{"hash":"2234618001898001812","title":"Mitochondrial respiration and Fe-S cluster assembly","description":"This cluster is dominated by mitochondrial functions: mitochondrial translation, electron transport components such as succinate dehydrogenase, and regulation of iron-sulfur (Fe-S) cluster biology (Fe-S cluster assembly and iron incorporation into metallo-sulfur clusters), as well as regulation of ferrochelatase activity and cytochrome c release, plus a response to hydrogen peroxide. The convergence of ETC activity, Fe-S cluster biogenesis, and mitochondrial apoptosis signaling points to a cohesive theme centered on mitochondrial energy metabolism and Fe-S cluster maintenance under oxidative stress.","confidence":"High","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"members":[{"accession":"XP_041042405.1","go_terms":["GO:1904234","GO:0006879","GO:0019230","GO:0018283","GO:0046621","GO:0042542","GO:0090201","GO:0006121","GO:0010722","GO:1903329","GO:0040015","GO:0010040","GO:1904231"]},{"accession":"XP_041044930.1","go_terms":[]},{"accession":"XP_041044931.1","go_terms":[]},{"accession":"XP_041047439.1","go_terms":["GO:0045600","GO:0032981"]},{"accession":"XP_041049782.1","go_terms":["GO:0006729","GO:0006558","GO:0051289","GO:0051291","GO:0043496","GO:0006351","GO:0055114"]},{"accession":"XP_041052247.1","go_terms":["GO:0006919","GO:0090200","GO:0051402","GO:0071456"]},{"accession":"XP_041055856.1","go_terms":["GO:0017000","GO:0019380","GO:0009102","GO:0009820","GO:0009636","GO:0098869","GO:1901601","GO:0046839","GO:0019740","GO:0046272","GO:1905344","GO:0010223","GO:0019391","GO:0055114","GO:2000124","GO:0042619","GO:0097755","GO:0006212","GO:0019260","GO:0019433","GO:0042952","GO:0009086","GO:0009234","GO:1902348","GO:1990577","GO:0046718","GO:0060244","GO:0030245","GO:0001666","GO:0001662","GO:0043542","GO:0036343","GO:0035641","GO:0006508","GO:0031295","GO:0008284","GO:1902362","GO:0050796","GO:0019608","GO:0042110","GO:0007155","GO:0010716","GO:0046294","GO:0010710","GO:0097325","GO:0033632","GO:0015996","GO:0052651","GO:0006660","GO:0019373"]},{"accession":"XP_041058611.1","go_terms":["GO:0006424","GO:0006450","GO:0032543","GO:0070681"]},{"accession":"XP_041032582.1","go_terms":[]},{"accession":"XP_041034557.1","go_terms":[]},{"accession":"XP_041035183.1","go_terms":[]},{"accession":"XP_041065012.1","go_terms":["GO:0032543"]},{"accession":"XP_041068036.1","go_terms":["GO:0033119","GO:0000462","GO:0006417","GO:0006378","GO:0006412"]},{"accession":"XP_041030370.1","go_terms":["GO:0006099","GO:0055114"]},{"accession":"XP_041037337.1","go_terms":["GO:0030218","GO:0051882","GO:0032780","GO:1904925","GO:1903578","GO:1903214","GO:1901030","GO:0006783","GO:0001937"]},{"accession":"XP_041042983.1","go_terms":["GO:0055010","GO:0050684","GO:0001822","GO:0048747","GO:0001889","GO:0031426","GO:0016554","GO:0090617","GO:1905639","GO:0080156","GO:0031425","GO:0009793","GO:1900865"]},{"accession":"XP_041045054.1","go_terms":["GO:0017196"]},{"accession":"XP_041049727.1","go_terms":["GO:0033617"]},{"accession":"XP_041055558.1","go_terms":["GO:0016079","GO:0046928","GO:0006836","GO:0031915","GO:0030073"]},{"accession":"XP_041057988.1","go_terms":[]},{"accession":"XP_041061687.1","go_terms":["GO:0033615","GO:0008203"]}],"graph":[["XP_041035183.1","XP_041030370.1",0.972],["XP_041035183.1","XP_041032582.1",0.972],["XP_041035183.1","XP_041037337.1",0.976],["XP_041035183.1","XP_041034557.1",0.968],["XP_041035183.1","XP_041042405.1",0.983],["XP_041035183.1","XP_041042983.1",0.986],["XP_041035183.1","XP_041044930.1",0.952],["XP_041035183.1","XP_041044931.1",0.98],["XP_041035183.1","XP_041045054.1",0.982],["XP_041035183.1","XP_041047439.1",0.959],["XP_041035183.1","XP_041049727.1",0.989],["XP_041035183.1","XP_041049782.1",0.96],["XP_041035183.1","XP_041052247.1",0.977],["XP_041035183.1","XP_041055558.1",0.971],["XP_041035183.1","XP_041055856.1",0.961],["XP_041035183.1","XP_041057988.1",0.98],["XP_041035183.1","XP_041058611.1",0.882],["XP_041035183.1","XP_041061687.1",0.962],["XP_041035183.1","XP_041065012.1",0.979],["XP_041035183.1","XP_041068036.1",0.954],["XP_041057988.1","XP_041044930.1",0.988],["XP_041057988.1","XP_041044931.1",0.976],["XP_041057988.1","XP_041045054.1",0.984],["XP_041057988.1","XP_041047439.1",0.98],["XP_041057988.1","XP_041049727.1",0.98],["XP_041057988.1","XP_041049782.1",0.953],["XP_041057988.1","XP_041052247.1",0.959],["XP_041057988.1","XP_041055558.1",0.841],["XP_041057988.1","XP_041055856.1",0.907],["XP_041057988.1","XP_041058611.1",0.961],["XP_041057988.1","XP_041061687.1",0.968],["XP_041057988.1","XP_041068036.1",0.98],["XP_041057988.1","XP_041065012.1",0.986],["XP_041057988.1","XP_041030370.1",0.979],["XP_041057988.1","XP_041032582.1",0.959],["XP_041057988.1","XP_041034557.1",0.906],["XP_041057988.1","XP_041037337.1",0.97],["XP_041057988.1","XP_041042405.1",0.941],["XP_041057988.1","XP_041042983.1",0.965],["XP_041032582.1","XP_041030370.1",0.964],["XP_041032582.1","XP_041037337.1",0.975],["XP_041032582.1","XP_041034557.1",0.986],["XP_041032582.1","XP_041049727.1",0.951],["XP_041032582.1","XP_041049782.1",0.953],["XP_041032582.1","XP_041047439.1",0.961],["XP_041032582.1","XP_041044930.1",0.982],["XP_041032582.1","XP_041044931.1",0.989],["XP_041032582.1","XP_041045054.1",0.962],["XP_041032582.1","XP_041042983.1",0.971],["XP_041032582.1","XP_041042405.1",0.975],["XP_041032582.1","XP_041061687.1",0.835],["XP_041032582.1","XP_041058611.1",0.839],["XP_041032582.1","XP_041055558.1",0.982],["XP_041032582.1","XP_041055856.1",0.964],["XP_041032582.1","XP_041052247.1",0.985],["XP_041032582.1","XP_041068036.1",0.967],["XP_041032582.1","XP_041065012.1",0.966],["XP_041068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