[{"hash":"693341092825258034","title":"Lipid metabolism and wax biosynthesis","description":"This cluster is dominated by lipid-related processes: lipid storage, diacylglycerol biosynthesis, ceramide metabolism, long-chain fatty-acyl-CoA metabolism, acyl-glycerol remodeling, and wax biosynthesis, plus phytol metabolism and fat-related development terms. Together these point to lipid storage and the synthesis/handling of lipid-based structures such as waxes and membrane lipids, which is a cohesive theme for the proteins in this cluster. Some terms like infection structure formation and LDL particle clearance are broader lipid-associated processes but do not override the central lipid metabolism focus.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019915","count":4},{"id":"GO:0075015","count":3},{"id":"GO:0006651","count":3},{"id":"GO:0060613","count":3},{"id":"GO:0006672","count":3}]},{"hash":"1223520583953772298","title":"Ubiquitin-Proteasome Regulation and Cell Cycle","description":"Cluster is centered on ubiquitin-dependent proteolysis and proteasome-mediated protein degradation, with SCF ligase activity and protein polyubiquitination; these processes underpin cell-cycle control and DNA damage checkpoints, consistent with the included mitotic G1 checkpoint signaling and proliferation regulation. Cadmium ion response aligns with metal stress\u2013induced proteostasis. The neural development and circadian rhythm terms likely reflect broader roles of ubiquitin signaling in development and rhythmic biology, but the dominant theme remains protein turnover and cell-cycle regulation.","confidence":"Medium","size":29,"edges":92,"triangles":59,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0071276","count":11},{"id":"GO:0042787","count":11},{"id":"GO:0031146","count":11},{"id":"GO:1902916","count":10},{"id":"GO:0031571","count":10}]},{"hash":"1112094008101141949","title":"Stress-Responsive Transcription and Development","description":"The cluster centers on DNA-templated transcription and includes multiple stress-related responses (cocaine, immobilization, LPS) along with diverse developmental processes (fat cell differentiation, cartilage growth, face and vaginal development). This suggests a group of transcriptional regulators that link stress signaling to developmental pathways.","confidence":"Medium","size":29,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":13},{"id":"GO:0042220","count":12},{"id":"GO:0035902","count":11},{"id":"GO:0071222","count":10},{"id":"GO:0045444","count":9}]},{"hash":"344584181994480773","title":"Energy metabolism and insulin signaling","description":"The GO terms point to metabolic regulation, nutrient sensing, and hormonal control, with emphasis on insulin signaling, energy expenditure (adaptive thermogenesis), mitochondrial function, and responses to nutrient stress (amino acid starvation). While there is breadth (including liver regeneration and pregnancy-related signals), the common theme is energy homeostasis and metabolic signaling, so this label captures the cluster's overall function.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0034198","count":5},{"id":"GO:0051881","count":5},{"id":"GO:0051291","count":4},{"id":"GO:1990845","count":4}]},{"hash":"118809592306480002","title":"Glycosaminoglycan biosynthesis and sulfation","description":"The top terms are dominated by glycosaminoglycan-related biosynthesis and sulfation, including heparan sulfate and chondroitin sulfate proteoglycan biosynthesis, N-acetylglucosamine metabolism, and sulfate assimilation. This points to a coherent theme of GAG construction and sulfation pathways, with enzymatic modification of proteoglycans being central.","confidence":"High","size":29,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000103","count":12},{"id":"GO:0030210","count":11},{"id":"GO:0030206","count":11},{"id":"GO:0009812","count":11},{"id":"GO:0042403","count":11}]},{"hash":"1396232263810516263","title":"Proviral DNA integration and transposition","description":"The top GO terms center on DNA integration, recombination, and transposition, including establishment of integrated proviral latency, which points to mobilome activity such as retroviral or transposable element integration into host genomes. Some terms about symbiont entry or xenobiotic response appear but are less central; the core theme is genome integration/transposition related to proviral latency. High","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0006310","count":5},{"id":"GO:0075713","count":5},{"id":"GO:0039651","count":5},{"id":"GO:2000327","count":4}]},{"hash":"2171454756795614725","title":"Larval chitin-based cuticle development","description":"Dominant GO term is larval chitin-based cuticle development (GO:0008363) with 23 proteins, indicating most proteins are linked to insect larval exoskeleton formation. The remaining terms are few and diverse, suggesting incidental annotations rather than a cohesive secondary function. Therefore this cluster is best described as a larval cuticle development group.","confidence":"High","size":29,"edges":336,"triangles":2471,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":23},{"id":"GO:0006067","count":1},{"id":"GO:0061668","count":1},{"id":"GO:0061028","count":1},{"id":"GO:0070941","count":1}]},{"hash":"1518912969282632142","title":"MVB-mediated protein sorting and vesicle trafficking","description":"The Top Terms cluster around endosomal-to-vacuole sorting via the multivesicular body (MVB) pathway, including MVB assembly, transport to the vacuole, and ubiquitin-dependent sorting, plus related ER targeting and endosome regulation; additional terms touch on cell division-related remodeling (abscission, exit from mitosis) and apoptotic processes. Together, these indicate a cohesive theme of vesicle trafficking and MVB-mediated protein sorting within the endomembrane system.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904669","count":2},{"id":"GO:0030447","count":2},{"id":"GO:0010458","count":2},{"id":"GO:0036258","count":2},{"id":"GO:0043328","count":2}]},{"hash":"1830046817488687675","title":"Nuclear gene expression and RNA processing","description":"The top GO terms cluster around nuclear gene expression: transcription, splicing, and ribosome biogenesis, with several development terms suggesting tissue-specific regulation. The shared theme is core gene expression machinery linked to cellular growth and development, despite some broader/obsolete terms. Thus \"Nuclear gene expression and RNA processing\" is a fitting label.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043486","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0072520","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0060041","count":2}]},{"hash":"1725553992336995087","title":"Postsynaptic organization and neurotransmission","description":"The cluster\u2019s top GO terms cluster around postsynaptic assembly, gephyrin clustering, and regulation of postsynaptic potentials, with supporting terms on active-zone cytoskeletal organization. This points to a cohesive theme of synapse structure and signaling, rather than broad developmental processes. Some terms like retina development and osteoblast development may reflect broader developmental annotations or pleiotropy, but the dominant signal is postsynaptic organization and neurotransmission.","confidence":"High","size":29,"edges":148,"triangles":206,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0002076","count":10},{"id":"GO:0002087","count":9},{"id":"GO:0060041","count":9},{"id":"GO:0042493","count":9},{"id":"GO:0008285","count":7}]},{"hash":"848954136843792865","title":"Inflammation-Driven Vascular Remodeling","description":"The top GO terms show a coherent signature of inflammation and tissue remodeling: immune signaling (complement activation, response to lipopolysaccharide, leukocyte tethering/rolling) and extracellular matrix dynamics (positive regulation of angiogenesis, elastin catabolic process, regulation of cell-matrix adhesion). A few terms such as midbrain development and transcription regulation are less aligned, but the dominant pattern points to proteins involved in inflammatory vascular remodeling rather than a single developmental or metabolic process.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030901","count":7},{"id":"GO:0000122","count":7},{"id":"GO:1902947","count":6},{"id":"GO:1903238","count":6},{"id":"GO:2000097","count":6}]},{"hash":"698263953437885003","title":"Embryonic tissue development across organs","description":"This cluster centers on developmental and morphogenetic processes across several tissues (endothelial proliferation, Sertoli cell development, male gonad development, lacrimal gland development, digestive tract morphogenesis) with supporting terms for stem cell proliferation and gene regulation, suggesting a broad embryonic development role rather than a single-tissue function. ","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":3},{"id":"GO:0006313","count":2},{"id":"GO:0060009","count":2},{"id":"GO:0032425","count":2},{"id":"GO:0006351","count":2}]},{"hash":"2092355695640100690","title":"Embryonic organogenesis and patterning","description":"The GO terms show a concentration on developmental processes across multiple tissues\u2014heart and cartilage morphogenesis, left-right patterning, endocardial cushion EMT, endocrine and pancreatic development, and placental-related differentiation. While there is some diversity (including immune signaling), the common thread is embryonic organogenesis and tissue morphogenesis, supporting a label that emphasizes developmental patterning rather than a single pathway. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035621","count":2},{"id":"GO:0003007","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0003198","count":2}]},{"hash":"25562748220743233","title":"Hematopoietic lineage differentiation","description":"The cluster is strongly enriched for terms related to blood cell differentiation across lineages (granulocytes, erythrocytes, megakaryocytes) and maintenance of somatic stem cells, with connections to embryonic development and vascular morphogenesis. This pattern suggests a cohesive module governing hematopoiesis and early developmental processes, rather than unrelated pathways.","confidence":"High","size":29,"edges":36,"triangles":5,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030851","count":13},{"id":"GO:0045648","count":13},{"id":"GO:0000122","count":12},{"id":"GO:0043046","count":10},{"id":"GO:0045654","count":9}]},{"hash":"856142524064113367","title":"AGP Glycosylation and Root Hair Development","description":"These proteins cluster around arabinogalactan protein (AGP) metabolism and hydroxyproline O-glycosylation, with links to root hair formation, seed coat mucilage, and cell adhesion, pointing to a plant extracellular matrix/glycoprotein biosynthesis function.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0080147","count":4},{"id":"GO:0042248","count":4},{"id":"GO:0048354","count":4},{"id":"GO:0010405","count":4},{"id":"GO:0001744","count":4}]},{"hash":"615180765506897242","title":"Cytochrome P450\u2013driven lipid and hormone biosynthesis","description":"The top GO terms cluster around lipid and hormone metabolism\u2014prostaglandin biosynthesis, calcitriol activation, omega-hydroxylase and epoxygenase P450 pathways, and triglyceride metabolism\u2014pointing to cytochrome P450\u2013mediated processing of lipids and steroidal compounds; developmental terms like sex differentiation and maternal parturition align with hormone signaling, supporting a cohesive P450 lipid/hormone theme despite a few outliers.","confidence":"High","size":29,"edges":9,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0046232","count":27},{"id":"GO:0060736","count":26},{"id":"GO:0033072","count":26},{"id":"GO:0036378","count":26},{"id":"GO:0097267","count":26}]},{"hash":"357487700545466594","title":"Transmembrane sugar and xenobiotic transport","description":"Most terms describe transmembrane transport of vitamins, xenobiotics, and sugars (glucose/fructose), along with associated nutrient uptake and sugar-response processes; the intestinal maintenance term aligns with absorptive transporter roles. This points to a cohesive set of membrane transport proteins handling sugars and xenobiotics.","confidence":"High","size":29,"edges":155,"triangles":172,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":27},{"id":"GO:0006855","count":27},{"id":"GO:0042908","count":23},{"id":"GO:1904659","count":22},{"id":"GO:0042149","count":22}]},{"hash":"1425987125098880024","title":"DNA replication and viral-host entry cluster","description":"This cluster is centered on DNA replication, recombination, and cell division, indicating core genome maintenance and cell-cycle guidance. It also features viral-host interaction terms (proviral latency, host nuclear entry/penetration) alongside bacterial metabolism signals, suggesting a cohesive group of proteins linked to genome maintenance with viral integration/entry aspects. ","confidence":"Medium","size":29,"edges":18,"triangles":8,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0009234","count":5},{"id":"GO:0046677","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0010124","count":4}]},{"hash":"1107083944990594434","title":"Retroviral entry, replication, and genome integration","description":"This cluster centers on GO terms for viral entry into host cells, nuclear penetration, DNA replication, DNA integration, and establishment of proviral latency, plus RNA-templated DNA biosynthesis, which aligns with retrovirus/integating viral life cycles and provirus maintenance. The presence of immune-evasion terms (negative regulation of siRNA processing) further supports a viral infection theme.","confidence":"High","size":29,"edges":140,"triangles":174,"max_degree":18,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":21},{"id":"GO:0046718","count":19},{"id":"GO:0075732","count":19},{"id":"GO:0006260","count":19},{"id":"GO:0075713","count":19}]},{"hash":"1097665800673516822","title":"Virus entry, latency establishment, and DNA repair","description":"This cluster combines GO terms tied to viral processes (symbiont/viral entry into host cell, viral penetration into the nucleus, establishment of integrated proviral latency) with host genome maintenance activities (DNA recombination, base-excision repair). It also includes related regulatory processes like RNA interference suppression and cell-cycle modulation, all pointing to a cohesive theme of virus\u2013host genome interaction and manipulation of DNA repair pathways during infection. Some terms (e.g., xenobiotic response) reflect broad stress responses that can accompany infection, but the dominant pattern supports the viral entry/latency and DNA repair connection.","confidence":"High","size":29,"edges":26,"triangles":2,"max_degree":12,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":16},{"id":"GO:0090502","count":10},{"id":"GO:0006284","count":9},{"id":"GO:0042493","count":9},{"id":"GO:1900087","count":9}]},{"hash":"650560587637901416","title":"Diverse tissue development","description":"The top GO terms point to a range of tissue- and organ-specific development and differentiation processes (pituitary gland, osteoblast, midbrain, granulocyte, glial cell, erythrocyte, roof of mouth, uterus development), with a broad regulatory term also present. There isn't a single cohesive pathway or process linking all terms, suggesting the cluster encompasses proteins involved in multiple developmental/differentiation contexts across different tissues.","confidence":"Medium","size":29,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0055114","count":8},{"id":"GO:0021983","count":7},{"id":"GO:0002076","count":6},{"id":"GO:0030901","count":6}]},{"hash":"215522850583594651","title":"Retroviral integration and latency","description":"This cluster\u2019s top GO terms center on establishment of integrated proviral latency, DNA integration, and reverse transcription (RNA-templated DNA biosynthesis), alongside processes related to viral entry and nuclear penetration. The collection of terms maps well to the retroviral life cycle: entry into the host, reverse transcription of RNA into DNA, followed by integration of viral DNA into the host genome and latency. Confidence: High","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075713","count":9},{"id":"GO:0015074","count":9},{"id":"GO:0039651","count":9},{"id":"GO:0006310","count":8},{"id":"GO:0046718","count":8}]},{"hash":"1288018211326723255","title":"Proviral integration and latency","description":"GO terms such as establishment of integrated proviral latency and DNA integration point to a core theme of viral genome integration into the host and maintenance of latency. Additional terms like symbiont entry into host cells and viral penetration into the host nucleus reinforce a viral entry/integration narrative, while DNA recombination, DNA transposition, and RNA-templated DNA biosynthesis echo mechanisms used by retroelements and mobile genetic elements. Taken together, these terms suggest a cluster centered on proviral integration and latency, with related genome-integration processes.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075713","count":9},{"id":"GO:0039651","count":9},{"id":"GO:0015074","count":9},{"id":"GO:0046718","count":8},{"id":"GO:0075732","count":8}]},{"hash":"814239133364690794","title":"DNA Mobility and Proviral Integration","description":"The top GO terms cluster around DNA recombination, transposition, and integration, plus RNA-templated DNA biosynthesis (reverse transcription) and proviral latency/viral entry concepts. This suggests a core theme of mobility and integration of genetic elements (transposons, retroelements) and associated viral/proviral processes, justifying the label.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":4},{"id":"GO:0006278","count":4},{"id":"GO:0006355","count":3},{"id":"GO:0090502","count":3},{"id":"GO:0006313","count":3}]},{"hash":"1225772958989933717","title":"Neuronal development and synaptic signaling","description":"The top GO terms cluster around brain development, neurotransmitter secretion, calcium-dependent exocytosis, and neuron survival, pointing to neural development and synaptic transmission as the core theme. Additional terms on GTPase regulation, endocytic recycling, and growth reflect related signaling and trafficking processes that accompany neuronal function; a few outliers like cardiac muscle contraction are present but do not override the neural-centric pattern.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0007269","count":3},{"id":"GO:0043524","count":3},{"id":"GO:0045956","count":3},{"id":"GO:0045792","count":3}]},{"hash":"1041271300504447905","title":"Ubiquitin-mediated NF-\u03baB innate immune signaling","description":"These proteins cluster around ubiquitin-dependent protein turnover and innate antiviral signaling, with terms for autoubiquitination, ERAD-related processes, and activation of NF-\u03baB pathways (IKK/I\u03baB regulation, TNF signaling, defense against virus). The common theme is ubiquitin-driven regulation of innate immune responses via NF-\u03baB.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0045087","count":5},{"id":"GO:0051865","count":5},{"id":"GO:0030433","count":4},{"id":"GO:0051607","count":4}]},{"hash":"2097577877363965745","title":"Vertebrate Development and Signaling","description":"The top GO terms point to tissue- and organism-level development (forebrain, skeletal system, skin, multicellular organism development) coupled with signaling regulation (GTPase activity, protein kinases, serine/threonine phosphorylation) and cell cycle processes, suggesting a cluster of proteins involved in coordinating developmental signaling and proliferation in vertebrates.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0051028","count":6},{"id":"GO:0031954","count":6}]},{"hash":"2241892754471483671","title":"Lipid and cholesterol metabolism with lipoprotein remodeling","description":"The top GO terms point to triglyceride catabolic and biosynthetic processes, lipid digestion, cholesterol homeostasis, and remodeling of lipoprotein particles (HDL/VLDL), along with reverse cholesterol transport and intestinal cholesterol absorption, indicating a cohesive theme of lipid processing and cholesterol transport. While a couple of biosynthetic terms (biotin, antibiotic biosynthesis) appear, the dominant signal is lipid and cholesterol metabolism and lipoprotein remodeling.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":11},{"id":"GO:0017000","count":9},{"id":"GO:0009102","count":7},{"id":"GO:0044241","count":7},{"id":"GO:0034375","count":7}]},{"hash":"1266493612851626042","title":"Embryonic development and organogenesis","description":"The dominant GO terms describe developmental processes across multiple organs (endocrine system development, placenta and pancreatic cell development, cartilage morphogenesis, heart/endocardial cushion EMT, left-right pattern formation, and trophoblast differentiation). This points to a cohesive theme of embryonic development and organ formation, with a couple of outliers that are less central to the cluster.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0003323","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0003198","count":4}]},{"hash":"1569812598588496957","title":"Unknown","description":"The top terms span DNA replication, vesicle transport, fungal ascospore formation, multiple differentiation pathways (lung epithelium, neurons), xenobiotic and drug responses, and unfolded protein response, with no clear shared function or pathway linking most items. The small number of edges and lack of a unifying process suggest a heterogeneous cluster rather than a single biological theme.","confidence":"","size":28,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":10},{"id":"GO:0006888","count":8},{"id":"GO:0030437","count":8},{"id":"GO:0060487","count":8},{"id":"GO:0035690","count":8}]},{"hash":"1037628336144012164","title":"Neuroinflammation and vascular signaling","description":"GO terms converge on inflammatory responses (inflammatory response, chemokine production), vascular-related processes (blood coagulation, transforming growth factor beta production), nitric oxide biosynthesis, oxidative detoxification, and cell adhesion. The inclusion of a neural migration term suggests a brain-related context, supporting a theme of neuroinflammatory and vascular remodeling signaling. Confidence: Medium","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":6},{"id":"GO:0090197","count":6},{"id":"GO:0045429","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0006954","count":5}]},{"hash":"1925804084688046061","title":"DNA replication and telomere maintenance","description":"This cluster is dominated by GO terms for DNA replication (DNA replication, leading strand elongation, error-free translesion synthesis) and telomere biology (telomere maintenance via telomerase, telomere capping), with supporting signals from cell-cycle and genome integrity processes (centrosome cycle, apoptosis). The combination suggests proteins functioning together in DNA replication and genome stability rather than disparate roles.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":8},{"id":"GO:0006915","count":4},{"id":"GO:0032212","count":4},{"id":"GO:0070987","count":3},{"id":"GO:0006272","count":3}]},{"hash":"1383104425833348257","title":"Peroxisomal fatty acid beta-oxidation","description":"The cluster is enriched for peroxisomal lipid catabolism, highlighted by fatty acid beta-oxidation (acyl-CoA oxidase) and carnitine-linked metabolism, with related energy/lipid terms like starvation response and steroid biosynthesis; other terms appear as noise, and there are no edges indicating direct interactions.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033540","count":4},{"id":"GO:0019254","count":4},{"id":"GO:0042594","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0055114","count":3}]},{"hash":"1839997763728235769","title":"Larval chitin-based cuticle development","description":"The only prominent GO term points to larval chitin-based cuticle development, suggesting the cluster is centered on proteins involved in forming the larval cuticle via chitin biosynthesis or remodeling. With no broader shared terms available, the label captures the strongest signal, but the limited annotation supports only moderate confidence.","confidence":"Medium","size":28,"edges":111,"triangles":304,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1}]},{"hash":"1065923383194872996","title":"Transmembrane transport of nutrients and ions","description":"Top GO terms show multiple transmembrane transport activities for small molecules and ions (myo-inositol, pantothenate, biotin, glucose) and ions (sodium, potassium), indicating a cluster of membrane transport proteins facilitating uptake and ion homeostasis. While there are inflammatory signaling terms present, they likely reflect context-dependent responses rather than the primary function. Overall, the core theme is transmembrane nutrient and ion transport.","confidence":"High","size":28,"edges":65,"triangles":8,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0015798","count":2},{"id":"GO:0015887","count":2},{"id":"GO:0008292","count":2},{"id":"GO:0071436","count":2},{"id":"GO:0015878","count":2}]},{"hash":"1430244111494378699","title":"Adhesion and ECM remodeling in development","description":"Top GO terms cluster around integrin-mediated cell adhesion, EMT in heart development, and ECM-related processes (proteoglycan catabolic process), with associated cell migration and growth factor signaling regulation. This points to a cohesive theme of cell-matrix interactions guiding development and tissue remodeling, including immune cell movement. ","confidence":"Medium","size":28,"edges":41,"triangles":15,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0033630","count":4},{"id":"GO:0008363","count":3},{"id":"GO:0007155","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0045636","count":2}]},{"hash":"1278287379278608969","title":"RNA Splicing and Processing Regulation","description":"The Term set centers on spliceosome-mediated mRNA splicing and its regulation, along with related RNA maturation steps (polyadenylation tail processing and snoRNP assembly), pointing to a functional cluster of proteins involved in RNA processing and gene expression control.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":2},{"id":"GO:0000493","count":1},{"id":"GO:1904874","count":1},{"id":"GO:2000233","count":1},{"id":"GO:0045292","count":1}]},{"hash":"1259627496027011653","title":"Developmental signaling and ECM remodeling","description":"This cluster includes a mix of developmental processes (Sertoli cell development, endocrine system development, larval cuticle development), extracellular matrix remodeling (collagen fibril organization), and regulatory signaling/inflammation (negative regulation of angiogenesis, negative regulation of protein kinase activity, non-canonical NF-kappaB signaling, inflammatory response, cellular response to mechanical stimulus) suggesting proteins involved in developmental regulation and tissue remodeling with coordinated signaling and inflammatory cues.","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0060009","count":3}]},{"hash":"579905567276511870","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000398","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0000447","count":4},{"id":"GO:0000480","count":4}]},{"hash":"702872874768003139","title":"Postsynaptic density and synaptic signaling","description":"This cluster is characterized by GO terms for postsynaptic density assembly, gephyrin clustering, and regulation of excitatory/inhibitory postsynaptic potentials, with cytoskeletal organization at the active zone, indicating a cohesive role in synaptic architecture and signaling in neural tissue, while retina development and APP metabolism may reflect related neural processes.","confidence":"High","size":28,"edges":373,"triangles":3149,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":23},{"id":"GO:0008285","count":22},{"id":"GO:0090394","count":22},{"id":"GO:2000463","count":22},{"id":"GO:0097104","count":22}]},{"hash":"271832466988164186","title":"Proviral integration and viral life-cycle proteins","description":"The GO terms cluster around proviral latency establishment, DNA integration and transposition, and multiple viral life-cycle steps (entry into host cells, penetration into the nucleus, and release), indicating a set of proteins involved in viral genome integration and propagation. Some terms also touch on host-symbiont interactions during infection, which aligns with infection-related processes.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0019076","count":3},{"id":"GO:0006313","count":3}]},{"hash":"1915674872918057859","title":"Fatty acid biosynthesis and lipid metabolism","description":"The top terms cluster around fatty acid biosynthesis and metabolism, including long-chain and very long-chain fatty acids, fatty acid import, and related catabolic pathways, plus lipoteichoic acid biosynthesis (a lipid-based component of Gram-positive bacteria). This cohesive set points to lipid metabolism and fatty acid biosynthesis as the core function of the proteins in this cluster.","confidence":"High","size":28,"edges":7,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1902987","count":15},{"id":"GO:0043041","count":13},{"id":"GO:0070395","count":13},{"id":"GO:0006633","count":13},{"id":"GO:0019654","count":12}]},{"hash":"481106984179971107","title":"Mitochondrial respiration and GPCR signaling","description":"The dominant term is electron transport chain with related membrane potential regulation and thermogenesis, pointing to mitochondrial energy production. Complementary terms include adenylate cyclase-activating GPCR signaling and Rho signaling, suggesting concurrent signaling roles that tie energy status to cellular signaling and response to temperature. While some GO terms (e.g., pain, blood pressure) may reflect broader signaling contexts or annotation noise, the core theme centers on mitochondrial respiration coupled with GPCR/cAMP\u2013mediated signaling.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":22},{"id":"GO:0045777","count":22},{"id":"GO:0010579","count":22},{"id":"GO:0035025","count":19},{"id":"GO:0007190","count":19}]},{"hash":"1659131080501217599","title":"Retroviral integration and latency","description":"These GO terms cluster around retroviral processes: RNA-templated DNA biosynthesis (reverse transcription), DNA integration into the host genome, and establishment of integrated proviral latency, along with viral entry into the host nucleus and host apoptosis activation; together they strongly indicate the retroviral replication/latency stage.","confidence":"High","size":28,"edges":308,"triangles":1855,"max_degree":27,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":17},{"id":"GO:0006310","count":16},{"id":"GO:0046718","count":15},{"id":"GO:0075732","count":15},{"id":"GO:0075713","count":15}]},{"hash":"2302089537927893763","title":"DNA transposition and proviral integration","description":"Top GO terms point to DNA recombination, transposition, integration, and RNA-templated DNA synthesis, hallmark activities of transposable elements and retroviruses. The mention of proviral latency and viral entry into the host nucleus reinforces a retroelement/virus-host interaction theme, while DNA integration reflects genome editing by these elements. Overall, the cluster appears to represent DNA mobilization and genome integration functions.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":16},{"id":"GO:0090502","count":13},{"id":"GO:0006313","count":10},{"id":"GO:0075713","count":10},{"id":"GO:0046718","count":10}]},{"hash":"1484452868402520086","title":"Glycan Biosynthesis and Carbohydrate Metabolism","description":"The strongest shared signal is glycan biosynthesis (heparin proteoglycan, chondroitin sulfate) and related carbohydrate metabolism (N-acetylglucosamine), with additional metabolism terms (xenobiotic, flavonoid, thyroid hormone) indicating a broader metabolic role.","confidence":"Medium","size":28,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0000103","count":3},{"id":"GO:0030210","count":3},{"id":"GO:0030206","count":3},{"id":"GO:0009812","count":3}]},{"hash":"437981473236659310","title":"Neural Development and Eye Differentiation","description":"This cluster is dominated by GO terms related to nervous system development and differentiation of ocular tissues, including synapse organization, neuron projection development, myelination, and lens fiber cell differentiation. While there are a few terms pointing to innate immunity, autophagy, and rRNA processing, the core signals align with neural development and eye differentiation, suggesting a cohesive theme around CNS and lens-related maturation. Overall, the label captures the most represented functional area of the cluster.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0050808","count":2},{"id":"GO:0016239","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0042552","count":2}]},{"hash":"694197587736158207","title":"Retroviral and Transposable Element Activity","description":"GO terms in this cluster center on viral entry, proviral latency, and genome integration, together with DNA transposition and retrotransposition. This points to mobile genetic elements, such as retrotransposons and proviral (viral) integration machinery, as the common theme binding the proteins. Some additional terms appear peripheral (ribosome rescue, ubiquitin-dependent catabolic process, TNT degradation) but do not outweigh the core motif of transposable/viral mobility.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":3}]},{"hash":"1598480839435518471","title":"Retroviral life cycle: entry, integration, budding","description":"This cluster's top GO terms cluster around steps in the retroviral life cycle: host cell entry, transport to the nucleus, integration of viral DNA and proviral latency, and budding using the host ESCRT machinery. The presence of DNA transposition and retrotransposition terms also signals homology with retroelements and transposons that share similar mechanisms. Despite one or two outliers (e.g., hematopoietic differentiation), the dominant theme ties to viral genome integration and propagation.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":6},{"id":"GO:0075732","count":6},{"id":"GO:0075713","count":6},{"id":"GO:0015074","count":6},{"id":"GO:0039651","count":6}]},{"hash":"1038943359244448722","title":"Bacterial antibiotic and cofactor biosynthesis","description":"This cluster is dominated by GO terms for biosynthesis of antibiotics and multiple cofactors (biotin, menaquinone, ubiquinone, phylloquinone), suggesting a common theme of bacterial secondary metabolism and small-molecule cofactor production. While a few terms touch on RNA modification and stress responses, the strongest signal is biosynthetic pathways, supporting a label centered on metabolite production.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":24},{"id":"GO:0009102","count":23},{"id":"GO:0009234","count":23},{"id":"GO:0014075","count":22},{"id":"GO:0006370","count":22}]},{"hash":"2052161134487625391","title":"Transcription Regulation and Proviral Latency","description":"These proteins jointly feature DNA-templated transcription and transcriptional regulation (RNA Pol II) and DNA integration/proviral latency, indicating a nuclear regulation theme tied to genome-associated processes. Epigenetic regulation (histone modification) and mRNA splicing further support a gene-expression control cluster, while ROS production and apoptosis terms reflect associated stress responses.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:1900112","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2}]},{"hash":"773040147790167938","title":"Retroviral integration and host immune activation","description":"This cluster centers on GO terms related to viral integration and proviral latency, viral release, and a prominent inflammatory signaling footprint (NF-kappaB activation, IL-1/IL-6/IL-8 responses). The dominant theme is virus\u2013host interaction driving immune pathways, with some auxiliary terms like chitin catabolism being less coherent with the main pattern.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0075713","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0071347","count":3},{"id":"GO:0006915","count":3}]},{"hash":"1256752445439965618","title":"Nervous system development and axonal signaling","description":"Based on GO terms, the cluster is dominated by neurogenesis, CNS/PNS development, nerve impulse transmission, and axon-specific organization (juxtaparanode region, potassium channel clustering), with retina morphogenesis also reflecting neural tissue development. This points to a cohesive group of proteins involved in nervous system development and regulation of axonal excitability, with apoptosis present but not defining the function. ","confidence":"High","size":27,"edges":346,"triangles":2804,"max_degree":26,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0022008","count":20},{"id":"GO:0006915","count":18},{"id":"GO:0019226","count":18},{"id":"GO:0071206","count":18},{"id":"GO:0048671","count":18}]},{"hash":"1318700733221507925","title":"Nuclear mRNA Splicing and Processing","description":"The cluster is strongly enriched for spliceosome-related processes (snRNP and spliceosome assembly, mRNA splicing via spliceosome, spliceosomal complex assembly) and broader nuclear RNA maturation and turnover (import into nucleus, maturation of SSU-rRNA, deadenylation-dependent decapping, termination of RNA Pol II transcription, P-body assembly). This coherence points to a shared role in nuclear RNA processing and maturation, particularly splicing and mRNA turnover, with a few terms that are less central (e.g., hair cycle) likely reflecting pleiotropy rather than cluster identity.","confidence":"High","size":27,"edges":228,"triangles":1016,"max_degree":26,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000387","count":5},{"id":"GO:0006369","count":5},{"id":"GO:0000290","count":4},{"id":"GO:0070317","count":4},{"id":"GO:0051170","count":4}]},{"hash":"1755967075463100763","title":"TLR Signaling and Macrophage Activation","description":"The cluster\u2019s top GO terms center on Toll-like receptor signaling (TLR3/7/9), macrophage activation, and cellular response to lipopolysaccharide, indicating a coherent innate immune activation theme. While a couple of development-related terms appear, the dominant function is immune signaling and macrophage response, justifying a label focused on TLR-driven innate immunity.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":4},{"id":"GO:0034162","count":3},{"id":"GO:0034138","count":3},{"id":"GO:0034154","count":3},{"id":"GO:0042116","count":3}]},{"hash":"2249224377631009366","title":"Actin-driven motility and phagocytosis","description":"The top terms cluster around actin cytoskeleton dynamics (lamellipodium assembly, actin filament polymerization, actin cytoskeleton organization) and processes like phagocytosis, which together point to a role in actin-driven cell movement and membrane remodeling, including protrusion formation and related processes such as dendritic spine morphogenesis and tight junction assembly.","confidence":"High","size":27,"edges":60,"triangles":18,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":3},{"id":"GO:0001878","count":3},{"id":"GO:0006909","count":3},{"id":"GO:0030041","count":3},{"id":"GO:0070830","count":3}]},{"hash":"1680384788954920927","title":"Transcriptional Regulation of Sensory Organ Development","description":"The cluster shows a clear emphasis on transcription-related GO terms (DNA-templated transcription, regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription) alongside development terms for antennal and compound eye photoreceptors, suggesting a theme where transcriptional control drives sensory organ development. Other terms (UV response, Wnt signaling) appear ancillary and do not define the cluster. Therefore, the label captures the dominant trend: transcriptional regulation guiding sensory organ development.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0007469","count":2},{"id":"GO:0045316","count":2}]},{"hash":"1995171988015204355","title":"Spliceosome-regulated mRNA processing","description":"The dominant GO terms point to regulation of mRNA splicing via the spliceosome, regulation of mRNA polyadenylation and tail shortening, and control of mRNA stability under stress. The cluster appears to group proteins involved in post-transcriptional mRNA processing\u2014especially splicing decisions (including alternative splicing) and poly(A) tail regulation\u2014so a concise label is 'Spliceosome-regulated mRNA processing'. Some terms about IRES-dependent viral translation are less central but may reflect broader RNA regulatory roles.","confidence":"High","size":27,"edges":349,"triangles":2876,"max_degree":26,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":20},{"id":"GO:0048026","count":16},{"id":"GO:0006378","count":16},{"id":"GO:0031047","count":16},{"id":"GO:0045292","count":15}]},{"hash":"654674990396773863","title":"Gene expression regulation and chromatin modification in development","description":"This cluster shows enrichment for translation initiation and preinitiation complex formation, transcription, splicing, and histone methylation terms, which point to regulation of gene expression at multiple levels. The presence of gastrulation and multicellular growth terms suggests a developmental context, so the label reflects both molecular regulation and development, despite some broader or unrelated terms present.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002188","count":12},{"id":"GO:0001731","count":12},{"id":"GO:0034729","count":9},{"id":"GO:0050830","count":9},{"id":"GO:0006351","count":9}]},{"hash":"1106626875002075616","title":"Ubiquitin-dependent proteolysis and circadian regulation","description":"This cluster centers on the ubiquitin-proteasome system, with strong signals for ubiquitin-dependent protein catabolic processes, polyubiquitination, and SCF-dependent degradation, coupled with regulation of circadian rhythm. The co-occurrence of stress-response and DNA damage-related terms suggests broader cellular quality control and stress signaling linked to ubiquitin-mediated turnover and clock regulation.","confidence":"High","size":27,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0000209","count":10},{"id":"GO:0042752","count":10},{"id":"GO:0031146","count":10},{"id":"GO:1903378","count":9}]},{"hash":"132655705482286977","title":"Detoxification and Inflammatory Response","description":"This cluster centers on metabolic processing of carbohydrates and xenobiotics (glutathione metabolism, xenobiotic and carbohydrate catabolic processes) and inflammatory signaling (acute-phase response, production of inflammatory mediators, chemokine regulation). The combination suggests proteins linked to detox pathways alongside immune modulation, with some links to protease regulation and cell adhesion that can influence inflammatory cell behavior. Despite no observed direct network edges, the GO pattern points to a coherent detoxification-inflammation theme.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0005975","count":3},{"id":"GO:0006749","count":2},{"id":"GO:0010951","count":2},{"id":"GO:0033629","count":2}]},{"hash":"2118235340837726856","title":"Transcription Regulation & Oxidative Stress Response","description":"This cluster centers on transcription control (negative regulation of RNA polymerase II, DNA binding regulation, DNA-templated transcription) alongside redox and stress response pathways (oxidative stress, redox homeostasis, oxidant detoxification, ER protein folding). The viral process term may be incidental. Overall, the proteins appear linked to transcription regulation coupled with cellular stress management rather than a single enzymatic function.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0043388","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0045454","count":3},{"id":"GO:0034599","count":3}]},{"hash":"505666312519530693","title":"Neural development and DNA replication/repair","description":"This cluster is dominated by GO terms for DNA replication, mitotic cell cycle, DNA-templated transcription, and DNA repair, suggesting a core of proliferative and genome-maintenance activities. At the same time, strong signals for forebrain development, dendrite morphogenesis, and multicellular organism development point to neural differentiation and maturation. The presence of apoptotic and ER-stress\u2013related signaling indicates stress-response ties to these development/differentiation processes, and a portion of innate immune response terms adds a broader cellular-context signal. Overall, the common thread appears to be neural development intertwined with DNA replication/repair and cell-cycle control.","confidence":"Medium","size":27,"edges":62,"triangles":39,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":27},{"id":"GO:0000278","count":23},{"id":"GO:0006351","count":21},{"id":"GO:0006281","count":21},{"id":"GO:0007275","count":20}]},{"hash":"1703884726771742459","title":"Neuronal vesicle trafficking and spine development","description":"The GO terms cluster around intracellular transport (Golgi to plasma membrane, endosome to lysosome, cytoplasm-to-vacuole targeting) and neuronal/synaptic processes (dendritic spine development, GABAergic transmission, brain development), suggesting a cohesive theme of neuronal vesicle transport and synaptic maturation, though a few terms hint at non-neuronal roles.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0032258","count":4},{"id":"GO:0006893","count":4},{"id":"GO:0051932","count":3},{"id":"GO:0007030","count":3},{"id":"GO:0034260","count":3}]},{"hash":"1609019777042325747","title":"Female reproductive development and lipid metabolism","description":"Dominant GO terms include female gonad development, sex differentiation, maternal parturition, prostaglandin biosynthesis, and lipid/P450\u2013mediated pathways (omega-hydroxylase, epoxygenase), triglyceride metabolism, and calcitriol biosynthesis, suggesting a theme of female reproductive development linked to lipid hormone and vitamin D metabolism.","confidence":"High","size":27,"edges":33,"triangles":3,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":25},{"id":"GO:0060736","count":24},{"id":"GO:0033072","count":24},{"id":"GO:0036378","count":24},{"id":"GO:0097267","count":24}]},{"hash":"479815491612250754","title":"Developmental Regulation and Organogenesis","description":"The top GO terms point to developmental processes across multiple tissues (ectoderm formation, cervix and uterine epithelium development) and regulatory signaling (Hippo pathway, miRNA-mediated gene silencing, neural axonogenesis, immune homeostasis). Together they suggest a theme of growth, differentiation, and tissue patterning rather than a single metabolic pathway. The antibiotic biosynthetic process term appears to be an outlier. ","confidence":"Medium","size":27,"edges":314,"triangles":2160,"max_degree":26,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":8},{"id":"GO:0019509","count":7},{"id":"GO:0035331","count":6},{"id":"GO:2000691","count":6},{"id":"GO:2000637","count":6}]},{"hash":"1482425514074343190","title":"Unknown","description":"The listed GO terms span cell adhesion, immune/vascular processes (complement activation, lymphangiogenesis, VEGF/PDGF signaling), basic signaling and ion channel organization, and even neuronal processes (sodium channel clustering). With no edges or triangles and only a few terms shared, there's no clear, cohesive function tying the proteins together, so I label this cluster Unknown.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:1901492","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0045162","count":2}]},{"hash":"924263177925505163","title":"Fatty acid metabolism and lipid transport cluster","description":"Top GO terms cluster around fatty acid metabolism across chain lengths (long-, very long-, medium-chain) and related transport/activation processes, e.g., long-chain fatty acid metabolic process, long-chain fatty acid import into cell, and medium-chain fatty-acyl-CoA metabolic process. A few other catabolic terms are present, but the dominant signal is lipid/ fatty acid metabolism, suggesting a cohesive lipid-processing module.","confidence":"High","size":27,"edges":10,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1902987","count":22},{"id":"GO:0043041","count":21},{"id":"GO:0019654","count":21},{"id":"GO:0090410","count":21},{"id":"GO:0001676","count":21}]},{"hash":"773655538678552301","title":"Coagulation, fibrinolysis, and complement activation","description":"The cluster\u2019s top GO terms center on blood coagulation, fibrinolysis, plasminogen activation, and complement activation via the lectin pathway, with supportive defense responses to Gram-positive bacteria. This points to a theme of extracellular proteolytic cascades linking coagulation and innate immunity. A few terms (lipid A biosynthesis, neuron differentiation, cell budding) are less clearly connected and may reflect annotation noise, but the dominant signal supports coagulation and immune-related proteolysis.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":4},{"id":"GO:0009245","count":4},{"id":"GO:0050830","count":3},{"id":"GO:0071333","count":3},{"id":"GO:0045766","count":3}]},{"hash":"77691143436277674","title":"Neural Sensory Perception and Membrane Potential","description":"This cluster features multiple GO terms tied to sensory modalities (pain, touch, vision) and to membrane potential regulation and cardiac electrophysiology, suggesting a core theme of neural signaling and sensory processing. While there are outliers related to development and host interactions, the dominant signals point to processes governing perception and neuronal excitability.","confidence":"High","size":27,"edges":15,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":4},{"id":"GO:0002024","count":3},{"id":"GO:0071502","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0050976","count":3}]},{"hash":"1792224579050278898","title":"Plant fatty acid metabolism and seed coat development","description":"This cluster repeatedly features GO terms for long-chain and medium-chain fatty acid metabolism and transport, plus related acyl-CoA and carnitine processes, indicating lipid handling in plant cells. The inclusion of seed coat development and phenylpropanoid metabolism suggests a plant-specific linkage to seed biosynthesis, supporting a theme of plant lipid metabolism and seed coat formation.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019654","count":10},{"id":"GO:0090410","count":10},{"id":"GO:0001676","count":10},{"id":"GO:0044539","count":10},{"id":"GO:0019629","count":10}]},{"hash":"1552384769247586322","title":"Bacterial lipid and secondary metabolite biosynthesis","description":"The cluster is dominated by GO terms tied to lipid and lipid-like metabolite production (poly-hydroxybutyrate PHB, fatty acid elongation, mycolic acid, sphinganine metabolism) and also includes antibiotic biosynthetic process, which points to microbial secondary metabolism. Additional terms like retinal and tetrahydrobiopterin biosynthesis, acetoin catabolic process, and transcriptional regulation reflect broader microbial metabolism, but the strongest cohesive theme is lipid biosynthesis and secondary metabolite production in bacteria.","confidence":"Medium","size":27,"edges":12,"triangles":0,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":24},{"id":"GO:0042619","count":23},{"id":"GO:0017000","count":23},{"id":"GO:0006355","count":21},{"id":"GO:0006729","count":21}]},{"hash":"233001535694071104","title":"Diverse Biosynthetic Pathways","description":"This cluster links to a range of disparate biosynthetic processes, including lipopolysaccharide core and O-antigen biosynthesis, sugar metabolism (galactose, GDP-mannose), and various secondary metabolite syntheses (phenylpropanoids, anthocyanins) as well as sporopollenin biosynthesis. The presence of transcription-related GO terms and the absence of edges among proteins suggest a collection of proteins involved in multiple biosynthetic activities rather than a single, cohesive pathway. Therefore, a broad label of Diverse Biosynthetic Pathways is appropriate.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0009244","count":2},{"id":"GO:0006012","count":2},{"id":"GO:0009243","count":2}]},{"hash":"481479118530694749","title":"Arabinogalactan Protein Metabolism","description":"The top GO term is arabinogalactan protein metabolic process, with several related glycosylation and biosynthesis terms (hydroxyproline glycosylation, poly-N-acetyllactosamine, Lewis a) and plant-development annotations like root hair formation and seed coat mucilage, indicating a cluster enriched for hydroxyproline-rich glycoproteins (AGPs) and their biosynthesis/glycosylation pathways.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0010405","count":6},{"id":"GO:0075015","count":6},{"id":"GO:0007299","count":6},{"id":"GO:0042248","count":6},{"id":"GO:0048354","count":6}]},{"hash":"1493594319339822173","title":"TNF/NF-\u03baB inflammatory signaling via ubiquitination","description":"The cluster is dominated by GO terms tying ubiquitination to TNF signaling and NF-\u03baB activation (polyubiquitination, autoubiquitination, I\u03baB phosphorylation, and TNF-mediated pathways). Additional terms point to regulation of apoptosis and TLR signaling, all of which fit a cohesive theme of NF-\u03baB\u2013driven inflammatory responses modulated by ubiquitin processes.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000209","count":6},{"id":"GO:0033209","count":5},{"id":"GO:0007250","count":5},{"id":"GO:0051865","count":5},{"id":"GO:0043066","count":5}]},{"hash":"995527590118721149","title":"Glutamatergic synapse regulation and spine morphogenesis","description":"This cluster centers on glutamatergic synaptic function and spine remodeling, with terms such as positive regulation of glutamatergic transmission, NMDA receptor activity, and receptor localization to synapse, plus dendritic spine morphogenesis and reelin signaling. Lateral motor column neuron migration and adult locomotory behavior further hint at neural circuitry and motor function, aligning with a theme of synaptic regulation and spine development. Some non-specific annotations (defense response to protozoan) may not reflect core function but do not override the dominant neuronal signaling pattern.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010951","count":2},{"id":"GO:0008344","count":2},{"id":"GO:0038026","count":2},{"id":"GO:1900273","count":2},{"id":"GO:0042832","count":2}]},{"hash":"1060296470792221379","title":"Complement-Driven Inflammation and Angiogenesis","description":"The terms cluster around innate immune activation, notably complement pathways (lectin and classical), and inflammatory responses (LPS), along with processes related to leukocyte recruitment and vascular remodeling (angiogenesis, elastin/ECM turnover, SMC-matrix adhesion). This suggests a group of proteins coordinating immune activation with tissue remodeling rather than a single metabolic function.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":9},{"id":"GO:1902947","count":8},{"id":"GO:1903238","count":8},{"id":"GO:2000097","count":8},{"id":"GO:0071333","count":8}]},{"hash":"158705641512919605","title":"DNA repair and replication with genome integration","description":"The top GO terms cluster around DNA metabolism: multiple entries for DNA repair (NER, translesion synthesis), DNA replication and primer removal, DNA gap filling, and DNA integration/transposition, plus cell cycle/division and a proviral latency-related term. Although a couple terms (endothelial proliferation, symbiont-mediated apoptosis) are less central, the dominant theme centers on genome maintenance and genome integration events.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042276","count":2},{"id":"GO:0006297","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0001935","count":2}]},{"hash":"1323081800578612218","title":"Nuclear transport and RNA export","description":"The top GO terms center on import into the nucleus (NLS-bearing protein import, ribosomal protein import), nuclear pore assembly, and mRNA export, indicating a coherent theme of nuclear transport and RNA/protein trafficking. Some peripheral terms (intraciliary transport, chromatid cohesin) are less central to this core, but do not override the dominant signal.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0006607","count":10},{"id":"GO:0043547","count":10},{"id":"GO:0051292","count":9},{"id":"GO:0000060","count":9},{"id":"GO:0060188","count":9}]},{"hash":"467657263834785500","title":"Proteoglycan biosynthesis and sulfation","description":"The cluster is dominated by glycosaminoglycan/proteoglycan-related processes: heparan proteoglycan and chondroitin sulfate biosynthesis, N-acetylglucosamine metabolism, and enzymatic modification of heparan sulfate proteoglycans, plus sulfate assimilation. This suggests a cohesive theme of proteoglycan assembly and sulfation, with related carbohydrate pathways contributing to the shared metabolism. Some other terms like xenobiotic and thyroid hormone metabolism may reflect broader, overlapping enzyme activities but do not override the proteoglycan biosynthesis signal.","confidence":"High","size":26,"edges":68,"triangles":91,"max_degree":15,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000103","count":7},{"id":"GO:0030210","count":7},{"id":"GO:0030206","count":7},{"id":"GO:0009812","count":7},{"id":"GO:0042403","count":7}]},{"hash":"266428415305134630","title":"ER-Golgi Secretory Pathway Proteins","description":"The top terms point to vesicle transport between the ER and Golgi, Golgi retention, and lysosomal targeting, indicating a cluster enriched for components of the secretory/endomembrane trafficking pathway. Immune and cell division terms are present but appear less central, so the core theme is ER-Golgi\u2013related trafficking.","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0051754","count":3},{"id":"GO:0051306","count":3},{"id":"GO:0051301","count":3}]},{"hash":"1692300661818821361","title":"Developmental Signaling and Regulation","description":"The top GO terms suggest a theme of signaling pathways (small GTPase, EGFR signaling) intertwined with regulatory processes (ubiquitination, microtubule localization) and development (heart development, labyrinthine morphogenesis). Immune signaling and receptor clustering (innate immunity, AMPA receptor clustering) add to a broad view of signaling-driven regulation affecting development and cellular organization. Overall, the cluster appears to consolidate signaling and regulatory functions across developmental and immune contexts, rather than a single precise process.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007264","count":3},{"id":"GO:0060670","count":3},{"id":"GO:0007173","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0097113","count":3}]},{"hash":"1806398522338048863","title":"RNA processing and splicing regulation; viral interactions","description":"These proteins are enriched for mRNA processing activities (stabilization, splicing via spliceosome, poly(A) tail regulation) and for viral-related processes (proviral latency, IRES-dependent translation, viral release). The overlap suggests a cluster of RNA processing/splicing factors that also participate in viral gene expression regulation.","confidence":"Medium","size":26,"edges":8,"triangles":2,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048255","count":5},{"id":"GO:0045292","count":4},{"id":"GO:0075713","count":4},{"id":"GO:1900363","count":4},{"id":"GO:0000381","count":4}]},{"hash":"1182267301048404731","title":"Unknown","description":"The GO terms span many distinct processes (cytoskeletal regulation, ER-associated degradation, cytokine signaling, RNA processing, metabolism, and broad developmental roles) with no single unifying theme, so a cohesive function for the cluster cannot be determined from these terms.","confidence":"","size":26,"edges":10,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0034316","count":3},{"id":"GO:0002534","count":2},{"id":"GO:0000348","count":2}]},{"hash":"1920657521573501307","title":"Organ development and cell-cycle regulation","description":"The GO terms point to developmental processes across tissues (lung and kidney development) and a larval chitin-based cuticle development theme, plus cell-cycle control signals (G1 to G0 transition and negative regulation of epithelial proliferation). Several terms are obsolete or metabolism-focused, suggesting annotation noise, but the strongest cohesive theme appears to be development and growth regulation across different tissues. ","confidence":"Medium","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0070689","count":1},{"id":"GO:0046360","count":1},{"id":"GO:0009097","count":1},{"id":"GO:0090502","count":1}]},{"hash":"380672428166450386","title":"DNA transposition and proviral integration","description":"Top terms cluster around genetic element mobility and viral/proviral genome integration, including DNA transposition, DNA integration, retrotransposition, and establishment of proviral latency, with supporting terms about viral entry into host cells. Some ancillary terms (mRNA splicing, RNA primer removal) appear, but the dominant theme is mobile genetic elements and provirus-host genome interactions.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":6},{"id":"GO:0015074","count":5},{"id":"GO:0046718","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0075713","count":3}]},{"hash":"1360692715439173575","title":"Ectodermal and neural development","description":"The terms cluster around embryonic development with strong emphasis on ectoderm-derived tissues and neural patterning: retina development, palatal roof formation, cerebral cortex regionalization, ectoderm formation, and interneuron specification all point to early neural/ectodermal development. Negative regulation of glial differentiation also fits CNS maturation. Ceramide biosynthesis aligns with epidermal/ectodermal biology, while a few terms reference broader embryogenesis or other organs, but the dominant signal is ectodermal and neural development.","confidence":"Medium","size":26,"edges":27,"triangles":5,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":22},{"id":"GO:0060021","count":22},{"id":"GO:0046513","count":22},{"id":"GO:0048557","count":21},{"id":"GO:0035623","count":21}]},{"hash":"655556996384302143","title":"Unknown","description":"The top GO terms are highly heterogeneous, spanning DNA-templated transcription and DNA transposition in the nucleus, post-translational palmitoylation, membrane targeting and Golgi-to-plasma membrane transport, various developmental and signaling processes (chorion development, estrogen receptor signaling, IgG isotype switching), and even obsolete terms. There is no clear, cohesive biological theme tying these functions together, and the interaction graph shows no edges or connectivity. This makes a single interpretable function label unlikely.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0018230","count":1},{"id":"GO:0006612","count":1},{"id":"GO:0043001","count":1},{"id":"GO:0090305","count":1}]},{"hash":"1216928182556660951","title":"Chromatin remodeling and transcription regulation","description":"This cluster is strongly enriched for GO terms related to DNA-templated transcription, RNA polymerase II\u2013mediated transcription and its negative regulation, plus chromatin remodeling. Although a few terms touch on development or immune processes, the dominant themes point to proteins that modulate gene expression through chromatin state and transcriptional control.","confidence":"High","size":26,"edges":168,"triangles":538,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":12},{"id":"GO:0043046","count":6},{"id":"GO:0003289","count":6},{"id":"GO:0003290","count":6},{"id":"GO:0010452","count":6}]},{"hash":"2011627539275933127","title":"Purine nucleotide salvage and catabolism","description":"Top GO terms suggest a strong focus on nucleotide metabolism, with multiple salvage pathways (UMP salvage, purine ribonucleoside salvage, inosine and deoxyguanosine catabolism, urate biosynthesis) dominating the cluster. While phosphorylation and heart development appear, they are less central to the overall pattern, making nucleotide salvage/catabolism the most representative theme.","confidence":"Medium","size":26,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0009636","count":3},{"id":"GO:0006148","count":2},{"id":"GO:0006166","count":2}]},{"hash":"640342551315024664","title":"Vertebrate developmental transcription regulation","description":"The cluster shows enrichment for both positive and negative regulation of transcription by RNA polymerase II, indicating transcriptional control. It also includes several vertebrate developmental processes (roof of mouth/palate development, midbrain development, neural crest cell migration, odontogenesis/dentin formation, atrial septum morphogenesis, ureteric bud branching), suggesting these proteins participate in embryonic development with transcriptional regulation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0060021","count":5},{"id":"GO:0045944","count":5},{"id":"GO:0030901","count":5},{"id":"GO:0043046","count":4}]},{"hash":"888143862079933752","title":"Glucose and sugar transport cluster","description":"This cluster is dominated by GO terms for transmembrane transport of sugars (D-glucose, fructose, lactose-related processes) and accompanying cellular responses to glucose availability (starvation, insulin-stimulated glucose import) as well as osmotic stress. The presence of xenobiotic transport and dehydroascorbic acid transport reinforces a broader transport-centric theme, suggesting these proteins function together as sugar/solute transporters with related stress response roles.","confidence":"High","size":26,"edges":21,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042908","count":26},{"id":"GO:1904659","count":25},{"id":"GO:0042149","count":25},{"id":"GO:0044381","count":25},{"id":"GO:0060731","count":25}]},{"hash":"583566823927389703","title":"Transmembrane Nutrient Transporters","description":"The top GO terms cluster around transport across membranes for small molecules and ions (myo-inositol, pantothenate, biotin, glucose, sodium ions), suggesting a membrane transporter\u2013type function for these proteins. Some non-transport roles (ER stress regulation, T cell signaling, actin assembly) appear as potential noise or multi-function annotations, but the main theme is transmembrane nutrient transport.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015798","count":2},{"id":"GO:0015887","count":2},{"id":"GO:0008292","count":2},{"id":"GO:0071436","count":2},{"id":"GO:0015878","count":2}]},{"hash":"566571040145777793","title":"Neural Sensory Perception and Dopaminergic Signaling","description":"This cluster is dominated by GO terms for sensory perception (pain, vision), visual learning, and dopaminergic synaptic transmission, along with cocaine-related behavioral responses and ERK signaling. These collectively indicate neural signaling and sensory processing pathways as the core theme, despite some pleiotropic terms like heart development appearing among the annotations.","confidence":"Medium","size":26,"edges":154,"triangles":379,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":17},{"id":"GO:0007275","count":15},{"id":"GO:0007601","count":15},{"id":"GO:0071380","count":15},{"id":"GO:0070374","count":15}]},{"hash":"265174997051699688","title":"Multitissue development and neural connectivity","description":"GO terms point to broad developmental roles across tissues, notably neural connectivity (axonogenesis, synapse assembly, excitatory postsynaptic potential, visual perception) and cardiovascular development (angiogenesis, heart development). Although immune-related terms appear, the dominant pattern is development and tissue morphogenesis with an emphasis on neural wiring. The cluster appears to capture proteins involved in diverse developmental processes rather than a single, tightly aligned pathway.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":8},{"id":"GO:0001525","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0014068","count":8},{"id":"GO:0007275","count":8}]},{"hash":"1735820669350673119","title":"Rho/Rac GTPase Signaling and Endocytosis","description":"The top GO terms point to regulation and activity of Rho/Rac GTPases and processes like receptor internalization, implying a shared role in cytoskeletal dynamics and endocytic signaling. Some other terms (ion transport, osmotic stress) appear less connected but may reflect multi-function proteins or incidental annotations; the core theme is GTPase-mediated signaling and endocytosis.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0031623","count":2},{"id":"GO:0048169","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2}]},{"hash":"527242069991879650","title":"RNA Capping and Methylation Machinery","description":"The top terms are dominated by mRNA capping and RNA methylation (7-methylguanosine capping; RNA, tRNA, and rRNA guanine-N7 methylation), indicating proteins involved in RNA maturation and modification. Other terms such as xenobiotic response and organ regeneration appear secondary, suggesting these are incidental associations. Confidence: High","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":15},{"id":"GO:0042493","count":15},{"id":"GO:0036265","count":15},{"id":"GO:0042418","count":13},{"id":"GO:0010243","count":13}]},{"hash":"671570341663206421","title":"Retroviral Integration and Proviral Latency","description":"The cluster is enriched for GO terms such as DNA integration, proviral latency, viral entry into host nucleus, and reverse transcription (RNA-templated DNA biosynthesis), which together point to steps in a retroviral lifecycle that integrates DNA into the host genome and establishes latency.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0046718","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0006310","count":4}]},{"hash":"2020934268291515056","title":"Retroviral DNA integration and latency","description":"The cluster is dominated by GO terms tied to DNA recombination, replication, and integration, plus transposition and RNA-templated DNA biosynthesis, which together point to retroviral-like reverse transcription and genome integration. Additional terms about viral entry into the host nucleus, establishment of proviral latency, and suppression of RNA silencing support a theme of host\u2013virus interactions and proviral maintenance, reinforcing a retroviral integration/latency interpretation.","confidence":"High","size":26,"edges":12,"triangles":0,"max_degree":5,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":13},{"id":"GO:0006260","count":12},{"id":"GO:0046718","count":10},{"id":"GO:0075732","count":10},{"id":"GO:0075713","count":10}]},{"hash":"1625756270696938867","title":"Fatty Acid Metabolism and Related Catabolic Pathways","description":"The cluster is dominated by terms for fatty acid metabolism (medium- and long-chain acyl-CoA processing, fatty acid import) and related carbon-energy pathways (pyruvate fermentation to acetate, malonate and phenylacetate catabolism), with additional linkage to menaquinone biosynthesis. Some terms are obsolete or tangential (e.g., nonribosomal peptide activation), but the core signal points to lipid-centric metabolism and energy-yielding catabolic routes.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0009234","count":7},{"id":"GO:1902987","count":7},{"id":"GO:0036112","count":6},{"id":"GO:0043041","count":5}]},{"hash":"870742723904668106","title":"Unknown","description":"The GO terms span disparate metabolism topics (antibiotic and PHB biosynthesis, retinal metabolism, P450 epoxygenase pathway, phospholipid dephosphorylation, stilbene catabolic process, and detoxification), with no clear shared function or pathway tying all 26 proteins together, and there are no edges connecting them. Therefore, there is no coherent label to assign.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0042619","count":6},{"id":"GO:0017000","count":6},{"id":"GO:0042574","count":5},{"id":"GO:1902987","count":5}]},{"hash":"1271169174276035721","title":"Amino acid biosynthesis and nitrogen metabolism","description":"This cluster centers on biosynthetic pathways for amino acids (lysine and arginine via diaminopimelate and related routes) and related nucleotide metabolism (purine nucleobase) alongside protein degradation and nitrogen scavenging (peptide/proteolysis, allantoin ureide catabolism). The combination suggests a functional module coordinating amino acid synthesis with nitrogen turnover and catabolism rather than a single narrow process.","confidence":"Medium","size":26,"edges":205,"triangles":656,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006144","count":10},{"id":"GO:0019878","count":9},{"id":"GO:0019877","count":8},{"id":"GO:0009089","count":8},{"id":"GO:0055114","count":7}]},{"hash":"1248234792967393893","title":"Synapse development and postsynaptic organization","description":"The top GO terms cluster around synaptic structure and function, including postsynaptic membrane assembly, gephyrin clustering, and regulation of excitatory postsynaptic potentials, pointing to a core role in synapse formation and postsynaptic organization. Related terms such as retina development and amyloid precursor protein metabolism support a neuronal/developmental context, while a few outlier terms (bone development, respiratory nervous regulation) may reflect gene multifunctionality across tissues. ","confidence":"High","size":26,"edges":294,"triangles":1952,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002087","count":22},{"id":"GO:0002076","count":22},{"id":"GO:0060041","count":22},{"id":"GO:0008285","count":18},{"id":"GO:0090394","count":18}]},{"hash":"58677061810086313","title":"Arabinogalactan Protein\u2013Driven Plant Development","description":"GO terms cluster around arabinogalactan protein (AGP) metabolism and glycosylation (AGP metabolic process, poly-N-acetyllactosamine biosynthetic process, hydroxyproline O-linked glycosylation), coupled with plant developmental processes such as root hair cell development, seed coat mucilage biosynthesis, and cell adhesion in developing tissues. This points to a coherent theme of AGP-related glycoprotein modification guiding plant epidermal growth and seed coat formation, despite a few outlier terms. ","confidence":"High","size":26,"edges":106,"triangles":115,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":12},{"id":"GO:0080147","count":10},{"id":"GO:0042248","count":10},{"id":"GO:0048354","count":10},{"id":"GO:0010405","count":10}]},{"hash":"284457981133230468","title":"Nuclear ribosome biogenesis and RNA methylation","description":"The cluster shows strong representation of ribosome biogenesis and nuclear export for ribosomal subunits, along with RNA methylation activities, pointing to a nucleolar/ribosome assembly and RNA processing function; a couple of peripheral biosynthetic terms may be less central to the core function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0000056","count":2},{"id":"GO:0032259","count":2},{"id":"GO:0006656","count":2},{"id":"GO:0036265","count":2}]},{"hash":"1985917816914984716","title":"Rho GTPase signaling and actin remodeling","description":"This cluster is dominated by GO terms related to small GTPase signaling, especially Rho family, and lamellipodium assembly, indicating a common theme of cytoskeletal regulation and cell migration. Additional terms point to broader signaling pathways (thrombin receptor, IGF receptor) and membrane-associated processes (sterol biosynthesis), suggesting membrane dynamics support these signaling and remodeling activities. Overall, the shared function appears to be Rho GTPase\u2013driven cytoskeletal dynamics with associated signaling. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016126","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0030032","count":2},{"id":"GO:0007264","count":2},{"id":"GO:0010765","count":2}]},{"hash":"1748919850021129829","title":"Neuronal development and signaling","description":"This cluster is dominated by GO terms for neuronal development and morphogenesis, including dendritic spine morphogenesis, neuron development, and cell migration, alongside signaling and trafficking processes such as ephrin receptor signaling, JUN phosphorylation, and caveolin-mediated endocytosis, which together point to neural development and synaptic remodeling. Telomere maintenance and apoptotic processes appear as less central or secondary associations. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060997","count":5},{"id":"GO:1904355","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0032212","count":4},{"id":"GO:0006915","count":4}]},{"hash":"127809750840094280","title":"RNA Methylation and Capping","description":"The top GO terms are dominated by RNA modification processes\u20147-methylguanosine mRNA capping and RNA (guanine-N7)-methylation\u2014with supporting terms for tRNA wobble modification and arginine methylation, indicating a core theme around RNA modification/processing. Other terms (stress or metabolic responses) appear peripheral but do not override the RNA-focused signal. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":22},{"id":"GO:0036265","count":22},{"id":"GO:0009877","count":20},{"id":"GO:0046690","count":20},{"id":"GO:0002098","count":20}]},{"hash":"1717664305556015470","title":"Embryonic organogenesis and tissue morphogenesis","description":"Enriched terms cluster around embryonic development and organ/tissue formation, spanning cartilage and biomineral tissues, endocrine and pancreatic development, heart-related EMT, left-right patterning, and placental differentiation. The common thread is developmental morphogenesis and lineage specification, indicating a cohesive embryogenesis-focused cluster.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031214","count":6},{"id":"GO:0030194","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0000122","count":5},{"id":"GO:0035270","count":5}]},{"hash":"2104808061788918295","title":"Fatty acid and sphingolipid biosynthesis","description":"The top GO terms show strong enrichment for lipid biosynthetic processes, including unsaturated fatty acid biosynthesis, fatty acid elongation (mono- and polyunsaturated), long-chain fatty-acyl-CoA biosynthetic, and sphingolipid biosynthesis, pointing to fatty acid and sphingolipid metabolism as the cluster's core function. Additional terms about post-Golgi vesicle transport and endosome-to-vacuole trafficking suggest associated membrane trafficking required for lipid-modifying enzymes and lipid-containing organelles. Taken together, the cluster likely represents proteins involved in lipid biosynthesis and related trafficking.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006636","count":3},{"id":"GO:0006892","count":3},{"id":"GO:0042810","count":3},{"id":"GO:0007619","count":3},{"id":"GO:0034625","count":3}]},{"hash":"2115361743255008698","title":"Viral integration and transposition machinery","description":"This cluster is enriched for GO terms related to DNA transposition, DNA integration, and DNA recombination, as well as processes describing proviral latency and viral entry into the host nucleus. The presence of these terms suggests proteins such as transposases and integrases that mobilize genetic elements and establish provirus, even in symbiont-host interactions. Therefore a concise label capturing both transposition and proviral integration best represents the cluster.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":6},{"id":"GO:0090305","count":5},{"id":"GO:0015074","count":3},{"id":"GO:0046718","count":2},{"id":"GO:0090502","count":2}]},{"hash":"357145925508262955","title":"Wnt and Stress-Response Signaling with Ubiquitination","description":"This cluster centers on signaling and stress-immune processes: Wnt signaling is the top pathway, with related regulation of ephrin signaling and NOD-like receptor signaling; stress responses include heat and cold; ubiquitination suggests post-translational control of signaling components; includes myeloid apoptosis and pain perception. Taken together, these terms point to a module where developmental and immune signaling intersect with ubiquitin-mediated regulation under stress.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":3},{"id":"GO:0045736","count":3},{"id":"GO:0009409","count":2},{"id":"GO:0009408","count":2},{"id":"GO:0016567","count":2}]},{"hash":"531698445440194090","title":"Innate immune signaling and cellular stress responses","description":"Reasoning: The top terms center on NOD1/NOD2 signaling and NF-kappaB regulation, with protein ubiquitination suggesting post-translational control of signaling. Additional terms reflect heat/cold stress responses and myeloid cell\u2013related apoptosis, indicating a cluster of innate immune signaling components influenced by cellular stress and ubiquitination.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0032088","count":5},{"id":"GO:0070431","count":4},{"id":"GO:0009409","count":3},{"id":"GO:0009408","count":3},{"id":"GO:0016567","count":3}]},{"hash":"1703887607336881208","title":"Unknown","description":"GO terms span kinase autophosphorylation, DNA transposition, Rho signaling, host cell entry, heart development, multiple transports, and neurotransmitter biosynthesis; the mix is diverse with no clear shared pathway or interactions, so no cohesive label can be assigned.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046777","count":4},{"id":"GO:0006313","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0046718","count":4},{"id":"GO:0007507","count":4}]},{"hash":"2190172273799494870","title":"Ubiquitin-Dependent Protein Degradation and Histone Ubiquitination","description":"The top GO terms show a strong emphasis on ubiquitin-mediated processes: ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-dependent protein catabolic process, and autoubiquitination, including specific linkages (K6, K63, K48). Histone catabolic process and DNA-templated transcription further connect ubiquitin signaling to chromatin and transcription regulation. A related term on TNF signaling suggests broader ubiquitin-related signaling roles. Overall, these terms point to a cluster centered on ubiquitination-driven protein turnover and chromatin modification.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0036205","count":7},{"id":"GO:0051865","count":6},{"id":"GO:1903265","count":6},{"id":"GO:0085020","count":6}]},{"hash":"2158213985895383364","title":"Skeletal muscle differentiation and sarcomere organization","description":"The strongest signals in this cluster are skeletal muscle cell differentiation and sarcomere organization, pointing to a role in muscle development and assembly of the contractile apparatus. Supporting terms like actin cytoskeleton reorganization and regulation of Rho signaling reinforce a theme of cytoskeletal remodeling crucial for muscle fibers. Ubiquitin-dependent protein catabolic processes, including protein autoubiquitination, suggest concomitant protein turnover during differentiation and sarcomere remodeling. While there are some broader terms (e.g., cell division, transcription regulation) that are less specific, the core connectivity centers on muscle differentiation and sarcomere maintenance.