{"hash":"907289591087252365","title":"Endocytosis and vesicle trafficking","description":"The cluster is dominated by GO terms related to endocytosis, Golgi-to-endosome transport, and clathrin-mediated vesicle trafficking, with additional notes on actin dynamics (Arp2/3 regulation) and receptor signaling modulation (EGFR/PDGFR pathways). While a couple terms are broader or less directly tied (e.g., iron import, storage protein import), the strongest signal is endocytic trafficking and its regulation by the actin cytoskeleton, which likely coordinates receptor signaling and membrane transport. This makes the label Endocytosis and vesicle trafficking a concise, representative theme for the cluster.","confidence":"High","size":16,"edges":116,"triangles":510,"max_degree":15,"top_function":null,"members":[{"accession":"XP_004949853.2","go_terms":["GO:0031954","GO:1901998","GO:0043328","GO:0016192","GO:0006895","GO:0090160","GO:0099590","GO:1900126","GO:0035652","GO:0035646","GO:0006886","GO:0043323","GO:2000274","GO:0006622","GO:1903551","GO:0031321","GO:1903543","GO:0045053","GO:0045743","GO:0045752","GO:1904669"]},{"accession":"NP_001073230.2","go_terms":["GO:2000369","GO:0072583","GO:0098711","GO:0035459","GO:0048268","GO:0034316","GO:0048260","GO:0048261","GO:0016188","GO:0045742","GO:1905445","GO:0006919","GO:0006915","GO:1902963","GO:0055123","GO:0060453","GO:1901030","GO:1902961","GO:2000588","GO:1902004","GO:0032511","GO:0006897","GO:0006895","GO:0007565","GO:0006623","GO:0071985","GO:0000147","GO:0009997","GO:0015032","GO:0034498"]},{"accession":"XP_015136238.2","go_terms":["GO:2000369","GO:0072583","GO:0098711","GO:0035459","GO:0048268","GO:0034316","GO:0048260","GO:0048261","GO:0016188","GO:0045742","GO:1905445","GO:0006919","GO:0006915","GO:1902963","GO:0055123","GO:0060453","GO:1901030","GO:1902961","GO:2000588","GO:1902004","GO:0032511","GO:0006897","GO:0006895","GO:0007565","GO:0006623","GO:0071985","GO:0000147","GO:0009997","GO:0015032","GO:0034498"]},{"accession":"XP_015140134.2","go_terms":["GO:2000369","GO:0072583","GO:0098711","GO:0035459","GO:0048268","GO:0034316","GO:0048260","GO:0048261","GO:0016188","GO:0045742","GO:1905445","GO:0006919","GO:0006915","GO:1902963","GO:0055123","GO:0060453","GO:1901030","GO:1902961","GO:2000588","GO:1902004","GO:0032511","GO:0006897","GO:0006895","GO:0007565","GO:0006623","GO:0071985","GO:0000147","GO:0009997","GO:0015032","GO:0034498"]},{"accession":"XP_040553232.1","go_terms":["GO:2000369","GO:0072583","GO:0098711","GO:0035459","GO:0048268","GO:0034316","GO:0048260","GO:0048261","GO:0016188","GO:0045742","GO:1905445","GO:0006919","GO:0006915","GO:1902963","GO:0055123","GO:0060453","GO:1901030","GO:1902961","GO:2000588","GO:1902004","GO:0032511","GO:0006897","GO:0006895","GO:0007565","GO:0006623","GO:0071985","GO:0000147","GO:0009997","GO:0015032","GO:0034498"]},{"accession":"NP_001012806.1","go_terms":["GO:2000369","GO:0072583","GO:0098711","GO:0035459","GO:0048268","GO:0034316","GO:0048260","GO:0048261","GO:0016188","GO:0045742","GO:1905445","GO:0006919","GO:0006915","GO:1902963","GO:0055123","GO:0060453","GO:1901030","GO:1902961","GO:2000588","GO:1902004","GO:0032511","GO:0006897","GO:0006895","GO:0007565","GO:0006623","GO:0071985","GO:0000147","GO:0009997","GO:0015032","GO:0034498"]},{"accession":"NP_001012855.2","go_terms":["GO:0006897","GO:0006858"]},{"accession":"NP_001012969.3","go_terms":["GO:2000369","GO:0072583","GO:0098711","GO:0035459","GO:0048