{"hash":"162186015113517497","title":"Vesicle Trafficking and Immune Cell Degranulation","description":"The cluster is strongly associated with GO terms for protein and vesicle transport, including Golgi-to-ER and endosome-to-Golgi retrograde trafficking, intra-Golgi transport, vesicle targeting, vacuole fusion, and degranulation in neutrophils and NK cells. This points to a common function in intracellular vesicle trafficking and exocytosis, particularly related to immune cell granule release. Some terms like triglyceride transport and dendrite morphogenesis appear as minor outliers, but do not override the dominant vesicle transport/degranulation theme.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"members":[{"accession":"NP_001006526.1","go_terms":["GO:0006903","GO:0034197","GO:0043308","GO:0006888","GO:0043320","GO:1990668","GO:0042144","GO:0042147","GO:0050775","GO:0006891","GO:0006890","GO:0043312","GO:0048280","GO:1903595","GO:0015031","GO:0035493","GO:1900483"]},{"accession":"NP_989494.2","go_terms":["GO:2001234","GO:0000045","GO:0032436","GO:0015871","GO:0043524","GO:0051563","GO:0007219","GO:0060999","GO:0034205","GO:0007613","GO:0007175","GO:0007286","GO:0006839","GO:0001756","GO:0018991","GO:0070588","GO:0003407","GO:0050820","GO:0048167","GO:0001764","GO:0035556","GO:0002286","GO:0001568","GO:0048705","GO:0060070","GO:0060075","GO:0051444","GO:0007220","GO:0007420","GO:0051966","GO:0043393","GO:0043011","GO:0009791","GO:0043406","GO:1904797","GO:0030326","GO:0001708","GO:0001947","GO:0006509","GO:0021795","GO:0033160","GO:0031149","GO:0016080","GO:0006974","GO:0016485","GO:0006979","GO:0061053","GO:0050771","GO:0050673","GO:0000186","GO:0016337","GO:0021904","GO:0015813","GO:0021987","GO:0006486","GO:2000059","GO:0043065","GO:0002244","GO:0048538","GO:0044671","GO:0001921","GO:0021870","GO:0043589","GO:0048666","GO:0050852","GO:0006914","GO:0051402","GO:0022008","GO:0007507","GO:0048854","GO:0030900","GO:0015031"]},{"accession":"NP_001257645.1","go_terms":[]},{"accession":"XP_015151470.1","go_terms":[]},{"accession":"NP_001006350.1","go_terms":[]},{"accession":"XP_040504008.2","go_terms":[]},{"accession":"XP_415401.2","go_terms":["GO:0032623","GO:1903044","GO:1901585","GO:0007007","GO:1903905","GO:0000001","GO:0072249","GO:0032226","GO:0022617","GO:0045541","GO:0070584","GO:0032933","GO:0060355","GO:0007588","GO:0052547","GO:1990046","GO:0034141","GO:0030433","GO:0010876","GO:0010918","GO:0090297","GO:0001302","GO:2000049","GO:1900210","GO:0070528","GO:0045861"]},{"accession":"NP_001264934.1","go_terms":["GO:0006895","GO:0000042","GO:0043001"]},{"accession":"XP_424816.3","go_terms":["GO:0030148","GO:0007254","GO:0071529","GO:0007249","GO:0045070","GO:0030497","GO:0046726","GO:0007266","GO:0042761"]}],"graph":[["XP_015151470.1","XP_040504008.2",0.697],["XP_015151470.1","XP_415401.2",0.695],["XP_015151470.1","XP_424816.3",0.714],["XP_015151470.1","NP_001006350.1",0.718],["XP_015151470.1","NP_001006526.1",0.698],["XP_015151470.1","NP_001257645.1",0.727],["XP_015151470.1","NP_001264934.1",0.684],["XP_