[{"hash":"38351973548842579","title":"Ribosome biogenesis and rRNA maturation","description":"Go terms are centered on ribosome biogenesis and rRNA maturation (SSU/LSU rRNA processing, maturation from tricistronic rRNA, ribosomal large subunit biogenesis). A few secondary terms (mRNA splicing, ubiquitination, embryonic development) appear, but the dominant signal is proteins involved in ribosome assembly and rRNA processing.","confidence":"High","size":29,"edges":2,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0000466","count":6},{"id":"GO:0000462","count":6},{"id":"GO:0042273","count":6},{"id":"GO:0000463","count":6}]},{"hash":"1975607582919043021","title":"Golgi trafficking and glycosylation","description":"The top GO terms cluster around Golgi-related processes: ER-to-Golgi vesicle transport, Golgi localization, and Golgi-to-plasma membrane transport, along with protein glycosylation and GPI-anchor biosynthesis. A couple terms about neural development appear but do not undermine the central theme of Golgi trafficking and protein modification.","confidence":"Medium","size":29,"edges":18,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0021631","count":2}]},{"hash":"8697371107028354","title":"Heart and neural development","description":"The cluster is enriched for developmental processes, especially heart and pulmonary myocardium development and organ induction, with strong signals for neural development such as neuron migration, motor neuron axon guidance, and midbrain development, suggesting proteins that coordinate cardiovascular and nervous system formation during embryogenesis.","confidence":"High","size":29,"edges":12,"triangles":0,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007275","count":13},{"id":"GO:0003350","count":12},{"id":"GO:0007507","count":12},{"id":"GO:0001764","count":12},{"id":"GO:0048701","count":12}]},{"hash":"434092721840425730","title":"Redox Homeostasis and Notch Regulation","description":"The prominent GO terms point to oxidative stress management (oxidation-reduction, detoxification, redox homeostasis) together with regulatory signaling and transcription (negative regulation of Notch signaling, DNA-templated transcription). Some members also touch on receptor internalization and lipopolysaccharide response, suggesting a broader stress-response/signaling module. Taken together, the cluster appears to capture proteins involved in maintaining redox balance while modulating signaling and transcription.","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0098869","count":3},{"id":"GO:0045746","count":3},{"id":"GO:0045454","count":3},{"id":"GO:0006351","count":3}]},{"hash":"368261001682588816","title":"Neuronal sensory signaling and GPCR trafficking","description":"The cluster's top GO terms cluster around nervous-system signaling: sensory perception of pain, dopaminergic synaptic transmission, GPCR internalization, and responses to temperature and prostaglandin stimuli. This suggests a module of proteins involved in neural signal transduction and sensory processing, with GPCR trafficking as a key feature. Some terms like heart development and macrophage chemotaxis may reflect shared signaling components rather than a strict single-pathway function.","confidence":"Medium","size":29,"edges":324,"triangles":1905,"max_degree":26,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":27},{"id":"GO:0071502","count":26},{"id":"GO:0042391","count":26},{"id":"GO:0002024","count":26},{"id":"GO:0071380","count":25}]},{"hash":"954152390716086072","title":"Pain Perception and Drug-Response Neurotransmission","description":"The terms cluster around sensory perception and pain (including regulation), learning-related processes, and responses to opioids and psychostimulants (morphine, amphetamine), with modulation of glutamatergic transmission and sensorimotor gating (prepulse inhibition). This indicates a neural circuitry theme linking pain perception, sensory processing, and drug-induced behavioral responses, hence a concise label focusing on pain perception and drug-response neurotransmission.","confidence":"High","size":29,"edges":93,"triangles":48,"max_degree":15,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":27},{"id":"GO:0002024","count":27},{"id":"GO:0019233","count":27},{"id":"GO:0051930","count":25},{"id":"GO:0051967","count":25}]},{"hash":"1963467741723200277","title":"Complement-Driven Immune Activation and Leukocyte Adhesion","description":"The top GO terms center on innate immune functions: complement activation (lectin pathway), Fc-gamma receptor signaling, leukocyte tethering/rolling, phagocytosis recognition, and regulation of adhesion molecules, along with platelet activation, all pointing to immune signaling and leukocyte interactions. Some development terms appear as noise, but the dominant theme is immune activation and leukocyte adhesion.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0001867","count":12},{"id":"GO:0007413","count":11},{"id":"GO:0072218","count":11},{"id":"GO:0072237","count":11},{"id":"GO:0010572","count":11}]},{"hash":"611173161463485161","title":"Unknown","description":"The top GO terms span cell division, photosynthesis, responses to exogenous dsRNA, cadmium stress, and various regulatory and obsolete processes, indicating a broad, heterogeneous set of functions rather than a single cohesive pathway. With 29 proteins and no reported edges or triangles, this cluster appears to be a mix of housekeeping and stress-related proteins rather than a defined functional module, making it hard to assign a concise, representative label.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0051301","count":26},{"id":"GO:0071360","count":25},{"id":"GO:1903646","count":25},{"id":"GO:0051348","count":25},{"id":"GO:0031400","count":25}]},{"hash":"1652619158535931493","title":"Neuropeptide signaling and cardiovascular regulation","description":"The cluster is dominated by terms like neuropeptide signaling (GO:0007218), regulation of vasopressin-mediated blood pressure (GO:0001992), and renin secretion into the bloodstream (GO:1900135), plus cardiac vascular smooth muscle differentiation (GO:2000724) and dopamine uptake regulation. This points to neuroendocrine control of vascular function and blood pressure, with supporting inflammatory signaling (chemokine and IL-1\u03b2 regulation) as potential cross-talk within the cluster. ","confidence":"Medium","size":29,"edges":128,"triangles":79,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":24},{"id":"GO:0032651","count":24},{"id":"GO:0007218","count":24},{"id":"GO:2000724","count":24},{"id":"GO:0090075","count":24}]},{"hash":"995542024121257438","title":"Unknown","description":"The top GO terms cover a mix of developmental signaling (Notch regulation, multicellular development, neural tube closure), innate immune responses, and basic cellular processes (ER-Golgi transport, microtubule severing, protein oligomerization) with no clear shared function across all 29 proteins. Because there isn\u2019t a cohesive functional theme linking the cluster, a single representative label isn\u2019t reliably assignable.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045746","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0007275","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0051013","count":2}]},{"hash":"1766971692042734604","title":"Neuroendocrine Thermoregulation and Blood Pressure Signaling","description":"This cluster centers on neuroendocrine and neural signaling linked to temperature response and thermogenesis, with components connected to pain perception and cardiovascular control (vasopressin regulation, dopamine uptake, smooth muscle relaxation, and blood pressure regulation).","confidence":"Medium","size":29,"edges":53,"triangles":9,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":28},{"id":"GO:0002024","count":28},{"id":"GO:0019233","count":28},{"id":"GO:0043950","count":27},{"id":"GO:0032651","count":27}]},{"hash":"580379268954412517","title":"Ribosome biogenesis and rRNA processing","description":"The strongest, cohesive signals come from GO terms tied to ribosome assembly and rRNA maturation: ribosomal small subunit export from the nucleus and endonucleolytic ITS1 cleavage separating rRNA components. While other terms point to stress or immune responses, the core pattern across these proteins consistently maps to ribosome biogenesis and rRNA processing, justifying this label as a concise representation of the cluster. ","confidence":"Medium","size":29,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000056","count":2},{"id":"GO:0000447","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0006508","count":2}]},{"hash":"1258932450540992647","title":"Cardiometabolic signaling and hemostasis","description":"The cluster\u2019s top terms center on cardiovascular and hemostatic functions (platelet activation, blood coagulation, regulation of blood pressure) alongside energy and signaling pathways (electron transport chain, GPCR-cAMP signaling, Rho signaling). This suggests proteins involved in coordinating metabolism with vascular and coagulation responses, justifying a label that reflects cardiometabolic signaling linked to hemostasis.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":16},{"id":"GO:0002024","count":16},{"id":"GO:0019233","count":16},{"id":"GO:0045777","count":16},{"id":"GO:0022900","count":16}]},{"hash":"2007238313771711812","title":"Retroviral Integration and Host Manipulation","description":"The top GO terms cluster around DNA integration, recombination, and RNA-templated DNA synthesis, with emphasis on proviral latency and viral entry into the host nucleus, plus suppression of host RNA silencing and host apoptosis pathways. This pattern points to retroviral (or similar mobile genetic element) genome integration and active host interaction/manipulation rather than housekeeping DNA replication alone. While some terms reference general symbiont-host interactions, the core signal is retroviral genome integration, replication steps, and strategies to counter host defenses. Confidence in this label is High.","confidence":"","size":29,"edges":307,"triangles":1660,"max_degree":26,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":11},{"id":"GO:0006310","count":11},{"id":"GO:0006278","count":9},{"id":"GO:1903704","count":9},{"id":"GO:0075713","count":9}]},{"hash":"2211194472813436929","title":"Ubiquitin-Driven Innate Immune Signaling","description":"The cluster is dominated by GO terms for ubiquitin-related processes (ubiquitin-dependent protein catabolic process; K63- and K6-linked ubiquitination; autoubiquitination) and innate immune functions (innate immune response, defense response to virus) with related NF-kappaB regulation, suggesting a cohesive role in ubiquitin-mediated antiviral signaling. Some DNA-related terms appear, but the central theme remains ubiquitin signaling in immunity.","confidence":"Medium","size":29,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0045087","count":9},{"id":"GO:0051092","count":8},{"id":"GO:0070534","count":7},{"id":"GO:0051865","count":7}]},{"hash":"810440378673795489","title":"Neuropeptide GPCR signaling and blood pressure regulation","description":"This cluster is dominated by GO terms linking neuropeptide signaling and GPCR pathways to cardiovascular control, including adenylate cyclase-activating GPCR signaling, vasopressin-regulated blood pressure, neuropeptide signaling, and dopamine uptake regulation, suggesting a cohesive theme around neural signaling modulating vascular tone. A secondary term for energy metabolism (electron transport chain) is present but does not define the core function.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":29},{"id":"GO:0045777","count":29},{"id":"GO:0022900","count":29},{"id":"GO:0043950","count":28},{"id":"GO:0032651","count":28}]},{"hash":"1748532417599521303","title":"Inflammation-driven vascular response and coagulation","description":"The cluster is dominated by GO terms related to immune activation and vascular dynamics, including inflammatory response, response to lipopolysaccharide, GPCR signaling, and positive regulation of blood pressure and vasoconstriction, plus coagulation. These collectively point to an endotoxin-related inflammatory vascular response. A minority term about the electron transport chain is a less specific metabolic note, but it does not override the main inflammatory-vascular theme.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":27},{"id":"GO:0006954","count":27},{"id":"GO:0045777","count":27},{"id":"GO:0045907","count":27},{"id":"GO:0022900","count":27}]},{"hash":"382835080046787062","title":"ECM Remodeling and Angiogenesis Regulation","description":"The top GO terms point to extracellular matrix organization and cell adhesion (cell adhesion, collagen fibril organization), together with controls on blood vessel growth (negative regulation of angiogenesis) and morphogenesis signals (hepatocyte growth factor receptor signaling, branching morphogenesis). The presence of responses to mechanical stimulus and macrophage chemotaxis suggests a tissue-remodeling/immune interface, while complement activation hints at inflammatory context. Taken together, the cluster appears to group proteins involved in ECM remodeling, cell adhesion, and regulation of angiogenesis and morphogenesis rather than a single enzymatic pathway.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":4},{"id":"GO:0016525","count":4},{"id":"GO:0071260","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0001867","count":3}]},{"hash":"1032368662311107785","title":"Immune signaling and lymphocyte regulation","description":"This cluster is dominated by GO terms related to immune function: inflammatory response, negative regulation of IL-2 production, B cell homeostasis, and T follicular helper cell differentiation, suggesting a core theme of immune signaling and lymphocyte regulation. Some non-immune terms (eye and nervous system development) appear as outliers and may reflect broad or cross-species annotations, but the immune-related terms are the strongest pattern. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048632","count":2},{"id":"GO:0021517","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0043010","count":2},{"id":"GO:0001782","count":2}]},{"hash":"1334348500145267585","title":"Excitatory Synapse Signaling and Calcium Handling","description":"The terms point to neuronal excitatory signaling, especially glutamatergic transmission, with calcium ion transport and postsynaptic potential generation, receptor clustering, and intracellular signaling. The presence of cerebellar granule cell differentiation and memory-related terms reinforces a neural context focused on excitatory synapses and calcium-dependent signaling, though some terms imply broader neurophysiological modulation.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":5},{"id":"GO:0006816","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0043113","count":4},{"id":"GO:0098907","count":4}]},{"hash":"821277870004851047","title":"Unknown","description":"The top terms cover insect development (eye/antenna), transcription regulation, snoRNP assembly, DNA transposition, multicellular development, MHC class I antigen processing, and renin-angiotensin\u2013related blood pressure regulation. This broad and scattered mix lacks a coherent shared function or pathway, and with no edges connecting proteins, it seems a heterogeneous collection rather than a single functional cluster.