proteins in this cluster are characterized by GO terms for SRP-dependent cotranslational targeting to the membrane, Sec-mediated transport, and protein secretion, indicating a common function in directing proteins to membranes and their secretion via SRP and Sec pathways.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006616","count":1},{"id":"GO:0006605","count":1},{"id":"GO:0031204","count":1},{"id":"GO:0043952","count":1},{"id":"GO:0009306","count":1}]},{"hash":"1459386638251041348","title":"Vertebrate Embryogenesis Across Tissues","description":"The GO terms point to diverse embryonic development roles across multiple tissues (hindbrain patterning, organogenesis in retina, pituitary, digits, and spinal neurons), suggesting a broad vertebrate embryogenesis theme rather than a single molecular function.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021570","count":2},{"id":"GO:0038092","count":2},{"id":"GO:0048536","count":2},{"id":"GO:0061205","count":2},{"id":"GO:0060041","count":2}]},{"hash":"492983327099084636","title":"Glycinergic neurotransmission and transport","description":"Based on the top GO terms, the cluster centers on neurotransmitter handling in the nervous system, especially glycine-related processes: glycine secretion/import and regulation of glycinergic synaptic transmission, along with broader neurotransmitter transport/secretory activities (dopamine uptake, serotonin secretion). A few terms reference neural development, but the strongest common theme is glycine-mediated synaptic signaling and related transport.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015820","count":1},{"id":"GO:0051583","count":1},{"id":"GO:0021984","count":1},{"id":"GO:1905847","count":1},{"id":"GO:0042066","count":1}]},{"hash":"1097417504158760416","title":"Chromatin remodeling and DNA repair","description":"This cluster is defined by GO terms centered on chromatin dynamics and genome maintenance, including replication-born double-strand break repair via sister chromatid exchange, regulation of nucleosome density, histone modification (H3-K36 trimethylation), and DNA methylation, pointing to epigenetic regulation and DNA repair processes. Some terms are flagged as obsolete, but the dominant theme ties to chromatin state and genome integrity.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1990414","count":2},{"id":"GO:0060303","count":2},{"id":"GO:0001542","count":2},{"id":"GO:0042593","count":2},{"id":"GO:0014070","count":1}]},{"hash":"1534772952307661107","title":"Neuronal development and neurotransmission","description":"The top GO terms point to neuron formation and differentiation (dendrite morphogenesis, hippocampus development, neuron fate determination) alongside synaptic function (evoked neurotransmitter secretion, SNARE complex disassembly, endocytosis). This combination indicates a cluster of proteins involved in neuronal development and synaptic vesicle cycling, with supporting links to mitochondrion regulation as a downstream cellular context. Therefore, the name captures the core theme of neuronal development and synaptic activity.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048813","count":2},{"id":"GO:0021766","count":2},{"id":"GO:1902583","count":1},{"id":"GO:0035494","count":1},{"id":"GO:0061670","count":1}]},{"hash":"332272631475772087","title":"Retroviral life cycle components","description":"The top GO terms cluster around key viral lifecycle steps: entry into host, virion assembly, and RNA-templated DNA biosynthesis (reverse transcription) with mention of proviral latency, suggesting retroviral replication and integration. Additional terms on lipid droplets and secretion machinery reflect cellular processes viruses hijack during replication, supporting a virus-host interaction theme. Overall, the cluster seems to reflect retroviral lifecycle functions rather than a single host pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030260","count":2},{"id":"GO:0050900","count":2},{"id":"GO:2000276","count":2},{"id":"GO:0019068","count":2},{"id":"GO:0000413","count":2}]},{"hash":"44210068083122437","title":"Ribosome Biogenesis and Translation","description":"The top GO terms cluster around ribosome production and function: ribosome biogenesis, small subunit biogenesis/assembly, maturation of SSU-rRNA, ribosomal assembly, and translation. While a few terms like brain development or starvation response are present, the dominant theme is ribosome assembly and protein synthesis, making this a concise label for the cluster.