{"hash":"467657263834785500","title":"Proteoglycan biosynthesis and sulfation","description":"The cluster is dominated by glycosaminoglycan/proteoglycan-related processes: heparan proteoglycan and chondroitin sulfate biosynthesis, N-acetylglucosamine metabolism, and enzymatic modification of heparan sulfate proteoglycans, plus sulfate assimilation. This suggests a cohesive theme of proteoglycan assembly and sulfation, with related carbohydrate pathways contributing to the shared metabolism. Some other terms like xenobiotic and thyroid hormone metabolism may reflect broader, overlapping enzyme activities but do not override the proteoglycan biosynthesis signal.","confidence":"High","size":26,"edges":68,"triangles":91,"max_degree":15,"top_function":"regulation of DNA-templated transcription","members":[{"accession":"XP_029843222.2","go_terms":["GO:0051603","GO:0050790","GO:0097067","GO:0001957","GO:0010815","GO:0010813","GO:0030574","GO:2000179","GO:0001913","GO:0060441","GO:0034769","GO:0060448","GO:0046697","GO:0045453","GO:0035593","GO:2001235","GO:0006508","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418"]},{"accession":"XP_029849449.2","go_terms":["GO:0051603","GO:0050790","GO:0097067","GO:0001957","GO:0010815","GO:0010813","GO:0030574","GO:2000179","GO:0001913","GO:0060441","GO:0034769","GO:0060448","GO:0046697","GO:0045453","GO:0035593"]},{"accession":"XP_002435711.1","go_terms":["GO:1902600","GO:0097250","GO:0006123","GO:0009060"]},{"accession":"XP_029835876.2","go_terms":["GO:0030324","GO:0017000","GO:0046677","GO:0042574","GO:0009710","GO:0045150","GO:0006729","GO:0042438","GO:0008207","GO:0055114","GO:0071768","GO:0042619","GO:0031427","GO:0030497","GO:0006355","GO:0008209","GO:0030148","GO:0006710","GO:0042572","GO:0042761","GO:0042376","GO:0006666","GO:0006704","GO:0006703","GO:0002138","GO:0061370","GO:0006706","GO:0030435","GO:0042208","GO:1902321"]},{"accession":"XP_029838653.1","go_terms":["GO:0030324","GO:0017000","GO:0046677","GO:0042574","GO:0009710","GO:0045150","GO:0006729","GO:0042438","GO:0008207","GO:0055114","GO:0071768","GO:0042619","GO:0031427","GO:0030497","GO:0006355","GO:0008209","GO:0030148","GO:0006710","GO:0042572","GO:0042761","GO:0042376","GO:0006666","GO:0006704","GO:0006703","GO:0002138","GO:0061370","GO:0006706","GO:0030435","GO:0042208","GO:1902321"]},{"accession":"XP_029838654.1","go_terms":["GO:0030324","GO:0017000","GO:0046677","GO:0042574","GO:0009710","GO:0045150","GO:0006729","GO:0042438","GO:0008207","GO:0055114","GO:0071768","GO:0042619","GO:0031427","GO:0030497","GO:0006355","GO:0008209","GO:0030148","GO:0006710","GO:0042572","GO:0042761","GO:0042376","GO:0006666","GO:0006704","GO:0006703","GO:0002138","GO:0061370","GO:0006706","GO:0030435","GO:0042208","GO:1902321"]},{"accession":"XP_029845273.2","go_terms":["GO:0017004","GO:0006099","GO:0009060","GO:0006121"]},{"accession":"XP_040077730.2","go_terms":["GO:0030324","GO:0017000","GO:0046677","GO:0042574","GO:0009710","GO:0045150","GO:0006729","GO:0042438","GO:0008207","GO:0055114","GO:0071768","GO:0042619","GO:0031427","GO:0030497","GO:0006355","GO:0008209","GO:0030148","GO:0006710","GO:0042572