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045316","count":2},{"id":"GO:0007469","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000492","count":1}]},{"hash":"2249164715317337422","title":"Proviral integration and retrotransposon activity","description":"The GO terms cluster around DNA integration, RNA-templated DNA synthesis, retrotransposition, and proviral latency, with supporting terms for DNA recombination and host interactions, indicating retroelement or viral DNA integrating into genomes and establishing latency, rather than a single, cohesive cellular pathway.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0015074","count":10},{"id":"GO:0006260","count":6},{"id":"GO:0006278","count":5},{"id":"GO:1903704","count":5},{"id":"GO:0075713","count":5}]},{"hash":"272762451386233446","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0002250","count":2},{"id":"GO:0010587","count":2},{"id":"GO:0030260","count":2},{"id":"GO:0019076","count":2}]},{"hash":"1120352776670034199","title":"Unknown","description":"The terms in this cluster are highly heterogeneous, spanning host-symbiont interactions, animal behavior, neuromuscular control, transcription regulation, plant development (seed growth, chlorophyll biosynthesis), and telomere/genome maintenance. With no edges or connectivity among proteins (Edges 0, Triangles 0, Max Degree 0), there isn\u2019t a single cohesive biological theme tying the GO terms together, so a clear, specific functional label isn\u2019t supported.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046597","count":2},{"id":"GO:0007628","count":2},{"id":"GO:0050884","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0080113","count":2}]},{"hash":"504914012930575370","title":"Neuronal ion transport and signaling","description":"This cluster shows a strong emphasis on ion transport across membranes (sodium, potassium, calcium) and neurotransmission (GABA signaling, excitatory postsynaptic potential), coupled with behavior-related terms such as startle response, locomotory behavior, and circadian sleep regulation. The combination suggests a cohesive theme of neuronal excitability and behavioral output, with possible minor outliers like acrosome reaction. ","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":23},{"id":"GO:0001964","count":22},{"id":"GO:0045188","count":22},{"id":"GO:0098703","count":22},{"id":"GO:0060079","count":21}]},{"hash":"47261294119360026","title":"Neural cell adhesion and paranode axon organization","description":"The top GO terms center on cell adhesion (heterophilic adhesion, general adhesion) and on specialized axonal domains (paranode and juxtaparanode localization and assembly) as well as synapse assembly, pointing to proteins that mediate neural cell contacts and the organization of axon\u2013glial junctions. The presence of terms for paranodal junctions and axon-region localization suggests a cohesive theme around neural adhesion and paranode/axon domain architecture, with supportive signals for synapse formation. Therefore the label captures the dominant function of this cluster.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":6},{"id":"GO:0002042","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0007155","count":5},{"id":"GO:0002175","count":5}]},{"hash":"93953682687094555","title":"Cardiac mechanotransduction and apoptosis signaling","description":"Terms cluster around mechanical stimulus response and heart-specific signaling (response to muscle stretch; cellular response to mechanical stimulus; regulation of SA node cell action potential; SA node cell to atrial cardiac muscle cell communication), suggesting a cardiac mechanotransduction theme. The presence of necroptotic and apoptotic processes (ripoptosome assembly; hepatocyte apoptotic process) points to stress signaling that can occur in cardiac tissue. Some terms are more general or immune-related and less connected to the core theme, but the dominant pattern supports a cardiac mechanotransduction with stress signaling view.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":4},{"id":"GO:0035994","count":3},{"id":"GO:0072660","count":3},{"id":"GO:0098907","count":3},{"id":"GO:0071260","count":3}]},{"hash":"60341746271049426","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0007399","count":2},{"id":"GO:0000378","count":2},{"id":"GO:0008306","count":2},{"id":"GO:1902775","count":2}]},{"hash":"1223211835568527681","title":"Retroviral DNA synthesis and integration","description":"The top GO terms highlight RNA-templated DNA biosynthesis (reverse transcription), DNA replication and DNA integration, along with the establishment of integrated proviral latency and DNA recombination. This pattern points to processes involved in the retroviral genome life cycle and provirus maintenance, rather than general cellular signaling. Some terms about viral entry into the host nucleus and host\u2013symbiont interactions further support a focus on viral/host genome integration events.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006278","count":4},{"id":"GO:1903704","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0006310","count":4}]},{"hash":"1894334801826811383","title":"Tissue-specific development and differentiation","description":"The Top GO terms include forebrain development, osteoblast differentiation, multicellular organism development, and prostate glandular epithelium differentiation, indicating a cluster enriched for tissue-specific developmental programs. Additional terms like DNA-templated transcription, RNA processing, ubiquitin-dependent proteolysis, and ER-Golgi transport reflect general cellular machinery supporting development. Overall, the proteins seem linked to broad developmental differentiation across tissues rather than a single pathway, supporting this label with moderate confidence.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0031146","count":4},{"id":"GO:0007275","count":4}]},{"hash":"2121638193660590587","title":"Ubiquitin-Proteasome and Mitophagy Stress Response","description":"The cluster centers on ubiquitin-dependent protein quality control (autoubiquitination, ERAD), protein aggregation management (aggresome assembly), and mitochondrial quality control (mitophagy, regulation of mitochondrial fusion). It also includes stress-related processes (cellular response to toxic substances) and inflammatory signaling (TNF-mediated signaling), suggesting an integrated module for protein and mitochondrial quality control under stress. This combination best fits a ubiquitin-proteasome/mitophagy stress-response theme.","confidence":"High","size":28,"edges":113,"triangles":238,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1903265","count":12},{"id":"GO:0051865","count":12},{"id":"GO:0030433","count":10},{"id":"GO:0010636","count":8},{"id":"GO:0000423","count":8}]},{"hash":"292544933551185751","title":"Developmental signaling with vascular and immune remodeling","description":"The terms point to developmental signaling (midbrain development, Wnt signaling, growth) together with extracellular remodeling (angiogenesis, plasminogen activation, fibrinolysis) and immune/coagulation pathways (complement activation via lectin pathway, defense against Gram-positive bacteria, LPS response). This combination suggests a module where developmental cues intersect with vascular remodeling and innate immune/coagulation activity, justifying a label that reflects this integrated theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0031639","count":6},{"id":"GO:0035264","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0001867","count":5}]},{"hash":"162130958157517365","title":"Mitochondrial Translation and Complex IV Assembly","description":"GO term pattern centers on mitochondrial processes: translation, import into the mitochondrial matrix, and assembly of the mitochondrial respiratory chain complex IV, with accompanying cofactor biosynthesis (lipoylation, Mo-cofactor, PQQ) tied to mitochondrial enzymes, suggesting a mitochondria-focused functional cluster.","confidence":"High","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006777","count":2},{"id":"GO:0030150","count":2},{"id":"GO:0033617","count":2},{"id":"GO:0018339","count":1}]},{"hash":"322856769570056833","title":"Unknown","description":"The Top Terms cover a wide range of processes\u2014from vesicle trafficking and secretion (pinocytosis regulation, SNARE regulation, vasopressin secretion) to multiple signaling pathways (Wnt, NOD1), along with cytoskeletal/mitotic roles (spindle assembly) and various stress or physiological responses (cold response, muscle stretch, electrical coupling). The lack of a coherent, single functional theme among these terms, combined with 0 edges and mixed single-term representations, suggests these proteins do not share a singular, well-defined function cluster. Therefore, Unknown with None confidence.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048549","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0051225","count":1},{"id":"GO:0009409","count":1},{"id":"GO:0030103","count":1}]},{"hash":"1993254712342748921","title":"Developmental Gene Expression and Differentiation","description":"This cluster centers on transcriptional regulation and broad developmental processes across tissues: transcription by RNA polymerase II, circadian regulation of gene expression, and various development terms (bronchiole, mesenchyme, oculomotor nerve, subpallium neuron fate, pigmentation). The combination points to proteins involved in regulating when and where genes are expressed during development, rather than a single pathway.","confidence":"Medium","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":25},{"id":"GO:0043433","count":24},{"id":"GO:2001038","count":24},{"id":"GO:0032922","count":24},{"id":"GO:0048712","count":24}]},{"hash":"870553494463803778","title":"Multitissue development and neural signaling","description":"The top GO terms point to eye/visual system development (retina formation, visual perception) and heart development, plus neural processes (regulation of synaptic vesicle endocytosis) and skin development, suggesting proteins involved in broad developmental programs across tissues with a neural component.","confidence":"Medium","size":28,"edges":4,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1900242","count":14},{"id":"GO:0097274","count":14},{"id":"GO:0010842","count":14},{"id":"GO:0038095","count":9},{"id":"GO:0032516","count":9}]},{"hash":"1295712684356675008","title":"Innate Immune Signaling and ECM Remodeling","description":"The dominant GO terms point to innate immune pathways (TLR4/8 signaling, NOD2, interferon production) with concurrent extracellular matrix remodeling signals (collagen fibril organization, inhibition of angiogenesis), suggesting a cohesive theme of immune activation linked to ECM dynamics.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030199","count":8},{"id":"GO:0016525","count":7},{"id":"GO:0006469","count":6},{"id":"GO:0051965","count":6},{"id":"GO:0019800","count":5}]},{"hash":"789580363094856535","title":"Retroviral DNA integration and transposition","description":"The GO terms cluster around DNA integration, proviral latency, and viral entry into the host nucleus, complemented by reverse transcription and DNA-level processes like replication, recombination, and transposition. Together these point to retroviral or transposon-like activity driving genome integration and propagation, with some host-interaction hints (symbiont-related apoptosis) that fit within viral-host dynamics. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":10},{"id":"GO:0075713","count":6},{"id":"GO:0075732","count":5},{"id":"GO:0039651","count":5},{"id":"GO:0046718","count":5}]},{"hash":"831210724803835813","title":"Ciliary trafficking and endocytic recycling","description":"The top GO terms point to intracellular trafficking processes linked to cilia, including intraciliary transport for cilium assembly and endocytic recycling to the membrane. While some terms are broad or obsolete, the strongest cohesive signal is a cluster of proteins involved in ciliary transport and membrane recycling, with occasional ties to growth-related pathways. This label is a best-fit, with Medium confidence.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001137","count":2},{"id":"GO:0007049","count":2},{"id":"GO:2000009","count":2},{"id":"GO:0031532","count":2},{"id":"GO:2001172","count":1}]},{"hash":"1907452793135615658","title":"Unknown","description":"The Top Terms are diverse, spanning neural development, innate immune response, DNA transposition, protein degradation, synaptic transport, spermatid development, cell cycle, microtubule movement, and dsRNA response. The absence of a cohesive shared function and the lack of edges suggest these proteins do not converge on a single biological theme, so a specific, representative label isn\u2019t supported.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0006313","count":3},{"id":"GO:0033160","count":2},{"id":"GO:0042787","count":2}]},{"hash":"2291177784502715161","title":"Developmental Signaling and Cell Cycle","description":"The cluster is dominated by signaling-related terms (Wnt signaling, positive regulation of GTPase activity, intracellular signal transduction) and development-related terms (cerebral cortex development, multicellular organism development, male gonad development) along with proliferation and mitotic cohesion terms, pointing to a theme of developmental signaling coupled with cell cycle/proliferation control. Some terms (rRNA maturation) are peripheral outliers, but the core theme fits developmental signaling and growth regulation.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0016055","count":4},{"id":"GO:0035556","count":3},{"id":"GO:0021987","count":3},{"id":"GO:0007275","count":3}]},{"hash":"483676449051648383","title":"GABAergic Neuronal Signaling and Adhesion","description":"The cluster is dominated by GO terms for neuron cell-cell adhesion, GABAergic synaptic transmission, and sensory perception of sound, with additional neural development cues such as dopaminergic neuron axon guidance and cell- junction organization. While a few heart-related terms appear (mitral valve formation, conduction-related adhesion), the central theme centers on neural connectivity and neurotransmission, making this a neural signaling/adhesion cluster.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007158","count":4},{"id":"GO:0051932","count":4},{"id":"GO:0007605","count":4},{"id":"GO:1903263","count":3},{"id":"GO:0086073","count":3}]},{"hash":"988753526584684865","title":"Mitotic Cytokinesis and Vesicle Trafficking","description":"The top GO terms cluster strongly around the mitotic cell cycle, cell division, and mitotic cytokinesis, indicating a core theme of mitosis. The inclusion of intralumenal vesicle formation suggests associated vesicle trafficking that can participate in cytokinesis, reinforcing a combined role in cell division and membrane dynamics. Although some terms are broader or historical, the dominant signal points to mitotic machinery and cytokinesis with related trafficking processes.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0051301","count":3},{"id":"GO:2001162","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0000920","count":2}]},{"hash":"1891138979418503667","title":"Neuropeptide signaling with immune and cardiovascular regulation","description":"These proteins are enriched for neuropeptide signaling and downstream effects on cardiovascular and immune processes. The terms include neuropeptide signaling, vasopressin- and renin-related regulation of blood pressure, dopamine uptake in synapses, and regulation of IL-1 beta and chemokine production, suggesting a neuroendocrine axis coordinating vascular, renal, and immune responses.