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042274","count":1},{"id":"GO:0030490","count":1},{"id":"GO:1900153","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0006412","count":1}]},{"hash":"295278152231146681","title":"Neuronal and cardiac membrane excitability and ion transport","description":"This cluster's top GO terms cluster around membrane excitability: neuronal action potentials, atrial membrane repolarization, regulation of cardiac membrane potential, and potassium ion export. Together these point to a shared function in controlling membrane potential and signal transmission in neural and cardiac tissues, with additional terms related to synaptic regulation. A few terms (phytochelatin biosynthesis, obsolete Wnt signaling) appear peripheral or noisy, but do not override the dominant excitability theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046938","count":1},{"id":"GO:0006508","count":1},{"id":"GO:1904715","count":1},{"id":"GO:0043085","count":1},{"id":"GO:0044335","count":1}]},{"hash":"744734742803559996","title":"Axon Guidance and Growth Cone Dynamics","description":"The prominent GO terms point to axon guidance and filopodium assembly, hallmark activities of growth cone navigation and neurite extension. The presence of endocytosis and neurotransmitter receptor transport terms suggests neuronal trafficking to synapses. Taken together, the cluster likely represents neuronal development and growth cone dynamics with associated vesicle and cytoskeletal processes.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":3},{"id":"GO:0007411","count":3},{"id":"GO:0051496","count":3},{"id":"GO:0006897","count":2},{"id":"GO:1902307","count":2}]},{"hash":"1659313941900311343","title":"Cardiac development and coagulation pathways","description":"This cluster\u2019s GO terms cluster around heart and vessel formation (coronary artery morphogenesis, cardiac septum morphogenesis, vascular smooth muscle development) and coagulation-related processes (blood coagulation, plasminogen activation, TGF-beta production). Supporting terms related to hypoxia response and acetylcholine signaling reflect cardiovascular signaling contexts, suggesting a cohesive cardiogenesis\u2013coagulation module. ","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009750","count":1},{"id":"GO:0061476","count":1},{"id":"GO:0031639","count":1},{"id":"GO:0060982","count":1},{"id":"GO:0060948","count":1}]},{"hash":"758900164955317957","title":"DNA Repair: BER and NER","description":"The GO terms show strong representation of base-excision repair (BER) and nucleotide-excision repair (NER), including depurination/depyrimidination repair, indicating the proteins cluster around DNA damage repair functions. A xenobiotic stimulus response is also present, which often accompanies DNA damage responses to external chemicals. Overall, the cluster appears to be a set of proteins involved in repairing chemically damaged DNA.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":1},{"id":"GO:0033158","count":1},{"id":"GO:1902800","count":1},{"id":"GO:0045008","count":1},{"id":"GO:0032355","count":1}]},{"hash":"22937619880595259","title":"Ribosome Biogenesis and Translation","description":"The most frequent GO terms point to ribosome assembly, ribosomal subunit export, cytoplasmic translation, and tRNA modification, all central to protein synthesis. Additional terms about cell division and cell cycle align with growth-associated processes often coordinated with ribosome biogenesis. Together, this suggests a cluster of proteins involved in ribosome production and translation, with a link to cell division.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:1903833","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0015684","count":2},{"id":"GO:0000055","count":2}]},{"hash":"1029251573822102905","title":"Neuronal ubiquitin-proteasome regulation and synapse development","description":"Enrichment for ubiquitin-proteasome related terms (positive regulation of ubiquitin-protein transferase activity; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process) alongside neuron-specific terms (positive regulation of neuron projection development; positive regulation of synapse assembly) suggests the cluster centers on ubiquitin-mediated control of neuronal connectivity and synapse formation. The apoptotic process term may reflect downstream effects but the dominant signal is ubiquitin-regulated neuronal development.