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0035914","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0000278","count":2}]},{"hash":"2256099374980615145","title":"Embryonic development and tissue morphogenesis","description":"The cluster\u2019s top GO terms cluster around developmental differentiation and tissue morphogenesis\u2014embryonic placenta development, left-right pattern formation, cartilage morphogenesis, pancreatic cell development, EMT in heart formation, and trophoblast differentiation\u2014suggesting a shared theme of developmental processes. A couple of terms (antibiotic biosynthetic process, DNA transposition) appear unrelated, indicating some noise but not redefining the main signal.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":3},{"id":"GO:0006313","count":3},{"id":"GO:0035270","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0003323","count":2}]},{"hash":"1321379995610257092","title":"Nuclear import, chromatin remodeling, and cell cycle control","description":"The cluster\u2019s top GO terms center on nuclear processes: import of NLS-bearing proteins into the nucleus, transcription-initiation\u2013coupled chromatin remodeling, and regulation of the cell cycle. Additional signals include GTPase activity modulation and cell proliferation regulation, with some peripheral terms related to cell adhesion and neural development. Overall, the dominant theme is nuclear transport and chromatin dynamics governing cell cycle progression, supporting this label.","confidence":"Medium","size":25,"edges":200,"triangles":883,"max_degree":24,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0015991","count":10},{"id":"GO:0006607","count":8},{"id":"GO:0043547","count":8},{"id":"GO:0007050","count":8},{"id":"GO:0048096","count":7}]},{"hash":"927776950862523970","title":"Lens protein homeostasis under light/oxidative stress","description":"This cluster centers on protein stability and quality control under light- and heat-induced stress (high light, UV-A, heat, hydrogen peroxide), with a specific tie to lens biology (lens fiber cell morphogenesis) and protein handling processes (amyloid prevention, oligomerization regulation). The combination suggests a theme of maintaining protein integrity in lens cells under oxidative and light stress.","confidence":"High","size":25,"edges":299,"triangles":2277,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0050821","count":8},{"id":"GO:1905907","count":8},{"id":"GO:0009644","count":8},{"id":"GO:0009408","count":8},{"id":"GO:0070309","count":8}]},{"hash":"199391310358125225","title":"Lens photostress response and protein stabilization","description":"The top GO terms cluster around light and oxidative stress responses (response to heat; response to high light intensity; response to UV-A; response to hydrogen peroxide) alongside lens-related development (lens fiber cell morphogenesis) and protein homeostasis (protein stabilization; negative regulation of protein homooligomerization; negative regulation of amyloid fibril formation). This suggests a coherent theme of protecting lens cells from photooxidative damage and maintaining protein stability, a hallmark of lens biology and chaperone-like activity. Some terms like estradiol response or muscle contraction are broader, but they do not override the dominant lens-light-stress signal.","confidence":"High","size":25,"edges":66,"triangles":84,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":9},{"id":"GO:0050821","count":6},{"id":"GO:1905907","count":6},{"id":"GO:0009644","count":6},{"id":"GO:0070309","count":6}]},{"hash":"58793690506360084","title":"DNA-Templated Transcription Regulation","description":"The top GO terms are dominated by DNA-templated transcription and its regulation, indicating a transcriptional regulatory theme for this cluster. While there are some metabolic terms present (e.g., various catabolic and fatty acid processes) and several entries are obsolete, the strongest and most coherent signal centers on transcriptional control. Therefore, the label reflects the likely core function, with moderate confidence due to mixed signals and lack of network connectivity.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1902987","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0040008","count":3},{"id":"GO:0055114","count":3}]},{"hash":"1302579157337638475","title":"Retroviral entry and proviral integration","description":"Based on the GO terms, the cluster centers on viral entry into host cells and nuclei, reverse transcription (RNA-templated DNA synthesis), DNA integration and recombination, and establishment of proviral latency. The combination of entry, reverse transcription, genome integration, and latency strongly points to a retroviral life cycle rather than general host cell functions. ","confidence":"High","size":25,"edges":97,"triangles":114,"max_degree":18,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0046718","count":6},{"id":"GO:0090502","count":6},{"id":"GO:0075732","count":6},{"id":"GO:0043137","count":6}]},{"hash":"632877286461456473","title":"DNA Damage and Antibiotic Stress Response","description":"The cluster\u2019s top terms center on DNA replication and the SOS response, with several entries for response to antibiotic and toxic substances, indicating a core theme of DNA-damage sensing/repair and antibiotic-stress adaptation; other terms suggest metabolic remodeling, but the stress-response signal is dominant.","confidence":"Medium","size":25,"edges":16,"triangles":1,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0006695","count":4},{"id":"GO:0046677","count":4},{"id":"GO:0009432","count":4},{"id":"GO:1903351","count":3}]},{"hash":"2050714352122921472","title":"Unknown","description":"The top GO terms span very disparate areas, including intracellular trafficking (ER to Golgi transport), DNA replication, lipid biosynthesis, immune homeostasis, organ development, synaptic signaling, transcriptional regulation, and responses to drugs, with no clear overarching theme connecting all proteins. This lack of a cohesive biological function suggests the cluster does not map to a single, well-defined process.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006888","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0009245","count":6},{"id":"GO:0043029","count":6},{"id":"GO:0030324","count":6}]},{"hash":"760118257140896713","title":"Developmental Signaling and Growth Regulation","description":"The top terms point to major signaling pathways (Wnt, Hippo) that regulate growth, apoptosis, and differentiation (keratinocytes, dendrite morphogenesis) as well as cell cycle control and exocytosis. This pattern suggests a theme of signaling-driven cell fate and tissue growth regulation rather than a single, specific function, so the label Developmental Signaling and Growth Regulation is representative.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":18},{"id":"GO:0006915","count":17},{"id":"GO:0060044","count":17},{"id":"GO:0035329","count":17},{"id":"GO:0030216","count":17}]},{"hash":"2247241862576835274","title":"DNA replication and RNA processing","description":"This cluster includes GO terms for DNA replication steps (unwinding, primer synthesis, topological changes) and SOS response, plus RNA processing/surveillance (nonsense-mediated decay, RNA-protein cross-linking) and ribosome assembly, with transcription regulation by RNA Pol II. Together, these suggest a module integrating genome maintenance with RNA processing and gene expression.","confidence":"High","size":25,"edges":66,"triangles":220,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009432","count":15},{"id":"GO:0006268","count":15},{"id":"GO:0006269","count":15},{"id":"GO:0000184","count":14},{"id":"GO:0045944","count":14}]},{"hash":"1584709576732794788","title":"Developmental growth and mitosis","description":"This cluster is enriched for both developmental processes (larval cuticle development, multicellular organism growth) and core cell-cycle/mitotic functions (mitotic cell cycle, cell division, mitotic spindle assembly) as well as related machinery (translational elongation, COPII vesicle budding, protein heterooligomerization). The combination suggests a theme around growth coupled with cell division and basic biosynthetic/trafficking processes, rather than a highly specialized function. Confidence: Medium","confidence":"","size":25,"edges":126,"triangles":250,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008363","count":7},{"id":"GO:0000278","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0006414","count":4},{"id":"GO:0051291","count":3}]},{"hash":"2025889345357314402","title":"Unknown","description":"The top GO terms cover very divergent processes: DNA integration and proviral latency, symbiont-induced host apoptosis, RNA splicing, vesicle transport, and various development and stress-response processes. There is no clear, single function or pathway linking these terms, suggesting a heterogeneous mix rather than a cohesive cluster function.","confidence":"","size":25,"edges":24,"triangles":0,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0000398","count":3},{"id":"GO:0043001","count":2}]},{"hash":"1877848694428313440","title":"Gene expression and mitochondrial energy metabolism","description":"This cluster is driven by terms for translation, transcription, and rRNA maturation, indicating core gene expression and ribosome biogenesis, plus DNA repair suggesting genome maintenance. The presence of mitochondrial electron transport implies energy production. Some terms (e.g., photosynthesis, broad transport, apoptotic terms) may be annotations from diverse contexts, but the central theme ties to essential cellular information flow and mitochondrial respiration.","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0055114","count":3},{"id":"GO:0006123","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006281","count":2}]},{"hash":"59737093679303428","title":"Mitotic progression and protein quality control","description":"This cluster centers on mitotic regulation (APC/C-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition) and proteostasis (response to unfolded protein), suggesting proteins involved in cell-cycle control and protein folding/quality control. The combination of cell-cycle and stress-response terms supports a coherent theme despite some noise in obsolete terms.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006626","count":2},{"id":"GO:0031145","count":1},{"id":"GO:1901215","count":1},{"id":"GO:0035955","count":1},{"id":"GO:0043278","count":1}]},{"hash":"498259840822413264","title":"Stress-responsive RNA processing and translation regulation","description":"This cluster centers on post-transcriptional control of gene expression: stress-induced regulation of mRNA stability, splicing, polyadenylation, and translation initiation/reinitiation, plus ncRNA-mediated silencing. The GO terms converge on RNA processing and translation control under stress, supporting a cohesive RNA metabolism module.","confidence":"High","size":25,"edges":10,"triangles":1,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":17},{"id":"GO:1901407","count":16},{"id":"GO:0045292","count":15},{"id":"GO:0006378","count":15},{"id":"GO:0002188","count":15}]},{"hash":"466442931297552456","title":"Chromatin regulation and transcription control","description":"The GO terms are dominated by DNA transposition and chromatin organization, with related transcription regulation and protein modification processes (ubiquitination, phosphorylation). This points to a cluster centered on chromatin dynamics and control of gene expression, rather than a single metabolic or structural pathway; a few outlier terms (collagen catabolic process, endothelial proliferation) appear less connected, but the core theme remains chromatin-centric regulation. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":4},{"id":"GO:0034724","count":2},{"id":"GO:0034396","count":2},{"id":"GO:0035551","count":2},{"id":"GO:0030574","count":2}]},{"hash":"1128462534198254755","title":"Translation and Metabolic Biosynthesis Cluster","description":"This cluster shows a strong signal for translation (protein synthesis) with five proteins, plus multiple biosynthetic processes (biotin, menaquinone, antibiotic, poly-hydroxybutyrate, sterol), suggesting involvement in both ribosome-related function and diverse metabolite biosynthesis typical of microbial systems. The additional terms for xenobiotic response and GTPase regulation hint at broader cellular signaling, but the dominant theme appears to be translation alongside diverse biosynthetic capabilities.","confidence":"Medium","size":25,"edges":219,"triangles":898,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0055114","count":4},{"id":"GO:0009102","count":2},{"id":"GO:0016126","count":2},{"id":"GO:0017000","count":2}]},{"hash":"1193799418161990800","title":"Developmental transcriptional regulation and hematopoiesis","description":"This cluster centers on transcriptional control (DNA-templated transcription, RNA Pol II regulation, and miRNA transcription) with differentiation signals toward hematopoietic lineages (granulocyte and erythrocyte differentiation) and developmental contexts (midbrain development, gastrulation). The common theme is regulation of gene expression during development and lineage specification.","confidence":"Medium","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030851","count":7},{"id":"GO:0045648","count":7},{"id":"GO:0007568","count":7},{"id":"GO:0000122","count":7},{"id":"GO:0030901","count":6}]},{"hash":"729516104264121212","title":"Drosophila Developmental Gene Regulation and RNA Splicing","description":"The terms point to developmental processes in Drosophila (antennal development, head segmentation, eye photoreceptor development, tracheal system) together with regulation of transcription and RNA splicing, suggesting a cluster focused on developmental gene expression and RNA processing (with some apoptosis-related terms as broader context).","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007469","count":2},{"id":"GO:0045316","count":2},{"id":"GO:0034247","count":2}]},{"hash":"805434357046984955","title":"Chloroplast RNA processing and isoprenoid biosynthesis","description":"The cluster combines organellar RNA processing (chloroplast rRNA processing, mitochondrial RNA processing, RNA splicing) and transcription regulation with plastid-associated metabolic pathways (carotenoid, farnesyl diphosphate/ergosterol biosynthesis) and red/far-red light phototransduction, suggesting a cohesive role in chloroplast gene expression linked to isoprenoid metabolism and light signaling.","confidence":"Medium","size":25,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008380","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0009585","count":2},{"id":"GO:0006457","count":2},{"id":"GO:0016120","count":1}]},{"hash":"2301836202040524228","title":"Coagulation and Complement Activation","description":"The proteins are enriched for complement activation (lectin and classical pathways) and multiple coagulation-related terms (positive regulation of blood coagulation, fibrinolysis, plasminogen activation, Factor XII activation), plus ECM-related processes like collagen catabolic process and biomineral tissue development. This combination points to a cohesive theme around coagulation and complement pathways with concurrent extracellular matrix remodeling during tissue repair, rather than a single specific enzyme activity.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":11},{"id":"GO:0030194","count":11},{"id":"GO:0030574","count":10},{"id":"GO:0031214","count":10},{"id":"GO:0000122","count":9}]},{"hash":"42670450270273075","title":"Retroviral DNA entry, integration, and latency","description":"This cluster is dominated by terms tied to retroviral biology: viral entry into the host cell/nucleus, DNA recombination and integration, RNA-templated DNA synthesis, and establishment of proviral latency, with supporting signals of host RNAi interference and apoptosis modulation. Together these points align with the retroviral life cycle and proviral maintenance within the host genome.","confidence":"High","size":25,"edges":299,"triangles":2277,"max_degree":24,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":22},{"id":"GO:0006260","count":17},{"id":"GO:0046718","count":16},{"id":"GO:0075732","count":16},{"id":"GO:0075713","count":16}]},{"hash":"1677655448960039334","title":"Synaptic and Immune Signaling Regulation","description":"The top GO terms span neural signaling (excitatory postsynaptic potential; regulation of axon extension/axonogenesis) and immune signaling (T cell receptor signaling; mast cell degranulation; JNK cascade; focal adhesion regulation; PI3K activity; beta selection), suggesting a cluster of proteins that broadly regulate signal transduction in both neurons and immune cells. The terms point to regulatory roles in synaptic activity and immune receptor pathways, with additional links to cell adhesion and phosphorylation events, supporting a unifying theme of signaling regulation across systems.","confidence":"Medium","size":25,"edges":4,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":19},{"id":"GO:0045773","count":19},{"id":"GO:0043552","count":19},{"id":"GO:0043304","count":19},{"id":"GO:0043366","count":19}]},{"hash":"1687791492315632162","title":"Unknown","description":"The top GO terms cover a mix of bacterial antigen biosynthesis, ROS regulation, chromatin-related processes, DNA replication, membrane trafficking, mitochondrial function, and cytokine signaling, with little coherent overlap. This dispersion suggests no single clear biological theme for the cluster, so a generic Unknown label is most appropriate.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009246","count":3},{"id":"GO:2000379","count":2},{"id":"GO:0000183","count":2},{"id":"GO:0051572","count":2},{"id":"GO:0071897","count":1}]},{"hash":"148129484863293535","title":"Endothelial barrier and coagulation regulation","description":"The top GO terms are dominated by endothelial-related processes (establishment of endothelial barrier, leukocyte tethering/rolling), along with blood coagulation and smooth muscle cell\u2013matrix adhesion, pointing to vascular integrity, immune cell trafficking, and hemostasis as the core theme. Additional terms (biomineral tissue development, digestion) are present but less central. Overall, the cluster appears to capture vascular and inflammatory regulatory functions.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":9},{"id":"GO:1903142","count":8},{"id":"GO:0031214","count":8},{"id":"GO:0007586","count":8},{"id":"GO:0030194","count":8}]},{"hash":"1257419975231323996","title":"Receptor signaling and cytoskeleton dynamics","description":"The prominent terms point to cell adhesion/spreading and actin cytoskeleton remodeling, together with signals from growth factor and immune receptors (EGF/IGF, TCR) and receptor internalization\u2014a coherent theme of surface signaling linked to cytoskeletal changes. A small subset of terms (DNA transposition/integration, labyrinthine layer development) seem more peripheral, suggesting some annotation noise.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034446","count":3},{"id":"GO:2000251","count":3},{"id":"GO:0061099","count":3},{"id":"GO:0006313","count":2},{"id":"GO:0015074","count":2}]},{"hash":"299797777027557165","title":"Proteostasis and stress response","description":"The terms cluster around protein quality control and cellular stress responses, including ubiquitin-dependent degradation (ERAD), autophagy-related processes, oxidative stress response, and stress signaling (cadmium). Peroxisome matrix import and microtubule dynamics fit within broader proteostasis and organelle maintenance themes, suggesting the proteins collectively help maintain protein/homeostasis under stress rather than a single, narrow pathway.","confidence":"Medium","size":24,"edges":10,"triangles":0,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0016558","count":5},{"id":"GO:0031117","count":5},{"id":"GO:0030420","count":4}]},{"hash":"1979562299030108641","title":"Nuclear transport and mitotic regulation cluster","description":"Most of the top GO terms converge on cell cycle control and nuclear transport: DNA-templated transcription, mitotic cell cycle, negative regulation of protein export from nucleus, and protein localization to kinetochore. Additional terms point to intracellular targeting and membrane association (protein targeting to membrane, localization to kinetochore, tight junction regulation), and the signaling responses to prostaglandin E and ethanol reflect broader cellular response context. Together, these terms suggest a cohesive theme around coordinating gene expression with chromosome segregation and protein localization during cell division.","confidence":"Medium","size":24,"edges":54,"triangles":122,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071380","count":13},{"id":"GO:0071361","count":13},{"id":"GO:0006351","count":12},{"id":"GO:0000278","count":12},{"id":"GO:0046826","count":12}]},{"hash":"1825365076673734579","title":"Central metabolism and lipid biosynthesis","description":"The cluster is enriched for several biosynthetic and metabolic processes, notably NAD+ and polyamine biosynthesis, oxaloacetate metabolism, lipoprotein biosynthesis, and regulation of cholesterol biosynthesis, which points to lipid-related metabolism as a core theme. The ER-to-Golgi vesicle transport term supports lipid/protein trafficking needed for lipoprotein assembly, while mitochondrial inheritance aligns with energy-related organization. Together, these terms suggest a cohesive group centered on metabolic biosynthesis with a focus on lipids and energy metabolism, with some ancillary trafficking and stress-related terms accompanying them.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000001","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0009435","count":2},{"id":"GO:0006596","count":2},{"id":"GO:0006107","count":2}]},{"hash":"830544289727204292","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":14,"triangles":3,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0006370","count":2},{"id":"GO:0006362","count":2},{"id":"GO:1904669","count":2},{"id":"GO:0006295","count":2}]},{"hash":"1201510555922723283","title":"Unknown","description":"The top GO terms are highly diverse, spanning vascular, reproductive, lipid/hormone biosynthesis, and even transposon activity, with no single coherent function linking the cluster. Therefore there is no clear shared theme to name the cluster beyond Unknown.","confidence":"","size":24,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":5},{"id":"GO:0006313","count":5},{"id":"GO:0060736","count":1},{"id":"GO:0033072","count":1},{"id":"GO:0036378","count":1}]},{"hash":"1206226717631003405","title":"Unknown","description":"The top GO terms span nuclear processes (chromatin remodeling, mitotic chromosome condensation, transcription regulation, exit from mitosis) and vesicle trafficking (multivesicular body assembly, endosome transport, vacuolar transport), with an additional neural development term and ATP export. There isn\u2019t a single cohesive function that clearly ties all proteins together, making it inappropriate to assign a specific, concise label. ","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043044","count":3},{"id":"GO:0007076","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0000122","count":2},{"id":"GO:1904669","count":1}]},{"hash":"1583150976185983808","title":"Proviral integration and retroelement activity","description":"The top GO terms strongly cluster around DNA transposition, DNA integration, retrotransposition, and establishment of integrated proviral latency, which point to retroelements and proviruses integrating into the host genome. Additional terms about viral entry and symbiont interactions fit with host\u2013pathogen/parasite dynamics that accompany proviral cycles, reinforcing a cohesive theme of retroelement/proviral activity in the genome.","confidence":"High","size":24,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":16},{"id":"GO:0046718","count":15},{"id":"GO:0075732","count":15},{"id":"GO:0075713","count":15},{"id":"GO:0015074","count":15}]},{"hash":"757058778716357957","title":"Embryonic Organ Morphogenesis","description":"Proteins in this cluster are enriched for embryonic development and organ morphogenesis terms, including digestive tract morphogenesis, lacrimal gland development, neural tube patterning, and nephron tubule formation, along with stem cell proliferation regulation and vascular morphogenesis. Translation and transcription terms appear but are more general; the shared theme appears to be embryonic tissue formation and organogenesis.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0006351","count":3},{"id":"GO:0048557","count":2},{"id":"GO:0072091","count":2},{"id":"GO:0032808","count":2}]},{"hash":"1120084027051576875","title":"Mitochondrial translation and cardiac function","description":"The cluster is dominated by GO terms for translation and mitochondrial translation, with additional emphasis on mitochondrial rRNA maturation and protein folding, plus a couple of heart-specific terms (cardiac ventricle development and regulation of cardiac conduction). This points to a core role of mitochondrial protein synthesis machinery, with possible relevance to cardiac physiology. ","confidence":"Medium","size":24,"edges":270,"triangles":1897,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0032543","count":4},{"id":"GO:0006915","count":2},{"id":"GO:0003231","count":2},{"id":"GO:1903779","count":2}]},{"hash":"171179146435898952","title":"APC/C-Mediated Mitosis and Ubiquitination","description":"Top GO terms point to metaphase/anaphase transition, cell division, and K11-linked ubiquitination, suggesting APC/C-driven regulation of mitosis via targeted protein degradation. While there is also an unfolded protein response signal, the core pattern reflects cell-cycle control through ubiquitin-mediated proteolysis during division.","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0007091","count":5},{"id":"GO:0070979","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0055114","count":5},{"id":"GO:1902987","count":5}]},{"hash":"2233348203346321169","title":"Auditory Synapse Plasticity and Vocalization","description":"The top GO terms center on synapse development, localization, and structural modulation (dendritic spine morphogenesis, protein localization to synapse, receptor clustering, positive regulation of synapse structural plasticity, long-term synaptic depression), along with sound-related and social/vocal behaviors (sensory perception of sound, vocalization behavior, social behavior) and excitatory signaling (positive regulation of excitatory postsynaptic potential). This points to a cluster of proteins coordinating synapse formation and plasticity in neural circuits governing auditory processing and related behaviors, justifying a name that emphasizes synaptic plasticity in auditory-vocal behavior.","confidence":"High","size":24,"edges":39,"triangles":16,"max_degree":22,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060997","count":9},{"id":"GO:0007605","count":9},{"id":"GO:0035418","count":8},{"id":"GO:0051835","count":8},{"id":"GO:0060292","count":8}]},{"hash":"705282862506698786","title":"RNA Capping and Methylation Machinery","description":"The top terms are dominated by RNA processing: mRNA 7-methylguanosine capping and RNA guanine-N7 methylation, plus tRNA wobble uridine modification and peptidyl-arginine/arginine methylation. This points to a cluster of proteins involved in RNA cap formation and post-transcriptional RNA modification, with other terms likely representing noise or secondary roles.","confidence":"High","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":21},{"id":"GO:0036265","count":21},{"id":"GO:0042418","count":20},{"id":"GO:0010243","count":20},{"id":"GO:0031100","count":20}]},{"hash":"583602617077388513","title":"Mitochondrial translation and tRNA charging","description":"The cluster is strongly enriched for translation-related GO terms (translation; regulation of translational fidelity) plus mitochondrially specific tRNA aminoacylation (glycyl-tRNA and threonyl-tRNA charging), pointing to a coherent theme of mitochondrial protein synthesis. Some other terms (menaquinone biosynthesis, embryonic development) appear less connected and may reflect annotation noise or broader associations.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006450","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0009234","count":2},{"id":"GO:0009086","count":2},{"id":"GO:0055114","count":2}]},{"hash":"794457633692053221","title":"Synaptic amino acid transport and NMDA signaling","description":"This cluster is characterized by multiple amino-acid transport activities across membranes (including methionine, lysine, arginine, ornithine, D-alanine, D-serine) together with signals related to synapse assembly and NMDA receptor modulation (D-serine/D-alanine), plus arginine-driven nitric oxide production and GPCR-associated signaling. The combination points to a cohesive role in neuronal synaptic function mediated by amino acid transport and related signaling pathways.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":6},{"id":"GO:0044690","count":6},{"id":"GO:0097639","count":6},{"id":"GO:0002537","count":6},{"id":"GO:0042941","count":6}]},{"hash":"1770079958168114174","title":"Neural signaling and synaptic plasticity","description":"The top GO terms are dominated by neural-related functions: social behavior, memory (short/medium/long-term), long-term synaptic depression, sensory perception of touch, and rhythmic excitation. These collectively point to proteins involved in neuronal signaling and synaptic regulation, rather than generic metabolic processes. Therefore, the cluster appears to reflect neural signaling and synaptic plasticity.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":4},{"id":"GO:0072375","count":4},{"id":"GO:0060292","count":4},{"id":"GO:0010226","count":3},{"id":"GO:0060992","count":3}]},{"hash":"827119606206566865","title":"Diverse lipid and small-molecule biosynthesis","description":"The top GO terms cluster around biosynthetic and metabolic processes for lipids and related compounds (poly-hydroxybutyrate, fatty acid elongation, mycolic acid, sphinganine, retinal, estrogen), suggesting a group of proteins involved in lipid and small-molecule biosynthesis across contexts. Some terms (transcription regulation, acetoin catabolism) are more peripheral or reflect multifunctionality, but the dominant theme is biosynthesis/metabolism of lipid- and steroid-like molecules. ","confidence":"Medium","size":24,"edges":71,"triangles":34,"max_degree":11,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":23},{"id":"GO:0055114","count":23},{"id":"GO:0006355","count":22},{"id":"GO:0006729","count":22},{"id":"GO:0045150","count":22}]},{"hash":"585055769774626134","title":"Lipid, steroid, and retinoid biosynthesis","description":"The cluster is strongly enriched for biosynthetic processes across lipids and lipid-derived metabolites: fatty acid elongation, mycolic acid biosynthesis, sphinganine metabolism (lipids), retinal metabolism, and estrogen biosynthesis. BH4 biosynthesis and poly-hydroxybutyrate biosynthesis further point to small-molecule and lipid-related cofactors and storage products. A transcription regulation term appears but likely reflects regulatory proteins linked to metabolic pathways rather than a unifying function. Overall, the dominant theme is synthesis of lipid- and lipid-derived metabolites, with some unrelated annotations likely contributing noise.","confidence":"Medium","size":24,"edges":26,"triangles":1,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":21},{"id":"GO:0055114","count":21},{"id":"GO:0006355","count":19},{"id":"GO:0006729","count":19},{"id":"GO:0045150","count":19}]},{"hash":"2219810577243453787","title":"Histone methylation and heterochromatin formation","description":"The cluster's top GO terms are dominated by histone modification and chromatin silencing: H3K9, H3K27, H4K20 trimethylation, and H3K4 trimethylation, plus rDNA heterochromatin formation and chromatin silencing. This points to epigenetic regulation and establishment/maintenance of heterochromatin as the shared function of the proteins in this cluster. A few other terms (GTPase regulation, Notch signaling) appear at low counts, but do not define the core theme. Some terms are marked obsolete, but the overall pattern remains clearly epigenetic.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0045746","count":1},{"id":"GO:0036124","count":1},{"id":"GO:0000183","count":1},{"id":"GO:1902231","count":1}]},{"hash":"1499722886669254350","title":"Retroviral Entry, Integration, and Latency","description":"The terms point to a coherent retroviral life cycle: entry into the host cell and nucleus, integration into host DNA with proviral latency, and RNA-templated DNA synthesis supporting genome replication and recombination. This pattern strongly suggests a cluster centered on retroviral replication and maintenance mechanisms.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0046718","count":12},{"id":"GO:0090502","count":12},{"id":"GO:0075732","count":12},{"id":"GO:0075713","count":12},{"id":"GO:0006310","count":12}]},{"hash":"1804429102938007472","title":"Prostaglandin and lipid metabolism in reproduction","description":"The top GO terms cluster around prostaglandin biosynthesis, P450-mediated lipid pathways (omega-hydroxylase and epoxygenase), triglyceride metabolism, and reproductive processes (prostate gland growth, sex differentiation, maternal processes in parturition). This suggests a cohesive theme of lipid-derived signaling molecules (like prostaglandins and related eicosanoids) and lipid metabolism playing roles in reproductive biology. Some terms appear peripheral (e.g., vancomycin biosynthesis), but the strongest shared signal is lipid signaling in reproduction.","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060736","count":23},{"id":"GO:0033072","count":23},{"id":"GO:0036378","count":23},{"id":"GO:0097267","count":23},{"id":"GO:0006641","count":23}]},{"hash":"773689042631063842","title":"Unknown","description":"The top terms include DNA replication and proviral integration alongside diverse developmental and glycosylation processes (root hair development, seed coat mucilage, arabinogalactan protein metabolism, insect visual primordium formation). There is no single coherent function uniting these terms, suggesting a heterogeneous or artifact cluster. ","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0080147","count":3}]},{"hash":"204776708060433025","title":"Transposons and Proviral Integration","description":"This cluster is dominated by GO terms for DNA transposition, DNA integration, and retrotransposition, along with proviral latency and symbiont/viral entry into host cells, pointing to mobile genetic elements and integrated viral/proviral processes. A few terms are more general or less connected (e.g., transcription regulation, biomineral development), but the core theme is transposon/retroelement activity and proviral integration.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046718","count":6},{"id":"GO:0075732","count":6},{"id":"GO:0075713","count":6},{"id":"GO:0006313","count":6},{"id":"GO:0015074","count":6}]},{"hash":"1124434050382389301","title":"Unknown","description":"The GO terms span diverse biological areas (DNA integration, organ development, remodeling, neuropeptide catabolism, learning, and mitosis), with no single dominant process linking them, so a precise, representative label isn\u2019t evident.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0001822","count":3},{"id":"GO:0046849","count":2},{"id":"GO:0046325","count":2},{"id":"GO:0000132","count":2}]},{"hash":"727787546652820264","title":"Embryonic and post-embryonic development","description":"Top terms cluster around organismal development across tissues (spinal cord development, hair follicle maturation, endocrine system development, post-embryonic development, multicellular growth). This suggests a unifying theme of developmental progression and tissue differentiation, with ancillary signals like translational initiation regulation and GTPase activity potentially shaping development.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0042066","count":2},{"id":"GO:0006446","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0021510","count":2}]},{"hash":"137777094708527560","title":"Ubiquitin-Dependent Antiviral Defense","description":"This cluster's top GO terms center on ubiquitin-dependent protein catabolic processes and polyubiquitination, coupled with innate immune and antiviral defense responses. The presence of autophagy and ERAD-related terms suggests these proteins participate in ubiquitin-tagged degradation pathways that coordinate antiviral responses, potentially targeting viral components or host factors during infection.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0000209","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0051865","count":4}]},{"hash":"2129174895050231509","title":"Neuronal development and axon guidance","description":"The cluster is dominated by neural development and axon guidance GO terms: multiple terms refer to neuron differentiation, nerve structure formation, and axon guidance (including semaphorin-plexin signaling, anterior/posterior axon guidance, trigeminal nerve organization, olfactory bulb development, pyramidal neuron differentiation, and sympathetic neuron projection guidance), with ERK cascade regulation as a supporting signaling mechanism. While a couple terms touch broader developmental themes (multicellular organism and heart development), the prevailing signal points to neural development and axon pathfinding.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0021637","count":3},{"id":"GO:0097491","count":3}]},{"hash":"1490144662097026954","title":"Unknown","description":"The GO terms are highly diverse, including endothelial proliferation, spliceosome-mediated splicing, DNA transposition/integration, pain response, fatty acid import, phosphorylation signaling, defense against Gram-positive bacteria, and phagolysosome assembly. There is no single dominant function or pathway linking these proteins, suggesting a mixed set of unrelated roles rather than a coherent module. Therefore, Unknown with None. ","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0048265","count":2},{"id":"GO:0015074","count":2}]},{"hash":"798569531345467936","title":"Unknown","description":"The top terms span inflammatory cytokine production, RNA processing and ribosome biogenesis, peroxisome targeting, growth hormone and sugar signaling, and multiple developmental processes (embryonic organ, skin, and leaf polarity). This combination lacks a single coherent biological theme across the proteins, making it difficult to assign a specific, representative label. ","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0002534","count":3},{"id":"GO:0000348","count":3},{"id":"GO:0010255","count":3},{"id":"GO:0048568","count":3},{"id":"GO:0043588","count":3}]},{"hash":"1630743709789453281","title":"AMPA Receptor Clustering and Glutamatergic Synaptic Regulation","description":"The GO terms point strongly to postsynaptic organization and glutamatergic signaling, including regulation of AMPA receptor clustering, glutamatergic transmission, and long-term synaptic depression. Ubiquitination-related terms (notably K63-linked) and GKAP scaffolding indicate network remodeling of the postsynaptic density affecting receptor trafficking. These together suggest a core function in glutamatergic synapse structure and signaling, hence the chosen name.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031666","count":5},{"id":"GO:0071625","count":5},{"id":"GO:2000394","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0006915","count":4}]},{"hash":"734977036359077913","title":"Unknown","description":"The top GO terms span fertilization, host-symbiont interactions, inflammatory cytokine production, RNA processing, glucose signaling, embryonic and skin development, pattern formation, peroxisome targeting, and rRNA maturation. This wide variety does not reveal a single cohesive function or pathway tying all 24 proteins together, so a specific cluster label isn\u2019t reliable.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007338","count":4},{"id":"GO:0030682","count":3},{"id":"GO:0002534","count":3},{"id":"GO:0000348","count":3},{"id":"GO:0010255","count":3}]},{"hash":"729311414101837898","title":"Unknown","description":"The top GO terms are highly diverse, including endothelial proliferation, DNA transposition, ionotropic glutamate receptor signaling, melanocyte and chondrocyte differentiation, integrin-mediated adhesion, immune cell chemotaxis, TNF ligand production, and proteoglycan catabolic processes. This broad mix suggests there is no single cohesive function or pathway tying the proteins together, so a specific, representative label cannot be confidently assigned.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":4},{"id":"GO:0006313","count":4},{"id":"GO:0035235","count":2},{"id":"GO:0045636","count":2},{"id":"GO:0033630","count":2}]},{"hash":"1335536297396090892","title":"Lipid transport and cholesterol metabolism","description":"The cluster\u2019s top GO terms cluster around lipid/ lipoprotein processes: lipoprotein transport, cholesterol storage and efflux, triglyceride transport, LDL particle clearance, galactosylceramide biosynthesis, and myelination. Together they suggest a cohesive theme of lipid trafficking and cholesterol homeostasis, with a possible tie to myelin lipid synthesis in nervous tissue.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0006682","count":2},{"id":"GO:0033344","count":2},{"id":"GO:0034197","count":2},{"id":"GO:0034383","count":2}]},{"hash":"718238550240259916","title":"Epithelial Polarity and Tight Junction Assembly","description":"The strongest terms sit around establishing epithelial cell polarity and bicellular tight junction assembly, with related apical/basal polarity maintenance and vesicle transport, suggesting a cohesive module for epithelial organization. Additional terms like brain development and photoreceptor development likely reflect tissue-specific epithelia in neural/retinal contexts but do not override the core polarity function.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0070830","count":6},{"id":"GO:0045197","count":6},{"id":"GO:0090162","count":6},{"id":"GO:0006888","count":6},{"id":"GO:0007420","count":6}]},{"hash":"681274773336650941","title":"Cell Cycle Regulation and DNA Replication","description":"This cluster is dominated by GO terms tied to cell cycle progression, proliferation control, and DNA replication/repair (e.g., cell cycle, mitotic DNA replication initiation, double-strand break repair via break-induced replication). Additional enrichment for transcriptional regulation and ribosome biogenesis aligns with coordinating growth and division. Some terms like root meristem growth, cochlea development, and bacteriochlorophyll biosynthesis appear context-specific or broader annotations, but the core theme centers on cell growth, division, and genome maintenance.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042127","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0010082","count":2},{"id":"GO:0030494","count":2}]},{"hash":"68076445005036704","title":"Proteoglycan and glycosaminoglycan biosynthesis and sulfation","description":"The cluster shows strong enrichment for proteoglycan and GAG-related processes (heparan sulfate, chondroitin sulfate) and their sulfation pathways (sulfate assimilation, N-acetylglucosamine metabolism), pointing to a coherent role in extracellular matrix component synthesis and modification. While some metabolic terms (thyroid hormone, xenobiotic metabolism) appear, the dominant signal centers on GAG/proteoglycan biosynthesis and sulfation, supporting a specific ECM-related function. Confidence in this label is High.","confidence":"","size":23,"edges":128,"triangles":248,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0000103","count":20},{"id":"GO:0030210","count":20},{"id":"GO:0030206","count":20},{"id":"GO:0009812","count":20},{"id":"GO:0042403","count":20}]},{"hash":"2264182518713642525","title":"Neuronal plasticity regulation","description":"The top GO terms are dominated by regulation of neuronal synaptic plasticity (short-term and long-term), with additional terms pointing to brain-related development (e.g., substantia nigra development) and related barrier/tight junction processes, suggesting a cluster centered on neural signaling and brain development. Some terms are general cellular processes, but the neural plasticity theme is the strongest signal.","confidence":"Medium","size":23,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048172","count":2},{"id":"GO:0008363","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0000055","count":2}]},{"hash":"1270633945982790042","title":"mRNA Splicing and Processing Complex","description":"The top GO terms point to nuclear mRNA maturation: polyadenylation, mRNA export, spliceosome-mediated splicing, and regulation of splicing, along with mRNA stabilization. These collectively indicate a cohesive module involved in mRNA processing and quality control before export, with regulatory inputs affecting splicing and poly(A) tail dynamics. This makes a focused label capturing splicing and processing functions appropriate.","confidence":"High","size":23,"edges":214,"triangles":1192,"max_degree":22,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":4},{"id":"GO:0006406","count":4},{"id":"GO:0045292","count":3},{"id":"GO:1900363","count":3},{"id":"GO:0000381","count":3}]},{"hash":"864944404785825467","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045959","count":3},{"id":"GO:0007338","count":3},{"id":"GO:0045746","count":2},{"id":"GO:0098532","count":2},{"id":"GO:0080182","count":2}]},{"hash":"1786129354807916199","title":"Neuronal signaling and cytoskeletal dynamics","description":"These proteins show enrichment for neuronal signaling and development (integrin signaling, ephrin signaling, neurotrophin/TRK signaling, neuron development) alongside cytoskeletal remodeling (actin binding) and calcium-dependent exocytosis, suggesting a cohesive role in neural signaling coupled to cytoskeletal changes. While some terms touch on muscle or immune processes, the dominant theme is neural communication and structural regulation.","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007229","count":4},{"id":"GO:0048666","count":4},{"id":"GO:0048013","count":4},{"id":"GO:1904531","count":3},{"id":"GO:0007258","count":3}]},{"hash":"161952375939616439","title":"Proviral integration and retrotransposition","description":"This cluster is dominated by GO terms tied to viral/retroelement activity: symbiont entry, viral penetration into the host nucleus, proviral latency, DNA transposition, DNA integration, and retrotransposition, all pointing to retroviral or retrotransposon life cycle and genome mobility. Additional terms like DNA-templated transcription and host response processes likely accompany these core activities, supporting a cohesive theme around genome mobility via retroelements and proviral stages.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046718","count":5},{"id":"GO:0075732","count":5},{"id":"GO:0075713","count":5},{"id":"GO:0006313","count":5},{"id":"GO:0015074","count":5}]},{"hash":"1060585878747139260","title":"GTPase-driven immune signaling and actin remodeling","description":"Top GO terms point to small GTPase signaling (Ras/Rac/Rho), lamellipodium assembly, and immune processes (B cell maturation, IL-4/IL-7 responses). The common theme is immune signaling intertwined with actin cytoskeleton remodeling, which fits both the signaling and cytoskeletal terms as well as the hematopoietic and antibody-related processes. This label captures the cluster\u2019s likely function without overgeneralizing.","confidence":"High","size":23,"edges":53,"triangles":45,"max_degree":20,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":17},{"id":"GO:0046580","count":16},{"id":"GO:0035023","count":16},{"id":"GO:0098761","count":15},{"id":"GO:0035020","count":15}]},{"hash":"169305678761487838","title":"Cytochrome P450 Lipid Hormone Biosynthesis","description":"These proteins show a strong enrichment for P450-related lipid and hormone pathways: omega-hydroxylase and epoxygenase P450 activities, prostaglandin biosynthesis, calcitriol (vitamin D) biosynthesis, and triglyceride metabolism. These terms together point to oxidation-driven lipid signaling and hormone production; other terms like sex differentiation and maternal processes fit within hormonal regulation contexts, while copper response and vancomycin biosynthesis are less central but not contradictory. Overall, the label reflects a coherent P450-mediated lipid/hormone metabolic theme.","confidence":"Medium","size":23,"edges":26,"triangles":4,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0071280","count":15},{"id":"GO:0060736","count":14},{"id":"GO:0033072","count":14},{"id":"GO:0036378","count":14},{"id":"GO:0097267","count":14}]},{"hash":"223854547425361869","title":"Central carbon metabolism and energy production","description":"The GO terms cluster around glycolysis, the TCA cycle, gluconeogenesis, and amino acid catabolism feeding acetyl-CoA, with additional lipogenic and nucleotide metabolism signals, pointing to a cohesive core of energy metabolism.","confidence":"High","size":23,"edges":248,"triangles":1667,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":10},{"id":"GO:0006094","count":8},{"id":"GO:0006096","count":7},{"id":"GO:0006552","count":6},{"id":"GO:0006814","count":6}]},{"hash":"1631234112459558847","title":"Viral entry, DNA integration, and proviral latency","description":"The top GO terms point strongly to a viral/parasite lifestyle: entry into the host cell, penetration into the host nucleus, DNA integration, and establishment of proviral latency. Additional terms about symbiont-induced host apoptosis and host signaling (peptidyl-tyrosine dephosphorylation) fit the theme of viral manipulation of host pathways. A few terms (arsenic response, prospore spindle remodeling) appear as noise but do not override the dominant pattern of viral entry, genome integration, and latency.","confidence":"High","size":23,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0039651","count":2}]},{"hash":"413682062635984307","title":"Immune signaling and apoptosis regulation","description":"Most top GO terms describe innate/adaptive immune signaling (innate immune response, lipopolysaccharide-mediated signaling pathway, T cell receptor signaling) and apoptotic processes, including positive regulation of extrinsic apoptotic signaling. A few terms about neuronal processes are present but do not dominate. Therefore the cluster is best labeled as immune signaling and apoptosis regulation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031666","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0071732","count":3},{"id":"GO:0045087","count":3},{"id":"GO:2001238","count":3}]},{"hash":"1463969341971806743","title":"Secretory granule transport and vesicle trafficking","description":"The Top Terms show a clear emphasis on intracellular transport and secretion: acrosome assembly, Golgi-to-vacuole and endosome-to-Golgi trafficking, endocytic recycling, and dense core granule transport, along with related cytoskeletal transport considerations. These collectively point to a cohesive theme of vesicle movement and secretory pathways, spanning secretory granules, the Golgi\u2013endosome network, and related trafficking processes. A few terms (DNA integration, symbiont-mediated host defenses, tissue cell number homeostasis) are peripheral or context-specific and do not override the main trafficking-focused signal.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001675","count":2},{"id":"GO:0030682","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0048873","count":1},{"id":"GO:0060052","count":1}]},{"hash":"926465203230594283","title":"Thermal and Nociceptive Signaling","description":"The cluster is enriched for GO terms related to temperature response (diet-induced thermogenesis, cellular response to temperature stimulus, response to cold) and pain perception (sensory perception of pain, detection of chemical stimulus involved in sensory perception of pain), with supporting signals from GPCR-mediated neural signaling and calcium transport, plus skin-related and endocrine processes. This points to a theme of sensory processing and stress responses, especially in thermal and nociceptive contexts, rather than a single tightly linked pathway. Confidence: Medium","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002024","count":4},{"id":"GO:0071502","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0009409","count":2},{"id":"GO:0007216","count":2}]},{"hash":"2252739589367366989","title":"Neuronal signaling and retina development","description":"The cluster is dominated by GO terms tied to neural functions: retina development in camera-type eye, regulation of sensory perception of pain, response to morphine, and regulation of membrane potential, all pointing to neuronal signaling and sensory processing. Additional terms about GTPase activity regulation and cell proliferation align with developmental processes that occur in neural/tissue contexts, especially in the developing retina. Overall, the set suggests a coherent theme around neural development and sensory signaling, with vision-related terms as a prominent anchor.","confidence":"Medium","size":23,"edges":64,"triangles":87,"max_degree":15,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060041","count":23},{"id":"GO:0008284","count":23},{"id":"GO:0043547","count":23},{"id":"GO:0008283","count":23},{"id":"GO:0090198","count":22}]},{"hash":"1335017487270726115","title":"Developmental signaling and organ morphogenesis","description":"The top GO terms point to diverse developmental processes (nervous system development, axon guidance, kidney development, spermatid development, bone ossification) and signaling pathways (ROBO, Smoothened, ERK cascade). This suggests a cluster of proteins involved in developmental signaling that guides tissue patterning and organ morphogenesis across multiple systems.","confidence":"Medium","size":23,"edges":49,"triangles":11,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002551","count":7},{"id":"GO:0043931","count":7},{"id":"GO:0043552","count":7},{"id":"GO:0070374","count":7},{"id":"GO:0007286","count":7}]},{"hash":"2248857468276062027","title":"Endothelial barrier regulation and vascular remodeling","description":"This cluster is driven by GO terms centered on endothelial function and vascular remodeling, including positive regulation of endothelial barrier establishment, angiogenesis, leukocyte tethering/rolling on the endothelium, and cell\u2013matrix interactions such as ECM adhesion and elastin catabolic processes. The presence of inflammatory signals (response to LPS, complement activation) and metabolic cues (glucose response, digestion) further supports a cohesive theme of endothelial-associated inflammation and remodeling in the vasculature.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903142","count":11},{"id":"GO:0007586","count":11},{"id":"GO:1902947","count":10},{"id":"GO:1903238","count":10},{"id":"GO:2000097","count":10}]},{"hash":"2174559097940815873","title":"Transmembrane nutrient transport and sugar sensing","description":"The cluster shows multiple GO terms tied to transmembrane transport of nutrients (vitamins, xenobiotics, glucose) and related carbohydrate responses (glucose/fructose stimuli, insulin-triggered glucose import, glucose starvation), plus a note on intestinal epithelial maintenance. This suggests a cohesive role in transporting nutrients and sensing carbohydrate availability, justifying the label.","confidence":"High","size":23,"edges":185,"triangles":682,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":18},{"id":"GO:0006855","count":18},{"id":"GO:1904659","count":17},{"id":"GO:0042149","count":17},{"id":"GO:0044381","count":17}]},{"hash":"1376460057791142763","title":"Developmental Morphogenesis and Cytoskeletal Dynamics","description":"This cluster is driven by multicellular development across tissues (neuron projection, spinal cord, lens, skeletal) and by actin-regulatory processes (Arp2/3), with supporting roles for transcription and signaling, suggesting a developmental morphogenesis program linked to cytoskeletal remodeling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1253181996697719835","title":"Proviral DNA Integration and Latency","description":"This cluster centers on proviral DNA integration, latency establishment, and related viral activities (DNA integration, viral entry/penetration into the host nucleus, DNA replication/recombination, and RNA-templated DNA biosynthesis), which together point to retroviral maintenance and genome integration in the host. Some outlier terms about placental development and symbiont interactions may reflect broader host-pathogen contexts, but the dominant pattern is proviral integration and latency mechanisms.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0001890","count":4},{"id":"GO:0046718","count":3}]},{"hash":"2009247597676967601","title":"Unknown","description":"The top GO terms cover nervous system development, immune signaling, muscle/sarcomere organization, DNA transposition/integration, endothelial proliferation, and Leydig cell differentiation, showing broad and diverse biology without a single dominant function. Because the cluster proteins appear involved in many unrelated processes, there isn't a cohesive theme to name a specific function.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0001935","count":2}]},{"hash":"1683998456814119917","title":"Retroviral entry, replication, and latency","description":"The top GO terms point to a cohesive retroviral life cycle: entry into host cells and penetration into the nucleus, reverse transcription (RNA-templated DNA synthesis), DNA integration and proviral latency, along with DNA recombination and host interactions such as RNAi suppression and apoptosis activation. This combination strongly supports a theme of viral integration and maintenance within the host genome.","confidence":"High","size":23,"edges":250,"triangles":1711,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046718","count":19},{"id":"GO:0075732","count":19},{"id":"GO:0006260","count":19},{"id":"GO:0075713","count":19},{"id":"GO:0006310","count":19}]},{"hash":"2126710963425056329","title":"Ubiquitin-mediated antiviral immune signaling","description":"The cluster combines several ubiquitination-related processes (ubiquitination, polyubiquitination, autoubiquitination, ubiquitin-dependent protein catabolic process) with immune defense terms (innate and adaptive immune responses, defense against virus, RIG-I signaling), indicating a cohesive role in ubiquitin-regulated antiviral and immune signaling pathways.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0045087","count":10},{"id":"GO:0051607","count":9},{"id":"GO:0000209","count":8},{"id":"GO:0051865","count":8}]},{"hash":"2084255125429287248","title":"Histone methylation and chromatin silencing  ","description":"The top GO terms cluster around histone methylation (H3K9, H3K27, H4K20, H3K4), heterochromatin formation, and chromatin silencing, indicating a cohesive set of epigenetic/chromatin-modifying proteins. Despite some obsolete terms, the shared theme is chromatin regulation and epigenetic silencing.  ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045746","count":2},{"id":"GO:0036124","count":2},{"id":"GO:0000183","count":2},{"id":"GO:1902231","count":2},{"id":"GO:0034773","count":2}]},{"hash":"798311541136086085","title":"Neuronal synaptic plasticity and spine morphogenesis","description":"The top GO terms cluster around synaptic signaling and structural remodeling in neurons, including long-term synaptic depression, positive regulation of excitatory postsynaptic potential, synapse structural plasticity, and dendritic spine morphogenesis, with Rac/GTPase regulation supporting actin remodeling in spines. This combination points to proteins involved in activity-dependent synaptic plasticity and spine development, which can underlie behaviors such as social interaction and vocalization.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071625","count":4},{"id":"GO:0060292","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0035021","count":3},{"id":"GO:0006508","count":3}]},{"hash":"1707149334038249366","title":"Metal ion transport and homeostasis","description":"The top GO terms cluster around zinc, iron, cobalt, and cadmium ion homeostasis and transport (e.g., intracellular zinc ion homeostasis, zinc ion transmembrane transport, iron/cobalt ion homeostasis, cadmium detox), suggesting proteins involved in metal ion regulation and trafficking. A couple of outlier terms exist, but the dominant theme is metal ion regulation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006882","count":2},{"id":"GO:1901223","count":2},{"id":"GO:0046813","count":2},{"id":"GO:0090305","count":2},{"id":"GO:0071584","count":1}]},{"hash":"1813203223573622765","title":"Sensory Perception and Ion Transport","description":"This cluster is enriched for GO terms tied to detecting stimuli (light, mechanical, chemical) and for sodium and potassium ion transmembrane transport, pointing to sensory signaling components (e.g., photoreceptors and ion channels) as a unifying theme. A few metabolic-related terms are present but much less frequent, suggesting the core function is sensory signaling rather than metabolism.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0050908","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0050966","count":2},{"id":"GO:0050968","count":2}]},{"hash":"1532295967339364637","title":"Nuclear transcription and chromatin modification","description":"The cluster is dominated by GO terms for DNA-templated transcription, RNA polymerase II transcription, and transcription elongation, as well as chromatin-modifying marks (histone methylation). This points to a nuclear module involved in transcription regulation and chromatin state control. The presence of DNA transposition and DNA integration suggests genome mobility interactions within chromatin, while ribosome biogenesis hints at broader nucleolar-associated processes; overall, the core theme is transcriptional control and chromatin modification.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0035264","count":3},{"id":"GO:0006313","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0034773","count":2}]},{"hash":"184485665127777020","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0071031","count":3},{"id":"GO:0046718","count":2},{"id":"GO:0075732","count":2}]},{"hash":"1421649732994763332","title":"DNA-templated transcription and DNA repair","description":"The top GO terms show a strong emphasis on DNA-templated transcription (regulation and the process itself) and DNA repair, including double-strand break repair, with a secondary signal from DNA transposition. This suggests a cluster of proteins involved in genome maintenance and transcriptional control, with a few unrelated metabolic terms.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0006351","count":2},{"id":"GO:1901907","count":1},{"id":"GO:0045337","count":1}]},{"hash":"1090807457916075683","title":"DNA Mobility and Developmental Processes","description":"Top GO terms cluster around DNA-templated transcription, DNA integration, and DNA transposition, indicating DNA mobility and gene regulation. Developmental and proliferation-related terms are also present, with a note on symbiont entry into host cells suggesting possible host-interaction roles. Overall, the cluster seems to mix DNA mobility/regulation with developmental and host-association themes, justifying the label.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0006313","count":3},{"id":"GO:0090307","count":2}]},{"hash":"974070933446400797","title":"Neural development and glutamatergic signaling","description":"This cluster is dominated by terms tied to nervous system development, axon guidance (e.g., midline choice point recognition), collateral sprouting, and ionotropic glutamate receptor signaling, indicating a neural development and synaptic signaling theme. Some terms about placental morphogenesis and calcium homeostasis appear as ancillary processes, but the core pattern points to neural development and glutamate-mediated signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0060672","count":4},{"id":"GO:0030682","count":4},{"id":"GO:0051563","count":3},{"id":"GO:0060670","count":3}]},{"hash":"1919988499187408749","title":"Ubiquitination and Proteasomal Degradation","description":"The top GO terms cluster around ubiquitin-dependent protein catabolic processes and ubiquitination, including SCF-dependent proteasomal degradation, indicating a core theme of protein tagging for degradation. Co-occurring terms touch on cell cycle regulation, NF-kappaB signaling, circadian rhythm, and stress-induced apoptosis, suggesting the proteins are linked to turnover control and related regulatory pathways. Overall, the dominant signal is the ubiquitin-proteasome system.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0000083","count":5},{"id":"GO:0016567","count":4},{"id":"GO:0070431","count":4},{"id":"GO:0032088","count":4}]},{"hash":"1087413541209350537","title":"Negative Regulators of Signaling and Synaptic Organization","description":"This cluster is enriched for GO terms about dampening key signaling pathways (MAPK/ERK, PI3K/AKT) and includes components linked to synaptic structure (postsynaptic density, synaptic vesicle clustering) and adhesion, with some terms related to cell cycle/kinetochores, suggesting a broader role in regulating signaling and cytoskeletal organization across cellular contexts. Confidence reflects a coherent but diverse signaling/synapse focus.","confidence":"Medium","size":22,"edges":229,"triangles":1501,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":15},{"id":"GO:0050860","count":15},{"id":"GO:0000200","count":15},{"id":"GO:0051898","count":12},{"id":"GO:2000808","count":12}]},{"hash":"1212185496522620263","title":"Transcriptional Regulation and Stress Response","description":"This cluster centers on transcriptional control (DNA-templated transcription, RNAP II regulation, mRNA capping) and cell-cycle regulation, with concurrent stress signals (immobilization, hyperosmotic). The inclusion of differentiation terms like Leydig cell differentiation and mammary gland alveolus development suggests roles in transcription-driven differentiation programs under stress, supporting this label as representative.","confidence":"High","size":22,"edges":120,"triangles":263,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006370","count":5},{"id":"GO:0035902","count":5},{"id":"GO:0033327","count":5},{"id":"GO:0060749","count":5},{"id":"GO:0006351","count":5}]},{"hash":"573063911195623300","title":"Retroviral entry, integration, and latency","description":"This cluster is driven by GO terms that describe steps of a retroviral lifecycle: entry into the host cell, penetration into the host nucleus, establishment of proviral latency, DNA recombination and DNA integration, reverse-transcription\u2013related RNA-templated DNA synthesis, and DNA replication. These terms collectively point to viral (particularly retroviral) integration and persistence within the host, with some related modulation of host RNA silencing. An outlier term related to amygdala development is likely incidental. ","confidence":"High","size":22,"edges":28,"triangles":12,"max_degree":7,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0046718","count":8},{"id":"GO:0075732","count":8},{"id":"GO:0075713","count":8},{"id":"GO:0006310","count":8},{"id":"GO:0015074","count":8}]},{"hash":"2073092491148356778","title":"Inflammation and stress signaling","description":"This cluster is dominated by immune-related and stress-response GO terms, such as JNK pathway activation (inflammatory signaling), cellular response to lipopolysaccharide, and type IV hypersensitivity, as well as execution of apoptosis. These point to a common theme of inflammatory/stress signaling cascades, with some broader development-adjacent terms that are secondary context. Overall, the core appears to be inflammation and cellular stress signaling networks.","confidence":"Medium","size":22,"edges":203,"triangles":1062,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007257","count":22},{"id":"GO:1903655","count":22},{"id":"GO:0097194","count":22},{"id":"GO:0071222","count":22},{"id":"GO:0001806","count":22}]},{"hash":"699045086433018007","title":"Chromatin organization and transcription regulation","description":"The proteins in this cluster predominantly relate to chromatin state control: histone modification, chromatin assembly and remodeling, heterochromatin formation, and transcription regulation by RNA polymerase II, including DNA replication-dependent chromatin assembly. While there are a couple of developmental terms (male gonad development, pericardium morphogenesis), the prevailing signals point to a cohesive theme of chromatin organization and transcriptional control.","confidence":"High","size":22,"edges":164,"triangles":681,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":13},{"id":"GO:0071169","count":11},{"id":"GO:0051290","count":11},{"id":"GO:0000183","count":11},{"id":"GO:0045815","count":11}]},{"hash":"1944752707587592866","title":"Neurotransmitter transport and glycinergic synaptic signaling","description":"The top GO terms cluster around brain-associated neuronal communication: dopamine and serotonin uptake, glycinergic synaptic transmission, taurine transport, and related neurotransmitter handling. The presence of thalamus development supports a brain-specific context, suggesting this cluster centers on neurotransmitter transport and glycinergic signaling in neurons. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0021794","count":5},{"id":"GO:0015824","count":4},{"id":"GO:1905847","count":4},{"id":"GO:0051583","count":4},{"id":"GO:0014064","count":4}]},{"hash":"1918619574583801652","title":"mRNA splicing regulation and stress granule localization","description":"This cluster shows strong enrichment for spliceosome-mediated splicing regulation, alternative splicing control, and mRNA polyadenylation regulation, along with mRNA stabilization and protein localization to cytoplasmic stress granules, plus IRES-dependent translational initiation. Together, they point to post-transcriptional RNA processing and stress-related translation control as a coherent theme.","confidence":"High","size":22,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":2},{"id":"GO:1900363","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0060211","count":2},{"id":"GO:1903608","count":2}]},{"hash":"934903423923719651","title":"Growth signaling and metabolic regulation","description":"The cluster features terms that converge on regulatory processes affecting cell growth and metabolism, including positive regulation of cell size, Rho signaling, and transcription regulation, along with protein homeostasis (proteasomal degradation control) and protein maturation (tetramerization, tetrapyrrole linkage). Additional metabolism-related terms like sterol biosynthesis and nitric oxide production suggest a broader role in coordinating growth signals with lipid and gas-signaling pathways. While some terms touch on development, the overall theme is regulatory control of cellular growth and core metabolic processes.","confidence":"Medium","size":22,"edges":228,"triangles":1482,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0045793","count":2},{"id":"GO:0032435","count":2},{"id":"GO:0051262","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0030259","count":2}]},{"hash":"276020602054133621","title":"Spliceosome-Driven mRNA Splicing and Polyadenylation","description":"The cluster shows strong enrichment for processes involved in mRNA maturation and regulation: spliceosome-mediated splicing (including alternative splicing), regulation of mRNA polyadenylation and tail shortening, and mRNA stabilization. These collectively indicate a group of proteins tied to post-transcriptional processing and control of mRNA fate and translation.","confidence":"High","size":22,"edges":7,"triangles":0,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1900363","count":4},{"id":"GO:0045292","count":3},{"id":"GO:0000381","count":3},{"id":"GO:0060211","count":3},{"id":"GO:0075522","count":3}]},{"hash":"666092414409320757","title":"Diverse Transmembrane Transporters","description":"This cluster centers on transmembrane transport across a broad range of substrates, including vitamins, xenobiotics/antibiotics, various ions (potassium, phosphate), and metabolites (heme, nitrite/nitrate, fucose). The common theme is membrane transport of diverse small molecules rather than a single substrate type, indicating a group of versatile transporter proteins.","confidence":"High","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035461","count":15},{"id":"GO:0006855","count":15},{"id":"GO:0042891","count":12},{"id":"GO:0046677","count":10},{"id":"GO:0071805","count":10}]},{"hash":"957425233936369579","title":"Spliceosome-Mediated mRNA Splicing Regulation","description":"The dominant GO terms point to regulation of mRNA splicing via the spliceosome, including alternative splicing and cis splicing, along with related RNA processing steps such as polyadenylation and mRNA stabilization, plus regulatory ncRNA-mediated gene silencing and translation initiation nuances, indicating a cohesive cluster of RNA processing and gene expression control functions.","confidence":"High","size":22,"edges":21,"triangles":6,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":20},{"id":"GO:0031047","count":19},{"id":"GO:0045292","count":12},{"id":"GO:1900363","count":12},{"id":"GO:0000381","count":12}]},{"hash":"1207082407921346666","title":"RNA processing and splicing regulation","description":"The top GO terms show strong enrichment for spliceosome-mediated mRNA splicing, ncRNA-mediated gene silencing, and stress granule localization, with supporting signals from rRNA processing and transcription termination steps. This points to a core theme of RNA maturation and regulation, including splicing, RNA turnover, and translational control under stress.","confidence":"High","size":22,"edges":212,"triangles":1271,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":14},{"id":"GO:0031047","count":14},{"id":"GO:1903608","count":11},{"id":"GO:0000464","count":10},{"id":"GO:0090394","count":9}]},{"hash":"2251190241872072546","title":"Cytoskeletal dynamics and membrane transport","description":"The top GO terms span cytoskeletal processes (microtubule bundle formation, microtubule polymerization) and diverse membrane transport activities (nitrite/nitrate transport, sugar transport, sodium transport, vitamin transport, and vesicle-related neurotransmitter loading). This pattern suggests proteins involved in cytoskeleton-guided intracellular trafficking and related transport functions, justifying a label centered on cytoskeletal dynamics coupled with transport. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001578","count":1},{"id":"GO:0046785","count":1},{"id":"GO:0015707","count":1},{"id":"GO:0042128","count":1},{"id":"GO:0006004","count":1}]},{"hash":"405519150187163095","title":"Epigenetic Regulation and Development","description":"The GO terms cluster around transcriptional control and chromatin modification (DNA-templated transcription, negative regulation of transcription by RNA polymerase II, histone H3-K36 methylation), with supportive developmental terms (peripheral nervous system and heart morphogenesis) and some immune-related processes, suggesting proteins involved in epigenetic regulation of developmental programs.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0003289","count":2},{"id":"GO:0007422","count":2},{"id":"GO:0003290","count":2}]},{"hash":"308469391311276107","title":"Circadian Transcription Regulation and Chromatin Modification","description":"The cluster is dominated by GO terms for DNA-templated transcription and its regulation, plus a notable presence of circadian regulation of gene expression and chromatin modification (histone deacetylation), suggesting a cohesive group of proteins involved in transcriptional control and epigenetic regulation with a circadian/muscle context.","confidence":"High","size":22,"edges":197,"triangles":1006,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":12},{"id":"GO:0070932","count":9},{"id":"GO:0051775","count":9},{"id":"GO:0045668","count":8},{"id":"GO:0060766","count":8}]},{"hash":"914889361278391344","title":"Embryonic development and tissue morphogenesis","description":"The GO terms indicate diverse developmental roles\u2014pattern formation, morphogenesis, and lineage differentiation across tissues such as cartilage, placenta, endocrine pancreas, heart, and oocytes\u2014supporting a label for embryonic development and tissue morphogenesis.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0060806","count":1},{"id":"GO:0003323","count":1},{"id":"GO:0060536","count":1}]},{"hash":"438885908338553234","title":"General cellular regulation and remodeling","description":"Top terms span cell movement, epithelial polarity, ubiquitination, RNA processing, apoptosis, and differentiation, suggesting broad regulatory and structural remodeling roles rather than a single cohesive pathway. This cluster appears to reflect maintenance and dynamic changes in cellular state rather than a specific function, hence the label.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0016477","count":6},{"id":"GO:0016567","count":5},{"id":"GO:0033028","count":5},{"id":"GO:0045444","count":5},{"id":"GO:0097284","count":5}]},{"hash":"141646486163709935","title":"Diverse metabolism and stress-response cluster","description":"The terms point to vitamins biosynthesis (biotin, menaquinone), lipid catabolism (triglyceride), and various metabolic/remodelling activities, plus redox/oxidant detoxification and stress responses (response to cold). Some terms are obsolescent, but overall the cluster centers on broad metabolic processes with associated stress and redox functions, rather than a single pathway. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0009234","count":2},{"id":"GO:0009405","count":2},{"id":"GO:0009409","count":2},{"id":"GO:0007049","count":2}]},{"hash":"678540563550949475","title":"Diverse solute transmembrane transporters","description":"This cluster is dominated by GO terms for transmembrane transport of a wide range of solutes (vitamins, xenobiotics, carbohydrates, amino acids, cysteine, potassium), indicating a group of membrane transport proteins handling diverse substrates. The appearance of an antigen-processing transport term (MHC class I pathway) can reflect TAP-like transporter activity, reinforcing the transporter-centric theme. Overall, the common function tying these proteins together is membrane transport across varied substrates.","confidence":"High","size":22,"edges":3,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0035461","count":22},{"id":"GO:0006855","count":22},{"id":"GO:0042908","count":18},{"id":"GO:0071805","count":18},{"id":"GO:0046618","count":13}]},{"hash":"1312156668051760930","title":"Melanosome and Golgi Vesicle Trafficking","description":"The cluster is best explained by a strong enrichment of vesicle- and membrane- trafficking GO terms, including endosome to melanosome transport, melanosome transport, Golgi to plasma membrane transport, Golgi organization, and general protein transmembrane transport. This points to a cohesive set of proteins involved in intracellular trafficking pathways, particularly routes to melanosomes and through the Golgi apparatus. The remaining terms (axon guidance, kidney development, GABAergic synaptic transmission) are less central to the core theme.","confidence":"High","size":22,"edges":131,"triangles":280,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035646","count":5},{"id":"GO:0090324","count":5},{"id":"GO:0007411","count":5},{"id":"GO:0001822","count":5},{"id":"GO:0071806","count":5}]},{"hash":"2048856601185292179","title":"Synapse assembly and postsynaptic signaling","description":"Proteins in this cluster co-localize with postsynaptic architecture and synaptic signaling, shown by GO terms for postsynaptic membrane assembly, gephyrin clustering in the postsynaptic density, and regulation of excitatory postsynaptic potentials, plus protein localization to synapse and cytoskeletal organization at active zones. The amyloid precursor protein metabolic process connection further ties them to neuronal synapses, while folic acid response and iodide transport are less central; overall the dominant theme is synapse assembly and transmission.","confidence":"High","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008285","count":19},{"id":"GO:0090394","count":19},{"id":"GO:2000463","count":19},{"id":"GO:0097104","count":19},{"id":"GO:0048789","count":19}]},{"hash":"486228154019568453","title":"Amino acid biosynthesis and catabolism","description":"This cluster centers on various amino acid\u2013related pathways, notably lysine biosynthesis routes (even if obsolete in GO terms), peptide/proteolytic turnover, and broader nitrogen metabolism (ureide/ allantoin pathways, purine metabolism). The presence of tRNA wobble uridine thiolation and urmylation hints at RNA modification and protein turnover components that intersect metabolic regulation. Taken together, the dominant theme is metabolism and processing of amino acids and related nitrogenous compounds, with supporting roles from RNA modification and protein turnover.","confidence":"Medium","size":22,"edges":17,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019878","count":3},{"id":"GO:0032447","count":2},{"id":"GO:0002143","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0019877","count":2}]},{"hash":"865894026114443020","title":"Glycosaminoglycan and proteoglycan biosynthesis","description":"The top GO terms are dominated by proteoglycan and sulfation-related biosynthesis (heparan sulfate, chondroitin sulfate) and related sugar metabolism (N-acetylglucosamine, sulfate assimilation), indicating a cohesive cluster centered on glycosaminoglycan production and sulfation pathways. While other metabolic terms (xenobiotic metabolism, thyroid hormone metabolism) appear, they are secondary to the core proteoglycan biosynthesis theme.","confidence":"High","size":22,"edges":225,"triangles":1426,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0000103","count":22},{"id":"GO:0030210","count":22},{"id":"GO:0030206","count":22},{"id":"GO:0009812","count":22},{"id":"GO:0042403","count":22}]},{"hash":"2062120031343294263","title":"Neural development and axon guidance signaling","description":"The cluster is enriched for neural development and axon pathfinding terms, including brain development, axon guidance, Roundabout signaling, and Hedgehog/Smoothed pathways, with supporting ERK and PI3K signaling. While there are a few non-neural developmental terms (ossification, spermatid development), the dominant theme centers on neuronal development and guidance signaling.","confidence":"Medium","size":22,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0002551","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0043552","count":3}]},{"hash":"1585250019048864421","title":"APC/C-Driven Golgi Reorganization and Ubiquitination","description":"The terms center on Golgi organization and retrograde transport, combined with APC/C-dependent catabolic processes and K11-linked ubiquitination, indicating cell-cycle\u2013regulated Golgi remodeling governed by ubiquitin signaling.