{"hash":"268315991571425121","title":"Negative regulation of adaptive type 2 immune responses","description":"The top GO terms cluster around dampening adaptive immune functions and Th2-type activity, including negative regulation of T cell proliferation, suppression of IL-4 and isotype switching (IgE/IgG), and general negative regulation of inflammatory and type 2 immune responses, with a minor signal about protein ubiquitination. This suggests the proteins act to downregulate humoral and cellular immune activation, particularly type 2 responses.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"members":[{"accession":"XP_041054590.1","go_terms":["GO:0042130","GO:0048302","GO:0032410","GO:0002829","GO:0030001","GO:0051224","GO:0002761","GO:0050728","GO:0007034","GO:0048294","GO:0032713","GO:0045619","GO:0031398","GO:0043123"]},{"accession":"XP_041070665.1","go_terms":["GO:0000301","GO:0007030"]},{"accession":"XP_041031998.1","go_terms":["GO:0006694"]}],"graph":[["XP_041031998.1","XP_041070665.1",0.781],["XP_041054590.1","XP_041070665.1",0.759]],"all_go_terms":{"GO:0048294":1,"GO:0042130":1,"GO:0032713":1,"GO:0045619":1,"GO:0030001":1,"GO:0002761":1,"GO:0050728":1,"GO:0002829":1,"GO:0031398":1,"GO:0048302":1,"GO:0007034":1,"GO:0051224":1,"GO:0043123":1,"GO:0032410":1,"GO:0000301":1,"GO:0007030":1,"GO:0006694":1},"recipe_readded":[]}