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":27},{"id":"GO:0032651","count":27},{"id":"GO:0007218","count":27},{"id":"GO:2000724","count":27},{"id":"GO:0090075","count":27}]},{"hash":"1949755236516437494","title":"Unknown","description":"The GO terms are broad and do not converge on a single function; they include proteolysis, lens fiber differentiation, DNA integration, defense against Gram-positive bacteria, mitotic and spindle-associated processes, dendrite development, meiotic regulation, and TORC1 signaling. Because there isn't a coherent shared theme across the cluster's annotations, a simple, representative label cannot be assigned.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:0070306","count":3},{"id":"GO:0015074","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0007064","count":2}]},{"hash":"234837814960316279","title":"Neural Development and Transcription Regulation","description":"The cluster prominently features terms related to transcription regulation by RNA polymerase II (both positive and negative) and neural development processes such as midbrain development and trigeminal ganglion development, suggesting proteins involved in neural development with transcriptional control. Some coagulation and biomineral development terms appear, which may reflect multifunctionality or annotation noise, but the core signal centers on neural development and transcriptional regulation.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0001867","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0044130","count":4},{"id":"GO:0030901","count":4}]},{"hash":"2109940507619661858","title":"Touch signaling and synaptic plasticity","description":"The cluster is dominated by GO terms related to touch perception, ionotropic glutamate receptor signaling, and long-term synaptic potentiation/depression, pointing to neuronal signaling and plasticity; startle response and social behavior terms further support neural circuit context, despite a stray cell wall term. ","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031623","count":7},{"id":"GO:0097011","count":6},{"id":"GO:0050975","count":6},{"id":"GO:0060292","count":6},{"id":"GO:1900273","count":6}]},{"hash":"1074456297585891145","title":"Unknown","description":"The top GO terms span multiple, seemingly unrelated biological areas: miRNA-mediated gene silencing, actin filament assembly, kinetochore regulation, error-prone translesion synthesis, protein desumoylation and deneddylation, and placental development layers, along with erythrocyte differentiation and endoreduplication regulation. There isn\u2019t a single coherent function or theme tying all terms together, making a concise, representative cluster name difficult.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035278","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0090234","count":2},{"id":"GO:1904333","count":2},{"id":"GO:0016926","count":2}]},{"hash":"1213357017226549139","title":"Inflammation and Pain Signaling with Vascular Response","description":"The top GO terms indicate a cohesive theme around innate immune and inflammatory processes (immune response, inflammatory response, LPS response, blood coagulation, vasoconstriction, calcium release), coupled with nociception (sensory perception of pain) and thermoregulatory signals (cellular response to temperature stimulus, diet-induced thermogenesis). Bone remodeling and metabolic aspects may reflect inflammation-linked remodeling. Together, these terms point to a cluster coordinating immune activation with pain signaling and vascular/coagulation responses, possibly modulated by metabolic changes during inflammation.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0071502","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0046849","count":5},{"id":"GO:0006955","count":5}]},{"hash":"1944745132565701855","title":"Neural crest migration and axon guidance","description":"The top GO terms cluster around neural development, especially neural crest cell migration, ganglion formation (trigeminal, sympathetic), and axon guidance (including commissural and retina-related pathways), with a minor role for protein ubiquitination as a regulatory mechanism.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061551","count":5},{"id":"GO:0048846","count":5},{"id":"GO:0016567","count":4},{"id":"GO:1902378","count":4},{"id":"GO:0036486","count":4}]},{"hash":"1045448820041403462","title":"Innate Immune Signaling and Adhesion","description":"The top GO terms emphasize innate immune response and defense against virus, along with signaling regulation (Rho, PI3K) and cell adhesion, suggesting a core function in immune signaling and cell\u2013cell interactions. While some developmental terms (kidney development, axonal fasciculation, dendritic spine regulation) appear, the strongest and most cohesive theme across this cluster relates to immune response and signaling pathways that modulate cell communication and adhesion. Therefore, a label focused on innate immunity and related signaling best captures the main theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0001822","count":3},{"id":"GO:0007413","count":3},{"id":"GO:0061000","count":3},{"id":"GO:0035023","count":3}]},{"hash":"381364540225687274","title":"Cardiac and vascular muscle regulation","description":"The cluster is dominated by GO terms tied to cardiac muscle contraction (GO:0060048) and regulation of heart contraction (GO:0060452), as well as relaxation of vascular smooth muscle (GO:0060087) and negative regulation of canonical Wnt signaling (GO:0035414), suggesting a core theme of cardiovascular muscle function and its signaling regulation. Additional terms like GPCR desensitization (GO:0002029) and chondrocyte development-related processes (GO:0061181, GO:0003413) may reflect broader signaling context or shared developmental pathways, but the strongest signal centers on heart and vascular muscle regulation. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035414","count":3},{"id":"GO:0003108","count":2},{"id":"GO:0060087","count":2},{"id":"GO:0060452","count":2},{"id":"GO:0002029","count":2}]},{"hash":"1739704765842047783","title":"DNA transposition and integration proteins","description":"The top GO terms are dominated by DNA transposition and DNA integration, suggesting a core function related to mobile DNA (transposase/integrase activity) in this cluster. The other terms present are diverse (endothelial barrier, glial growth, development, transport), likely secondary annotations or incidental associations, so the main theme remains DNA mobility. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0015074","count":2},{"id":"GO:0090557","count":2},{"id":"GO:0042066","count":1},{"id":"GO:0021794","count":1}]},{"hash":"739408834385336322","title":"Embryonic Development and Morphogenesis","description":"Top GO terms point to broad developmental and morphogenetic processes across tissues (heart cushion formation via EMT, left-right patterning, cartilage morphogenesis, CNS development, placenta-associated differentiation, pancreatic cell development, endocrine system development). The spliceosome-related term and the RNA Pol II regulatory region term likely reflect general gene expression regulation during development rather than a single pathway. Overall, the cluster seems to capture embryonic development and tissue formation rather than a specific molecular function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0000398","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0060972","count":5}]},{"hash":"177250534213173481","title":"Viral genome integration and latency","description":"The top GO terms cluster around steps in viral lifecycles that involve integrating viral DNA into the host genome, establishing proviral latency, and accessing the host nucleus (e.g., DNA integration, proviral latency, viral penetration into host nucleus, RNA-templated DNA biosynthesis). Additional related terms (DNA replication, recombination, transposition) align with genome integration and propagation of viral or transposable elements, and negative regulation of siRNA processing can reflect viral strategies to counter host defenses, supporting a cohesive viral-host interaction theme.","confidence":"High","size":27,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":10},{"id":"GO:0075713","count":7},{"id":"GO:0046718","count":7},{"id":"GO:0006278","count":6},{"id":"GO:1903704","count":6}]},{"hash":"2011045277902139104","title":"Ubiquitin-Dependent Immune Signaling and Stress Response","description":"The cluster is strongly associated with protein deubiquitination and immune signaling terms (T cell receptor signaling, MHC I antigen processing/presentation, TNF signaling, and regulation of inflammatory responses), suggesting a module where ubiquitin turnover modulates immune pathways. The presence of metal/ion stress responses (cadmium, zinc, salt) alongside these indicates broader stress-regulatory roles. Anaphase-promoting complex\u2013dependent catabolic process hints at protein turnover linked to cell cycle control, tying in ubiquitin-mediated regulation. Overall, a cohesive theme around ubiquitin-regulated immune signaling with stress response involvement.","confidence":"Medium","size":27,"edges":322,"triangles":2474,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":13},{"id":"GO:0050852","count":7},{"id":"GO:0002479","count":7},{"id":"GO:0046686","count":7},{"id":"GO:0009651","count":7}]},{"hash":"1301602128902210676","title":"Embryonic organogenesis and morphogenesis","description":"These terms cluster around embryonic development of multiple organs and tissues (pituitary, neural crest, cranial skeleton, pancreas, lung, ureteric bud) and general multicellular development, with a regulatory term indicating transcriptional control during these processes. The pattern supports a unifying theme of embryonic organ development and morphogenesis.","confidence":"High","size":27,"edges":185,"triangles":444,"max_degree":21,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0021983","count":12},{"id":"GO:0001755","count":10},{"id":"GO:0090190","count":10},{"id":"GO:0048557","count":10}]},{"hash":"2271840014697171724","title":"Mitochondrial Energy Metabolism","description":"This cluster is enriched with terms centered on mitochondrial energy production, including mitochondrial ATP synthase assembly and aerobic respiration, with supporting links to lipid metabolism and ion transport. The presence of translation and signaling terms suggests coordination with broader cellular regulation, but the core theme remains mitochondrial energy metabolism and related pathways.","confidence":"Medium","size":27,"edges":299,"triangles":1993,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0033615","count":2},{"id":"GO:0009236","count":2},{"id":"GO:0009060","count":2},{"id":"GO:0006814","count":2},{"id":"GO:0006412","count":2}]},{"hash":"2298573491598859339","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0006313","count":3},{"id":"GO:0071544","count":2},{"id":"GO:0050992","count":2},{"id":"GO:1901909","count":2}]},{"hash":"2136629482348508075","title":"Mitotic Cell Cycle and Spindle Assembly","description":"This cluster is strongly enriched for mitosis-related GO terms, including mitotic cell cycle, mitotic spindle assembly, cell division, and APC-dependent catabolic processes, which together indicate a cohesive role in mitotic progression and chromosome segregation. Some terms refer to general signaling or stress responses (cadmium, hypoxia) that are less central to the core function but do not outweigh the mitotic signal.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":8},{"id":"GO:0090307","count":8},{"id":"GO:0043547","count":7},{"id":"GO:2001162","count":7},{"id":"GO:0071276","count":7}]},{"hash":"335435114648644582","title":"Neurovascular and retinal development","description":"The top GO terms cluster around nervous system development (forebrain), retinal/eye development and visual perception, along with vascular-angiogenic processes and heart development, suggesting a shared theme of coordinated development across neural, ocular, and cardiovascular tissues, aided by integrin and calcium signaling during organogenesis.","confidence":"Medium","size":27,"edges":12,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0030900","count":4},{"id":"GO:0007229","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0051965","count":3}]},{"hash":"1673318324189229856","title":"Retroviral DNA integration and latency","description":"The cluster\u2019s top GO terms converge on viral DNA processing and lifecycle steps: DNA recombination, DNA integration, DNA replication, RNA-templated DNA synthesis, and especially the establishment of integrated proviral latency, plus viral penetration into the host nucleus. Together these point to retroviral-like processes of entering the nucleus, reverse-transcribing and integrating into the host genome, and maintaining latency. Peripheral terms about symbiont-host interactions do not outweigh this central theme.","confidence":"High","size":27,"edges":294,"triangles":1862,"max_degree":26,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":11},{"id":"GO:0006278","count":9},{"id":"GO:1903704","count":9},{"id":"GO:0075713","count":9},{"id":"GO:0015074","count":9}]},{"hash":"1043884450117687385","title":"Neural signaling and calcium-mediated responses","description":"The cluster is dominated by GO terms related to neural communication and calcium signaling, including neuropeptide signaling, dopamine uptake, sensory perception of pain, and release of sequestered calcium into the cytosol. Additional terms point to temperature-related processes and thermogenesis, which often connect to neural and metabolic regulation. While some terms touch on inflammation or muscle regulation, the core theme appears to be neuronal signaling governed by calcium dynamics, with ancillary metabolic and modulatory connections. ","confidence":"Medium","size":27,"edges":18,"triangles":0,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":27},{"id":"GO:0071502","count":27},{"id":"GO:0002024","count":27},{"id":"GO:0019233","count":27},{"id":"GO:0043950","count":26}]},{"hash":"2272039603756591143","title":"Neural and brain development","description":"The top GO terms are dominated by nervous system and brain development, including forebrain/midbrain/brain development and trigeminal ganglion development, plus multicellular organism development. This pattern suggests the proteins collectively function in neural development and brain region specification. Some terms (response to lipopolysaccharide, transcriptional regulation) appear as broader or secondary associations, but the strongest signal is neural development. No edges are reported among proteins, aligning with a dispersed developmental protein set.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":7},{"id":"GO:0061551","count":6},{"id":"GO:0000122","count":6},{"id":"GO:0032496","count":5},{"id":"GO:0007626","count":5}]},{"hash":"88220273794767990","title":"Neuropeptide Signaling and Blood Pressure Regulation","description":"These proteins are annotated with GO terms centered on neuropeptide signaling, dopamine uptake regulation, vasopressin-mediated control of systemic blood pressure, renin secretion, and related inflammatory signaling. The convergence on neuropeptide pathways and hormone\u2013vascular regulation (vasopressin and renin) suggests a neuroendocrine signaling module that modulates neural communication and cardiovascular homeostasis, with ancillary links to chemokine and IL-1\u03b2\u2013related immune signaling.