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007030","count":2},{"id":"GO:0031145","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0030242","count":1}]},{"hash":"1470449099174977020","title":"Unknown","description":"The top terms span aging, inflammatory response, neural transmission, renal/angiotensin regulation of blood pressure, lipid metabolism, innervation, thyroid hormone transport, and collagen organization. This diversity provides no clear, single biological theme tying the proteins together, suggesting a heterogeneous cluster without a coherent function.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001300","count":2},{"id":"GO:0035491","count":1},{"id":"GO:0051969","count":1},{"id":"GO:0002019","count":1},{"id":"GO:0051055","count":1}]},{"hash":"1828085497284421153","title":"DNA Integration and Proviral Latency","description":"The top GO terms emphasize DNA integration, replication, recombination, and transposition, combined with notes on proviral latency and viral entry into host cells, as well as suppression of host RNAi. Together these terms define a theme around genome integration processes and virus/retroelement lifecycle, implying the cluster consists of proteins involved in DNA-level integration and associated host-virus interactions.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0030682","count":1},{"id":"GO:0046718","count":1},{"id":"GO:0075732","count":1},{"id":"GO:0006260","count":1}]},{"hash":"520935681929582419","title":"RNA Modification and Cofactor Biosynthesis","description":"This cluster prominently features RNA processing/modification terms (guanine-N7 methylation, rRNA modification, 7-methylguanosine capping) and biosynthetic pathways for cofactors and secondary metabolites (ubi quinone and biotin biosynthesis, antibiotic biosynthesis). While there are also stress- and interaction-related terms (immobilization stress, tellurium response, nodulation), the strongest shared theme is RNA modification intertwined with small-molecule biosynthesis. ","confidence":"Medium","size":22,"edges":54,"triangles":28,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":12},{"id":"GO:0036265","count":12},{"id":"GO:0035902","count":12},{"id":"GO:0000154","count":11},{"id":"GO:0006370","count":11}]},{"hash":"1077672987932068923","title":"RNA methylation and translation initiation control","description":"The cluster is enriched for RNA guanine-N7 methylation and multiple facets of translation initiation and its regulation, including formation of the preinitiation complex and IRES-dependent viral initiation. Additional terms point to ubiquitin-proteasome\u2013dependent protein turnover and cell proliferation, suggesting a cohesive theme around translational control coupled to protein homeostasis and growth. Overall, translational regulation is the strongest unifying signal among the terms.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0036265","count":6},{"id":"GO:0001731","count":5},{"id":"GO:0006446","count":4},{"id":"GO:0075525","count":4},{"id":"GO:0075522","count":4}]},{"hash":"1957197589601142510","title":"RNA capping and methylation enzymes","description":"Top GO terms are dominated by RNA modification processes (7-methylguanosine mRNA capping, RNA guanine-N7-methylation, tRNA methylation), suggesting a cluster of RNA processing enzymes. Peripheral terms like xenobiotic response and senescence appear less consistently, likely reflecting broader roles or annotation noise. Overall, the core theme is RNA capping/methylation activity among the proteins.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":11},{"id":"GO:0036265","count":11},{"id":"GO:0035690","count":9},{"id":"GO:0042220","count":8},{"id":"GO:0030488","count":7}]},{"hash":"856034614999627365","title":"Ubiquitin-Dependent Proteolysis and NF-kappaB Signaling","description":"The top GO terms are dominated by ubiquitination-related processes (ubiquitin-dependent proteolysis, autoubiquitination, multiple linkage types including K48, K63, K6, and linear), plus histone catabolic processes and links to NF-kappaB signaling and TNF pathway regulation, with a note on necroptosis modulation. This points to a cohesive theme around ubiquitin tagging and proteolysis influencing NF-kappaB\u2013mediated signaling.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0051865","count":7},{"id":"GO:0036205","count":7},{"id":"GO:1903265","count":7},{"id":"GO:0085020","count":7}]},{"hash":"1503700492659179988","title":"Vitamin and cofactor biosynthesis","description":"The top GO terms are dominated by biosynthetic processes for vitamins and cofactors (biotin, menaquinone, ubiquinone) and related metabolites, with antibiotic biosynthesis also represented, suggesting a shared theme of metabolic synthesis. While other terms touch on triglyceride catabolism and RNA processing, the strongest signal is biosynthesis/metabolism, supporting a label focused on vitamin/cofactor biosynthesis.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009102","count":11},{"id":"GO:0017000","count":11},{"id":"GO:0019433","count":9},{"id":"GO:0009234","count":9},{"id":"GO:0016049","count":8}]},{"hash":"187629119492989356","title":"Plant photorespiration and primary metabolism","description":"The GO terms are dominated by processes tied to plant photorespiration and related carbon/nitrogen metabolism, including glycolate/glyoxylate pathways, oxidative photosynthetic carbon flux, and amino acid biosynthesis/assimilation. This suggests a cluster centered on plant photorespiration with connected metabolic activities, rather than a single isolated pathway.","confidence":"High","size":22,"edges":67,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0009854","count":14},{"id":"GO:0080114","count":14},{"id":"GO:0019516","count":14},{"id":"GO:0001561","count":14},{"id":"GO:0046296","count":14}]},{"hash":"117205031291897599","title":"Unknown","description":"Top terms cover a wide range of tissues and processes (prostatic bud regulation, chondrocyte development, GDNF receptor signaling, innervation, glomerular basement membrane development, esophagus smooth muscle contraction, choline biosynthesis, lipoteichoic acid biosynthesis, FGFR signaling regulation, and glomerular filtration) with no single unifying function or pathway. This diversity suggests no coherent cluster theme can be assigned, so a definitive label is not warranted.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060686","count":4},{"id":"GO:0002063","count":4},{"id":"GO:0035860","count":4},{"id":"GO:0060384","count":4},{"id":"GO:0032836","count":4}]},{"hash":"593984813365060767","title":"Inflammation and ECM remodeling regulators","description":"The terms point to innate immune activation (lipopolysaccharide response, classical complement activation) and leukocyte recruitment, plus vascular remodeling processes (angiogenesis, cell-matrix adhesion, elastin turnover). A subset also touches transcription regulation, but the dominant theme appears to be inflammatory signaling coupled with extracellular matrix and vascular remodeling, rather than a singular enzymatic function. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":4},{"id":"GO:0045944","count":4},{"id":"GO:0000122","count":4},{"id":"GO:1902947","count":3},{"id":"GO:1903238","count":3}]},{"hash":"459859697456670208","title":"Temperature and Immune Stress Signaling","description":"The top GO terms cluster around temperature stress responses (response to cold/heat) and protein ubiquitination, along with transcriptional regulation related to heat stress. Innate immune signaling is also represented (NOD1/2 pathways, myeloid apoptotic process) plus broader signaling and lipid metabolism processes, suggesting a mix of stress-response and immune-related functions rather than a single cohesive role. This points to a high-level theme of stress signaling with immune involvement, rather than a narrowly defined function cluster. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009409","count":4},{"id":"GO:0009408","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0061408","count":4},{"id":"GO:0033028","count":4}]},{"hash":"479598787408578","title":"Transposons and proviral genome integration","description":"The dominant GO terms are about DNA transposition, retrotransposition, DNA integration, and proviral latency, pointing to a cluster of proteins involved in transposable elements and viral genome integration into the host. Additional terms related to symbiont/viral entry into host cells support a viral integration theme, suggesting these proteins function in mobilizing or integrating genetic material rather than typical metabolism. Confidence reflects the strong, coherent signal toward transposition and proviral integration.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0039651","count":4}]},{"hash":"1412688508724104116","title":"Regulation of cellular signaling and growth","description":"The top GO terms point to regulation of signaling pathways (positive/negative regulation of GTPase activity), regulation of cell polarity, and control of proliferation and apoptosis, suggesting these proteins function as regulators of cellular signaling and growth rather than a single concrete pathway. The presence of sporulation-related and lipid biosynthesis regulation terms indicates heterogeneity, so the label reflects the dominant theme of regulatory activity rather than a specific process.","confidence":"Low","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"lysosome organization","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:2001241","count":3},{"id":"GO:0048147","count":3},{"id":"GO:0031322","count":3},{"id":"GO:2001246","count":3}]},{"hash":"225011636307322639","title":"Unknown","description":"The GO terms are scattered across diverse processes\u2014development of multiple tissues (lung connective tissue, nipple and eye development, parturition) plus unrelated cellular activities (mitochondrial fission regulation, dsRNA response, T cell chemotaxis). There isn\u2019t a single coherent function or pathway tying these proteins together, so an Unknown label with no confidence is appropriate.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090141","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0060658","count":2},{"id":"GO:0007567","count":2},{"id":"GO:0032464","count":1}]},{"hash":"1372030130395838261","title":"Neuron\u2013glia adhesion and synaptic regulation","description":"This cluster centers on neuron-glia interactions, glial migration/differentiation, and synaptic regulation, evidenced by terms about neuronal-glial adhesion during radial glia-guided migration, astrocyte differentiation, synaptic localization affecting plasticity, and vesicle transport/endocytosis. Cytoskeletal remodeling (lamellipodium morphogenesis) and SMAD signaling further support development-related neuron-glia communication. Some terms (DNA transposition) may be incidental noise.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":3},{"id":"GO:2000394","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0006898","count":2}]},{"hash":"698451992336472255","title":"Proviral integration and retrotransposition","description":"The top GO terms point to viral entry and genome integration events (symbiont entry, viral penetration into the nucleus, proviral latency, DNA integration, transposition, retrotransposition, DNA-templated transcription) indicating a proviral/retrotransposon\u2013host interaction theme. Additional terms on ubiquitination and negative regulation of apoptosis suggest host-pathogen interaction modulation, reinforcing a cohesive proviral/retrotransposon activity cluster.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046718","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0039651","count":4}]},{"hash":"2195552809280946020","title":"Vascular development and blood pressure regulation","description":"The cluster\u2019s GO terms center on vascular biology: angiogenesis, NO biosynthesis, blood pressure regulation, coagulation, and calcium signaling, with kidney development and mechanical stimulus response suggesting vascular development and function. Some terms like pain perception and synapse assembly may be ancillary signals, but the dominant theme is blood vessel formation and regulation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045777","count":5},{"id":"GO:0045429","count":4},{"id":"GO:0001822","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0007596","count":4}]},{"hash":"2146610637810669904","title":"Mitotic Cytoskeleton and Contractile Ring Assembly","description":"These proteins cluster around actin filament bundles involved in the mitotic contractile ring and cytokinesis, with supporting terms on centrosome localization and GTPase regulation. The pattern suggests a cohesive theme of mitotic cytoskeletal dynamics and cell division machinery, with a few development-related division terms that fit the broader mitotic context.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007339","count":2},{"id":"GO:0070493","count":2},{"id":"GO:1903478","count":2},{"id":"GO:0021873","count":2},{"id":"GO:0051661","count":2}]},{"hash":"1255347002323525904","title":"Carbohydrate and lipid metabolism cluster","description":"Top GO terms indicate broad metabolic activity centered on carbohydrate and lipid pathways. Terms include fatty acid biosynthetic process, fructose and galactose catabolic/biosynthetic steps, xylitol and D-xylulose 5-phosphate metabolism, and amino acid catabolism via Ehrlich pathway, suggesting enzymes involved in central carbon metabolism and lipid biosynthesis. Additional terms like prostaglandin metabolic process point to lipid signaling-related metabolism, and extracellular negative regulation of signal transduction hints at regulatory roles tied to metabolism. Taken together, the cluster appears to group proteins involved in diverse metabolic processes with a common energy- and lipid- metabolism orientation.","confidence":"Medium","size":21,"edges":166,"triangles":707,"max_degree":20,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0006633","count":9},{"id":"GO:0019518","count":8},{"id":"GO:0051160","count":7},{"id":"GO:0046370","count":7},{"id":"GO:0046688","count":7}]},{"hash":"1780396660755782299","title":"Neuronal signaling and cytoskeleton remodeling","description":"These proteins cluster around neural signaling and behavior-related GO terms (vocalization behavior, sensory perception of sound, cellular response to morphine, grooming behavior) and core signaling/cytoskeletal processes (GTPase activation, regulation of Rho signaling, actin cytoskeleton organization, exocytosis, protein dephosphorylation). The co-occurrence suggests a module coordinating synaptic vesicle trafficking and cytoskeletal remodeling that underpins neuronal communication and behavioral outputs.","confidence":"High","size":21,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0071625","count":8},{"id":"GO:0007605","count":8},{"id":"GO:0090630","count":7},{"id":"GO:0030036","count":7},{"id":"GO:0035023","count":7}]},{"hash":"1753612971598787385","title":"Metabolic and Stress Response","description":"The top GO terms cluster around core metabolism and stress-related processes: redox homeostasis, thiamine biosynthesis, and nitrate assimilation suggest coordinated metabolic activity, while the unfolded protein response indicates proteostasis under stress. Some terms about cell cycle progression and drug response appear as outliers, but the dominant theme points to metabolism coupled with stress adaptation. This justifies a label focusing on metabolic and stress-related functions rather than a single, narrow process.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0009228","count":4},{"id":"GO:0045454","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0031145","count":3}]},{"hash":"1116258512788178359","title":"Diverse solute transporters (sugars, ions, vitamins)","description":"The cluster\u2019s top GO terms are all related to transmembrane transport of various solutes\u2014nitrite/nitrate, multiple sugars (galactose, arabinose), phosphate ions, sodium ions, and vitamin transport\u2014plus a vesicular neurotransmitter loading process, pointing to membrane transporter proteins with broad substrate specificity. While there is one neuronal-specific term, the overarching theme is solute transport across membranes, suggesting a cohesive transporter-focused group. ","confidence":"Medium","size":21,"edges":12,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0015707","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0006004","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0042891","count":3}]},{"hash":"1641948866317374764","title":"Innate immune signaling with translation components","description":"The top GO terms cluster around innate immune processes (innate immune response, NOD2 signaling pathway, interferon signaling, and NF-kappaB regulation), suggesting a core theme of innate immune signaling. The presence of translation-related terms (translation, ribosome biogenesis) and ubiquitination hints at supporting cellular machinery, but the immune signaling terms are central, supporting a representative label focused on innate immunity with associated translational processes.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0070431","count":2},{"id":"GO:0060348","count":2},{"id":"GO:0060335","count":2}]},{"hash":"751838118194439438","title":"Ribosome biogenesis and Cajal body organization","description":"The top GO terms are dominated by ribosomal subunit biogenesis for both large and small subunits, and a term for Cajal body organization, suggesting a shared role in ribosome production and nuclear RNA processing. Other terms related to transcription regulation and development appear incidental, but the core theme centers on ribosome assembly and nuclear/nucleolar organization.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":1},{"id":"GO:0042274","count":1},{"id":"GO:0001935","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0030576","count":1}]},{"hash":"4064391209759844","title":"Unknown","description":"The top GO terms cover immune signaling, eye development, apoptosis, segmentation, epithelial migration, and post-translational regulation, spanning multiple tissues and processes. There is no single cohesive function tying these proteins together, and the network shows no edges, suggesting the annotations may be incidental rather than a functional module. ","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002467","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0070306","count":2},{"id":"GO:1902108","count":2},{"id":"GO:0035289","count":2}]},{"hash":"252192042418063691","title":"Prostaglandin synthesis and inflammatory signaling","description":"This cluster is dominated by prostaglandin biosynthesis, with multiple inflammatory-regulatory signals such as negative regulation of TNF signaling, MCP-1 production, and JNK activity, plus glucocorticoid response. Oxidative stress management (glutathione metabolism, oxidant detox) also appears, suggesting a cohesive theme of prostaglandin-driven inflammatory signaling balanced by redox defenses.","confidence":"High","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":18},{"id":"GO:0098869","count":14},{"id":"GO:0071638","count":13},{"id":"GO:2000469","count":13},{"id":"GO:0006749","count":13}]},{"hash":"1529143479710281863","title":"Unknown","description":"The terms are very diverse, including DNA transposition, endosome organization, ribosomal export, otolith morphogenesis, myelination, and inflammatory signaling. There is no clear, dominant shared function linking most proteins, so a coherent label cannot be confidently assigned.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0007032","count":2},{"id":"GO:0000055","count":2},{"id":"GO:0032474","count":2},{"id":"GO:0042552","count":2}]},{"hash":"124478332783307626","title":"Unknown","description":"The top GO terms are mixed: DNA transposition (5) and related hydrolysis (4) are dominant, but there are also skin development, multicellular development, mRNA transport, GTPase signaling, pigmentation, and even karyogamy terms. This lack of a single cohesive theme makes it hard to assign a specific, representative function to the cluster, so the label Unknown is most appropriate.","confidence":"","size":21,"edges":20,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":5},{"id":"GO:0090305","count":4},{"id":"GO:0000742","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0007275","count":2}]},{"hash":"1652876216771803111","title":"Regulation of mRNA splicing and polyadenylation","description":"The top terms center on mRNA splicing (via spliceosome), alternative splicing regulation, mRNA polyadenylation and 3' tail shortening, and stress-related mRNA stability, with an additional note on IRES-dependent translation initiation. These together point to a cluster of proteins involved in RNA processing and post-transcriptional regulation, especially splicing and polyadenylation control, under stress conditions and in translation initiation contexts.","confidence":"High","size":21,"edges":181,"triangles":989,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":14},{"id":"GO:0006378","count":12},{"id":"GO:0045292","count":11},{"id":"GO:1900363","count":11},{"id":"GO:0000381","count":11}]},{"hash":"1755128135721968466","title":"Developmental signaling and organogenesis","description":"The top GO terms point to diverse developmental processes (brain and inner ear development, male gonad development, blood vessel maturation, locomotory behavior, equator specification) along with regulatory signaling (signal transduction involved in regulation of gene expression). This pattern suggests a broad developmental and developmental-regulatory role across multiple tissues, rather than a single, specific function; the ion transport term is an outlier but can relate to neuronal development. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0023019","count":2},{"id":"GO:0048839","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0008584","count":2}]},{"hash":"680002945888412096","title":"Cell Cycle and DNA Replication Regulation","description":"The top terms are dominated by DNA replication and centrosome cycle, pointing to cell division control as the core function of this cluster, with some related signaling and developmental terms appearing as secondary associations.","confidence":"Medium","size":21,"edges":10,"triangles":0,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0043552","count":13},{"id":"GO:0010571","count":12},{"id":"GO:2000810","count":12},{"id":"GO:0048813","count":12},{"id":"GO:0007098","count":12}]},{"hash":"1505234042196809777","title":"Viral Entry, DNA Integration, and Proviral Latency","description":"These terms collectively point to a function in viral infection and mobile genetic-element activity (DNA integration, retrotransposition, proviral latency) with related steps like entry into the host cell and nuclear penetration.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":13},{"id":"GO:0046718","count":12},{"id":"GO:0075732","count":12},{"id":"GO:0075713","count":12},{"id":"GO:0006313","count":12}]},{"hash":"1190093201897009769","title":"Auditory Neurotransmission and Cochlear Development","description":"This cluster centers on the molecular processes underlying hearing: detection of sound stimuli, cochlear development, and synaptic transmission in auditory pathways (membrane depolarization, EPSPs/IPSPs, and regulation of nerve impulse/action potential). A few terms are peripheral (cocaine response, amyloid regulation), but the dominant theme is auditory neuronal signaling and cochlear maturation.","confidence":"Medium","size":21,"edges":40,"triangles":23,"max_degree":18,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":13},{"id":"GO:0042220","count":9},{"id":"GO:0051899","count":8},{"id":"GO:1905906","count":8},{"id":"GO:0060080","count":8}]},{"hash":"1244286147689662531","title":"Diverse membrane nutrient transporters","description":"The GO terms center on transmembrane transport of multiple substrates (myo-inositol, pantothenate, biotin, glucose, nitrite/nitrate) and vitamin transport, suggesting the proteins function broadly as membrane transporters rather than a single substrate-specific group.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015798","count":4},{"id":"GO:0015887","count":4},{"id":"GO:0008292","count":4},{"id":"GO:0071436","count":4},{"id":"GO:0015878","count":4}]},{"hash":"1753699385281469913","title":"Broad-substrate membrane transporters","description":"The top terms are dominated by transmembrane transport across membranes for a variety of substrates (vitamins, xenobiotics, antibiotics, potassium, carbohydrates, amino acids, cysteine), suggesting a cluster of broadly acting transporter proteins. An outlier term about MHC class I antigen processing appears and a mitochondrial cytochrome complex assembly term, but the central theme remains membrane transport. ","confidence":"Medium","size":21,"edges":6,"triangles":4,"max_degree":3,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0035461","count":14},{"id":"GO:0006855","count":14},{"id":"GO:0046677","count":12},{"id":"GO:0071805","count":10},{"id":"GO:0046618","count":9}]},{"hash":"875617659074937862","title":"DNA Damage Response and Transcription Regulation","description":"The terms cluster around transcription initiation (RNA polymerase II promoter clearance, open complex formation) and RNA processing, paired with DNA repair and UV protection (nucleotide-excision repair, SOS response). This points to a coordinated DNA damage response that modulates transcription, with some development-related terms likely reflecting broader regulatory roles in tissue development.","confidence":"High","size":21,"edges":92,"triangles":149,"max_degree":19,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001111","count":9},{"id":"GO:0009650","count":9},{"id":"GO:0000184","count":9},{"id":"GO:0006268","count":9},{"id":"GO:0006289","count":9}]},{"hash":"185240767737847551","title":"DNA repair and damage response","description":"This cluster is dominated by DNA repair and genome maintenance terms (base-excision repair, DNA recombination, DNA catabolic process) and includes apoptosis, which points to a coordinated DNA damage response. Additional terms like mRNA stability regulation and redox homeostasis suggest broader stress-response roles, while corneocyte development may reflect tissue-specific annotations. Overall, the core theme appears to be maintenance of genomic integrity in the face of damage.","confidence":"Medium","size":21,"edges":31,"triangles":8,"max_degree":8,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0090502","count":9},{"id":"GO:0006310","count":9},{"id":"GO:0045454","count":8},{"id":"GO:0043488","count":8},{"id":"GO:0006915","count":8}]},{"hash":"898725577360869351","title":"Sugar and xenobiotic transmembrane transport","description":"The cluster is enriched for transmembrane transport of vitamins, xenobiotics, glucose, and fructose, with related responses to glucose starvation and insulin-stimulated glucose import, pointing to roles in nutrient uptake and carbohydrate signaling. Additional terms on osmotic stress and intestinal epithelial maintenance suggest gut-associated transport/homeostasis. Overall, the core theme is membrane transport of sugars and xenobiotics.","confidence":"High","size":21,"edges":181,"triangles":885,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":18},{"id":"GO:0006855","count":18},{"id":"GO:1904659","count":13},{"id":"GO:0042149","count":13},{"id":"GO:0044381","count":13}]},{"hash":"1019214075742638712","title":"Neural development with innate immune signaling","description":"The top GO terms show strong emphasis on neural development processes (axonogenesis, axonal fasciculation, synapse assembly, myelination) along with innate immune responses (response to LPS, dsRNA, general innate immunity, defense against Gram-positive bacteria) and sensory organ morphogenesis (otolith morphogenesis). Together they suggest a cluster of proteins involved in neural/sensory development that also participate in immune signaling pathways, rather than a single cohesive metabolic or structural function. Therefore the label reflects the dual theme of nervous system development and innate immunity.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0014068","count":7},{"id":"GO:0051965","count":7},{"id":"GO:0032474","count":6},{"id":"GO:0042552","count":6},{"id":"GO:0007413","count":6}]},{"hash":"108273223325660094","title":"Acrosome reaction and zona pellucida interaction","description":"The top GO terms are dominated by fertilization-related processes, notably regulation of the acrosome reaction and penetration of the zona pellucida, pointing to sperm\u2013egg interaction as the central theme of this cluster. Other terms are more general or ancillary, but the fertilization-related terms strongly anchor the cluster\u2019s function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0007341","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0019885","count":3},{"id":"GO:0060054","count":3}]},{"hash":"1670987637999271037","title":"Unknown","description":"This cluster shows a broad mix of GO terms (defense response, growth, ribosome biogenesis, brain development, splicing, adhesion, etc.) and has no connecting edges, indicating no cohesive functional theme. Therefore, Unknown.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0050830","count":9},{"id":"GO:0035264","count":7},{"id":"GO:0014068","count":6},{"id":"GO:0042254","count":4},{"id":"GO:0007420","count":4}]},{"hash":"131494745263144472","title":"Fatty acid metabolism and transport","description":"The top terms cluster around fatty acid metabolism across various chain lengths (long-, very long-, medium-chain), including import into the cell and fatty-acyl-CoA processing, which together suggest a lipid metabolism-focused group. Some terms (nonribosomal peptide biosynthesis and phenylpropanoid metabolism) are peripheral or reflect broader metabolic capabilities, but the dominant pattern is lipid/fatty acid metabolism.","confidence":"Medium","size":21,"edges":37,"triangles":7,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1902987","count":18},{"id":"GO:0043041","count":17},{"id":"GO:0019654","count":17},{"id":"GO:0090410","count":17},{"id":"GO:0001676","count":17}]},{"hash":"275266397547090724","title":"Cardiovascular and neural development with metabolic stress","description":"Top GO terms indicate a core theme of heart and nervous system development (heart development, angiogenesis, nervous system development) with accompanying metabolic and mitochondrial signaling (response to amino acid starvation, response to fatty acid, regulation of mitochondrial membrane potential) and ion-channel organization (clustering of voltage-gated potassium channels). This suggests a coherent cluster of proteins involved in developmental processes of the heart and nervous system coupled with metabolic stress responses and mitochondrial maintenance. ","confidence":"Medium","size":21,"edges":32,"triangles":14,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":7},{"id":"GO:0034198","count":7},{"id":"GO:0097274","count":7},{"id":"GO:0001525","count":6},{"id":"GO:0045163","count":6}]},{"hash":"826644400974978415","title":"Neural development and synaptic signaling","description":"The top GO terms center on brain-related development (e.g., substantia nigra development) and synaptic function (excitatory postsynaptic potential) along with signaling pathways (ERK cascade), suggesting a cohesive theme around neural development and neuronal communication; several immune-related terms appear as outliers, but the neural pattern is most representative.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0060079","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0002551","count":2}]},{"hash":"1178859554686243541","title":"Angiogenesis and ECM Remodeling","description":"The GO terms cluster around vascular development and extracellular matrix dynamics: angiogenesis, collagen fibril organization, endothelial cell migration, elastic fiber assembly, and regulation of vascular permeability, with signaling modulation in ERK and Notch pathways contributing to vascular growth. A smaller signal for adaptive immune response is present but appears secondary to the vascular/ECM theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0043536","count":2}]},{"hash":"2279564431986855745","title":"Embryonic and Tissue Development","description":"This cluster centers on GO terms tied to development and morphogenesis across multiple tissues\u2014skeletal, vascular, neural, ocular lens, and extracellular matrix organization\u2014indicating a shared theme of tissue formation and differentiation in multicellular organisms. A couple of terms touch on immune signaling or apoptosis, but the dominant pattern is developmental processes.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":5},{"id":"GO:0001525","count":4},{"id":"GO:0002250","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0031175","count":4}]},{"hash":"1123071150639166470","title":"DNA Damage Response and Cell Death","description":"This cluster is dominated by terms tied to DNA integrity maintenance and fate decisions, including DNA recombination, base-excision repair, and DNA catabolic process, plus apoptotic process. Additional signals like regulation of mRNA stability and redox homeostasis fit a coordinated stress response linked to DNA damage and cell fate choices. Overall, the proteins likely participate in sensing and repairing DNA damage and coordinating apoptosis when damage is severe.","confidence":"High","size":21,"edges":161,"triangles":621,"max_degree":20,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":8},{"id":"GO:0045454","count":7},{"id":"GO:0090502","count":7},{"id":"GO:0043488","count":7},{"id":"GO:0006915","count":7}]},{"hash":"635379600569142860","title":"Vitamin D metabolism and P450 lipid pathways","description":"The cluster is dominated by GO terms tied to vitamin D biology (response to vitamin D, calcitriol biosynthetic process) and P450-mediated lipid metabolism (omega-hydroxylase and epoxygenase pathways), with supporting signals from prostaglandin biosynthesis and triglyceride metabolism, plus reproductive-associated terms (sex differentiation, maternal parturition, prostate growth). The presence of an outlier term (vancomycin biosynthetic process) likely reflects annotation noise rather than a true functional link. Thus the label reflects the core theme of vitamin D\u2013related metabolism and P450 lipid pathways.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":19},{"id":"GO:0060736","count":18},{"id":"GO:0033072","count":18},{"id":"GO:0036378","count":18},{"id":"GO:0097267","count":18}]},{"hash":"1198551519012552600","title":"Fatty acid metabolism and related catabolic pathways","description":"The cluster\u2019s top GO terms cluster around fatty acid metabolism (long-, very long-, and medium-chain), fatty acid import, and related catabolic processes, with additional links to small-molecule degradation such as phenylacetate, malonate, and phenylpropanoid metabolism, plus menaquinone biosynthesis. This suggests proteins involved in lipid utilization and energy-yielding metabolism, with some broader aromatic compound degradation. While not all terms fit a single pathway, the fatty acid and related catabolic theme is the strongest cohesive signal.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":4},{"id":"GO:0043041","count":3},{"id":"GO:0019654","count":3},{"id":"GO:0090410","count":3},{"id":"GO:0001676","count":3}]},{"hash":"785981015841542772","title":"Vascular inflammation and endothelial activation","description":"The proteins in this cluster show enrichment for innate immune responses to lipopolysaccharide, leukocyte recruitment, and complement activation, along with vascular-related processes such as angiogenesis, endothelial barrier establishment, and elastin remodeling. This points to a cohesive theme of inflammation-driven vascular remodeling and endothelial activation rather than a single isolated pathway.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":9},{"id":"GO:1902947","count":8},{"id":"GO:1903238","count":8},{"id":"GO:2000097","count":8},{"id":"GO:0071333","count":8}]},{"hash":"242890679698636704","title":"Complement-driven innate immunity and tissue remodeling","description":"This cluster is dominated by GO terms for complement activation (lectin and classical pathways) and responses to lipopolysaccharide, along with processes related to leukocyte adhesion, angiogenesis, and elastin/matrix remodeling, pointing to innate immune activation coupled with extracellular matrix remodeling. Some transcription-regulation terms appear less central to the main theme. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0000122","count":8},{"id":"GO:1902947","count":7},{"id":"GO:1903238","count":7},{"id":"GO:2000097","count":7}]},{"hash":"715153692139353345","title":"GTPase signaling and regulatory processes","description":"The cluster is dominated by GO terms about regulating small GTPase signaling, especially Rho and Ras pathways (e.g., regulation of Rho protein signal transduction; positive regulation of GTPase activity; negative regulation of Ras protein signal transduction). Additional terms point to broader regulatory roles, including protein dephosphorylation, inhibition of apoptosis, autophagy (aggrephagy), and innate immune signaling, suggesting proteins that modulate signaling cascades and cellular homeostasis with immune and survival implications. Confidence in this thematic grouping is Moderate.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0019915","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0045060","count":2}]},{"hash":"2206841807965279359","title":"RNA Processing and Ribosome Biogenesis","description":"This cluster is enriched for RNA metabolism and ribosome-related processes: mRNA splicing (spliceosome), regulation of alternative splicing, transcription, ribosome biogenesis, and translation reinitiation, pointing to general gene expression and ribosome assembly functions. Some terms are context-specific (viral mRNA export, histone methylation regulation) but the dominant theme is RNA processing and ribosome assembly.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0000398","count":2},{"id":"GO:1900112","count":2}]},{"hash":"1925252959745892315","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"The cluster is dominated by GO terms related to actin filament bundle assembly, cell migration, lamellipodium morphogenesis, and establishment of epithelial cell polarity, indicating a theme of cytoskeleton-driven motility and polarity. Additional terms for EGFR signaling and small GTPase pathways support coordinated cytoskeletal remodeling, with a note of developmental branching processes, but the core signal is actin-based movement and organization.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051017","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0090162","count":5},{"id":"GO:0007173","count":4},{"id":"GO:0007264","count":4}]},{"hash":"1038984668322698824","title":"Retroviral integration and proviral latency","description":"The top GO terms cluster around stages of viral/symbiont interaction with the host genome\u2014entry into the host cell, nuclear penetration, and establishment of integrated proviral latency\u2014together with DNA integration, transposition, and reverse-transcription\u2013related processes. This combination most strongly points to retroviral integration and proviral latency mechanisms as the shared function of these proteins.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0046718","count":5},{"id":"GO:0075732","count":5},{"id":"GO:0075713","count":5},{"id":"GO:0015074","count":5},{"id":"GO:0039651","count":5}]},{"hash":"773852310756624696","title":"Unknown","description":"The top GO terms span diverse cellular roles (DNA integration, RNA splicing, collagen organization, endosomal trafficking, mechanical stimulus response, and kinase regulation), with no obvious unifying function among the 21 proteins. Therefore it's not possible to assign a cohesive label.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0010596","count":2}]},{"hash":"7338809783558079","title":"Inflammation-Driven ECM Remodeling and Coagulation","description":"The top terms cluster around innate immune activation (neutrophil-mediated killing, leukocyte tethering) and extracellular matrix breakdown (elastin and collagen catabolism) plus regulation of fibrinogen, suggesting inflammation-associated tissue remodeling and coagulation. A couple of less coherent terms (DNA transposition, transcription regulation) appear less central to this theme, but do not override the dominant signal. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0006313","count":3},{"id":"GO:1903238","count":3},{"id":"GO:0060309","count":3},{"id":"GO:0032078","count":3}]},{"hash":"1829008229542172148","title":"Symbiont-driven host transcriptional suppression","description":"The top GO terms point to a functional theme where a symbiont modulates host gene expression, with explicit terms for symbiont-mediated degradation of host mRNA and suppression of host gene expression, along with transcriptional regulation (DNA-templated transcription and negative regulation of RNA polymerase II). While a few terms (heart development, iron homeostasis, CO2 transport) are more general, the strongest signals anchor the cluster to host transcriptional control influenced by symbionts.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":3},{"id":"GO:0006313","count":2},{"id":"GO:0039595","count":2},{"id":"GO:0039657","count":2},{"id":"GO:0000122","count":2}]},{"hash":"200027981143609852","title":"Embryonic organ morphogenesis","description":"The top GO terms are dominated by embryonic development and organ formation, including heart looping, retina development, ventricular septum development, and limb/digit morphogenesis, plus anterior/posterior axis specification. This points to a cohesive theme of embryonic tissue patterning and organogenesis. A couple of terms (e.g., estrogen receptor signaling, Golgi-ER transport) are less central but do not negate the core developmental signal.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001947","count":2},{"id":"GO:0046600","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0042733","count":2},{"id":"GO:0035115","count":2}]},{"hash":"2156094753518350938","title":"Ubiquitin-Mediated NF-kappaB Signaling","description":"This cluster is strongly enriched for ubiquitin-dependent protein catabolic processes and regulators of NF-kappaB signaling, including activation of NF-kappaB-inducing kinase, I-kappaB phosphorylation, and TNF-mediated pathways, as well as autoubiquitination and regulation of downstream kinase cascades like JNK. While there are histone modification terms present, the dominant signal ties ubiquitination to NF-kappaB pathway control.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0070535","count":4},{"id":"GO:2000620","count":4},{"id":"GO:0007250","count":4},{"id":"GO:0051865","count":4}]},{"hash":"1337217209017360623","title":"Embryonic and placental morphogenesis","description":"Top GO terms cluster around embryonic development and organogenesis, especially placenta/trophoblast formation, left\u2013right patterning, cartilage morphogenesis, and epithelial-to-mesenchymal transitions in heart development, with additional but related endocrine pancreas development. A couple of terms (DNA transposition, spliceosome activity) appear ancillary and do not define the main theme. Overall, the cluster reflects embryonic development with a placental emphasis.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060536","count":3}]},{"hash":"2107191837802210586","title":"Embryonic tissue development and morphogenesis","description":"The top GO terms point to developmental processes and tissue remodeling in embryogenesis\u2014biomineral tissue development, cartilage morphogenesis, EMT involved in endocardial cushion formation, left-right patterning, placental and endocrine system development, pancreatic cell development, and collagen catabolic/remodeling. These collectively suggest a cohesive theme of organogenesis and extracellular matrix remodeling during development.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031214","count":5},{"id":"GO:0030194","count":5},{"id":"GO:0030574","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0060806","count":5}]},{"hash":"1566775875176270703","title":"Collagen ECM Biosynthesis and Development","description":"The top GO terms point to collagen biosynthetic process and collagen fibril organization, indicating extracellular matrix (ECM) construction/remodeling. Additional terms for immune regulation and various developmental processes (nervous system development, labyrinthine layer morphogenesis, collateral sprouting) suggest the proteins also participate in immune modulation and growth-related pathways, likely linking ECM dynamics to developmental contexts.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":6},{"id":"GO:0010951","count":3},{"id":"GO:0030199","count":2},{"id":"GO:0001869","count":2},{"id":"GO:0032964","count":2}]},{"hash":"1697837171892761829","title":"Ribosome biogenesis and translation machinery","description":"Most enriched terms cluster around protein synthesis: translation, ribosome biogenesis, ribosomal processes (assembly/disassembly/termination), and translational fidelity. This suggests a cohesive group of proteins involved in ribosome function and the translation machinery, with a few ancillary terms like mitochondrial translation. ","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":13},{"id":"GO:0042254","count":4},{"id":"GO:0006415","count":3},{"id":"GO:0032790","count":3},{"id":"GO:0045903","count":3}]},{"hash":"832744050291364840","title":"RNA Methylation and Capping","description":"The cluster is dominated by RNA processing-related terms (m7G capping, RNA guanine-N7 methylation, tRNA wobble modification, and arginine methylation), indicating a set of RNA-modifying proteins; a few outliers exist but the shared function is RNA modification.","confidence":"Medium","size":20,"edges":19,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":6},{"id":"GO:0036265","count":6},{"id":"GO:0042418","count":5},{"id":"GO:0010243","count":5},{"id":"GO:0031100","count":5}]},{"hash":"1900526852950049426","title":"Organogenesis Signaling Network","description":"The top GO terms cover development across multiple organs (kidney, heart, nervous system) and several signaling pathways (ROBO, SHH, T cell receptor signaling), plus processes like angiogenesis and apoptosis. This suggests a cluster of proteins involved in broad developmental signaling across tissues, rather than a single pathway.","confidence":"Medium","size":20,"edges":144,"triangles":501,"max_degree":19,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050852","count":9},{"id":"GO:0001822","count":9},{"id":"GO:0035385","count":9},{"id":"GO:0007399","count":9},{"id":"GO:0007224","count":9}]},{"hash":"492577044698907692","title":"Proteoglycan and glycosaminoglycan biosynthesis","description":"The top terms cluster around biosynthetic pathways for proteoglycans and their glycosaminoglycan components\u2014especially heparan sulfate and chondroitin sulfate\u2014with supporting involvement of sulfate assimilation and N-acetylglucosamine metabolism, indicating a cohesive theme of GAG/proteoglycan biosynthesis and sulfation.","confidence":"High","size":20,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000103","count":9},{"id":"GO:0030210","count":8},{"id":"GO:0030206","count":8},{"id":"GO:0009812","count":8},{"id":"GO:0042403","count":8}]},{"hash":"423785630898587884","title":"Developmental Regulation and Neurogenesis","description":"The terms point to broad regulatory roles in development and gene expression, especially transcriptional control (negative regulation of RNA Pol II; positive regulation of miRNA transcription) alongside neural-related development (midbrain, trigeminal ganglion, peripheral nervous system neuron development) and early embryonic processes (primitive streak formation). There are additional hematopoietic differentiation and immune response terms, suggesting a mixed, yet development-centric set of functions. Overall, the cluster reflects transcriptional regulation guiding diverse developmental programs, with a emphasis on neural development, rather than a single specific pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0030901","count":6},{"id":"GO:0090009","count":5},{"id":"GO:0048935","count":5},{"id":"GO:0045648","count":4}]},{"hash":"162211408030746120","title":"Proteoglycan and glycosaminoglycan biosynthesis","description":"Top terms are dominated by chondroitin sulfate and heparan/heparin proteoglycan biosynthesis, plus related carbohydrate metabolism (N-acetylglucosamine, sulfate assimilation). This points to a cohesive theme of glycan assembly and sulfation processes. The presence of additional metabolism terms appears secondary to this glycan-focused core.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030206","count":15},{"id":"GO:0015015","count":15},{"id":"GO:0000103","count":14},{"id":"GO:0030210","count":14},{"id":"GO:0009812","count":14}]},{"hash":"1807005843742623012","title":"Neural and connective tissue development","description":"Top terms link neural development (paranodal junctions, neuron migration, limbic system) with extracellular matrix and adhesion (collagen fibril organization, tendon development, integrin biosynthesis). This points to neural-tissue development allied to ECM remodeling and cell adhesion, supporting a label like \u201cNeural and connective tissue development.\u201d","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070389","count":3},{"id":"GO:0030913","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0014028","count":2},{"id":"GO:0001764","count":2}]},{"hash":"333365001237457275","title":"Neurotransmitter Synthesis and Membrane Transport","description":"The top GO terms cluster around transport of small molecules across membranes (glucose, inositol, pantothenate, biotin, sodium ions) and neural signaling components (acetylcholine biosynthesis, GABA signaling) plus behavior-related terms like locomotory behavior and conditioned taste aversion. This suggests a theme of neural transport and signaling rather than a single metabolic pathway, justifying a combined label. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":4},{"id":"GO:0015798","count":3},{"id":"GO:0015887","count":3},{"id":"GO:0008292","count":3},{"id":"GO:0071436","count":3}]},{"hash":"402392314194095507","title":"Larval chitin-based cuticle development","description":"Based on the single GO term GO:0008363, this cluster is most consistent with proteins involved in larval cuticle formation and chitin-based exoskeleton development. The network shows a dense, highly interconnected group, which is characteristic of a coordinated module likely dedicated to cuticle biosynthesis or assembly, even though only one term is highlighted here.","confidence":"Medium","size":20,"edges":145,"triangles":617,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2}]},{"hash":"1218877480551440407","title":"Potassium Transport and Membrane Potential Regulation in Sensory/Cardiac Tissues","description":"The top GO terms cluster around potassium ion transport/homeostasis and membrane potential regulation, including cardiac atrial repolarization and mechanosensory detection, which together point to ion handling and electrical excitability as the core theme. While there are a few unrelated terms (e.g., lipopolysaccharide response), the dominant signal is potassium transport and membrane potential control across sensory and cardiac contexts.","confidence":"High","size":20,"edges":7,"triangles":1,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0071805","count":8},{"id":"GO:0050976","count":7},{"id":"GO:0098914","count":7}]},{"hash":"988494398385831326","title":"Rac/Ras GTPase signaling and actin dynamics","description":"The top GO terms point to small GTPase\u2013mediated signaling (Rac, Ras), actin filament polymerization and assembly (filopodia, podosomes), and regulation of cell spreading and polarity. This indicates a cohesive function in actin cytoskeleton remodeling driven by Rac/Ras pathways.","confidence":"High","size":20,"edges":32,"triangles":5,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007264","count":11},{"id":"GO:0046847","count":11},{"id":"GO:1900026","count":11},{"id":"GO:0046580","count":10},{"id":"GO:0043552","count":10}]},{"hash":"1646965697896661316","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":3},{"id":"GO:0015074","count":1},{"id":"GO:0032147","count":1},{"id":"GO:0006357","count":1},{"id":"GO:0051123","count":1}]},{"hash":"390709618305116105","title":"Fatty acid biosynthesis and long-chain metabolism","description":"This cluster is dominated by GO terms for fatty acid biosynthesis and metabolism across multiple chain lengths (long-, very long-, and medium-chain) and cellular import of fatty acids, indicating a cohesive lipid metabolic function. While a couple of terms touch on related pathways (nonribosomal peptide biosynthesis activation, and certain catabolic processes like malonate and phenylacetate degradation), the strongest signal is synthesis and metabolism of fatty acids, including transport into the cell, suggesting a cluster centered on fatty acid metabolism and lipid biosynthesis.","confidence":"High","size":20,"edges":135,"triangles":452,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1902987","count":11},{"id":"GO:0006633","count":11},{"id":"GO:0043041","count":10},{"id":"GO:0019654","count":10},{"id":"GO:0090410","count":10}]},{"hash":"2140976645971925400","title":"Embryonic Development and Organ Morphogenesis","description":"The Top Terms point to broad embryogenesis and organ formation processes, including endocrine system development, placental and pancreatic cell differentiation, cartilage morphogenesis, and heart-related EMT. This suggests the cluster clusters proteins involved in early development and tissue morphogenesis across various organs, especially placenta, pancreas, and craniofacial structures.","confidence":"High","size":20,"edges":22,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":17},{"id":"GO:0060806","count":17},{"id":"GO:0003323","count":17},{"id":"GO:0060536","count":17},{"id":"GO:0003198","count":17}]},{"hash":"1452419431364312157","title":"Photoreceptor signaling and differentiation","description":"The GO terms center on visual perception and photoreceptor cell differentiation, with supporting signaling and exocytotic processes that align with retinal photoreceptor function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0009786","count":1},{"id":"GO:0006470","count":1},{"id":"GO:0043407","count":1}]},{"hash":"1767449779543301874","title":"Nervous system development and axonogenesis","description":"The top GO terms point strongly to neuronal development and axon-related signaling (axonogenesis, nervous system development, nerve impulse transmission, Roundabout and Hedgehog signaling, and sodium channel clustering), suggesting a cohesive cluster of proteins involved in neuron formation and function. Some terms like T cell receptor signaling and kidney development may reflect incidental annotations rather than core function.","confidence":"High","size":20,"edges":77,"triangles":43,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0050772","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0001822","count":4},{"id":"GO:0045162","count":4}]},{"hash":"1668826892036239075","title":"Intracellular metal ion homeostasis and transport","description":"The top GO terms cluster around maintenance and movement of metal ions (magnesium, zinc, iron, cobalt, cadmium) inside cells and across membranes, including zinc transport and detoxification, indicating a coherent role in metal ion homeostasis and transport rather than a single metal.","confidence":"High","size":20,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0010961","count":3},{"id":"GO:0071584","count":2},{"id":"GO:1903874","count":2},{"id":"GO:0098849","count":2},{"id":"GO:0006882","count":2}]},{"hash":"1742387357619029582","title":"Unknown","description":"The GO terms cover a wide range of developmental processes (placenta, cartilage, pancreatic cell development) and immune-related activities (antigen processing and presentation, defense response to bacterium), with no clear single biological theme tying them together.","confidence":"","size":20,"edges":65,"triangles":88,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006869","count":2},{"id":"GO:0008363","count":1},{"id":"GO:0048147","count":1},{"id":"GO:0042590","count":1},{"id":"GO:1900426","count":1}]},{"hash":"1699424741465404680","title":"Fatty acid metabolism and transport","description":"The top terms are dominated by fatty acid metabolic processes across chain lengths (long-, very long-, and medium-chain), plus fatty acid import and acyl-CoA related steps, indicating a cohesive cluster focused on fatty acid utilization and cellular uptake. A few outlier terms (e.g., phenylpropanoid metabolism) are present but do not override the central lipid theme.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1902987","count":16},{"id":"GO:0043041","count":13},{"id":"GO:0019654","count":13},{"id":"GO:0090410","count":13},{"id":"GO:0001676","count":13}]},{"hash":"1650663193440845510","title":"Muscle structure, cardiac development, and cytoskeletal signaling","description":"Top GO terms such as sarcomere organization and heart development point to muscle tissue architecture and cardiac differentiation, while Rho signaling regulation and cell adhesion suggest cytoskeletal dynamics and cell\u2013matrix interactions that underlie muscle and heart formation. Some terms (endosomal transport, spermatid development, dendritic spine regulation) imply broader cytoskeletal or trafficking roles, but the dominant pattern centers on muscle structure and cardiac development, making this label representative. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0030682","count":2},{"id":"GO:0016197","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0010765","count":2}]},{"hash":"361062887737708420","title":"Neuronal Transport and Axon Maintenance","description":"The cluster\u2019s top GO terms cluster around transport activities (general transport and mitochondrial transport) and neuronal/axon-related processes (neuron projection maintenance and efferent axon development in the posterior lateral line nerve). This suggests a common function in neurite transport and axon maintenance rather than a broad, disparate set of roles. A few sporadic terms (sporulation remodeling, lipid regulation) appear infrequent and likely noise. Overall, the data point to a cohesive theme of neuronal transport and axon maintenance.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006810","count":2},{"id":"GO:0030682","count":2},{"id":"GO:1990535","count":2},{"id":"GO:0006839","count":2},{"id":"GO:0048929","count":2}]},{"hash":"505879201502010167","title":"P450-driven prostaglandin and lipid biosynthesis","description":"This cluster\u2019s top terms cluster around prostaglandin biosynthesis, omega-hydroxylase and epoxygenase P450 pathways, calcitriol biosynthesis, triglyceride metabolism, and reproductive development (sex differentiation, prostate gland growth, parturition). Together these point to cytochrome P450\u2013mediated lipid-derived signaling and hormone biosynthesis as the shared function, with some noise from unrelated annotations such as vancomycin biosynthesis. ","confidence":"Medium","size":20,"edges":186,"triangles":1071,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":18},{"id":"GO:0006641","count":11},{"id":"GO:0060736","count":10},{"id":"GO:0033072","count":10},{"id":"GO:0036378","count":10}]},{"hash":"2132395251697752880","title":"DNA repair and genome maintenance","description":"This cluster is driven by strong enrichment for DNA recombination, DNA transposition, and base-excision repair, with apoptosis also represented, indicating a DNA damage response and genome integrity maintenance theme. Other terms like mRNA stability regulation and redox homeostasis are present but secondary, so the core function centers on DNA repair and genome maintenance.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":11},{"id":"GO:0006313","count":9},{"id":"GO:0045454","count":6},{"id":"GO:0090502","count":6},{"id":"GO:0043488","count":6}]},{"hash":"253096461144377132","title":"Membrane Transporters for Ions and Metabolites","description":"The top GO terms cluster around transmembrane transport of ions (sodium, potassium), nitrite/nitrate uptake, sugar transport (galactose, arabinose, fucose), vitamin transport, and neurotransmitter loading into synaptic vesicles, indicating a cohesive set of membrane transporter proteins with diverse substrates.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0015707","count":5},{"id":"GO:0042128","count":5},{"id":"GO:0006004","count":5}]},{"hash":"566889641825587977","title":"Viral integration and retrotransposition","description":"The top GO terms cluster around viral entry, proviral latency, DNA integration, and transposition (DNA transposition and retrotransposition), indicating processes tied to viral life cycles and mobile genetic elements. This combination best reflects a theme of proviral integration and transposon activity.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0046718","count":8},{"id":"GO:0075732","count":8},{"id":"GO:0075713","count":8},{"id":"GO:0015074","count":8},{"id":"GO:0039651","count":8}]},{"hash":"1778268879483475631","title":"Vascular development and remodeling","description":"This cluster shows a coherent theme around blood vessel biology: blood coagulation, smooth muscle cell migration, elastin catabolic processes, leukocyte tethering/rolling, and regulation of cell proliferation\u2014all processes involved in vascular development and vessel wall remodeling. The presence of midbrain development is less consistent with this theme and some terms are obsolete, suggesting some annotation noise, but the core terms strongly point to vascular/immune remodeling. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0007596","count":6},{"id":"GO:0014909","count":6},{"id":"GO:1903238","count":5}]},{"hash":"2029447988165430283","title":"Viral Integration and Proviral Latency","description":"These terms collectively point to viral genome integration into host DNA and maintenance of proviral latency, along with related transposon activities (DNA transposition, retrotransposition) and core viral life-cycle steps (entry into host cells and nucleus, virion assembly). While some terms reflect general host mRNA processing, the dominant signal is viral integration/latency and transposition, defining the cluster\u2019s theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0075713","count":6},{"id":"GO:0015074","count":6},{"id":"GO:0039651","count":6},{"id":"GO:0046718","count":5},{"id":"GO:0075732","count":5}]},{"hash":"542707883699579122","title":"Melanosome biogenesis and pigment granule transport","description":"The GO terms point strongly to pigment-related organelles and trafficking, including melanocyte differentiation, eye pigment granule organization, endosome-to-lysosome transport, and secretion of lysosomal enzymes, all of which align with melanosome biogenesis and pigment granule movement. Some vesicle trafficking terms (synaptic vesicle fusion/transport) may reflect shared machinery but do not override the pigment-focused theme. This cluster most plausibly represents melanosome formation and pigment granule trafficking in pigment cells.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030318","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0033299","count":1},{"id":"GO:0048490","count":1},{"id":"GO:0006886","count":1}]},{"hash":"782043816192752857","title":"Embryonic Development and Morphogenesis","description":"The GO terms cluster around broad embryonic development and tissue formation, including endocrine system development, placental and pancreatic cell development, cartilage morphogenesis, EMT in heart development, left-right patterning, trophoblast differentiation, biomineral tissue formation, and remodeling processes like collagen catabolism and coagulation\u2014together signaling a theme of organogenesis and tissue morphogenesis during development.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0003198","count":5}]},{"hash":"1003096748608858532","title":"Lung morphogenesis and ECM remodeling","description":"The top GO terms cluster around lung development and morphogenesis, including dichotomous subdivision of terminal units involved in lung branching and epithelial tube branching in lung morphogenesis, along with basement membrane disassembly and collagen catabolic processes. This suggests proteins involved in shaping lung structure via extracellular matrix remodeling. Some terms (e.g., bone resorption, T cell cytotoxicity, thyroid hormone response) reflect broader ECM turnover or signaling that can accompany development, but the strongest signal is lung morphogenesis with ECM remodeling. ","confidence":"Medium","size":19,"edges":103,"triangles":355,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0060448","count":13},{"id":"GO:0010815","count":13},{"id":"GO:0034769","count":13},{"id":"GO:2000179","count":13},{"id":"GO:0045453","count":13}]},{"hash":"580214170195289243","title":"RNA processing and transcriptional regulation","description":"This cluster is dominated by GO terms related to RNA capping and RNA methylation, plus regulation of transcription by RNA polymerase II and transcriptional regulation, suggesting a cohesive function in RNA processing and control of gene expression. Some terms about bacterial flagellum, T3SS, and organellar processes appear as outliers, indicating annotation noise or broader cellular roles, but the core signal centers on RNA processing and transcriptional regulation.","confidence":"Medium","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":3},{"id":"GO:0036265","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0090090","count":2},{"id":"GO:0006355","count":1}]},{"hash":"500556402650899248","title":"Larval chitin-based cuticle development","description":"The cluster is defined by GO:0008363 with 19 proteins, all pointing to larval chitin-containing cuticle formation in insects, suggesting a cohesive module for cuticle biosynthesis and formation during larval development.","confidence":"High","size":19,"edges":156,"triangles":773,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":19}]},{"hash":"2001212572169660073","title":"Transmembrane Transport of Metabolites","description":"Based on the GO terms, the cluster centers on membrane-associated transport of small molecules and ions (inositol, pantothenate, biotin, glucose) and related biosynthesis processes, implying proteins that mediate uptake/export across membranes rather than a single biological process.","confidence":"Medium","size":19,"edges":65,"triangles":73,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0015798","count":1},{"id":"GO:0015887","count":1},{"id":"GO:0008292","count":1},{"id":"GO:0071436","count":1}]},{"hash":"1760507725421582871","title":"Neural development and synapse assembly","description":"This cluster is dominated by terms tied to nervous system development, synapse assembly, and nerve impulse transmission, including protein localization to the juxtaparanode region of axons, pointing to neuronal development and synaptic organization as the core theme. Immune and bone-related terms are present but appear peripheral to the main neural signal.","confidence":"High","size":19,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":4},{"id":"GO:0035902","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0051965","count":3}]},{"hash":"143285539033212666","title":"Retroviral integration and latency","description":"These terms point to steps in a retroviral life cycle: entry into the host cell, transport into the nucleus, reverse transcription (RNA-templated DNA synthesis), DNA integration and establishment of proviral latency, and associated host responses such as interferon signaling and apoptosis modulation. The presence of DNA recombination/replication terms supports genome integration and maintenance of proviral DNA.","confidence":"High","size":19,"edges":37,"triangles":5,"max_degree":9,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0090502","count":4},{"id":"GO:0046718","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0043137","count":3},{"id":"GO:0075713","count":3}]},{"hash":"1653698311539869270","title":"Neurodevelopmental transcription regulation","description":"This cluster centers on transcriptional control (negative regulation of transcription by RNA polymerase II, DNA-templated transcription) alongside neural development terms (cerebellar granule cell precursor proliferation, radial glia\u2013guided migration of Purkinje cells) and related signaling/cell-cycle processes, suggesting proteins involved in transcriptional regulation during cerebellar neurodevelopment.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0016032","count":4},{"id":"GO:0070933","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0006915","count":3}]},{"hash":"2029277975682146650","title":"Embryogenesis and Xenobiotic/Stress Response","description":"GO terms point to embryonic development, especially primitive erythrocyte differentiation, alongside widespread responses to xenobiotics and environmental stress (xenobiotic stimulus, ethanol, LPS, corticosterone, fungicide). This pattern suggests a cluster centered on developmental processes that also participate in environmental sensing and detoxification, hence 'Embryogenesis and Xenobiotic/Stress Response' with Medium confidence.","confidence":"Medium","size":19,"edges":93,"triangles":189,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":9},{"id":"GO:0006550","count":9},{"id":"GO:0055114","count":9},{"id":"GO:0042493","count":9},{"id":"GO:0045471","count":9}]},{"hash":"675238357052642994","title":"Biosynthesis and RNA Modification Cluster","description":"Most of the top GO terms point to biosynthetic processes (chlorophyll, sterol, ubiquinone, biotin, polyamine biosynthesis) and a pair related to RNA processing (mRNA capping and guanine-N7 methylation). This suggests a broad metabolic/biosynthetic theme with some RNA modification activity rather than a single, tightly defined pathway. Some terms like nodulation and tellurium ion response are less connected, but may reflect broader plant-associated metabolism or stress responses. Confidence reflects how well this single label captures the cluster\u2019s diversity.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":8},{"id":"GO:0036265","count":8},{"id":"GO:0006596","count":7},{"id":"GO:0006744","count":6},{"id":"GO:0090398","count":6}]},{"hash":"1448114500031193055","title":"Regulation of Signaling and Secretion","description":"The top GO terms are all regulatory in nature and span multiple biological systems, including immune (negative regulation of chemokine production), nervous (regulation of sensory perception of pain, response to morphine, regulation of membrane potential), endocrine (regulation of insulin secretion, negative regulation of renin secretion), and signaling pathways (positive regulation of Rho signaling, IP3 biosynthesis). This suggests the cluster is composed of proteins that modulate various signaling or secretion processes rather than a single, specific pathway, hence a label focused on broad regulatory signaling/secretion.","confidence":"Medium","size":19,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090198","count":17},{"id":"GO:0051930","count":17},{"id":"GO:0043278","count":17},{"id":"GO:0033861","count":17},{"id":"GO:1900134","count":17}]},{"hash":"1656615524630348273","title":"Neural and cardiovascular lineage differentiation","description":"The top GO terms point to differentiation of neural and neuroendocrine lineages (e.g., carotid body glomus cell differentiation, lung neuroendocrine cell differentiation, oculomotor nerve development, subpallium neuron differentiation timing) and to heart-related processes (regulation of heart rate by chemical signals, heart induction pathways). This suggests a cohesive theme of development across neural, neuroendocrine, and cardiovascular lineages, supporting a label focused on neural and cardiovascular differentiation.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0061103","count":15},{"id":"GO:0003062","count":15},{"id":"GO:2000820","count":15},{"id":"GO:0060165","count":15},{"id":"GO:0072277","count":15}]},{"hash":"2163056675260907072","title":"Neurodevelopment with innate immune signaling","description":"This cluster mixes neural development terms (axonogenesis, corpus callosum development, positive regulation of synapse assembly) with innate immune responses (innate immune response, lipopolysaccharide response, dsRNA response, defense against Gram-positive bacteria) and pain-related behavior, suggesting proteins involved in neural development that also participate in immune signaling or nociceptive pathways. Confidence: Medium","confidence":"","size":19,"edges":18,"triangles":0,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0071222","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0043330","count":5},{"id":"GO:0007409","count":5}]},{"hash":"259634236161974501","title":"Mitochondrial Energy Metabolism and Redox Homeostasis","description":"The cluster is dominated by GO terms for mitochondrial respiration (NADH to ubiquinone), lipoate-related metabolism, and redox processes, indicating a core function in energy production and redox balance within mitochondria. Some germline development terms appear, but the central theme remains mitochondrial metabolism and redox regulation.","confidence":"High","size":19,"edges":67,"triangles":73,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045454","count":6},{"id":"GO:0043046","count":6},{"id":"GO:0006120","count":6},{"id":"GO:0042391","count":6},{"id":"GO:0051068","count":6}]},{"hash":"1598156698232335295","title":"Transcriptional Regulation & RNA Processing","description":"The top GO terms cluster around gene expression control: DNA-templated transcription, transcriptional regulation by RNA Pol II, mRNA splicing, and RNA guanine-N7 methylation, plus epigenetic regulation of histone methylation. Although there are a few developmental terms, the dominant signal points to regulation of transcription and RNA processing, with epigenetic connections, making this a coherent label.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0007420","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0000398","count":2}]},{"hash":"1100836162762372199","title":"Innate immune response and inflammation","description":"This cluster centers on innate immune defense and inflammatory signaling, with terms for proteolysis, regulation of complement activation, neutrophil extravasation, and defense against bacteria, plus ERK signaling. Kidney and heart development terms appear but are less central, suggesting the core theme is immune response and inflammation rather than organ development.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:0010765","count":3},{"id":"GO:0045959","count":2},{"id":"GO:0001869","count":2},{"id":"GO:2000391","count":2}]},{"hash":"66447502754322584","title":"Neuronal ion transport and synaptic plasticity","description":"Top terms group around transmembrane ion transport (sodium, potassium, calcium, manganese) and general membrane transport, with a theme of synaptic regulation (long-term synaptic depression) and neuronal signaling (startle response, cell communication). This combination supports a label for a cluster of proteins involved in neuronal ion handling and synaptic plasticity.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":3},{"id":"GO:0098703","count":3},{"id":"GO:0006828","count":3},{"id":"GO:0055085","count":2},{"id":"GO:0001964","count":2}]},{"hash":"102289976007580696","title":"Photorespiration and associated carbon metabolism","description":"The top GO terms point to photorespiration and related carbon/organic acid pathways (glycolate/glyoxylate metabolism, glycolate catabolic process, oxidative photosynthetic carbon pathway, lactate oxidation, mandelate metabolism) along with interconnected amino acid and primary metabolite synthesis (glutamate biosynthesis, ammonia assimilation, isoprenoid biosynthesis). This suggests a cohesive cluster of proteins functioning in chloroplast-centric carbon flux tied to photorespiration and broader metabolic processing of organic acids and nitrogen. Confidence: Medium","confidence":"","size":19,"edges":12,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009854","count":4},{"id":"GO:0080114","count":4},{"id":"GO:0019516","count":4},{"id":"GO:0001561","count":4},{"id":"GO:0046296","count":4}]},{"hash":"1573589778737420074","title":"Fatty Acid Metabolism & Transport","description":"The top GO terms cluster around long-chain, very long-chain, and medium-chain fatty acid metabolism and cellular import, indicating a cohesive lipid metabolism and transport function.","confidence":"High","size":19,"edges":60,"triangles":61,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:1902987","count":14},{"id":"GO:0043041","count":11},{"id":"GO:0019654","count":11},{"id":"GO:0090410","count":11},{"id":"GO:0001676","count":11}]},{"hash":"1719512765864948207","title":"Unknown","description":"Top GO terms span DNA transposition, immune defense and complement activation, proteolysis/fibrinolysis, transcription regulation, and host\u2013pathogen interaction, with no clear unifying function across all proteins. This lack of a cohesive theme makes a specific, concise label inappropriate, so Unknown with None confidence.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006313","count":4},{"id":"GO:0045766","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0000122","count":3}]},{"hash":"2085842238825691141","title":"Neural development and synaptic signaling","description":"The top GO terms cluster around nervous system development, axon guidance, synapse regulation, and ionotropic glutamate receptor signaling, with supportive terms on calcium homeostasis and neural remodeling, suggesting a neural development and synaptic function theme despite a few non-neural terms.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060670","count":5},{"id":"GO:0051563","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0010951","count":4},{"id":"GO:0048669","count":4}]},{"hash":"574499997044753419","title":"Synaptic Vesicle and Endosomal Transport","description":"The GO terms cluster around vesicle trafficking: anterograde synaptic vesicle transport, neurotransmitter receptor transport via endosomes to lysosomes, retrograde Golgi-to-ER transport, and synaptic vesicle membrane organization, plus endosome-to-melanosome transport and protein storage vacuole organization. These converge on intracellular transport and membrane trafficking in neurons. A couple of terms refer to ribosomal large-subunit assembly, which are less clearly linked to trafficking; overall the dominant signal is vesicle/endosome transport, hence the chosen label.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902626","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0048490","count":2},{"id":"GO:0098943","count":2},{"id":"GO:1900126","count":2}]},{"hash":"3953657118893405","title":"Unknown","description":"The top GO terms span diverse functions (protein O-linked glycosylation via mannose, transcription termination, and various chromatin-related modifications), with many entries marked obsolete. The lack of a unifying, current functional theme and the prevalence of obsolete annotations suggest this cluster does not reflect a coherent biological process, so a single interpretable label cannot be assigned.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035269","count":2},{"id":"GO:0046329","count":1},{"id":"GO:0060049","count":1},{"id":"GO:0006363","count":1},{"id":"GO:0016584","count":1}]},{"hash":"1555849814602414411","title":"Glycosaminoglycan/Proteoglycan Biosynthesis","description":"The cluster is dominated by GO terms related to heparan sulfate and chondroitin sulfate biosynthesis, N-acetylglucosamine metabolism, and sulfate assimilation, pointing to a cohesive theme of glycosaminoglycan production and related carbohydrate modification (with some broader metabolic terms appearing as ancillary signals).","confidence":"High","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000103","count":10},{"id":"GO:0030210","count":10},{"id":"GO:0030206","count":10},{"id":"GO:0009812","count":10},{"id":"GO:0042403","count":10}]},{"hash":"2284780081397100519","title":"Lipid Metabolism and Cholesterol Transport","description":"The proteins in this cluster are enriched for triglyceride and lipid handling terms (catabolic and biosynthetic processes, lipid digestion), as well as remodeling of HDL and VLDL particles and cholesterol homeostasis, including intestinal cholesterol absorption. Together, these terms point to a core theme of lipid metabolism and lipoprotein-mediated cholesterol transport, with one outlier term related to chemokine production not altering the overall function.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":5},{"id":"GO:0044241","count":3},{"id":"GO:0034375","count":3},{"id":"GO:0043691","count":3},{"id":"GO:0034372","count":3}]},{"hash":"590024150610966038","title":"Neural development and synaptic signaling","description":"The cluster features strong representation of nervous system development, axon guidance, ionotropic glutamate receptor signaling, and regulation of synapse structure or activity, plus calcium homeostasis in the endoplasmic reticulum. Together, these terms point to functions in neuronal development and synaptic transmission/organization, suggesting the proteins act in neural connectivity and signaling. Some terms on branching morphogenesis appear more peripheral but do not override the central neural theme.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051563","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0060670","count":5},{"id":"GO:0010951","count":5},{"id":"GO:0048669","count":5}]},{"hash":"2009188328481169430","title":"Bacterial transposons and cell wall synthesis","description":"Top GO terms emphasize DNA transposition and DNA integration, indicating mobile genetic elements such as transposases. The inclusion of peptidoglycan biosynthesis and D-alanine biosynthesis points to bacterial cell wall construction. While a couple of terms hint at host interactions, the dominant signals align with transposon-related functions and bacterial cell wall assembly.