","GO:0042761","GO:0042376","GO:0006666","GO:0006704","GO:0006703","GO:0002138","GO:0061370"]},{"accession":"XP_029850216.3","go_terms":["GO:0048575","GO:0030154","GO:0060409","GO:0042755","GO:0010229","GO:0010951","GO:0048240","GO:0007275","GO:0009911","GO:0009910","GO:0048510","GO:0009908"]},{"accession":"XP_029829104.1","go_terms":["GO:0030324","GO:0017000","GO:0046677","GO:0042574","GO:0009710","GO:0045150","GO:0006729","GO:0042438","GO:0008207","GO:0055114","GO:0071768","GO:0042619","GO:0031427","GO:0030497","GO:0006355","GO:0008209","GO:0030148","GO:0006710","GO:0042572","GO:0042761","GO:0042376","GO:0006666","GO:0006704","GO:0006703","GO:0002138","GO:0061370","GO:0006706","GO:0030435","GO:0042208","GO:1902321"]},{"accession":"XP_002399230.2","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]},{"accession":"XP_042148631.1","go_terms":["GO:0010205","GO:0070542","GO:0050872","GO:1903699","GO:0034435","GO:1903966","GO:0010873","GO:0046512","GO:0033561","GO:0044130","GO:0006667"]},{"accession":"XP_002411989.3","go_terms":["GO:0010205","GO:0070542","GO:0050872","GO:1903699","GO:0034435","GO:1903966","GO:0010873","GO:0046512","GO:0033561","GO:0044130","GO:0006667"]},{"accession":"XP_002411990.3","go_terms":["GO:0010205","GO:0070542","GO:0050872","GO:1903699","GO:0034435","GO:1903966","GO:0010873","GO:0046512","GO:0033561","GO:0044130","GO:0006667"]},{"accession":"XP_002435072.1","go_terms":["GO:0010205","GO:0070542","GO:0050872","GO:1903699","GO:0034435","GO:1903966","GO:0010873","GO:0046512","GO:0033561","GO:0044130","GO:0006667"]},{"accession":"XP_040067226.3","go_terms":["GO:0010205","GO:0070542","GO:0050872","GO:1903699","GO:0034435","GO:1903966","GO:0010873","GO:0046512","GO:0033561","GO:0044130","GO:0006667"]},{"accession":"XP_002407494.4","go_terms":["GO:0006478","GO:0030206","GO:0030205","GO:0006044","GO:0018146","GO:0006711","GO:0006477","GO:0006805","GO:0042403","GO:0000103","GO:0002002","GO:0045600","GO:0030210","GO:0048702","GO:0006584","GO:0050427","GO:0030573","GO:0009812","GO:0015012","GO:0015015","GO:0006068"]},{"accession":"XP_029831116.2","go_terms":["GO:0006478","GO:0030206","GO:0030205","GO:0006044","GO:0018146","GO:0006711","GO:0006477","GO:0006805","GO:0042403","GO:0000103","GO:0002002","GO:0045600","GO:0030210","GO:0048702","GO:0006584","GO:0050427","GO:0030573","GO:0009812","GO:0015012","GO:0015015","GO:0006068"]},{"accession":"XP_029832274.2","go_terms":["GO:0006478","GO:0030206","GO:0030205","GO:0006044","GO:0018146","GO:0006711","GO:0006477","GO:0006805","GO:0042403","GO:0000103","GO:0002002","GO:0045600","GO:0030210","GO:0048702","GO:0006584","GO:0050427","GO:0030573","GO:0009812","GO:0015012","GO:0015015","GO:0006068"]},{"accession":"XP_029839482.3","go_terms":["GO:0030206","GO:0030205","GO:0006044","GO:0018146","GO:0006711","GO:0006477","GO:0006805","GO:0042403","GO:0000103","GO:0002002","GO:0045600","GO:0030210","GO:0048702","GO:0006584","GO:0050427","GO:0030573","GO:0009812","GO:0015012","GO:0015015","GO:0006068"]},{"accession":"XP_002403975.2","go_terms":["GO:0010205","GO:0070542","GO:0050872","GO:1903699","GO:0034435","GO:1903966","GO:0010873","GO:0046512","GO:0033561","GO:0044130","GO:0006667","GO:0007053","GO:0046513"]},{"accession":"XP_002402467.3","go_terms":["GO:0006478","GO:0030206","GO:0030205","GO:0006044","GO:0018146","GO:0006711","GO:0006477","GO:0006805","GO:0042403","GO:0000103","GO:0002002","GO:0045600","GO:0030210","GO:0048702","GO:0006584","GO:0050427","GO:0030573","GO:0009812","GO:0015012","GO:0015015","GO:0006068"]},{"accession":"XP_029832956.3","go_terms":["GO:0030206","GO:0030205","GO:0006044","GO:0018146","GO:0006711","GO:0006477","GO:0006805","GO:0042403","GO:0000103","GO:0002002","GO:0045600","GO:0030210","GO:0048702","GO:0006584","GO:0050427","GO:0030573","GO:0009812","GO:0015012","GO:0015015","GO:0006068"]},{"accession":"XP_040071780.1","go_terms":["GO:0030206","GO:0030205","GO:0006044","GO:0018146","GO:0006711","GO:0006477","GO:0006805","GO:0042403","GO:0000103","GO:0002002","GO:0045600","GO:0030210","GO:0048702","GO:0006584","GO:0050427","GO:0030573","GO:0009812","GO:0015012","GO:0015015","GO:0006068"]},{"accession":"XP_040064226.1","go_terms":[]},{"accession":"XP_040070068.2","go_terms":["GO:0042395","GO:1903779","GO:0032800","GO:0060177","GO:0060047","GO:0042447","GO:0003051","GO:0002003","GO:0046813","GO:0002005","GO:2000170","GO:0061098","GO:1902033","GO:1900086","GO:0045938","GO:0071838","GO:0015827","GO:0007289","GO:0002446","GO:0009609","GO:0003084","GO:1903597","GO:0060452","GO:1903598"]}],"graph":[["XP_040077730.2","XP_042148631.1",0.761],["XP_040077730.2","XP_002411989.3",0.62],["XP_040077730.2","XP_002411990.3",0.677],["XP_040077730.2","XP_002435072.1",0.949],["XP_040077730.2","XP_029845273.2",0.571],["XP_029850216.3","XP_042148631.1",0.679],["XP_029850216.3","XP_002411989.3",0.646],["XP_029850216.3","XP_002411990.3",0.676],["XP_029850216.3","XP_002435072.1",0.75],["XP_029838653.1","XP_042148631.1",0.884],["XP_029838653.1","XP_002411989.3",0.704],["XP_029838653.1","XP_002411990.3",0.847],["XP_029838653.1","XP_002435072.1",0.719],["XP_029838653.1","XP_029829104.1",0.727],["XP_029838653.1","XP_029838654.1",0.751],["XP_002411989.3","XP_002399230.2",0.764],["XP_002411989.3","XP_002411990.3",0.845],["XP_002411989.3","XP_002435072.1",0.745],["XP_002411989.3","XP_002435711.1",0.726],["XP_002411989.3","XP_029829104.1",0.902],["XP_002411989.3","XP_029835876.2",0.812],["XP_002411989.3","XP_029838654.1",0.834],["XP_002411989.3","XP_029843222.2",0.546],["XP_002411989.3","XP_029849449.2",0.547],["XP_002411989.3","XP_040064226.1",0.746],["XP_002411989.3","XP_040070068.2",0.7],["XP_002411989.3","XP_042148631.1",0.862],["XP_002403975.2","XP_002399230.2",0.733],["XP_002403975.2","XP_002435711.1",0.549],["XP_002403975.2","XP_029835876.2",0.63],["XP_002403975.2","XP_040070068.2",0.603],["XP_040064226.1","XP_002435072.1",0.689],["XP_029843222.2","XP_042148631.1",0.506],["XP_029843222.2","XP_002399230.2",0.659],["XP_029843222.2","XP_002411990.3",0.511],["XP_029843222.2","XP_002435072.1",0.667],["XP_042148631.1","XP_029838654.1",0.852],["XP_042148631.1","XP_029849449.2",0.5],["XP_042148631.1","XP_002399230.2",0.623],["XP_042148631.1","XP_002411990.3",0.873],["XP_042148631.1","XP_002435072.1",0.729],["XP_042148631.1","XP_002435711.1",0.816