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":27},{"id":"GO:0032651","count":27},{"id":"GO:0007218","count":27},{"id":"GO:2000724","count":27},{"id":"GO:0090075","count":27}]},{"hash":"1677419507025659887","title":"K48/K11 Ubiquitin Deubiquitination","description":"Most prominent GO terms in this cluster are about deubiquitination of ubiquitin chains, specifically free ubiquitin chain depolymerization and K48- and K11-linked deubiquitination. This strongly suggests the cluster centers on ubiquitin-mediated protein turnover and editing, i.e., deubiquitinating activity. Some neuronal development and death pathway terms appear as minor associations, but the core theme is ubiquitin chain processing. ","confidence":"Medium","size":27,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010995","count":1},{"id":"GO:0071108","count":1},{"id":"GO:0010606","count":1},{"id":"GO:1903070","count":1},{"id":"GO:0035192","count":1}]},{"hash":"1566219775994268013","title":"Developmental signaling and cytoskeletal remodeling","description":"The GO terms cluster around developmental processes (retina development, uterus development, morphogenesis) alongside receptor-mediated signaling pathways (EGFR, ephrin) and cytoskeletal dynamics (actin filament bundle and filopodium assembly). This points to a theme of signaling-driven morphogenesis and actin remodeling rather than a single tissue-specific function. Confidence: Medium","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":3},{"id":"GO:0007584","count":2},{"id":"GO:0071372","count":2},{"id":"GO:0043154","count":2},{"id":"GO:0060065","count":2}]},{"hash":"1514302071060989303","title":"Mitochondrial Transport and Metabolism","description":"The top GO terms cluster around mitochondrial function: malate-aspartate shuttle, transport of alpha-ketoglutarate and ornithine, manganese ion transport, and mitochondrial membrane fission, all pointing to mitochondrial metabolism and dynamics. Additional terms about insulin signaling and amino acid starvation suggest metabolic regulation that interfaces with mitochondria. Confidence in this theme is Medium.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060546","count":5},{"id":"GO:0043490","count":4},{"id":"GO:0070542","count":4},{"id":"GO:0034198","count":4},{"id":"GO:0000066","count":4}]},{"hash":"1128622702997888226","title":"Proviral integration and latency establishment","description":"These proteins are annotated with GO terms tied to DNA integration, proviral latency establishment, DNA recombination, transposition, and reverse transcription, plus host-interaction terms like viral entry, RNA silencing suppression, and apoptosis modulation. The combined signals point to retroelement/viral lifecycle functions centered on integrating viral DNA into the host genome and establishing latency, rather than a single cellular pathway. Therefore, the label reflects the core theme of proviral integration and latent state establishment.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":9},{"id":"GO:0075713","count":6},{"id":"GO:0006310","count":5},{"id":"GO:0046718","count":5},{"id":"GO:0006260","count":5}]},{"hash":"1891912788256523820","title":"Coagulation and vascular remodeling","description":"This cluster is dominated by terms related to hemostasis and vascular function: blood coagulation, plasminogen activation, fibrinolysis, vasoconstriction, and smooth muscle cell migration, all suggesting processes that regulate blood clotting and vascular remodeling. Inflammation-related terms (response to lipopolysaccharide) align with vascular-immune interactions, while a few terms like axon extension or synaptic transmission appear peripheral. Overall, the core theme is coagulation and vascular remodeling. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":17},{"id":"GO:0071260","count":17},{"id":"GO:0045907","count":17},{"id":"GO:0031639","count":17},{"id":"GO:0051968","count":17}]},{"hash":"834201238419330771","title":"Unknown","description":"The GO terms span both microbial metabolic processes (nitrate assimilation, menaquinone biosynthesis) and diverse animal signaling/development pathways (T cell receptor signaling, heart development, neurotrophin TRK signaling, ERK cascade, responses to mechanical stimuli and nitric oxide, TGF-beta stimulus). There is no single cohesive theme that ties all functions together, so a specific, representative label cannot be assigned.","confidence":"","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042128","count":5},{"id":"GO:0050852","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0071560","count":4}]},{"hash":"476127294889377161","title":"Cranial nerve axon guidance and neural crest migration","description":"Dominated by axon guidance and neural crest\u2013related processes across cranial nerves and sensory structures: branchiomotor and trigeminal neuron axon guidance, commissural guidance, semaphorin-plexin signaling, inner ear receptor cell development, and neural crest migration, together with sympathetic neuron projection dynamics. This points to a cohesive theme of cranial sensory neuron pathfinding and neural crest\u2013driven cranial development.","confidence":"High","size":27,"edges":26,"triangles":5,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":8},{"id":"GO:0097491","count":7},{"id":"GO:0021785","count":7},{"id":"GO:0007413","count":7},{"id":"GO:1902287","count":7}]},{"hash":"2221022744948786293","title":"Cardiac signaling and electrophysiology","description":"The enriched GO terms point to heart-specific processes: regulation of atrial and SA node action potentials indicates direct involvement in cardiac electrophysiology; negative regulation of angiogenesis and multicellular development suggest developmental and vascular signaling linked to heart function; phosphatidylinositol-mediated signaling and NF-kappaB-related terms reflect membrane signaling and inflammatory pathways commonly active in cardiomyocytes; plasma membrane repair hints at membrane integrity dynamics in heart cells. Together these terms depict a cluster enriched for cardiac signaling and electrical activity, with supporting membrane and developmental processes.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001778","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0048015","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0098910","count":3}]},{"hash":"799692679125742923","title":"Ubiquitin-Proteasome and Autophagy in Immunity","description":"The terms show a strong emphasis on ubiquitin-dependent protein degradation and autophagy, coupled with immune processes (innate immunity, T cell proliferation, V(D)J recombination, TNF signaling). This suggests a cohesive theme where protein turnover pathways interface with immune signaling and lymphocyte development, with circadian regulation sometimes linked to immunity. Hence, a label focusing on ubiquitin-proteasome/autophagy roles in immunity is appropriate.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:0042752","count":8},{"id":"GO:0030433","count":8},{"id":"GO:1903265","count":8},{"id":"GO:0045087","count":8}]},{"hash":"1281501664624084733","title":"Neuroinflammation and neural development","description":"These proteins appear linked to inflammatory signaling (NF-kappaB, IL-1 pathways, chemokine production, neutrophil extravasation) as well as neural development processes (myelination, axonal fasciculation, synapse assembly) and sensory structure formation (otolith morphogenesis). The cluster seems to coordinate aspects of immune signaling with neural connectivity and sensory organ development, making this a coherent neuroinflammatory\u2013neurodevelopmental theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0014068","count":3},{"id":"GO:2000661","count":3},{"id":"GO:0042552","count":3},{"id":"GO:0007413","count":3}]},{"hash":"1402772238161858375","title":"Developmental Morphogenesis and Cell Adhesion","description":"The cluster is enriched for cell adhesion and multiple morphogenesis-related terms (skin, kidney, salivary gland) plus regulatory notes on cytoskeletal and signaling processes, suggesting a theme of tissue morphogenesis and adhesion rather than a single, narrow pathway.","confidence":"Medium","size":27,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0060665","count":2},{"id":"GO:0032516","count":2},{"id":"GO:0043589","count":2}]},{"hash":"977072640288783009","title":"GPCR-cAMP Signaling in Neurovascular Regulation","description":"The cluster is dominated by GO terms for adenylate cyclase-activating GPCR signaling, cAMP pathways, and related modulation of Rho signaling, neuropeptide signaling, and neurotransmitter processes (dopamine uptake), all converging on vascular and neural control of blood pressure and muscle relaxation, with additional energy-related terms reflecting cellular metabolism in muscle tissue.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":27},{"id":"GO:0035025","count":27},{"id":"GO:0045777","count":27},{"id":"GO:0022900","count":27},{"id":"GO:0043950","count":26}]},{"hash":"1301540426330527766","title":"Neurovascular GPCR signaling and muscle regulation","description":"These proteins cluster around GPCR-mediated signaling (adenylate cyclase-activating pathways) and neuropeptide signaling, with related roles in dopamine uptake, vascular smooth muscle/cardiac differentiation, and muscle relaxation. The GO terms collectively point to signaling processes governing neural and cardiovascular/muscle function, making a neurovascular signaling and muscle regulation theme plausible, despite one outlier term (electron transport chain). ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":26},{"id":"GO:0035025","count":26},{"id":"GO:0045777","count":26},{"id":"GO:0022900","count":26},{"id":"GO:0043950","count":25}]},{"hash":"1026360853209743552","title":"NF-kappaB signaling and calcium-dependent processes","description":"The top GO terms indicate a core focus on NF-kappaB transcription factor activity regulation and canonical NF-kappaB signaling, with additional links to calcium sensing and downstream functions such as synaptic vesicle endocytosis and cardiac electrophysiology (atrial and SA node action potentials). There are also ancillary terms related to ubiquitination and development, suggesting a broader signaling network rather than a single tissue-specific role. Overall, the cluster seems to group proteins involved in NF-kappaB\u2013mediated transcriptional regulation intertwined with calcium-dependent signaling that affects neuronal and cardiac contexts, giving a moderate level of confidence in this label.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0043123","count":3},{"id":"GO:1900242","count":3},{"id":"GO:0098910","count":2},{"id":"GO:0007275","count":2}]},{"hash":"2225669985902797289","title":"NF-kappaB signaling and apoptosis regulation","description":"The top GO terms are dominated by NF-kappaB transcription factor activity regulation and canonical NF-kappaB signaling, along with apoptosis-related processes (death-inducing signaling complex assembly, activation of proteases in apoptosis). This suggests a cluster of proteins involved in NF-kB\u2013mediated signaling and cell fate decisions, with some broader signaling roles reflected by a few peripheral terms.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0006919","count":4},{"id":"GO:0071550","count":4},{"id":"GO:0043123","count":4},{"id":"GO:0090557","count":4}]},{"hash":"2224605039684945392","title":"RNA processing and gene expression regulation","description":"The top terms center on spliceosome-mediated mRNA splicing, mRNA processing and export, translation initiation regulation, and transcription, indicating a cohesive module of RNA biogenesis and gene expression control. A developmental term is present but the dominant signals refer to RNA metabolism and expression regulation.","confidence":"High","size":26,"edges":260,"triangles":1496,"max_degree":25,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0048701","count":6},{"id":"GO:0031047","count":6},{"id":"GO:0045292","count":6}]},{"hash":"576299102700335034","title":"Axon guidance and neural crest migration","description":"The dominant GO terms point to neural development and axon pathfinding, including semaphorin-plexin signaling, sympathetic neuron projection guidance/extension, branchiomotor neuron axon guidance, trigeminal nerve organization, and axonal fasciculation. Immune and lipoprotein transport terms are present but are less cohesive with the main theme, so the label focuses on neural development and axon guidance.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042953","count":8},{"id":"GO:0006958","count":7},{"id":"GO:0036486","count":6},{"id":"GO:1902287","count":6},{"id":"GO:0007413","count":6}]},{"hash":"650877987635291265","title":"Axon guidance and neural development","description":"This cluster is dominated by terms related to nervous system wiring and neuron development, including semaphorin-plexin signaling in axon guidance, branchiomotor neuron axon guidance, trigeminal nerve organization, axonal fasciculation, and sympathetic neuron projection guidance, with supporting signals from sensory perception of sound. While a couple terms touch unrelated processes (ammonium transport, T cell signaling), the strong presence of axon guidance and neural patterning terms supports a focused neural development theme.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:2000249","count":2},{"id":"GO:0050860","count":2},{"id":"GO:0070634","count":2},{"id":"GO:0097491","count":2},{"id":"GO:0021785","count":2}]},{"hash":"1589969744942577391","title":"Ubiquitin-Proteasome Regulation and Heterochromatin Silencing","description":"The cluster shows strong signals for ubiquitin-dependent pathways (ERAD, SCF, K11-linked ubiquitination) alongside roles in heterochromatin formation/maintenance at subtelomeric and mating-type loci, including negative regulation of silencing. This suggests proteins linked to proteolysis that interface with chromatin silencing mechanisms, coordinating protein turnover with chromatin regulation in this context.","confidence":"Medium","size":26,"edges":242,"triangles":1311,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030433","count":17},{"id":"GO:0051865","count":17},{"id":"GO:0030466","count":17},{"id":"GO:0031939","count":17},{"id":"GO:0006344","count":17}]},{"hash":"764886919632181511","title":"DNA repair and nucleic acid metabolism","description":"Top terms show strong enrichment for DNA processing and repair (DNA recombination, DNA catabolic process) with supporting nucleic acid\u2013related activities. Some terms imply stress responses (xenobiotic stimulus, cAMP signaling) and a skin-related process (corneocyte development), which can be associated with DNA repair proteins linked to epidermal differentiation (XP-related). Overall, the cluster appears to center on nucleic acid metabolism and genome maintenance.