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":5},{"id":"GO:0015074","count":2},{"id":"GO:0090305","count":2},{"id":"GO:0071555","count":1},{"id":"GO:0009252","count":1}]},{"hash":"217604853858652790","title":"Neural Development and Social Behavior","description":"The top GO terms point to neural development (neuron projection development) and social behavior, suggesting proteins involved in nervous system development and related behavioral functions. Additional terms referencing lens/skeletal development hint at broader developmental roles. Some outliers (chromatin regulation and DNA transposition) may reflect general regulatory activities rather than a single pathway. Overall, the cluster appears to be centered on neural development with social behavioral associations.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":3},{"id":"GO:0006349","count":2},{"id":"GO:0043966","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0031175","count":2}]},{"hash":"1267100857157209044","title":"Transmembrane transport of ions and metabolites","description":"The top GO terms converge on transport across membranes: sialic acid, amino acids, calcium, nitrite/nitrate, sodium, vitamins, and neurotransmitter loading into synaptic vesicles, indicating a cohesive set of membrane transport proteins handling movement of ions and small molecules rather than a single metabolic pathway.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":3},{"id":"GO:0032973","count":3},{"id":"GO:1990034","count":3},{"id":"GO:0015707","count":2},{"id":"GO:0042128","count":2}]},{"hash":"1406552623185243910","title":"Embryonic neural and epidermal development signaling","description":"The top GO terms cluster around developmental processes in neural/eye tissues (brain development, retina development, neural tube closure, embryonic organ development) and skin (skin development). TORC1 signaling and glucose-mediated signaling suggest growth and metabolic regulation during development, together pointing to coordinated signaling guiding embryonic tissue differentiation and growth in neural/retinal and epidermal lineages.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038202","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0060041","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0001843","count":4}]},{"hash":"743560880275838809","title":"Embryonic development and placental morphogenesis","description":"The top GO terms are dominated by developmental processes such as endocrine system development, placenta and pancreatic cell development, cartilage morphogenesis, and EMT in heart cushion formation, along with left-right pattern formation and trophoblast differentiation. Together these terms point to a coherent theme of embryogenesis and placental/organ morphogenesis rather than a single specific pathway, so the label reflects the cluster\u2019s broad developmental nature.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":16},{"id":"GO:0060806","count":16},{"id":"GO:0003323","count":16},{"id":"GO:0060536","count":16},{"id":"GO:0003198","count":16}]},{"hash":"1486059690228029203","title":"Viral DNA integration and latency","description":"This cluster centers on steps of the viral life cycle and proviral state, highlighted by terms for DNA integration and establishment of integrated proviral latency, as well as viral entry/penetration into the host nucleus. The presence of host RNA processing/manipulation terms (e.g., mRNA splicing, no-go decay) likely reflects host machinery involvement during infection, consistent with virus\u2013host interaction themes. Overall, the proteins appear tied to viral genome integration and latency in the host cell.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0090502","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0032790","count":2}]},{"hash":"1533426991497955013","title":"DNA transposition and integration proteins","description":"The cluster is dominated by GO terms for DNA integration and DNA transposition, indicating a common function related to DNA mobility within genomes. While a few terms touch on vesicle trafficking and immune regulation, these are much less represented and do not form a cohesive alternative theme. With no reported edges, the strongest signal is DNA mobility, supporting this label.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0090305","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0043547","count":2},{"id":"GO:2000553","count":1}]},{"hash":"828556377421364126","title":"Dopaminergic Signaling and Visual Processing","description":"This label captures the strongest signals in the set: dopaminergic synaptic transmission, visual perception and learning, and ERK-mediated phosphorylation, suggesting a neural/sensory signaling module. Peripheral terms like heart development and macrophage chemotaxis are present but do not override the core neural theme.","confidence":"Medium","size":18,"edges":120,"triangles":422,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":10},{"id":"GO:0048148","count":10},{"id":"GO:0001963","count":10},{"id":"GO:0007507","count":10},{"id":"GO:0071380","count":10}]},{"hash":"1464746559188842845","title":"Microtubule Spindle Assembly and Nuclear Migration","description":"This cluster is characterized by GO terms tied to microtubule cytoskeleton dynamics and mitotic spindle functions: spindle assembly, centrosome separation, establishment/maintenance of microtubule polarity, and nuclear migration along microtubules. Additional terms such as chloroplast movement and karyogamy reflect microtubule-driven intracellular transport and fusion processes; even terms like regulation of integrin activation can connect to cytoskeletal remodeling. The common thread is microtubule-dependent organization and movement central to cell division and intracellular trafficking.","confidence":"High","size":18,"edges":47,"triangles":52,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0009904","count":8},{"id":"GO:0090307","count":8},{"id":"GO:0030951","count":8},{"id":"GO:0033624","count":8},{"id":"GO:0030473","count":8}]},{"hash":"461492363615358057","title":"Innate Immune Signaling and Antigen Processing","description":"The terms point to innate immune activation and phagocytosis, plus antigen processing with MHC I; supported by ER protein folding and unfolded protein response, indicating protein handling in immune-related contexts. The cluster thus seems to reflect immune signaling and antigen processing with protein homeostasis.","confidence":"Medium","size":18,"edges":76,"triangles":200,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:1901224","count":1},{"id":"GO:0010204","count":1},{"id":"GO:0006457","count":1},{"id":"GO:1900026","count":1},{"id":"GO:0030968","count":1}]},{"hash":"465399444534079932","title":"Unknown","description":"The GO terms span neural development (axonal fasciculation, corpus callosum development, synapse assembly, acetylcholine metabolism) but also include bone development and ovarian follicle growth, with no single coherent process tying all terms together. Because the terms indicate multiple tissue contexts and broad functions rather than a unified pathway, there is no clear theme to label the cluster beyond Unknown.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071169","count":3},{"id":"GO:0048681","count":3},{"id":"GO:0022038","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0051965","count":3}]},{"hash":"722519039720588934","title":"Embryonic development and organ morphogenesis","description":"This cluster is dominated by GO terms related to embryonic development across multiple tissues (neural crest migration, brain and cranial skeleton development, pancreas development, ureteric branching) and processes of gene regulation (transcription and chromatin remodeling), suggesting it represents regulatory programs driving embryogenesis and organ morphogenesis.","confidence":"High","size":18,"edges":13,"triangles":2,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0048557","count":8},{"id":"GO:0001755","count":8},{"id":"GO:0031018","count":8},{"id":"GO:0090190","count":8}]},{"hash":"716195964407088630","title":"Embryonic Development and Cell Differentiation","description":"The top GO terms cluster around development and differentiation across tissues (multicellular organism development, epidermal cell fate specification, glial differentiation/proliferation, placental/parathyroid development, and plasmatocyte differentiation). Despite tissue diversity, the common theme is embryonic development and cell fate specification, indicating these proteins are linked to developmental regulation rather than a single pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060017","count":2},{"id":"GO:0060670","count":2},{"id":"GO:0030682","count":1},{"id":"GO:0045687","count":1},{"id":"GO:0006355","count":1}]},{"hash":"614054458275602850","title":"Chromatin Regulation and Innate Immunity","description":"The cluster\u2019s top terms point to chromatin dynamics and transcription control (chromatin organization, DNA replication-dependent chromatin assembly, and regulation of transcription by RNA polymerase II) along with innate immune signaling (innate immune response, cellular response to exogenous dsRNA, and cellular response to type I interferon). Some terms like blastocyst development and digestion are outliers, suggesting multifunctional proteins annotate to diverse processes, but the core linkage appears to be chromatin regulation coupled with antiviral signaling.","confidence":"Medium","size":18,"edges":39,"triangles":30,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0001824","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0007586","count":2},{"id":"GO:0045087","count":1},{"id":"GO:0006336","count":1}]},{"hash":"1777704437818395982","title":"Diverse Biosynthesis and Signaling Pathways","description":"The top GO terms indicate a focus on multiple biosynthetic processes (heme biosynthetic, protoporphyrinogen IX biosynthesis, biotin biosynthesis, sphingomyelin biosynthesis), along with metabolic activities (oxaloacetate metabolism, fatty acid transport) and signaling routes (Notch pathway, cellular response to insulin). This combination suggests a cluster enriched for varied biosynthetic and signaling roles rather than a single, cohesive function.","confidence":"Medium","size":18,"edges":76,"triangles":192,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006107","count":6},{"id":"GO:0006686","count":5},{"id":"GO:0032869","count":5},{"id":"GO:0007219","count":5},{"id":"GO:0015908","count":5}]},{"hash":"48197568346520158","title":"GPCR-cAMP-Calcium Brain-Endocrine Signaling","description":"This cluster is dominated by GO terms for GPCR-activated adenylate cyclase signaling and cytosolic calcium regulation, plus related endocrine processes (growth hormone secretion, blood pressure regulation) and brain development (cerebral cortex regionalization), suggesting a coherent theme of GPCR-cAMP-Ca2+ signaling in neural and endocrine contexts.","confidence":"High","size":18,"edges":12,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":12},{"id":"GO:0010579","count":12},{"id":"GO:0045777","count":12},{"id":"GO:0007190","count":10},{"id":"GO:0043031","count":8}]},{"hash":"1578490492509357957","title":"Unknown","description":"The top GO terms span endothelial proliferation, neuronal development/apoptotic regulation, cytokine signaling (IL-4), salt stress response, protein autophosphorylation, and even DNA transposition, with some obsolete terms and an odd entry (otolith tethering). This mix points to no single cohesive function or pathway linking all 18 proteins, suggesting annotation noise or very diverse functions.  ","confidence":"","size":18,"edges":12,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":3},{"id":"GO:0043524","count":2},{"id":"GO:0071353","count":2},{"id":"GO:0035889","count":2},{"id":"GO:0046777","count":2}]},{"hash":"1656123068732201755","title":"Light-regulated circadian and synaptic signaling","description":"The cluster centers on neural signaling modulated by light and circadian cues: phototransduction and far-red signaling relate to circadian rhythm regulation, while GABAergic and glutamatergic transmission, along with amygdala development and observational learning, point to CNS neuronal communication and light-influenced behavior. A few terms are peripheral, but the dominant theme is light-driven neural signaling.","confidence":"High","size":18,"edges":17,"triangles":0,"max_degree":17,"top_function":"lysosome organization","top_go_terms":[{"id":"GO:0009585","count":3},{"id":"GO:0010018","count":3},{"id":"GO:0042753","count":3},{"id":"GO:0070444","count":3},{"id":"GO:2001246","count":3}]},{"hash":"984508089986590069","title":"Unknown","description":"The top terms span neural signaling (receptor clustering, memory, amphetamine response) and broad processes like ion transport and development (bone, heart, spermatogenesis) plus signaling cascades, with no single unifying function evident among the proteins. This suggests a diverse or multi-domain cluster rather than a coherent, specific biological theme.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043113","count":4},{"id":"GO:0001975","count":3},{"id":"GO:0007616","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3}]},{"hash":"1762247132163891791","title":"Metabolism and Organelle Organization","description":"Top GO terms point to a blend of metabolic processes (glycogen biosynthesis, fatty acid catabolism, galactose catabolic process, lysine biosynthesis) and organelle-related activities (cell wall organization, endoplasmic reticulum organization), plus translation-related functions (mitochondrial translation, glutaminyl-tRNAGln biosynthesis). This combination suggests proteins involved in general metabolism and maintenance/organization of cellular compartments rather than a single, cohesive pathway. Confidence: Medium","confidence":"","size":18,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":5},{"id":"GO:0032543","count":5},{"id":"GO:0005978","count":4},{"id":"GO:0009062","count":4},{"id":"GO:0019876","count":4}]},{"hash":"1753965214261462217","title":"Embryonic development and tissue morphogenesis","description":"Most of the top GO terms point to embryonic development and tissue morphogenesis (endocrine system development, placenta and mesoderm differentiation, pancreatic endocrine development, cartilage morphogenesis, EMT in endocardial cushion formation, left-right patterning, trophoblast differentiation). A few entries relate to basic mRNA splicing, but overall the cluster centers on developmental differentiation and patterning rather than a single pathway. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0003198","count":6}]},{"hash":"1378073617169397914","title":"Vesicle trafficking and endosomal transport","description":"The top GO terms point to intracellular transport and endosomal routing: regulation of synaptic vesicle exocytosis, endosome-to-lysosome transport, endosome-to-Golgi transport, and Cvt pathway targeting, with additional GTPase activity regulation\u2014all hallmark features of vesicle trafficking pathways. A few terms (mitotic cell cycle, ossification) are less connected and likely noise, but the dominant signal supports vesicle trafficking and endosomal transport as the cluster theme.","confidence":"Medium","size":18,"edges":13,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010796","count":6},{"id":"GO:2000300","count":5},{"id":"GO:0031384","count":5},{"id":"GO:0002551","count":4},{"id":"GO:0034260","count":4}]},{"hash":"1945079244380702794","title":"Reproductive Hormones and Lipid Metabolism","description":"GO terms point to lipid-derived hormone production and reproductive development, including prostaglandin biosynthesis, calcitriol synthesis, and P450-mediated lipid metabolism (omega-hydroxylase, epoxygenase). The presence of triglyceride metabolism and reproductive-related terms (prostate growth, sex differentiation, maternal parturition) reinforces a theme of lipid signaling in reproduction. One term seems unrelated (vancomycin biosynthetic process) and may be annotation noise, but the core pattern is lipid hormone metabolism linked to reproduction.","confidence":"Medium","size":18,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060736","count":18},{"id":"GO:0033072","count":18},{"id":"GO:0036378","count":18},{"id":"GO:0097267","count":18},{"id":"GO:0006641","count":18}]},{"hash":"1107394048859747904","title":"Vertebrate neural development and organogenesis","description":"Because the most represented terms describe vertebrate neural development and patterning (floor plate, somitogenesis, spinal cord motor neuron and interneuron specification, oligodendrocyte fate) along with several organogenesis terms (lung vasculature and bronchiole development). The transcription by RNA polymerase II and circadian regulation terms suggest regulatory control during development. Taken together, the cluster seems to group proteins involved in vertebrate embryonic development with a neural emphasis.","confidence":"Medium","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0035881","count":8},{"id":"GO:0060426","count":8},{"id":"GO:0001756","count":8},{"id":"GO:0033504","count":8}]},{"hash":"1247790940539651848","title":"Integrin-mediated signaling and cell adhesion","description":"This cluster shows strong enrichment for integrin-related processes: integrin-mediated signaling, cell-cell adhesion mediated by integrin, and collagen/fibronectin\u2013linked extracellular matrix (ECM) organization and cell migration (e.g., collagen fibril organization, positive regulation of keratinocyte and thymocyte migration). While a few terms touch on fertilization or platelet regulation, the dominant theme ties to integrin signaling and adhesion to ECM, predicting a role in cell adhesion/migration networks.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":5},{"id":"GO:0007338","count":5},{"id":"GO:0090331","count":5},{"id":"GO:2001113","count":4},{"id":"GO:0032331","count":4}]},{"hash":"402305213022934384","title":"Drosophila Developmental Morphogenesis and Sensory Organs","description":"This cluster centers on insect development and morphogenesis, with GO terms pointing to eye photoreceptor development, imaginal disc\u2013derived genital morphogenesis, genital disc development, proboscis morphogenesis, and nerve development. A few terms like endocytic recycling and DNA integration are more general or noisy annotations, but the dominant theme is insect tissue/organ morphogenesis and sensory structure formation, suggesting a cohesive functional theme despite some heterogeneity.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001137","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0001300","count":2},{"id":"GO:0042462","count":1},{"id":"GO:0048804","count":1}]},{"hash":"1585242802714990920","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008103","count":2},{"id":"GO:1904171","count":1},{"id":"GO:0035372","count":1},{"id":"GO:0040038","count":1},{"id":"GO:0007292","count":1}]},{"hash":"1742342673444870642","title":"Tissue Development and Differentiation","description":"Top GO terms are dominated by developmental processes across tissues (endothelial cell proliferation; multicellular organism development; neuron projection development; skeletal system development; lens fiber cell differentiation). The presence of sarcomere organization further supports a muscle/tissue differentiation angle, suggesting proteins involved in development and maturation across multiple lineages. Some terms like DNA transposition and proteolysis appear ancillary and do not define the core theme. Overall, the cluster most plausibly reflects development and differentiation across tissues.","confidence":"Medium","size":18,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":4},{"id":"GO:0006313","count":4},{"id":"GO:0045214","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0031175","count":2}]},{"hash":"438805270943223026","title":"Retroviral DNA integration and latency","description":"The top GO terms point to steps in a retroviral life cycle: entry into the host cell, penetration into the nucleus, integration of viral DNA into the host genome, and establishment of proviral latency, with supporting terms like DNA recombination and DNA replication. The combination strongly suggests a cluster centered on retroviral genome integration and latency.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0071157","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0043066","count":2},{"id":"GO:0046718","count":2}]},{"hash":"1241763288831856935","title":"Postsynaptic assembly and EPSP regulation","description":"The cluster's GO terms emphasize postsynaptic membrane assembly, gephyrin clustering in the postsynaptic density, and regulation of excitatory postsynaptic potentials (both positive and negative), along with active-zone cytoskeletal organization, pointing to a core role in synapse structure and neurotransmission control; peripheral terms like APP metabolism or xenobiotic response are less central.","confidence":"High","size":18,"edges":115,"triangles":355,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":14},{"id":"GO:0008285","count":12},{"id":"GO:0090394","count":12},{"id":"GO:2000463","count":12},{"id":"GO:0097104","count":12}]},{"hash":"2126116706215294270","title":"Vascular inflammation and ECM remodeling","description":"GO terms center on immune/coagulation responses (complement activation, LPS response, leukocyte recruitment) alongside extracellular matrix remodeling (angiogenesis, smooth muscle cell-matrix adhesion, elastin degradation, biomineral-associated tissue development). This combination suggests a cohesive theme of inflammation-driven vascular remodeling and ECM turnover.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031214","count":6},{"id":"GO:0030194","count":6},{"id":"GO:1902947","count":5},{"id":"GO:1903238","count":5},{"id":"GO:2000097","count":5}]},{"hash":"252365575069870844","title":"Tissue morphogenesis and ECM remodeling","description":"The terms cluster around extracellular matrix organization (collagen fibril organization), proteolysis, integrin-mediated cell adhesion, and developmental processes (multicellular organism development, chondrocyte differentiation, keratinocyte migration, VEGF signaling), indicating coordinated tissue morphogenesis and ECM remodeling during development.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":5},{"id":"GO:0032331","count":4},{"id":"GO:0051549","count":4},{"id":"GO:0030199","count":4},{"id":"GO:0010042","count":4}]},{"hash":"1233748912803502256","title":"Viral entry, integration, and latency","description":"The top GO terms point to stages of viral infection and proviral behavior: entry into host cell, penetration into the host nucleus, DNA integration and proviral latency, plus eventual release and host gene expression manipulation. The combination of \"symbiont\" terms with clear viral processes suggests a cluster centered on viral\u2013host genome interactions and latency.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0039651","count":2}]},{"hash":"785505304538390425","title":"Ubiquitin-Dependent Proteolysis and Immune Response","description":"This cluster is dominated by ubiquitination-related GO terms (protein ubiquitination, polyubiquitination, autoubiquitination, ubiquitin-dependent ERAD), pointing to a core role in targeted protein degradation. Immune-related terms (innate immune response, defense response to virus) appear among the top terms, suggesting links between ubiquitin signaling and antiviral immunity. The absence of edges indicates the grouping is annotation-driven rather than network-connected, and a few broader terms (axonogenesis, mechanical stimulus, anti-apoptotic regulation) are likely ancillary. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0045087","count":3}]},{"hash":"1088876436136679477","title":"Unknown","description":"The GO terms cover coagulation, lipid biosynthesis, immune response, sensory perception, and drug-related responses with no clear single theme tying them together, so a coherent functional label isn\u2019t supported for this cluster.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:0071333","count":2},{"id":"GO:0042730","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0030148","count":2}]},{"hash":"839353132695218665","title":"Symbiosis-linked Host Defense and Signaling","description":"The terms cluster around host defense and innate immune responses, including a specific GO term about symbiont-mediated perturbation of host defenses, plus related immune processes like defense against bacteria and leukocyte recruitment. While there are some signaling/development terms (Wnt signaling, fat cell differentiation), the dominant theme is immune modulation in a host-symbiosis context, justifying a label that highlights host defense and immune signaling in relation to symbiosis.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0003016","count":2},{"id":"GO:0045736","count":2},{"id":"GO:0045444","count":2}]},{"hash":"2186188228700611397","title":"Cellular stress response and protein homeostasis","description":"The cluster\u2019s top GO terms center on stress-related processes (ER stress regulation, apoptotic signaling modulation, response to heat and hydrogen peroxide), chaperone-assisted protein folding, and protein targeting/folding; along with a couple of housekeeping themes like DNA replication and iron-sulfur cluster assembly. Together these suggest a coherent theme of maintaining proteostasis and responding to cellular stress, with some fungal cell wall biosynthesis signals that may reflect organism-specific remodeling under stress. ","confidence":"Medium","size":17,"edges":35,"triangles":39,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":7},{"id":"GO:0000902","count":7},{"id":"GO:0070389","count":6},{"id":"GO:0016226","count":6},{"id":"GO:1902037","count":6}]},{"hash":"554539147481835605","title":"Mitochondrial inner membrane protein import and assembly","description":"The cluster is dominated by GO terms related to mitochondrial targeting, assembly of respiratory chain complexes, and insertion of proteins into the mitochondrial inner membrane, pointing to a cohesive set of mitochondrial biogenesis/maintenance proteins. Other terms about general transport and peroxisome autophagy are present but secondary to the mitochondrial assembly theme.","confidence":"High","size":17,"edges":49,"triangles":62,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006626","count":3},{"id":"GO:0033108","count":2},{"id":"GO:0045039","count":2},{"id":"GO:0072321","count":2},{"id":"GO:0007035","count":1}]},{"hash":"1923601102599499808","title":"Neuronal development and vesicle trafficking","description":"Top GO terms indicate neuronal development and GABAergic transmission, paired with Golgi organization and COPII vesicle budding, suggesting active secretory and trafficking processes. The presence of pseudopodium/podosome assembly regulation points to cytoskeletal remodeling for migration and neurite outgrowth. Some terms like mast cell chemotaxis and keratinization may be peripheral, but the core theme centers on neural development linked to vesicle trafficking and cytoskeletal dynamics.","confidence":"Medium","size":17,"edges":43,"triangles":23,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":13},{"id":"GO:0051932","count":12},{"id":"GO:0007030","count":12},{"id":"GO:0060753","count":12},{"id":"GO:0002551","count":12}]},{"hash":"1760285950198790047","title":"Glycosaminoglycan and proteoglycan biosynthesis","description":"The top GO terms cluster around glycosaminoglycan biosynthesis and proteoglycan formation, including heparan sulfate and chondroitin sulfate biosynthetic processes, sulfation-related pathways, and N-acetylglucosamine metabolism. This points to a common theme of assembling and modifying extracellular matrix proteoglycans. Other metabolic terms present (flavonoid, thyroid hormone, xenobiotic metabolism) are broader and less defining for the cluster, but do not outweigh the dominant GAG/proteoglycan signal.","confidence":"","size":17,"edges":7,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000103","count":15},{"id":"GO:0030210","count":15},{"id":"GO:0030206","count":15},{"id":"GO:0009812","count":15},{"id":"GO:0042403","count":15}]},{"hash":"986009178415899430","title":"Forebrain development and vascular signaling","description":"This cluster is anchored by GO terms for forebrain development and angiotensin-related signaling and blood pressure regulation, suggesting a neurovascular signaling role during brain development. While there are also terms for GTPase regulation, microtubule polymerization, RNA processing, and endocytosis, these appear as supporting cellular processes rather than the core theme. ","confidence":"Medium","size":17,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0038166","count":1},{"id":"GO:0008217","count":1},{"id":"GO:0031116","count":1}]},{"hash":"1938106060515156047","title":"Developmental Gene Regulation","description":"The cluster\u2019s top GO terms center on multicellular development (development, growth, neural tube closure) and transcriptional regulation (DNA-templated transcription, histone H3 acetylation), with a hint of signaling via positive regulation of GTPase activity. While a few terms touch on defense or stress, the developmental and gene-expression themes are most representative of the set. Confidence: Medium","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0007568","count":5},{"id":"GO:0007275","count":4},{"id":"GO:0006349","count":4}]},{"hash":"157222623140031743","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":125,"triangles":536,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":4},{"id":"GO:0051591","count":3},{"id":"GO:0032981","count":2},{"id":"GO:0001682","count":2},{"id":"GO:0009793","count":2}]},{"hash":"1530178869516988182","title":"Vascular development and endothelial signaling","description":"Based on the top GO terms, several entries relate to endothelial cells and vascular processes (endothelial differentiation, activation, blood coagulation) and developmental signaling (BMP regulation, ureteric bud development). While there are outliers like neuron apoptotic regulation and transcription control, the strongest clustering signal is vascular development and endothelial function, suggesting these proteins collectively participate in vascular/endothelial signaling pathways.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0030277","count":1},{"id":"GO:0045446","count":1},{"id":"GO:0030514","count":1}]},{"hash":"1086749535954413875","title":"Ubiquitin-dependent regulation of signaling and cell cycle","description":"The cluster\u2019s top GO terms cluster around ubiquitin-mediated protein turnover (ubiquitin-dependent protein catabolic process, autoubiquitination, K63-linked ubiquitination) and its impact on signaling pathways (regulation of JNK cascade, positive regulation of GTPase activity) and the cell cycle. This points to a core theme of ubiquitin-modulated regulation of cellular signaling and proliferation. Some additional terms (anterior synaptic vesicle transport, rDNA heterochromatin formation, vitamin D response) reflect broader roles of ubiquitination in trafficking and chromatin/transcription, reinforcing the ubiquitin-centric view of this cluster.","confidence":"High","size":17,"edges":13,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0070534","count":3},{"id":"GO:0007049","count":3}]},{"hash":"1178587855726795868","title":"Ribosome Biogenesis and Translation Machinery","description":"The dominant GO terms are about translation, ribosomal large subunit assembly, ribosome biogenesis, and translational termination, pointing to a cluster of proteins involved in protein synthesis and ribosome maturation. Additional terms like response to antibiotic and stringent response suggest translation is modulated under stress, with a few outliers (e.g., glial cell proliferation) likely incidental. Overall, the theme is ribosome function and protein synthesis.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":14},{"id":"GO:0000027","count":6},{"id":"GO:0006415","count":4},{"id":"GO:0046677","count":3},{"id":"GO:0042254","count":3}]},{"hash":"180497657581285449","title":"Membrane Transporters and Embryogenesis Signaling","description":"This cluster is dominated by several membrane transport GO terms (myo-inositol, pantothenate, biotin, glucose transport; sodium export) and also includes developmental signaling terms (canonical Wnt signaling, Spemann organizer formation, embryonic morphogenesis). The combination suggests proteins that function as membrane transporters and may be tied to embryogenic signaling processes, hence a label that reflects both themes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015798","count":2},{"id":"GO:0015887","count":2},{"id":"GO:0008292","count":2},{"id":"GO:0071436","count":2},{"id":"GO:0015878","count":2}]},{"hash":"1384598037923033695","title":"ER-Golgi Organization and Neural Cytokine Signaling","description":"This cluster centers on ER and Golgi organization and membrane fusion, with protein homooligomerization as a supporting theme, indicating roles in protein processing and trafficking. The presence of terms related to glial differentiation, neuromuscular junction regulation, and production of cytokines (IL-1\u03b2, IL-18, IL-2) suggests a neural development context intertwined with immune signaling, implying a coordinated ER-Golgi\u2013associated function in neural and inflammatory processes.","confidence":"Medium","size":17,"edges":38,"triangles":2,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":5},{"id":"GO:0045687","count":4},{"id":"GO:0007030","count":4},{"id":"GO:0016320","count":4},{"id":"GO:1900041","count":4}]},{"hash":"917342376329653904","title":"mRNA capping and translation machinery","description":"The cluster is enriched for RNA processing and translation-related terms, notably 7-methylguanosine mRNA capping (GO:0006370) and RNA (guanine-N7)-methylation (GO:0036265), plus translation (GO:0006412) and related protein folding; a mitochondrial import term (GO:0030150) suggests some proteins are targeted to mitochondria. While terms like xenobiotic response and epinephrine biosynthesis appear, the strongest shared function is RNA cap formation and translation, indicating a unit focused on mRNA maturation and protein synthesis.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":5},{"id":"GO:0006370","count":5},{"id":"GO:0010243","count":5},{"id":"GO:0031100","count":5},{"id":"GO:0036265","count":5}]},{"hash":"1487061742708959189","title":"Heat shock response and protein quality control","description":"The terms cluster around heat stress and protein quality control (response to heat, unfolded protein response, negative regulation of inclusion body assembly, and protein folding), suggesting a module that maintains protein homeostasis under thermal stress. A couple of other terms (DNA replication and translation) appear but are likely background functions.","confidence":"Medium","size":17,"edges":58,"triangles":69,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0045454","count":1},{"id":"GO:0035719","count":1},{"id":"GO:0051259","count":1}]},{"hash":"1816559208716367583","title":"Integrin signaling and cytoskeletal regulation","description":"The top GO terms cluster around integrin-mediated signaling, regulation of cell adhesion via integrins, stress fiber and actin cytoskeleton remodeling, and related signaling pathways, with additional notes on polarity establishment and growth-related signaling. This points to a cohesive module centered on cell-matrix adhesion and cytoskeletal dynamics.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071320","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0051492","count":3},{"id":"GO:0060396","count":3},{"id":"GO:0008285","count":3}]},{"hash":"763205853806457321","title":"Membrane Transporters for Ions and Sugars","description":"The top GO terms cluster around transmembrane transport of various solutes, including nitrite/nitrate, sodium, phosphate ions, and sugars (galactose, arabinose, fucose), as well as vitamin transport and even neurotransmitter loading into vesicles. This pattern strongly suggests a group of membrane transporter proteins specialized in importing or moving solutes across membranes.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015707","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0006004","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0042891","count":2}]},{"hash":"699749371488932822","title":"Unknown","description":"The GO terms are diverse and only loosely related (viral process; various signaling pathway regulations; progenitor cell differentiation; nuclear membrane organization; endothelial migration). There is no single cohesive function tying the proteins together, and the cluster has no edges, suggesting a lack of a clear common role.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":2},{"id":"GO:0045950","count":1},{"id":"GO:0030514","count":1},{"id":"GO:0032926","count":1},{"id":"GO:1905456","count":1}]},{"hash":"1298788809851900087","title":"Chromatin Remodeling and Transcription Regulation","description":"The cluster shows strong enrichment for DNA-templated transcription regulation and initiation (GO:0045892, GO:0006352), RNA Pol II preinitiation complex assembly (GO:0051123), transcription initiation, and chromatin-modifying activities (chromatin remodeling GO:0006338; histone acetylation GO:0043968/GO:0043967). These together point to proteins that regulate gene expression by modulating chromatin state and assembling transcription machinery, rather than cytoplasmic signaling. A single term about antimicrobial peptide production is incidental and doesn\u2019t define the group; DNA repair appears as a minor related process. Confidence arises from the cohesive nuclear function theme: Chromatin Remodeling and Transcription Regulation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045892","count":2},{"id":"GO:0002225","count":1},{"id":"GO:0043968","count":1},{"id":"GO:0006281","count":1},{"id":"GO:0042993","count":1}]},{"hash":"815545570649256714","title":"Redox Homeostasis and Antioxidant Detoxification","description":"These proteins are enriched for redox-related processes\u2014cell redox homeostasis, cellular oxidant detoxification, and glutathione metabolic process\u2014pointing to a common function in maintaining oxidative balance. Additional GO terms suggest modulation of inflammatory and stress-responsive signaling (e.g., JUN kinase and TNF signaling) and regulation of calcium release, which are often linked to redox status. While a translation elongation term appears, the dominant theme is antioxidant defense and redox regulation.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0045454","count":16},{"id":"GO:0098869","count":16},{"id":"GO:2000255","count":16},{"id":"GO:0071638","count":13},{"id":"GO:2000469","count":13}]},{"hash":"931644172335231945","title":"Mitochondrial metabolism and vascular development","description":"The cluster centers on mitochondrial-related processes (aerobic respiration; protein import into the mitochondrial matrix; regulation of mitochondrial fusion) and includes tags for prenylation/CAAX processing, which ties to membrane-associated signaling. It also contains terms for vasculogenesis and angiogenesis, suggesting a link between mitochondrial function and vascular development. While the terms span metabolism, protein modification, and vessel formation, their co-occurrence implies a cohesive theme around mitochondrial influence on cellular architecture and angiogenic processes. ","confidence":"Medium","size":17,"edges":131,"triangles":607,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0009060","count":2},{"id":"GO:0030150","count":2},{"id":"GO:0071586","count":1},{"id":"GO:0030327","count":1},{"id":"GO:0010637","count":1}]},{"hash":"1551368539434025703","title":"Neural signaling and synaptic plasticity","description":"The frequent GO terms point to neural communication and plasticity (social behavior; long-term potentiation/depression; sensory perception), with additional chemical/ion response terms, suggesting a cluster of proteins involved in synaptic signaling and sensory processing.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":4},{"id":"GO:1900273","count":4},{"id":"GO:0060292","count":4},{"id":"GO:0010226","count":3},{"id":"GO:0060992","count":3}]},{"hash":"904631075401766135","title":"Reproduction and Hormone Metabolism","description":"These proteins show a strong emphasis on reproductive biology, with GO terms like uterus development, sex differentiation, maternal processes in parturition, and prostaglandin biosynthesis suggesting roles in pregnancy and reproductive signaling. The presence of omega-hydroxylase P450 pathway and calcitriol biosynthesis indicates involvement in steroid/hor\u00admone metabolism that can support reproductive function. Some terms appear unrelated (carbazole and vancomycin biosynthesis), but the core pattern points to reproduction and hormone-associated metabolism.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0046232","count":15},{"id":"GO:0060065","count":12},{"id":"GO:0060736","count":11},{"id":"GO:0033072","count":11},{"id":"GO:0036378","count":11}]},{"hash":"1183631742039524015","title":"P450-Mediated Lipid and Reproductive Hormone Metabolism","description":"The cluster's top GO terms cluster around cytochrome P450\u2013driven pathways (omega-hydroxylase and epoxygenase) that govern lipid and hormone biosynthesis, including prostaglandin production, calcitriol (vitamin D) synthesis, and triglyceride metabolism, alongside reproductive developmental processes (sex differentiation, maternal parturition, prostate growth). A single term about vancomycin biosynthesis appears as noise within the set. This suggests a cohesive theme of P450-associated lipid and hormone metabolism in reproductive contexts.","confidence":"Medium","size":17,"edges":35,"triangles":27,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0060736","count":8},{"id":"GO:0033072","count":8},{"id":"GO:0036378","count":8},{"id":"GO:0097267","count":8},{"id":"GO:0006641","count":8}]},{"hash":"375896889037664728","title":"Mitochondrial transport and energy regulation","description":"The cluster centers on GO terms for transmembrane transport of mitochondrial cofactors and ions (heme, thiamine pyrophosphate, CoA, magnesium) and regulation of mitochondrial membrane potential, alongside metabolic signaling terms (adaptive thermogenesis, insulin response, glucose-stimulated regulation). This pattern points to coordinated mitochondrial transport and energy homeostasis, integrating nutrient sensing, energy expenditure, and metabolic states like pregnancy and liver regeneration.","confidence":"High","size":17,"edges":17,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0015886","count":13},{"id":"GO:1990845","count":11},{"id":"GO:0030974","count":11},{"id":"GO:0007565","count":11},{"id":"GO:0032869","count":11}]},{"hash":"453664136707189149","title":"Embryonic Development and Organogenesis","description":"The terms cluster around broad developmental processes across multiple tissues, including endocrine development, placenta and pancreatic cell development, cartilage morphogenesis, EMT in heart development, left-right patterning, trophoblast differentiation, and structures like the roof of the mouth and retina. This pattern indicates a general role in embryogenesis and organ formation rather than a single pathway.","confidence":"High","size":17,"edges":18,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":13},{"id":"GO:0060806","count":13},{"id":"GO:0003323","count":13},{"id":"GO:0060536","count":13},{"id":"GO:0003198","count":13}]},{"hash":"1878736130345956796","title":"Fatty acid metabolism and transport","description":"Dominant GO terms point to the metabolism of long-chain and very long-chain fatty acids, their import into cells, and carnitine-related processes, with additional related catabolic pathways; together these indicate a cohesive lipid metabolism cluster focused on fatty acid processing and transport, despite minor noise from other metabolic terms.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902987","count":13},{"id":"GO:0043041","count":12},{"id":"GO:0019654","count":12},{"id":"GO:0090410","count":12},{"id":"GO:0001676","count":12}]},{"hash":"1403480893935730241","title":"Synaptic vesicle trafficking and neuronal development","description":"This cluster centers on neuronal vesicle dynamics and synaptic function, highlighted by terms for presynaptic dense core vesicle exocytosis, ubiquitin-dependent endocytosis, and regulation of synaptic plasticity, plus a brain development signal like radial glia-guided migration. While a few terms (DNA integration, mRNA export, lipid biosynthesis, Ras signaling) are broader, the dominant theme ties to neural vesicle trafficking and synaptic regulation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":1},{"id":"GO:0031340","count":1},{"id":"GO:0099525","count":1},{"id":"GO:0090119","count":1},{"id":"GO:0046580","count":1}]},{"hash":"746459721938230967","title":"Cytoskeletal dynamics and protein turnover","description":"This cluster shows strong signals for actin/microtubule organization (lamellipodium assembly, cytoplasmic microtubule organization, mitotic spindle assembly, centrosome anchoring) and Rac-mediated actin dynamics, indicating a cytoskeleton-focused module. The co-occurrence of ubiquitin\u2011dependent proteolysis and lysosome organization suggests coordinated protein turnover that supports cytoskeletal remodeling, with an additional hint of muscle-associated localization to M-band. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":2},{"id":"GO:0007040","count":2},{"id":"GO:0006511","count":2},{"id":"GO:0034454","count":2},{"id":"GO:0031122","count":2}]},{"hash":"341323023333373205","title":"Glutamatergic Synaptic Transmission and Vesicle Exocytosis","description":"The top GO terms center on neuronal signaling, especially glutamatergic synaptic transmission, presynaptic dense core vesicle exocytosis, and vesicle fusion, with supporting roles for ion and glucose transport typical of neurons. A collagen biosynthetic term appears unrelated to the main theme, suggesting some noise, but the core signals point to synaptic transmission and vesicle trafficking in neurons.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035249","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:1904659","count":2},{"id":"GO:0032964","count":2}]},{"hash":"883087690790280060","title":"Retroviral entry, DNA integration, and latency","description":"The top GO terms cluster around steps of a viral life cycle: entry into the host cell, penetration into the nucleus, RNA-templated DNA synthesis (reverse transcription), and integration of viral DNA with establishment of proviral latency. Additional terms like DNA recombination and host mRNA regulation support genome remodeling and host responses during infection, reinforcing a retroviral infection and latency theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":9},{"id":"GO:0090502","count":6},{"id":"GO:0046718","count":5},{"id":"GO:0075732","count":5},{"id":"GO:0075713","count":5}]},{"hash":"1343965109007199561","title":"Sphingolipid signaling and inflammatory angiogenesis","description":"This cluster is dominated by terms related to sphingolipid metabolism and signaling (phytosphingosine and sphingosine biosynthesis; sphingosine-1-phosphate receptor signaling; DAG-related lipid signaling) and includes regulatory roles in inflammation (IL-1\u03b2 production, NF-kappaB signaling) and processes like angiogenesis and fibroblast proliferation, suggesting a cohesive theme around sphingolipid-mediated signaling that influences inflammatory and angiogenic responses.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006671","count":3},{"id":"GO:0032651","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0048146","count":3},{"id":"GO:0070493","count":3}]},{"hash":"2085889515872987233","title":"NAD+/Polyamine/Oxaloacetate Metabolism","description":"The cluster's top GO terms are dominated by NAD+ biosynthetic process, polyamine biosynthetic process, and oxaloacetate metabolic process, indicating a core metabolic theme. A cadmium ion response term appears among the frequent annotations, suggesting some stress-related regulation, but the dominant signals point to biosynthetic metabolism rather than a developmental or structural function. The other low-frequency terms seem incidental noise. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009435","count":9},{"id":"GO:0006596","count":9},{"id":"GO:0006107","count":9},{"id":"GO:0046686","count":9},{"id":"GO:0042158","count":9}]},{"hash":"2297117191458582081","title":"Ubiquitin-Dependent Degradation and Histone Ubiquitination","description":"These proteins are strongly linked to ubiquitin-mediated protein catabolism (including K48-linked ubiquitination and autoubiquitination) and histone ubiquitination processes, with auxiliary hints of NF-kappaB pathway activation, suggesting a cluster focused on ubiquitin-proteasome regulation and chromatin modification.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0051865","count":5},{"id":"GO:0036205","count":5},{"id":"GO:0070936","count":5},{"id":"GO:1903265","count":5}]},{"hash":"144431591353301961","title":"Unknown","description":"The terms span RNA processing (mRNA branch site recognition, rRNA maturation), development (embryonic/skin), signaling (GTPase regulation, glucose signaling), and other disparate processes, with no clear cohesive function tying all proteins together. ","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0007568","count":6},{"id":"GO:0002534","count":3},{"id":"GO:0000348","count":3},{"id":"GO:0010255","count":3}]},{"hash":"2251520177345937343","title":"Neuroimmune regulation","description":"The Top Terms show strong enrichment for innate immune processes (cellular response to lipopolysaccharide, NF-kappaB regulation, IL-6 control, chemokine production) with a few neural development and synaptic modulation terms (tangential migration to the olfactory bulb, otolith morphogenesis, regulation of excitatory postsynaptic potential). This pattern suggests a cluster whose proteins participate in immune signaling that can influence neural development and neural activity.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0051639","count":2},{"id":"GO:0043124","count":2},{"id":"GO:0090394","count":2}]},{"hash":"217129789932953951","title":"Ubiquitin-dependent protein degradation","description":"Based on the dominant GO terms, this cluster centers on ubiquitination and subsequent proteolysis, including various ubiquitin linkages (K48, K63, K6), ubiquitin-dependent ERAD, autoubiquitination, and polyubiquitination. This points to roles in proteostasis and targeted protein degradation, with additional associations to stress and signaling pathways (e.g., TNF signaling). Confidence: High","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0051865","count":6},{"id":"GO:0036205","count":6},{"id":"GO:0070936","count":6},{"id":"GO:1903265","count":6}]},{"hash":"2147011172643906823","title":"Cell envelope biosynthesis and biofilm formation","description":"The cluster shows enrichment for lipid A and LPS biosynthetic processes and biofilm formation, indicating a common theme around cell envelope biogenesis and surface-associated functions. Some terms (e.g., DNA transposition, xylan catabolic process) are less directly connected, suggesting a broader or mixed functional set within the cluster.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0042244","count":1},{"id":"GO:0019428","count":1},{"id":"GO:0034232","count":1},{"id":"GO:0036108","count":1}]},{"hash":"2134866845408956912","title":"Embryonic Development and Morphogenesis","description":"These proteins are linked to embryonic development and tissue morphogenesis across several organ systems (mesoderm, cartilage, palate, heart, eye, pancreas). The recurring GO terms for morphogenesis and development strongly indicate a shared theme of organogenesis, supporting this label.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0043200","count":2},{"id":"GO:0021631","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0035270","count":2}]},{"hash":"1718878801349578079","title":"Neuronal development and synaptic signaling","description":"The top GO terms cluster around nervous system development, axon guidance, ionotropic glutamate receptor signaling, and regulation of synapse structure or activity, with supporting terms about inner-ear labyrinth morphogenesis and calcium homeostasis in the smooth ER. While a few terms touch on amyloid formation or host defense perturbation, the dominant theme is neural development and synaptic communication, suggesting this is a neuronal/synaptic function\u2013focused cluster.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":4},{"id":"GO:0051563","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0060670","count":3},{"id":"GO:0010951","count":3}]},{"hash":"1147505867147395573","title":"Unknown","description":"The GO terms are spread across neural development (neuron projection development, CNS formation, antennal development, segment specification) and immune/host-interaction processes (symbiont entry into host cell, negative regulation of IL-6 production) plus viral/nucleic acid-related terms, showing no clear single function tying the proteins together. Confidence: None","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0032715","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0039693","count":1},{"id":"GO:0090305","count":1}]},{"hash":"1008460564880069522","title":"Inflammation-driven development and tissue remodeling","description":"This cluster combines immune/inflammatory signals (lipopolysaccharide response, type IV hypersensitivity, apoptosis execution, JNK signaling) with developmental and tissue remodeling processes (multicellular development, bronchus morphogenesis, fat cell differentiation, integrin signaling, axon regeneration). The shared theme appears to be stress-activated signaling that links inflammation with tissue development/remodeling, suggesting a coherent functional module in inflammatory response and tissue differentiation.","confidence":"Medium","size":16,"edges":111,"triangles":449,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007257","count":16},{"id":"GO:1903655","count":16},{"id":"GO:0097194","count":16},{"id":"GO:0071222","count":16},{"id":"GO:0001806","count":16}]},{"hash":"979223219605662712","title":"Eye development and light-stress response","description":"This cluster\u2019s top GO terms include retinal ganglion cell axon guidance and lens fiber morphogenesis, pointing to eye development, while several terms relate to light-related and oxidative stress responses (high light intensity, UV-A, hydrogen peroxide). Although a few developmental terms for other organs appear, the strongest signals center on ocular development combined with photic/oxidative stress responses, supporting a label focused on eye formation and light-associated protection.","confidence":"Medium","size":16,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031290","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0048538","count":3},{"id":"GO:0050821","count":2},{"id":"GO:1905907","count":2}]},{"hash":"2204748225269291102","title":"Neuronal differentiation and synaptic signaling","description":"The cluster is dominated by GO terms related to neuronal development and synaptic function, such as substantia nigra development, neuron differentiation, excitatory postsynaptic potential, and regulation of postsynaptic cytosolic calcium. This suggests a cohesive theme around neuronal maturation and synaptic activity. Some other terms (response to morphine, unfolded protein response, EMT, lymphangiogenesis) appear less related and may reflect annotation noise or broader cellular processes, but do not override the main neuronal theme.","confidence":"Medium","size":16,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0021762","count":4},{"id":"GO:0030182","count":4},{"id":"GO:0060079","count":3},{"id":"GO:0061587","count":3},{"id":"GO:0043278","count":3}]},{"hash":"1874051878839806497","title":"Immune cell differentiation and ubiquitin regulation","description":"Most of the top GO terms point to immune cell lineage differentiation (dendritic cells, memory T cells, pro-T cells) and immune regulation (mast cell cytokine production), with additional emphasis on ubiquitin pathways (ubiquitin-dependent protein catabolic process and K33-linked ubiquitination). A few terms related to skeletal muscle development and circadian rhythms appear, but the dominant theme is immune differentiation coupled to ubiquitin-mediated regulation of proteins and signaling. This suggests the cluster reflects immune development with ubiquitin-regulated signaling processes.","confidence":"Medium","size":16,"edges":94,"triangles":301,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":13},{"id":"GO:0042787","count":11},{"id":"GO:0043380","count":11},{"id":"GO:0048741","count":11},{"id":"GO:0007519","count":11}]},{"hash":"935188060998476757","title":"Unknown","description":"The Top Terms section is empty, so there is no identifiable common GO function to anchor a label to this cluster. Without shared annotations, the proteins could form a general interaction module rather than a specific pathway. If GO terms or frequencies are provided, I can propose a more precise label.","confidence":"","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":null,"top_go_terms":[]},{"hash":"37881639546118985","title":"Unknown","description":"The top terms are highly diverse, spanning insect cuticle development, synaptic regulation, various RNA processing/quality-control processes (nonsense-mediated decay, nuclear mRNA surveillance, post-transcriptional gene silencing), ribosome assembly, and viral life-cycle steps (virion assembly and release) along with SOS response. This lack of a coherent, single biological theme suggests the proteins in this cluster do not share a clear, unified function, making a precise label inappropriate beyond Unknown.","confidence":"","size":16,"edges":14,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0090394","count":1},{"id":"GO:0016584","count":1},{"id":"GO:0019068","count":1},{"id":"GO:0000184","count":1}]},{"hash":"1646559056952470421","title":"Organ and sensory morphogenesis","description":"The Top Terms include several organ morphogenesis terms (cochlea, eyelid, lung, epidermis, cardiac ventricle) suggesting a developmental theme across tissues, with one neuronal signaling term present but not dominant. This supports labeling the cluster as organ and sensory morphogenesis.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030818","count":2},{"id":"GO:0035235","count":2},{"id":"GO:0001967","count":2},{"id":"GO:0008542","count":2},{"id":"GO:0008544","count":1}]},{"hash":"1651431678101290444","title":"Chromatin Silencing and DNA Transposition","description":"The top GO terms point to chromatin state regulation (heterochromatin formation, chromatin silencing, histone deacetylation, rDNA/telomere silencing) and DNA transposition, suggesting a theme of genome organization and mobility. Some terms are obsolete or outliers, which may reflect annotation noise, and there are no network edges connecting these proteins, indicating a loosely associated set rather than a tight functional module.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":2},{"id":"GO:0061186","count":2},{"id":"GO:1900525","count":2},{"id":"GO:1900473","count":2},{"id":"GO:0061188","count":2}]},{"hash":"1542597462628385787","title":"Cardiac calcium signaling and conduction","description":"This cluster\u2019s top GO terms revolve around heart rate regulation, AV node action potential control, Purkinje signaling, left ventricular morphogenesis, and calcium ion detection, all pointing to cardiac muscle function and calcium-dependent signaling (including calcineurin-NFAT pathways) that govern cardiac conduction and development. While a couple terms touch skeletal muscle or skin, the heart-related terms predominate, supporting a cardiac-focused theme.","confidence":"Medium","size":16,"edges":15,"triangles":0,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0015031","count":3},{"id":"GO:0002027","count":2},{"id":"GO:0070886","count":2},{"id":"GO:0051533","count":2},{"id":"GO:0048741","count":2}]},{"hash":"663060613434557604","title":"Developmental Signaling and Proliferation","description":"Based on the top GO terms, the proteins are enriched for signaling and regulatory processes that drive development and cell growth, including positive regulation of GTPase activity, GPCR/PLC signaling, and responses to TGF-beta. Developmental terms such as seminiferous tubule development, skin development, and multicellular organism development, together with mitotic cell cycle and proliferation-related terms, point to a cohesive theme of developmental signaling coordinating cell proliferation. Confidence: High","confidence":"","size":16,"edges":9,"triangles":0,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0072520","count":4},{"id":"GO:0008284","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0000278","count":4}]},{"hash":"1386082588295554150","title":"Drosophila developmental and stress regulators","description":"The top GO terms point to Drosophila-specific developmental processes (posterior head segmentation, oskar mRNA translation) and stress responses (heat shock/polytene chromosome puffing, apoptosis-related terms, mitochondrial membrane permeability), with additional general regulatory activities (GTPase regulation, nuclear import). This suggests a cohesive theme around development-oriented regulation intertwined with cellular stress responses, though the set is somewhat heterogeneous, indicating a Moderate level of cohesion. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:1902108","count":1},{"id":"GO:0035289","count":1},{"id":"GO:0006915","count":1},{"id":"GO:0007427","count":1}]},{"hash":"1924113169325078907","title":"Synaptic assembly and postsynaptic regulation","description":"The cluster shows strong signals for synaptic architecture and signaling control: postsynaptic density assembly, gephyrin clustering, and cytoskeletal organization at the active zone, plus regulation of excitatory/inhibitory postsynaptic potentials and postsynaptic membrane assembly. These points collectively suggest a theme of synapse formation and modulation of synaptic signaling, with retina development appearing as contextual tissue annotation rather than the core function. Some terms like APP metabolism, iodide transport, and folic acid response are more peripheral to the main theme but may reflect broader neuronal biology.","confidence":"Medium","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":10},{"id":"GO:0008285","count":7},{"id":"GO:0090394","count":7},{"id":"GO:2000463","count":7},{"id":"GO:0097104","count":7}]},{"hash":"459436675010417460","title":"Neural signaling and hearing","description":"These GO terms point to neural signaling and auditory processing: membrane depolarization and excitatory/inhibitory postsynaptic potentials reflect synaptic transmission, cochlea development and sensation of sound tie to hearing, and posture control and cocaine response relate to neural function; negative regulation of nerve impulse transmission and neuron survival further emphasize neural signaling, with amyloid fibril formation regulation suggesting a neurodegenerative link.","confidence":"High","size":16,"edges":16,"triangles":1,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0051899","count":10},{"id":"GO:1905906","count":10},{"id":"GO:0060080","count":10},{"id":"GO:0060079","count":10},{"id":"GO:0090102","count":10}]},{"hash":"1462842455177667105","title":"Developmental Signaling and Transcription Regulation","description":"The top terms point to developmental processes across tissues (heart, Schwann cell), signaling via phosphorylation and ABA pathways, and regulation of gene expression (DNA binding, transcription regulatory region DNA binding). Together these suggest proteins involved in coordinating development through signaling and transcriptional control rather than a single tissue-specific function. Confidence: Medium","confidence":"Medium","size":16,"edges":7,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043388","count":10},{"id":"GO:0007601","count":8},{"id":"GO:0009738","count":8},{"id":"GO:0000086","count":8},{"id":"GO:0007507","count":8}]},{"hash":"1940241342826746631","title":"Neural and endocrine signaling regulation","description":"The proteins cluster around modulation of neural signaling and endocrine secretion: regulation of pain perception, morphine response, membrane potential, and IP3-mediated signaling, alongside insulin and renin secretion. Additional terms hint at broader signaling control (chemokine production, Rho signaling). Overall, these proteins likely participate in coordinated signaling regulation in nervous and hormonal contexts.","confidence":"High","size":16,"edges":80,"triangles":207,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090198","count":16},{"id":"GO:0051930","count":16},{"id":"GO:0043278","count":16},{"id":"GO:0033861","count":16},{"id":"GO:1900134","count":16}]},{"hash":"1263358248068553744","title":"PI3K/AKT-MAPK Immune-Neural Signaling","description":"This cluster is enriched for phosphoinositide 3-kinase/AKT signaling and MAPK cascade regulation (tyrosine autophosphorylation), pointing to a central tyrosine-kinase\u2013driven signaling hub. The GO terms also span immune processes (natural killer cell differentiation, type IV hypersensitivity, apoptotic regulation) and neural/developmental themes (nerve impulse transmission, embryonic morphogenesis, juxtaparanode protein localization). Together, they suggest a module where signaling pathways coordinate immune responses with neural development and maintenance.","confidence":"Medium","size":16,"edges":117,"triangles":521,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043491","count":15},{"id":"GO:0001779","count":15},{"id":"GO:0019226","count":14},{"id":"GO:0038083","count":14},{"id":"GO:0071206","count":14}]},{"hash":"125300058737651282","title":"ER-Golgi trafficking and MAPK signaling","description":"This cluster\u2019s top terms are dominated by ER-Golgi vesicle transport and Golgi organization (ER to Golgi, Golgi to ER), with a signal for positive regulation of the ERK1/2 cascade. While some terms hint at neuronal development and cell movement, the strongest cohesive theme is vesicle trafficking between the ER and Golgi, possibly linked to MAPK signaling in these processes.","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0043525","count":3},{"id":"GO:0021766","count":3},{"id":"GO:0007030","count":3},{"id":"GO:0006888","count":3}]},{"hash":"1708956239435048993","title":"Developmental Signaling and Morphogenesis","description":"This cluster centers on embryonic and organ development (e.g., kidney development, multicellular organism development) and signaling pathways that regulate cell behavior during morphogenesis (axon guidance, dendritic spine morphogenesis, planar polarity, Hedgehog/Smoothened signaling), with additional involvement in cytoskeletal remodeling and tissue patterning. Overall, a unifying theme is developmental signaling guiding morphogenesis across tissues.","confidence":"High","size":16,"edges":28,"triangles":4,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007411","count":4},{"id":"GO:0001822","count":4},{"id":"GO:0051496","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0035584","count":3}]},{"hash":"438469887622147653","title":"Glycosaminoglycan biosynthesis and related metabolism","description":"The top GO terms are dominated by glycosaminoglycan biosynthetic processes (heparin proteoglycan and chondroitin sulfate) and related carbohydrate metabolism (N-acetylglucosamine), with supporting signals from broader carbohydrate and xenobiotic metabolism. This suggests the cluster centers on glycosylation and proteoglycan assembly pathways, despite some additional, looser metabolic associations. Overall, a cohesive theme around glycosaminoglycan biosynthesis is the strongest link among the terms. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0000103","count":3},{"id":"GO:0030210","count":3},{"id":"GO:0030206","count":3},{"id":"GO:0009812","count":3}]},{"hash":"1132328304347169516","title":"Organellar transcription and RNA processing","description":"The top GO terms cluster around gene expression within organelles: mitochondrial transcription (and its regulation/termination), mitochondrial ribosome assembly, plastid rRNA transcription, chloroplast organization, and RNA processing/splicing. This points to a shared role in organellar gene expression and RNA metabolism, despite a few outliers such as endothelial proliferation and DNA transposition that may be annotation noise or multi-functional proteins.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090502","count":2},{"id":"GO:0001935","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0006390","count":1},{"id":"GO:0061668","count":1}]},{"hash":"303667040409425334","title":"Membrane Transport of Ions and Nutrients","description":"Based on the top GO terms, the cluster is enriched for transmembrane transport activities (sodium, nitrite, nitrate, galactose, fucose, vitamins, etc.) and related vesicle loading, indicating a transporter or transporter-regulating role. A few terms pertain to DNA replication regulation and UV repair, but the dominant signal centers on membrane transport and nutrient handling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0033262","count":2},{"id":"GO:0070914","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0042128","count":2}]},{"hash":"2210874746899360146","title":"Proteoglycan biosynthesis and chondrocyte development","description":"The top GO terms cluster around biosynthesis and metabolism of proteoglycans and glycosaminoglycans (chondroitin/dermatan/heparan sulfate) and a link to chondrocyte development, pointing to cartilage extracellular matrix assembly and remodeling. Although some terms are marked obsolete and a few transport terms appear, the dominant theme is proteoglycan production and ECM-related cartilage biology.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030206","count":4},{"id":"GO:0015015","count":4},{"id":"GO:0006828","count":3},{"id":"GO:0098703","count":3},{"id":"GO:0033037","count":3}]},{"hash":"1057048552193672276","title":"Cardiac conduction and potassium transport","description":"Top GO terms are dominated by cardiac electrical activity: AV node action potential, ventricular repolarization, atrial and ventricular membrane depolarization, regulation of heart rate by cardiac conduction, and potassium ion transmembrane transport. This points to genes involved in cardiac rhythm control and ion channel function; additional terms like ossification and cold response are less central but can appear due to pleiotropy. Overall, the cluster represents cardiac conduction and potassium-channel\u2013related processes.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0060307","count":3},{"id":"GO:0060081","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0060371","count":3}]},{"hash":"667851453501446749","title":"Microbial lipid biosynthesis and metabolism","description":"The cluster\u2019s top GO terms cluster around biosynthetic and metabolic processes, with a strong emphasis on lipid-related pathways (fatty acid elongation, mycolic acid biosynthesis, 3-keto-sphinganine metabolism, poly-hydroxybutyrate biosynthesis) and related metabolite production (acetoin catabolic process, tetrahydrobiopterin and retinal/estrogen biosynthesis). The prominence of lipid and bacterial metabolism terms, including mycolic acid and PHB biosynthesis, suggests a bacterial metabolic module; the presence of transcription regulation and antibiotic response hints at coordinated regulation under stress. Overall, it points to microbial lipid and metabolite biosynthesis as the defining theme.","confidence":"Medium","size":16,"edges":118,"triangles":532,"max_degree":15,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":16},{"id":"GO:0006729","count":16},{"id":"GO:0045150","count":16},{"id":"GO:0030497","count":16},{"id":"GO:0071768","count":16}]},{"hash":"1278725869614849792","title":"Plant Fatty Acid Metabolism and Seed Coat Development","description":"The top GO terms are dominated by fatty acid metabolism (long-, very long-, medium-chain; import; catabolic processes) and related lipid pathways, with additional plant-specific processes like phenylpropanoid metabolism and seed coat development. This points to a cohesive plant lipid-metabolism\u2013seed biology theme across the cluster, despite some broader metabolic terms.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043041","count":14},{"id":"GO:0019654","count":14},{"id":"GO:0090410","count":14},{"id":"GO:0001676","count":14},{"id":"GO:0010124","count":14}]},{"hash":"833002235967287470","title":"Mycolic and lipid biosynthesis cluster","description":"This cluster is dominated by lipid metabolism terms: methyl-branched fatty acid biosynthetic process, fatty acid elongation, mycolic acid biosynthetic process, and 3-keto-sphinganine metabolic process, suggesting a cohesive theme around complex lipid biosynthesis (including mycolic acids) in the associated proteins. Additional terms like retinal metabolism and various catabolic/cofactor pathways appear, but the recurring lipid biosynthesis signals point to a module of lipid production and remodeling; the presence of regulation of DNA-templated transcription hints at transcriptional control of these pathways.","confidence":"Medium","size":16,"edges":113,"triangles":469,"max_degree":15,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":16},{"id":"GO:1902321","count":16},{"id":"GO:0006706","count":16},{"id":"GO:0006729","count":16},{"id":"GO:0045150","count":16}]},{"hash":"1635613240078606763","title":"Blood and immune cell development","description":"The top GO terms point to hematopoietic lineages and immune-related processes, including megakaryocyte development, platelet formation, neutrophil degranulation, and regulation of T cell activity, with additional mentions of xenobiotic response and NF-kappaB signaling. While a few terms pertain to broader developmental processes (heart development, pigmentation), the majority support a cohesive theme of blood cell formation and immune function.","confidence":"Medium","size":16,"edges":9,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035234","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0046007","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0035855","count":3}]},{"hash":"2074734339524663680","title":"Vesicle trafficking and organelle transport","description":"The top GO terms cluster around intracellular transport and vesicle dynamics: microtubule-based movement, ER inheritance, exocyst assembly, vesicle tethering in exocytosis, and Golgi to plasma membrane transport, indicating a cohesive theme of vesicle trafficking and organelle maintenance. A few terms (DNA transposition, single fertilization, endothelial cell proliferation) are less related and may reflect broader protein roles or annotation noise, but the dominant signals point to vesicle transport functions.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007018","count":2},{"id":"GO:0031954","count":2},{"id":"GO:0007338","count":2},{"id":"GO:0001845","count":2},{"id":"GO:0001935","count":2}]},{"hash":"353210710010817091","title":"Brain synaptic signaling and protein trafficking","description":"The top GO terms cluster around neuronal signaling (excitatory postsynaptic potential, postsynaptic calcium regulation) and brain development in the substantia nigra, with morphine response suggesting dopaminergic signaling. In addition, ER-to-Golgi transport and unfolded protein response point to secretory pathway\u2013related protein processing, which supports synaptic function in neurons. Overall, the cluster seems to reflect brain-related synaptic signaling with a protein trafficking component.","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":5},{"id":"GO:0060079","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0032516","count":3},{"id":"GO:0035690","count":3}]},{"hash":"1319216597098264210","title":"P-body mRNA decay and deadenylation","description":"The GO terms show strong emphasis on mRNA tail shortening, deadenylation-dependent decay, and decapping (both deadenylation-dependent and -independent), plus cytoplasmic mRNA processing body assembly, all pointing to RNA stability and decay as the cluster\u2019s core function. Some terms like DNA integration or symbiont-host interactions appear peripheral, but the dominant signal is mRNA metabolism and post-transcriptional regulation.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":2},{"id":"GO:0015074","count":1},{"id":"GO:0000289","count":1},{"id":"GO:0000288","count":1},{"id":"GO:0000290","count":1}]},{"hash":"1399063060807753364","title":"mRNA processing and translation control","description":"The top GO terms cluster around post-transcriptional RNA processing: multiple spliceosome-related splicing and its regulation, polyadenylation regulation and tail shortening, mRNA stabilization, plus a term linking to IRES-dependent translation initiation. A single ribosomal small subunit assembly term also aligns with RNA-level regulation of gene expression. Taken together, these suggest a functional group focused on RNA processing and control of translation, rather than a single enzymatic activity. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":1},{"id":"GO:1900363","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0060211","count":1},{"id":"GO:0000028","count":1}]},{"hash":"1821129245178178465","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0019068","count":3},{"id":"GO:0030260","count":3}]},{"hash":"2099139216843182417","title":"Inflammation-driven vascular remodeling","description":"The top GO terms point to immune and inflammatory processes (response to lipopolysaccharide, leukocyte tethering/rolling, complement activation) alongside vascular-related functions (angiogenesis, endothelial barrier establishment, ECM remodeling and elastin catabolism). This suggests a cohesive theme of inflammation interacting with vascular remodeling and endothelial biology.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902947","count":11},{"id":"GO:1903238","count":11},{"id":"GO:2000097","count":11},{"id":"GO:0071333","count":11},{"id":"GO:0032496","count":11}]},{"hash":"1713824455172496505","title":"Embryonic Development and Morphogenesis","description":"The top GO terms cluster around embryonic development and tissue morphogenesis, including placenta and pancreatic cell development, cartilage formation, EMT in heart development, and left-right patterning, suggesting a shared role in embryo patterning and organ formation; a few terms on splicing/regulation are present but do not define the main theme.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0003198","count":3}]},{"hash":"1814405361021927983","title":"Embryonic development and transcription regulation","description":"This cluster centers on developmental processes in embryos (digestive tract morphogenesis, neural crest migration, endocrine pancreas development, ureteric bud morphogenesis) and key transcription-related activities (negative regulation of transcription by RNA polymerase II, DNA-templated transcription, RNA polymerase III preinitiation complex assembly), with some associated cell division and synaptic/endothelial maturation terms. The shared theme is coordinated transcriptional control guiding organogenesis and embryonic development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0048557","count":3},{"id":"GO:0001755","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0031018","count":3}]},{"hash":"379591571042125889","title":"Embryogenesis and Organogenesis","description":"The cluster\u2019s top GO terms center on embryonic development and organ patterning (placenta, pancreas, cartilage, heart/cardiac cushion EMT, left-right patterning), indicating a shared theme of developmental differentiation and morphogenesis. Ribosome biogenesis terms are present but likely reflect general protein synthesis during growth rather than a single pathway. Overall this suggests a label focusing on developmental processes.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0035270","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0060536","count":2}]},{"hash":"449494998969477967","title":"Embryonic Development and Organogenesis","description":"The top GO terms cluster around embryonic development and organ formation, including endocrine system development, placental and pancreatic cell development, cartilage morphogenesis, EMT in heart formation, left-right patterning, and trophoblast differentiation; additional terms on RNA splicing and transcription regulation likely reflect gene-expression programs active during development.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":8},{"id":"GO:0060806","count":8},{"id":"GO:0003323","count":8},{"id":"GO:0060536","count":8},{"id":"GO:0003198","count":8}]},{"hash":"1238963855920755608","title":"Extrinsic apoptosis signaling and mitochondrial cytochrome c release","description":"The top GO terms are dominated by extrinsic apoptotic signaling via death domain receptors and the regulation of cytochrome c release from mitochondria, including signaling without ligand, which together point to an apoptosis-focused module with mitochondrial involvement. A few unrelated terms appear (e.g., visual perception, tRNA biosynthesis), likely representing annotation noise, but the core signal is clearly apoptotic signaling. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008625","count":1},{"id":"GO:0090200","count":1},{"id":"GO:0097192","count":1},{"id":"GO:0010923","count":1},{"id":"GO:0001844","count":1}]},{"hash":"1973303579427790647","title":"Endomembrane Vesicle Trafficking and SNARE Regulation","description":"Most terms describe intracellular transport and membrane fusion within the endomembrane system (endosome-lysosome transport, vesicle tethering, SNARE complex assembly regulation, vacuole fusion), suggesting these proteins function together in vesicle trafficking. A couple of terms appear unrelated noise.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0008333","count":2},{"id":"GO:0099022","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0035542","count":2}]},{"hash":"777715071797537819","title":"Immune-ECM remodeling and angiogenesis","description":"The GO terms cluster around immune activation (lipopolysaccharide response, classical complement activation), extracellular matrix remodeling (elastin catabolic process, regulation of smooth muscle cell-matrix adhesion), and angiogenesis, suggesting a theme of inflammation-associated vascular remodeling; transcription regulation appears more peripheral.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":3},{"id":"GO:0007601","count":2},{"id":"GO:1902947","count":2},{"id":"GO:1903238","count":2},{"id":"GO:2000097","count":2}]},{"hash":"275927565483099292","title":"Membrane Transporters for Ions and Amino Acids","description":"The top GO terms point to transmembrane transport of various solutes (ions, amino acids, GABA, polyamines, carnitine) and related osmoregulatory processes, suggesting a cluster of membrane transporter proteins involved in solute uptake and cell volume regulation. Some terms are obsolete or tangential (host defense perturbation), but the core theme is solute transport across membranes.