268","GO:0034316","GO:0048260","GO:0048261","GO:0016188","GO:0045742","GO:1905445","GO:0006919","GO:0006915","GO:1902963","GO:0055123","GO:0060453","GO:1901030","GO:1902961","GO:2000588","GO:1902004","GO:0032511","GO:0006897","GO:0006895","GO:0007565","GO:0006623","GO:0071985","GO:0000147","GO:0009997","GO:0015032","GO:0034498"]},{"accession":"NP_001170886.2","go_terms":["GO:2000369","GO:0046856","GO:0090071","GO:0090344","GO:0030336","GO:0090160","GO:0060024","GO:0061002","GO:0060044","GO:0060736","GO:0051898","GO:0031174","GO:0060134","GO:0002902","GO:0051895","GO:0007436","GO:0009556","GO:0031658","GO:0097107","GO:0097105","GO:0048681","GO:0046855","GO:0006470","GO:1903984","GO:0048853","GO:0010761","GO:0060997","GO:0033032","GO:2000463","GO:0031104","GO:0021542","GO:0031271","GO:0060074","GO:0036052","GO:1903669","GO:0007425","GO:0031642","GO:0045792","GO:0042711","GO:0016191","GO:0090394","GO:0031647","GO:0032286","GO:2000060","GO:0007044","GO:0048286","GO:0014850","GO:2000808","GO:0034461","GO:1905224"]},{"accession":"XP_024997618.1","go_terms":["GO:2000369","GO:0072583","GO:0098711","GO:0035459","GO:0048268","GO:0034316","GO:0048260","GO:0048261","GO:0016188","GO:0045742","GO:1905445","GO:0006919","GO:0006915","GO:1902963","GO:0055123","GO:0060453","GO:1901030","GO:1902961","GO:2000588","GO:1902004","GO:0032511","GO:0006897","GO:0006895","GO:0007565","GO:0006623","GO:0071985","GO:0000147","GO:0009997","GO:0015032","GO:0034498"]},{"accession":"XP_015133806.1","go_terms":["GO:2000369","GO:0072583","GO:0098711","GO:0035459","GO:0048268","GO:0034316","GO:0048260","GO:0048261","GO:0016188","GO:0045742","GO:1905445","GO:0006919","GO:0006915","GO:1902963","GO:0055123","GO:0060453","GO:1901030","GO:1902961","GO:2000588","GO:1902004","GO:0032511","GO:0006897","GO:0006895","GO:0007565","GO:0006623","GO:0071985","GO:0000147","GO:0009997","GO:0015032","GO:0034498"]},{"accession":"XP_015151002.1","go_terms":["GO:2000369","GO:0072583","GO:0098711","GO:0035459","GO:0048268","GO:0034316","GO:0048260","GO:0048261","GO:0016188","GO:0045742","GO:1905445","GO:0006919","GO:0006915","GO:1902963","GO:0055123","GO:0060453","GO:1901030","GO:1902961","GO:2000588","GO:1902004","GO:0032511","GO:0006897","GO:0006895","GO:0007565","GO:0006623","GO:0071985","GO:0000147","GO:0009997","GO:0015032","GO:0034498"]},{"accession":"XP_015151650.2","go_terms":["GO:1903358","GO:0006907","GO:2001137","GO:0035023","GO:1903861","GO:0048488","GO:0007120","GO:0007121","GO:0090160","GO:0060990","GO:1901387","GO:2000601","GO:0030476","GO:0000147","GO:0030100","GO:0007015","GO:0071363","GO:0086036","GO:0050731","GO:0010886","GO:0097320","GO:1901741","GO:0032456"]},{"accession":"XP_046798849.1","go_terms":["GO:0061341","GO:0003146","GO:0071474"]},{"accession":"XP_015136214.2","go_terms":["GO:2000369","GO:0072583","GO:0098711","GO:0035459","GO:0048268","GO:0034316","GO:0048260","GO:0048261","GO:0016188","GO:0045742","GO:1905445","GO:0006919","GO:0006915","GO:1902963","GO:0055123","GO:0060453","GO:1901030","GO:1902961","GO:2000588","GO:1902004","GO:0032511","GO:0006897","GO:0006895","GO:0007565","GO:0006623","GO:0071985","GO:0000147","GO:0009997","GO:0015032","GO:0034498"]},{"accession":"NP_001025786.2","go_terms":["GO:2000369","GO:0072583","GO:0098711","GO:0035459","GO:0048268","GO:0034316","GO:0048260","GO:0048261","GO:0016188","GO:0045742","GO:1905445","GO:0006919","GO:0006915","GO:1902963","GO:0055123","GO:0060453","GO:1901030","GO:1902961","GO