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":9},{"id":"GO:0006308","count":5},{"id":"GO:0042493","count":5},{"id":"GO:0090502","count":5},{"id":"GO:0071320","count":5}]},{"hash":"1510210149747040575","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":13},{"id":"GO:0051607","count":12},{"id":"GO:0042787","count":11},{"id":"GO:0030433","count":9},{"id":"GO:0000185","count":8}]},{"hash":"1885018497286257611","title":"Embryonic Heart and Organ Morphogenesis","description":"The proteins in this cluster are enriched for heart development, pulmonary myocardium development, organ induction, and various embryonic morphogenesis processes (hindlimb, cranial skeleton, habenula). Although there is some regulatory signal (negative regulation of transcription by RNA polymerase II), the dominant theme is embryonic organ and tissue formation, especially cardiac and muscular/musculoskeletal contexts. This supports a label focused on embryonic heart and organ morphogenesis.","confidence":"High","size":26,"edges":15,"triangles":1,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0007507","count":10},{"id":"GO:0007275","count":9},{"id":"GO:0003350","count":9},{"id":"GO:0001764","count":9}]},{"hash":"2170133404365919865","title":"Multi-tissue signaling and growth regulation","description":"The top GO terms cluster around major signaling pathways (T cell receptor, insulin receptor) and processes that regulate cell proliferation and kinase activity, complemented by neural development and axon regeneration terms. This suggests a shared theme of signal transduction governing controlled growth/proliferation across diverse tissues, including immune, neural, cardiac, and metabolic contexts.","confidence":"High","size":26,"edges":58,"triangles":49,"max_degree":19,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0050852","count":23},{"id":"GO:0021697","count":23},{"id":"GO:0060020","count":23},{"id":"GO:0048679","count":23},{"id":"GO:0008286","count":23}]},{"hash":"353680444914586875","title":"Immune Activation and Apoptosis Regulators","description":"The top GO terms predominantly point to immune signaling (T cell receptor signaling, interleukin-12 response, lipopolysaccharide signaling) and apoptosis pathways (execution phase of apoptosis, intrinsic ER stress\u2013induced apoptotic signaling, JNK cascade, NF-kappaB-related activity). A few terms like ribosome biogenesis and neural tube closure appear as noise outliers, suggesting some functional diversity or annotation overlap among the proteins. Overall, the cluster centers on immune activation coupled with programmed cell death processes, justifying this label, albeit with moderate confidence due to heterogeneity and lack of edge-based cohesion.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0070671","count":2},{"id":"GO:0097194","count":2},{"id":"GO:0046330","count":2},{"id":"GO:0050852","count":2}]},{"hash":"1999627658597613393","title":"Membrane lipid biosynthesis and remodeling","description":"This cluster is dominated by lipid metabolism terms: ether lipid biosynthesis, phosphatidylcholine remodeling, cardiolipin remodeling, CDP-diacylglycerol biosynthesis, and platelet activating factor biosynthesis, pointing to coordinated membrane lipid production/remodeling. Additional terms hint at links to mitochondrial energy and some immune signaling, but the lipid-focused functions most strongly define the cluster.","confidence":"Medium","size":26,"edges":110,"triangles":250,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0070970","count":7},{"id":"GO:0008611","count":6},{"id":"GO:0036151","count":6},{"id":"GO:0016024","count":6},{"id":"GO:0010143","count":6}]},{"hash":"267171926451823594","title":"Neural signaling and sensory perception","description":"This cluster is enriched for GO terms related to neural communication and sensory functions: dopaminergic synaptic transmission, visual perception, perception of pain, and signaling pathways like the ERK1/2 cascade and protein phosphorylation. Although some terms like heart development and brain renin-angiotensin system appear, the dominant themes point to neuronal signaling and sensory processing.","confidence":"High","size":26,"edges":283,"triangles":1754,"max_degree":25,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":21},{"id":"GO:0019233","count":21},{"id":"GO:0070374","count":21},{"id":"GO:0007601","count":20},{"id":"GO:0071380","count":20}]},{"hash":"1176020739929266993","title":"Mitotic chromosome dynamics and vesicle trafficking","description":"This cluster is driven by mitosis-related GO terms (cell division, exit from mitosis, mitotic chromosome condensation, nucleus organization), alongside vesicle trafficking functions (protein retention in Golgi, membrane fission, regulation of exosomal secretion). A couple of development-specific terms (lens maintenance, follicle cell formation) likely reflect broader tissue roles rather than core cluster function, and one obsolete term is likely noise. Overall, the prevailing theme links chromosome dynamics during mitosis with secretory/trafficking pathways.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:1902188","count":3},{"id":"GO:0045053","count":3},{"id":"GO:0090148","count":3},{"id":"GO:0010458","count":3}]},{"hash":"133820922121460927","title":"Neural lipid catabolism and vascular development","description":"The top GO terms are dominated by lipid catabolic processes (triglyceride, monoacylglycerol, phosphatidylserine) with additional neural-vascular signals (brain development, positive regulation of angiogenesis, endocannabinoid signaling). Although other catabolic processes appear, the strongest cohesive theme links lipid metabolism to neural development and vascular growth, justifying a label focused on neural lipid catabolism and associated vascular development.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019433","count":6},{"id":"GO:0006660","count":5},{"id":"GO:0052651","count":5},{"id":"GO:0030245","count":5},{"id":"GO:2000124","count":5}]},{"hash":"446705199531837232","title":"Neuropeptide signaling and cardiovascular regulation","description":"The cluster is dominated by GO terms related to neuropeptide signaling, vasopressin-mediated blood pressure regulation, renin secretion, dopamine-related synaptic signaling, and smooth muscle relaxation, pointing to a neuroendocrine control of cardiovascular function. While a few immune-related terms appear, the core theme is neuropeptide and hormonal signaling governing vascular tone and blood pressure.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":26},{"id":"GO:0032651","count":26},{"id":"GO:0007218","count":26},{"id":"GO:2000724","count":26},{"id":"GO:0090075","count":26}]},{"hash":"855853079695727253","title":"Neural and Immune Signaling Networks","description":"The cluster centers on key signaling pathways (ERK/JNK cascades, Roundabout axon guidance, Hedgehog via Smoothened) and T cell receptor signaling, along with nervous system development and regulation of synaptic vesicle exocytosis. Together these terms point to a cohesive group of proteins involved in diverse signal transduction processes in neural development and immune signaling, with some synaptic function emphasis. ","confidence":"High","size":26,"edges":242,"triangles":1159,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":12},{"id":"GO:0035385","count":12},{"id":"GO:0050852","count":12},{"id":"GO:0007399","count":12},{"id":"GO:0043552","count":11}]},{"hash":"1494364051981392490","title":"Antiviral Innate Immune Signaling","description":"Based on the top GO terms, the proteins cluster around innate antiviral defense: cellular response to exogenous dsRNA, cellular response to type I interferon, and general innate immune response, including regulation of virus defense. Some terms like cell division, histone methylation, GPCR signaling, and ubiquitination appear ancillary, suggesting pleiotropic roles or regulatory connections, but the dominant theme is antiviral innate immunity and interferon-mediated signaling.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0071360","count":6},{"id":"GO:0071357","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0050689","count":6}]},{"hash":"2034888775436263805","title":"Retroviral Integration and Latency","description":"This cluster is dominated by GO terms tied to retroviral life cycle steps: DNA integration, RNA-templated DNA biosynthesis (reverse transcription), DNA recombination, and the establishment of integrated proviral latency, plus viral entry into the host and penetration into the nucleus. The additional terms about symbiont entry and host defense modulation align with typical virus-host interaction themes, supporting a cohesive retroviral replication/latency signature.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":7},{"id":"GO:0006310","count":6},{"id":"GO:0075713","count":6},{"id":"GO:0046718","count":6},{"id":"GO:0075732","count":5}]},{"hash":"414206721076337448","title":"Blood cell differentiation and transcription regulation","description":"This cluster shows strong signals for hematopoietic differentiation, notably granulocyte and erythrocyte development, alongside transcriptional regulation (negative regulation of transcription by RNA polymerase II). While a few terms are obsolete or broad, the prevailing pattern points to genes involved in blood cell lineage specification and control of gene expression, justifying a label focused on blood cell differentiation with transcriptional regulation.","confidence":"Medium","size":26,"edges":8,"triangles":3,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0021983","count":8},{"id":"GO:0019835","count":7},{"id":"GO:0000122","count":7},{"id":"GO:0030851","count":7}]},{"hash":"825599121044064328","title":"Mitochondrial respiration and ribosome assembly","description":"The top GO terms are dominated by mitochondrial processes: assembly of respiratory chain complex II, electron transport NADH to ubiquinone, and mitochondrial ribosome assembly, indicating the proteins participate in mitochondrial energy production and translation. Although there are other terms touching on cell cycle and development, the recurring theme is mitochondrial function.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034553","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0000209","count":2}]},{"hash":"1809025581349869651","title":"Retroviral integration and proviral latency","description":"The top GO terms cluster around viral DNA integration, proviral latency establishment, and steps of viral entry into the host nucleus, plus RNA-templated DNA synthesis and DNA transposition, consistent with retroelement activity. These points suggest a core theme of retroviral-like genome integration and latent infection, with additional terms reflecting host response/modulation and symbiont interactions.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":7},{"id":"GO:0075713","count":5},{"id":"GO:0075732","count":5},{"id":"GO:0039651","count":5},{"id":"GO:0046718","count":5}]},{"hash":"1887737920845512020","title":"NF-kB-driven innate immune signaling","description":"The top GO terms are dominated by canonical NF-kappaB signaling, MyD88-dependent TLR signaling, and IL-1\u2013mediated pathways, all pointing to innate immune activation and inflammatory responses. While a few terms touch on thymus development or broader signaling like Wnt, the prevailing theme is NF-kB\u2013mediated immune signaling. This suggests the cluster represents proteins involved in innate immune sensing and transcriptional responses to pathogens. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001240","count":3},{"id":"GO:0048538","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0002755","count":3},{"id":"GO:0051092","count":3}]},{"hash":"334428053275823633","title":"Rho GTPase Signaling and Filopodium Dynamics","description":"The top GO terms cluster around Rho-family GTPase\u2013mediated signaling, regulation and assembly of filopodia, and neural morphogenesis (including nerve branching), with supporting signals related to cytoskeletal remodeling, dopamine response, and heart development. This points to a cohesive theme of cytoskeletal dynamics and protrusion formation governed by Rho/Rho-like GTPases, relevant to neurite outgrowth and development.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":4},{"id":"GO:0007264","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0035023","count":4},{"id":"GO:1903206","count":3}]},{"hash":"1293740169680896400","title":"Neuronal signaling and synapse assembly","description":"The cluster's top GO terms cluster around neural development and synaptic organization\u2014axonal fasciculation, positive regulation of synapse assembly, and ERK signaling\u2014suggesting proteins involved in neuronal signaling and synaptic connectivity. Some terms (heart development, Fc-epsilon receptor signaling) are less related and may reflect annotation noise or broader roles.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038095","count":3},{"id":"GO:0032516","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0045163","count":2}]},{"hash":"1641491182384817496","title":"Metal ion and amino acid transport","description":"Dominant GO terms describe transmembrane transport of iron, manganese, cadmium, and arginine, indicating a membrane transport cluster for metals and amino acids; some immune-related terms may be annotations noise rather than a shared function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032632","count":1},{"id":"GO:0006876","count":1},{"id":"GO:0070574","count":1},{"id":"GO:0002309","count":1},{"id":"GO:0002827","count":1}]},{"hash":"679049486513848744","title":"Thermogenesis-Linked Dopaminergic GPCR Signaling","description":"The proteins in this cluster are enriched for temperature response and thermogenesis, including diet-induced thermogenesis, and are involved in GPCR-cAMP signaling driven by dopamine receptors, which also ties to regulation of membrane potential and blood pressure. The inclusion of electron transport chain terms suggests a link to mitochondrial energy production underpinning thermogenic processes, supporting a cohesive theme of thermogenic energy metabolism and dopaminergic signaling, though one term (sensory perception of pain) is less central.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":20},{"id":"GO:0010579","count":20},{"id":"GO:0045777","count":20},{"id":"GO:0022900","count":20},{"id":"GO:0002024","count":20}]},{"hash":"1566517947092375246","title":"Neuropeptide signaling and thermoregulation","description":"The cluster\u2019s top GO terms point to neural signaling (neuropeptide signaling, dopamine uptake), sensory perception of pain, and temperature-related processes (temperature stimulus, diet-induced thermogenesis), along with vasopressin- and autonomic-regulated vascular and cardiac functions. Together these terms suggest proteins involved in neuroendocrine control of temperature, pain modulation, and cardiovascular tone, making a neuropeptide/thermoregulatory theme most representative. High","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":26},{"id":"GO:0002024","count":26},{"id":"GO:0019233","count":26},{"id":"GO:0043950","count":25},{"id":"GO:0032651","count":25}]},{"hash":"369878844480387686","title":"Cardiac GPCR-cAMP-ERK Signaling","description":"The top GO terms cluster around GPCR signaling that activates adenylate cyclase and cAMP, followed by ERK1/2 and Rho signaling, and include heart development and regulation of blood pressure. Neuropeptide signaling and IL-1\u03b2 regulation tie into neuroendocrine/inflammatory modulation of cardiac function, while electron transport chain aligns with cardiac energy metabolism. Overall, this set reflects a cardiovascular signaling network centered on GPCR-driven pathways and heart development/differentiation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":26},{"id":"GO:0035025","count":26},{"id":"GO:0045777","count":26},{"id":"GO:0007507","count":26},{"id":"GO:0022900","count":26}]},{"hash":"1488764359255556100","title":"Axon guidance and neural development","description":"This cluster is dominated by GO terms for neuronal pathfinding and wiring, including axonogenesis, neural crest cell migration, semaphorin-plexin signaling, axonal fasciculation, and multiple neuron projection guidance terms (sympathetic, branchiomotor, trigeminal). The presence of a synapse assembly regulation term further supports roles in connectivity formation. An innate immune response term may be incidental. Overall, the proteins likely participate in axon guidance and neural development.