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035826","count":3},{"id":"GO:0098713","count":3},{"id":"GO:1902274","count":3},{"id":"GO:0070634","count":3},{"id":"GO:0015812","count":3}]},{"hash":"2145643180384180921","title":"Unknown","description":"The Top Terms are very diverse, including DNA transposition and transcription regulation, apoptosis and mitochondrial membrane permeability, endothelial proliferation, epithelial cell migration, and Drosophila-specific developmental processes (posterior head segmentation and oskar mRNA translation), plus far-red light signaling. No single coherent function or pathway ties these terms together, making it unclear what unifies this cluster.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0001935","count":2},{"id":"GO:1902108","count":2},{"id":"GO:0035289","count":2}]},{"hash":"2302440134521434515","title":"Virus-host interaction and endosomal trafficking","description":"Proteins in this cluster are enriched for viral infection-related processes: endosomal transport, virion assembly, proviral latency, and host entry, plus symbiont-mediated host responses. Some transcription-regulation terms may reflect host response to infection, but the overall pattern points to viral life cycle and host interaction coupled with endosomal trafficking. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045022","count":3},{"id":"GO:0008333","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0034244","count":2},{"id":"GO:0007507","count":2}]},{"hash":"892114559006634155","title":"Unknown","description":"The top GO terms are a mix of plant-specific processes (root hair development, seed coat mucilage, arabinogalactan protein metabolism, plastid DNA replication) and animal/insect processes (myotome development, insect visual primordium formation, thigmotaxis, IL-6 production), with no clear single theme tying the cluster together. Additionally, there are no edges or interactions, suggesting disparate proteins rather than a cohesive module, so there is no well-supported shared function.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010738","count":2},{"id":"GO:0033259","count":2},{"id":"GO:0001966","count":1},{"id":"GO:0042226","count":1},{"id":"GO:0061055","count":1}]},{"hash":"292823091354574593","title":"Reelin-mediated synaptic maturation and motor neuron migration","description":"The GO terms point to a coordinated role in neuronal development and synaptic regulation: reelin signaling, NMDA receptor activity, dendritic spine morphogenesis, and glutamatergic transmission, along with ventral spinal cord and lateral motor column neuron migration, indicating both neuronal migration during development and maturation of excitatory synapses. This makes a cohesive cluster theme around reelin-driven synaptic development and motor neuron positioning.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038026","count":2},{"id":"GO:1900273","count":2},{"id":"GO:0042832","count":2},{"id":"GO:0051968","count":2},{"id":"GO:2000310","count":2}]},{"hash":"1941965235514329724","title":"MAPK/ERK signaling and angiogenesis","description":"The top GO terms cluster around ERK1/ERK2 cascade and related signaling (including long-term potentiation), with supporting themes of cyclic nucleotide biosynthesis and transcription, plus angiogenesis and cell-cycle progression. This points to a cohesive group of proteins involved in MAPK-driven signaling that controls growth, proliferation, and vascular development, with some additional terms reflecting broader cellular responses. Confidence: High","confidence":"","size":15,"edges":5,"triangles":1,"max_degree":2,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0009190","count":3},{"id":"GO:0006281","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0001525","count":3}]},{"hash":"116075096669652884","title":"Growth control, differentiation, autophagy, and innate immunity","description":"This cluster centers on growth-regulating pathways (Hippo, Wnt) and cell cycle/apoptosis, with notes on differentiation (keratinocyte). It also includes autophagy-related terms and innate immune/defense responses, suggesting a cohesive theme around coordinating cell growth, stress responses, differentiation, and immune-autophagic processes.","confidence":"Medium","size":15,"edges":59,"triangles":155,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006915","count":6},{"id":"GO:0007049","count":5},{"id":"GO:0060044","count":5},{"id":"GO:0035329","count":5},{"id":"GO:0030512","count":5}]},{"hash":"1565512156908412925","title":"RNA Splicing Regulation and Post-Transcriptional Control","description":"The cluster is enriched with terms related to RNA processing and gene expression control: positive regulation of mRNA splicing via the spliceosome, transcription regulation by RNA polymerase II, regulatory ncRNA-mediated gene silencing, nonsense-mediated decay, post-transcriptional gene silencing, spliceosomal conformational changes, ribosome assembly, and related RNA decay pathways. This combination points to a cohesive role in RNA maturation and post-transcriptional regulation of gene expression, rather than a single enzymatic activity family. Some terms touch on neural signaling, but the dominant theme is RNA processing and gene expression control.","confidence":"High","size":15,"edges":9,"triangles":0,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":4},{"id":"GO:0045944","count":4},{"id":"GO:0031047","count":3},{"id":"GO:0090394","count":3},{"id":"GO:0071035","count":3}]},{"hash":"1600408299363057665","title":"DNA Repair and Transport Protein Cluster","description":"Based on the GO terms, the cluster centers on DNA damage response (nucleotide-excision repair; SOS response) and shows a broad representation of transport-related processes (mRNA export, xenobiotic export, carbohydrate and amino acid transport, cysteine and taurine transport) plus protein processing/assembly (cytochrome complex assembly) and even antigen processing via MHC I. This pattern suggests a cohesive but broad grouping around genomic maintenance and intracellular transport/processing rather than a single specific pathway, hence the label.","confidence":"Medium","size":15,"edges":68,"triangles":170,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006289","count":5},{"id":"GO:0009432","count":5},{"id":"GO:0006406","count":4},{"id":"GO:0046618","count":4},{"id":"GO:0008643","count":4}]},{"hash":"1805540012440724167","title":"Photosynthesis and Aromatic Compound Metabolism","description":"Most prominent GO terms are photosynthesis and nonphotochemical quenching, pointing to chloroplast energy capture, supported by several aromatic compound catabolic processes (carbazole and toluene). Proton transmembrane transport also fits chloroplast/metabolic activity. A few immune-related terms appear peripheral and likely noise. Overall, the cluster centers on photosynthesis-linked metabolism with associated xenobiotic/aromatic compound catabolism.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0015979","count":4},{"id":"GO:0046232","count":3},{"id":"GO:0046381","count":3},{"id":"GO:1902600","count":3},{"id":"GO:0042203","count":3}]},{"hash":"1764801623904026410","title":"mRNA Splicing and Processing Regulation","description":"The top GO terms center on mRNA splicing via the spliceosome, regulation of alternative splicing, polyadenylation and poly(A) tail dynamics, mRNA stability, and even IRES-dependent translation\u2014together indicating a cohort involved in post-transcriptional processing and control of mRNA fate. Confidence: High","confidence":"","size":15,"edges":17,"triangles":7,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":9},{"id":"GO:0006378","count":9},{"id":"GO:0000381","count":8},{"id":"GO:0010610","count":8},{"id":"GO:1900363","count":7}]},{"hash":"757249642495891665","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":99,"triangles":386,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0016973","count":3},{"id":"GO:0090394","count":2},{"id":"GO:0071035","count":2},{"id":"GO:0000393","count":2},{"id":"GO:0006268","count":2}]},{"hash":"1170782784191312822","title":"Drosophila Developmental and Reproductive Processes","description":"The top GO terms point to Drosophila-specific developmental and reproductive functions\u2014posterior head segmentation, oskar mRNA translation regulation during oogenesis, mating plug formation, and copulation\u2014with additional apoptosis-related terms that can occur during development. This suggests a cluster centered on Drosophila developmental and reproductive biology, with some involvement of cell death pathways.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902108","count":2},{"id":"GO:0035289","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0007427","count":2},{"id":"GO:0046011","count":2}]},{"hash":"571135021239873926","title":"ER Stress and Protein Folding Quality Control","description":"The cluster is dominated by GO terms tied to the endoplasmic reticulum stress response, unfolded protein response, chaperone-assisted refolding, N-glycan processing, and ER-associated degradation, all pointing to maintenance of protein folding and processing in the secretory pathway. A few terms related to cell signaling or the cell cycle appear, but the core theme centers on ER quality control and translation regulation under stress.","confidence":"Medium","size":15,"edges":13,"triangles":0,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":6},{"id":"GO:0006469","count":5},{"id":"GO:0006986","count":5},{"id":"GO:0036494","count":5},{"id":"GO:0070389","count":5}]},{"hash":"1559058249328000207","title":"Neuronal development and synaptic signaling","description":"This cluster is dominated by GO terms related to nervous system development, axon guidance and remodeling (nervous system development; axon midline choice point recognition; collateral sprouting; branching morphogenesis), and synaptic function (ionotropic glutamate receptor signaling), with supporting notes on neuronal calcium homeostasis. A few outlier terms (amyloid fibril formation, symbiont-host interactions) likely reflect annotation noise rather than a true cluster theme, but the neural development/synaptic signaling signal is strong and coherent.","confidence":"High","size":15,"edges":45,"triangles":40,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0009405","count":2},{"id":"GO:0030682","count":2},{"id":"GO:0051563","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0060670","count":2}]},{"hash":"1586517009000830757","title":"Drosophila Developmental and Morphogenetic Processes","description":"The top GO terms point to a suite of developmental and morphogenetic events in Drosophila and insects, including eye morphogenesis, germ-band shortening, head involution, mushroom body (neural) development, molting, and cell-cycle regulation during development. While a couple terms are more tangential (e.g., DNA transposition, response to symbiont), the overall pattern centers on developmental biology and morphogenesis, justifying a label that reflects broad insect development rather than a single pathway.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0007458","count":1},{"id":"GO:0009608","count":1},{"id":"GO:0008258","count":1}]},{"hash":"781707868077583968","title":"Long-chain fatty acid metabolism and transport","description":"The GO terms are dominated by long-chain and very long-chain fatty acid metabolic processes, including import into the cell and carnitine involvement, indicating a cluster enriched for fatty acid catabolism and transport. Other catabolic terms (malonate, phenylacetate, propionate) appear as supporting metabolic pathways, while translation is less directly related, likely background. Overall, the theme is fatty acid metabolism and related transport.","confidence":"Medium","size":15,"edges":41,"triangles":60,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0043041","count":3},{"id":"GO:0019654","count":3},{"id":"GO:0090410","count":3},{"id":"GO:0001676","count":3}]},{"hash":"394149096637613871","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":96,"triangles":355,"max_degree":14,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0071035","count":9},{"id":"GO:0000480","count":9},{"id":"GO:0000472","count":9},{"id":"GO:0034476","count":9},{"id":"GO:0000184","count":9}]},{"hash":"160920572115752834","title":"Ribosome Biogenesis and Translation Machinery","description":"The dominant GO terms are about translation, ribosome biogenesis, initiation, elongation, and termination, plus selenocysteine incorporation, indicating a core protein synthesis machinery cluster.","confidence":"","size":15,"edges":100,"triangles":394,"max_degree":14,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:0042254","count":5},{"id":"GO:0006413","count":5},{"id":"GO:0006415","count":4},{"id":"GO:0000288","count":4}]},{"hash":"2016333366435143572","title":"Organogenesis and Epithelial Morphogenesis","description":"This cluster is dominated by terms tied to organ development, especially face morphogenesis, kidney development, and lung development, along with negative regulation of epithelial cell proliferation. These points together to a cohesive theme of organ morphogenesis and epithelial tissue formation. Some terms are developmental cell-cycle related or obscure/metabolic, likely noise from annotation, but the core signal supports organogenesis and epithelial morphogenesis.","confidence":"High","size":15,"edges":15,"triangles":1,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":2},{"id":"GO:0070689","count":1},{"id":"GO:0046360","count":1},{"id":"GO:0009097","count":1},{"id":"GO:0090502","count":1}]},{"hash":"2043221157349789978","title":"Neuronal signaling and cytoskeletal dynamics","description":"Top GO terms cluster around synaptic function (excitatory postsynaptic potential, regulation of postsynaptic calcium) and neuronal development (substantia nigra development). Supporting terms point to cytoskeleton and membrane signaling (microtubule nucleation, protein dephosphorylation, regulation of cell shape), suggesting the proteins work in synaptic signaling and cytoskeletal remodeling. A few terms (complement activation, karyogamy, urea homeostasis) seem unrelated noise.","confidence":"Medium","size":15,"edges":17,"triangles":0,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006470","count":6},{"id":"GO:0060079","count":6},{"id":"GO:0045917","count":6},{"id":"GO:2000678","count":6},{"id":"GO:0000742","count":6}]},{"hash":"634210551994541418","title":"Transmembrane solute transporters","description":"The GO terms point to multiple transmembrane transport activities spanning nitrite/nitrate, various sugars, phosphate, sodium ions, vitamins, and other solutes, plus vesicular neurotransmitter loading\u2014collectively indicating a cluster of diverse membrane transport proteins rather than a single pathway. This coherent transport-focused theme justifies the label as a transporter-dominated group, despite network sparsity.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015707","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0006004","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0042891","count":3}]},{"hash":"2046558149219769769","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0000472","count":2}]},{"hash":"2103761535569418695","title":"Neural development and synaptic signaling","description":"The cluster shows strong enrichment for terms related to nervous system development, CNS development, nerve impulse transmission, and trans-synaptic signaling, suggesting the proteins participate in neuronal connectivity and synaptic communication. Additional terms like regulation of MAPK cascade and dendrite development support a neuronal signaling theme, while some terms on notochord, nephric duct, and urogenital development indicate broader developmental roles, likely reflecting multifunctional proteins. Overall, the dominant signal is neural development/synaptic signaling.","confidence":"Medium","size":15,"edges":104,"triangles":442,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0019226","count":11},{"id":"GO:0001806","count":11},{"id":"GO:0043408","count":11},{"id":"GO:0060035","count":11},{"id":"GO:0099557","count":11}]},{"hash":"267695821698443038","title":"Cytoskeleton Assembly and Proteostasis","description":"The cluster is dominated by terms for tubulin/tubulin complex assembly and cortical microtubule organization, plus protein folding and proteostasis via chaperones and the ubiquitin-proteasome system, suggesting a shared focus on cytoskeletal assembly and protein quality control. A couple of outliers (DNA transposition, endothelial cell proliferation) exist but do not define the core theme. ","confidence":"Medium","size":15,"edges":32,"triangles":39,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":4},{"id":"GO:0001935","count":3},{"id":"GO:0006457","count":1},{"id":"GO:0032968","count":1},{"id":"GO:0051131","count":1}]},{"hash":"627011323647395793","title":"Lipid Metabolism and Transcription Regulation","description":"Several top GO terms point to lipid metabolism, including methyl-branched fatty acid biosynthesis, fatty acid elongation, mycolic acid biosynthesis, and 3-keto-sphinganine metabolic process, suggesting the proteins are involved in lipid biosynthesis and lipid-derived metabolite turnover. Additional terms like retinal metabolic process and various catabolic pathways (acetoin, propylene) reinforce a metabolic network centered on lipid and related metabolite turnover. The presence of regulation of DNA-templated transcription implies some regulatory components within the cluster, aligning with a cohesive theme of lipid metabolism with transcriptional control.","confidence":"Medium","size":15,"edges":24,"triangles":12,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":13},{"id":"GO:1902321","count":13},{"id":"GO:0006706","count":13},{"id":"GO:0006729","count":13},{"id":"GO:0045150","count":13}]},{"hash":"725739210513765423","title":"Developmental signaling and morphogenesis","description":"The cluster\u2019s top GO terms span multiple developmental contexts (uterus, brain, lung, digestive tract, multicellular growth) and include key signaling pathways (Rho signaling, TGF-beta receptor signaling) and synaptic transmission. This pattern points to a shared theme of developmental processes and morphogenesis driven by signaling pathways, rather than a single tissue-specific function.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":3},{"id":"GO:0048286","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0007266","count":2},{"id":"GO:0035023","count":2}]},{"hash":"1282420497461704512","title":"Signaling Regulation and Stress Response","description":"GO terms center on phosphorylation/dephosphorylation regulation and broad signaling/stress processes across systems (angiogenesis, heart rate, synaptic potentiation, complement activation, multicellular stress responses), suggesting a general role in signaling modulation rather than a single pathway.","confidence":"Medium","size":15,"edges":14,"triangles":0,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000742","count":4},{"id":"GO:0006469","count":4},{"id":"GO:0002027","count":4},{"id":"GO:0030437","count":4},{"id":"GO:0001525","count":4}]},{"hash":"1587817635723587504","title":"Mycolic acid and lipid metabolism","description":"The top GO terms are dominated by lipid-related processes: methyl-branched fatty acid biosynthesis, fatty acid elongation, mycolic acid biosynthesis, and various lipid catabolic pathways, with additional related metabolic terms like 3-keto-sphinganine and retinal metabolism appearing but not altering the core lipid theme. This pattern suggests a cohesive cluster of proteins involved in lipid biosynthesis and breakdown, particularly mycolic acid\u2013associated pathways. ","confidence":"High","size":15,"edges":44,"triangles":52,"max_degree":10,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":15},{"id":"GO:1902321","count":15},{"id":"GO:0006706","count":15},{"id":"GO:0006729","count":15},{"id":"GO:0045150","count":15}]},{"hash":"886248073642847370","title":"Diverse lipid and metabolite biosynthesis","description":"GO terms point to biosynthesis of lipids and lipid-derived compounds (fatty acid elongation, mycolic acid, sphinganine metabolism) along with multiple metabolite biosynthesis pathways (retinal, estrogen, poly-hydroxybutyrate, tetrahydrobiopterin). While there are also regulatory and antibiotic-response terms, the dominant signal is production of diverse metabolites and lipid-related molecules.","confidence":"Medium","size":15,"edges":79,"triangles":209,"max_degree":14,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":15},{"id":"GO:0006729","count":15},{"id":"GO:0045150","count":15},{"id":"GO:0030497","count":15},{"id":"GO:0071768","count":15}]},{"hash":"1748993035283989822","title":"Vesicle-trafficking and vacuolar sorting","description":"GO terms center on localization to the cell surface, GPI-anchor attachment, and vacuolar/secretory pathway processes (cell surface localization, GPI anchoring, vacuolar protein processing, storage vacuole organization). This points to a theme of vesicle trafficking and vacuolar sorting, with a few outlier terms that are less connected to this core function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010447","count":1},{"id":"GO:0040015","count":1},{"id":"GO:0010375","count":1},{"id":"GO:1990019","count":1},{"id":"GO:0016255","count":1}]},{"hash":"895637730895353229","title":"Retroelement Integration and Proviral Latency","description":"This cluster centers on DNA-level genome integration and maintenance by mobile genetic elements, with terms for DNA integration, proviral latency, recombination, transposition, and RNA-templated DNA synthesis, all pointing to retroelements/viral provirus activity; accompanying terms about host-symbiont interactions and RNAi suppression reinforce a theme of genome manipulation by infectious elements.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0075732","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0075713","count":2}]},{"hash":"1109999517345121597","title":"Neural development and synapse assembly","description":"The top GO terms converge on neural development and synaptic organization, including retina development, postsynaptic membrane assembly, gephyrin clustering, and regulation of excitatory postsynaptic potentials. APP metabolic processes and folic acid response further support a neuronal context. Together they point to a coordinated neural development/synapse assembly theme.","confidence":"High","size":15,"edges":104,"triangles":442,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":11},{"id":"GO:0002087","count":10},{"id":"GO:0002076","count":10},{"id":"GO:0008285","count":9},{"id":"GO:0090394","count":9}]},{"hash":"259303048143098086","title":"Inflammation-driven ECM remodeling and angiogenesis","description":"The top GO terms point to immune activation (response to LPS, complement activation, leukocyte tethering/rolling) together with extracellular matrix remodeling and vascular processes (elastin catabolic process, cell-matrix adhesion, angiogenesis). This suggests a cluster shaped by inflammatory signaling driving tissue remodeling and new blood vessel formation, despite a couple of obsolete terms that are less informative. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:1902947","count":6},{"id":"GO:1903238","count":6},{"id":"GO:2000097","count":6},{"id":"GO:0071333","count":6}]},{"hash":"1789231224027305018","title":"Vascular inflammation and coagulation","description":"This cluster centers on inflammatory and coagulation-related processes, with GO terms such as positive regulation of blood coagulation, complement activation, response to lipopolysaccharide, and leukocyte tethering. Additional terms pointing to vascular remodeling (smooth muscle cell\u2013matrix adhesion) and immune signaling reinforce a theme of innate immunity interacting with coagulation in the vasculature, despite some miscellaneous terms (e.g., transcriptional regulation, biomineral development) that are less central. Overall, the dominant signal is inflammatory/coagulation activity in vessels.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031214","count":7},{"id":"GO:0030194","count":7},{"id":"GO:0042127","count":5},{"id":"GO:0000122","count":5},{"id":"GO:1902947","count":4}]},{"hash":"2204815187675062963","title":"Cholesterol Transport and Lipoprotein Remodeling","description":"The cluster is dominated by lipid metabolism and cholesterol homeostasis terms, including triglyceride catabolism and biosynthesis, lipid digestion, intestinal cholesterol absorption, and remodeling of HDL and VLDL particles, plus reverse cholesterol transport. This suggests a cohesive role in lipoprotein processing and cholesterol balance across processes, with a minor note of inflammatory chemokine regulation not defining the cluster.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":5},{"id":"GO:0044241","count":4},{"id":"GO:0034375","count":4},{"id":"GO:0043691","count":4},{"id":"GO:0034372","count":4}]},{"hash":"415457840015353521","title":"NAD+ and polyamine biosynthesis","description":"The top GO terms are dominated by biosynthetic and central metabolic processes (NAD+ biosynthetic, polyamine biosynthetic, oxaloacetate metabolic, and lipoprotein biosynthetic), suggesting a cluster of enzymes centered on cofactor production and core metabolism. A few stress-response terms (cadmium, lithium, fungicide) appear but are not predominant, supporting a metabolic-facing theme rather than a stress-response cluster.","confidence":"High","size":15,"edges":13,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0009435","count":13},{"id":"GO:0006596","count":13},{"id":"GO:0006107","count":13},{"id":"GO:0046686","count":13},{"id":"GO:0042158","count":13}]},{"hash":"531601427410914623","title":"Pheromone lipid biosynthesis and secretion","description":"The cluster shows a coherent theme around pheromone metabolism and signaling, with multiple GO terms for pheromone metabolic processes and courtship behavior, coupled with fatty acid and sphingolipid biosynthesis and long-chain fatty-acyl-CoA production. The presence of protein secretion and vesicle trafficking terms (post-Golgi transport, MVB sorting) suggests these proteins function in producing pheromone-related lipids and transporting them for secretion, fitting a unified role in pheromone production and release.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009306","count":1},{"id":"GO:0006636","count":1},{"id":"GO:0006892","count":1},{"id":"GO:0042810","count":1},{"id":"GO:0007619","count":1}]},{"hash":"2051447103590412769","title":"DNA Transposition and Proviral Integration","description":"This cluster is dominated by GO terms for DNA transposition, DNA integration, retrotransposition, and proviral latency, pointing to activity of transposable elements and integrated viral genomes. While some terms mention host-symbiont interactions, the core theme appears to be mobile genetic elements and their integration events.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":5},{"id":"GO:0015074","count":4},{"id":"GO:0000398","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0075732","count":3}]},{"hash":"1810294899154952247","title":"Unknown","description":"The terms cover immune defense, innate immunity, development, transposition, calcium homeostasis, and amyloid formation, with no single shared function or pathway tying them together. There are no edges, suggesting no cohesive interaction network. Because of this heterogeneity and lack of connectivity, a specific, representative label cannot be confidently assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0030682","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0051563","count":1}]},{"hash":"267104716536040220","title":"Neural development, synapse formation, and axon guidance","description":"This cluster\u2019s top GO terms predominantly point to nervous system development and connectivity: otolith morphogenesis, myelination, positive regulation of synapse assembly, axonal fasciculation, and lateral motor column neuron migration. Collagen fibril organization and cellular response to mechanical stimulus hint at ECM interactions involved in neural development, while a few terms (innate immune response, dendritic cell differentiation) may reflect broader developmental processes or annotation noise. Taken together, the pattern is most consistent with neural development and connectivity, with some non-neural terms present.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032474","count":3},{"id":"GO:0042552","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0007413","count":3}]},{"hash":"1086343675715724272","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":1},{"id":"GO:0042790","count":1},{"id":"GO:0006362","count":1},{"id":"GO:0001682","count":1},{"id":"GO:1905267","count":1}]},{"hash":"182071686410626529","title":"Unknown","description":"The GO terms for this cluster are highly diverse, spanning symbiont-host interactions, autophagy/Cvt pathway targeting, intracellular transport, amino acid catabolism (tyrosine/phenylalanine), endothelial proliferation, development (face morphogenesis), and DNA transposition. There isn\u2019t a single cohesive function or pathway that ties all members together, so a specific, representative label cannot be confidently assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":2},{"id":"GO:0032258","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0055114","count":1},{"id":"GO:0006572","count":1}]},{"hash":"1959551472756248926","title":"Unknown","description":"This cluster's top GO terms cover a wide range of processes across different tissues and kingdoms (e.g., transcription regulation in animals, Leydig and mammary gland development, leptin response, stomatal opening, liver regeneration, viral genome replication suppression). There isn't a single cohesive function or process linking these terms, so a specific, representative label isn't evident.","confidence":"","size":14,"edges":30,"triangles":29,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0033327","count":12},{"id":"GO:0044321","count":12},{"id":"GO:0030857","count":12},{"id":"GO:0033601","count":12}]},{"hash":"2073874190216462527","title":"Golgi-ER Secretory Pathway Regulators","description":"Most abundant terms describe components and steps of the secretory pathway (ER to Golgi transport, Golgi retention, and exosomal secretion), indicating these proteins are linked to Golgi-ER trafficking and secretion. Additional terms touch on autophagy and cell division, but the core signal centers on secretory trafficking rather than a single specialized function.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903543","count":2},{"id":"GO:0045053","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0090394","count":2},{"id":"GO:0022028","count":2}]},{"hash":"331103287490369946","title":"Unknown","description":"The top GO terms span very different biological areas (mitochondrial energy, vision, saliva secretion, blood pressure regulation, GPCR signaling, corticotropin secretion, smooth muscle proliferation, retroviral latency, and DNA recombination) with no clear shared function or interaction; coupled with zero edges, there\u2019s no cohesive functional theme to define a specific label.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022900","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0046541","count":2},{"id":"GO:0045777","count":2},{"id":"GO:0010579","count":2}]},{"hash":"863727085592677333","title":"Developmental and Immune Signaling","description":"This cluster\u2019s top GO terms span developmental processes (lung, cartilage, chitin-based cuticle development) and immune/inflammatory signaling (interleukin-1 and interleukin-6 responses, NF-kappaB activation, IL-8 production), with apoptosis also present. The lack of network edges plus the mix of terms suggests broad roles in development and immune signaling rather than a single cohesive function; hence the label reflects the dominant themes while acknowledging the heterogeneity.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030324","count":6},{"id":"GO:0006260","count":4},{"id":"GO:0006032","count":4},{"id":"GO:0072606","count":4},{"id":"GO:0007250","count":4}]},{"hash":"846517404811534155","title":"Spliceosome-Mediated Splicing and RNA Processing","description":"Dominant GO terms center on mRNA splicing via the spliceosome and its regulation (including alternative splicing), plus processes related to mRNA polyadenylation and tail shortening. This points to a cohesive RNA-processing/splicing module. While a few terms mention stress or stimulus responses, they are commonly linked to post-transcriptional control, supporting a label focused on spliceosome-driven RNA processing.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0002931","count":1},{"id":"GO:0045292","count":1},{"id":"GO:1900363","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0060211","count":1}]},{"hash":"1636194028040898233","title":"Developmental differentiation and tissue regeneration","description":"The GO terms cover diverse developmental and tissue remodeling processes (placenta, ring gland, salivary gland, brown fat differentiation, epithelial maturation) plus liver regeneration and wound healing, with transcription by RNA polymerase II as a shared regulatory mechanism and occasional immune signaling (interferon production). This points to a broad theme of developmental differentiation and tissue remodeling rather than a single pathway.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":10},{"id":"GO:0035470","count":6},{"id":"GO:0001892","count":6},{"id":"GO:0050873","count":5},{"id":"GO:0060691","count":5}]},{"hash":"1917624734111585090","title":"RRNA Processing and Ribosome Biogenesis","description":"Most of the top GO terms point to maturation/processing of ribosomal RNA (5.8S and LSU rRNA), indicating a core function in ribosome biogenesis for this cluster. The presence of ubiquitin-related terms and some development-related terms likely reflects multifunctional proteins or annotation noise, but the dominant signal is rRNA maturation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000466","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0000209","count":3}]},{"hash":"1124235079388825336","title":"Neural development and synaptic signaling","description":"The terms cluster around synaptic vesicle cycling (endocytosis and exocytosis) and synaptic transmission, including GABAergic signaling and excitatory postsynaptic potentials, with a developmental context suggested by substantia nigra development. Some terms about bone ossification and xenobiotic response are less coherent with neural function, but the dominant signal points to neural/synaptic biology.","confidence":"Medium","size":14,"edges":18,"triangles":7,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1900242","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0043931","count":6},{"id":"GO:0021762","count":6},{"id":"GO:2000300","count":6}]},{"hash":"1353794104584267633","title":"Proteostasis and Secretory Pathway Regulation","description":"The terms cluster around proteasomal ubiquitin-dependent protein degradation, RNA processing and surveillance, plus multiple steps of protein localization and trafficking to membranes and the secretory pathway (ER, Golgi, plasma membrane). This points to a coherent module governing protein quality control and movement through the secretory pathway, with some developmental transcriptional regulation signals that may reflect broader regulatory roles.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032436","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0035914","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0000973","count":2}]},{"hash":"553426089669828720","title":"DNA Damage Response and Repair","description":"The terms emphasize multiple DNA repair pathways (NER, SSB and DSB repair via NHEJ), DNA synthesis/replication, and cellular responses to DNA-damaging agents (bleomycin, X-ray), suggesting a shared role in genome maintenance and damage signaling, despite a few nonrepair terms in the mix.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0000012","count":1},{"id":"GO:1904975","count":1},{"id":"GO:0002328","count":1}]},{"hash":"650169227713646009","title":"Dopamine Metabolism and Methylation","description":"The cluster centers on dopamine/catecholamine processing and methylation-related processes, with several GO terms for dopamine catabolic/metabolic processes and methylation (including protein methylation). Auditory receptor cell development also aligns with dopamine signaling in the ear; some plant-specific biosynthetic terms may reflect annotation noise, but the core theme remains dopamine turnover coupled to methylation regulation.","confidence":"Medium","size":14,"edges":47,"triangles":62,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009236","count":9},{"id":"GO:0006479","count":8},{"id":"GO:0006584","count":8},{"id":"GO:0042135","count":8},{"id":"GO:0009809","count":8}]},{"hash":"661310205344703521","title":"Cerebellar neuron development and Bergmann glia differentiation","description":"These proteins are enriched for cerebellum-specific developmental terms\u2014cerebellar cortex formation and Bergmann glial cell differentiation\u2014along with neuron development and regulation of axon regeneration, indicating a cluster focused on cerebellar neural development and glial maturation. While other signaling terms (e.g., insulin signaling, T cell receptor signaling) appear, they seem to be supportive regulatory processes rather than the cluster\u2019s core function.","confidence":"High","size":14,"edges":36,"triangles":36,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048666","count":12},{"id":"GO:0032435","count":12},{"id":"GO:0048679","count":11},{"id":"GO:0021697","count":11},{"id":"GO:0060020","count":11}]},{"hash":"849126415645627308","title":"Golgi apparatus vesicle transport and exocytosis","description":"This label matches the dominant GO terms: intra-Golgi and ER-to-Golgi vesicle transport, Golgi ribbon formation, Golgi to vacuole trafficking, and vesicle fusion with the Golgi, plus positive regulation of calcium-dependent exocytosis. Together they describe vesicle trafficking within and from the Golgi apparatus and regulated exocytosis, suggesting the proteins function in the secretory pathway at the Golgi.","confidence":"High","size":14,"edges":15,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045956","count":3},{"id":"GO:0048280","count":3},{"id":"GO:0090161","count":3},{"id":"GO:0006891","count":3},{"id":"GO:0006896","count":3}]},{"hash":"1458063491803007092","title":"Nuclear chromatin dynamics during transcription and replication","description":"The top GO terms point to chromatin organization and dynamics (chromatin organization, mitotic chromosome condensation, rDNA heterochromatin formation) along with DNA metabolism activities (DNA topology changes, transcription elongation, DNA strand elongation in replication) and cell-cycle related processes (embryonic cleavage, nuclear migration), plus circadian regulation of gene expression. This suggests a nucleus-centered program coordinating chromatin state with transcription and DNA replication across the cell cycle.","confidence":"High","size":14,"edges":11,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":2},{"id":"GO:0007076","count":2},{"id":"GO:0000183","count":2},{"id":"GO:0007097","count":2},{"id":"GO:0032922","count":2}]},{"hash":"1984135636816321518","title":"P450-driven lipid metabolism and redox homeostasis","description":"The cluster centers on detoxification and redox balance alongside lipid/hormone biosynthesis, including prostaglandin, triglyceride, and calcitriol pathways, and omega-hydroxylase P450 activity. This points to cytochrome P450\u2013mediated metabolism of lipids and hormone precursors, with redox coupling; a few terms about sex differentiation and prostate growth suggest hormonal regulation rather than a single distinct function. Confidence: Medium","confidence":"Medium","size":14,"edges":80,"triangles":261,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":8},{"id":"GO:0001516","count":7},{"id":"GO:0006641","count":6},{"id":"GO:0045454","count":6},{"id":"GO:2000255","count":5}]},{"hash":"259498933126148837","title":"Central carbon metabolism and quinone biosynthesis","description":"This cluster shows strong signals from core energy pathways (glycolysis, TCA cycle, beta-oxidation) and various catabolic processes (valine, phenylacetate), plus biosynthesis of quinones (phylloquinone, menaquinone). It also includes terms tied to antibiotic biosynthesis and xenobiotic response, suggesting a microbial metabolic module that balances energy production with redox and detoxification functions. Overall, the proteins seem tied to central carbon metabolism complemented by quinone cofactor biosynthesis, justifying this label.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":10},{"id":"GO:0006635","count":9},{"id":"GO:0010124","count":9},{"id":"GO:0006574","count":9},{"id":"GO:0042372","count":9}]},{"hash":"443607645030186806","title":"Oxidative stress and inflammatory response","description":"The cluster is enriched for redox-related processes (glutathione metabolic process, cellular oxidant detoxification) and inflammatory signaling (prostaglandin biosynthesis, cellular response to lipopolysaccharide, regulation of leukocyte proliferation). This points to a functional module focused on managing oxidative stress while coordinating innate immune responses. Additional terms like nucleotide-excision repair and calcium-dependent signaling may reflect broader stress-response roles but do not define the core module as strongly.","confidence":"Medium","size":14,"edges":88,"triangles":331,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006749","count":13},{"id":"GO:0001516","count":13},{"id":"GO:2000469","count":12},{"id":"GO:0098869","count":12},{"id":"GO:0070664","count":12}]},{"hash":"1527186474403214256","title":"Cardiovascular development and calcineurin-NFAT signaling","description":"The top GO terms cluster around heart development, angiogenesis, and regulation of the calcineurin-NFAT signaling cascade, with a note of protein dephosphorylation. This points to a cohesive theme of cardiovascular development governed by phosphatase-mediated signaling, particularly the calcineurin-NFAT axis. Some peripheral terms (axonogenesis, meiosis cytokinesis, phospholipid transport) may be noise or broad annotations, but the core pattern supports a cardiovascular development and signaling focus.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032516","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0051531","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0035855","count":2}]},{"hash":"1776528751517099600","title":"ER-Golgi Vesicle Trafficking","description":"Most of the top GO terms describe vesicle transport between the ER and Golgi (ER-Golgi transport, COPII budding, retrograde transport), plus mRNA transport and ribosome biogenesis. The presence of actin nucleation regulation and GTPase activity suggests coordinated cytoskeletal control of trafficking. Taken together, the cluster is best captured by a label centered on ER-Golgi vesicle trafficking.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0050731","count":4},{"id":"GO:0006890","count":4},{"id":"GO:2000601","count":4},{"id":"GO:0000278","count":4}]},{"hash":"1027684250844382660","title":"Unknown","description":"The top GO terms cover diverse areas including muscle and brain development, various metabolic and replication-related processes, aging, and even a bacterial phenazine biosynthesis term, with no clear shared function across the cluster. This lack of a unifying theme suggests the proteins do not represent a cohesive biological module, so Unknown is appropriate.","confidence":"","size":14,"edges":30,"triangles":14,"max_degree":8,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0048741","count":4},{"id":"GO:0021762","count":4},{"id":"GO:0071320","count":4},{"id":"GO:0006602","count":4},{"id":"GO:1904524","count":4}]},{"hash":"1321382826544794265","title":"N-Terminal acetylation and amino-sugar metabolism","description":"These proteins show a clear enrichment for N-terminal modification processes, including N-terminal peptidyl-methionine acetylation, N-terminal peptidyl-glutamic acid acetylation, and N-terminal protein amino acid propionylation, suggesting a shared role in N-terminal modifications. They also prominently feature glucosamine/N-acetylglucosamine metabolic terms, pointing to amino-sugar metabolism. Other shared terms (ectoine and acetoin biosynthesis, melatonin biosynthetic process) indicate broader metabolic activity, but the recurring point is protein N-terminal acetylation and related modifications. The leaf formation regulation term appears as an outlier, likely due to broader functional annotations. Confidence: High","confidence":"","size":14,"edges":90,"triangles":352,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0019491","count":13},{"id":"GO:0030187","count":13},{"id":"GO:0017196","count":13},{"id":"GO:0045150","count":13},{"id":"GO:0018002","count":13}]},{"hash":"627136039369588269","title":"Mucosal immune signaling and ciliogenesis","description":"The cluster centers on immune-related processes (T cell differentiation and T cell receptor signaling, phagocytosis, host defense perturbation) alongside ciliogenesis and centriole assembly in multi-ciliated epithelial cells, suggesting a theme of mucosal immune function linked to epithelial differentiation; some terms (e.g., DNA integration) may be peripheral noise.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":2},{"id":"GO:0010387","count":1},{"id":"GO:0033089","count":1},{"id":"GO:0050862","count":1},{"id":"GO:0007099","count":1}]},{"hash":"1464932941471917952","title":"Golgi-ER vesicle trafficking and endocytosis","description":"The cluster is dominated by GO terms for Golgi localization and transport between the Golgi and ER, plus endocytosis and microtubule-based organelle movement, pointing to a coherent set of proteins involved in intracellular vesicle trafficking and protein targeting to Golgi/ER compartments.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000042","count":2},{"id":"GO:0006623","count":2},{"id":"GO:0006890","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0007286","count":2}]},{"hash":"639842927677383361","title":"Neuronal development and axon guidance","description":"The GO terms cluster around neural development and axon pathfinding, including pyramidal neuron development, trigeminal nerve organization, cerebellar granule cell precursor migration, and axon guidance modulation, indicating a cohesive theme of nervous system development.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050873","count":2},{"id":"GO:1901299","count":1},{"id":"GO:0006355","count":1},{"id":"GO:2000535","count":1},{"id":"GO:0021860","count":1}]},{"hash":"2269908630038361199","title":"Developmental gene regulation via chromatin modification","description":"The GO terms cluster around regulation of transcription and histone acetylation, with additional development-related terms like endodermal differentiation, sensory organ precursor fate, and imaginal disc fusion. This pattern supports the idea that these proteins function together in controlling developmental gene expression through chromatin modification, despite some obsolete terms. ","confidence":"Medium","size":14,"edges":15,"triangles":2,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0035987","count":1},{"id":"GO:0043981","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0045652","count":1},{"id":"GO:0043982","count":1}]},{"hash":"366268953819724702","title":"Unknown","description":"The terms span cell cycle, transcription, apoptosis, immune response, and diverse developmental processes with no clear unifying function, and even include obsolete GO terms. There isn\u2019t a coherent theme to assign a specific, representative label.","confidence":"","size":14,"edges":8,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":13},{"id":"GO:0006260","count":13},{"id":"GO:0007257","count":11},{"id":"GO:1903655","count":11},{"id":"GO:0097194","count":11}]},{"hash":"524787437029241410","title":"Glycosaminoglycan biosynthesis","description":"The cluster shows strong enrichment for glycosaminoglycan-related processes: heparan proteoglycan biosynthetic process, chondroitin sulfate biosynthetic process (even if obsolete terms are present), and N-acetylglucosamine metabolism, pointing to a core theme of GAG assembly and sulfation. Additional links to sulfate assimilation and related metabolic processes support this connective thread, though a few other metabolic terms appear as noise. Overall, a coherent GAG/proteoglycan biosynthesis function best represents the cluster.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0000103","count":14},{"id":"GO:0030210","count":14},{"id":"GO:0030206","count":14},{"id":"GO:0009812","count":14},{"id":"GO:0042403","count":14}]},{"hash":"678572604100580028","title":"SCF-mediated ubiquitin-dependent degradation and circadian regulation","description":"The top GO terms cluster around ubiquitin-dependent proteolysis and SCF-mediated ubiquitination, including protein polyubiquitination and SCF-dependent proteasomal degradation, indicating a core role in proteostasis. The presence of regulation of circadian rhythm alongside these ubiquitin-proteasome terms suggests the cluster links protein degradation to circadian timing. Additional terms related to DNA damage checkpoint signaling, synapse assembly, and stress responses (cadmium and oxidative stress) imply broader involvement in cellular stress and neural contexts, but the dominant theme remains ubiquitin-mediated degradation connected to circadian control.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0042752","count":5},{"id":"GO:0031146","count":4},{"id":"GO:1903378","count":3},{"id":"GO:0000209","count":3}]},{"hash":"600243913852334981","title":"Unknown","description":"The top GO terms are very diverse, spanning xenobiotic response, DNA replication, lung and lymphatic development, protein tetramerization, postsynaptic signaling and calcium regulation, unfolded protein response, and morphine response. With no clear single biological theme tying these terms together and no network edges among proteins, there isn\u2019t a coherent function for the cluster to label. ","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035690","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0030324","count":3},{"id":"GO:0051262","count":2},{"id":"GO:0060079","count":2}]},{"hash":"2109507935485861320","title":"Unknown","description":"The GO terms are scattered across host-symbiont interaction (symbiont entry into host cell, symbiont-mediated perturbation of host defenses), metal transport, stress response, translation, and cell-cycle processes, with no clear shared function tying all proteins together.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0030682","count":1},{"id":"GO:0015684","count":1},{"id":"GO:1901001","count":1},{"id":"GO:1903833","count":1}]},{"hash":"1551211089448258556","title":"Embryogenesis and apoptosis regulation","description":"The cluster's GO terms center on embryonic development processes (hindlimb morphogenesis, metanephros development, posterior head segmentation) and apoptosis-related activities (mitochondrial membrane permeability regulation, apoptotic process), with supporting roles in signaling (Wnt pathway) and metabolism (glucose import). This suggests a theme of developmental regulation intertwined with apoptosis, hence the label.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902108","count":2},{"id":"GO:0035289","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0007427","count":2},{"id":"GO:0046011","count":2}]},{"hash":"1368123756089218486","title":"DNA replication, transposition, and proviral integration","description":"This cluster is dominated by GO terms for DNA replication (GO:0006260), nucleotide-excision repair (GO:0006289), DNA transposition (GO:0006313), and DNA integration (GO:0015074), along with terms describing proviral latency and virus\u2013host entry (GO:0075732, GO:0075713, GO:0046718). Together these suggest proteins involved in genome manipulation and retroviral-like integration events, i.e., DNA replication/repair processes linked to proviral integration and viral genome incorporation. Confidence reflects a coherent theme across the terms, though some viral-entry related terms indicate broader host\u2013pathogen interaction aspects. ","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0006289","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2}]},{"hash":"1395106764909664091","title":"Neuropeptide Catabolism and Sensory Development","description":"The cluster centers on catabolic processing of several neuropeptides and peptide hormones (bradykinin, substance P, calcitonin, angiotensin maturation) while also including terms tied to sensory system development (ear development, pharyngeal system development, olfactory learning). This combination suggests a theme around regulation of peptide signaling and sensory organ maturation, justifying the chosen label.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002003","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0001921","count":1},{"id":"GO:0010815","count":1},{"id":"GO:0010814","count":1}]},{"hash":"1939718185561300815","title":"Unknown","description":"The top GO terms are diverse: DNA integration and transposition; glutathione metabolism; proteolysis; leukotriene biosynthesis; mitochondrial fission; protein oligomerization; dsRNA response; cell proliferation. No single process or function dominates, making it hard to define a concise, representative label. Therefore, Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0006750","count":1},{"id":"GO:0006508","count":1},{"id":"GO:0006751","count":1},{"id":"GO:1901750","count":1}]},{"hash":"2251206569980532787","title":"Embryonic development and morphogenesis","description":"These proteins are enriched for GO terms spanning broad embryonic development across multiple tissues\u2014endocrine system development, pancreatic islet formation, cartilage morphogenesis, EMT in heart cushion formation, left-right patterning, placental/trophoblast differentiation, mesoderm development, and palate formation\u2014reflecting a common theme of embryogenesis and tissue morphogenesis rather than a single pathway.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":11},{"id":"GO:0060806","count":11},{"id":"GO:0003323","count":11},{"id":"GO:0060536","count":11},{"id":"GO:0003198","count":11}]},{"hash":"1617012021525528604","title":"Sphingolipid metabolism and lipid signaling","description":"This cluster is dominated by sphingolipid-related metabolism (sphingosine, sphinganine-1-phosphate) and lipid signaling, with supporting terms for phospholipid turnover (phosphatidylglycerol biosynthesis, phospholipid dephosphorylation). While a few items (oxidant detoxification, glucose-6-phosphate transport, germ cell repulsion) are peripheral, the shared focus on lipid metabolism best explains the group.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044328","count":1},{"id":"GO:0044329","count":1},{"id":"GO:0098869","count":1},{"id":"GO:0006668","count":1},{"id":"GO:0006670","count":1}]},{"hash":"568028750799685920","title":"Neural development and axon guidance","description":"This cluster shows a clear emphasis on nervous system development and neuronal connectivity, with terms like nervous system development, axon midline choice point recognition, and ionotropic glutamate receptor signaling, plus collateral sprouting, suggesting roles in axon guidance and synaptic formation. Other terms relate to neuronal signaling and morphology, supporting a neural-focused functional theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":2},{"id":"GO:0006821","count":1},{"id":"GO:0051563","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0060670","count":1}]},{"hash":"282905999928460824","title":"Bone, Cartilage, and Heart Development","description":"The prevalent terms describe bone/cartilage differentiation and growth (chondrocyte/chondroblast differentiation, osteoblast proliferation) and heart development (atrial septum morphogenesis) with vascular context (endothelial cell chemotaxis). A few unrelated terms are present, but the overall theme is skeletal and cardiac development.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":3},{"id":"GO:0007166","count":1},{"id":"GO:0046676","count":1},{"id":"GO:0061484","count":1},{"id":"GO:0002062","count":1}]},{"hash":"38915002227944717","title":"Ribosome biogenesis and ubiquitin-regulated mitosis","description":"This cluster centers on ribosome biogenesis and mitotic cell cycle processes, with multiple ubiquitin-related pathways (autoubiquitination, SCF-dependent degradation, K11-linked ubiquitination) suggesting coordinated regulation of ribosome production and proteostasis during cell division, plus rRNA maturation components.","confidence":"High","size":13,"edges":66,"triangles":202,"max_degree":12,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0006378","count":4},{"id":"GO:1901407","count":4},{"id":"GO:0000278","count":4}]},{"hash":"1750973397772956023","title":"P450-Mediated Lipid Metabolism","description":"The terms point to lipid pathways governed by cytochrome P450 enzymes: omega-hydroxylation and epoxygenation, prostaglandin and calcitriol biosynthesis, and triglyceride metabolism, with reproductive development signals (sex differentiation). This suggests a cohesive theme of lipid metabolism and P450 signaling; a few terms (vancomycin biosynthetic process, maternal process involved in parturition) appear less connected.","confidence":"Medium","size":13,"edges":26,"triangles":23,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060736","count":10},{"id":"GO:0033072","count":10},{"id":"GO:0036378","count":10},{"id":"GO:0097267","count":10},{"id":"GO:0006641","count":10}]},{"hash":"599423934528667640","title":"Embryonic development and organ morphogenesis","description":"This cluster shows proteins associated with broad embryonic development and tissue morphogenesis, including placenta and pancreatic development, cartilage morphogenesis, EMT in heart development, left-right patterning, and neuronal migration. The recurring theme is differentiation and formation of organs during embryogenesis, with some regulatory processes noted (e.g., RNA polymerase II regulation, CDK activity). Confidence: High","confidence":"","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0003198","count":5}]},{"hash":"1508692017208782279","title":"Heat-stress Protein Quality Control","description":"This cluster is enriched for terms related to heat response, unfolded protein handling, ERAD, and redox balance, pointing to a module that maintains proteome integrity under heat stress through chaperone activity and degradation pathways; while a few terms (DNA replication, tRNA import) are less central, the dominant theme is protein quality control during heat exposure.","confidence":"Medium","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0045454","count":4},{"id":"GO:0035719","count":4},{"id":"GO:0051259","count":4}]},{"hash":"471490921529371435","title":"Auditory neuronal signaling and cochlear development","description":"This cluster is dominated by terms tied to neural activity and hearing: calcium ion import, membrane depolarization, excitatory and inhibitory postsynaptic potentials, cochlea development, and detection of sound. While a couple terms are broader (amyloid fibril regulation, neuron survival, cocaine response), the core theme centers on neuronal excitability and auditory function.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":6},{"id":"GO:0051899","count":5},{"id":"GO:1905906","count":5},{"id":"GO:0060080","count":5},{"id":"GO:0060079","count":5}]},{"hash":"2273478731950350322","title":"Protein quality control and stress response","description":"The top GO terms point to proteostasis processes\u2014ubiquitin-dependent protein catabolic process and response to unfolded protein\u2014indicating a cluster centered on protein folding/degradation and cellular stress response. A few terms (snoRNP assembly, mitotic regulation, morphine response, fat pad development) appear peripheral or outdated, suggesting annotation noise, but the core theme remains proteostasis-related.","confidence":"Medium","size":13,"edges":12,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0035435","count":3},{"id":"GO:0042787","count":2},{"id":"GO:1901215","count":2},{"id":"GO:0035955","count":2},{"id":"GO:0043278","count":2}]},{"hash":"437599091215742666","title":"Neurotransmitter transport and synaptic signaling","description":"The top GO terms point to uptake and transport of neurotransmitters (dopamine, serotonin, taurine), along with glycinergic synaptic transmission and regulation of synaptic activity, plus a note on thalamus development. This pattern suggests a cohesive theme of neural communication and neurotransmitter handling in synapses, justifying a label focused on neurotransmitter transport and synaptic signaling. ","confidence":"Medium","size":13,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0015824","count":1},{"id":"GO:1905847","count":1},{"id":"GO:0051583","count":1},{"id":"GO:0014064","count":1},{"id":"GO:0060092","count":1}]},{"hash":"2281071610871795760","title":"Unknown","description":"Top terms include ribosome assembly and translation, plus diverse skeletal development terms (osteoblast fate, odontogenesis, chondrocyte differentiation, forelimb morphogenesis, TGF-beta/FGF signaling). The absence of a unifying function and lack of interactions suggests no coherent cluster function can be inferred; so Unknown with None.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000027","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0002051","count":1},{"id":"GO:0042487","count":1}]},{"hash":"2023393700290283637","title":"Ribosome biogenesis and translation","description":"Most top GO terms relate to ribosome assembly and function: ribosome biogenesis, maturation of SSU/LSU rRNA, and translation steps (initiation, termination). This cohesiveness points to a cluster of proteins involved in making ribosomes and carrying out protein synthesis. A few terms about antibiotic response and non-stop decay are less central but may reflect stress responses linked to translation quality control.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:0000463","count":3},{"id":"GO:0006415","count":2},{"id":"GO:0006413","count":2},{"id":"GO:0000462","count":2}]},{"hash":"796844066537057595","title":"Ribosome biogenesis and cell division","description":"The cluster is dominated by GO terms for ribosome biogenesis, translation, and cell cycle processes (ribosome assembly, protein synthesis, cell division, mitotic cohesion). This points to a core functional module of ribosome formation coupled to cell proliferation. The development terms appear as contextual roles rather than defining the core function, so the central theme remains protein synthesis machinery and cell division.","confidence":"Medium","size":13,"edges":38,"triangles":49,"max_degree":11,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0000463","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0000747","count":3}]},{"hash":"1837238819593296625","title":"Membrane Transporters","description":"The cluster is dominated by multiple transmembrane transport GO terms for diverse substrates (myo-inositol, pantothenate, biotin, glucose) and a sodium export term, suggesting a shared function in membrane transport; the other terms (proteasome assembly, transcription, filamentous growth, DNA maintenance) are less frequent and may reflect incidental annotations or multifunctionality, but do not override the transport-focused theme.","confidence":"High","size":13,"edges":9,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0015798","count":2},{"id":"GO:0015887","count":2},{"id":"GO:0008292","count":2},{"id":"GO:0071436","count":2},{"id":"GO:0015878","count":2}]},{"hash":"1920055439223137713","title":"Amino acid and small solute membrane transport","description":"The Top Terms show multiple transmembrane transport processes for amino acids (methionine, lysine, leucine, D-alanine), GABA, carnitine, and ammonium, plus general transmembrane transport and osmotic response. This clustering clearly points to membrane transport proteins that move amino acids and related small solutes across the plasma membrane, with some osmotic regulation context.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044690","count":3},{"id":"GO:0097639","count":3},{"id":"GO:0035826","count":3},{"id":"GO:0098713","count":3},{"id":"GO:1902274","count":3}]},{"hash":"1010520499357040671","title":"Neural development and GABAergic synaptic transmission","description":"The top GO terms strongly point to neuronal development and synaptic function: hippocampus development, neural tube patterning, photoreceptor development, and GABAergic synaptic transmission, with neuron-specific apoptosis regulation reinforcing a neuronal theme. Although some terms touch on general cellular processes (Golgi/nuclear envelope organization) or non-neuronal activities (mast cell chemotaxis, podosome assembly), they seem secondary to the dominant neural development signal. Confidence: Medium","confidence":"","size":13,"edges":34,"triangles":38,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043525","count":10},{"id":"GO:0021766","count":10},{"id":"GO:0051932","count":9},{"id":"GO:0007030","count":9},{"id":"GO:0021532","count":9}]},{"hash":"1577437234792530147","title":"P450-driven lipid metabolism and hormone signaling","description":"The GO terms cluster around lipid-derived signaling and hormone-related processes, including omega-hydroxylase and epoxygenase P450 pathways, prostaglandin and calcitriol biosynthesis, triglyceride metabolism, and reproductive development terms (prostate gland growth, sex differentiation, parturition). This suggests a coherent theme of P450-mediated lipid metabolism and hormone signaling, with a possible outlier term related to antibiotic biosynthesis that does not define the cluster\u2019s core function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060736","count":13},{"id":"GO:0033072","count":13},{"id":"GO:0036378","count":13},{"id":"GO:0097267","count":13},{"id":"GO:0006641","count":13}]},{"hash":"785559299431574078","title":"Neuronal Sensory Signaling","description":"The cluster includes sensory modalities (pain, vision) along with neuronal signaling processes (membrane potential regulation, protein phosphorylation) and responses to stimuli such as temperature and morphine, suggesting a cohesive theme of neural sensing and signal transduction; a few peripheral terms (LPS response, saliva secretion) may reflect multifunctional proteins within the group.","confidence":"Medium","size":13,"edges":47,"triangles":68,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0002024","count":6},{"id":"GO:0071502","count":6},{"id":"GO:0032496","count":5},{"id":"GO:0007596","count":5}]},{"hash":"488582915729539038","title":"Mitochondrial lipid biosynthesis and remodeling","description":"The top GO terms cluster around lipid biosynthesis and mitochondrial membrane processes: cardiolipin acyl-chain remodeling, CDP-diacylglycerol biosynthesis, ether lipid biosynthetic process, and phosphatidylcholine biosynthesis, together with mitochondrial ATP synthesis. This points to a common theme of mitochondrial membrane lipid metabolism, with some auxiliary terms reflecting broader cellular development or signaling. ","confidence":"Medium","size":13,"edges":9,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0042775","count":2},{"id":"GO:2001246","count":2},{"id":"GO:0010143","count":2},{"id":"GO:0021587","count":2}]},{"hash":"1520324696248978651","title":"Transmembrane Ion Transporters","description":"The top GO terms are dominated by various membrane transport activities (sodium and potassium ion transport, arsenite transport, regulation of phosphate transmembrane transport) and general transmembrane transport, pointing to a cluster of proteins likely functioning as membrane transporters or transport regulators. Some terms relate to membrane organization or adhesion, and a few are unrelated (e.g., DNA replication), suggesting additional but non-central roles. Confidence: Medium","confidence":"","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0015700","count":4},{"id":"GO:0006814","count":4},{"id":"GO:2000185","count":4},{"id":"GO:0006813","count":4},{"id":"GO:0055085","count":4}]},{"hash":"1475957157146796929","title":"Keratinocyte differentiation and growth control signaling","description":"This cluster centers on epithelial cell fate regulation, with prominent terms for keratinocyte differentiation and signaling pathways that control proliferation and growth (Hippo and Wnt), along with apoptosis and DNA replication initiation, suggesting a cohesive theme of skin cell differentiation and growth control.","confidence":"High","size":13,"edges":22,"triangles":10,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046827","count":10},{"id":"GO:0006915","count":10},{"id":"GO:0032298","count":10},{"id":"GO:0060044","count":10},{"id":"GO:0090263","count":10}]},{"hash":"1623401398523847725","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":49,"triangles":90,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":9},{"id":"GO:0007601","count":9},{"id":"GO:0043547","count":8},{"id":"GO:1905869","count":7},{"id":"GO:0031291","count":7}]},{"hash":"1244806327319514274","title":"Insect CNS and sensory organ development","description":"The cluster shows terms tied to nervous system formation and patterning of sensory organs (central nervous system formation, segment specification, antennal and compound eye development) as well as related muscle development, pointing to a cohesive theme of insect developmental patterning and organogenesis. A few outlier terms (obsolete annotations, metabolism, inflammatory cytokine production) are present but do not override the core developmental signal.","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:1903212","count":1},{"id":"GO:0021556","count":1},{"id":"GO:0007379","count":1},{"id":"GO:0007469","count":1},{"id":"GO:1902064","count":1}]},{"hash":"1327794914669360062","title":"Transmembrane ion and metabolite transport","description":"Dominant GO terms are various transmembrane transports, including Na+, K+, and metabolite transport (malate, succinate, citrate) plus a general transmembrane transport term. This pattern points to a cluster of membrane transport proteins with diverse substrates; the occasional myelin assembly term appears as a minor outlier. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0015743","count":3},{"id":"GO:0015700","count":3},{"id":"GO:0015744","count":3},{"id":"GO:0098656","count":3},{"id":"GO:0006814","count":3}]},{"hash":"1742948255620615172","title":"Unknown","description":"The top GO terms are disparate (regulation of protein complex stability; positive regulation of macroautophagy; DNA transposition; obsolete nucleic acid phosphodiester bond hydrolysis) and there are no edges or cohesive pathway connections, so there is no clear shared function tying these proteins together. Therefore, a specific functional label cannot be confidently assigned.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061635","count":1},{"id":"GO:0016239","count":1},{"id":"GO:0090305","count":1},{"id":"GO:0006313","count":1}]},{"hash":"2117214207515719633","title":"Embryonic Development and Organ Morphogenesis","description":"The GO terms cluster around embryonic development and the formation of organs/tissues across multiple lineages (placenta, pancreas, cartilage, heart structures, facial formation, and digestive tract). This suggests a coherent theme of organogenesis and morphogenesis during embryogenesis, rather than a single signaling or metabolic pathway.","confidence":"High","size":13,"edges":13,"triangles":1,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":9},{"id":"GO:0060806","count":9},{"id":"GO:0003323","count":9},{"id":"GO:0060536","count":9},{"id":"GO:0003198","count":9}]},{"hash":"1164893053629168992","title":"Membrane Transporters of Small Molecules","description":"This cluster is dominated by GO terms for transporting diverse small molecules across membranes, including carbohydrates, branched-chain amino acids, taurine, monoatomic anions, xenobiotics, and long-chain fatty acids into peroxisomes, pointing to a transporter-focused function. A few outlier terms (DNA transposition, MHC class I antigen processing, cytochrome complex assembly) are present but do not align with the primary theme, so the transport-focused label remains most representative.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0046618","count":2},{"id":"GO:0008643","count":2},{"id":"GO:0015803","count":2},{"id":"GO:0019885","count":2}]},{"hash":"1462690772731131233","title":"Broad metabolic biosynthesis and stress response","description":"Most frequent GO terms cluster around biosynthetic processes for several metabolites (polyamine, biotin, ubiquinone, antibiotics) and a catabolic process for triglycerides, plus protein processing steps (mRNA capping, N-terminal dimethylation). The presence of stress-related terms (hyperosmotic response, cellular senescence, response to cocaine) suggests involvement in general metabolic regulation and cellular stress responses rather than a single cohesive pathway. Therefore, a broad label capturing both metabolism and stress response is appropriate.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006596","count":5},{"id":"GO:0009102","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0019433","count":4},{"id":"GO:0006370","count":3}]},{"hash":"231495070383365663","title":"Proviral integration and retrotransposition","description":"Based on the GO terms, the cluster centers on integration of genetic material into the host genome, including proviral latency, DNA transposition, and retrotransposition, alongside entries related to viral entry/release. This points to processes of viral integration and mobile genetic element activity (transposons/retrotransposons) and their impact on host transcription, justifying a label focused on proviral integration and retrotransposition.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":5},{"id":"GO:0075732","count":5},{"id":"GO:0075713","count":5},{"id":"GO:0039651","count":5},{"id":"GO:0015074","count":5}]},{"hash":"1955103932775095612","title":"Peptide Hormone Processing and Receptor Recycling","description":"The terms point to processing and turnover of peptide hormones (bradykinin, substance P, calcitonin, angiotensin) and related receptor trafficking, suggesting a theme of peptide hormone maturation and receptor recycling. Some environmental/developmental terms (olfactory learning, ear/pharyngeal development) appear as outliers, but the core signal is peptide hormone catabolism and receptor turnover.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0090305","count":3},{"id":"GO:0001921","count":3},{"id":"GO:0010815","count":3},{"id":"GO:0010814","count":3},{"id":"GO:0008355","count":3}]},{"hash":"297249389543694056","title":"Viral entry and proviral latency","description":"The strongest, recurring themes in the top GO terms are processes related to viruses entering host cells, penetrating the host nucleus, and establishing integrated proviral latency via DNA integration. These collectively point to virus\u2013host interactions and genome integration as the central motif of this cluster. Some other terms (e.g., lipid metabolism or general translation-related terms) may be incidental or reflect broader cellular processes, but they do not outweigh the viral integration theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":3},{"id":"GO:0045444","count":2},{"id":"GO:0010745","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2}]},{"hash":"854974439080215671","title":"GTPase-regulated cell migration signaling","description":"Based on the top GO terms, the cluster shows enrichment for regulation of Ras and other GTPases, lamellipodium assembly, and cell migration, together with GPCR/thrombin receptor signaling. This points to a coherent theme of cytoskeletal remodeling and motility driven by GTPase activity and receptor signaling. Some terms (neutrophil degranulation, acrosome reaction) are tangential, and a few entries are obsolete, but the core pattern supports a GTPase-regulated migration/signal transduction theme.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":2},{"id":"GO:0046580","count":2},{"id":"GO:0030032","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0043314","count":2}]},{"hash":"1046065430573834687","title":"Cell cycle, ribosome biogenesis, and development","description":"The dominant terms center on mitotic cell cycle and chromatid cohesion, combined with ribosome biogenesis, indicating robust proliferation with active protein synthesis. Developmental processes (embryonic organ and skin development) further align with growth and tissue formation, while glucose signaling and GTPase regulation suggest growth control. Some terms are peripheral (cytokine production, RNA branch site recognition) and do not define the core function. Overall, the cluster appears to reflect proliferation linked to developmental processes.","confidence":"Medium","size":12,"edges":36,"triangles":59,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0043981","count":4},{"id":"GO:0007064","count":4}]},{"hash":"953135166794650587","title":"Innate Immune Activation and Inflammation","description":"The cluster is driven by GO terms related to innate immune responses and inflammation, including defense against Gram-positive bacteria, cellular response to LPS, GM-CSF signaling, and type IV hypersensitivity, with apoptosis execution also appearing. Although a few terms touch on development or epigenetic regulation, the strongest shared theme is immune activation and inflammatory signaling, suggesting these proteins participate in innate immunity and related cell fate decisions.","confidence":"Medium","size":12,"edges":14,"triangles":16,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007100","count":7},{"id":"GO:0001502","count":7},{"id":"GO:0050830","count":7},{"id":"GO:0044027","count":7},{"id":"GO:0097011","count":7}]},{"hash":"260019719257154926","title":"Membrane Transporters for Metabolites and Xenobiotics","description":"This cluster is dominated by diverse transmembrane transport GO terms, including vitamin, xenobiotic, glucose, nitrite, nitrate, and sodium ion transport, plus a related osmotic stress response; together these point to a coherent theme of membrane transporter activity handling nutrients, metabolites, and foreign compounds.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0006970","count":2},{"id":"GO:0046677","count":2},{"id":"GO:1904659","count":2}]},{"hash":"1750363200854890786","title":"Spliceosome-mediated mRNA processing and regulation","description":"Based on frequent GO terms such as mRNA cis splicing via spliceosome; regulation of mRNA splicing via spliceosome (positive and negative); regulation of alternative splicing; and regulation of mRNA polyadenylation, the cluster appears centered on spliceosome-driven RNA processing and its regulation. Additional terms like mRNA stability in response to stress and IRES-dependent translation reflect broader post-transcriptional control, but the spliceosome-related terms are dominant.","confidence":"High","size":12,"edges":65,"triangles":210,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":9},{"id":"GO:0010610","count":9},{"id":"GO:0048025","count":9},{"id":"GO:1900363","count":8},{"id":"GO:0000381","count":8}]},{"hash":"1213799477881681186","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":14,"triangles":3,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":9},{"id":"GO:0006260","count":9},{"id":"GO:0090394","count":8},{"id":"GO:0071035","count":8},{"id":"GO:0000393","count":8}]},{"hash":"1298754173888314853","title":"Auditory Neural Signaling and Cochlear Development","description":"This cluster's terms are dominated by neural signaling and auditory/sensory processes: membrane depolarization, inhibitory/excitatory postsynaptic potentials, transmission and regulation of nerve impulses, cochlea development, and detection of sound. The cocaine response term aligns with CNS neurotransmission, while amyloid fibril regulation is less specific. Overall, the theme points to auditory neural signaling and cochlear development.","confidence":"High","size":12,"edges":29,"triangles":24,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":8},{"id":"GO:0048630","count":8},{"id":"GO:0051899","count":7},{"id":"GO:1905906","count":7},{"id":"GO:0060080","count":7}]},{"hash":"713077648145714662","title":"Metabolic biosynthesis and metal stress response","description":"GO terms indicate multiple biosynthetic processes (NAD+ and polyamine biosynthesis, lipoprotein biosynthesis) and oxaloacetate metabolism, plus a cadmium ion response. This suggests a cluster centered on broad metabolic biosynthesis with an accompanying metal-stress response, rather than a single, cohesive pathway.","confidence":"Medium","size":12,"edges":13,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0009435","count":3},{"id":"GO:0006596","count":3},{"id":"GO:0006107","count":3},{"id":"GO:0046686","count":3},{"id":"GO:0042158","count":3}]},{"hash":"1226801184073296206","title":"Drosophila imaginal disc development and photoreceptor morphogenesis","description":"The GO terms cluster around developmental programs in Drosophila imaginal discs (antenna and wing structures, and eye photoreceptors), including polarity establishment and actin/cytoskeletal organization, with transcriptional regulation being a common underlying theme. This suggests a cohesive theme of imaginal-disc\u2013driven morphogenesis and its transcriptional control.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0006355","count":1},{"id":"GO:0007469","count":1},{"id":"GO:0045316","count":1},{"id":"GO:0051491","count":1}]},{"hash":"617363098038431717","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010587","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0000398","count":2}]},{"hash":"2052400632113237290","title":"Unknown","description":"The terms cover multiple, seemingly unrelated areas (lithium and corticosterone response, cold response, fungicide exposure, redox and glutathione metabolism, nitrate assimilation, thymidine catabolic process, spliceosome conformational change). The lack of a unifying function among proteins suggests no cohesive biological theme can be assigned.