],["XP_042148631.1","XP_029829104.1",0.927],["XP_042148631.1","XP_029835876.2",0.787],["XP_040071780.1","XP_002407494.4",0.679],["XP_002435072.1","XP_002399230.2",0.748],["XP_002435072.1","XP_002411990.3",0.817],["XP_002435072.1","XP_029835876.2",0.789],["XP_002435072.1","XP_029829104.1",0.914],["XP_002435072.1","XP_002435711.1",0.805],["XP_002435072.1","XP_029849449.2",0.554],["XP_002435072.1","XP_029838654.1",0.908],["XP_002435072.1","XP_040070068.2",0.572],["XP_029835876.2","XP_002411990.3",0.679],["XP_029835876.2","XP_029845273.2",0.579],["XP_002399230.2","XP_002411990.3",0.711],["XP_002399230.2","XP_029849449.2",0.727],["XP_040067226.3","XP_002411990.3",0.596],["XP_040067226.3","XP_002435711.1",0.503],["XP_040067226.3","XP_029829104.1",0.787],["XP_040067226.3","XP_029838654.1",0.58],["XP_029838654.1","XP_002411990.3",0.787],["XP_029838654.1","XP_029829104.1",0.531],["XP_029845273.2","XP_002411990.3",0.558],["XP_029845273.2","XP_002435711.1",0.577],["XP_029845273.2","XP_029829104.1",0.899],["XP_002411990.3","XP_002435711.1",0.79],["XP_002411990.3","XP_029829104.1",0.847]],"all_go_terms":{"GO:0060448":3,"GO:0010815":3,"GO:0034769":3,"GO:2000179":3,"GO:0045453":3,"GO:0060441":3,"GO:0009636":2,"GO:0050790":3,"GO:0030574":3,"GO:0097067":3,"GO:0001913":3,"GO:1990236":2,"GO:0042493":2,"GO:0001957":3,"GO:2001235":1,"GO:1990237":2,"GO:0051603":3,"GO:0046697":3,"GO:0043418":2,"GO:0006508":2,"GO:0035593":3,"GO:0010813":3,"GO:0006123":1,"GO:0097250":1,"GO:0009060":2,"GO:1902600":1,"GO:0006355":5,"GO:1902321":4,"GO:0006706":4,"GO:0006729":5,"GO:0045150":5,"GO:0030497":5,"GO:0042208":4,"GO:0071768":5,"GO:0006666":5,"GO:0042574":5,"GO:0006703":5,"GO:0042619":5,"GO:0046677":5,"GO:0009710":5,"GO:0030148":5,"GO:0055114":5,"GO:0042572":5,"GO:0042438":5,"GO:0017000":5,"GO:0006704":5,"GO:0006710":5,"GO:0042376":5,"GO:0030435":4,"GO:0008207":5,"GO:0008209":5,"GO:0002138":5,"GO:0030324":5,"GO:0061370":5,"GO:0042761":5,"GO:0031427":5,"GO:0017004":1,"GO:0006099":1,"GO:0006121":1,"GO:0048510":1,"GO:0060409":1,"GO:0009908":1,"GO:0042755":1,"GO:0048575":1,"GO:0010951":1,"GO:0010229":1,"GO:0048240":1,"GO:0009910":1,"GO:0030154":1,"GO:0007275":1,"GO:0009911":1,"GO:1903955":1,"GO:0043129":1,"GO:0010839":1,"GO:0007614":1,"GO:1903146":1,"GO:0071888":1,"GO:0044130":6,"GO:1903966":6,"GO:0010873":6,"GO:0046512":6,"GO:0033561":6,"GO:1903699":6,"GO:0050872":6,"GO:0034435":6,"GO:0010205":6,"GO:0070542":6,"GO:0006667":6,"GO:0000103":7,"GO:0030210":7,"GO:0030206":7,"GO:0009812":7,"GO:0042403":7,"GO:0045600":7,"GO:0006044":7,"GO:0002002":7,"GO:0006805":7,"GO:0015015":7,"GO:0030205":7,"GO:0006584":7,"GO:0050427":7,"GO:0006477":7,"GO:0006068":7,"GO:0006711":7,"GO:0015012":7,"GO:0018146":7,"GO:0006478":4,"GO:0030573":7,"GO:0048702":7,"GO:0007053":1,"GO:0046513":1,"GO:0042395":1,"GO:0061098":1,"GO:0003084":1,"GO:0060452":1,"GO:2000170":1,"GO:0003051":1,"GO:1903779":1,"GO:0002003":1,"GO:0009609":1,"GO:1900086":1,"GO:0007289":1,"GO:0015827":1,"GO:0060177":1,"GO:0045938":1,"GO:0032800":1,"GO:0046813":1,"GO:0042447":1,"GO:0002446":1,"GO:1903597":1,"GO:1903598":1,"GO:0060047":1,"GO:0002005":1,"GO:0071838":1,"GO:1902033":1},"recipe_readded":[]}