015151470.1","NP_989494.2",0.708],["XP_040504008.2","XP_415401.2",0.718],["XP_040504008.2","XP_424816.3",0.759],["XP_040504008.2","NP_001006350.1",0.667],["XP_040504008.2","NP_001006526.1",0.675],["XP_040504008.2","NP_001257645.1",0.691],["XP_040504008.2","NP_001264934.1",0.687],["XP_040504008.2","NP_989494.2",0.706],["NP_001006526.1","NP_001006350.1",0.693],["NP_001006526.1","NP_989494.2",0.738],["NP_001006526.1","NP_001264934.1",0.74],["NP_001006526.1","NP_001257645.1",0.696],["NP_001006526.1","XP_424816.3",0.711],["NP_001006526.1","XP_415401.2",0.71],["NP_001257645.1","NP_001006350.1",0.703],["NP_001257645.1","NP_989494.2",0.703],["NP_001257645.1","NP_001264934.1",0.645],["NP_001257645.1","XP_415401.2",0.723],["NP_001257645.1","XP_424816.3",0.699],["NP_001264934.1","NP_001006350.1",0.641],["NP_001264934.1","NP_989494.2",0.699],["NP_001264934.1","XP_424816.3",0.663],["NP_001264934.1","XP_415401.2",0.748],["NP_989494.2","NP_001006350.1",0.699],["NP_989494.2","XP_415401.2",0.638],["NP_989494.2","XP_424816.3",0.707],["XP_415401.2","XP_424816.3",0.756],["XP_415401.2","NP_001006350.1",0.726],["NP_001006350.1","XP_424816.3",0.713]],"all_go_terms":{"GO:0043312":1,"GO:0006890":1,"GO:0043320":1,"GO:0015031":2,"GO:0006891":1,"GO:0042144":1,"GO:0050775":1,"GO:0034197":1,"GO:0006903":1,"GO:0042147":1,"GO:1900483":1,"GO:1990668":1,"GO:0035493":1,"GO:0006888":1,"GO:0048280":1,"GO:0043308":1,"GO:1903595":1,"GO:0033160":1,"GO:0016485":1,"GO:0035556":1,"GO:0048538":1,"GO:0032436":1,"GO:0030900":1,"GO:0061053":1,"GO:0016080":1,"GO:0007220":1,"GO:0048167":1,"GO:0001921":1,"GO:0051402":1,"GO:0021795":1,"GO:0048854":1,"GO:0001947":1,"GO:0043524":1,"GO:0018991":1,"GO:0007219":1,"GO:0009791":1,"GO:0006979":1,"GO:0006486":1,"GO:0007175":1,"GO:0021987":1,"GO:2000059":1,"GO:0021904":1,"GO:0016337":1,"GO:0003407":1,"GO:0060075":1,"GO:2001234":1,"GO:0001708":1,"GO:0050771":1,"GO:1904797":1,"GO:0050820":1,"GO:0007286":1,"GO:0001764":1,"GO:0060070":1,"GO:0043406":1,"GO:0044671":1,"GO:0050852":1,"GO:0006914":1,"GO:0015813":1,"GO:0007420":1,"GO:0060999":1,"GO:0034205":1,"GO:0043393":1,"GO:0048705":1,"GO:0043065":1,"GO:0051444":1,"GO:0001568":1,"GO:0048666":1,"GO:0007613":1,"GO:0006974":1,"GO:0070588":1,"GO:0050673":1,"GO:0015871":1,"GO:0002244":1,"GO:0002286":1,"GO:0051563":1,"GO:0007507":1,"GO:0006839":1,"GO:0031149":1,"GO:0051966":1,"GO:0021870":1,"GO:0043011":1,"GO:0000186":1,"GO:0043589":1,"GO:0006509":1,"GO:0030326":1,"GO:0022008":1,"GO:0001756":1,"GO:0000045":1,"GO:2000049":1,"GO:0090297":1,"GO:0032933":1,"GO:1990046":1,"GO:1901585":1,"GO:0045541":1,"GO:0010918":1,"GO:0060355":1,"GO:0032623":1,"GO:0030433":1,"GO:0007007":1,"GO:1903905":1,"GO:0052547":1,"GO:0070584":1,"GO:0070528":1,"GO:0032226":1,"GO:1903044":1,"GO:0045861":1,"GO:0001302":1,"GO:1900210":1,"GO:0034141":1,"GO:0010876":1,"GO:0072249":1,"GO:0000001":1,"GO:0007588":1,"GO:0022617":1,"GO:0006895":1,"GO:0000042":1,"GO:0043001":1,"GO:0030148":1,"GO:0007266":1,"GO:0007249":1,"GO:0030497":1,"GO:0042761":1,"GO:0071529":1,"GO:0046726":1,"GO:0007254":1,"GO:0045070":1},"recipe_readded":[]}