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010226","count":2},{"id":"GO:0000388","count":2},{"id":"GO:0051412","count":1},{"id":"GO:0042128","count":1},{"id":"GO:0045454","count":1}]},{"hash":"3413758611799162","title":"Sugar and Ion Transmembrane Transporters","description":"The cluster's top GO terms are dominated by transmembrane transport across membranes for multiple substrates (sugars, ions, vitamins, and neurotransmitter loading), suggesting a transport-centric group of proteins; some terms like nitrate assimilation add metabolism context but overall the theme is membrane transport.","confidence":"High","size":12,"edges":11,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1902600","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0006004","count":2},{"id":"GO:0035461","count":2}]},{"hash":"441065012490494349","title":"Unknown","description":"The listed GO terms cover several distinct processes (cardiovascular/endocrine regulation, cartilage differentiation, immune signaling, coagulation, and basic energy metabolism) with no clear, shared function tying the proteins together, so a cohesive and specific label cannot be derived.","confidence":"","size":12,"edges":53,"triangles":117,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0045777","count":3},{"id":"GO:0002062","count":2},{"id":"GO:0030325","count":2},{"id":"GO:0048144","count":2},{"id":"GO:0070245","count":2}]},{"hash":"1352322239565620751","title":"SNARE-driven neuronal vesicle trafficking and exocytosis","description":"The cluster centers on vesicle trafficking between the ER/Golgi and synaptic compartments, SNARE complex assembly, and synaptic vesicle fusion, with terms linking Golgi transport to neurotransmitter release and synaptic potentiation. This suggests a cohesive function in neuronal vesicle trafficking and SNARE-mediated exocytosis, spanning early secretory pathways to synaptic transmission.","confidence":"High","size":12,"edges":25,"triangles":16,"max_degree":8,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048280","count":9},{"id":"GO:0006888","count":8},{"id":"GO:0090161","count":8},{"id":"GO:0006891","count":8},{"id":"GO:0035493","count":7}]},{"hash":"948201053666071891","title":"Kinase signaling and transcription regulation","description":"The proteins cluster around phosphorylation-driven signaling and transcription control, with GO terms for DNA-templated transcription, activation of protein kinase activity, positive regulation of GTPase activity, MAP kinase modulation, and tachykinin receptor signaling. While a few terms touch on development or DNA repair, the common theme is kinase- and GPCR-mediated signaling that can influence transcription and downstream cellular processes.","confidence":"Medium","size":12,"edges":10,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0032147","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0001824","count":1},{"id":"GO:1902064","count":1}]},{"hash":"84878199130795179","title":"Ciliogenesis and developmental signaling","description":"Most of the top GO terms point to cilium-related processes (motile and non-motile cilium assembly, epithelial cilium movement) and to developmentally important pathways (eye photoreceptor development, Hedgehog signaling via Smoothened, heart looping). This suggests the cluster represents proteins involved in cilium formation and cilia-mediated developmental signaling. A few terms like DNA transposition and apoptosis are less central but do not negate the prevailing ciliary/development theme.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0001935","count":2},{"id":"GO:0042462","count":1},{"id":"GO:0003351","count":1},{"id":"GO:0044458","count":1}]},{"hash":"1415590445489689348","title":"Ribosome Biogenesis and rRNA Processing","description":"The top terms largely point to ribosome assembly and rRNA maturation/export, notably ribosome biogenesis (GO:0042254), maturation of LSU rRNA (GO:0000463), and export of the large subunit (GO:0000055). These indicate a shared function in ribosome assembly and rRNA processing, despite a few obsolete or unrelated terms in the list that may reflect older annotations. Confidence: Medium","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010971","count":1},{"id":"GO:0000463","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0042254","count":1},{"id":"GO:1901857","count":1}]},{"hash":"1319921127698034501","title":"Sphingolipid metabolism and keratinocyte differentiation","description":"The top GO terms point to sphingolipid pathways (ceramide catabolic process, sphingosine biosynthetic process) and keratinocyte differentiation, suggesting a theme where sphingolipid metabolism influences epidermal cell fate. Additional terms related to cell-matrix adhesion and calcium signaling fit within the skin biology context, reinforcing a cohesive sphingolipid\u2013keratinocyte function cluster.","confidence":"Medium","size":12,"edges":16,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045047","count":1},{"id":"GO:0006465","count":1},{"id":"GO:0046514","count":1},{"id":"GO:0033629","count":1},{"id":"GO:0001953","count":1}]},{"hash":"142089642258214275","title":"Motor neuron migration and axon guidance","description":"The cluster is enriched for neuron-related processes, including lateral motor column neuron migration, motor neuron axon guidance regulation, and axon guidance (anterior/posterior) with associated axon extension and cell\u2013matrix adhesion, indicating a cohesive theme around neuronal development and pathfinding. Some development terms like hair follicle and podocyte development appear as minor associations, but the dominant signal centers on motor neuron migration and axon guidance.","confidence":"High","size":12,"edges":63,"triangles":192,"max_degree":11,"top_function":"wound healing","top_go_terms":[{"id":"GO:0097477","count":6},{"id":"GO:0070527","count":6},{"id":"GO:0007160","count":5},{"id":"GO:0050873","count":4},{"id":"GO:1905812","count":4}]},{"hash":"186900396232490428","title":"N-terminal acetylation and related acylations","description":"These proteins are enriched for GO terms about N-terminal protein modifications (N-terminal acetylation, peptidyl-Met/Glu acetylation, and N-terminal propionylation), suggesting a common theme of N-terminal post-translational modification. Other terms point to surrounding metabolic contexts (glucosamine/N-acetylglucosamine metabolism) and plant development, but the clearest thread is the acetylation/acylation theme.","confidence":"Medium","size":12,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019491","count":6},{"id":"GO:0030187","count":6},{"id":"GO:0017196","count":6},{"id":"GO:0045150","count":6},{"id":"GO:0018002","count":6}]},{"hash":"346162917773675168","title":"Neuronal development and axonal sodium-channel clustering","description":"This cluster centers on neural development and axonal organization, highlighted by CNS development and embryonic morphogenesis terms, nerve impulse transmission, and specific processes like clustering of voltage-gated sodium channels and localization to the juxtaparanode region of the axon. The presence of apoptotic and immune-type hypersensitivity terms appears peripheral, not defining the main theme, which is neural development and ion-channel\u2013mediated signaling.","confidence":"High","size":12,"edges":36,"triangles":32,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0007417","count":3},{"id":"GO:0008284","count":3},{"id":"GO:0045162","count":3},{"id":"GO:0019226","count":2}]},{"hash":"441362437313486500","title":"DNA Transposition and Proviral Integration","description":"Dominant GO terms are DNA transposition, DNA integration, and establishment of integrated proviral latency, indicating a set of proteins linked to mobile genetic element activity and provirus integration. A few unrelated terms (apoptosis, mast cell chemotaxis, Golgi organization, GABAergic transmission) may reflect annotation noise or multi-function proteins, but the core signal supports a mobility/integration theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0051932","count":1}]},{"hash":"1147775103196232141","title":"Unknown","description":"The GO terms span diverse processes (immune cell differentiation, metabolism, chromatin remodeling, stress/response pathways) with no single cohesive function linking the proteins, and the cluster shows no network connectivity, so there is no clear representative theme.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0019835","count":2},{"id":"GO:0005987","count":2},{"id":"GO:0030851","count":2},{"id":"GO:0043044","count":2}]},{"hash":"1795167682796954041","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0000453","count":1},{"id":"GO:0002938","count":1},{"id":"GO:0007159","count":1}]},{"hash":"1837814144579788475","title":"Calcium-NFAT neural and muscle development","description":"The GO terms cluster around calcium signaling via the calcineurin-NFAT pathway, including regulation of postsynaptic calcium and excitatory synaptic activity, as well as developmental processes in the nervous system (peripheral myelination, substantia nigra development) and skeletal muscle fiber development. EMT appears as a less central term but may reflect broader developmental remodeling. Overall, the common thread is calcium- and NFAT-dependent signaling guiding neural and muscle development.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022011","count":4},{"id":"GO:0060079","count":3},{"id":"GO:0099566","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0001837","count":3}]},{"hash":"1318717987746795894","title":"Neurovascular signaling and plasticity","description":"The top GO terms point to neural signaling and synaptic plasticity (short-term memory, long-term potentiation, EPSP) alongside vascular processes (angiogenesis, endothelial migration, heart rate regulation) and mitochondrial calcium import, suggesting a coordinated theme of neurovascular communication and activity-dependent regulation. Immune and transcription regulatory hints are present but appear ancillary to the core theme.","confidence":"Medium","size":12,"edges":18,"triangles":8,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0002027","count":5},{"id":"GO:0036444","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0007614","count":5},{"id":"GO:0060291","count":5}]},{"hash":"1959049198986622016","title":"Ubiquitin-Dependent Regulation and NF-kappaB Signaling","description":"Most of the top terms center on ubiquitination and ubiquitin-mediated proteolysis (ubiquitin-dependent protein catabolic process, polyubiquitination, K48-linked ubiquitination, histone ubiquitination), with several terms tying to NF-kappaB pathway activation (IKK activity, I-kappaB phosphorylation). This suggests a theme of ubiquitin-driven protein turnover and signaling that feeds into NF-kappaB regulation, though a few terms (peroxisome import, histone acetylation regulation) are less cohesive with the main pattern.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":1},{"id":"GO:0070535","count":1},{"id":"GO:2000620","count":1},{"id":"GO:0007250","count":1},{"id":"GO:0051865","count":1}]},{"hash":"760821509929762948","title":"Viral entry and proviral genome integration","description":"The terms strongly emphasize viral/symbiont entry into host cells, nuclear penetration, proviral latency, and DNA integration, with supporting processes like RNA-templated DNA biosynthesis and DNA replication/recombination, and even suppression of siRNA processing, pointing to a cohesive theme of viral genome integration and host interaction.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0039651","count":2}]},{"hash":"1019498648658933881","title":"Insect Developmental Signaling and Vision","description":"The terms point to insect-specific development (larval cuticle, heart) and sensory/visual signaling (visual perception, opsin signaling) with common signaling processes (phosphorylation, GTPase activity, calcium release), suggesting a cluster of proteins coordinating development with sensory signaling in insects rather than a single canonical pathway.","confidence":"Medium","size":11,"edges":21,"triangles":5,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:1903087","count":2},{"id":"GO:0006468","count":2},{"id":"GO:0022400","count":2},{"id":"GO:0043950","count":2}]},{"hash":"808496961563042353","title":"Lung morphogenesis and surfactant homeostasis","description":"This cluster is dominated by GO terms related to lung branching morphogenesis and epithelial tube branching (lung development) as well as surfactant homeostasis, indicating a coherent theme of lung development and function; a few unrelated terms are present but do not define the cluster.","confidence":"Medium","size":11,"edges":9,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0060448","count":1},{"id":"GO:0010815","count":1},{"id":"GO:0034769","count":1},{"id":"GO:2000179","count":1},{"id":"GO:0045453","count":1}]},{"hash":"2099155856171339918","title":"Immune and Stress Response Regulators","description":"The top GO terms cluster around responses to stress and immune stimuli (e.g., response to immobilization stress; cellular response to lipopolysaccharide) and encompass regulatory roles across diverse pathways (positive/negative regulation of various biosynthetic and cellular processes). This pattern suggests the proteins function primarily as modulators of immune and stress signaling rather than as enzymes in a single pathway. Confidence: Medium","confidence":"","size":11,"edges":9,"triangles":1,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0035902","count":4},{"id":"GO:1903208","count":2},{"id":"GO:0032331","count":2},{"id":"GO:0050680","count":2},{"id":"GO:0071222","count":2}]},{"hash":"2178163031201808236","title":"Spliceosome and mRNA processing factors","description":"The cluster is dominated by terms related to mRNA splicing via the spliceosome, snRNP and spliceosomal complex assembly, and broader RNA processing including deadenylation-dependent decapping, nuclear import, and P-body assembly, indicating a cohesive group of spliceosome and RNA metabolism proteins (with some cell-cycle/regulatory connections reflected by G0 to G1 and hair cycle terms).","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0045292","count":6},{"id":"GO:0048025","count":5},{"id":"GO:0000290","count":5},{"id":"GO:0070317","count":5},{"id":"GO:0051170","count":5}]},{"hash":"1101069136230014805","title":"Dopaminergic neuron development and cellular stress","description":"The cluster centers on midbrain dopaminergic neuron differentiation, suggesting a neuronal development theme. Co-occurring terms for proteostasis (ubiquitin-dependent proteolysis), nuclear transport regulation, redox homeostasis, and glucocorticoid signaling point to cellular stress and quality-control processes accompanying neuron maturation, with additional signals for immune response and cell proliferation control reflecting broader regulatory context. Overall, it appears to reflect dopaminergic neuron development intertwined with stress and protein homeostasis mechanisms.","confidence":"Medium","size":11,"edges":20,"triangles":6,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":3},{"id":"GO:0046825","count":3},{"id":"GO:1904948","count":2},{"id":"GO:0051301","count":2},{"id":"GO:2000324","count":2}]},{"hash":"1113889893063827011","title":"Nematode development, molting, and reproduction","description":"The GO terms point to nematode-specific developmental and reproductive processes (molting cycle and cuticle formation, nematode pharyngeal pumping, maternal specification of dorsal/ventral axis, polyspermy prevention, embryonic morphogenesis), with supporting general protein processing/trafficking terms. This suggests a coherent theme around nematode development and reproduction rather than a single universal cellular process.","confidence":"High","size":11,"edges":8,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0018230","count":1},{"id":"GO:0006612","count":1},{"id":"GO:0043001","count":1},{"id":"GO:0006508","count":1},{"id":"GO:0018996","count":1}]},{"hash":"595929656749356405","title":"Embryonic organogenesis and stem cell regulation","description":"These proteins cluster around developmental and morphogenetic processes across multiple organs. GO terms include embryonic digestive tract morphogenesis, rostrocaudal neural tube patterning, metanephric nephron tubule formation, lacrimal gland development, and regulation of stem cell proliferation, with supporting signals from steroid hormone response and inflammatory pathways. The common theme is embryonic organ development and tissue patterning, with some terms reflecting broader growth or immune signaling, suggesting a developmental/regulatory cluster rather than a single metabolic function.","confidence":"Medium","size":11,"edges":11,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0048557","count":2},{"id":"GO:0072091","count":2},{"id":"GO:0032808","count":2},{"id":"GO:0021903","count":2}]},{"hash":"1140647285704089343","title":"Larval chitin-based cuticle development","description":"The only top GO term is larval chitin-based cuticle development (GO:0008363), pointing to proteins involved in larval cuticle formation via chitin-related processes. This suggests a cohesive theme around insect cuticle development, despite limited term support, so the label reflects the most specific shared function.","confidence":"High","size":11,"edges":31,"triangles":38,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1}]},{"hash":"447174097757689499","title":"Endosomal-Vacuolar Transport","description":"The top GO terms point to intracellular trafficking involving the Golgi, endosomes, and vacuoles (Golgi to endosome transport; protein targeting to vacuole; late endosome to vacuole transport via MVB sorting). Although other terms are diverse (transcription regulation, reproduction), the shared emphasis on endomembrane/vesicular transport to vacuolar compartments suggests a cohesive function for this cluster. Confidence: Medium","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0043486","count":1},{"id":"GO:0035019","count":1},{"id":"GO:0003014","count":1},{"id":"GO:0009997","count":1}]},{"hash":"1098510073874918156","title":"Developmental morphogenesis and tissue differentiation","description":"The GO terms cluster around tissue formation and patterning (cartilage morphogenesis, pancreatic/endocrine development, placental differentiation, endothelial-to-mesenchymal transition) and angiogenesis, suggesting a developmental morphogenesis theme. Some terms (glucose response, apoptosis, immune defense) are less directly related but can reflect broader stress or maintenance aspects in development. Overall, the group likely reflects genes involved in developmental tissue morphogenesis and differentiation.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0014068","count":2}]},{"hash":"2162549388592734205","title":"Neuronal ER stress and calcium homeostasis","description":"The top terms point to endoplasmic reticulum\u2013related stress responses (ER stress, unfolded protein response, regulation under ER conditions) and calcium ion homeostasis/transport within neurons, along with neuron-specific contexts such as cerebellar granule layer development and response to glutamate. This suggests the cluster represents proteins involved in neuronal stress regulation and calcium signaling, particularly in cerebellar contexts, rather than a single, narrow pathway.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032469","count":1},{"id":"GO:1904721","count":1},{"id":"GO:1990441","count":1},{"id":"GO:0090005","count":1},{"id":"GO:1902042","count":1}]},{"hash":"1951083985429357316","title":"ER protein folding and heat-shock response","description":"The cluster centers on ER-related protein folding and stress responses: terms like protein folding in the endoplasmic reticulum, response to heat and unfolded protein, and redox homeostasis point to chaperone-assisted folding and ER quality control under heat stress. Additional terms about kinase regulation and oligomerization may reflect broader stress-response regulation, but the dominant theme is ER folding and heat-shock quality control.","confidence":"High","size":11,"edges":9,"triangles":2,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006469","count":5},{"id":"GO:0045454","count":4},{"id":"GO:0035719","count":4},{"id":"GO:0051259","count":4},{"id":"GO:0032781","count":4}]},{"hash":"1032201368455381857","title":"Unknown","description":"The top terms span a highly diverse mix of processes (bacterial antigen biosynthesis, development, behavior, receptor trafficking, reproductive binding, cytokine and neuropeptide processing, protein autoprocessing, endocrine secretion, and lipoprotein receptor biosynthesis) with no clear common function or cohesive theme. The absence of network connectivity (edges 0) further supports a lack of a shared role, so a generic Unknown label with no confidence is appropriate.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009246","count":2},{"id":"GO:0060325","count":1},{"id":"GO:0035180","count":1},{"id":"GO:0001920","count":1},{"id":"GO:0007339","count":1}]},{"hash":"830623946640563036","title":"Neuronal signaling and cytoskeletal dynamics","description":"The cluster shows enrichment for nervous system functions, including peripheral nerve myelination, excitatory synaptic activity, and postsynaptic calcium regulation, pointing to neuronal signaling. Microtubule nucleation suggests cytoskeletal organization relevant to synapses. Several outlier terms (complement activation, transcription regulation, stress response, karyogamy, urea homeostasis) may reflect annotation noise or multifunctional proteins, but the dominant theme is neural signaling and cytoskeletal processes.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0022011","count":2},{"id":"GO:0006470","count":1},{"id":"GO:0060079","count":1},{"id":"GO:0045917","count":1},{"id":"GO:2000678","count":1}]},{"hash":"1001454726196934810","title":"Tissue morphogenesis and ECM adhesion","description":"The proteins cluster around development and extracellular matrix interactions: skin and basement membrane formation, cartilage/bone morphogenesis, lymphangiogenesis, and cell adhesion/integrin biosynthesis. While immune and cuticle terms appear, the dominant theme is tissue morphogenesis driven by ECM remodeling and cell\u2013matrix adhesion.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0032836","count":3},{"id":"GO:2000590","count":2},{"id":"GO:0045112","count":2},{"id":"GO:0007155","count":2}]},{"hash":"501020139664366852","title":"Glycosylation and Proteoglycan Metabolism in Reproduction","description":"The cluster\u2019s top GO terms cluster around proteoglycan biosynthesis/metabolism (keratan sulfate proteoglycan biosynthetic and proteoglycan metabolic processes), glycosylation (even noting an obsolete term), and reproductive-related processes such as lactose biosynthesis and zona pellucida penetration. Together these point to extracellular matrix/glycan remodeling and glycan production in reproductive tissues (lactation, mammary involution, fertilization contexts). Some terms like neural development appear discordant and may reflect annotation noise, but the core signal supports glycosylation-proteoglycan pathways tied to reproductive tissue biology.","confidence":"Medium","size":11,"edges":11,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0045136","count":2},{"id":"GO:0021680","count":2},{"id":"GO:0060054","count":2},{"id":"GO:0060058","count":2},{"id":"GO:0006486","count":2}]},{"hash":"1844920698574506610","title":"Chromatin Silencing and DNA Damage Response","description":"The top GO terms point to chromatin modification and heterochromatin formation (H3K9, H3K27, H4K20 trimethylation; rDNA heterochromatin), and to a positive regulation of the intrinsic apoptotic pathway in response to DNA damage, suggesting a nuclear, chromatin-related role tied to genome stability. A few terms (glycosylation, Notch regulation) are less coherent with this theme and may reflect incidental annotations, but the strongest signal is chromatin regulation and DNA damage response.","confidence":"Medium","size":11,"edges":12,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035269","count":1},{"id":"GO:0015693","count":1},{"id":"GO:0018279","count":1},{"id":"GO:0045746","count":1},{"id":"GO:0036124","count":1}]},{"hash":"730588444797604645","title":"Unknown","description":"The terms are highly diverse, including negative regulation of kinase activity, transcription, GTPase activity, and apoptotic processes, plus defense and stress responses and tissue remodeling terms; with no clear shared pathway and no interactions among proteins, there isn\u2019t a cohesive function to name this cluster.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0060348","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0030574","count":2}]},{"hash":"513377909619659383","title":"Cofactor biosynthesis and central metabolism","description":"Top terms point to biosynthesis of cofactors (protoporphyrinogen IX and biotin) and core metabolic pathways (TCA cycle, acetyl-CoA, succinyl-CoA), with a few transcription/redox response terms suggesting regulation of gene expression linked to metabolism. This supports a theme of metabolic biosynthesis integrated with regulatory control.","confidence":"Medium","size":11,"edges":50,"triangles":123,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0006782","count":4},{"id":"GO:0009102","count":4},{"id":"GO:0019878","count":3},{"id":"GO:0019518","count":3}]},{"hash":"1352165218677960953","title":"Unknown","description":"The listed GO terms span many distinct processes (nitrate assimilation, unsaturated fatty acid biosynthesis, sphingolipid metabolism, CNS myelin maintenance, mitochondrial inheritance, various stress responses, sebaceous gland differentiation, chlorophyll metabolism, hypochlorite response, and protein repair) with little overlap. There is no coherent shared function or pathway across these proteins, so a meaningful, specific label cannot be assigned.","confidence":"","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":2},{"id":"GO:0006636","count":1},{"id":"GO:0006675","count":1},{"id":"GO:0032286","count":1},{"id":"GO:0000001","count":1}]},{"hash":"1775163605345594349","title":"Unknown","description":"The top terms span several unrelated developmental themes (chondrocyte, glomerular/kidney development, CNS development, innervation) and signaling pathways, plus an odd bacterial biosynthetic term, with no clear, shared function across the proteins. Edges are zero, so there is no evidence of a cohesive interaction or single pathway linking them. Therefore no confident, representative label can be assigned.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002063","count":2},{"id":"GO:0032836","count":2},{"id":"GO:0035860","count":2},{"id":"GO:0070395","count":2},{"id":"GO:0040037","count":2}]},{"hash":"1141901555589970911","title":"Zinc Ion Transport and Homeostasis","description":"Most terms cluster around zinc uptake and intracellular zinc regulation, including zinc import across the plasma membrane, intracellular zinc homeostasis, and detoxification. The presence of a cadmium transport term suggests metal transport capabilities, but the dominant theme is zinc handling by the cell, including responses to zinc limitation. This supports a label focused on zinc transport and homeostasis for the cluster.","confidence":"High","size":11,"edges":13,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0060173","count":2},{"id":"GO:0044749","count":2},{"id":"GO:0006831","count":2},{"id":"GO:0070574","count":2},{"id":"GO:0006830","count":2}]},{"hash":"2245567351445426146","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0010995","count":1},{"id":"GO:0071108","count":1},{"id":"GO:0006511","count":1},{"id":"GO:0070537","count":1}]},{"hash":"1421743073532361956","title":"Unknown","description":"Top terms are a mix of nuclear proteostasis and DNA processing (nuclear protein quality control by the ubiquitin-proteasome system, DNA recombinase assembly, double-strand break repair via single-strand annealing) alongside more divergent processes (protein transport, cytoskeletal/neurofilament organization, locomotion regulation, sphingolipid homeostasis, tissue cell-number homeostasis). The lack of a clear, cohesive theme across the terms suggests no single representative function for the cluster, so an Unknown label is appropriate.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071630","count":1},{"id":"GO:0045002","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0000730","count":1},{"id":"GO:1990920","count":1}]},{"hash":"244213853750618671","title":"Multisystem Development and Reproductive Processes","description":"Top GO terms are dominated by developmental processes across multiple organs (retina vasculature development, heart development, prostate gland growth, sex differentiation, maternal processes in parturition) with supporting metabolic and detoxification pathways (omega-hydroxylase P450, calcitriol biosynthesis, triglyceride metabolism). This points to a broad theme of developmental regulation across tissues, with metabolic contexts, rather than a single, tight functional module. Confidence: Medium","confidence":"","size":11,"edges":10,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0061298","count":5},{"id":"GO:0009636","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0060736","count":3},{"id":"GO:0033072","count":3}]},{"hash":"824250189289940116","title":"Mitotic cell cycle and COPII transport","description":"The cluster is dominated by terms tied to cell division and mitosis (cell division, mitotic spindle assembly, mitotic cell cycle, multicellular organism growth, cell population proliferation) and vesicle trafficking (COPII-coated vesicle budding, retrograde vesicle-mediated transport). This suggests a cohesive theme around cell proliferation coupled with the secretory pathway essential for growth and division. Immune-related terms are present but less prominent, reinforcing that the core signal is mitosis with associated transport processes.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035264","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0090114","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0006890","count":3}]},{"hash":"632785134178250176","title":"Unknown","description":"The GO terms span diverse areas (immune response, transcription regulation, epigenetics, metabolism, and development) with no clear shared function or connectivity among the proteins, so a cohesive, interpretable label cannot be inferred.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0032496","count":4},{"id":"GO:0031214","count":3},{"id":"GO:0030194","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0006355","count":3}]},{"hash":"616766573243239024","title":"Embryogenesis and organ morphogenesis","description":"The terms point to broad developmental processes across tissues (placenta, pancreas, cartilage, heart, palate) and germ-layer patterning, including EMT events and left-right formation. This suggests a cohesive theme of embryonic tissue morphogenesis and organ development, hence the label.","confidence":"High","size":11,"edges":12,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":9},{"id":"GO:0060806","count":9},{"id":"GO:0003323","count":9},{"id":"GO:0060536","count":9},{"id":"GO:0003198","count":9}]},{"hash":"1182832529454183172","title":"Thymic T-cell development and tolerance","description":"The dominant GO terms point to thymus-related processes (thymus epithelium morphogenesis, thymocyte migration, peripheral T cell tolerance), indicating a cluster centered on thymus-driven T cell maturation and immune tolerance. Obsolete histone modification terms are peripheral, but do not undermine the main thymus/T cell theme.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097536","count":2},{"id":"GO:0098532","count":2},{"id":"GO:0002458","count":2},{"id":"GO:1901536","count":2},{"id":"GO:2000410","count":2}]},{"hash":"1151783461114279232","title":"Unknown","description":"The GO terms cover diverse areas\u2014carbohydrate metabolism, antibiotic response, cell division, ubiquitin-mediated proteolysis, nuclear receptor signaling, menaquinone and polyamine biosynthesis, neuronal migration, platelet aggregation\u2014without a single unifying function. The lack of edges (no direct interactions) and low connectivity further suggest this cluster groups heterogeneous processes rather than a coherent pathway.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0042787","count":2},{"id":"GO:2000324","count":2}]},{"hash":"1755289516875473895","title":"Embryogenesis and organogenesis","description":"These proteins are heavily linked to embryonic development and organ formation. The GO terms cover endocrine development, mesoderm/palate/heart tissue differentiation, and left-right patterning, indicating a cohesive theme of vertebrate embryogenesis and organogenesis.","confidence":"High","size":11,"edges":11,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":8},{"id":"GO:0060806","count":8},{"id":"GO:0003323","count":8},{"id":"GO:0060536","count":8},{"id":"GO:0003198","count":8}]},{"hash":"1538311690420469405","title":"Unknown","description":"The terms span lipoteichoic acid biosynthesis (bacterial cell wall lipid synthesis), regulation of HDL particle clearance (lipid metabolism in humans), basic enzymatic activities (phosphorylation/dephosphorylation, methylation), coenzyme A biosynthesis, and mitosis-related processes. The cluster shows no coherent, single biological theme that ties these terms together across the proteins, implying a mixed or heterogeneous set of functions rather than a distinct, unified pathway. None","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070395","count":2},{"id":"GO:0010983","count":2},{"id":"GO:0016310","count":1},{"id":"GO:0070584","count":1},{"id":"GO:1904251","count":1}]},{"hash":"1596801110493539971","title":"Ubiquitin-dependent proteolysis and deubiquitination","description":"The GO terms show a clear emphasis on ubiquitin turnover, including deubiquitination (K48-, K29-, K63-linked), ubiquitin recycling, and ubiquitin-dependent protein catabolic process, with only a few transcription- or behavior-related terms as minor notes. Therefore the cluster most likely groups proteins implicated in ubiquitin metabolism and proteolysis.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0010995","count":1},{"id":"GO:0071108","count":1},{"id":"GO:0006511","count":1},{"id":"GO:0070537","count":1}]},{"hash":"375596200600038340","title":"Podocyte development and ECM remodeling","description":"This cluster centers on podocyte biology in the kidney, highlighted by metanephric podocyte development, cadherin-mediated adhesion, and extracellular matrix disassembly, all key to the glomerular filtration barrier. Additional terms reflecting excretion and mitochondrial dynamics fit the high-energy needs and turnover of podocytes, while the remaining signaling terms do not contradict this interpretation. Overall, the GO terms cohere around podocyte development and ECM remodeling.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0001302","count":10},{"id":"GO:2000049","count":10},{"id":"GO:0045541","count":10},{"id":"GO:1990046","count":10},{"id":"GO:0072249","count":10}]},{"hash":"753711006284005683","title":"Signaling and remodeling hub proteins","description":"The top GO terms point to signaling-related activities (protein dephosphorylation, excitatory postsynaptic potential, regulation of postsynaptic calcium), membrane remodeling (phosphatidylcholine acyl-chain remodeling), and cytoskeletal dynamics (microtubule nucleation, karyogamy). Although terms like skin development and complement activation appear, the dominant theme is proteins that coordinate signaling with membrane and cytoskeletal remodeling, suggesting a hub of multifunctional signaling and structural regulators.","confidence":"Medium","size":10,"edges":43,"triangles":105,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006470","count":10},{"id":"GO:0060079","count":10},{"id":"GO:0045917","count":10},{"id":"GO:2000678","count":10},{"id":"GO:0043588","count":10}]},{"hash":"1682298691624217434","title":"Ubiquitin-Proteasome Proteolysis in Cell Cycle","description":"The set is enriched for ubiquitin-dependent protein catabolic processes (SCF-dependent, K11-linked ubiquitination, APC/C-related) and for cell cycle transitions (G2/M, metaphase/anaphase, meiotic chromatid movements), indicating a cluster of proteins regulating proteolysis to control mitosis and meiosis. The presence of a viral process term is likely incidental and does not outweigh the proteolysis- and cell-cycle signal.","confidence":"High","size":10,"edges":35,"triangles":61,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":4},{"id":"GO:0042787","count":3},{"id":"GO:0016032","count":3},{"id":"GO:0070979","count":3},{"id":"GO:0070911","count":3}]},{"hash":"186995890307455603","title":"Vesicle trafficking and secretory degranulation","description":"The terms point to SNARE complex assembly, vacuole fusion, and endosome-to-Golgi retrograde transport, plus receptor recycling and intracellular protein transport, indicating vesicle trafficking and membrane fusion processes. The presence of eosinophil and neutrophil degranulation reflects secretory immune effector functions, tying in with regulated secretion. Spanning triglyceride transport and insulin signaling suggests secretory/metabolic vesicle activity as well. Overall, a cohesive theme of vesicle trafficking and secretory degranulation emerges.","confidence":"High","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042144","count":4},{"id":"GO:0035493","count":3},{"id":"GO:0001921","count":3},{"id":"GO:0034197","count":3},{"id":"GO:0032869","count":3}]},{"hash":"179677286398556614","title":"Nuclear transport and spindle assembly","description":"This cluster shows a cohesive set of GO terms tied to nucleocytoplasmic transport (NLS-bearing protein import, Ran signaling, snRNP import, nuclear pore complex assembly) along with centrosome and microtubule-related processes (astral microtubule organization, regulation of centrosome duplication, embryonic cleavage). Together they point to a functional module coordinating nuclear transport with spindle apparatus and cell division machinery.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040016","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0030953","count":1},{"id":"GO:0006607","count":1},{"id":"GO:0031291","count":1}]},{"hash":"1277022100348000212","title":"Multisystem Development and Nervous System Roles","description":"The terms cluster around development across multiple tissues (heart, cartilage, pancreas, placenta, endocrine system) and include nervous system\u2013related processes (regulation of nervous system\u2013driven functions, sensory perception, locomotion, neuron survival) plus a reproductive term (acrosome reaction). This mix suggests broad developmental regulation with nervous system involvement rather than a single, cohesive pathway.","confidence":"Medium","size":10,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002087","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0007605","count":2}]},{"hash":"1682946794944141150","title":"Transmembrane transport of metabolites and ions","description":"The cluster shows multiple GO terms centered on transmembrane transport of organic acids (malate, succinate, citrate) and inorganic ions (sodium, monoatomic anions, phosphate), indicating a membrane transport theme that ties the proteins together. There are some outlier terms related to transcription regulation and ribosome maturation that are less represented, but the dominant signal is transporter activity across membranes.","confidence":"Medium","size":10,"edges":8,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":3},{"id":"GO:0015743","count":2},{"id":"GO:0015744","count":2},{"id":"GO:0098656","count":2},{"id":"GO:0006814","count":2}]},{"hash":"1901915606780312759","title":"DNA Mobility and Proviral Integration","description":"This cluster is dominated by terms related to genetic mobility and viral life-cycle steps: DNA transposition, DNA integration, proviral latency, and virion assembly, plus regulation of DNA-templated transcription. These point to mobilome/retroelement activity and associated transcriptional control. The presence of far-red light signaling and circadian rhythm terms suggests a secondary link to light-regulated transcription, possibly reflecting co-regulated host pathways interacting with mobile genetic elements. Overall, the core theme appears to be DNA mobility with viral integration and expression control.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0006355","count":3}]},{"hash":"2276292402568548510","title":"Ribosome Biogenesis and rRNA Processing","description":"The top GO terms are strongly centered on ribosome production, including large subunit biogenesis, LSU rRNA maturation, and export from the nucleus, which together point to proteins involved in ribosome assembly and rRNA processing. Additional RNA modification steps (methylation and capping) and a minor chromatin organization signal suggest coordinated, nucleus-associated RNA processing related to ribosome biogenesis. Thus, the cluster most likely comprises factors in ribosome assembly and rRNA maturation.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":3},{"id":"GO:0000463","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0031497","count":2}]},{"hash":"1798208916361122569","title":"Ribosome biogenesis and translation machinery","description":"Dominant GO terms point to protein synthesis and ribosome-related processes: translation, cytoplasmic translation, ribosome biogenesis, tRNA modification, and SRP-dependent cotranslational targeting to membranes, indicating a cluster focused on ribosome function and protein targeting. Some terms like response to antibiotic and outliers such as brain development or flagellum organization likely reflect noise or cross-species annotations, but do not override the central translation and ribosome assembly theme.","confidence":"High","size":10,"edges":36,"triangles":77,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0046677","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0002181","count":2}]},{"hash":"1485802468911480519","title":"Unknown","description":"The GO terms span neural signaling, cytoskeleton, membrane remodeling, immune/skin development, stress responses, and even nuclear fusion, with no clear unifying process across all proteins. Therefore there is no coherent functional theme to assign a concise label.","confidence":"","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006470","count":1},{"id":"GO:0060079","count":1},{"id":"GO:0045917","count":1},{"id":"GO:2000678","count":1},{"id":"GO:0033555","count":1}]},{"hash":"2097415948643988749","title":"Unknown","description":"The terms are highly diverse, including mRNA capping, mitotic chromatid biorientation, JNK and PI3K/AKT signaling regulation, macroautophagy, starch metabolism, inflammatory response modulation, Notch signaling, host-symbiont interactions, and habituation. There is no clear, cohesive biological theme tying these proteins together, so a specific functional label is not supported.","confidence":"","size":10,"edges":11,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":2},{"id":"GO:0098783","count":2},{"id":"GO:0043508","count":2},{"id":"GO:0016239","count":2},{"id":"GO:0005983","count":2}]},{"hash":"851375223599478695","title":"Mitochondrial apoptosis and cytokine production","description":"The top GO terms point to regulation of mitochondrial-mediated apoptosis (negative regulation of mitochondrial depolarization, cytochrome c release, and extrinsic pathway regulation) and production of inflammatory cytokines IL-1\u03b2 and IL-18. Some terms involve membrane trafficking and neural-related processes, suggesting broader cellular stress responses, but the strongest signal is apoptosis control linked to inflammatory signaling. ","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0016320","count":2},{"id":"GO:0045037","count":2},{"id":"GO:0051902","count":1},{"id":"GO:0043154","count":1},{"id":"GO:2001240","count":1}]},{"hash":"1813908227950193887","title":"Membrane nutrient transport","description":"Most of the top GO terms point to transport across membranes of nutrients and ions (myo-inositol, pantothenate, biotin, D-glucose, sodium ions). This suggests a cluster of proteins primarily involved in transmembrane nutrient movement, with a few unrelated or low-frequency terms (e.g., acetylcholine biosynthesis) contributing less to the overall theme.  ","confidence":"High","size":10,"edges":15,"triangles":6,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0015798","count":7},{"id":"GO:0015887","count":7},{"id":"GO:0008292","count":7},{"id":"GO:0071436","count":7},{"id":"GO:0015878","count":7}]},{"hash":"1413381519554553080","title":"P450-mediated lipid and hormone metabolism","description":"The cluster is dominated by GO terms tied to cytochrome P450\u2013driven lipid and hormone pathways\u2014omega-hydroxylase and epoxygenase activities, prostaglandin and calcitriol biosynthesis, and triglyceride metabolism\u2014suggesting a coherent module of P450-catalyzed lipid/hormone processing, with some developmental/hormonal differentiation terms as ancillary connections.","confidence":"High","size":10,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060736","count":9},{"id":"GO:0033072","count":9},{"id":"GO:0036378","count":9},{"id":"GO:0097267","count":9},{"id":"GO:0006641","count":9}]},{"hash":"1775101511260364698","title":"Retinoid and steroid hormone metabolism in reproduction","description":"This cluster prominently features retinoid metabolism (retinal and retinol) alongside steroid hormone biosynthesis (C21-steroid), with reproductive context terms like male gonad development and maternal pregnancy. A cohesive theme is metabolism of lipophilic signaling molecules (vitamin A derivatives and steroid hormones) that influence reproductive biology and tissue homeostasis, despite some auxiliary metabolism terms present.","confidence":"Medium","size":10,"edges":32,"triangles":58,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":7},{"id":"GO:0042572","count":7},{"id":"GO:0008584","count":5},{"id":"GO:0044597","count":5},{"id":"GO:0097238","count":5}]},{"hash":"2146733860259359303","title":"Retroviral DNA integration and latency","description":"The top GO terms cluster around the retroviral life cycle: DNA replication, DNA integration, establishment of integrated proviral latency, RNA-templated DNA synthesis, and DNA recombination, all pointing to viral genome integration and latency rather than generic host DNA metabolism. Additional terms about viral entry into the host nucleus and symbiont-host interactions support a viral-host association. Therefore, this label captures the dominant theme of proviral integration and latency in this set.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0046718","count":2}]},{"hash":"808769572232927676","title":"Male reproductive development and spermatogenesis","description":"The top GO terms cluster around male gonad development, Sertoli cell development, and sperm-egg interaction (binding of sperm to zona pellucida), with supporting terms like response to estradiol and regulation of cell proliferation and apoptotic processes\u2014collectively pointing to Sertoli cell function and spermatogenesis within the male reproductive system. Some developmental terms for ectoderm-derived tissues (eye, epidermis) may reflect pleiotropy or shared developmental regulators, but the dominant signal is reproductive development. ","confidence":"High","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":2},{"id":"GO:0001654","count":2},{"id":"GO:0008544","count":2},{"id":"GO:0002839","count":2},{"id":"GO:0060311","count":2}]},{"hash":"2174440915029188139","title":"Golgi trafficking and ribosome biogenesis","description":"This cluster centers on ribosome assembly/export (small and large subunits) and Golgi-related processes (Golgi-to-lysosome transport, Golgi organization, and protein retention), suggesting a shared role in coordinating protein synthesis with secretory pathway processing. Some stress-response related terms appear but are less dominant.","confidence":"Medium","size":10,"edges":12,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0090160","count":2},{"id":"GO:0042274","count":2},{"id":"GO:1901001","count":2},{"id":"GO:1903833","count":2},{"id":"GO:0000055","count":2}]},{"hash":"644066333691161335","title":"Signaling Pathway Modulation and Pain Response","description":"The GO terms cluster around regulation of signaling activity (GTPase/Rho, kinases) and membrane potential, with links to pain and morphine response, indicating a group tied to modulation of neural and signaling pathways.","confidence":"Medium","size":10,"edges":11,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0006469","count":3},{"id":"GO:0090198","count":2},{"id":"GO:0051930","count":2},{"id":"GO:0043278","count":2}]},{"hash":"1936313730933002000","title":"Plant secondary cell wall polysaccharide biosynthesis","description":"The top GO terms point to plant-specific cell wall construction, especially secondary cell wall biogenesis and glucuronoxylan biosynthesis, which are hallmarks of plant cell wall polysaccharide production. The presence of related glycosylation terms suggests wall-associated glycoproteins and processing involved in assembling cell wall components, including pollen exine formation. Together, these indicate a cohesive function in plant cell wall biosynthesis and related glycosylation processes.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":2},{"id":"GO:0009834","count":2},{"id":"GO:0010417","count":2},{"id":"GO:0050650","count":1},{"id":"GO:0030204","count":1}]},{"hash":"1568633911296324233","title":"Neural crest and inner ear morphogenesis","description":"This cluster is dominated by terms linked to neural crest cell development, inner ear morphogenesis, neuromuscular processes controlling balance, and retinoic acid signaling, all pointing to embryonic neural development and sensory/vestibular tissue formation. While a couple of terms (e.g., some metabolic or obsolete processes) may be less relevant, the core theme ties neural crest\u2013derived tissues to ear/balance morphogenesis. ","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0048384","count":10},{"id":"GO:0042472","count":10},{"id":"GO:0009954","count":10},{"id":"GO:0019285","count":10},{"id":"GO:0009450","count":10}]},{"hash":"538825920924816857","title":"Unknown","description":"The terms span RNA processing (mRNA capping and RNA guanine-N7 methylation), various metabolic pathways (cobalamin and ubiquinone biosynthesis), and broad stress/response processes (epinephrine biosynthesis, xenobiotic responses, regeneration, and senescence). There isn\u2019t a single coherent function tying all proteins together, so a concise, representative label isn\u2019t apparent. ","confidence":"","size":10,"edges":13,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":5},{"id":"GO:0042418","count":5},{"id":"GO:0010243","count":5},{"id":"GO:0031100","count":5},{"id":"GO:0009236","count":5}]},{"hash":"2097566893010454926","title":"Mitotic/meiotic chromosome condensation and cohesion","description":"The GO terms cluster around chromosome condensation during mitosis and meiosis, sister chromatid cohesion and segregation, and DNA replication, indicating a shared role in organizing and maintaining chromosome architecture through cell division.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":4},{"id":"GO:0010032","count":2},{"id":"GO:0098813","count":1},{"id":"GO:0007076","count":1},{"id":"GO:0060821","count":1}]},{"hash":"2023795934640579886","title":"Unknown","description":"The top GO terms are extremely diverse, ranging from telomere regulation and capping to membrane localization, immune signaling, sensory perception, and ubiquitination, with no single shared process or cellular context evident across the cluster. This makes a coherent, specific label unlikely.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904743","count":3},{"id":"GO:0072660","count":3},{"id":"GO:0009409","count":3},{"id":"GO:0035544","count":3},{"id":"GO:0010745","count":3}]},{"hash":"1702620029199203600","title":"Development, Cell Cycle, and Telomere Regulation","description":"The top GO terms cluster around developmental programs (fat cell differentiation, multicellular organism development) and processes tied to cell division and genome maintenance (mitotic cell cycle, regulation of CDK activity, telomere maintenance/capping). This suggests a cohesive theme of development linked to cell-cycle control and telomere regulation, despite some peripheral terms like mRNA processing. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045444","count":8},{"id":"GO:1904355","count":8},{"id":"GO:0000278","count":8},{"id":"GO:2001275","count":8},{"id":"GO:0006397","count":8}]},{"hash":"1695996205027872878","title":"Chromatin organization and histone modification","description":"The top GO terms cluster around chromatin biology\u2014nucleosome assembly, heterochromatin organization, and histone modifications (H3-K27 and H3-K4 methylation) with related localization to chromatin and nuclear processes. Although several terms are labeled obsolete, the core theme is chromatin architecture and its regulation.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":1},{"id":"GO:0016584","count":1},{"id":"GO:0098532","count":1},{"id":"GO:0097298","count":1},{"id":"GO:0071169","count":1}]},{"hash":"1894257758909718627","title":"Retroviral infection and proviral latency","description":"The terms point to a retroviral life cycle: entry into host cells, penetration into the nucleus, reverse transcription (RNA-templated DNA biosynthesis), integration of viral DNA into the host genome, and proviral latency. Additional terms about DNA replication/recombination and suppression of host RNAi, as well as modulation of host apoptosis, fit the virus\u2019s replication strategy and host interaction. This cohesive pattern strongly supports labeling the cluster as retroviral infection and proviral latency.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046718","count":9},{"id":"GO:0075732","count":9},{"id":"GO:0006260","count":9},{"id":"GO:0075713","count":9},{"id":"GO:0006310","count":9}]},{"hash":"2246791349363944873","title":"Unknown","description":"The GO terms are highly diverse, spanning GTPase regulation, aging, inflammatory cytokine production, RNA processing, metabolic signaling, embryonic and skin development, pattern formation, peroxisome targeting, and rRNA maturation. There is no clear, cohesive biological theme tying these functions together, and the network has no edges, suggesting possible annotation noise or a mixed set of proteins. Therefore, a specific, representative label is not justifiable.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0002534","count":3},{"id":"GO:0000348","count":3},{"id":"GO:0010255","count":3}]},{"hash":"849181025885735675","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0019068","count":2},{"id":"GO:0030260","count":2},{"id":"GO:0015074","count":2}]},{"hash":"1842604277452772769","title":"Neural development and cell adhesion","description":"The cluster centers on neural development signals (lateral motor column neuron migration; midbrain dopaminergic neuron differentiation) and adjacent cell-adhesion processes (receptor clustering; hemidesmosome assembly; substrate adhesion-dependent cell spreading), suggesting coordinated neuronal differentiation with cell\u2013matrix interactions. A few terms (platelet aggregation; regulation of Hippo signaling) appear as broader signaling contexts but are less central to the core theme.","confidence":"Medium","size":9,"edges":24,"triangles":25,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0097477","count":5},{"id":"GO:0070527","count":5},{"id":"GO:1904948","count":4},{"id":"GO:0043113","count":4},{"id":"GO:0031581","count":4}]},{"hash":"1842012223157097840","title":"mRNA Splicing and Polyadenylation Regulators","description":"The top terms emphasize spliceosome-mediated mRNA splicing, regulation of splicing, polyadenylation and tail shortening, plus mRNA stabilization. This points to a cluster of proteins involved in post-transcriptional RNA processing rather than translation, justifying a label focused on splicing/polyadenylation regulation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":2},{"id":"GO:1900363","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0060211","count":2},{"id":"GO:0075522","count":2}]},{"hash":"804787879799096991","title":"Axon guidance and neural development","description":"The cluster\u2019s top GO terms are dominated by neural-related processes: axon guidance (GO:0007411), Roundabout signaling (GO:0035385), and nervous system development (GO:0007399), plus positive regulation of ERK cascade (GO:0070374). Together these point to roles in neural connectivity and pathway signaling during neural development. While a few terms (spermatid development, ossification) are less aligned, the core theme appears to be neuronal patterning and axon pathfinding.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043552","count":5},{"id":"GO:0007286","count":5},{"id":"GO:0007411","count":5},{"id":"GO:0035385","count":5},{"id":"GO:0070374","count":5}]},{"hash":"1585490983421076596","title":"RNA processing and ribosome biogenesis","description":"This cluster strongly features RNA metabolism steps (mRNA splicing, rRNA processing, and ribosomal subunit export), suggesting a role in RNA processing and ribosome assembly. A defense-related term is present but seems incidental and does not define the group's core function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0032298","count":1},{"id":"GO:1903026","count":1},{"id":"GO:0000398","count":1}]},{"hash":"444376650015497964","title":"Cardiac muscle development and contraction regulation","description":"This cluster centers on heart-related development and function: heart development, regulation of cardiac muscle contraction, calcium signaling and NFAT pathway activity, and related actin/cytoskeleton dynamics, suggesting proteins involved in cardiac muscle formation and its electrical/contractile regulation. A few terms reference metanephric development, but the dominant theme is cardiac.","confidence":"High","size":9,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051764","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0070886","count":2},{"id":"GO:0042694","count":2}]},{"hash":"1881659987383771693","title":"Translation Initiation and Inflammatory Signaling","description":"This cluster is driven by translation-related terms (translation, translational initiation, initiation complex formation) alongside terms for inflammatory mediator production and chemokine regulation, suggesting proteins involved in protein synthesis that also participate in immune signaling. A few neuronal morphology terms (dendrite extension, dendritic spine development) appear, which may reflect broader roles in neural inflammatory responses. Overall, the shared theme centers on translation machinery coupled with inflammatory signaling.","confidence":"Medium","size":9,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006032","count":2},{"id":"GO:0090197","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0002532","count":2}]},{"hash":"751181303262063591","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":1},{"id":"GO:0039651","count":1},{"id":"GO:0019068","count":1},{"id":"GO:0030260","count":1},{"id":"GO:0000398","count":1}]},{"hash":"1993794016816957960","title":"Insect antennal and eye development","description":"Top terms suggest a focus on insect sensory organ development (antennal and compound eye photoreceptor development) with associated transcriptional regulation, indicating a regulatory developmental program for sensory organs. Other terms (metabolic and immune-related) are present but less coherent with the main theme, so the link is moderate rather than strong. Overall, the cluster is best described as relating to insect sensory organ development with transcriptional control.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0007469","count":1},{"id":"GO:0045316","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0045429","count":1}]},{"hash":"226316564723468601","title":"Oxidative Stress Response and NF-kB Regulation","description":"The cluster is dominated by redox-related processes (redox homeostasis, cellular/oxidative stress response, oxidant detoxification) and NF-kB signaling components (I-kappaB phosphorylation, non-canonical NF-kB regulation), suggesting a core theme of oxidative stress management and immune signaling. ER protein folding implies ER stress linked to redox balance; a few terms like magnesium transport and male gonad development are less clearly connected but do not override the main theme.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0034975","count":3},{"id":"GO:0015693","count":3},{"id":"GO:0042345","count":3},{"id":"GO:0007252","count":3}]},{"hash":"1226998782239199522","title":"Neural development and immune signaling","description":"This cluster\u2019s top terms center on neural processes (nerve impulse transmission, trigeminal nerve organization, sympathetic neuron guidance) alongside immune-related pathways (cytokine regulation, Fc receptor signaling, MHC I antigen presentation) and broader developmental processes (angiogenesis, ossification). The combination suggests a theme of developmental signaling that links neural and immune/vascular systems, rather than a single, narrow function.","confidence":"Medium","size":9,"edges":9,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0032516","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0043931","count":5},{"id":"GO:0019226","count":4},{"id":"GO:0002720","count":4}]},{"hash":"2185761594221039562","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0019068","count":2},{"id":"GO:0030260","count":2}]},{"hash":"2296347753437491629","title":"Neuronal development and metabolism","description":"The cluster includes neuronal development terms (pyramidal neuron development, olfactory bulb mitral cell layer development, cerebellar cortex development) together with core metabolic processes (glycolysis, TCA cycle, glucose and glyoxylate metabolism), suggesting a grouping of brain development with associated energy metabolism pathways.","confidence":"Medium","size":9,"edges":28,"triangles":42,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0006096","count":3},{"id":"GO:0022028","count":2},{"id":"GO:0021860","count":2}]},{"hash":"892808121179805365","title":"Unknown","description":"The set includes apoptosis, neural development regulation, stress responses (hyperoxia, cold), embryonic development, and a variety of metabolic processes (beta-alanine biosynthesis, glutathione metabolism, TCA cycle, porphyrin biosynthesis). This broad mix does not point to a single coherent function or pathway, making a specific, representative label unreliable.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0010976","count":2},{"id":"GO:0071455","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0009409","count":2}]},{"hash":"1189673230665934914","title":"Diverse Metabolic Biosynthesis and Degradation","description":"The top GO terms span multiple biosynthetic pathways (biotin, menaquinone, strigolactone, poly-hydroxybutyrate) as well as catabolic processes (1,2-dichloroethane, triglyceride, beta-ketoadipate) and detoxification. This pattern suggests a cluster of proteins involved in varied metabolic processes\u2014both synthesis and breakdown\u2014rather than a single specific pathway, hence a broad metabolic cluster.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0009102","count":3},{"id":"GO:0042619","count":2},{"id":"GO:0009234","count":2},{"id":"GO:0019260","count":2}]},{"hash":"731357976001549861","title":"Neural differentiation and transcriptional regulation","description":"This cluster centers on neural development and neuron fate specification, with GO terms for motor neuron, GABAergic interneuron differentiation, spinal cord and subpallium fate, plus transcription-related terms (RNA polymerase II transcription and mRNA capping). Although a few terms reference other tissues, the dominant signal is neural development coupled with transcriptional control.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":5},{"id":"GO:0031018","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0021520","count":4},{"id":"GO:0021892","count":4}]},{"hash":"1992569282362640329","title":"Inflammation-Linked Tissue Development","description":"This cluster shows a mix of inflammatory signaling terms (IL-1/IL-6 responses, NF-kappaB activation, IL-8 production) together with tissue development processes (biomineral tissue, cartilage, chitin-based cuticle). The common thread appears to be inflammation-associated remodeling and morphogenesis rather than a single, coherent pathway, suggesting a cross-talk between immune signaling and tissue development across contexts.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031214","count":2},{"id":"GO:0030194","count":2},{"id":"GO:0006032","count":2},{"id":"GO:0072606","count":2},{"id":"GO:0007250","count":2}]},{"hash":"1043037191073542791","title":"Neural and Photoreceptor Development and Signaling","description":"This cluster prominently features neural development and sensory signaling terms (neural tube patterning, photoreceptor cell development, blue light signaling, action potential) along with related signaling and trafficking processes (glucose signaling, phosphatidylinositol biosynthesis, ER-to-Golgi transport) and pigment-related differentiation (melanocyte differentiation). While some terms are more general cellular processes (copper homeostasis, myeloid apoptosis), the core theme centers on neural/sensory development and signaling, with photoreceptor context.","confidence":"Medium","size":9,"edges":26,"triangles":39,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006878","count":6},{"id":"GO:0010255","count":6},{"id":"GO:0009785","count":6},{"id":"GO:0021532","count":6},{"id":"GO:0033028","count":6}]},{"hash":"662157513025355491","title":"Notch signaling and metabolism cluster","description":"Although not all terms are tightly connected, the strongest shared function is Notch signaling (Notch signaling pathway) alongside multiple metabolic processes (L-alanine and L-kynurenine/tryptophan catabolism, sphingomyelin and heme biosynthesis, fatty acid transport) and insulin response. This suggests a cluster of proteins tied to both signaling and core metabolism, potentially reflecting cross-talk between pathways.","confidence":"Medium","size":9,"edges":23,"triangles":26,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042853","count":7},{"id":"GO:0007219","count":6},{"id":"GO:0097053","count":6},{"id":"GO:0019878","count":6},{"id":"GO:0006686","count":5}]},{"hash":"818168424602156951","title":"Chromatin Modification and Chromosome Maintenance","description":"The terms cluster around chromatin organization and modification (chiasma assembly, heterochromatin formation, histone phosphorylation/ubiquitination, SUMO-related activity) and cell-cycle processes, suggesting a chromatin-centric role in chromosome maintenance and division; a few outliers exist but do not define the core theme.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0051026","count":9},{"id":"GO:0033128","count":9},{"id":"GO:0006915","count":9},{"id":"GO:0060340","count":9},{"id":"GO:0016562","count":9}]},{"hash":"1233805344834585455","title":"RNA maturation and post-transcriptional regulation","description":"The cluster centers on RNA processing/modification, with strong signals for 7-methylguanosine capping, guanine-N7 methylation, and regulation of mRNA stability, suggesting involvement in RNA maturation and post-transcriptional control. Other terms like response to xenobiotic stimulus and redox homeostasis hint at broader cellular stress responses, but the RNA-processing theme is most prominent.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":5},{"id":"GO:0006370","count":4},{"id":"GO:0036265","count":4},{"id":"GO:0010243","count":3},{"id":"GO:0031100","count":3}]},{"hash":"227007870695239588","title":"Glycosaminoglycan biosynthesis and sulfation","description":"The top GO terms cluster around the biosynthesis and modification of glycosaminoglycans (heparan and chondroitin/keratan sulfate) and related sulfation pathways (sulfate assimilation, N-acetylglucosamine metabolism), pointing to proteoglycan assembly and sulfation as the core function of this group. Other terms like xenobiotic and thyroid hormone metabolism appear broader, but the strongest shared signal is glycosaminoglycan formation and modification.","confidence":"High","size":9,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000103","count":4},{"id":"GO:0030210","count":4},{"id":"GO:0030206","count":4},{"id":"GO:0009812","count":4},{"id":"GO:0042403","count":4}]},{"hash":"84676826560482856","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0000122","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0039651","count":1},{"id":"GO:0019068","count":1}]},{"hash":"2262265469836442631","title":"Unknown","description":"The terms are highly heterogeneous, ranging from mitochondrial inheritance and spindle orientation to membrane repair, pigment/granule transport, secretory granule localization, and various development-related processes. There is no single cohesive function or pathway that ties these proteins together, making a specific, representative label unreliable.","confidence":"","size":9,"edges":13,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0000001","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0001778","count":1},{"id":"GO:0051904","count":1},{"id":"GO:0021678","count":1}]},{"hash":"1630397864481359422","title":"Mitochondrial energy metabolism and insulin signaling","description":"The terms cluster around energy production and mitochondrial function: adaptive thermogenesis, fatty acid response, and regulation of mitochondrial membrane potential all point to energy expenditure and mitochondrial activity. Transport of coenzymes (thiamine pyrophosphate, coenzyme A) across membranes and magnesium export from mitochondrion further reflect core mitochondrial metabolism. Insulin-related responses (cellular response to insulin stimulus and regulation of insulin secretion in response to glucose) tie metabolic signaling to energy production, with liver-related processes (liver regeneration) possibly reflecting metabolic tissue remodeling.","confidence":"Medium","size":9,"edges":12,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1990845","count":2},{"id":"GO:0030974","count":2},{"id":"GO:0007565","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0061179","count":2}]},{"hash":"1567908403628967982","title":"ECM remodeling and angiogenesis","description":"Based on the top GO terms, the proteins are associated with extracellular matrix disassembly, plasminogen activation/fibrinolysis, smooth muscle cell migration, and positive regulation of angiogenesis, suggesting a module focused on ECM remodeling and vascular/regional tissue remodeling. Some terms also reflect development or signaling regulation, but the core theme centers on matrix remodeling and angiogenic processes.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902947","count":2},{"id":"GO:2000097","count":2},{"id":"GO:0071333","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0051919","count":2}]},{"hash":"817827449075380375","title":"Protein Folding and DNA Replication Core","description":"This cluster is driven by GO terms for chaperone-dependent protein refolding, iron-sulfur cluster assembly, and DNA replication, pointing to a core set of housekeeping functions that maintain proteome quality and genome duplication. Some terms (stress/apoptosis regulation, fungal cell wall biosynthesis) may reflect annotation noise or broader stress-related contexts, but the strongest cohesive theme is folding/replication machinery.","confidence":"Medium","size":8,"edges":18,"triangles":21,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0016226","count":5},{"id":"GO:1902037","count":5},{"id":"GO:1903382","count":5}]},{"hash":"855389467830334483","title":"Innate immune signaling with neuroimmune links","description":"The cluster is strongly enriched for innate immune-related GO terms such as innate immune response, cellular response to lipopolysaccharide, response to exogenous dsRNA, and defense response to Gram-positive bacteria, indicating a core grouping around immune sensing and signaling. In addition, terms like axonogenesis, positive regulation of synapse assembly, and behavioral response to formalin-induced pain suggest potential cross-talk between immune pathways and nervous system processes, pointing to a neuroimmune connection as a secondary theme. Together, these terms support labeling the cluster as innate immune signaling with neuroimmune links.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0043330","count":2},{"id":"GO:0046827","count":2}]},{"hash":"1077382538391387880","title":"Mitotic spindle assembly and microtubule dynamics","description":"The dominant terms describe mitosis-related processes anchored in the microtubule cytoskeleton: mitotic metaphase chromosome alignment, spindle assembly, spindle midzone assembly, and nuclear migration along microtubules, as well as polarity of the microtubule network. Although some terms touch on broader signaling (ERK cascade, angiogenesis) or plant-specific chloroplast movement, the core pattern across the cluster points to microtubule-driven cell division and spindle organization. This makes \"Mitotic spindle assembly and microtubule dynamics\" a concise, representative label.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035617","count":2},{"id":"GO:0007080","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0009904","count":1}]},{"hash":"655789942109892016","title":"Mitotic Spindle and Microtubule Dynamics","description":"This cluster is dominated by GO terms tied to microtubule-based processes and mitosis, including mitotic spindle assembly, spindle midzone formation, centrosome separation, microtubule cytoskeleton polarity, and nuclear migration along microtubules, as well as chloroplast movement, which in plants involves microtubule-guided organelle positioning. Although a few terms relate to signaling and epidermal stem cell homeostasis, the core theme centers on microtubule organization and mitotic/division-related dynamics, suggesting a cohesive cytoskeleton/mitosis function cluster.","confidence":"High","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0009904","count":8},{"id":"GO:0090307","count":8},{"id":"GO:0030951","count":8},{"id":"GO:0033624","count":8},{"id":"GO:0030473","count":8}]},{"hash":"1418296366552179529","title":"Gametogenesis and chromatin regulation","description":"This cluster has several GO terms tied to reproductive development (male gonad development, oogenesis) and chromatin dynamics (establishment of protein localization to chromatin, negative regulation of chromosome condensation, rDNA heterochromatin formation, histone phosphorylation regulation). Together these point to a theme of germ cell development accompanied by chromatin remodeling and chromatin-state control, with a few outliers (e.g., pericardium morphogenesis, mucosal innate immunity) that are less central to the main pattern. Confidence: Medium","confidence":"","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":3},{"id":"GO:0003344","count":3},{"id":"GO:0045618","count":3},{"id":"GO:0033128","count":3},{"id":"GO:0002227","count":3}]},{"hash":"1402565756237786038","title":"Heat-stress proteostasis and ER folding","description":"Enriched terms cluster around heat response, unfolded protein response, ER protein folding, and redox homeostasis, indicating a proteostasis core that handles misfolded proteins and ER targeting under thermal stress.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0035719","count":3},{"id":"GO:0051259","count":3},{"id":"GO:0032781","count":3},{"id":"GO:1900035","count":3}]},{"hash":"1000971568846958700","title":"Wnt signaling in neural development and dendrite morphogenesis","description":"Dominant annotation is positive regulation of canonical Wnt signaling, with additional terms related to neuronal apoptosis regulation, dendrite morphogenesis, and cell cycle. This combination suggests a cluster centered on Wnt pathway functions in neural development, neuronal survival, and growth/dendrite formation.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":7},{"id":"GO:0043525","count":6},{"id":"GO:0043524","count":6},{"id":"GO:0010796","count":6},{"id":"GO:0031384","count":6}]},{"hash":"1032733836771698786","title":"Spliceosome-driven mRNA processing and export","description":"The cluster shows strong representation of GO terms related to mRNA splicing via the spliceosome, regulation and alternative splicing, and mRNA export from the nucleus, with additional signals of translational initiation regulation. This points to a cohesive module centered on post-transcriptional processing of mRNA and its nuclear export, with coordination to translation control.","confidence":"High","size":8,"edges":21,"triangles":24,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":6},{"id":"GO:1900363","count":6},{"id":"GO:0048026","count":6},{"id":"GO:0006406","count":6},{"id":"GO:0006446","count":6}]},{"hash":"2187734959062012796","title":"Complement and T Cell Regulation","description":"The top GO terms show a clear emphasis on the complement system (activation, regulation, receptor signaling) and T cell control (homeostatic proliferation, activation-induced cell death), indicating the cluster centers on immune modulation via complement and T cell pathways. A few neural-related terms (synapse maturation, Purkinje cell development) and thyroid hormone generation appear as less representative annotations, suggesting possible pleiotropy rather than core function. Overall, the dominant theme is immune regulation through complement and T cell signaling.","confidence":"Medium","size":8,"edges":9,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0034392","count":1},{"id":"GO:0045959","count":1},{"id":"GO:0046013","count":1},{"id":"GO:0006958","count":1},{"id":"GO:0039573","count":1}]},{"hash":"2272324949580122473","title":"Ribosome Biogenesis and Translation","description":"The proteins show strong enrichment for ribosome-related processes: cytoplasmic translation, ribosome biogenesis, and large-subunit assembly, plus SRP-dependent cotranslational targeting to membranes, which are components of ribosome assembly and protein synthesis pathways. Other scattered terms (endosome trafficking, abscission, viral release) appear incidental, not forming a coherent alternative theme.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071353","count":1},{"id":"GO:0000027","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0006614","count":1}]},{"hash":"395436965197698859","title":"Tyrosine kinase signaling and apoptosis","description":"The top GO term is peptidyl-tyrosine autophosphorylation, which points to tyrosine kinase\u2013driven signaling. Other terms indicate diverse signaling pathways (Ras, LPS-mediated signaling), cytoskeletal remodeling (lamellipodium morphogenesis), vascular/muscle signaling, NK cell activity, and apoptotic processes, suggesting a network of kinase-mediated signaling linked to cell fate decisions. Thus, a concise label capturing tyrosine kinase\u2013dependent signaling with apoptosis is appropriate, acknowledging the breadth of related pathways.","confidence":"Medium","size":8,"edges":6,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0038083","count":3},{"id":"GO:2000394","count":3},{"id":"GO:1900275","count":3},{"id":"GO:1900740","count":3},{"id":"GO:1990441","count":3}]},{"hash":"1391215350740166115","title":"Transcription and Oxidative Stress Regulators","description":"This cluster centers on genes involved in transcription regulation (negative regulation of RNA polymerase II transcription; DNA-templated transcription) and cellular responses to oxidative stress (cellular redox homeostasis; cellular response to oxidative stress; cellular oxidant detoxification), with ER protein folding also linked to stress responses. While a couple terms relate to immune/viral contexts, the dominant pattern ties transcription control to redox/homeostatic stress management, suggesting a cohesive theme of transcriptional and oxidative stress regulation.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0018401","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0006351","count":1}]},{"hash":"319717315317175388","title":"Embryonic Development and Organogenesis","description":"GO terms cluster around developmental processes across diverse tissues (retina, endocrine/pancreatic development, cartilage morphogenesis, left-right patterning, EMT in heart cushion formation, trophoblast differentiation), suggesting a cohesive theme of embryogenesis and organ formation. While one term appears unrelated (photosynthetic pathway), the dominant signal is development and differentiation across tissues.","confidence":"Medium","size":8,"edges":8,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":4},{"id":"GO:0035270","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060536","count":3}]},{"hash":"1453336289086772082","title":"Embryonic development and mesodermal morphogenesis","description":"The Top Terms point strongly to embryonic development and tissue morphogenesis, including mesoderm development, cartilage morphogenesis, endocardial cushion formation, and endocrine system development, with pancreatic and other organ-specific developmental terms reinforcing a developmental program. A few terms concern general cellular processes (mRNA splicing and ribosomal export) that are common across proteins, but the dominant developmental signal supports this label.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":1},{"id":"GO:0060806","count":1},{"id":"GO:0003323","count":1},{"id":"GO:0060536","count":1},{"id":"GO:0032298","count":1}]},{"hash":"1283836772158251973","title":"Metabolic Stress Response and Immune Signaling","description":"The top GO terms point to metabolic processes (GTP biosynthesis, gluconeogenesis regulation, carbohydrate metabolism, glucose starvation response) alongside immune-related activities (lymphocyte proliferation, interleukin-4 response) and a cell-cycle related regulation term. This mix suggests a cluster where metabolic stress responses are linked with immune signaling and proliferative processes, rather than a single tight functional theme. Confidence: Medium","confidence":"","size":8,"edges":15,"triangles":13,"max_degree":7,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006183","count":4},{"id":"GO:0046651","count":4},{"id":"GO:0006565","count":4},{"id":"GO:0045722","count":4},{"id":"GO:0006535","count":4}]},{"hash":"2113718491121214074","title":"Membrane Transporters and Xenobiotic Export","description":"The GO terms are largely about transport across membranes\u2014phospholipid translocation, cadmium ion and nutrient (carbohydrate, branched-chain amino acid, cysteine) transport, and xenobiotic export\u2014pointing to a cluster of membrane transporter proteins. An outlier term about MHC class I antigen processing is likely incidental, but the dominant signal is transport-related. The fenofibrate response also supports a drug-related transport role.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0045332","count":4},{"id":"GO:0070574","count":3},{"id":"GO:0046618","count":3},{"id":"GO:0008643","count":3},{"id":"GO:0015803","count":3}]},{"hash":"383299626544694305","title":"Unknown","description":"The top terms span mitochondrial membrane regulation, inflammatory cytokine production, RNA processing, glucose signaling, various developmental processes, peroxisome targeting, and growth hormone response, with no single dominant theme. The annotations are heterogeneous and the cluster has no edges or clear connectivity, so there isn\u2019t a coherent function to name.