{"hash":"2007238313771711812","title":"Retroviral Integration and Host Manipulation","description":"The top GO terms cluster around DNA integration, recombination, and RNA-templated DNA synthesis, with emphasis on proviral latency and viral entry into the host nucleus, plus suppression of host RNA silencing and host apoptosis pathways. This pattern points to retroviral (or similar mobile genetic element) genome integration and active host interaction/manipulation rather than housekeeping DNA replication alone. While some terms reference general symbiont-host interactions, the core signal is retroviral genome integration, replication steps, and strategies to counter host defenses. Confidence in this label is High.","confidence":"","size":29,"edges":307,"triangles":1660,"max_degree":26,"top_function":"DNA recombination","members":[{"accession":"XP_044163488.1","go_terms":["GO:0046718","GO:0006310","GO:0006278","GO:0075713","GO:0075732","GO:0015074","GO:0006260","GO:0039651","GO:1903704"]},{"accession":"XP_044166377.1","go_terms":[]},{"accession":"XP_044171839.1","go_terms":["GO:0046718","GO:0006310","GO:0006278","GO:0075713","GO:0075732","GO:0015074","GO:0006260","GO:0039651","GO:1903704"]},{"accession":"XP_044182463.1","go_terms":["GO:0046718","GO:0006310","GO:0006278","GO:0075713","GO:0075732","GO:0015074","GO:0006260","GO:0039651","GO:1903704","GO:0006313"]},{"accession":"XP_044183755.1","go_terms":["GO:0046718","GO:0006310","GO:0006278","GO:0075713","GO:0075732","GO:0015074","GO:0006260","GO:0039651","GO:1903704"]},{"accession":"XP_044165339.1","go_terms":[]},{"accession":"XP_044166453.1","go_terms":["GO:0009247","GO:0009405","GO:0097502","GO:0008654","GO:0007631","GO:0009413","GO:0010125","GO:0009414","GO:0072708","GO:0071793","GO:0009744","GO:0006490","GO:0005978","GO:0005985","GO:0010555","GO:0033577","GO:0006506","GO:0006006","GO:0019252"]},{"accession":"XP_044176249.1","go_terms":["GO:2000327","GO:0014912","GO:0003335","GO:2001153","GO:0045454","GO:0071375","GO:0043488","GO:0044179","GO:0006308","GO:0046856","GO:1900087","GO:0090502","GO:0006284","GO:0070301","GO:2000466","GO:0006915","GO:1903507","GO:0006310","GO:0080111","GO:0007568","GO:0071320","GO:0042493","GO:0006313"]},{"accession":"XP_044179061.1","go_terms":["GO:0009247","GO:0009405","GO:0097502","GO:0008654","GO:0007631","GO:0009413","GO:0010125","GO:0009414","GO:0072708","GO:0071793","GO:0009744","GO:0006490","GO:0005978","GO:0005985","GO:0010555","GO:0033577","GO:0006506","GO:0006006","GO:0019252"]},{"accession":"XP_044179643.1","go_terms":["GO:2000327","GO:0014912","GO:0003335","GO:2001153","GO:0045454","GO:0071375","GO:0043488","GO:0044179","GO:0006308","GO:0046856","GO:1900087","GO:0090502","GO:0006284","GO:0070301","GO:2000466","GO:0006915","GO:1903507","GO:0006310","GO:0080111","GO:0007568","GO:0071320","GO:0042493"]},{"accession":"XP_029191565.2","go_terms":["GO:0009312","GO:0018279"]},{"accession":"XP_029205200.2","go_terms":["GO:0005975","GO:0006487"]},{"accession":"XP_029205201.2","go_terms":["GO:0005975","GO:0006487"]},{"accession":"XP_029208303.2","go_terms":["GO:0046718","GO:0006310","GO:0006278","GO:0075713","GO:0075732","GO:0015074","GO:0006260","GO:0039651","GO:1903704","GO:0006289","GO:0090305","GO:0006261","GO:0009432","GO:0039657"]},{"accession":"XP_044164364.1","go_terms":["GO:0075015","GO:0042248","GO:0010493","GO:0018258","GO:0080147","GO:0010405","GO:0030311","GO:0001744","GO:0007299","GO:0048354"]},{"accession":"XP_044164793.1","go_terms":["GO:0046718","GO:0006310","GO:0006278","GO:0075713","GO:0075732","GO:0015074","GO:0006260","GO:0039651","GO:1903704","GO:0006289","GO:0090305","GO:0006261","GO:0009432","GO:0039657"]},{"accession":"XP_044167002.1","go_terms":["GO:0015074"]},{"accession":"XP_044167525.1","go_terms":[]},{"accession":"XP_044168447.1","go_terms":["GO:0046718","GO:0006310","GO:0006278","GO:0075713","GO:0075732","GO:0015074","GO:0006260","GO:0039651","GO:1903704","GO:2000327","GO:0014912","GO:0003335","GO:2001153","GO:0045454","GO:0071375","GO:0043488","GO:0044179","GO:0006308","GO:0046856","GO:1900087","GO:0090502","GO:0006284","GO:0070301","GO:2000466","GO:0006915","GO:1903507","GO:0080111","GO:0007568","GO:0071320","GO:0042493"]},{"accession":"XP_044171184.1","go_terms":[]},{"accession":"XP_044172001.1","go_terms":["GO:0009247","GO:0009405","GO:0097502","GO:0008654","GO:0007631","GO:0009413","GO:0010125","GO:0009414","GO:0072708","GO:0071793","GO:0009744","GO:0006490","GO:0005978","GO:0005985","GO:0010555","GO:0033577","GO:0006506","GO:0006006","GO:0019252"]},{"accession":"XP_044172257.1","go_terms":[]},{"accession":"XP_044172599.1","go_terms":[]},{"accession":"XP_044174294.1","go_terms":["GO:0046718","GO:0006310","GO:0006278","GO:0075713","GO:0075732","GO:0015074","GO:0006260","GO:0039651","GO:1903704"]},{"accession":"XP_044176761.1","go_terms":["GO:0046718","GO:0006310","GO:0006278","GO:0075713","GO:0075732","GO:0015074","GO:0006260","GO:0039651","GO:1903704"]},{"accession":"XP_029189782.1","go_terms":["GO:0009312","GO:0018279"]},{"accession":"XP_029194452.2","go_terms":["GO:0032922","GO:2000323","GO:0071000","GO:2000850","GO:0019915","GO:0009650","GO:0045475","GO:1902448","GO:0009638","GO:0042332","GO:0050980","GO:0009584","GO:0050958","GO:0048574","GO:0009588","GO:0033762","GO:1902347","GO:0006975","GO:0000719","GO:0042754","GO:0018298","GO:0009785","GO:0009646","GO:0010117","GO:0010343","GO:1901371","GO:1901332","GO:0010617","GO:0010075","GO:1901672","GO:0010244","GO:0045187","GO:2000001","GO:0043153","GO:0010118"]},{"accession":"XP_029210310.2","go_terms":["GO:0006049","GO:0006486","GO:0035010","GO:0035284"]},{"accession":"XP_044166311.1","go_terms":["GO:0015074"]}],"graph":[["XP_044166311.1","XP_029205200.2",0.864],["XP_044166311.1","XP_029205201.2",0.894],["XP_044166311.1","XP_029208303.2",0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