:2000588","GO:1902004","GO:0032511","GO:0006897","GO:0006895","GO:0007565","GO:0006623","GO:0071985","GO:0000147","GO:0009997","GO:0015032","GO:0034498"]}],"graph":[["NP_001012806.1","NP_001073230.2",0.6],["NP_001012806.1","NP_001170886.2",0.694],["NP_001012806.1","NP_001012855.2",0.698],["NP_001012806.1","NP_001012969.3",0.572],["NP_001012806.1","NP_001025786.2",0.642],["NP_001012806.1","XP_015140134.2",0.541],["NP_001012806.1","XP_015136214.2",0.576],["NP_001012806.1","XP_015136238.2",0.58],["NP_001012806.1","XP_015133806.1",0.586],["NP_001012806.1","XP_004949853.2",0.678],["NP_001012806.1","XP_040553232.1",0.546],["NP_001012806.1","XP_024997618.1",0.562],["NP_001012806.1","XP_015151002.1",0.545],["NP_001012806.1","XP_015151650.2",0.668],["XP_024997618.1","XP_004949853.2",0.699],["XP_024997618.1","XP_015133806.1",0.652],["XP_024997618.1","XP_015136214.2",0.64],["XP_024997618.1","XP_015136238.2",0.648],["XP_024997618.1","XP_015140134.2",0.634],["XP_024997618.1","XP_015151002.1",0.593],["XP_024997618.1","XP_015151650.2",0.697],["XP_024997618.1","XP_040553232.1",0.632],["XP_024997618.1","XP_046798849.1",0.516],["XP_024997618.1","NP_001012855.2",0.716],["XP_024997618.1","NP_001012969.3",0.643],["XP_024997618.1","NP_001025786.2",0.686],["XP_024997618.1","NP_001073230.2",0.672],["XP_024997618.1","NP_001170886.2",0.729],["XP_040553232.1","XP_004949853.2",0.707],["XP_040553232.1","XP_015133806.1",0.636],["XP_040553232.1","XP_015136214.2",0.639],["XP_040553232.1","XP_015136238.2",0.639],["XP_040553232.1","XP_015140134.2",0.604],["XP_040553232.1","XP_015151002.1",0.614],["XP_040553232.1","XP_015151650.2",0.717],["XP_040553232.1","NP_001012855.2",0.739],["XP_040553232.1","NP_001012969.3",0.619],["XP_040553232.1","NP_001025786.2",0.7],["XP_040553232.1","NP_001073230.2",0.657],["XP_040553232.1","NP_001170886.2",0.749],["XP_046798849.1","XP_004949853.2",0.603],["XP_046798849.1","XP_015133806.1",0.542],["XP_046798849.1","XP_015136214.2",0.526],["XP_046798849.1","XP_015136238.2",0.531],["XP_046798849.1","XP_015151650.2",0.638],["XP_046798849.1","NP_001012855.2",0.676],["XP_046798849.1","NP_001012969.3",0.527],["XP_046798849.1","NP_001025786.2",0.583],["XP_046798849.1","NP_001073230.2",0.576],["XP_046798849.1","NP_001170886.2",0.647],["XP_015133806.1","XP_015151002.1",0.638],["XP_015133806.1","XP_015151650.2",0.695],["XP_015133806.1","NP_001012855.2",0.74],["XP_015133806.1","NP_001012969.3",0.651],["XP_015133806.1","NP_001025786.2",0.692],["XP_015133806.1","NP_001073230.2",0.631],["XP_015133806.1","NP_001170886.2",0.764],["XP_015133806.1","XP_004949853.2",0.704],["XP_015133806.1","XP_015136214.2",0.629],["XP_015133806.1","XP_015136238.2",0.632],["XP_015133806.1","XP_015140134.2",0.643],["NP_001025786.2","NP_001012855.2",0.746],["NP_001025786.2","NP_001012969.3",0.713],["NP_001025786.2","NP_001073230.2",0.716],["NP_001025786.2","NP_001170886.2",0.77],["NP_001025786.2","XP_004949853.2",0.754],["NP_001025786.2","XP_015136214.2",0.707],["NP_001025786.2","XP_015136238.2",0.712],["NP_001025786.2","XP_015140134.2",0.702],["NP_001025786.2","XP_015151002.1",0.679],["NP_001025786.2","XP_015151650.2",0.742],["NP_001073230.2","NP_001012855.2",0.719],["NP_001073230.2","NP_001012969.3",0.671],["NP_001073230.2","NP_001170886.2",0.773],["NP_001073230.2","XP_004949853.2",0.71],["NP_001073230.2","XP_015136214.2",0.644],["NP_001073230.2","XP_015136238.2",0.645],["NP_001073230.2","XP_015140134.2",0.659],["NP_001073230.2","XP_015151002.1",0