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046902","count":2},{"id":"GO:0002534","count":1},{"id":"GO:0000348","count":1},{"id":"GO:0010255","count":1},{"id":"GO:0048568","count":1}]},{"hash":"403470635059075717","title":"GTPase-driven synaptic signaling and actin remodeling","description":"This cluster centers on small GTPase\u2013mediated signaling and actin cytoskeleton dynamics (filopodium assembly, regulation of filopodium), with supporting synaptic transmission (GABAergic) and GPCR signaling (tachykinin). Mitochondrial fission indicates organelle dynamics linked to cellular signaling, while muscle contraction terms appear as broader context rather than core to the cluster. Overall, the dominant theme ties together signaling with cytoskeletal remodeling at synapses.","confidence":"Medium","size":8,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051932","count":3},{"id":"GO:0000266","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0046847","count":3},{"id":"GO:1900026","count":3}]},{"hash":"1847967732845175920","title":"Retroelement Transposition and Proviral Integration","description":"The GO terms are dominated by DNA integration, transposition (DNA and retrotransposition), and RNA-templated DNA synthesis, all hallmark steps of mobile genetic elements such as transposons and retroviruses. Additional terms about symbiont entry into host cells and proviral latency reinforce a theme of viral or transposon-mediated genome modification and integration. Together, the cluster appears to reflect activities related to mobilizing and integrating genetic material rather than a single metabolic function.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":3}]},{"hash":"1147448201604242232","title":"Unknown","description":"The GO terms span immune signaling (LPS response, IL-18 production, antibacterial peptide biosynthesis), autophagy and ubiquitination regulation, signaling cascades, and distinct developmental/neural processes (EPSP regulation, tangential migration to the olfactory bulb, otolith morphogenesis). There isn\u2019t a single coherent functional theme linking all eight proteins, so a concise, unified label isn\u2019t supported.","confidence":"","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090394","count":3},{"id":"GO:0022028","count":3},{"id":"GO:0032474","count":3},{"id":"GO:0006963","count":3},{"id":"GO:0016239","count":3}]},{"hash":"1339400932542493542","title":"Long-chain fatty acid metabolism and transport","description":"Most top GO terms cluster around long-chain fatty acid metabolism, including import/export and fatty-acyl-CoA processing, indicating a fatty acid handling/transport role. A few terms tie to seed/phenylpropanoid pathways, which may reflect plant-specific lipid biology, but the fatty-acid theme dominates.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019654","count":4},{"id":"GO:0090410","count":4},{"id":"GO:0001676","count":4},{"id":"GO:0044539","count":4},{"id":"GO:0019629","count":4}]},{"hash":"2211786079862661674","title":"Mitochondrial redox and oxidative stress response","description":"This cluster is dominated by GO terms for redox balance, oxidative stress response, and mitochondrial electron transport (e.g., cellular redox homeostasis, cellular response to oxidative stress, and mitochondrial electron transport). These indicate proteins involved in mitochondrial energy production coupled with antioxidant defenses. A few terms related to nucleotide biosynthesis and ion/stress responses are present but seem secondary to the core redox/mitochondrial theme. Overall, the cluster centers on redox regulation and mitochondrial function.","confidence":"High","size":8,"edges":26,"triangles":45,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0045454","count":3},{"id":"GO:0030416","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0006122","count":2}]},{"hash":"1292925216931153758","title":"Neurodevelopmental chromatin regulation","description":"Top terms show multicellular organism development and midbrain development, combined with transcriptional and epigenetic control (negative regulation of RNA polymerase II transcription, DNA methylation and histone methylation, heterochromatin formation). This suggests proteins functioning in neural development through epigenetic regulation of gene expression.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0030901","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0000414","count":1},{"id":"GO:0051096","count":1}]},{"hash":"1815388894499131874","title":"Ubiquitin-Driven Immune Signaling and Apoptosis Control","description":"The cluster\u2019s top GO terms converge on immune defense (adaptive immune response, defense against virus) and signaling pathways (NF-kappaB) with tight regulation of cell fate (negative regulation of apoptosis, necroptosis, cell cycle) and protein turnover (ubiquitination, protein destabilization). This points to a set of proteins that coordinate immune signaling via ubiquitin-mediated regulation of apoptosis and related cell fate decisions, rather than a single metabolic function.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043066","count":3},{"id":"GO:0016567","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0002250","count":2}]},{"hash":"1535758839844552536","title":"Cell polarity and cytoskeletal dynamics in development","description":"The dominant GO terms describe cellular architecture\u2014cell polarity, epithelial adhesion, and actin cytoskeleton reorganization\u2014along with intracellular trafficking (ER-Golgi) and wing development cues, with some neuronal signaling terms suggesting synaptic organization. Together these point to a theme of cellular organization underlying development and neural connectivity, justifying the chosen label.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050975","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0048169","count":2},{"id":"GO:0007476","count":2},{"id":"GO:0006888","count":2}]},{"hash":"2252139595800218791","title":"Embryonic development and morphogenesis","description":"These proteins cluster around developmental and morphogenetic processes, including endocrine system development, pancreatic cell development, cartilage morphogenesis, left-right pattern formation, and EMT-related endocardial cushion formation, suggesting a theme of embryogenesis and tissue differentiation. Some terms reflect general cellular machinery (splicing, ribosomal export), but the dominant signal is embryonic development and organogenesis.","confidence":"High","size":8,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0035270","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0060536","count":2}]},{"hash":"1187350629095128833","title":"ECM remodeling and cell migration regulation","description":"The top terms cluster around proteolysis and regulation of cell adhesion and migration (integrin-mediated adhesion, keratinocyte/lymphocyte migration, fibronectin-dependent thymocyte migration), plus related ECM turnover (proteoglycan catabolic process). This suggests a theme of extracellular matrix remodeling linked to coordinated cell movement, common in skin and immune contexts. However, the mix with differentiation regulation makes the theme broad rather than a single precise pathway.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0045636","count":2},{"id":"GO:0033630","count":2},{"id":"GO:2001113","count":2},{"id":"GO:0032331","count":2}]},{"hash":"270526130764119504","title":"Developmental growth and organ patterning","description":"The top GO terms center on skin development, embryonic organ development, and pattern formation, pointing to a developmental and growth-regulation theme. Additional terms touch on growth hormone response and adaxial/abaxial patterning, suggesting tissue organization during development. A few terms (rRNA maturation, peroxisome targeting, actin nucleation regulation) reflect general cellular processes that may be incidental. Overall, the dominant signal is developmental growth and patterning. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0034316","count":3},{"id":"GO:0002534","count":2},{"id":"GO:0000348","count":2},{"id":"GO:0010255","count":2}]},{"hash":"574282017059787976","title":"Leukocyte adhesion and migration","description":"The top terms point to immune cell adhesion, integrin signaling, and extravasation (cell adhesion, integrin signaling, cellular extravasation), with supporting roles in T cell activation and antigen processing (T cell activation via TCR, ubiquitin-dependent proteolysis, proteasome assembly) and extracellular matrix remodeling. Together, these suggest a cluster of proteins involved in leukocyte adhesion to endothelium and subsequent migration during immune responses.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:1901202","count":4},{"id":"GO:1905050","count":4},{"id":"GO:0002291","count":4},{"id":"GO:0006511","count":4},{"id":"GO:0070208","count":4}]},{"hash":"1650716807728659678","title":"RNA processing and translation initiation","description":"The GO terms converge on RNA processing and gene expression, including transcription, mRNA splicing, and formation of the translation preinitiation complex, with an additional vesicle transport term linking to protein trafficking. Some other terms (apoptosis, DNA transposition) seem less central here, so the core theme is RNA processing and early steps of protein synthesis. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0000132","count":2},{"id":"GO:0006351","count":2}]},{"hash":"752233349387602584","title":"Purine Nucleoside Salvage and Catabolism","description":"The proteins in this cluster are linked by nucleotide metabolism: multiple GO terms point to purine ribonucleoside salvage, uridine/UMP/uridine catabolism, inosine and deoxyguanosine catabolism, and purine interconversion. A single host-defense perturbation term appears incidental to the core metabolic theme. Overall, the cluster represents purine and nucleoside salvage/catabolic pathways.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":1},{"id":"GO:0006148","count":1},{"id":"GO:0006166","count":1},{"id":"GO:0006161","count":1},{"id":"GO:0042149","count":1}]},{"hash":"735353825765722829","title":"Endosomal MVB Sorting and Vacuolar Transport","description":"The dominant GO terms point to multivesicular body (MVB) assembly and vacuolar protein transport via MVB sorting, along with endosome regulation and trafficking. While there are additional terms (mitotic exit, lens maintenance) that suggest broader roles, the core theme is endosomal/MVB-mediated trafficking to the vacuole.","confidence":"High","size":8,"edges":9,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1904669","count":2},{"id":"GO:0030447","count":2},{"id":"GO:0010458","count":2},{"id":"GO:0036258","count":2},{"id":"GO:0043328","count":2}]},{"hash":"879469096798371624","title":"Unknown","description":"The top GO terms span diverse biology\u2014from methylation and stress response to reproductive development (prostate growth, sex differentiation, maternal parturition), lipid metabolism, prostaglandin and calcitriol biosynthesis, and even microbial antibiotic biosynthesis\u2014showing no single cohesive function. With only a couple of edges among eight proteins, there isn\u2019t a clear shared pathway or theme to tie the cluster together.","confidence":"","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032259","count":8},{"id":"GO:0035902","count":8},{"id":"GO:0060736","count":7},{"id":"GO:0033072","count":7},{"id":"GO:0036378","count":7}]},{"hash":"1659932769200104434","title":"Cytochrome P450\u2013driven lipid and steroid metabolism","description":"The top GO terms cluster around P450-related pathways: omega-hydroxylase and epoxygenase P450 pathways, prostaglandin and calcitriol biosynthesis, and triglyceride metabolism. These collectively point to cytochrome P450\u2013mediated lipid and steroid metabolism. Some reproductive development terms (sex differentiation, prostate growth, maternal parturition) can be linked to hormone signaling and lipid-derived mediators, supporting a cohesive theme despite some breadth. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046232","count":7},{"id":"GO:0060736","count":5},{"id":"GO:0033072","count":5},{"id":"GO:0036378","count":5},{"id":"GO:0097267","count":5}]},{"hash":"2292203715513656914","title":"GPCR-Mediated Neuroendocrine Signaling","description":"The cluster shows GO terms tied to GPCR-driven signaling and hormone responses, including dopamine receptor signaling (adenylate cyclase pathway), glucagon- and prostaglandin-responsive signaling, and regulation of insulin secretion, plus sensory and balance-related processes (smell and neuromuscular balance) and a link to the secretory pathway (ER to Golgi transport). This suggests a cohesive theme around neuroendocrine GPCR signaling and secretion rather than unrelated functions.","confidence":"Medium","size":8,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0006355","count":1},{"id":"GO:0061178","count":1},{"id":"GO:0050885","count":1},{"id":"GO:0071377","count":1}]},{"hash":"1106684417340070922","title":"Amino acid biosynthesis and aromatic compound catabolism","description":"Most of the GO terms cluster around nitrogen and sulfur assimilation (nitrate assimilation, sulfate assimilation, L-cysteine biosynthetic), plus catabolic processes for aromatic compounds (phenylacetate and toluene catabolism), suggesting a metabolic module focused on amino acid production and degradation of aromatic substrates. A few terms related to nitric oxide regulation and immune signaling appear unrelated to the core metabolism, making the signal for a cohesive function moderate rather than strong.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0045429","count":1},{"id":"GO:0042128","count":1},{"id":"GO:0000103","count":1},{"id":"GO:0043154","count":1},{"id":"GO:0072606","count":1}]},{"hash":"400201580642527443","title":"Lipid remodeling and cholesterol homeostasis","description":"Most GO terms cluster around lipid metabolism, including lipid digestion, triglyceride catabolic process, HDL/VLDL particle remodeling, triglyceride/triglyceride-related processes, cholesterol homeostasis, and reverse cholesterol transport, suggesting a lipid metabolism and cholesterol transport theme. Some terms (adult somatic muscle development, regulation of thiamine biosynthesis, glycolytic fermentation to ethanol) are less consistent and may reflect annotation noise.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903212","count":2},{"id":"GO:0090180","count":2},{"id":"GO:0007527","count":2},{"id":"GO:2001172","count":2},{"id":"GO:0044241","count":1}]},{"hash":"305716703268796240","title":"Immune activation and leukocyte signaling","description":"The top GO terms emphasize neutrophil extravasation, IL-4\u2013mediated response, and lymphocyte proliferation, pointing to immune cell activation and signaling as the core theme. Some other terms (e.g., GTP biosynthesis, fatty acid oxidation, glycolate catabolism, glutamate biosynthesis) appear as metabolic annotations that may be incidental or reflect shared housekeeping functions across species; nevertheless, the repeated immune-related terms dominate, supporting a label tied to immune cell regulation rather than a strictly metabolic cluster.","confidence":"Medium","size":8,"edges":9,"triangles":2,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:2000391","count":4},{"id":"GO:0009854","count":3},{"id":"GO:0071353","count":3},{"id":"GO:0080114","count":3},{"id":"GO:0046651","count":3}]},{"hash":"1941874342363931087","title":"Cell Stress and Metabolism","description":"Proteins in this cluster carry GO terms spanning stress responses (response to cold, response to xenobiotic stimulus, apoptotic process) and diverse metabolic processes (tetrahydrofolate metabolism, amino-acid catabolic pathways, tRNA wobble base modification). The common theme appears to be cellular stress response with metabolic adjustment, though the terms are broad and not tightly cohesive.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009409","count":3},{"id":"GO:0010725","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0002097","count":3},{"id":"GO:0006579","count":3}]},{"hash":"1075101230800714080","title":"Unknown","description":"The top GO terms are inconsistent and many are obsolete; the remaining terms span unrelated processes (unfolded protein response, morphine response, fat pad and prostate development, plant hormone signaling), providing no single cohesive function for the cluster.","confidence":"","size":8,"edges":8,"triangles":0,"max_degree":4,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:1901215","count":3},{"id":"GO:0035955","count":3},{"id":"GO:0043278","count":3},{"id":"GO:0006986","count":3},{"id":"GO:0045842","count":3}]},{"hash":"646549913259892320","title":"Stress-response signaling and innate immunity","description":"These proteins cluster around stress and immune signaling: responses to heat/cold, detection of chemical stimuli linked to pain, GPCR- and NOD1-mediated signaling, and processes like ubiquitination and myeloid apoptosis. While adipocyte differentiation and cardiac electrical signaling appear, the common thread is stress-related signaling and innate immune pathways. Therefore the name reflects the dominant themes in the GO terms. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":4},{"id":"GO:0098907","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0009409","count":3},{"id":"GO:0009408","count":3}]},{"hash":"953616301661266937","title":"Embryonic Development and Tissue Differentiation","description":"The GO terms cluster around embryonic and organ development\u2014endocrine system development, placental/pancreatic cell development, cartilage morphogenesis, left-right patterning, and EMT\u2014suggesting the proteins participate in early differentiation programs across tissues. While transcription and splicing terms appear, they likely reflect general expression machinery rather than a single function.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0060536","count":5},{"id":"GO:0003198","count":5}]},{"hash":"1856398610927662024","title":"Diverse membrane solute transporters","description":"The GO terms cluster around transmembrane transport of a wide range of solutes (nitrate/nitrite, sugars, vitamins, phosphate, sialic acid, hydroxyphenylacetate, etc.), so these proteins likely function as membrane transporters with broad substrate scope.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":8},{"id":"GO:0015739","count":8},{"id":"GO:0042891","count":8},{"id":"GO:0035435","count":8},{"id":"GO:0035461","count":8}]},{"hash":"1961580433132401372","title":"Lipid biosynthesis and fatty acid metabolism","description":"The top GO terms are centered on lipid-related processes, including methyl-branched fatty acid biosynthesis, fatty acid elongation, mycolic acid biosynthesis, and various lipid catabolic pathways (e.g., 3-keto-sphinganine, acetoin, propylene). While there are a few miscellaneous terms (transcription regulation, retinal metabolism), the lipid biosynthesis/catabolism signals dominate, justifying a lipid-focused label.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:1902321","count":3},{"id":"GO:0006706","count":3},{"id":"GO:0006729","count":3},{"id":"GO:0045150","count":3}]},{"hash":"1928215881007501043","title":"Mitotic Progression and Kinetochore Localization","description":"The top GO terms are dominated by cell cycle and replication processes (G1/S transition, G2/M transition, DNA replication, meiotic cell cycle) and by protein localization to the kinetochore, pointing to a cluster of proteins involved in mitotic progression and chromosome segregation. The presence of terms related to neural development and inflammatory regulation appears ancillary, suggesting these GO terms may reflect multi-functional annotations rather than core cluster function.","confidence":"Medium","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000082","count":7},{"id":"GO:0034501","count":6},{"id":"GO:0042220","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0014044","count":6}]},{"hash":"807348329869653139","title":"Ubiquitin\u2013Proteasome Regulation of Mitosis","description":"The cluster is dominated by terms tying protein ubiquitination/deubiquitination to proteasome assembly and mitotic control (G2/M, APC-dependent degradation), indicating a core theme of ubiquitin-proteasome\u2013mediated regulation of cell cycle progression. Some terms (viral process, Fc-epsilon receptor signaling) may reflect broader ubiquitin signaling interactions rather than a strict mitotic function, but the strongest signals point to mitosis control via protein turnover.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":6},{"id":"GO:0031145","count":4},{"id":"GO:0016032","count":4},{"id":"GO:0038095","count":4},{"id":"GO:0051437","count":4}]},{"hash":"669262232706828583","title":"Developmental morphogenesis and cytoskeletal regulation","description":"This cluster centers on embryonic development and tissue morphogenesis (embryonic body morphogenesis, cranial skeletal system development, renal development) and involves cytoskeletal dynamics (intermediate filament bundle assembly, actin cytoskeleton regulation) with related processes like EMT modulation, indicating proteins that coordinate shape change and differentiation during development.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048364","count":5},{"id":"GO:0007050","count":4},{"id":"GO:0045110","count":3},{"id":"GO:0010172","count":3},{"id":"GO:0072054","count":3}]},{"hash":"2063275019043214010","title":"RNA Pol II Transcription Repression and DNA Binding Regulation","description":"Based on the dominant terms, the cluster shows enrichment for negative regulation of transcription by RNA polymerase II and related regulation of DNA binding, with additional signals of kinase activity modulation. Although a few terms touch on development or host-virus interactions, the strongest theme is transcriptional control and DNA-binding regulation, suggesting the proteins function in transcriptional regulation processes.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:1900363","count":2},{"id":"GO:0044829","count":2},{"id":"GO:1901407","count":2},{"id":"GO:0043388","count":2}]},{"hash":"515020874885076947","title":"mRNA processing and stability regulation","description":"The top GO terms cluster around mRNA maturation and turnover, including regulation of polyadenylation, spliceosome-driven splicing (including alternative splicing), and mRNA stabilization, especially in response to stress. A translational initiation term related to IRES also ties to RNA handling. Together these terms point to a functional group centered on post-transcriptional RNA processing and stability control.","confidence":"High","size":7,"edges":16,"triangles":13,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":5},{"id":"GO:0010610","count":5},{"id":"GO:0045292","count":3},{"id":"GO:1900363","count":3},{"id":"GO:0000381","count":3}]},{"hash":"1384609816644402507","title":"Neurodevelopmental Signaling and Axon Guidance","description":"The top GO terms are largely about neural development and guidance (neural tube patterning, nervous system development, axon extension, Roundabout/ROBO signaling, and Smoothened/SHH signaling), indicating the proteins likely participate in neural patterning and neuronal connectivity. A few non-neural terms (T cell receptor signaling, engulfment of apoptotic cell, Golgi organization) may reflect shared cellular components or annotation noise, but the dominant theme points to neurodevelopment and axon guidance.","confidence":"Medium","size":7,"edges":14,"triangles":9,"max_degree":5,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0050852","count":4},{"id":"GO:0043652","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0045773","count":4}]},{"hash":"1029713462319475620","title":"Unknown","description":"The top GO terms are spread across DNA integration, RNA splicing, muscle development regulation, and larval lymph gland hemopoiesis, with no single cohesive function linking the proteins. Therefore, a meaningful, specific label cannot be assigned.","confidence":"","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0006376","count":1},{"id":"GO:0045843","count":1},{"id":"GO:0035167","count":1}]},{"hash":"113071339282738414","title":"Neuronal signaling and sensory perception","description":"The top GO terms cluster around sensory processing (touch and pain) and neural signaling, including excitatory postsynaptic potentials and regulation of activity, suggesting proteins involved in neuronal communication and sensory modulation. While a few terms are broader or deprecated, the prevailing theme points to neural signaling and sensory perception activities.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0010226","count":5},{"id":"GO:0060992","count":5},{"id":"GO:0050975","count":5},{"id":"GO:0065009","count":5},{"id":"GO:0032781","count":5}]},{"hash":"256348651920528138","title":"RNA Splicing and mRNA Export","description":"The dominant GO terms point to spliceosome-mediated mRNA processing (splicing and alternative splicing) and mRNA export from the nucleus, with an additional signal for mRNA localization and polyadenylation regulation, indicating a cohesive role in RNA maturation and trafficking; the other terms appear secondary context (stimulus responses, translation) to this core function.","confidence":"High","size":7,"edges":6,"triangles":4,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000381","count":4},{"id":"GO:0006406","count":4},{"id":"GO:0045451","count":4},{"id":"GO:0002931","count":3},{"id":"GO:0045292","count":3}]},{"hash":"1900687184165715781","title":"Ciliary Hedgehog signaling in neural and eye development","description":"The terms center on cilium-related processes (receptor localization to non-motile cilium) and Hedgehog signaling via Smoothened, linked to dorsal/ventral neural tube patterning and embryonic eye development, with additional developmental terms like ganglion and bone development supporting a ciliopathy/developmental theme. The 7-methylguanosine mRNA capping term is general and less informative but does not contradict the core connection. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":2},{"id":"GO:0006910","count":1},{"id":"GO:0006909","count":1},{"id":"GO:0050766","count":1},{"id":"GO:0061548","count":1}]},{"hash":"1671768347235852036","title":"DNA Repair and Mitotic Regulation","description":"The cluster centers on DNA damage response and cell-cycle control, with multiple terms for nucleotide-excision repair, G2/M transition, chromosome segregation, mitotic exit, and ubiquitin-dependent proteolysis, plus chiasma assembly and apoptosis. The presence of viral process and interferon signaling suggests additional antiviral stress context, but the core signal remains genome maintenance and mitosis regulation.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0070911","count":7},{"id":"GO:0016032","count":7},{"id":"GO:0000086","count":7},{"id":"GO:0007059","count":7},{"id":"GO:0010458","count":7}]},{"hash":"605330618160060236","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0048568","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0000463","count":2}]},{"hash":"1878421822482936387","title":"Developmental Regulation and Morphogenesis","description":"The top GO terms cluster around developmental processes and morphogenesis across multiple tissues (ectoderm, forebrain, reproductive tract) and include regulatory pathways (Hippo signaling, miRNA silencing) that modulate development. This combination suggests a general theme of developmental regulation and morphogenesis rather than a single tissue-specific function.","confidence":"High","size":7,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035331","count":7},{"id":"GO:2000691","count":7},{"id":"GO:2000637","count":7},{"id":"GO:0035847","count":7},{"id":"GO:0046013","count":7}]},{"hash":"1569141915161383523","title":"Germline development and proteostasis","description":"Most dominant GO terms relate to germline development (germarium-derived cystoblast division; male germ-line cyst encapsulation) and protein turnover/translation (ubiquitin-dependent proteolysis; formation of cytoplasmic translation initiation complex). This suggests a cluster focused on germline development with associated proteostasis and translation regulation, though a few terms (e.g., neuron differentiation) may be less directly related.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000973","count":1},{"id":"GO:0048142","count":1},{"id":"GO:0001732","count":1},{"id":"GO:0030182","count":1},{"id":"GO:0048140","count":1}]},{"hash":"1744548899817763827","title":"Unknown","description":"The top terms span transcription regulation, apoptosis, immune response, neural regeneration, differentiation, development, nutrient signaling, aging, and cardiac signaling, with no single cohesive theme linking all proteins. Because a unifying function is not evident, the cluster is labeled Unknown.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903655","count":2},{"id":"GO:0097194","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0048679","count":2},{"id":"GO:0045444","count":2}]},{"hash":"1929789478968898340","title":"Neural crest migration and axon guidance","description":"The GO terms point to neural crest\u2013derived tissue development and axon guidance: neural crest migration (ventral trunk neural crest cell migration), various neuron projection guidance (sympathetic neuron projection guidance, branchiomotor neuron axon guidance, trigeminal nerve organization), and axonal fasciculation, plus related signaling pathways (semaphorin-plexin and Smoothened signaling) that coordinate these processes. This combination suggests a coherent theme of guiding nerve growth and neural crest\u2013driven patterning in the developing peripheral nervous system.","confidence":"High","size":7,"edges":7,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030913","count":3},{"id":"GO:0007166","count":3},{"id":"GO:0021637","count":2},{"id":"GO:0097491","count":2},{"id":"GO:0097490","count":2}]},{"hash":"2273584058140010039","title":"Glycerophospholipid Biosynthesis","description":"The cluster centers on membrane lipid metabolism, as shown by multiple GO terms for biosynthesis of phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, and phosphatidylinositol, plus related lipid signaling terms like platelet activating factor biosynthesis and response to phosphatidylethanolamine. These converge on a cohesive theme of glycerophospholipid production and membrane lipid dynamics, with only a couple outliers that do not alter the overall interpretation.","confidence":"High","size":7,"edges":15,"triangles":13,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006646","count":2},{"id":"GO:0070317","count":2},{"id":"GO:0010512","count":2},{"id":"GO:1905711","count":2},{"id":"GO:0006659","count":2}]},{"hash":"280358485033006502","title":"Unknown","description":"The Top Terms mix vertebrate developmental processes (central nervous system development, glomerular basement membrane development, chondrocyte development, innervation, glial signaling) with bacterial biosynthesis (lipoteichoic acid and choline biosynthesis) and signaling regulation (FGFR pathway), which do not point to a coherent single function or pathway across the proteins. Because of this heterogeneity, a concise, representative label cannot be confidently assigned.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070395","count":4},{"id":"GO:0002063","count":3},{"id":"GO:0032836","count":3},{"id":"GO:0035860","count":3},{"id":"GO:0040037","count":3}]},{"hash":"1444438568433779761","title":"Cardiac development and calcium-regulated contraction","description":"GO terms predominantly describe cardiac development and heart muscle contraction regulation, including left ventricle morphogenesis, outflow tract morphogenesis, SA node function, and calcium-release\u2013dependent regulation of contraction, implying a heart development/function cluster. Some terms like skin development and caffeine/epinephrine response are less central but do not negate the cardiac theme.","confidence":"High","size":7,"edges":7,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0071872","count":3},{"id":"GO:0098907","count":3},{"id":"GO:0071313","count":3}]},{"hash":"321268341478103733","title":"Genome stability and telomere maintenance","description":"Top terms converge on telomere maintenance and genome integrity, including DNA replication, DNA repair, and DNA recombination, with protein localization to telomeres. Although mitochondrial tRNA aminoacylation terms appear among the top annotations, the shared theme across most terms centers on telomere maintenance and genome stability.","confidence":"Medium","size":7,"edges":7,"triangles":1,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0010833","count":3},{"id":"GO:0070154","count":3},{"id":"GO:0070146","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0072581","count":3}]},{"hash":"1506151953059537188","title":"Auditory Neuron Signaling and Cochlear Development","description":"The GO terms cluster around neuronal excitability and synaptic transmission in auditory pathways\u2014membrane depolarization, excitatory and inhibitory postsynaptic potentials, and sensory perception of sound\u2014titting with cochlear development. While some terms touch broader neuronal processes (neuroprotection, drug response), the dominant theme is hearing-related neural signaling and inner-ear development.","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051899","count":3},{"id":"GO:1905906","count":3},{"id":"GO:0060080","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0090102","count":3}]},{"hash":"1526471439924211002","title":"DNA Damage Response and Transcription Regulation","description":"These proteins appear to participate in genome maintenance and transcription control, with GO terms centering on DNA damage response and repair (nucleotide-excision repair, translesion synthesis, UV-C response) and DNA-templated processes, along with transcription regulation components (preinitiation complex assembly). The combination suggests a coordinated role in repairing DNA damage while regulating transcription in response to that damage.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043966","count":2},{"id":"GO:0070987","count":2},{"id":"GO:0071494","count":2},{"id":"GO:0006297","count":2},{"id":"GO:0042276","count":2}]},{"hash":"1433827311053944275","title":"Meiosis and Chromatin Regulation","description":"Top terms center on chromatin and meiosis: chiasma assembly and heterochromatin formation, plus histone modification terms. A few terms are generic or obsolete, but the core signal is meiosis-associated chromatin regulation, so the label fits the cluster.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0051026","count":7},{"id":"GO:0033128","count":7},{"id":"GO:0006915","count":7},{"id":"GO:0060340","count":7},{"id":"GO:0016562","count":7}]},{"hash":"1660388900927654111","title":"Cytochrome P450\u2013driven lipid and hormone metabolism","description":"This cluster is dominated by GO terms pointing to cytochrome P450\u2013mediated pathways involved in lipid and hormone biosynthesis/metabolism, including omega-hydroxylase and epoxygenase P450 routes, prostaglandin and calcitriol biosynthesis, and triglyceride metabolism, with related terms on sex differentiation and maternal reproductive processes, suggesting a cohesive role in hormone-related lipid metabolism.","confidence":"High","size":7,"edges":18,"triangles":22,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0046232","count":6},{"id":"GO:0060736","count":5},{"id":"GO:0033072","count":5},{"id":"GO:0036378","count":5},{"id":"GO:0097267","count":5}]},{"hash":"1840143302882730390","title":"Embryonic craniofacial and neural morphogenesis","description":"The top GO terms cluster around early embryonic development, especially ectoderm formation and craniofacial structures (roof of mouth development, skeletal system development), as well as neural development (cerebral cortex regionalization, spinal interneuron specification, glial differentiation). While there are a few kidney-related terms, the dominant signal is embryonic morphogenesis in ectoderm-derived tissues and neural/craniofacial patterning, suggesting the proteins function together in early developmental processes shaping head, brain, and associated organs.","confidence":"High","size":7,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":3},{"id":"GO:0048557","count":2},{"id":"GO:0035623","count":2},{"id":"GO:0021913","count":2},{"id":"GO:0045686","count":2}]},{"hash":"1114981454165792227","title":"Unknown","description":"The listed GO terms cover a wide mix of functions\u2014from mRNA capping and dimethylation to cofactor biosynthesis and stress responses\u2014without a clear shared pathway or functional theme linking the proteins. With no edges or cohesive enrichment, there isn\u2019t a confident, representative label to assign beyond Unknown.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":1},{"id":"GO:0006744","count":1},{"id":"GO:0035572","count":1},{"id":"GO:0006972","count":1},{"id":"GO:0042372","count":1}]},{"hash":"1945070642154155029","title":"Developmental differentiation and morphogenesis","description":"The top GO terms show differentiation processes (myoblast differentiation; spongiotrophoblast differentiation) and organ morphogenesis (notum morphogenesis; left ventricular cardiac muscle tissue morphogenesis) dominating the set, suggesting a cluster tied to developmental programs. Some signaling and apoptosis regulation terms appear but are secondary to the differentiation/morphogenesis theme. Confidence: Medium","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001778","count":2},{"id":"GO:0071638","count":1},{"id":"GO:0048802","count":1},{"id":"GO:0045445","count":1},{"id":"GO:0035372","count":1}]},{"hash":"1748669356889480424","title":"Mixed catabolic and detoxification processes","description":"The proteins show a mix of diverse catabolic and detoxification GO terms (various substrate catabolisms, xenobiotic detoxification, P450-related pathways), with no single dominant function, indicating a cluster of broadly metabolic/detox roles rather than a specific pathway.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":2},{"id":"GO:0019260","count":1},{"id":"GO:0019433","count":1},{"id":"GO:0098869","count":1},{"id":"GO:0019391","count":1}]},{"hash":"2271513828672830652","title":"Retroviral DNA Integration and Latency","description":"The dominant terms describe retroviral steps: entry into host cell, penetration into the host nucleus, and integration of proviral DNA with latency. Although a few neural development terms appear, they are less representative; overall the cluster centers on retroviral integration and latency.","confidence":"High","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0039651","count":2}]},{"hash":"867941842802228697","title":"Ciliary Basal Body Organization and Morphogenesis","description":"Most GO terms point to developmental morphogenesis (e.g., post-anal tail morphogenesis, convergent extension) and cilia/microtubule organization (ciliary basal body organization, protein localization to microtubule). There are also signaling and stabilization roles (tyrosine kinase/JNK regulation, Wnt-related pathway). This suggests a cohesive theme centered on ciliogenesis/microtubule-driven morphogenesis during development.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036342","count":1},{"id":"GO:0032053","count":1},{"id":"GO:0061098","count":1},{"id":"GO:0043507","count":1},{"id":"GO:0050821","count":1}]},{"hash":"1031292541358702224","title":"RNA and protein methylation","description":"The top GO terms are dominated by methylation-related processes: tRNA methylation, rRNA methylation, 7-methylguanosine mRNA capping, and protein methylation, suggesting the proteins function as methyltransferases or in methylation regulation. Other terms (ubiquinone/biotin biosynthesis, chlorophyll biosynthesis, nodulation, tellurium response) are more divergent and may reflect broader annotations or multifunctionality. Overall, the shared theme is methylation-focused activity, making this a coherent label, though some terms are less directly connected. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090398","count":4},{"id":"GO:0030488","count":4},{"id":"GO:0031167","count":4},{"id":"GO:0006370","count":3},{"id":"GO:0006479","count":3}]},{"hash":"791315320682423319","title":"Signaling and Vesicle Trafficking","description":"This cluster combines clear signaling pathway terms (T cell receptor signaling, Wnt signaling) with multiple vesicle trafficking processes (ER\u2013Golgi and Golgi\u2013ER transport, endocytosis, vacuole targeting), suggesting proteins that mediate signaling events in concert with intracellular transport. Some terms relate to development and cell cycle, but the dominant pattern is signaling plus vesicular transport.","confidence":"Medium","size":6,"edges":6,"triangles":2,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":4},{"id":"GO:0090263","count":4},{"id":"GO:0006623","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0006890","count":3}]},{"hash":"1272653351557378434","title":"Neuronal development and synapse formation","description":"The cluster\u2019s top GO terms are dominated by neuron development, regulation of axon regeneration, and protein localization to synapse, with supporting signaling terms like integrin-mediated signaling and polarity establishment. This points to a core theme around neuronal development and synapse organization, even though a few terms (like insulin signaling or bone mineralization) are broader contextual connections. ","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048666","count":3},{"id":"GO:0032435","count":3},{"id":"GO:0048679","count":3},{"id":"GO:0007229","count":3},{"id":"GO:2000114","count":3}]},{"hash":"696917280937899464","title":"Ubiquitin-Mediated Transcriptional Regulation & Degradation","description":"The GO terms cluster around ubiquitination (protein ubiquitination, autoubiquitination, ubiquitin-dependent protein catabolic process) and transcriptional regulation (negative regulation of transcription by RNA polymerase II), with a stress-response cue (cellular response to hydrogen peroxide), pointing to a role in ubiquitin-mediated control of protein turnover and transcription.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0051865","count":4},{"id":"GO:1903265","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0070301","count":4}]},{"hash":"39182549190481628","title":"Glutamatergic synapse signaling and plasticity","description":"The cluster is enriched for neural synapse-related processes: positive regulation of glutamatergic synaptic transmission, NMDA receptor activity regulation, long-term potentiation, and dendritic spine morphogenesis, plus reelin-mediated signaling and receptor localization to the synapse. These terms point to a coherent theme of excitatory synaptic signaling and plasticity, with a neuronal development angle (neuron migration). Some terms like angiogenesis and protozoan defense appear as background noise but don\u2019t dominate the theme. ","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0014068","count":2},{"id":"GO:0038026","count":2},{"id":"GO:1900273","count":2},{"id":"GO:0042832","count":2}]},{"hash":"1802512177228869215","title":"Neural development and vesicle trafficking","description":"The top GO terms center on brain development and neural components (brain development, substantia nigra development) along with synaptic function (GABAergic transmission) and vesicle trafficking processes (COPII-coated vesicle budding, retrograde Golgi-ER transport) and growth-related regulation (filopodium assembly). This suggests a cohesive theme of neural development coordinated with vesicle transport and synaptic activity, despite a few outlier mitotic terms likely reflecting developmental context rather than core function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0051932","count":2},{"id":"GO:0090114","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0021762","count":2}]},{"hash":"16190338846884671","title":"Ribosome biogenesis and translation","description":"The top GO terms cluster around ribosome assembly, cytoplasmic translation, and SRP-dependent cotranslational targeting to membrane, indicating a core role in ribosome biogenesis and protein synthesis with membrane targeting. While some metabolic and immune signaling terms are present, the strongest signals point to ribosome-related processes.","confidence":"Medium","size":6,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032147","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0071353","count":1},{"id":"GO:0000027","count":1},{"id":"GO:0002181","count":1}]},{"hash":"156218888409718958","title":"Bacterial iron metabolism and tetrapyrrole biosynthesis","description":"The terms cluster around iron handling (detoxification of iron ion; siderophore-iron import) and tetrapyrrole biosynthesis (bacteriochlorophyll, regulation of tetrapyrrole metabolic processes). Positive regulation of succinate dehydrogenase activity also ties to respiratory/metabolic roles that depend on iron-containing enzymes. Some terms (neuronal synaptic plasticity, fibroblast proliferation) seem unrelated and likely represent annotation noise. ","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048169","count":2},{"id":"GO:1904234","count":1},{"id":"GO:1904231","count":1},{"id":"GO:1901401","count":1},{"id":"GO:1990461","count":1}]},{"hash":"1303038249942163558","title":"Larval chitin-based cuticle development","description":"The GO terms show a clear focus on chitin-related processes, notably larval chitin-based cuticle development and chitin catabolic process, which point to insect cuticle formation and turnover as the core function of this cluster. The presence of carbohydrate metabolic process supports a link to chitin chemistry. Some terms related to splicing, cell cycle, and inflammatory mediators may be incidental annotations or reflect multifunctionality, but the dominant theme aligns with cuticle/chitin biology.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:1902455","count":1},{"id":"GO:2000825","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0000398","count":1}]},{"hash":"509500864483002510","title":"Nuclear RNA processing and transcription regulation","description":"The top GO terms point to nuclear roles in transcription control (RNA polymerase II) and post-transcriptional regulation (NMD, gene silencing) with some RNA processing activities (ribosome assembly). A few terms hint at stress responses, but the dominant theme appears to be nuclear RNA metabolism and transcriptional control, suggesting a coherent cluster around how RNA is produced, processed, and surveilled in the nucleus.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":2},{"id":"GO:0090394","count":1},{"id":"GO:0071039","count":1},{"id":"GO:0016584","count":1},{"id":"GO:0010225","count":1}]},{"hash":"498524469910226756","title":"Unknown","description":"The six proteins show a highly heterogeneous mix of GO terms (DNA transposition; rRNA maturation; peroxisome targeting; inflammatory cytokine production; glucose signaling; embryonic and skin development; pattern formation). There is no clear, shared function or pathway linking them, so a concise, representative cluster name cannot be assigned. ","confidence":"","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0002534","count":1},{"id":"GO:0000348","count":1},{"id":"GO:0010255","count":1}]},{"hash":"596775587025489574","title":"mRNA splicing and polyadenylation control","description":"The GO terms cluster around regulation of mRNA splicing via the spliceosome, plus processes governing polyadenylation, mRNA tail shortening, and mRNA stabilization, indicating a cohesive theme of post-transcriptional RNA processing and regulation. A single transport-related term appears minimally and does not define the cluster\u2019s main function.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0099132","count":1},{"id":"GO:0045292","count":1},{"id":"GO:1900363","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0060211","count":1}]},{"hash":"1530680407126313009","title":"Plant cell wall biogenesis and pectin glycosylation","description":"The terms are dominated by plant cell wall-related processes: plant-type secondary cell wall biogenesis, homogalacturonan and glucuronoxylan biosynthesis, and general cell wall organization, plus mucilage biosynthesis and galactose metabolism. The presence of protein O-linked glycosylation terms supports cell-wall associated glycoproteins. An outlier term about skeletal muscle regeneration seems incidental. Overall, the cluster points to plant cell wall biosynthesis and glycosylation components.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":3},{"id":"GO:0016266","count":3},{"id":"GO:0035269","count":3},{"id":"GO:0009834","count":3},{"id":"GO:0006012","count":3}]},{"hash":"538579692440317370","title":"Vacuolar Ion Homeostasis and Trafficking","description":"The GO terms cluster around vacuole-related processes (vacuolar organization, protein targeting to vacuole, vacuolar acidification) and ion/ proton transport (proton transmembrane transport, sodium ion transport, proton motive force-driven ATP synthesis) as well as copper ion homeostasis, suggesting a common theme of vacuole-mediated ion balance and trafficking. Some terms like autophosphorylation and lamellipodium morphogenesis are less clearly tied, but overall the set points to vacuolar function and ion regulation rather than a single enzyme complex.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006878","count":1},{"id":"GO:0006623","count":1},{"id":"GO:0006626","count":1},{"id":"GO:0007035","count":1},{"id":"GO:0015991","count":1}]},{"hash":"967345969766730398","title":"Ciliary assembly and Hedgehog signaling","description":"The cluster is dominated by cilium-related terms: cilium assembly and intraciliary transport, plus the smoothened signaling pathway, which together point to ciliary structure and Hedgehog signaling as a core function. Additional terms hint at broader developmental roles but are less central. This makes the ciliary signaling theme a concise and representative label.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060271","count":2},{"id":"GO:0007224","count":1},{"id":"GO:0042073","count":1},{"id":"GO:0002534","count":1},{"id":"GO:0000348","count":1}]},{"hash":"339467213871677678","title":"Neural development and axon guidance signaling","description":"Based on the prominent neural-related GO terms (nervous system development, brain development, Roundabout/ROBO signaling, smoothened/Hedgehog signaling, and regulation of synaptic vesicle exocytosis) this cluster appears to reflect neural development and associated signaling pathways. A few outlier terms (kidney development, T cell receptor signaling) suggest some mixed annotations, but the core theme centers on neural patterning and synaptic signaling.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":4},{"id":"GO:0001822","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0007224","count":4}]},{"hash":"1994121925592511756","title":"Translation and Ribosome Biogenesis","description":"The top GO terms are dominated by translation-related processes (translation, positive regulation of translation) and ribosomal large subunit biogenesis, suggesting the cluster mainly comprises components of the protein synthesis machinery. There are a few DNA damage response/transcription-related terms, but they are much less represented, indicating a secondary association rather than the primary function.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0006977","count":1},{"id":"GO:0006353","count":1},{"id":"GO:0045727","count":1},{"id":"GO:0042273","count":1}]},{"hash":"1892900408913645886","title":"mRNA Splicing and Poly(A) Regulation","description":"The top GO terms are dominated by mRNA processing functions: mRNA splicing via spliceosome, regulation of splicing, polyadenylation and tail shortening, and mRNA stabilization. This points to a coherent module centered on RNA maturation and control of transcript ends, with a minor note of viral translation terms that reflect RNA-centric regulation. Thus, a concise label capturing splicing and poly(A) regulation is appropriate.","confidence":"High","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":4},{"id":"GO:0045292","count":3},{"id":"GO:1900363","count":3},{"id":"GO:0000381","count":3},{"id":"GO:0060211","count":3}]},{"hash":"577476455405943075","title":"Retroviral entry, DNA integration, and latency","description":"Based on GO terms such as symbiont entry into host cell, viral penetration into host nucleus, establishment of integrated proviral latency, plus DNA integration and RNA-templated DNA biosynthetic processes, the cluster appears to capture the retroviral life cycle\u2014entry, reverse transcription, genome integration, and proviral latency in host cells.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":3}]},{"hash":"310389274774602743","title":"Viral Genome Integration and Latency","description":"The top GO terms point to viral infection and manipulation of the host genome: entry and penetration into the host cell and nucleus, integration of viral DNA into the host genome, establishment of proviral latency, and viral genome replication, along with transcriptional regulation of the host. This pattern suggests a cluster of proteins involved in viral integration and latency mechanisms.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2}]},{"hash":"134066220895984973","title":"Cellular stress and genome maintenance","description":"The top GO terms cluster around responses to xenobiotic stress, redox homeostasis, apoptosis, DNA repair, and regulation of mRNA stability, which together suggest a general cellular stress response with focus on genome integrity and survival. Some terms like lipopolysaccharide biosynthesis and corneocyte development seem less connected, likely noise, but the dominant theme centers on stress response and genome maintenance.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":3},{"id":"GO:0016311","count":2},{"id":"GO:0009103","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0090502","count":2}]},{"hash":"1705973121918896382","title":"Neural crest and cardiac development","description":"The provided GO terms predominantly represent differentiation and morphogenesis in neural crest\u2013derived lineages (carotid body glomus cells, oculomotor nerve, subpallial neurons) and heart-related processes (heart rate regulation, outflow tract morphogenesis, Notch involvement in heart induction). This shared theme suggests a cluster focused on neural crest\u2013driven development and cardiac formation.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0061103","count":5},{"id":"GO:0003062","count":5},{"id":"GO:2000820","count":5},{"id":"GO:0060165","count":5},{"id":"GO:0072277","count":5}]},{"hash":"224802048577577963","title":"Flowering Time Regulation and Inflorescence Development","description":"The top GO terms are dominated by plant reproductive development, including flower development, inflorescence development, photoperiodic flowering, and regulation of the vegetative-to-reproductive transition, indicating a cohesive theme around flowering control. Some other terms appear, but they are weaker signals compared to the flowering-related terms.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":1},{"id":"GO:0061026","count":1},{"id":"GO:0007018","count":1},{"id":"GO:0048510","count":1},{"id":"GO:0060409","count":1}]},{"hash":"297780812553682139","title":"RNA Pol II Transcription and RNA Processing","description":"Top GO terms cluster around RNA polymerase II transcription (elongation, termination, promoter start-site selection) and polyadenylation-associated RNA processing, with related themes of snoRNA transcription and transcription antitermination, suggesting a cohesive role in transcription and RNA maturation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":1},{"id":"GO:0030846","count":1},{"id":"GO:0001174","count":1},{"id":"GO:0030847","count":1},{"id":"GO:0006368","count":1}]},{"hash":"409290491509649099","title":"Ubiquitin-Proteasome System & Circadian Regulation","description":"The top GO terms center on ubiquitin-dependent protein catabolic processes and polyubiquitination, including SCF-dependent proteasomal degradation, strongly indicating a set of proteins involved in ubiquitin-proteasome\u2013mediated proteolysis. Circadian rhythm regulation and mitotic DNA damage checkpoint signaling terms suggest links to cell-cycle and circadian control via ubiquitination. While other terms hint at stress responses, the dominant theme is proteostasis through ubiquitin tagging and degradation, with a notable connection to circadian regulation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:1903378","count":3},{"id":"GO:0000209","count":3},{"id":"GO:1902916","count":3},{"id":"GO:0042752","count":3}]},{"hash":"1309843801282999587","title":"Retroviral entry, integration, and latency","description":"These GO terms cluster around steps in a retroviral lifecycle: entry into the host cell, penetration into the host nucleus, and establishment of integrated proviral latency, along with DNA integration and reverse transcription (RNA-templated DNA synthesis). The presence of DNA recombination also aligns with integration processes. Overall, the dominant theme is proviral entry and genome integration of a symbiont/virus.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0015074","count":2}]},{"hash":"1716514478007065468","title":"Methylation and chromatin regulation","description":"The cluster\u2019s top GO terms center on methylation events (rRNA methylation; peptidyl-lysine dimethylation; N-terminal peptidyl-glycine methylation) and chromatin-related processes (rDNA heterochromatin formation), suggesting a set of proteins involved in methylation-driven chromatin regulation. Some outlier terms (metabolism, catabolic processes) appear less connected and may reflect annotation noise, but the dominant pattern supports a methylation/chromatin theme.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031167","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006541","count":2},{"id":"GO:0000183","count":1}]},{"hash":"2148159826159169111","title":"P450-driven lipid and hormone metabolism","description":"This cluster shows enrichment for cytochrome P450\u2013related lipid and hormone pathways (omega-hydroxylase and epoxygenase activities; prostaglandin and calcitriol biosynthesis; triglyceride metabolism) and related reproductive/hormonal processes, suggesting a cohesive theme of lipid hormone metabolism and reproductive signaling.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1900087","count":3},{"id":"GO:0060736","count":2},{"id":"GO:0033072","count":2},{"id":"GO:0036378","count":2},{"id":"GO:0097267","count":2}]},{"hash":"815256346103367460","title":"Unknown","description":"The GO terms are highly heterogeneous (fertilization, oogenesis, neuromuscular control, astrocyte migration, lipid and carbohydrate metabolism, and transcription regulation), with no clear shared function tying the proteins together. There are no edges, suggesting they do not form a coherent functional module. ","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":2},{"id":"GO:0019953","count":1},{"id":"GO:0019915","count":1},{"id":"GO:0050885","count":1},{"id":"GO:0050884","count":1}]},{"hash":"2017669036369276961","title":"Viral DNA integration and proviral latency","description":"This cluster is dominated by GO terms about viral entry into host cells and nucleus, DNA integration and proviral latency, and associated DNA recombination processes, suggesting functions tied to retroviral/viral genome integration and latency maintenance.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0046718","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0006310","count":3}]},{"hash":"462927827291489136","title":"Transposons and Proviral DNA Integration","description":"The cluster shows strong representation of DNA transposition, DNA integration, and retrotransposition, including proviral latency and viral entry into host cells, pointing to a common function related to mobile genetic elements and genome integration; peripheral terms about histone acetylation and cuticle development are less informative for this cluster.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0006313","count":3},{"id":"GO:0015074","count":3}]},{"hash":"1471320339798516861","title":"Viral DNA Integration and Proviral Latency","description":"The top GO terms cluster around viral entry, nuclear penetration, DNA replication and integration, establishment of proviral latency, and reverse transcription\u2013related DNA synthesis, all hallmark features of retroviral life cycles and provirus maintenance. Additional terms about DNA recombination and transposition support a broader theme of mobile genetic element activity and viral manipulation of the host, with some host defense interactions (siRNA processing). This combination points to a cohesive theme of viral genome integration and latent provirus maintenance.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046718","count":6},{"id":"GO:0075732","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0075713","count":6},{"id":"GO:0006310","count":6}]},{"hash":"1131890084067493208","title":"Membrane Transporters (diverse substrates)","description":"The cluster\u2019s top GO terms are dominated by transmembrane transport activities (nitrite/nitrate transport, sodium-dependent/independent transport, vitamin transport, and other substrate transport terms) with an additional vesicular transport reference (neurotransmitter loading). This pattern strongly suggests a group of membrane transporter proteins capable of moving a variety of substrates across membranes, rather than a single, specific metabolic pathway. While a few terms touch on metabolism or older annotations, the unifying theme is transport function across membranes.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0015707","count":1},{"id":"GO:0042128","count":1},{"id":"GO:0043252","count":1},{"id":"GO:0006004","count":1},{"id":"GO:0035461","count":1}]},{"hash":"1496841263471389695","title":"Glucocorticoid/stress response and redox regulation","description":"The Top Terms point to stress and hormone responses (response to ethanol, glucocorticoid stimulus) combined with regulation of inflammatory signaling (negative regulation of TNF signaling and MAPK/JNK activity) and redox/antioxidant processes (glutathione metabolism, oxidant detoxification). This suggests a coherent theme of stress hormone\u2013mediated regulation of inflammation and oxidative stress, hence the chosen name.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045471","count":2},{"id":"GO:0071638","count":1},{"id":"GO:2000469","count":1},{"id":"GO:0006749","count":1},{"id":"GO:0043508","count":1}]},{"hash":"186976805179145121","title":"Neuronal signaling and migration","description":"Based on the GO terms, the cluster centers on neural activity and development: excitatory postsynaptic potential and its regulation point to synaptic signaling, while tangential migration from the subventricular zone to the olfactory bulb indicates neural development. Temperature-related terms and ubiquitination appear more as general regulatory processes and are less defining for the cluster. Therefore, the label captures the core neural theme with some incidental terms.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0090394","count":1},{"id":"GO:0022028","count":1},{"id":"GO:0009409","count":1},{"id":"GO:2000338","count":1},{"id":"GO:0060079","count":1}]},{"hash":"1022856477333138997","title":"Symbiont-driven host gene expression suppression","description":"The top GO terms cluster around host-symbiont interactions, including symbiont-mediated degradation of host mRNA, suppression of host gene expression, and perturbation of host defenses, suggesting a function focused on how symbionts modulate host transcriptional and immune responses. A few terms (cytokine production, development) are peripheral, but the dominant theme points to host gene expression manipulation by symbionts.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071291","count":1},{"id":"GO:0090305","count":1},{"id":"GO:0039595","count":1},{"id":"GO:0039657","count":1},{"id":"GO:0030682","count":1}]},{"hash":"825084594052109916","title":"Unknown","description":"The top terms span neural signaling, immune regulation, development, autophagy, and protein ubiquitination, with no single coherent function binding them all; this cluster appears to contain diverse regulatory proteins rather than a unified pathway.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090394","count":1},{"id":"GO:0032715","count":1},{"id":"GO:0022028","count":1},{"id":"GO:0032474","count":1},{"id":"GO:0006963","count":1}]},{"hash":"1580337557076304895","title":"Retroviral Integration and Latency","description":"The top GO terms point to retroviral processes: proviral latency establishment, DNA integration, viral entry into host cells, viral penetration into the host nucleus, and reverse transcription (RNA-templated DNA synthesis). While other terms relate to general DNA processing, the clustering clearly fits a retroviral life cycle focus, emphasizing genome integration and latency in host cells.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0046718","count":1},{"id":"GO:0090502","count":1}]},{"hash":"326152525114290763","title":"Unknown","description":"The terms span signaling regulation, protein modification/turnover, organelle maintenance, and even development, with no single dominant function linking the proteins. Because the GO terms do not converge on a shared biological theme, I cannot assign a specific, representative name beyond Unknown.","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1901340","count":5},{"id":"GO:1902283","count":5},{"id":"GO:0071816","count":5},{"id":"GO:0016925","count":5},{"id":"GO:0000423","count":5}]},{"hash":"2166750028279704977","title":"Dopaminergic synaptic signaling and development","description":"The dominant terms describe neuronal communication at the synapse (excitatory postsynaptic potential and postsynaptic calcium regulation) and brain development in the substantia nigra, implying dopaminergic synaptic function. The inclusion of a morphine response supports opioid-modulated neuronal signaling, which aligns with dopaminergic pathways. Some terms (EMT, lymphangiogenesis, miRNA processing) appear peripheral to this core theme, but do not negate the main neuronal-development signal.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0061587","count":4},{"id":"GO:0043278","count":4},{"id":"GO:0006986","count":4},{"id":"GO:0099566","count":4}]},{"hash":"2270707049148386373","title":"Ubiquitin-dependent proteolysis and protein modification","description":"The top GO terms are dominated by ubiquitin-related processes: ubiquitin-dependent protein catabolic process, ubiquitin-dependent ERAD, protein ubiquitination, and ISG15-protein conjugation, as well as SUMOylation. These indicate a core theme of protein tagging and degradation. A few terms (amygdala development, cytoplasm-to-vacuole targeting, negative regulation of transcription, and MyD88/TLR signaling) are less central and may reflect broader functional associations or annotation noise in this small cluster. Overall, the cluster most strongly reflects ubiquitin-mediated protein modification and turnover.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0044805","count":1},{"id":"GO:0016925","count":1},{"id":"GO:0021764","count":1}]},{"hash":"1936683065049054553","title":"Multitissue Development and Neural Signaling","description":"A short paragraph explaining: The top GO terms include thymus development, heart development, placenta development, multicellular organism development, and angiogenesis\u2014indicating broad developmental roles across tissues\u2014together with neural-related terms such as long-term synaptic potentiation, excitatory postsynaptic potential, and visual perception. The co-occurrence suggests proteins that participate in widespread developmental processes and neural signaling, rather than a single pathway, so this combined label captures the cluster's theme.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048538","count":4},{"id":"GO:0060291","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0001890","count":3},{"id":"GO:0071276","count":3}]},{"hash":"853784615272610903","title":"DNA replication and heterochromatin maintenance","description":"The top GO terms cluster around chromatin state regulation and replication, including heterochromatin formation (silent mating-type cassette and general heterochromatin), DNA replication initiation and elongation, and replication-associated repair. This suggests the proteins share a theme of chromatin-based genome maintenance during replication/ meiosis, with a few seemingly unrelated terms likely due to annotation noise.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0030466","count":5},{"id":"GO:0010082","count":4},{"id":"GO:0030494","count":4},{"id":"GO:0000727","count":4},{"id":"GO:0006268","count":4}]},{"hash":"2291370896269269203","title":"Mitotic spindle assembly and chromosome alignment","description":"The dominant GO terms center on mitosis\u2014mitotic spindle assembly, centrosome separation, and chromosome alignment\u2014suggesting the proteins mainly participate in mitotic machinery and cell division. Some scattered terms (skin development, aging, inflammatory signaling) appear as noise, but they do not override the core mitotic theme.","confidence":"High","size":5,"edges":6,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0007568","count":3}]},{"hash":"715033986193027522","title":"Neural development and vesicle trafficking","description":"The cluster centers on neural development signals (neural tube patterning, photoreceptor development, GABAergic transmission) but also includes intracellular trafficking processes (Golgi organization, COPII vesicle budding, nuclear envelope organization), suggesting a tied theme between neuronal development and vesicle trafficking pathways.","confidence":"Medium","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051932","count":3},{"id":"GO:0007030","count":3},{"id":"GO:0021532","count":3},{"id":"GO:0042461","count":3},{"id":"GO:0060753","count":3}]},{"hash":"1869584868549607577","title":"Unknown","description":"There are 5 proteins with several interactions, but no GO terms are provided to reveal a common function, so a reliable theme cannot be inferred from the data available.","confidence":"","size":5,"edges":6,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[]},{"hash":"1306147311885195526","title":"Unknown","description":"The GO terms are diverse, including ribosome biogenesis, neural growth and regeneration, various signaling pathways, immune-related processes, and protein localization, with no evident shared function and no edges linking the proteins. This lack of a unifying theme makes a confident, specific label unlikely. Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":1},{"id":"GO:0070445","count":1},{"id":"GO:0042512","count":1},{"id":"GO:0048679","count":1},{"id":"GO:0035791","count":1}]},{"hash":"157095041210069403","title":"Unknown","description":"The top GO terms show a highly diverse set of, in some cases, unrelated processes (RNA processing and nonsense-mediated decay; APC-dependent protein catabolism and mitotic transition; unfolded protein response; morphine response; fat pad development; snoRNP assembly; histone methylation), with no clear common function tying the proteins together. There are 0 edges, suggesting no shared interactions or functional linkage among the members. Given this dispersion, there isn\u2019t a coherent cluster theme to label beyond Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000184","count":2},{"id":"GO:0031145","count":1},{"id":"GO:1901215","count":1},{"id":"GO:0035955","count":1},{"id":"GO:0043278","count":1}]},{"hash":"2083039867770789269","title":"SRP-dependent translation and membrane targeting","description":"The top GO terms are dominated by SRP-dependent cotranslational protein targeting to membrane and negative regulation of translational elongation, pointing to a cluster centered on coordinating translation with co-translational targeting to membranes. The nucleotide metabolism terms are more general and less defining of the cluster\u2019s core function, so the primary theme is SRP-mediated translation and membrane targeting.","confidence":"High","size":5,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045900","count":1},{"id":"GO:0006614","count":1},{"id":"GO:0006616","count":1},{"id":"GO:0046940","count":1},{"id":"GO:0044209","count":1}]},{"hash":"827572276751152451","title":"mRNA Splicing and Polyadenylation Regulation","description":"Most terms cluster around spliceosome-mediated mRNA splicing (cis and alternative) and regulation of polyadenylation/poly(A) tail dynamics, with supporting signals for mRNA stabilization. This points to a functional unit centered on RNA processing and post-transcriptional control rather than coding functions themselves.","confidence":"High","size":5,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":1},{"id":"GO:1900363","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0060211","count":1},{"id":"GO:0075522","count":1}]},{"hash":"275160133444891848","title":"Mitochondrial Electron Transport and ATP Synthesis","description":"The top GO terms are centered on proton transmembrane transport, plasma membrane ATP synthesis coupled electron transport, and mitochondrial respiratory chain complex IV assembly, all pointing to oxidative phosphorylation and energy production in mitochondria. The other terms appear less connected (immune signaling, development), likely incidental annotations, but the dominant theme is mitochondrial energy metabolism.","confidence":"High","size":5,"edges":7,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1902600","count":2},{"id":"GO:0042774","count":2},{"id":"GO:0033617","count":2},{"id":"GO:0030682","count":1},{"id":"GO:0090394","count":1}]},{"hash":"1821588725112516191","title":"Unknown","description":"The terms span calcium transport, neuronal signaling, cell adhesion, bone remodeling, and general signaling; there is no single dominant function tying all five proteins together, and the network shows no interactions (edges) to support a coherent biological niche. So I cannot provide a specific, representative label.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019634","count":1},{"id":"GO:0016310","count":1},{"id":"GO:2001205","count":1},{"id":"GO:0045186","count":1},{"id":"GO:0070588","count":1}]},{"hash":"613052495541138523","title":"Neuronal signaling and dendrite morphogenesis","description":"The GO terms are dominated by neural development and signaling: dendrite morphogenesis, hippocampus development, and positive regulation of JNK, ERK cascades, and Wnt signaling, all of which are key players in neuronal differentiation and dendritic growth. This suggests a cohesive cluster centered on neuronal signal transduction and morphology, with some peripheral terms (like T cell signaling or mitotic cell cycle) that are less representative but do not override the main neural-development theme.","confidence":"Medium","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033138","count":5},{"id":"GO:0048813","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0043552","count":5},{"id":"GO:0046330","count":5}]},{"hash":"959909684441598072","title":"Unknown","description":"The top GO terms cover a mix of apoptosis, epidermis development, cell division regulation, fibroblast proliferation, transcription and mRNA stabilization, endoreduplication, and lymphangiogenesis, with no single unifying function. This lack of a cohesive theme makes a concise, representative label infeasible. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072332","count":1},{"id":"GO:0008544","count":1},{"id":"GO:0032466","count":1},{"id":"GO:0048146","count":1},{"id":"GO:0071930","count":1}]},{"hash":"339877339445189642","title":"Translation and Virus-Host Interaction","description":"This cluster centers on translation and host-pathogen interactions: translation terms are prominent, with virion-related processes (virion assembly, viral entry/penetration, proviral latency) and symbiont entry into host, plus translation-stress responses to antibiotics and cycloheximide and related protein modification steps. Together they suggest a theme of translation machinery linked to virus/symbiont infection and integration.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0046677","count":1},{"id":"GO:0046898","count":1},{"id":"GO:0031365","count":1},{"id":"GO:0043686","count":1}]},{"hash":"456401784890404418","title":"Prostaglandin synthesis and TNF signaling regulation","description":"The GO terms show a clear focus on prostaglandin biosynthesis and the cyclooxygenase pathway, along with negative regulation of TNF signaling and TNF production, indicating modulation of inflammatory pathways via COX/prostaglandin activity. Additional terms related to estradiol response and cellular oxidant detoxification support a broader hormonal/redox context for inflammation, while the few ribosome/rRNA maturation terms appear incidental. Overall, the cluster seems best characterized by prostaglandin synthesis and TNF signaling regulation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":2},{"id":"GO:0010804","count":2},{"id":"GO:0032355","count":2},{"id":"GO:0001516","count":2},{"id":"GO:0071672","count":2}]},{"hash":"1970556016265813568","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0051083","count":1},{"id":"GO:0006620","count":1},{"id":"GO:0002534","count":1},{"id":"GO:0000348","count":1}]},{"hash":"1633986058047950124","title":"Unknown","description":"There are no GO terms to define a shared function, and with only five proteins and modest edges, a clear common theme cannot be established.","confidence":"","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[]},{"hash":"967926121951534626","title":"Protein Ubiquitination","description":"The top GO terms are dominated by ubiquitin-related processes\u2014autoubiquitination, K63-linked ubiquitination, and polyubiquitination (plus ubiquitin-dependent ERAD). Immune-related terms (T follicular helper cell differentiation, lymph node development) appear but are secondary. This suggests the cluster centers on ubiquitin conjugation/signaling rather than a single immune function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":3},{"id":"GO:0070534","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0061470","count":2},{"id":"GO:0035372","count":2}]},{"hash":"1868401971278158926","title":"RNA processing factors","description":"The top GO terms are dominated by mRNA splicing via spliceosome (GO:0000398) and mRNA branch site recognition (GO:0000348), with at least one term for rRNA maturation, suggesting a core function in RNA processing and splicing. Other terms like cytokine production or skin development appear less related and may reflect broader or non-specific annotations, but the RNA processing signal is the strongest among the listed terms.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0002534","count":1},{"id":"GO:0000348","count":1},{"id":"GO:0010255","count":1},{"id":"GO:0048568","count":1}]},{"hash":"925105421591369636","title":"Exosome Biogenesis and Endosomal Trafficking","description":"Top GO terms show a cohesive pattern of vesicle trafficking in the late secretory pathway\u2014exosomal secretion, endosome-to-lysosome transport, multivesicular body assembly, and Golgi vesicle budding/organization\u2014indicating a cluster centered on exosome formation and endosomal-Golgi trafficking. Some peripheral terms (GABAergic synaptic transmission, viral RNA replication, sensory perception) are less representative but may relate indirectly to vesicle cycling or be noise.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990182","count":3},{"id":"GO:0008333","count":3},{"id":"GO:0036258","count":3},{"id":"GO:0036010","count":2},{"id":"GO:0048194","count":2}]},{"hash":"776167977310649887","title":"Transmembrane ion and metabolite transport","description":"The top GO terms are dominated by diverse transmembrane transport activities across ions (sodium, potassium, monoatomic anions) and metabolites (malate, succinate, citrate, phosphate), suggesting a cluster of membrane transport proteins with varied substrates. An outlier term for prostate gland growth is likely unrelated to the core function. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015743","count":1},{"id":"GO:0015700","count":1},{"id":"GO:0015744","count":1},{"id":"GO:0098656","count":1},{"id":"GO:0006814","count":1}]},{"hash":"161073962887341142","title":"mRNA processing and splicing regulation","description":"This cluster includes GO terms for spliceosome-mediated splicing, regulation of alternative splicing, and mRNA polyadenylation, plus other RNA-processing activities such as tRNA import; a few heat-stress related terms appear but the strongest signal centers on RNA processing and splicing regulation.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009246","count":2},{"id":"GO:0045454","count":1},{"id":"GO:0035719","count":1},{"id":"GO:0051259","count":1},{"id":"GO:0045292","count":1}]},{"hash":"664554827376140314","title":"Xenobiotic and nutrient membrane transporters","description":"GO terms are dominated by transmembrane transport activities, especially xenobiotic transport and nutrient (carbohydrate, amino acid, vitamin, potassium) transport, suggesting these proteins function primarily as membrane transporters for xenobiotics and nutrients. An outlier GO term related to antigen processing via MHC I is likely incidental annotation rather than indicative of a shared function. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042908","count":4},{"id":"GO:0035461","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0046618","count":2}]},{"hash":"1657092303120500726","title":"Broad-Substrate Membrane Transporters","description":"The top GO terms show transport across membranes for diverse substrates (xenobiotics, cholesterol, carbohydrates, amino acids, cysteine, taurine, and cGMP), suggesting these proteins act as membrane transporters with broad specificity. The immune-related term (MHC class I antigen processing) seems incidental. Overall, the cluster best fits broad-substrate membrane transporters.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046618","count":2},{"id":"GO:0033344","count":2},{"id":"GO:0070731","count":2},{"id":"GO:0008643","count":2},{"id":"GO:0015803","count":2}]},{"hash":"78165212397977332","title":"Unknown","description":"Top terms span diverse, largely unrelated biosynthetic and signaling processes (heme/biotin/protoporphyrinogen IX biosynthesis, sphingomyelin biosynthesis, fatty acid transport) along with regulatory pathways (Notch signaling, insulin response, fruit ripening). There isn't a single coherent theme connecting these functions, so I label this cluster Unknown.","confidence":"","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019878","count":3},{"id":"GO:0006686","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0007219","count":2},{"id":"GO:0015908","count":2}]},{"hash":"1647325670944579322","title":"Splicing Regulation and mRNA Processing","description":"Most GO terms cluster around regulation of mRNA splicing via the spliceosome, including alternative/spliceosome-mediated splicing and regulation of polyadenylation, indicating a shared theme of post-transcriptional RNA processing control. A lone term about proteasome assembly is present but does not define the cluster, so the dominant signal is splicing/processing regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043248","count":1},{"id":"GO:0010950","count":1},{"id":"GO:0045292","count":1},{"id":"GO:1900363","count":1},{"id":"GO:0000381","count":1}]},{"hash":"1742757000765737424","title":"P450-driven lipid and hormone metabolism","description":"The GO terms cluster around cytochrome P450\u2013mediated lipid processing and hormone biosynthesis: omega-hydroxylase and epoxygenase P450 pathways, prostaglandin biosynthesis, triglyceride metabolism, and calcitriol synthesis. Some terms touch on development and sex differentiation, which can be linked to endocrine signaling. Overall, the common theme is lipid/hormone metabolism driven by P450 enzymes.