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060385","count":5},{"id":"GO:0036486","count":4},{"id":"GO:1902287","count":4},{"id":"GO:0007413","count":4},{"id":"GO:0097491","count":4}]},{"hash":"2160640268135084306","title":"Retroviral integration and transposition","description":"The cluster centers on DNA integration and transposition, including RNA-templated DNA synthesis and establishment of proviral latency, which together point to retroelement/retrovirus activity and transposon dynamics (viral entry into the nucleus and interactions with host defenses are consistent with this theme, despite some symbiont-related terms present).","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0006313","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0039651","count":3}]},{"hash":"594724387446514117","title":"Neural Development and Synaptic Plasticity","description":"The cluster is dominated by GO terms tied to neural development and synaptic function, such as cerebellar cortex development, excitatory postsynaptic potentials, response to environmental enrichment, and regulation of synaptic plasticity, indicating a neural development/synaptic modulation module. Other terms hint at broader developmental signaling and tissue remodeling, but the neural theme best ties the set together.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0090648","count":24},{"id":"GO:0021695","count":24},{"id":"GO:0097350","count":24},{"id":"GO:0060079","count":24},{"id":"GO:0090188","count":24}]},{"hash":"2251841366048447886","title":"Innate Immune Activation and Inflammation","description":"The cluster is dominated by GO terms tied to innate immunity and inflammatory signaling: cellular response to fungal origin, phagocytosis recognition, lectin pathway complement activation, basophil activation, arachidonate secretion, and platelet activation. This points to a cohesive theme of immune activation and inflammatory response. A few developmental terms (mesonephric duct and tubule morphogenesis, cartilage condensation) are present but likely secondary or reflective of shared gene functions, rather than the core theme. ","confidence":"Medium","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":26},{"id":"GO:0090238","count":25},{"id":"GO:0001502","count":25},{"id":"GO:0006910","count":25},{"id":"GO:0001867","count":25}]},{"hash":"1500181698106570287","title":"Synapse formation and spine morphogenesis","description":"The terms emphasize neuronal synaptic localization, receptor clustering, and dendritic spine development, with Rho signaling guiding cytoskeletal remodeling and GPCR signaling at synapses; Golgi localization likely reflects trafficking to synapses. A few polarity-related terms exist, but the core pattern supports synaptic organization and spine morphogenesis.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051683","count":5},{"id":"GO:0043113","count":5},{"id":"GO:0035418","count":5},{"id":"GO:0060997","count":5},{"id":"GO:0008285","count":5}]},{"hash":"1339811446856083312","title":"Ubiquitin-Mediated TNF/NF-\u03baB Innate Signaling","description":"The top GO terms point to ubiquitin-dependent protein catabolic processes, various forms of ubiquitination (including K63-linked), autoubiquitination, and key signaling events in TNF- and NF-\u03baB pathways, all within an innate immune context. This suggests a cohesive module of proteins regulating ubiquitin-dependent signaling and innate immune activation rather than general degradation, hence a focused name tied to ubiquitin-regulated TNF/NF-\u03baB signaling.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:1903265","count":12},{"id":"GO:1903721","count":11},{"id":"GO:0090073","count":11},{"id":"GO:0051865","count":11}]},{"hash":"1968090457421009971","title":"Unknown","description":"The GO terms are diverse (lipid metabolism, DNA transposition/integration, immune response, development) with little clear overlap, and there are no connecting edges. This mix makes it hard to assign a single coherent function to the cluster.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003007","count":2},{"id":"GO:0035360","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0090305","count":2}]},{"hash":"1521594948448987050","title":"DNA transposons and proviruses","description":"The cluster is dominated by GO terms tied to mobile genetic elements: DNA integration, transposition, retrotransposition, proviral latency, and viral entry into the host nucleus. This points to transposable elements and integrated viral/proviral sequences; a few peripheral terms may reflect broader host interaction annotations but do not override the central transposon/provirus theme.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0075713","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0046718","count":4}]},{"hash":"535965033830927796","title":"Innate Antiviral Defense and Inflammatory Signaling","description":"The cluster is dominated by GO terms tied to antiviral defense and innate immunity, including defense response to virus, innate immune response, MyD88-dependent TLR signaling, inflammatory response, and pyroptotic inflammation. Ubiquitination appears as a regulatory mechanism in these pathways. A few terms (e.g., mitotic spindle assembly, obsolete entries) are likely artifacts, but the overall signal points to a coordinated antiviral innate immune/inflammatory response.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032088","count":10},{"id":"GO:0051607","count":10},{"id":"GO:0016567","count":10},{"id":"GO:0070269","count":9},{"id":"GO:0006954","count":9}]},{"hash":"1907720905609883506","title":"Neural and sensory development","description":"The cluster\u2019s top GO terms point to development and maturation of neural and sensory tissues\u2014sympathetic ganglion development, commissural neuron axon guidance, sensory perception of sound, and synapse maturation\u2014with Hedgehog/PKC signaling modulation also tying into neural development. While a couple terms hint at broader ectodermal processes (bone morphogenesis, hair follicle development), the strongest signal is neural and sensory system formation and maturation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061549","count":3},{"id":"GO:0071679","count":3},{"id":"GO:0060349","count":2},{"id":"GO:0001942","count":2},{"id":"GO:0055114","count":2}]},{"hash":"1019707441234859460","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0051084","count":1},{"id":"GO:0033617","count":1},{"id":"GO:0022417","count":1},{"id":"GO:0032543","count":1}]},{"hash":"684768235676880016","title":"GPCR-Mediated Neurotransmitter Signaling","description":"The top GO terms center on dopamine and adrenergic receptor signaling, PLC and cAMP pathways, and phototransduction, all typical of G protein-coupled receptor signaling across neural, sensory, and cardiovascular contexts.","confidence":"High","size":25,"edges":217,"triangles":1023,"max_degree":24,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":14},{"id":"GO:0007507","count":13},{"id":"GO:0071502","count":12},{"id":"GO:0002024","count":12},{"id":"GO:0043950","count":11}]},{"hash":"64661282720486181","title":"Chromatin remodeling and piRNA processing","description":"The top GO terms indicate genome-centric functions: chromatin remodeling, positive regulation of DNA binding, and DNA integration, plus piRNA processing, pointing to chromatin dynamics and transposon genome defense. Other immune-related terms appear less central and may reflect annotation noise. Overall, the cluster is best described by chromatin/genomic regulation with piRNA involvement.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0071353","count":2},{"id":"GO:0043044","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0043388","count":2}]},{"hash":"1511330642594267473","title":"Proviral latency and DNA integration","description":"This cluster centers on viral genome integration and latent phases, with GO terms for proviral latency establishment, DNA integration, RNA-templated DNA biosynthesis (reverse transcription), and viral entry into the host nucleus, plus DNA replication and recombination. The presence of RNAi regulation terms suggests host antiviral responses and viral countermeasures. A few outlier terms reference symbiont interactions or seed growth, but the dominant theme is viral genome integration and latency.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0006278","count":3},{"id":"GO:1903704","count":3}]},{"hash":"1620398190416428698","title":"Innate inflammation and pyroptosis","description":"The top terms strongly point to innate immune activation and inflammatory cell death, including pyroptosis, IL-1\u03b2 production, and TLR4 signaling, with supportive notes on xenophagy and ubiquitination; a few terms (mitotic spindle assembly) may be less related noise, but do not override the dominant inflammatory/death theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070269","count":23},{"id":"GO:1990001","count":23},{"id":"GO:0045087","count":23},{"id":"GO:0090307","count":22},{"id":"GO:0016567","count":22}]},{"hash":"99223399269012829","title":"Synaptic Signaling and Cytoskeletal Remodeling","description":"Most terms describe synaptic signaling and plasticity, including regulation of synaptic plasticity by receptor localization to the synapse, ephrin receptor signaling, and SNARE complex assembly, plus actin filament bundle assembly pertinent to synaptic structure. A couple of terms (spindle assembly, muscle stretch, vitamin D response) are less clearly connected to synaptic function, so the label captures the primary theme with moderate confidence.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900383","count":10},{"id":"GO:0007205","count":10},{"id":"GO:1901187","count":10},{"id":"GO:0033280","count":10},{"id":"GO:0051225","count":9}]},{"hash":"1919315048512835407","title":"Pain and Thermo-sensory Neural Signaling","description":"This cluster centers on neural processes related to pain perception, temperature response, and drug-related modulation. Key terms include sensory perception of pain, cellular response to temperature stimulus, prostaglandin signaling, and dopaminergic/synaptic transmission, plus modulation of glutamatergic signaling and morphine response. Some terms like visual learning and diet-induced thermogenesis appear tangential but may reflect broader brain pathways involved in learning and energy balance. Overall, the functions point to a neural pain/thermosensory signaling theme with drug-response features.","confidence":"Medium","size":25,"edges":162,"triangles":372,"max_degree":19,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":22},{"id":"GO:0071502","count":21},{"id":"GO:0008542","count":21},{"id":"GO:0002024","count":21},{"id":"GO:0051930","count":20}]},{"hash":"1254303533417673588","title":"Unknown","description":"The top GO terms are a mix of viral-host interaction concepts (viral release, proviral latency, DNA integration, host apoptosis activation) and broad cellular/developmental processes (embryonic development, synapse assembly, cell cycle, mitochondrial assembly), with no clear, unified function tying the cluster together. Given 0 edges and a heterogeneous set of annotations, there isn\u2019t a coherent theme to assign a more specific label.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":3},{"id":"GO:0007626","count":3},{"id":"GO:0015074","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0075713","count":2}]},{"hash":"1532347287353139164","title":"Neural Development Signaling","description":"The cluster centers on nervous system development and neural signaling, with terms like nervous system development, hippocampus development, and ephrin receptor signaling, along with ROBO (Roundabout) signaling, Wnt, and Hedgehog (Smoothened) pathways. Downstream cues such as ERK1/2 cascade and PI3K activity tie these neural guidance and developmental signals together. While a few terms touch on other systems (T cell receptor signaling, kidney development), the predominant theme is neural development and its signaling networks.","confidence":"High","size":25,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043552","count":13},{"id":"GO:0050852","count":12},{"id":"GO:0035385","count":12},{"id":"GO:0070374","count":12},{"id":"GO:0007399","count":12}]},{"hash":"1078284176631997009","title":"Neuropeptide signaling and cardiovascular regulation","description":"The cluster centers on neuropeptide signaling, vasopressin- and renin-mediated regulation of blood pressure, and muscle relaxation, with supplementary dopamine uptake regulation and immune modulation terms, indicating a neuroendocrine/cardiovascular regulatory theme.","confidence":"Medium","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":25},{"id":"GO:0032651","count":25},{"id":"GO:0007218","count":25},{"id":"GO:2000724","count":25},{"id":"GO:0090075","count":25}]},{"hash":"1174365371170839703","title":"DNA Metabolism and Cell Cycle Regulation","description":"The cluster is dominated by nuclear processes: DNA-templated transcription, DNA repair, and mitotic cell cycle control (including negative regulation of G1/S). This points to proteins involved in transcription and genome maintenance during cell division. Some terms relate to redox homeostasis, stress response, and protein structure (protein homotrimerization), which may reflect supporting roles or broader cellular context. Overall, the common thread is DNA metabolism linked to cell cycle regulation, with ancillary metabolic and stress-related features.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0009409","count":2},{"id":"GO:0006552","count":2}]},{"hash":"2012183823545350411","title":"Neural development and signaling","description":"This cluster is enriched for nervous system development terms (nervous system development, brain development), roundabout and smoothened signaling pathways, and regulation of synaptic vesicle exocytosis, pointing to roles in neural patterning, connectivity, and neurotransmission. While a couple of terms (like T cell receptor signaling) are less directly related, the dominant theme across the top GO terms is neural development and synaptic signaling, justifying a neural development and signaling label.","confidence":"High","size":25,"edges":279,"triangles":1880,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035385","count":14},{"id":"GO:0007399","count":14},{"id":"GO:0050852","count":13},{"id":"GO:0007224","count":13},{"id":"GO:0001822","count":13}]},{"hash":"1532184141322001669","title":"Intracellular trafficking and immune signaling","description":"The terms cluster around vesicle transport (plasma membrane to endosome, endosome to melanosome, Golgi-to-ER retrograde transport) and signaling/immune processes (NF-kappaB regulation, JNK cascade, Wnt signaling, IL-23/T-helper 1 responses), with a note on cellular response to mechanical stimulus. This points to proteins coordinating intracellular trafficking with signaling in immune and stress-related contexts.