.66],["NP_001073230.2","XP_015151650.2",0.711],["NP_001012969.3","NP_001170886.2",0.756],["NP_001012969.3","NP_001012855.2",0.739],["NP_001012969.3","XP_015140134.2",0.619],["NP_001012969.3","XP_015136214.2",0.655],["NP_001012969.3","XP_015136238.2",0.653],["NP_001012969.3","XP_004949853.2",0.715],["NP_001012969.3","XP_015151002.1",0.631],["NP_001012969.3","XP_015151650.2",0.724],["XP_015151650.2","XP_004949853.2",0.734],["XP_015151650.2","XP_015136214.2",0.694],["XP_015151650.2","XP_015136238.2",0.71],["XP_015151650.2","XP_015140134.2",0.726],["XP_015151650.2","XP_015151002.1",0.689],["XP_015151650.2","NP_001012855.2",0.728],["XP_015151650.2","NP_001170886.2",0.757],["XP_015140134.2","XP_015151002.1",0.616],["XP_015140134.2","NP_001012855.2",0.754],["XP_015140134.2","NP_001170886.2",0.743],["XP_015140134.2","XP_004949853.2",0.708],["XP_015140134.2","XP_015136214.2",0.639],["XP_015140134.2","XP_015136238.2",0.641],["NP_001012855.2","NP_001170886.2",0.782],["NP_001012855.2","XP_015136214.2",0.737],["NP_001012855.2","XP_015136238.2",0.756],["NP_001012855.2","XP_004949853.2",0.719],["NP_001012855.2","XP_015151002.1",0.711],["XP_015136214.2","XP_015151002.1",0.629],["XP_015136214.2","NP_001170886.2",0.753],["XP_015136214.2","XP_004949853.2",0.701],["XP_015136214.2","XP_015136238.2",0.642],["XP_015151002.1","XP_004949853.2",0.694],["XP_015151002.1","XP_015136238.2",0.64],["XP_015151002.1","NP_001170886.2",0.72],["XP_004949853.2","NP_001170886.2",0.783],["XP_004949853.2","XP_015136238.2",0.707],["XP_015136238.2","NP_001170886.2",0.766]],"all_go_terms":{"GO:0045743":1,"GO:1903551":1,"GO:1901998":1,"GO:0045752":1,"GO:0016192":1,"GO:0006886":1,"GO:0035646":1,"GO:0043323":1,"GO:1904669":1,"GO:1903543":1,"GO:1900126":1,"GO:0043328":1,"GO:0006895":12,"GO:0035652":1,"GO:0045053":1,"GO:0090160":3,"GO:0099590":1,"GO:0031954":1,"GO:0006622":1,"GO:0031321":1,"GO:2000274":1,"GO:0045742":11,"GO:0000147":12,"GO:2000588":11,"GO:0034316":11,"GO:0007565":11,"GO:0098711":11,"GO:0015032":11,"GO:1905445":11,"GO:0034498":11,"GO:0032511":11,"GO:0016188":11,"GO:2000369":12,"GO:0048261":11,"GO:1901030":11,"GO:0006897":12,"GO:0072583":11,"GO:0009997":11,"GO:0035459":11,"GO:0048260":11,"GO:1902004":11,"GO:0048268":11,"GO:0071985":11,"GO:0055123":11,"GO:0006623":11,"GO:0006915":11,"GO:1902961":11,"GO:0006919":11,"GO:0060453":11,"GO:1902963":11,"GO:0006858":1,"GO:0031647":1,"GO:0061002":1,"GO:0060024":1,"GO:0034461":1,"GO:0032286":1,"GO:0048286":1,"GO:0045792":1,"GO:0033032":1,"GO:2000463":1,"GO:0009556":1,"GO:1905224":1,"GO:0051898":1,"GO:0007044":1,"GO:2000808":1,"GO:0046856":1,"GO:0006470":1,"GO:0051895":1,"GO:0060134":1,"GO:0048853":1,"GO:0031658":1,"GO:0010761":1,"GO:0090394":1,"GO:0042711":1,"GO:0030336":1,"GO:0090344":1,"GO:0097107":1,"GO:0048681":1,"GO:0046855":1,"GO:0031271":1,"GO:0007436":1,"GO:0090071":1,"GO:0036052":1,"GO:0031642":1,"GO:0031174":1,"GO:0060074":1,"GO:1903984":1,"GO:1903669":1,"GO:0014850":1,"GO:0002902":1,"GO:0021542":1,"GO:0060044":1,"GO:0097105":1,"GO:0007425":1,"GO:0016191":1,"GO:2000060":1,"GO:0060997":1,"GO:0031104":1,"GO:0060736":1,"GO:2001137":1,"GO:2000601":1,"GO:1901741":1,"GO:0006907":1,"GO:1901387":1,"GO:0007120":1,"GO:0048488":1,"GO:0050731":1,"GO:0097320":1,"GO:0030476":1,"GO:0010886":1,"GO:0032456":1,"GO:0007121":1,"GO:0060990":1,"GO:0086036":1,"GO:1903358":1,"GO:0007015":1,"GO:0071363":1,"GO:0035023":1,"GO:1903861":1,"GO:0030100":1,"GO:0071474":1,"GO:0061341":1,"GO:0003146":1},"recipe_readded":[]}