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060736","count":5},{"id":"GO:0033072","count":5},{"id":"GO:0036378","count":5},{"id":"GO:0097267","count":5},{"id":"GO:0006641","count":5}]},{"hash":"833143123588587805","title":"Unknown","description":"The terms span immune signaling (cytokine production), RNA processing and ribosome biogenesis, peroxisome targeting, and various developmental pathways, with no clear shared function linking the proteins. Because of this lack of a cohesive theme, a specific, representative label cannot be confidently assigned. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002534","count":2},{"id":"GO:0000348","count":2},{"id":"GO:0010255","count":2},{"id":"GO:0048568","count":2},{"id":"GO:0043588","count":2}]},{"hash":"1692227219991762872","title":"Immune and Developmental Processes","description":"The top GO terms span immune-related responses (cellular response to lipopolysaccharide, type IV hypersensitivity, apoptosis execution) and developmental/differentiation processes (multicellular organism development, bronchus morphogenesis, fat cell differentiation, regulation of axon regeneration). This mix suggests the proteins participate in broad regulatory networks coordinating immune signaling with tissue development and remodeling, rather than a single cohesive pathway.","confidence":"Medium","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042220","count":5},{"id":"GO:0007257","count":4},{"id":"GO:1903655","count":4},{"id":"GO:0097194","count":4},{"id":"GO:0071222","count":4}]},{"hash":"1544054440719103165","title":"Unknown","description":"Top GO terms include developmental processes (heart and cerebellum development), neuronal signaling (excitatory postsynaptic potential), gene regulation, and various membrane transports, plus sperm capacitation. These terms do not converge on a single clear function, so a coherent label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048240","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0006349","count":2},{"id":"GO:0021549","count":2},{"id":"GO:0060079","count":2}]},{"hash":"1200250057519006302","title":"Lipid Biosynthesis and Metabolism","description":"The dominant GO terms point to lipid- and fat-related biosynthetic and metabolic processes (fatty acid elongation, mycolic acid biosynthesis, polyhydroxybutyrate biosynthesis, and retinoid-related lipid metabolism). While there are a few outliers (transcription regulation, an obsolete oxidation-reduction term), the overall theme across the cluster centers on lipid and related metabolite biosynthesis and storage. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0042619","count":3},{"id":"GO:0042572","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0006729","count":2}]},{"hash":"409532801043245563","title":"Plant RNA and protein methylation with chromatin modification","description":"The top GO terms cluster around methylation-related processes (peptidyl-lysine dimethylation/trimethylation, N-terminal methylation, tRNA wobble modification) and RNA processing (mRNA capping), along with chromatin regulation (rDNA heterochromatin formation). While some plant-specific processes like nodulation and chlorophyll biosynthesis appear, the cohesive signal is methylation-based modification of RNAs and proteins and associated chromatin regulation in plants.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":2},{"id":"GO:0018027","count":2},{"id":"GO:0009877","count":2},{"id":"GO:0000183","count":2},{"id":"GO:0036068","count":2}]},{"hash":"1720583454493613712","title":"COPI-mediated Golgi-ER trafficking and Wnt secretion","description":"The top GO terms point to COPI/coated vesicle dynamics and ER-to-Golgi transport, plus Golgi ribbon formation and regulation of Wnt protein secretion, indicating a cohesive vesicle trafficking and secretion module centered on the Golgi-ER axis. Some developmental terms appear, but the core signal is secretory pathway function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090161","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0061357","count":2},{"id":"GO:0070863","count":2},{"id":"GO:0001893","count":2}]},{"hash":"2227372562060885758","title":"Ubiquitin-Proteasome Regulation in Insulin Signaling","description":"The top GO terms show clear involvement in ubiquitination and proteasomal degradation, suggesting a proteostasis-focused cluster. The insulin-related terms (positive regulation of glucose import in response to insulin stimulus; glucose homeostasis; negative regulation of insulin secretion) imply a link to insulin signaling and metabolic regulation. Other terms like cellular response to mechanical stimulus or tyrosine autophosphorylation may be peripheral or context-dependent. Overall, the proteins appear to converge on ubiquitin-mediated control of metabolic signaling, justifying this label with moderate confidence.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0046676","count":2},{"id":"GO:0032436","count":2},{"id":"GO:0071260","count":2}]},{"hash":"2201467399517764608","title":"Unknown","description":"The GO terms listed are highly diverse with no single shared biological process or molecular function (inflammatory cytokine production; mRNA branch site recognition; glucose signaling; embryonic and skin development; plant polarity; peroxisome targeting; rRNA maturation; viral translation mechanism; growth hormone response), so there isn\u2019t a cohesive theme to name a specific function for this cluster.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002534","count":1},{"id":"GO:0000348","count":1},{"id":"GO:0010255","count":1},{"id":"GO:0048568","count":1},{"id":"GO:0043588","count":1}]},{"hash":"486938724194571304","title":"Carbohydrate Metabolism and Storage","description":"This cluster is dominated by GO terms for carbohydrate synthesis and storage, with glycogen, starch, and sucrose biosynthesis/metabolism all prominently represented, suggesting the proteins contribute to energy storage and carbohydrate metabolism. Other terms (apoptotic process, redox homeostasis, base-excision repair) appear at lower representation and are likely ancillary. ","confidence":"High","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0046856","count":2},{"id":"GO:0005985","count":2},{"id":"GO:0005978","count":2},{"id":"GO:0019252","count":2}]},{"hash":"1799452139768382615","title":"Embryogenesis and Organ Morphogenesis","description":"The top GO terms converge on embryonic development and the shaping of tissues and organs (endocrine system development, placenta and pancreas development, cartilage morphogenesis, and cardiac cushion EMT/left-right patterning), indicating a cohesive theme of morphogenesis during development. A couple of more general cellular terms (mRNA splicing, histone modification) are secondary contributors. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035270","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0003323","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0003198","count":4}]},{"hash":"1286676692874738764","title":"Embryonic neural and cardiac development","description":"The top GO terms cluster around developmental and morphogenetic processes in the embryo, especially neural migration and axon guidance, heart development, organ induction, and cranial skeletal morphogenesis, with angiogenesis also underlining vascularization; a cohesive theme of early tissue formation emerges, though a couple terms (adaptive immune response, symbiont entry) appear as broader annotations.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0001764","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0001759","count":3},{"id":"GO:0048701","count":3}]},{"hash":"2058182362284929274","title":"Proviral integration and DNA transposition","description":"These proteins collectively show terms related to movement and integration of genetic material: DNA transposition (GO:0006313), DNA integration (GO:0015074), and establishment of proviral latency (GO:0075713). The presence of symbiont entry into host cell (GO:0046718) likewise points toward host\u2013genome interactions associated with viral or transposable elements. Additional terms refer to cell cycle and chromosome segregation, which can accompany genome replication, but do not define a single functional pathway. Together, they suggest a cluster centered on genome mobility and integration events, especially proviral DNA integration and transposition, rather than a focused metabolic or signaling process.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0015074","count":1}]},{"hash":"554033732729170644","title":"Retroviral DNA integration and latency","description":"Terms point to retroviral entry, nuclear penetration, proviral latency, and DNA integration, plus RNA-templated DNA synthesis and recombination/transposition. This strongly suggests involvement in the retroviral life cycle, especially proviral integration and latency. Therefore label: Retroviral DNA integration and latency","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0046718","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":3}]},{"hash":"2269819808963190892","title":"Dimethylation-based protein modification and cofactor biosynthesis","description":"The top GO terms show two explicit dimethylation events on proteins (N-terminal serine and peptidyl-lysine), pointing to protein methylation as a shared feature. Additionally, several terms relate to biosynthesis of cofactors (ubiquinone, phylloquinone, biotin), suggesting a broader theme of biosynthetic processes. Some unrelated terms exist, but the combination of protein methylation and cofactor biosynthesis provides a plausible cohesive label for this cluster.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":2},{"id":"GO:0006744","count":2},{"id":"GO:0035572","count":2},{"id":"GO:0006972","count":2},{"id":"GO:0042372","count":2}]},{"hash":"359057932401281615","title":"Organ and tissue development","description":"The strongest signals are kidney development, embryonic organ development, and skin development, suggesting a core theme of organogenesis and tissue differentiation. Peripheral terms (cytokine production, glucose signaling) and a few obsolete or plant-specific terms reduce coherence, so the label reflects the dominant developmental theme with moderate confidence.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0002534","count":1}]},{"hash":"761859932546376241","title":"mRNA processing and translation initiation","description":"The proteins are enriched for GO terms related to splicing via the spliceosome, mRNA processing such as polyadenylation regulation, and various modes of translation initiation (including reinitiation and IRES-dependent initiation), indicating roles in post-transcriptional RNA processing and control of translation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0045292","count":3},{"id":"GO:1900363","count":3},{"id":"GO:0000381","count":3}]},{"hash":"524010509181436374","title":"Cardiac signaling and heart function regulation","description":"The cluster is dominated by GO terms tied to cardiovascular regulation: positive regulation of cardiac muscle contraction, regulation of systemic arterial blood pressure, regulation of cardiac conduction, and angiotensin-related processes (maturation and angiogenic signaling). There are also signaling-related terms (positive regulation of protein tyrosine kinase activity, peptidyl-nitrosylation/autophosphorylation) that align with pathways modulating heart function. A few terms (ecdysis/cuticle, response to symbiotic bacterium) appear as outliers, but the core theme centers on cardiovascular signaling and heart physiology.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042395","count":3},{"id":"GO:0061098","count":3},{"id":"GO:0003084","count":3},{"id":"GO:0060452","count":3},{"id":"GO:2000170","count":3}]},{"hash":"1432482786618358060","title":"Unknown","description":"The terms include broad developmental processes across several tissues (cartilage/chondrocyte development, glomerular structures, CNS development, innervation) and regulatory signaling, but they also include unrelated terms like lipoteichoic acid biosynthesis and choline biosynthesis, with no clear shared pathway or function tying the proteins together. The lack of a cohesive theme and no network connectivity suggest no confident single-label function. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002063","count":4},{"id":"GO:0032836","count":4},{"id":"GO:0035860","count":4},{"id":"GO:0070395","count":4},{"id":"GO:0040037","count":4}]},{"hash":"2209648481012145733","title":"Mitotic kinetochore\u2013spindle assembly","description":"The top GO terms are dominated by kinetochore\u2013spindle functions: attachment of spindle microtubules to the kinetochore, kinetochore assembly, spindle organization, and metaphase chromosome alignment, all pointing to a role in mitotic chromosome segregation. A couple of outlier terms exist but do not override the main theme. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051455","count":1},{"id":"GO:0090268","count":1},{"id":"GO:1903394","count":1},{"id":"GO:0007052","count":1},{"id":"GO:0000132","count":1}]},{"hash":"2115994797406696924","title":"Lipid Biosynthesis and Transport","description":"This cluster\u2019s terms cluster around lipid metabolism and transport, including globoside biosynthesis, mannosyl-inositol phosphorylceramide biosynthesis, cholesterol efflux, and carotenoid transport, suggesting a common theme of lipid biosynthesis/transport. Some other terms (cell surface receptor signaling, endothelial proliferation) may reflect membrane-associated signaling contexts or annotation noise, but the dominant signal points to lipid-related processes.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0036210","count":1},{"id":"GO:0001576","count":1},{"id":"GO:0051999","count":1},{"id":"GO:0007166","count":1},{"id":"GO:0001935","count":1}]},{"hash":"1115002873369828891","title":"ECM-Integrin Mediated Cell Migration","description":"The terms cluster around integrin signaling, collagen/fibronectin interaction, and migration of immune cells (thymocytes, T cells), suggesting a shared role in adhesion-driven cell movement and ECM remodeling. Inflammation-related terms also appear but the dominant theme is ECM-dependent migration and adhesion.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002675","count":1},{"id":"GO:2001113","count":1},{"id":"GO:0032331","count":1},{"id":"GO:2000415","count":1},{"id":"GO:0051968","count":1}]},{"hash":"662268557955807704","title":"Unknown","description":"These terms span inflammation (leukotriene production), nervous system processes (innervation, regulation of nerve impulse), renal/angiotensin regulation, lipid metabolism, and extracellular matrix (collagen organization); there is no single cohesive function uniting these terms, so a specific, descriptive cluster label cannot be confidently assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":1},{"id":"GO:0035491","count":1},{"id":"GO:0051969","count":1},{"id":"GO:0002019","count":1},{"id":"GO:0051055","count":1}]},{"hash":"2241382564672093307","title":"Ubiquitin-Proteasome\u2013Mediated Proteolysis","description":"The top GO terms are clearly centered on ubiquitin-dependent protein catabolic processes and SCF-dependent proteasomal degradation, indicating that the core function of this cluster is targeted protein degradation and proteostasis. While other terms touch on development, circadian regulation, and neural processes, these appear ancillary to the dominant ubiquitin-proteasome\u2013driven catabolic activity.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":3},{"id":"GO:0008285","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0021678","count":2},{"id":"GO:0070544","count":2}]},{"hash":"126084304238795919","title":"Unknown","description":"The listed GO terms span nervous system activity (proprioception, excitatory postsynaptic potential), development (cartilage morphogenesis, vulval cell fate), metabolism (glucocorticoid metabolic process), respiration, DNA replication initiation, and behavior, with little overlap and each term appearing once. There is no clear shared function or pathway tying the proteins together, so a coherent label cannot be inferred.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019230","count":1},{"id":"GO:0072325","count":1},{"id":"GO:0008211","count":1},{"id":"GO:0007585","count":1},{"id":"GO:0032298","count":1}]},{"hash":"277798874920173442","title":"Unknown","description":"The GO terms span many unrelated processes (ERAD, aging, cadherin-mediated adhesion, cholesterol regulation, mitochondrial fusion, podocyte development, TLR3 signaling, excretion, dopaminergic synaptic transmission, and ECM disassembly), with no clear unifying function across all four proteins. This makes it difficult to assign a cohesive, specific label. ","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0001302","count":1},{"id":"GO:2000049","count":1},{"id":"GO:0045541","count":1},{"id":"GO:1990046","count":1}]},{"hash":"514539840879810192","title":"Metal Ion Transport and Homeostasis","description":"The GO terms cluster around metal ion handling\u2014iron, zinc, cobalt\u2014covering transmembrane transport, intracellular homeostasis, and cadmium detoxification, which points to a shared role in maintaining metal balance and metal-responsive regulation, with a possible link to metalloprotease activity.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035551","count":2},{"id":"GO:0034724","count":2},{"id":"GO:0034396","count":2},{"id":"GO:0030574","count":2},{"id":"GO:0071584","count":1}]},{"hash":"1000423169573344870","title":"Organelle Stress Response and Trafficking","description":"The top GO terms point to oxidative stress response, endosomal microautophagy, peroxisomal protein import, ER polarization, and stress-related regulation of respiration, suggesting a cluster centered on how cells manage organelle function under stress and coordinate trafficking/maintenance. Despite some obsolete terms, the shared theme is organelle-focused stress response and homeostasis.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030420","count":4},{"id":"GO:0061738","count":4},{"id":"GO:0034599","count":4},{"id":"GO:0001319","count":4},{"id":"GO:0000733","count":4}]},{"hash":"836696382028825072","title":"Proteostasis and stress response","description":"Based on the GO terms, the cluster centers on protein maintenance and protection under stress (protein stabilization; negative regulation of amyloid fibril formation) and includes multiple stress-response signals (heat, high light, hydrogen peroxide, UV-A). Although some terms touch on lens morphogenesis and muscle contraction, the common thread is proteostasis under environmental stress, so this label captures the core theme.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050821","count":1},{"id":"GO:1905907","count":1},{"id":"GO:0009644","count":1},{"id":"GO:0009408","count":1},{"id":"GO:0070309","count":1}]},{"hash":"301109540984253569","title":"Embryonic and Organ Development","description":"The terms center on developmental processes across tissues (embryonic organ development, skin development, spinal cord development, seminiferous tubule development, multicellular organism growth), with a secondary link to cell division (mitotic sister chromatid cohesion). No protein-protein interactions are reported, suggesting the proteins are variably tied to broader developmental processes rather than a single pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0048568","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0072520","count":2},{"id":"GO:0007064","count":2}]},{"hash":"1061609619103765041","title":"Spliceosome-Driven mRNA Processing and Polyadenylation Regulation","description":"The shared GO terms center on spliceosome-mediated mRNA splicing, regulation of alternative splicing, regulation of polyadenylation, and mRNA stabilization, indicating a cohesive cluster of proteins involved in post-transcriptional mRNA maturation and its regulatory steps.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":2},{"id":"GO:1900363","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0060211","count":2},{"id":"GO:0075522","count":2}]},{"hash":"2076198134432581602","title":"RNA Processing and Spliceosome Assembly","description":"The proteins show strong ties to RNA metabolism: mRNA decapping, splicing via the spliceosome, snRNP and spliceosomal complex assembly, mRNA processing, nuclear import, rRNA maturation, and P-body assembly. This suggests a cluster of RNA processing and ribonucleoprotein\u2013assembly factors, possibly including spliceosome components and RNA decay factors. The ABA response term may reflect plant-specific regulation but the dominant theme is RNA processing and maturation.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000290","count":4},{"id":"GO:0070317","count":4},{"id":"GO:0051170","count":4},{"id":"GO:0030490","count":4},{"id":"GO:0033962","count":4}]},{"hash":"927079079166356751","title":"Ribosome biogenesis and translation initiation","description":"The GO terms are strongly centered on ribosome assembly and the start of translation: formation of translation preinitiation complex, maturation of SSU-rRNA, and cytoplasmic translation, with regulation of translational initiation. This suggests a functional cluster tied to ribosome biogenesis and control of protein synthesis, with additional, less central signals of broader gene expression regulation (splicing, ubiquitination) that can accompany translation-related processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0002181","count":1},{"id":"GO:0006446","count":1},{"id":"GO:0006977","count":1}]},{"hash":"1230205224597263475","title":"Unknown","description":"There is no shared GO term signal or interaction among the four proteins (Edges: 0, Triangles: 0, Max Degree: 0) and no top GO terms listed, so there is no coherent functional theme to label. The note about \"20 proteins re-added by ReCIPE\" appears to reflect curation rather than biology. Without common functional annotations, this cluster cannot be confidently assigned a specific function.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"262200914079644735","title":"Symbiont-mediated suppression of host gene expression","description":"The presence of GO terms explicitly describing symbiont-mediated degradation of host mRNA and suppression of host gene expression suggests a functional grouping centered on host gene expression modulation by symbiotic organisms. While other terms in the set (redox homeostasis, tRNA import, and chromosomal/spliceosomal processes) are more general or less connected, the two symbiont-related terms dominate the apparent theme for this cluster.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":1},{"id":"GO:0039595","count":1},{"id":"GO:0039657","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0035719","count":1}]},{"hash":"155248481811111082","title":"Spliceosome-regulated mRNA splicing and processing","description":"The GO terms cluster around splicing and wider mRNA maturation: multiple entries describe spliceosome-mediated splicing (including regulation of alternative splicing and positive regulation of splicing), as well as related processes like mRNA stabilization and poly(A) tail regulation. This suggests a cohesive theme of post-transcriptional control centered on spliceosome-driven mRNA processing, with regulatory ncRNA involvement as part of the regulatory layer. IRES-dependent translation appears peripherally related but not central to the main theme.","confidence":"High","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0045292","count":2},{"id":"GO:1900363","count":2},{"id":"GO:0000381","count":2}]},{"hash":"567491623844882829","title":"Immune cell adhesion and migration regulation","description":"This cluster has several GO terms focused on movement and adhesion of immune cells and related cells, including lymphocyte chemotaxis, thymocyte and keratinocyte migration, and integrin- and fibronectin-mediated adhesion. It also includes regulatory aspects like negative regulation of complement activation and positive regulation of TNF ligand production, suggesting modulation of inflammatory signaling and cell interactions in immune contexts. While some differentiation terms appear, the prevailing theme is regulation of immune cell adhesion and migration and associated inflammatory control.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045636","count":2},{"id":"GO:0033630","count":2},{"id":"GO:0045959","count":2},{"id":"GO:2001113","count":2},{"id":"GO:0032331","count":2}]},{"hash":"1793939128462766769","title":"Unknown","description":"The top GO terms are a heterogeneous mix (cell cycle, heat/cold stress response, transcription regulation, protein ubiquitination, immune-related processes, and pain perception) with no clear, single function uniting the cluster. This lack of a cohesive theme suggests the proteins do not share a common, specific biological role in this cluster.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0061470","count":1},{"id":"GO:0009409","count":1},{"id":"GO:0009408","count":1},{"id":"GO:0016567","count":1}]},{"hash":"1889334648139232172","title":"Neuronal synapse formation and plasticity","description":"Top GO terms indicate a strong emphasis on synapse assembly, dendritic spine development, postsynaptic density regulation, and synaptic plasticity, with supporting roles in receptor-mediated endocytosis and electrical coupling. Some terms (rRNA processing, proton-motive ATP synthesis) are more general housekeeping processes, but they do not negate the central neuronal synapse theme. Therefore, the cluster is best described as involving neuronal synapse formation and plasticity.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006364","count":1},{"id":"GO:0042777","count":1},{"id":"GO:0099132","count":1},{"id":"GO:0007416","count":1},{"id":"GO:0060999","count":1}]},{"hash":"1821580951558469595","title":"Embryonic Morphogenesis and Neural Development","description":"The terms point to embryonic tissue formation and brain-related patterning (ectoderm formation, cerebral cortex regionalization, hypophysis morphogenesis) with concurrent transcriptional regulatory activity, suggesting a cohesive theme of early developmental processes shaping neural and tissue development, despite some kidney- and glial-differentiation related terms.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0048557","count":1},{"id":"GO:0035623","count":1},{"id":"GO:0021913","count":1},{"id":"GO:0045686","count":1}]},{"hash":"13908434993312608","title":"Developmental transcriptional regulation","description":"The shared signature is transcriptional control by RNA polymerase II linked to developmental processes. Top GO terms include regulation of DNA-templated transcription, transcription initiation at RNA Pol II promoters, and snRNA transcription, plus CNS formation, segment specification, antennal and compound eye development. This points to a role in coordinating gene expression during development rather than a metabolic function; the obsolete terms are likely annotation artifacts.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0006367","count":1},{"id":"GO:0042795","count":1},{"id":"GO:1903212","count":1},{"id":"GO:0021556","count":1}]},{"hash":"32737595138046226","title":"Membrane transport and intracellular trafficking","description":"This cluster\u2019s GO terms cluster around membrane-associated processes: multiple transmembrane transports for nutrients (myo-inositol, pantothenate, biotin, glucose) and sodium export, plus regulation of ER to Golgi vesicle transport. Developmental terms (larval cuticle and intestinal epithelial development) and acetylcholine synthesis hint at roles during growth and neural signaling, suggesting these proteins participate in transport and trafficking mechanisms essential in development and host interactions. Confidence in this label is Medium.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":1},{"id":"GO:0015798","count":1},{"id":"GO:0015887","count":1},{"id":"GO:0008292","count":1},{"id":"GO:0071436","count":1}]},{"hash":"23666745245540734","title":"Unknown","description":"The terms span several distinct areas (protein quality control, stress responses, immune signaling, telomere localization, virion assembly, fertilization, and drug response) with no single coherent function tying all four proteins together. This lack of a unifying theme makes it hard to assign a specific, representative label, so Unknown is appropriate.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050821","count":4},{"id":"GO:0002931","count":4},{"id":"GO:0002842","count":4},{"id":"GO:1904851","count":4},{"id":"GO:0019068","count":4}]},{"hash":"1416438950350252551","title":"Unknown","description":"The two GO terms hint at very different themes (selenium ion response vs. symbiont-mediated perturbation of host defenses), and with no edges or shared functional annotation linking the proteins, there is no coherent function that ties all four proteins together. Therefore, a reliable, specific label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071291","count":1},{"id":"GO:0030682","count":1}]},{"hash":"996592360881799390","title":"Ion transport and membrane potential regulation","description":"The top GO terms point to regulation of potassium ion transport and maintenance of membrane potential, including intracellular potassium homeostasis, stabilization of membrane potential, resting potential regulation, and cardiac muscle cell repolarization. Phospholipid translocation also ties to membrane organization, supporting a membrane-centric function. A few terms about saliva secretion, gastric acid regulation, and mechanosensory touch appear peripheral, but the core cluster seems driven by ion transport and membrane potential maintenance, justifying a membrane/ion-centric label.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046541","count":1},{"id":"GO:1903640","count":1},{"id":"GO:0050976","count":1},{"id":"GO:0098914","count":1},{"id":"GO:1901379","count":1}]},{"hash":"2065420277954100654","title":"Unknown","description":"The set of GO terms is highly diverse, spanning neural development and synaptic functions (neural tube patterning, photoreceptor development, GABAergic transmission) as well as broad cellular processes (Golgi organization, nuclear envelope organization, ribosome biogenesis) and immune cell chemotaxis. This lack of a single cohesive biological theme suggests there isn\u2019t a clear shared function for this cluster.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051932","count":2},{"id":"GO:0007030","count":2},{"id":"GO:0021532","count":2},{"id":"GO:0042461","count":2},{"id":"GO:0060753","count":2}]},{"hash":"275281352658640670","title":"Actin Cytoskeleton Remodeling and Muscle Development","description":"The cluster shows strong signals for actin cytoskeleton dynamics (Arp2/3-mediated nucleation, cytokinesis, endocytosis regulation) and muscle-related assembly/development (thin filament assembly, skeletal muscle fiber development), plus calcium response as a signaling context. Some neural/retina terms appear, but the unifying theme centers on actin remodeling driving cell shape, division, and muscle structure.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000281","count":4},{"id":"GO:1904623","count":4},{"id":"GO:0048741","count":4},{"id":"GO:0051592","count":4},{"id":"GO:0001895","count":4}]},{"hash":"1583911897116228909","title":"Drosophila neural and sensory development","description":"Top GO terms cluster around development of the nervous system and sensory organs in Drosophila (CNS formation, compound eye and antennal development, segment specification), with some related muscle development. Some entries are obsolete or unrelated annotations, but the common theme is neural and sensory organ development and function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903212","count":1},{"id":"GO:0021556","count":1},{"id":"GO:0007379","count":1},{"id":"GO:0007469","count":1},{"id":"GO:1902064","count":1}]},{"hash":"985460315060486544","title":"Ion homeostasis and muscle contraction regulation","description":"The cluster's GO terms cluster around ion homeostasis (manganese, sodium, potassium, calcium), maintenance of electrochemical gradients, and regulation of muscle contraction (heart and fast-twitch skeletal). These converge on ion transport and excitation-contraction coupling, with supporting signals such as calcium release and steroid hormone responsiveness, suggesting proteins that regulate ion balance and muscle excitability.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030026","count":3},{"id":"GO:0045822","count":3},{"id":"GO:0071383","count":3},{"id":"GO:0000749","count":3},{"id":"GO:0010248","count":3}]},{"hash":"2050980257917268135","title":"RNA Processing and Ribosome Biogenesis","description":"Clustered GO terms center on nuclear RNA transcription/processing (RNA pol I termination, spliceosomal conformational changes, post-transcriptional gene silencing) and ribosome assembly, with additional hints of chromatin remodeling and histone modification. This suggests a coherent theme of RNA processing and ribosome biogenesis in the nucleus, despite a single neuronal signaling term present. ","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090394","count":2},{"id":"GO:0071035","count":2},{"id":"GO:0006363","count":2},{"id":"GO:0000393","count":2},{"id":"GO:0016584","count":2}]},{"hash":"1598924880725802237","title":"Chromatin silencing and genome organization","description":"The top GO terms are dominated by chromatin-related processes: negative regulation of heterochromatin formation, nucleosome positioning, gene silencing, and sister chromatid cohesion, which all point to chromatin remodeling and genome architecture. Some terms about muscle development and denervation appear context-specific, but the core cluster appears to gather proteins involved in chromatin silencing and genome organization, justifying this label.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0061186","count":4},{"id":"GO:0016584","count":4},{"id":"GO:0045668","count":4},{"id":"GO:0010978","count":4},{"id":"GO:0061587","count":4}]},{"hash":"2277017215759698609","title":"Actin cytoskeleton remodeling in muscle development","description":"The top GO terms center on actin filament dynamics and skeletal muscle formation, including Arp2/3-mediated actin nucleation, thin filament assembly, and skeletal muscle fiber development, with a calcium response signal. While some terms are peripheral (e.g., neural development, other unrelated processes), the core theme is actin remodeling linked to muscle differentiation and function.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000281","count":2},{"id":"GO:1904623","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0051592","count":2},{"id":"GO:0001895","count":2}]},{"hash":"209863471013109146","title":"Symbiont-mediated host defense perturbation","description":"This cluster is defined by GO:0030682, indicating proteins involved in perturbing host defenses via symbiotic interactions. With four proteins and no edges, the shared theme appears to be immune modulation by symbionts.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030682","count":2}]},{"hash":"378609029316019528","title":"Polyamine biosynthesis and transport","description":"The top GO terms are centered on polyamine metabolism: spermidine and putrescine biosynthetic processes and positive regulation of polyamine transmembrane transport, with supporting related terms like arginine catabolic pathways. This suggests the cluster is enriched for proteins involved in polyamine production and transport. Some unrelated terms appear, but the dominant signal points to polyamine metabolism as the core function. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008295","count":2},{"id":"GO:0033387","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0098629","count":2},{"id":"GO:1902269","count":2}]},{"hash":"1139166729466246012","title":"Embryonic organogenesis and neuronal differentiation","description":"The GO terms cluster around differentiation and development across multiple organ systems (neural, cardiovascular, kidney, lung), including timing and lineage-specific differentiation, rather than a single, shared molecular function. This suggests a broad developmental theme rather than a tight, single-pathway function.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0061103","count":4},{"id":"GO:0003062","count":4},{"id":"GO:2000820","count":4},{"id":"GO:0060165","count":4},{"id":"GO:0072277","count":4}]},{"hash":"1415822532861474041","title":"Unknown","description":"The top GO terms span diverse, largely unrelated processes (GTPase regulation, inflammatory cytokine production, RNA processing, glucose signaling, various aspects of development and patterning, peroxisome targeting, rRNA maturation, and growth hormone response), with no clear, single theme that ties the proteins together.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0002534","count":1},{"id":"GO:0000348","count":1},{"id":"GO:0010255","count":1},{"id":"GO:0048568","count":1}]},{"hash":"1152648547610440926","title":"Diverse Membrane Transport","description":"This cluster centers on transport activities across membranes for a wide range of substrates, including xenobiotics, carbohydrates, amino acids, cysteine, taurine, and fatty acids, as well as peptide export. Although one term related to antigen processing appears, the dominant pattern is transporter activity and transmembrane movement, suggesting these proteins act as diverse solute transporters or secretion-related components.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046618","count":2},{"id":"GO:0008643","count":2},{"id":"GO:0015803","count":2},{"id":"GO:0019885","count":2},{"id":"GO:0017004","count":2}]},{"hash":"1524422923388911124","title":"Diverse detoxification and catabolic metabolism","description":"The cluster's GO terms point to broad metabolic breakdown of diverse substrates, with several catabolic processes (e.g., 3-phenylpropionate, 1,2-dichloroethane, triglyceride, glucuronoside, prostaglandin, beta-ketoadipate) and a detoxification term (cellular oxidant detoxification). Although a few terms are biosynthetic, the prevailing pattern is metabolism and clearance of xenobiotics/metabolites, suggesting a general detoxification/catabolic role.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019380","count":2},{"id":"GO:0019260","count":1},{"id":"GO:0019433","count":1},{"id":"GO:0098869","count":1},{"id":"GO:0019391","count":1}]},{"hash":"254210500526243086","title":"GPCR-cAMP-PLC Signaling and Phototransduction","description":"These proteins are linked to multiple GO terms centered on GPCR-mediated signal transduction that activates adenylyl cyclase (cAMP) and phospholipase C, including dopamine and adrenergic receptor pathways, as well as phototransduction. The common thread is GPCR signaling with downstream cAMP/PLC effects, alongside vision-related processes, suggesting a GPCR signaling module with diverse outputs. ","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010513","count":4},{"id":"GO:0043950","count":4},{"id":"GO:0071880","count":4},{"id":"GO:0007191","count":4},{"id":"GO:0007603","count":4}]},{"hash":"1104869348413450686","title":"DNA replication and organelle dynamics","description":"Although the top GO term is DNA replication, the cluster also includes terms related to centrosome/centriole elongation, microtubule dynamics, ER polarization, vesicle formation, peroxisome import, and chaperone-mediated assembly. This combination points to processes coordinating cell cycle progression with organelle biogenesis and intracellular trafficking, rather than a single enzyme function.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0034599","count":2},{"id":"GO:0039544","count":2},{"id":"GO:0031117","count":2},{"id":"GO:0061166","count":2}]},{"hash":"253643532681658719","title":"Fatty acid and lipid metabolism","description":"The top GO terms are dominated by lipid-related biosynthetic and catabolic processes, including methyl-branched fatty acid biosynthesis, fatty acid elongation, mycolic acid biosynthesis, and 3-keto-sphinganine metabolic process, plus related lipid pathways like retinal metabolism and tetrahydrobiopterin biosynthesis. This suggests the proteins in this cluster participate in lipid metabolism and lipid-derived molecule processing. A single term about regulation of DNA-templated transcription appears less central to the overall theme, so the label focuses on the lipid metabolism core.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":4},{"id":"GO:1902321","count":4},{"id":"GO:0006706","count":4},{"id":"GO:0006729","count":4},{"id":"GO:0045150","count":4}]},{"hash":"2106066178654440623","title":"Embryonic neural development and tissue morphogenesis","description":"The top GO terms cluster around embryogenesis with a focus on neural development and brain patterning (ectoderm formation, cerebral cortex regionalization, dopaminergic neuron differentiation), suggesting the proteins are involved in early tissue specification and neural differentiation, despite some broader morphogenesis terms present.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0048557","count":2},{"id":"GO:0035623","count":2},{"id":"GO:0021913","count":2},{"id":"GO:0045686","count":2}]},{"hash":"896533635170482421","title":"Unknown","description":"The top GO terms span plants, animals, and disparate processes (pituitary development, photosynthesis, redox metabolism, fungal response, copper import, erythrocyte differentiation, neural proliferation, inflammation) with no clear shared function or connectivity, so a coherent clustering label cannot be inferred from the data.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":3},{"id":"GO:0009854","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0060992","count":2},{"id":"GO:0006749","count":2}]},{"hash":"1005308534676181690","title":"Unknown","description":"The GO terms are highly diverse (RNA capping, quinone biosynthesis, post-translational dimethylation, stress responses, nodulation, and drug- or senescence-related processes) with no connecting edges, offering no single coherent function to tie the proteins together. As a result, there is no reliable common theme to label this cluster beyond Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":1},{"id":"GO:0006744","count":1},{"id":"GO:0035572","count":1},{"id":"GO:0006972","count":1},{"id":"GO:0042372","count":1}]},{"hash":"2141797832892925736","title":"Neural development and transcriptional regulation","description":"This cluster has several neural-development related terms (forebrain development, neural tube closure) along with broader development and DNA-templated transcription, suggesting a theme centered on developmental processes governed by transcriptional control. Some other terms reflect general stress or immune responses, which may be less representative, but the neural development signals dominate the set.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0006349","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0050830","count":2}]},{"hash":"736233047154261863","title":"Cellular stress response and organelle dynamics","description":"The top GO terms cluster around oxidative stress response, autophagy-related processes in endosomes, cadmium stress signaling, peroxisome protein import, ER polarization, microtubule dynamics, and broader organelle maintenance. This suggests a theme of cellular stress adaptation and reorganization of organelles, rather than a single enzymatic function. One term about competence for transformation is less related, but the overall pattern supports stress response and organelle dynamics as the cluster\u2019s core.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030420","count":3},{"id":"GO:0061738","count":3},{"id":"GO:0034599","count":3},{"id":"GO:0001319","count":3},{"id":"GO:0000733","count":3}]},{"hash":"1870302681693270835","title":"Unknown","description":"The GO terms are highly heterogeneous (glycosylation, signaling, energy metabolism, lipid biosynthesis, development), showing no clear single function to tie the proteins together.","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035269","count":1},{"id":"GO:0046329","count":1},{"id":"GO:0060049","count":1},{"id":"GO:0042775","count":1},{"id":"GO:2001246","count":1}]},{"hash":"440806327125090755","title":"Unknown","description":"The terms show regulatory functions in diverse contexts\u2014neural survival, cartilage differentiation, epithelial proliferation, immune sensing, and metabolic/secretory processes\u2014without a unifying biological function for the cluster.","confidence":"","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1903208","count":4},{"id":"GO:0032331","count":4},{"id":"GO:0050680","count":4},{"id":"GO:0071222","count":4},{"id":"GO:1905695","count":4}]},{"hash":"2148231392034786374","title":"Ubiquitination and NF-kappaB signaling regulators","description":"The shared terms center on ubiquitin-mediated processes (ubiquitin-dependent protein catabolic process, protein ubiquitination, autoubiquitination, various ubiquitin linkages) and activation of NF-kappaB signaling (NIK activity, I-kappaB phosphorylation), with histone ubiquitination as part of chromatin regulation. A peroxisome import term is present but less coherent with the main theme, which is dominated by ubiquitination and NF-kB pathway regulation.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0070535","count":4},{"id":"GO:2000620","count":4},{"id":"GO:0007250","count":4},{"id":"GO:0051865","count":4}]},{"hash":"698205726793452276","title":"Lipid Hormone Biosynthesis and Reproduction","description":"The cluster centers on lipid-derived signaling pathways (omega-hydroxylase and epoxygenase P450s, prostaglandin biosynthesis, calcitriol synthesis) and reproductive-related terms (prostate growth, sex differentiation, maternal parturition), suggesting a shared theme of lipid-mediated hormone production linked to reproductive development. One term (vancomycin biosynthesis) appears unrelated and may be noise.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060736","count":1},{"id":"GO:0033072","count":1},{"id":"GO:0036378","count":1},{"id":"GO:0097267","count":1},{"id":"GO:0006641","count":1}]},{"hash":"476161951516100978","title":"Ubiquitin-Dependent Protein Regulation & Histone Modification","description":"The cluster is dominated by GO terms related to ubiquitination (protein ubiquitination, ubiquitin-dependent protein catabolic process, autoubiquitination) and histone modification (histone ubiquitination, histone catabolic process, acetylation regulation), suggesting a shared role in ubiquitin-mediated regulation of proteins and chromatin. Some embryonic development terms may reflect broader roles of ubiquitin signaling in development. Overall, the common theme is ubiquitin-based regulation of proteins and histones.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":2},{"id":"GO:0042787","count":1},{"id":"GO:0070535","count":1},{"id":"GO:2000620","count":1},{"id":"GO:0007250","count":1}]},{"hash":"528796904720696910","title":"Unknown","description":"Top Terms are not given, so there is no detectable shared function among the four proteins to base a label on.","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[]},{"hash":"2281300866279864338","title":"Glycoprotein biosynthesis and modification","description":"Top GO terms are dominated by glycosylation-related processes (N-linked glycosylation via asparagine, dolichol-linked oligosaccharide biosynthetic, and GPI anchor biosynthetic processes) plus post-translational modification and glycoprotein catabolic process, indicating a cluster of proteins involved in glycoprotein production and processing. Some terms are obsolete or peripheral (e.g., pollen tube guidance), but they do not outweigh the main glycosylation signal.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018279","count":1},{"id":"GO:0045232","count":1},{"id":"GO:0043687","count":1},{"id":"GO:0043686","count":1},{"id":"GO:0006516","count":1}]},{"hash":"1618414807847564741","title":"Unknown","description":"The GO terms are highly heterogeneous, with themes spanning ubiquitin-dependent protein degradation and NF-kappaB signaling, immune cell differentiation, as well as skeletal muscle development, circadian rhythm, plant signaling, and locomotion. There isn\u2019t a single cohesive function that ties all terms together, so a specific label isn\u2019t justifiable.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0007250","count":2},{"id":"GO:0043380","count":1},{"id":"GO:0048741","count":1},{"id":"GO:0036268","count":1}]},{"hash":"1910864204645143861","title":"Megakaryocyte and platelet development","description":"The top GO terms point to megakaryocyte development and platelet formation, with supporting signals like cellular response to mechanical stimulus and ubiquitination that are relevant to platelet biology and differentiation. There are additional immune differentiation terms, but the core theme centers on megakaryopoiesis and platelet biogenesis. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0021707","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0010742","count":2},{"id":"GO:0030220","count":2}]},{"hash":"1001173009957839756","title":"Unknown","description":"The top GO terms point to a mix of unrelated processes (nucleophagy/autophagy, protein targeting to mitochondria, sumoylation, thiamine biosynthesis, development, and transcription regulation) and several are obsolete or species-specific, offering no clear common function. There isn\u2019t a cohesive theme uniting these annotations, so a specific, representative label isn\u2019t justifiable.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000746","count":1},{"id":"GO:0006627","count":1},{"id":"GO:0044805","count":1},{"id":"GO:0021764","count":1},{"id":"GO:0045892","count":1}]},{"hash":"457269838113505922","title":"Unknown","description":"The GO terms are highly diverse, spanning DNA replication, iron-sulfur assembly, chaperone-dependent refolding (obsolete), protein targeting to membranes, multiple apoptotic/stress regulation processes, fungal beta-glucan biosynthesis, and karyogamy. There is no single cohesive function linking these proteins, and with no edges connecting them, a specific label isn\u2019t warranted.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070389","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0016226","count":1},{"id":"GO:1902037","count":1},{"id":"GO:1903382","count":1}]},{"hash":"1871751446695775589","title":"mRNA Splicing and Processing Regulation","description":"These proteins cluster around spliceosome-mediated mRNA splicing, regulation of alternative splicing, and control of mRNA polyadenylation and stability. The GO terms emphasize post-transcriptional mRNA maturation and processing, rather than transcriptional regulation, suggesting a shared role in splicing and mRNA tail dynamics. Therefore, the label reflects the common theme of mRNA processing regulation.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":1},{"id":"GO:1900363","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0060211","count":1},{"id":"GO:0075522","count":1}]},{"hash":"504713723758596093","title":"Vesicle trafficking and exocytosis regulation","description":"The top terms cluster around secretory vesicle handling and transport: regulation of synaptic vesicle exocytosis, COPII-coated vesicle budding, and Golgi organization, all pointing to the secretory pathway and vesicle trafficking. Although some terms are deprecated, the common thread is regulation of vesicle formation, transport, and exocytosis, with additional related processes like synaptic transmission and cytoskeletal remodeling (podosome assembly) that connect to vesicle dynamics.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000300","count":3},{"id":"GO:0010796","count":3},{"id":"GO:0031384","count":3},{"id":"GO:0051932","count":2},{"id":"GO:0007030","count":2}]},{"hash":"45655642623943319","title":"Diverse Transmembrane Transport","description":"All top GO terms indicate membrane-transport functions across diverse substrates: nitrite and nitrate uptake, various sugar transports (galactose, arabinose, fucose), sodium and phosphate ion transport, vitamin transmembrane transport, and the vesicular neurotransmitter loading process; together they reflect a broader membrane transport role rather than a single pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015707","count":1},{"id":"GO:0042128","count":1},{"id":"GO:0006004","count":1},{"id":"GO:0035461","count":1},{"id":"GO:0042891","count":1}]},{"hash":"1717701921342754376","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":1},{"id":"GO:0019068","count":1},{"id":"GO:0030260","count":1},{"id":"GO:0015074","count":1},{"id":"GO:0000398","count":1}]},{"hash":"2002381421185680595","title":"Drosophila development, antenna morphogenesis, and sensory behavior","description":"GO terms point to embryonic development and body patterning (multicellular development, anterior/posterior pattern specification), antennal morphogenesis (arista elongation), plus sensory aspects (temperature detection, adult feeding behavior) and transcription regulation. This suggests a theme around developmental regulation coupled with antenna-related morphology and sensory responses in Drosophila, justifying a label that combines development, antenna morphogenesis, and sensory behavior.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0021501","count":1},{"id":"GO:0048557","count":1},{"id":"GO:0008343","count":1},{"id":"GO:0035015","count":1}]},{"hash":"428877097897312542","title":"Unknown","description":"The terms span very disparate processes\u2014male gonad development, pericardium morphogenesis, photomorphogenesis, keratinocyte differentiation, mucosal innate immunity, chromatin localization, and general protein interactions\u2014with several obsolete GO terms. There is no clear shared function or pathway linking these proteins, and the network has no edges, suggesting no cohesive cluster function. Therefore no concise, accurate label beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":1},{"id":"GO:0003344","count":1},{"id":"GO:2000306","count":1},{"id":"GO:0045618","count":1},{"id":"GO:0033128","count":1}]},{"hash":"351901798744710408","title":"Unknown","description":"The cluster has no GO term signals, edges, or shared functional themes to link the proteins, so no coherent function emerges. Without a unifying function, the appropriate label is Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1842446978363959379","title":"Ciliary assembly and intraciliary transport","description":"The cluster's top GO terms point to ciliogenesis (cilium assembly) and intraciliary retrograde transport, suggesting proteins involved in building cilia and moving cargo inside them. With only two terms represented once each and no known interactions, the signal is modest but centers on ciliary function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035721","count":1},{"id":"GO:0060271","count":1}]},{"hash":"350760832540239029","title":"Gonadal development and chromatin localization","description":"The cluster\u2019s GO terms prominently include male gonad development and oogenesis, plus cellular responses related to estradiol and a chromatin-associated process (establishment of protein localization to chromatin). These points collectively suggest a theme of reproductive development with an epigenetic/chromatin regulation angle. While some terms (innate mucosal immunity, keratinocyte differentiation) are more peripheral, they do not outweigh the central reproductive/chromatin pattern. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":1},{"id":"GO:0003344","count":1},{"id":"GO:0008285","count":1},{"id":"GO:0045618","count":1},{"id":"GO:0033128","count":1}]},{"hash":"1629614940855773835","title":"Ubiquitin-proteasome\u2013mediated protein degradation","description":"The top GO terms are dominated by ubiquitin-dependent protein catabolic processes and proteasome-mediated degradation, indicating the proteins in this cluster are primarily involved in targeted protein turnover via the ubiquitin-proteasome system. Other terms are present but peripheral, so the central theme is proteasome-driven protein catabolism.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":1},{"id":"GO:0033033","count":1},{"id":"GO:0045721","count":1},{"id":"GO:0043161","count":1},{"id":"GO:0048822","count":1}]},{"hash":"1797955476315727734","title":"Nucleolar ribosome biogenesis and cell cycle","description":"The top GO terms point to ribosome biogenesis (ribosomal large subunit biogenesis) and rRNA processing, with an additional link to nuclear division, suggesting a nucleolar role in ribosome assembly that supports cell cycle progression. Given the small cluster size and lack of interactions, the connection is plausible but not strongly reinforced by network structure alone.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":1},{"id":"GO:0006364","count":1},{"id":"GO:0000280","count":1}]},{"hash":"2235723322923660245","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034446","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0000472","count":1},{"id":"GO:0000480","count":1},{"id":"GO:0000447","count":1}]},{"hash":"192541746198386872","title":"Ribosome biogenesis and translation with p53 DNA damage response","description":"The top terms center on ribosomal large subunit biogenesis and translation, with accompanying p53-mediated DNA damage signaling and stress-responsive transcriptional regulation, suggesting a link between protein synthesis and DNA damage response.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0006977","count":2},{"id":"GO:0006353","count":2},{"id":"GO:0045727","count":2}]},{"hash":"1117935206414067774","title":"Nucleotide Salvage and Biosynthesis","description":"The GO terms show a clear emphasis on nucleotide metabolism, including AMP salvage, nucleotide phosphorylation, and purine ribonucleotide interconversion, along with related cofactor biosynthesis (NAD+ and CoA). The viral process annotation appears tangential to the core theme, so the label centers on nucleotide salvage and biosynthesis to reflect the cluster\u2019s dominant function.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0044209","count":3},{"id":"GO:0016032","count":2},{"id":"GO:0046940","count":2},{"id":"GO:0009435","count":2},{"id":"GO:0046705","count":2}]},{"hash":"804678168012383622","title":"Immune cell differentiation regulators","description":"The top GO terms point to immune development, with regulation of memory T cell differentiation, pro-T cell differentiation, and dendritic cell differentiation being prominent, suggesting these proteins collectively relate to immune cell lineage specification and control. Ubiquitination terms imply regulatory protein turnover in these pathways, while muscle development terms appear less central. Overall, the immune differentiation theme is the most representative across the terms.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":1},{"id":"GO:0043380","count":1},{"id":"GO:0048741","count":1},{"id":"GO:0007519","count":1},{"id":"GO:1900477","count":1}]},{"hash":"2275399616486144890","title":"Neural and cardiac development","description":"The GO terms point to differentiation of neural/cranial nerve and neuroendocrine lineages, plus heart-related development (glomus cells, oculomotor nerve, lung neuroendocrine cells, outflow tract morphogenesis, heart rate regulation). This suggests a shared theme of developmental differentiation across neural, cranial nerve, neuroendocrine, and cardiac tissues.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061103","count":3},{"id":"GO:0003062","count":3},{"id":"GO:2000820","count":3},{"id":"GO:0060165","count":3},{"id":"GO:0072277","count":3}]},{"hash":"2011840602554295002","title":"Neuronal Golgi and secretory vesicle trafficking","description":"Based on the dominant GO terms, the cluster seems centered on the secretory pathway, particularly Golgi organization and COPII-coated vesicle budding, with a neural development context (neural tube patterning and photoreceptor development). Some terms (mast cell chemotaxis, nuclear envelope organization) are less clearly connected and may reflect annotation breadth or noise in a small cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051932","count":2},{"id":"GO:0007030","count":2},{"id":"GO:0021532","count":2},{"id":"GO:0042461","count":2},{"id":"GO:0060753","count":2}]},{"hash":"2043844130411117737","title":"Neuronal signaling and synaptic plasticity with angiogenesis","description":"The cluster\u2019s strongest signals are neural-related: short-term memory and long-term potentiation point to synaptic plasticity, while regulation of heart rate suggests neurocardiovascular control, and angiogenesis adds a vascular development angle. Although a few terms diverge (e.g., skin development, stress response), the dominant themes tie neural signaling with vascular growth, supporting a label that captures both synaptic function and angiogenic processes.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002027","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0007614","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0006470","count":1}]},{"hash":"1805459194402120235","title":"Ion and Metabolite Transmembrane Transport","description":"The top GO terms are dominated by transmembrane transport activities for a variety of ions and metabolites (e.g., malate, succinate, citrate, arsenite, monoatomic anions) plus general ion and transmembrane transport terms, indicating a cluster of membrane transport proteins that shuttle small molecules and ions across membranes.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015743","count":2},{"id":"GO:0015700","count":2},{"id":"GO:0015744","count":2},{"id":"GO:0098656","count":2},{"id":"GO:0006814","count":2}]},{"hash":"100521101251221300","title":"Unknown","description":"The top terms include retrograde vesicle transport (Golgi to ER), cytokine production, RNA processing, peroxisome targeting, plant pattern formation, growth hormone response, and various developmental processes. This broad, disparate mix suggests no single coherent function or pathway defining the cluster, so a specific label cannot be confidently assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":2},{"id":"GO:0002534","count":1},{"id":"GO:0000348","count":1},{"id":"GO:0010255","count":1},{"id":"GO:0048568","count":1}]},{"hash":"1026939462884446168","title":"Unknown","description":"The GO terms span vesicle trafficking (exocytosis, phagocytosis), metabolism (nucleotide and sugar biosynthesis, fatty acid response), and differentiation signals (spermatid and keratinocyte), with no clear, single shared function linking all three proteins. This diversity suggests either diverse roles or annotation noise in this small cluster. ","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045920","count":3},{"id":"GO:0048515","count":3},{"id":"GO:0071333","count":3},{"id":"GO:0006183","count":3},{"id":"GO:0051259","count":3}]},{"hash":"1267463555391701209","title":"Fatty acid metabolism and organic acid catabolism","description":"The proteins in this cluster are enriched for a range of fatty acid\u2013related processes (long-chain, very long-chain, and medium-chain fatty-acyl-CoA metabolism), fatty acid import, and carnitine metabolism, suggesting a core theme of fatty acid handling. Additional GO terms point to various organic acid catabolic pathways (propionate, malonate, phenylacetate) and related metabolic steps, reinforcing a cohesive metabolic-catabolism cluster rather than a signaling or structural module. Overall, the dominant pattern is fatty acid and organic acid catabolism, justifying the label.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043041","count":2},{"id":"GO:0019654","count":2},{"id":"GO:0090410","count":2},{"id":"GO:0001676","count":2},{"id":"GO:0010124","count":2}]},{"hash":"451018690580798255","title":"Purine nucleotide metabolism","description":"The proteins show a clear enrichment for nucleotide-related GO terms, especially purine nucleotide phosphorylation, AMP salvage, and various biosynthetic and interconversion processes (ADP/GTP/CDP metabolism, purine ribonucleotide interconversion). While a couple development terms appear, the dominant pattern ties this cluster to purine nucleotide synthesis and salvage.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046940","count":3},{"id":"GO:0044209","count":3},{"id":"GO:0046705","count":3},{"id":"GO:0015951","count":3},{"id":"GO:0046041","count":3}]},{"hash":"2009890112822061687","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000738","count":1},{"id":"GO:0000289","count":1},{"id":"GO:0034415","count":1},{"id":"GO:0010606","count":1},{"id":"GO:0002107","count":1}]},{"hash":"1364474734152364265","title":"T Cell Development and Germinal Center Regulation","description":"The top GO terms are dominated by T cell\u2013related processes (T follicular helper cell differentiation, positive/negative regulation of T cell proliferation and memory T cell differentiation, and germinal center regulation), suggesting a core theme around T cell development and germinal center dynamics. Ubiquitin-dependent protein catabolic process may reflect general protein turnover during signaling; a couple of muscle development terms appear less connected, likely noise. Overall, the cluster appears to represent immune regulation centered on T cell maturation and germinal center activity.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0048294","count":2},{"id":"GO:0061470","count":2},{"id":"GO:0002635","count":2},{"id":"GO:0033092","count":2}]},{"hash":"1328332106829870024","title":"Embryonic neural and organ differentiation","description":"The terms point to differentiation events across multiple organs (carotid body glomus, oculomotor nerve, lung neuroendocrine cells, kidney glomerular capillaries) and developmental regulation (neural timing, heart outflow tract morphogenesis, Notch signaling in heart induction). This suggests a broad theme of embryonic tissue/organ differentiation across neural and cardiovascular systems, rather than a single specific pathway. Some terms are obsolete, but the overall pattern supports a developmental differentiation label.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061103","count":3},{"id":"GO:0003062","count":3},{"id":"GO:2000820","count":3},{"id":"GO:0060165","count":3},{"id":"GO:0072277","count":3}]},{"hash":"784478299879329359","title":"Histone Modification and Chromatin Silencing","description":"The top terms point to histone methylation marks (H3K9, H3K27, H4K20) and chromatin silencing/heterochromatin formation, suggesting epigenetic regulation roles. A few terms touch on Notch signaling and DNA damage response, but the dominant theme is chromatin regulation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006821","count":1},{"id":"GO:0045746","count":1},{"id":"GO:0036124","count":1},{"id":"GO:0000183","count":1},{"id":"GO:1902231","count":1}]},{"hash":"724815790129085149","title":"Integrin signaling and cell adhesion","description":"This cluster centers on adhesion-related signaling and cytoskeletal dynamics, with GO terms like integrin-mediated signaling, epithelial cell-cell adhesion, stress fiber assembly, and regulation of kinase activity, suggesting coordinated cell adhesion, migration, and modest morphogenetic roles (skin, endothelial, CNS). The diversity points to a broader adhesion-signaling module rather than a single narrowly defined process.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048146","count":1},{"id":"GO:0090136","count":1},{"id":"GO:0043588","count":1},{"id":"GO:2000406","count":1},{"id":"GO:0021551","count":1}]},{"hash":"1671091326942212127","title":"Endosome-to-lysosome trafficking","description":"The cluster is dominated by GO terms for endosome/lysosome transport and organization (endosome to lysosome transport, late endosome to lysosome transport, endosome and lysosome organization, intracellular protein transport, vesicle tethering), indicating a shared role in vesicular trafficking within the endocytic/lysosomal pathway. Some terms appear incidental (eye pigmentation, puparial adhesion), but the core pattern supports endosomal-lysosomal transport.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015721","count":1},{"id":"GO:0008333","count":1},{"id":"GO:0007594","count":1},{"id":"GO:0099022","count":1},{"id":"GO:1902774","count":1}]},{"hash":"359645761471665928","title":"Amino Acid and Central Metabolism","description":"This cluster centers on metabolic pathways, including L-methionine cycle, L-valine biosynthesis, one-carbon metabolism, methylamine metabolism, and D-galactarate catabolism, suggesting a shared theme of amino acid and carbon metabolism. Some terms such as oxidation-reduction, excretion, and inflammatory response appear but are less represented and may reflect annotation noise or broader functional links. Overall, the proteins are best described as involved in metabolic processing rather than a single specialized function.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0009854","count":2},{"id":"GO:0030416","count":2},{"id":"GO:0002439","count":2},{"id":"GO:0006730","count":2}]},{"hash":"2231513072361971262","title":"Neural crest and inner ear morphogenesis","description":"The GO terms center on vertebrate neural development and sensory organ formation, including neural crest cell development, retinoic acid receptor signaling, inner ear morphogenesis, and balance-related neuromuscular processes, suggesting a cohesive role in embryonic neural/sensory patterning. Some terms are more peripheral (metabolic processes), but the dominant theme is neural crest\u2013driven development of sensory structures.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048384","count":3},{"id":"GO:0042472","count":3},{"id":"GO:0009954","count":3},{"id":"GO:0019285","count":3},{"id":"GO:0009450","count":3}]},{"hash":"77295060101804165","title":"Bacterial Biosynthetic Pathways","description":"The top GO terms cluster around diverse biosynthetic processes in bacteria, including poly-hydroxybutyrate, lipopolysaccharide core and O antigen biosynthesis, fatty acid and sugar biosynthesis, and antibiotic biosynthesis, which together suggest a common theme of bacterial metabolite production and cell-envelope assembly.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042619","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0009244","count":2},{"id":"GO:0006355","count":2}]},{"hash":"2125039659605486945","title":"Meiosis-associated chromatin and division","description":"The top GO terms point to chromatin organization and modification (e.g., chiasma assembly, heterochromatin formation, histone-related processes) and links to cell division, with meiosis-specific processes suggested by chiasma assembly. Although some terms are obsolete or broader (e.g., apoptotic process, peroxisome import), the core signal across the terms suggests a theme around chromatin regulation during meiosis and cell division.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0051026","count":3},{"id":"GO:0033128","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0060340","count":3},{"id":"GO:0016562","count":3}]},{"hash":"2112054050938654609","title":"Embryonic development and cell cycle regulation","description":"These proteins show enrichment for developmental processes (third ventricle development, neural tube closure, skin development, multicellular organism development) as well as growth control and genome integrity (negative regulation of cell proliferation, mitotic G1 DNA damage checkpoint signaling, ubiquitination regulation). The mix points to factors coordinating developmental programs with cell-cycle control and chromatin regulation during development, rather than a single specific function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021678","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0070544","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0021993","count":2}]},{"hash":"170393713455159957","title":"Unknown","description":"There are no GO terms listed and no interactions among the proteins (isolated nodes). Without a shared functional annotation or network pattern, there is no clear theme to justify a functional label.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"178953341517119851","title":"Meiotic recombination and DNA repair","description":"The GO terms cluster around meiotic events and homologous recombination\u2014DNA strand invasion, meiotic recombinase assembly, joint molecule formation, gene conversion at the mating-type locus, and repair of double-strand breaks by homologous recombination\u2014plus cellular response to ionizing radiation. These terms indicate a coherent meiotic recombination/double-strand break repair function for the proteins, with a couple unrelated terms likely incidental.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042148","count":1},{"id":"GO:0010772","count":1},{"id":"GO:0043388","count":1},{"id":"GO:0000724","count":1},{"id":"GO:0000709","count":1}]},{"hash":"1698988490311914261","title":"Unknown","description":"There is no connecting information: zero edges, zero triangles, and no GO terms to guide a functional label. With no shared function across the proteins, the cluster cannot be confidently characterized; label Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1309213806082863411","title":"Chromatin organization and heterochromatin formation","description":"The top GO terms point to chromatin-related processes, including chiasma assembly and silent mating-type cassette heterochromatin formation, as well as histone modification terms. Although some entries are obsolete, the recurring theme is regulation of chromatin structure and heterochromatin, which best explains this cluster's functional focus.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0051026","count":3},{"id":"GO:0033128","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0060340","count":3},{"id":"GO:0016562","count":3}]},{"hash":"1329257984281875743","title":"Biosynthesis and RNA modification","description":"The GO terms are largely centered on biosynthetic processes (mRNA capping, ubiquinone, biotin, sterol biosynthesis) and RNA modification (rRNA guanine-N7 methylation), suggesting a functional theme around metabolic production and RNA-processing activities. Some terms like cellular senescence or nodulation are outliers, but the dominant pattern points to biosynthesis and RNA-modifying capabilities.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":1},{"id":"GO:0006744","count":1},{"id":"GO:0090398","count":1},{"id":"GO:0009102","count":1},{"id":"GO:0042418","count":1}]},{"hash":"1074600112719989051","title":"Embryogenesis and body axis patterning","description":"The top GO terms center on embryonic development and patterning along the body axes (in utero embryonic development, left/right pattern formation, rostrocaudal neural tube patterning), with some ubiquitination-related terms suggesting protein regulation during development. While immune-related terms appear, the dominant signal is developmental patterning. ","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061470","count":2},{"id":"GO:0002635","count":2},{"id":"GO:0033092","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0060972","count":2}]},{"hash":"561128110129885656","title":"DNA repair and genome maintenance regulators","description":"The top GO terms cluster around DNA topology/modification and genome maintenance processes (topoisomerase regulation, histone modification, DSB repair via NHEJ, DNA recombination/integration). This suggests a functional group involved in maintaining genome integrity and DNA processing, despite some peripheral development-related terms appearing as noise.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000373","count":1},{"id":"GO:0097676","count":1},{"id":"GO:2001034","count":1},{"id":"GO:0006310","count":1},{"id":"GO:0090305","count":1}]},{"hash":"1379716538517506486","title":"Viral integration and transposon activity","description":"The cluster's top GO terms center on host-virus interactions and genome integration: entry/penetration into host cells, establishment of proviral latency, DNA integration and transposition, and retrotransposition. This suggests a cohesive theme around viral genomes and transposable elements integrating into and influencing the host genome, with latency and transcriptional regulation aspects.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0006313","count":2}]},{"hash":"2151927370555532094","title":"Fungal cell wall biosynthesis","description":"The cluster shows multiple terms tied to fungal cell wall construction (slime layer polysaccharides, cell wall biogenesis, mannoprotein and sugar-nucleotide biosynthesis) and related morphogenesis, suggesting proteins function in assembling and shaping the fungal cell wall.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045228","count":1},{"id":"GO:0071555","count":1},{"id":"GO:0000032","count":1},{"id":"GO:0019877","count":1},{"id":"GO:0009272","count":1}]},{"hash":"1193005016592086888","title":"Unknown","description":"The cluster contains GO terms for endothelial cell proliferation and DNA transposition, which do not share a coherent, common function. With only two disparate terms across three proteins, there isn\u2019t a clear biological theme to assign a specific label, so Unknown is most appropriate.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001935","count":1},{"id":"GO:0006313","count":1}]},{"hash":"1277273141327572844","title":"Environmental Stress Response","description":"The top GO terms cluster around cellular responses to various stressors (corticosterone, cold, fungicide, LPS) and related outcomes such as apoptosis, with some neural development signaling; the common thread appears to be mounting responses to environmental or physiological stress rather than a single, specific pathway. Confidence in this broad-stress interpretation is moderate due to term diversity and sparse connectivity.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051412","count":2},{"id":"GO:0060992","count":2},{"id":"GO:0009409","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0042135","count":2}]},{"hash":"660565090766205787","title":"Ubiquitin-Dependent Degradation and Histone Ubiquitination","description":"The top GO terms are dominated by ubiquitination processes (ubiquitin-dependent protein catabolic process, protein ubiquitination, autoubiquitination) and histone ubiquitination/modification, with NF-kappaB signaling also present. This points to a function in ubiquitin-mediated protein turnover and chromatin modification, with a possible oxidative stress linkage via hydrogen peroxide response.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0070301","count":3},{"id":"GO:0070535","count":2},{"id":"GO:2000620","count":2}]},{"hash":"604679331735149670","title":"Unknown","description":"The GO terms are a scattered mix across different biological areas (ectoine and acetoin metabolism, various N-terminal acetylation/propionylation processes, glucosamine/N-acetylglucosamine metabolism, and leaf formation regulation), with no clear, shared function tying all three proteins together. It\u2019s not possible to derive a single coherent label from these terms, so the cluster is best described as Unknown.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019491","count":3},{"id":"GO:0030187","count":3},{"id":"GO:0017196","count":3},{"id":"GO:0045150","count":3},{"id":"GO:0018002","count":3}]},{"hash":"1522828932868433424","title":"Diverse organic compound catabolism","description":"The GO terms cluster around breakdown and detoxification of a wide range of organic molecules (e.g., organohalides, lipids, glucuronosides, beta-ketoadipate pathway) and related biosynthetic processes (biotin, strigolactone), plus detoxification and insect defense signals. There isn\u2019t a single unified pathway, but the common thread is metabolism and detox of diverse compounds, with some plant-defense associations; hence a broad \u201cdiverse organic compound catabolism\u201d label best fits this cluster.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019260","count":3},{"id":"GO:0019433","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0002213","count":3},{"id":"GO:0019391","count":3}]},{"hash":"1678703306448118494","title":"Unknown","description":"The terms span diverse nuclear and developmental processes (DNA transcription regulation, spindle orientation, nuclear migration, nuclear pore assembly) and gametogenesis (oogenesis, sperm individualization) plus apoptosis, with no clear shared pathway among the isolated proteins, so a single cohesive function is not evident.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:1900740","count":1},{"id":"GO:1904801","count":1},{"id":"GO:0000132","count":1},{"id":"GO:0006915","count":1}]},{"hash":"1683116593970747766","title":"Unknown","description":"The GO terms show a mix of bacteriochlorophyll biosynthesis, oxidative stress and SOS responses, transcription regulation, microtubule dynamics, ER polarization, vesicle formation, and chaperone assembly. This wide spread across prokaryotic and eukaryotic processes yields no coherent single function for the cluster.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030494","count":2},{"id":"GO:0034599","count":2},{"id":"GO:0039544","count":2},{"id":"GO:0045892","count":2},{"id":"GO:0009432","count":2}]},{"hash":"1330103371793338509","title":"Unknown","description":"The top GO terms cover a highly diverse mix of reproductive processes, neural/behavioral signals, immune/cytokine activity, hormone secretion, and basic protein processing, with no clear unifying function or pathway connecting them. Given the small cluster size and disparate terms, there is no coherent theme to label a specific function.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035180","count":1},{"id":"GO:0001920","count":1},{"id":"GO:0007339","count":1},{"id":"GO:0042089","count":1},{"id":"GO:0034230","count":1}]},{"hash":"2124223078264158485","title":"Unknown","description":"This cluster's GO terms are scattered across diverse processes (male gonad development; redox homeostasis; various metabolic and biosynthetic processes; erythrocyte and osteoclast-related regulation) with no clear overarching function, and there are no edges connecting the proteins, so a cohesive, specific label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":1},{"id":"GO:0045454","count":1},{"id":"GO:0030416","count":1},{"id":"GO:0017004","count":1},{"id":"GO:0019471","count":1}]}]