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":2},{"id":"GO:0048227","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0035646","count":2},{"id":"GO:0071260","count":2}]},{"hash":"1685867307123104972","title":"Neuronal Synaptic Signaling and GTPase Regulation","description":"Cluster shows strong enrichment for long-term synaptic potentiation and synaptic vesicle exocytosis, plus regulation of small GTPases (Rho, Ras) and their signaling pathways. This indicates a core theme of neuronal synaptic transmission and cytoskeletal modulation via GTPase signaling, with some developmental terms present but still fitting the neuronal connectivity focus.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0060291","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0007264","count":5},{"id":"GO:0035023","count":5}]},{"hash":"1293346613383955554","title":"Neuroendocrine signaling and cardiovascular regulation","description":"This cluster centers on neuropeptide signaling and neuroendocrine control of vascular tone and blood pressure, with associated dopamine signaling, renin/vasopressin pathways, and immune chemokine regulation, suggesting a cohesive neuroendocrine-cardiovascular function theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":24},{"id":"GO:0032651","count":24},{"id":"GO:0007218","count":24},{"id":"GO:2000724","count":24},{"id":"GO:0090075","count":24}]},{"hash":"1504307256346881040","title":"Neuropeptide Signaling and Thermoregulation","description":"This cluster centers on neuronal and hormonal signaling pathways, including neuropeptide signaling, dopamine uptake regulation, and vasopressin-mediated blood pressure control, together with temperature-related processes like cellular response to temperature stimulus and diet-induced thermogenesis. These shared terms suggest a cohesive role in neuroendocrine regulation of body temperature and vascular/neuromuscular responses.","confidence":"High","size":25,"edges":5,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":24},{"id":"GO:0002024","count":24},{"id":"GO:0019233","count":24},{"id":"GO:0043950","count":23},{"id":"GO:0032651","count":23}]},{"hash":"98802186241389446","title":"Pain- and Inflammation-Related Signaling","description":"Top GO terms point to nociception and thermosensation (sensory perception of pain; cellular response to temperature stimulus; diet-induced thermogenesis) alongside immune/inflammatory processes (blood coagulation; eosinophil chemotaxis; regulation of IL-1 beta production). Additional terms hint at neuronal signaling and calcium/PKA pathways (negative regulation of voltage-gated calcium channels; regulation of cAMP-dependent protein kinase activity; GDNF production). Together, these suggest a cluster of proteins coordinating pain signaling, temperature response, and inflammatory responses.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":19},{"id":"GO:0071502","count":19},{"id":"GO:0002024","count":19},{"id":"GO:0007596","count":18},{"id":"GO:0032651","count":17}]},{"hash":"1339491362831444985","title":"Embryonic neural and organ morphogenesis","description":"The top GO terms cluster around developmental processes across multiple tissues and stages, especially neural development (brain, neural crest migration, retinal ganglion cell axon guidance, metencephalon development) and organ morphogenesis (uterus, ureteric bud branching, embryonic digestive tract morphogenesis, pulmonary myocardium development), with an additional note on transcriptional regulation during development. This suggests a cohesive theme of embryonic development and tissue morphogenesis rather than a single pathway.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0031290","count":4},{"id":"GO:0000122","count":4}]},{"hash":"1833889008879804848","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":4},{"id":"GO:0015074","count":3},{"id":"GO:0035556","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0048026","count":2}]},{"hash":"1976055320966579170","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0007286","count":2},{"id":"GO:1903045","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0000447","count":2}]},{"hash":"460527356189987941","title":"Nucleolar RNA processing and ribosome biogenesis","description":"This cluster centers on ribosome biogenesis and RNA processing in the nucleus/nucleolus, with terms for LSU rRNA maturation, preribosome/large subunit assembly, RNA splicing regulation, and NMD, along with RNA-templated transcription and ncRNA-mediated silencing, indicating a cohesive theme around nuclear RNA metabolism and ribosome assembly.","confidence":"High","size":24,"edges":5,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":3},{"id":"GO:0001172","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0000463","count":2},{"id":"GO:1902626","count":2}]},{"hash":"253670446923414744","title":"Mammary epithelial development and cell cycle control","description":"This cluster features mammary gland epithelial proliferation and differentiation signals (lactation, mammary gland epithelial cell proliferation, multi-ciliated epithelial differentiation) coupled with cell cycle transitions (G1/S, G2/M) and transcriptional regulation, pointing to a coordinated development program in mammary epithelium. Some GO terms appear ancillary (magnesium response, early viral transcription) but do not redefine the theme.","confidence":"Medium","size":24,"edges":11,"triangles":5,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000086","count":5},{"id":"GO:0032026","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0000082","count":5},{"id":"GO:1903251","count":4}]},{"hash":"641419675737134963","title":"Diverse Stress-Response Signaling","description":"The top GO terms point to regulatory signaling linked to stress responses across contexts: glucocorticoid receptor\u2013mediated signaling (hormonal stress response), cellular responses to dsRNA (immune/stress response), cadmium ion response (metal stress), plus broader regulation of protein folding and modification. While some terms are obsolete, the overall pattern suggests proteins involved in signaling and regulating cellular responses to diverse environmental and physiological challenges, rather than a single specific pathway. Therefore, a label like Diverse Stress-Response Signaling best captures the theme.","confidence":"Medium","size":24,"edges":41,"triangles":91,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2000324","count":12},{"id":"GO:0072189","count":12},{"id":"GO:0071360","count":11},{"id":"GO:1903646","count":11},{"id":"GO:0051348","count":11}]},{"hash":"779353262224633537","title":"Mitotic Cell Cycle and APC-Dependent Ubiquitination","description":"The cluster\u2019s top GO terms cluster around mitosis and cell-cycle control, especially mitotic cell cycle, APC-dependent proteolysis, and K11-linked ubiquitination, pointing to regulation of mitotic progression by ubiquitin signaling. While a few terms touch on development and immune response, the dominant signal is proteins involved in cell division and ubiquitin-mediated degradation.","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:2001162","count":5},{"id":"GO:0031145","count":5},{"id":"GO:0070979","count":5},{"id":"GO:0000278","count":5}]},{"hash":"920737158464872969","title":"Neuroimmune Thermogenic and Inflammatory Signaling","description":"The terms cluster around inflammatory and thermo-regulatory processes (pain, temperature response, diet-induced thermogenesis, prostaglandin signaling, xenobiotic response, macrophage chemotaxis) and include neural components (dopaminergic synaptic transmission) with some development-ish terms (heart development, visual learning), suggesting a shared theme of neuroimmune coordination of thermogenic and inflammatory responses, with neural signaling involved.","confidence":"Medium","size":24,"edges":194,"triangles":729,"max_degree":22,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":20},{"id":"GO:0071502","count":19},{"id":"GO:0002024","count":19},{"id":"GO:0071380","count":17},{"id":"GO:0010759","count":16}]},{"hash":"378611876161440270","title":"Dopaminergic signaling and drug response","description":"The cluster is dominated by GO terms tied to dopaminergic synaptic transmission and drug-related behavioral responses (morphine, cocaine), plus ERK signaling involvement and learning-associated processes. This pattern points to neural signaling and reward pathways modulated by addictive substances. Some terms (heart development, visual perception) seem less connected and may reflect broader annotations, but the main signal supports dopamine-mediated neurotransmission and drug response.","confidence":"Medium","size":24,"edges":3,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":24},{"id":"GO:0043278","count":24},{"id":"GO:0010759","count":24},{"id":"GO:0001963","count":24},{"id":"GO:0006468","count":24}]},{"hash":"858260459195140961","title":"Neuropeptide signaling in cardiovascular and inflammatory regulation","description":"This cluster is dominated by neuropeptide signaling (GO:0007218) and cardiovascular regulation terms (vasopressin effects, renin secretion, and vascular smooth muscle differentiation), alongside inflammatory signaling terms (IL-1\u03b2 and chemokine production). The combination suggests proteins involved in neuropeptide-mediated control of blood pressure and vascular function with concurrent modulation of immune/inflammatory processes.","confidence":"High","size":24,"edges":17,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":20},{"id":"GO:0032651","count":20},{"id":"GO:0007218","count":20},{"id":"GO:2000724","count":20},{"id":"GO:0090075","count":20}]},{"hash":"1788220427964109031","title":"Neuropeptide signaling and cardiovascular regulation","description":"This cluster centers on neuropeptide signaling and hormones that regulate cardiovascular function, with links to dopaminergic synaptic regulation and renin/vasopressin\u2013mediated blood pressure control. Immune signaling terms (chemokine and IL-1\u03b2 production) suggest additional cross-talk with inflammatory pathways, but the dominant theme is neuroendocrine signaling that modulates cardiovascular and related immune responses.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":24},{"id":"GO:0032651","count":24},{"id":"GO:0007218","count":24},{"id":"GO:2000724","count":24},{"id":"GO:0090075","count":24}]},{"hash":"342786012066253758","title":"Neuronal development and axon guidance","description":"The proteins are annotated with terms converging on nervous system development, commissural neuron axon guidance, and paranode localization, plus signaling pathways such as small GTPase-mediated signaling, ERK cascades, and Wnt signaling. This combination supports a cohesive theme of neuronal development and axon pathfinding, despite a few obsolete terms and minimal connectivity. Confidence: High","confidence":"","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:1900242","count":4},{"id":"GO:0002175","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0007264","count":4}]},{"hash":"820478144893295716","title":"Unknown","description":"The top GO terms are highly heterogeneous, spanning apoptosis (execution phase, extrinsic signaling), immune signaling (T cell homeostasis, TNF response), genetic processes (DNA integration), sensory perception (sound), and responses to drugs (cocaine, morphine). With no edges and no clear shared function among proteins, there isn\u2019t a single coherent theme to assign a confident label.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097194","count":3},{"id":"GO:0043029","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0042220","count":2}]},{"hash":"1310912786413484991","title":"Developmental and immune signaling","description":"The top GO terms span immune regulation (Th1 response, IL-23 production), immune cell chemotaxis (mast cells), and central developmental processes (axon guidance, Robo signaling, ossification, spermatid development). This suggests a cluster of proteins involved in signaling pathways that coordinate development with immune and neural cell behavior, hence a label around developmental and immune signaling. ","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046330","count":5},{"id":"GO:0071260","count":5},{"id":"GO:0032707","count":5},{"id":"GO:0042088","count":5},{"id":"GO:0035385","count":4}]},{"hash":"1936727184154352633","title":"ER stress response and mitochondrial apoptosis","description":"This cluster is driven by unfolded protein response, ER stress, and chaperone-related refolding terms, including response to unfolded protein, heat, and regulation of translation initiation in response to ER stress. The presence of mitochondrial cytochrome c release and apoptotic process terms links ER stress to mitochondrial-mediated apoptosis, suggesting ER-mitochondrial cross-talk as a core theme. Lipid transport/lipoprotein metabolism and endothelial activation terms are present but seem less central to the main signal.","confidence":"High","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006869","count":4},{"id":"GO:0042118","count":4},{"id":"GO:0042157","count":4},{"id":"GO:0070389","count":4},{"id":"GO:0006986","count":4}]},{"hash":"1863991871162247475","title":"Developmental morphogenesis regulators","description":"These proteins appear linked to diverse developmental processes and morphogenetic regulation across multiple tissues (hair, kidney, bone, teeth, gonadal/immune contexts), including negative regulation of ossification, osteoblast proliferation, and apoptotic signaling. This supports labeling as Developmental morphogenesis regulators.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031069","count":2},{"id":"GO:0001658","count":2},{"id":"GO:0030279","count":2},{"id":"GO:0033137","count":2},{"id":"GO:0033689","count":2}]},{"hash":"1530703106176372311","title":"Unknown","description":"This cluster's top GO terms span cardiac electrophysiology (ventricular and atrial action potentials), ion transport, proteolysis, adipose proliferation, immune regulation, host-symbiont interactions, and diverse developmental processes (nephrocyte diaphragm, axon guidance, salivary gland boundary). The diversity suggests no single cohesive function or pathway dominates the set, so a specific, representative label cannot be confidently assigned.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060307","count":4},{"id":"GO:0086014","count":4},{"id":"GO:0010765","count":4},{"id":"GO:0006508","count":4},{"id":"GO:0070352","count":4}]},{"hash":"712482198416089986","title":"Neuronal Synaptic Plasticity and Vocalization","description":"The cluster shows strong representation of GO terms tied to synaptic function and plasticity: chemical synaptic transmission; positive regulation of excitatory postsynaptic potential; long-term synaptic depression; dendritic spine morphogenesis; and regulation of synapse structural plasticity. It also includes behavioral terms such as social behavior, sensory perception of sound, and vocalization behavior, pointing to neural circuits governing communication and auditory processing. A single ERAD-related term appears as potential noise. Overall, the cluster centers on neuronal synapse dynamics and vocal/communication behaviors.