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0051443","count":3},{"id":"GO:0031146","count":3},{"id":"GO:0010976","count":3},{"id":"GO:0035458","count":3},{"id":"GO:0009737","count":3}]},{"hash":"910332484470980489","title":"Innate Immune Signaling and Leukocyte Adhesion","description":"The top GO terms are dominated by innate immune processes: complement activation via the lectin pathway, C-type lectin receptor signaling, leukocyte tethering/rolling, and basophil activation. There is also a note of NK cell chemotaxis regulation, indicating immune modulation. While a few terms touch development (cartilage condensation, lymph vessel morphogenesis), the prevailing signal points to immune recognition and leukocyte activation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":1},{"id":"GO:2000502","count":1},{"id":"GO:0071226","count":1},{"id":"GO:0045575","count":1},{"id":"GO:0090403","count":1}]},{"hash":"911732182138238286","title":"Cardiovascular development and coagulation","description":"This cluster's GO terms cluster around heart formation and vascular development (coronary artery morphogenesis, cardiac vascular smooth muscle development, cardiac septum morphogenesis), associations with coagulation and plasminogen activation, and related signaling affecting heart tissue (GPCR acetylcholine signaling, hypoxia response), pointing to a shared theme of cardiovascular development and hemostasis.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009750","count":1},{"id":"GO:0061476","count":1},{"id":"GO:0031639","count":1},{"id":"GO:0060982","count":1},{"id":"GO:0060948","count":1}]},{"hash":"623828099692673631","title":"Unknown","description":"The GO terms span markedly different biology (nitrate assimilation, myelin maintenance, sebaceous gland differentiation, nitric oxide biosynthesis/signaling, fatty acid and ergosterol biosynthesis, glycosphingolipid metabolism, and mitochondrial inheritance), with no coherent single function uniting the cluster. ","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":3},{"id":"GO:0032286","count":3},{"id":"GO:0001949","count":3},{"id":"GO:0006809","count":3},{"id":"GO:0006636","count":3}]},{"hash":"605258390874117132","title":"Unknown","description":"The GO terms include growth hormone secretion regulation and a mix of aromatic compound catabolism, photosynthesis-related processes, transport, and other metabolism terms, which do not converge on a single clear function for the cluster.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060124","count":2},{"id":"GO:0042203","count":1},{"id":"GO:0042128","count":1},{"id":"GO:0046381","count":1},{"id":"GO:0055114","count":1}]},{"hash":"80808647276676496","title":"Unknown","description":"The GO terms are highly diverse, spanning xenobiotic response, neuronal development, erythrocyte differentiation, pituitary development, neurotransmitter metabolism, epigenetic regulation, and apoptosis. There is no single cohesive function or pathway uniting these terms, suggesting multifunctionality or ambiguous annotation. Therefore, I cannot assign a specific thematic label.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":3},{"id":"GO:0010976","count":3},{"id":"GO:0010725","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0042420","count":3}]},{"hash":"2226121589511021449","title":"Cellular stress signaling regulators","description":"This cluster\u2019s top GO terms center on regulation of various signaling pathways ( VEGF, IL-6, HGF ), the unfolded protein response via IRE1, and ER-stress\u2013induced apoptotic signaling, with additional terms related to adhesion and cell-cycle regulation. The common link appears to be proteins that modulate cellular signaling in response to stress, rather than a single pathway. Thus, a label like Cellular stress signaling regulators captures the overarching theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030948","count":2},{"id":"GO:0046959","count":1},{"id":"GO:0070104","count":1},{"id":"GO:0035644","count":1},{"id":"GO:1902202","count":1}]},{"hash":"316376840000385075","title":"DNA repair and genome maintenance","description":"The terms are dominated by multiple DNA repair pathways (base excision repair, nucleotide excision repair, and repair of DNA alkylation) plus DNA recombination and regulation of repair processes, indicating a core function in genome maintenance; xenobiotic and estradiol response terms may reflect broader stress signaling but do not override the repair-focused theme.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":1},{"id":"GO:0033158","count":1},{"id":"GO:1902800","count":1},{"id":"GO:0045008","count":1},{"id":"GO:0032355","count":1}]}]