{"hash":"330580849896570140","title":"p53-mediated DNA damage response and translation control","description":"The cluster centers on DNA damage sensing and p53-mediated signaling leading to cell cycle arrest and apoptosis, with accompanying transcriptional regulation. In addition, several terms highlight regulation of translation and ribosome biogenesis, suggesting a coordinated stress response that couples DNA damage signaling to protein synthesis control (e.g., UV/gamma radiation responses, p53 targets like p21). Overall, the data point to a cohesive module around p53-driven DNA damage response and translational regulation.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"members":[{"accession":"XP_036074851.1","go_terms":["GO:0042273","GO:0071480","GO:1902167","GO:0042256","GO:0006977","GO:0034644","GO:0045727","GO:1902164","GO:0006412","GO:1904803"]},{"accession":"XP_036079960.1","go_terms":["GO:0002181","GO:0046677"]},{"accession":"XP_036093798.1","go_terms":["GO:0002181"]},{"accession":"XP_015974490.1","go_terms":["GO:0006415","GO:0032543","GO:0000027"]},{"accession":"XP_015974816.1","go_terms":["GO:0015968","GO:0006415","GO:0006412","GO:0000027"]},{"accession":"XP_015978384.1","go_terms":[]},{"accession":"XP_016000590.1","go_terms":["GO:0042273","GO:0071480","GO:1902167","GO:0042256","GO:0006977","GO:0034644","GO:0045727","GO:1902164","GO:0006412","GO:1904803","GO:0032784","GO:0031564","GO:0006354","GO:0006353"]},{"accession":"XP_016006436.1","go_terms":["GO:1902164","GO:1902167","GO:0032784","GO:0006977","GO:1904803","GO:0042273","GO:0031564","GO:0071480","GO:0006354","GO:0006353","GO:0045727","GO:0006412"]},{"accession":"XP_016009728.1","go_terms":["GO:1903955","GO:0000463","GO:0000466","GO:0006412","GO:1903146"]},{"accession":"XP_016012082.1","go_terms":["GO:1901194","GO:0006412"]},{"accession":"XP_016021679.2","go_terms":["GO:1902164","GO:1902167","GO:0032784","GO:0006977","GO:1904803","GO:0042273","GO:0031564","GO:0071480","GO:0006354","GO:0006353","GO:0045727","GO:0006412"]}],"graph":[["XP_016012082.1","XP_016000590.1",0.609],["XP_016012082.1","XP_016006436.1",0.684],["XP_016012082.1","XP_016009728.1",0.843],["XP_016012082.1","XP_016021679.2",0.863],["XP_016012082.1","XP_036093798.1",0.713],["XP_016012082.1","XP_036079960.1",0.883],["XP_016012082.1","XP_036074851.1",0.757],["XP_016012082.1","XP_015974490.1",0.863],["XP_016012082.1","XP_015974816.1",0.899],["XP_016012082.1","XP_015978384.1",0.98],["XP_036079960.1","XP_016000590.1",0.909],["XP_036079960.1","XP_016006436.1",0.902],["XP_036079960.1","XP_016009728.1",0.936],["XP_036079960.1","XP_016021679.2",0.936],["XP_036079960.1","XP_036074851.1",0.885],["XP_036079960.1","XP_036093798.1",0.916],["XP_036079960.1","XP_015974490.1",0.947],["XP_036079960.1","XP_015974816.1",0.954],["XP_036079960.1","XP_015978384.1",0.971],["XP_015978384.1","XP_015974490.1",0.979],["XP_015978384.1","XP_015974816.1",0.976],["XP_015978384.1","XP_016000590.1",0.988],["XP_015978384.1","XP_016006436.1",0.988],["XP_015978384.1","XP_016009728.1",0.959],["XP_015978384.1","XP_016021679.2",0.976],["XP_015978384.1","XP_036074851.1",0.984],["XP_015978384.1","XP_036093798.1",0.966],["XP_036093798.1","XP_016000590.1",0.711],["XP_036093798.1","XP_016006436.1",0.601],["XP_036093798.1","XP_016009728.1",0.863],["XP_036093798.1","XP_016021679.2",0.887],["XP_036093798.1","XP_036074851.1",0.736],["XP_036093798.1","XP_015974490.1",0.856],["XP_036093798.1","XP_015974816.1",0.898],["XP_016009728.1","XP_016000590.1",0.8],["XP_016009728.1","XP_016006436.1",0.726],["XP_016009728.1","XP_016021679.2",0.907],["XP_016009728.1","XP_036074851.1",0.853],["XP_016009728.1","XP_015974490.1",0.906],["XP_016009728.1","XP_015974816.1",0.947],["XP_016000590.1","XP_016021679.2",0.934],["XP_016000590.1","XP_016006436.1",0.593],["XP_016000590.1","XP_036074851.1",0.746],["XP_016000590.1","XP_015974490.1",0.832],["XP_016000590.1","XP_015974816.1",0.903],["XP_016021679.2","XP_016006436.1",0.924],["XP_016021679.2","XP_036074851.1",0.902],["XP_016021679.2","XP_015974490.1",0.941],["XP_016021679.2","XP_015974816.1",0.959],["XP_015974816.1","XP_015974490.1",0.918],["XP_015974816.1","XP_016006436.1",0.921],["XP_015974816.1","XP_036074851.1",0.891],["XP_036074851.1","XP_016006436.1",0.696],["XP_036074851.1","XP_015974490.1",0.849],["XP_015974490.1","XP_016006436.1",0.858]],"all_go_terms":{"GO:0006977":4,"GO:1902164":4,"GO:0034644":2,"GO:1904803":4,"GO:0042273":4,"GO:0006412":7,"GO:1902167":4,"GO:0045727":4,"GO:0071480":4,"GO:0042256":2,"GO:0002181":2,"GO:0046677":1,"GO:0006415":2,"GO:0032543":1,"GO:0000027":2,"GO:0015968":1,"GO:0006353":3,"GO:0032784":3,"GO:0006354":3,"GO:0031564":3,"GO:0000463":1,"GO:0000466":1,"GO:1903955":1,"GO:1903146":1,"GO:1901194":1},"recipe_readded":[]}