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007268","count":2},{"id":"GO:1904378","count":2},{"id":"GO:0006355","count":2},{"id":"GO:2000463","count":2},{"id":"GO:0060292","count":2}]},{"hash":"1439406426108561844","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010587","count":2},{"id":"GO:0030260","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0039702","count":2},{"id":"GO:0015074","count":2}]},{"hash":"2032687777274919408","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045765","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0006898","count":3},{"id":"GO:0071392","count":3}]},{"hash":"1995319234128518672","title":"Inner ear morphogenesis and hearing","description":"The top GO terms are strongly skewed toward inner ear development and auditory function (inner ear receptor cell development, labyrinthine layer morphogenesis, sensory perception of sound, and related morphogenesis terms). While there are a few unrelated terms, the dominant signals point to proteins involved in ear formation and hearing processes, justifying a label centered on inner ear morphogenesis and auditory function.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0060670","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0007626","count":2}]},{"hash":"1944346582678855503","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0035914","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0010587","count":2}]},{"hash":"411009579110696786","title":"Antiviral innate immune response","description":"Based on the top GO terms, the cluster is enriched for innate antiviral defenses and dsRNA/interferon signaling (innate immune response, cellular response to dsRNA, cellular response to type I interferon, and defense response to virus), suggesting a core theme of antiviral defense. Some terms like photosynthesis and hormone signaling appear discordant, likely reflecting broad or multi-function proteins or annotation noise, but the dominant signal points to antiviral innate immunity.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0051301","count":10},{"id":"GO:0009938","count":9},{"id":"GO:0071360","count":9},{"id":"GO:0071357","count":9},{"id":"GO:0045087","count":9}]},{"hash":"548345033767062004","title":"Multicellular Development and Morphogenesis","description":"These terms cluster around multicellular development and tissue morphogenesis, including endothelial morphogenesis, sarcomere organization, and branchiomotor neuron axon guidance, indicating a developmental/morphogenic theme across tissues. Additional terms related to immune signaling and response to bacterial components suggest broader signaling roles, but the dominant pattern remains developmental and morphogenetic processes.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:1904753","count":2},{"id":"GO:0045214","count":2},{"id":"GO:1904706","count":2},{"id":"GO:0035234","count":2}]},{"hash":"1132849478918877651","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":216,"triangles":1226,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048026","count":6},{"id":"GO:0000398","count":5},{"id":"GO:0048701","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0071042","count":5}]},{"hash":"1260721702340714743","title":"Retroviral integration and DNA repair","description":"This cluster combines DNA metabolism (recombination, replication, base-excision repair) with retroviral life-cycle steps (RNA-templated DNA synthesis, DNA integration, proviral latency, and viral entry into the host nucleus), plus signals of RNAi pathway interaction, pointing to a theme of DNA maintenance linked to retroviral integration and latency.","confidence":"High","size":23,"edges":79,"triangles":77,"max_degree":20,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":12},{"id":"GO:0006260","count":9},{"id":"GO:0006284","count":8},{"id":"GO:0007568","count":7},{"id":"GO:0006278","count":7}]},{"hash":"1093018368119119700","title":"Unknown","description":"This cluster's terms cover nervous system signaling (GTPase activity regulation, membrane potential, pain perception, glutamatergic synaptic transmission, fear behavior) but also non-neuronal processes (cell wall/peptidoglycan catabolism, cytolysis, heart development, viral release). The diversity prevents a single coherent biological theme, so the label Unknown is most appropriate.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0042391","count":3},{"id":"GO:0051930","count":3},{"id":"GO:0051967","count":3},{"id":"GO:0019835","count":3}]},{"hash":"2121997834682319102","title":"Neural development and vesicle trafficking","description":"This cluster centers on neural development and vesicular transport: terms like regulation of synaptic vesicle endocytosis, forebrain radial glial differentiation, and formation of radial glial scaffolds point to neuronal development, while Golgi-to-plasma membrane transport and endocytic recycling reflect shared vesicle trafficking machinery. ","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1900242","count":5},{"id":"GO:0050885","count":4},{"id":"GO:0021943","count":4},{"id":"GO:0030521","count":4},{"id":"GO:0021861","count":4}]},{"hash":"1391697458405807394","title":"Developmental and DNA mobility proteins","description":"This cluster combines terms tied to multicellular development, spinal cord development, ossification, synapse assembly, cell adhesion, and apoptotic processes, indicating a general developmental and cellular organization theme. The presence of DNA transposition/integration terms suggests some transposon-derived components, but the dominant signal is development-related and cell-communication processes.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":4},{"id":"GO:0015074","count":3},{"id":"GO:0007275","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0006915","count":2}]},{"hash":"1222753049378341521","title":"Cartilage Condensation and Skeletal Morphogenesis","description":"The top GO terms point to cartilage condensation, skeletal system development, cranial skeleton morphogenesis, and collagen-mediated signaling, all indicating a shared role in development and formation of skeletal/cartilaginous structures. Some terms like sensory perception of pain or DNA replication appear but are less central to the core theme; overall, the cluster reflects cartilage and skeletal tissue formation during development, with related cell adhesion and organogenesis processes.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001502","count":7},{"id":"GO:0001501","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0038063","count":6},{"id":"GO:0007275","count":6}]},{"hash":"296033311007007427","title":"Integrin-ECM adhesion and ECM remodeling","description":"The cluster is dominated by GO terms related to cell adhesion to the extracellular matrix and integrin signaling, including calcium-independent cell-matrix adhesion, integrin-mediated signaling, and regulation of ECM assembly. Additional terms point to ECM-associated processes driving cell migration and tissue morphogenesis (dendrite regeneration, chondrocyte morphogenesis, endoderm differentiation) and extracellular movement (cellular extravasation). Immune-related terms (complement activation, coagulation) may intersect with ECM contexts but are likely secondary to the adhesion/matrix remodeling theme. Overall, these proteins likely function in integrin-ECM adhesion and ECM remodeling to support cell migration and tissue development.","confidence":"Medium","size":23,"edges":4,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007161","count":13},{"id":"GO:0007229","count":13},{"id":"GO:0031104","count":13},{"id":"GO:0007596","count":13},{"id":"GO:1901202","count":12}]},{"hash":"1523724195110845873","title":"Unknown","description":"The top GO terms are scattered across antiviral dsRNA response, photosynthesis, and various regulatory processes, with many obsolete entries, giving no clear single theme for the protein set. Therefore a specific, cohesive label isn\u2019t supported.","confidence":"","size":23,"edges":6,"triangles":0,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071360","count":20},{"id":"GO:1903646","count":20},{"id":"GO:0051348","count":20},{"id":"GO:1902391","count":20},{"id":"GO:2001162","count":20}]},{"hash":"1695054942102480366","title":"Neuroendocrine cardiovascular regulation","description":"This cluster centers on neuropeptide signaling and hormonal control of blood pressure and heart-related functions, as reflected by terms such as vasopressin-mediated regulation of blood pressure, renin secretion, and dopamine-related synaptic signaling. It also includes neuropeptide signaling pathways and regulation of immune mediators like IL-1 beta and chemokines, suggesting broader neuroimmune modulation. Together, these terms point to a cohesive theme of neuroendocrine control of cardiovascular physiology with ancillary immune signaling. Some terms are broad or obsolete, but the core signals repeatedly highlight vasopressin, renin, neuropeptides, and cardiovascular regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":23},{"id":"GO:0032651","count":23},{"id":"GO:0007218","count":23},{"id":"GO:2000724","count":23},{"id":"GO:0090075","count":23}]},{"hash":"1039230641931947549","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"The cluster shows multiple GO terms centered on actin filament assembly and dynamics (actin filament bundle assembly, barbed-end capping), regulation of GTPase activity, and cell migration/polarity (establishment of epithelial cell polarity, substrate-dependent cell migration). This points to a cohesive program of actin cytoskeleton remodeling driving cell movement and proper cell orientation, with signaling inputs via GTPases and related phosphorylation. Some reproductive-development terms appear, but the dominant theme is actin-based motility and polarity.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":3},{"id":"GO:0048235","count":2},{"id":"GO:0060065","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0090162","count":2}]},{"hash":"574888916313471216","title":"Neuro-immune Signaling Network","description":"The cluster mixes neural development signals (nervous system development, establishment of epithelial polarity) with immune signaling (T cell receptor pathway, TH1 response, IL-23 regulation) and multiple signaling cascades (JNK, ERK, Hedgehog/Smoothened, Roundabout). This suggests a cohesive network of signaling interactions that coordinate neural and immune functions, with a broader response to mechanical stimulus. ","confidence":"Medium","size":23,"edges":166,"triangles":513,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071260","count":9},{"id":"GO:0007399","count":8},{"id":"GO:0046330","count":8},{"id":"GO:0050852","count":7},{"id":"GO:0032707","count":7}]},{"hash":"736102817689675327","title":"Neuronal differentiation and synaptogenesis","description":"The cluster is dominated by GO terms related to neural development and synapse formation, including positive regulation of synapse assembly, axon guidance, pyramidal neuron differentiation, dendrite regeneration, and integrin-mediated signaling with cell adhesion. While there are some vascular-related terms present, the strongest and most frequent signals point to neuronal differentiation, growth, and synaptic organization. This suggests the proteins collectively function in neural development and synapse establishment.","confidence":"High","size":23,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0001558","count":2},{"id":"GO:2001027","count":2},{"id":"GO:0033564","count":2},{"id":"GO:0043652","count":2}]},{"hash":"881833953154526315","title":"Proviral DNA Integration and Latency","description":"This cluster is dominated by terms tied to viral genome integration, recombination, and establishment of proviral latency, along with entry of viral particles into host cells and nuclei. The inclusion of DNA transposition and related DNA processing terms, plus host response and xenobiotic stress terms, supports a cohesive theme around retroviral-like genome integration and its cellular context.","confidence":"High","size":23,"edges":33,"triangles":8,"max_degree":11,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":7},{"id":"GO:0006310","count":6},{"id":"GO:0075713","count":6},{"id":"GO:0075732","count":6},{"id":"GO:0039651","count":6}]},{"hash":"1610412387551523223","title":"Proviral integration and transposon activity in host","description":"This cluster is driven by GO terms for DNA integration, DNA transposition, proviral latency, and viral entry into the host nucleus, suggesting a core theme of viral/proviral dynamics and transposable elements shaping host cell processes. Additional terms about defense against virus and symbiont interactions support a broader host-virus/symbiont context, but the central thread remains proviral integration and transposition. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0015074","count":7},{"id":"GO:0075713","count":7},{"id":"GO:0046718","count":6},{"id":"GO:0039651","count":5},{"id":"GO:0006313","count":5}]},{"hash":"1996226586083119344","title":"Bacterial lipid metabolism and secondary metabolite biosynthesis","description":"This cluster centers on fatty acid biosynthesis and transport (long-chain and medium-chain fatty acids), lipoteichoic acid biosynthesis, and broader lipid-related metabolism, complemented by nonribosomal peptide biosynthesis and even bioluminescence, all of which are characteristic of bacterial secondary metabolism and lipid pathways. The presence of pyruvate fermentation to acetate and bile acid-related metabolism further supports a microbial metabolic theme. The seed coat development term appears as an outlier, likely noise. Overall, the data point to a bacterial lipid metabolism and secondary metabolite biosynthesis focus.","confidence":"Medium","size":23,"edges":128,"triangles":346,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0043041","count":7},{"id":"GO:0006633","count":6},{"id":"GO:0070395","count":6},{"id":"GO:0008206","count":5}]},{"hash":"1247986019238981224","title":"RNA Pol II Transcription Regulation","description":"The dominant GO terms point to transcription by RNA polymerase II and DNA-templated transcription, including both positive and negative regulation of Pol II transcription, indicating the cluster is enriched for factors governing Pol II-driven gene expression. While there are additional terms touching on immune and metabolic processes (MHC II biosynthesis, IL-4 response, glucose homeostasis, ovulation, vascular wound healing), these can be linked as contexts where transcriptional regulation is pivotal. Overall, the core theme appears to be RNA Pol II\u2013mediated transcription regulation, with ancillary roles in immune and endocrine-related pathways.","confidence":"Medium","size":23,"edges":201,"triangles":898,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0006351","count":7},{"id":"GO:0000122","count":6},{"id":"GO:0035470","count":6},{"id":"GO:0036091","count":6}]},{"hash":"373005880534795684","title":"Folate metabolism and mitochondrial tRNA aminoacylation","description":"The top GO terms cluster around formate metabolism, tetrahydrofolate interconversion, and folic acid biosynthesis/catabolism, indicating a core folate metabolism theme. Several terms describe mitochondrial tRNA aminoacylation (valine, tyrosyl, tryptophanyl), suggesting a link to mitochondrial translation. Angiogenesis/vasculogenesis are present but less central, with gluconeogenesis adding a metabolic context. Overall, the cluster centers on folate-related metabolism with a mitochondrial translation component.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015942","count":5},{"id":"GO:0035999","count":5},{"id":"GO:0009396","count":5},{"id":"GO:0046657","count":5},{"id":"GO:0001525","count":3}]},{"hash":"1979094832495762466","title":"Fibrinolysis and Innate Immune Activation","description":"The top GO terms cluster around extracellular proteolysis and innate immune processes, including plasminogen activation and fibrinolysis, complement activation via the lectin pathway, and response to lipopolysaccharide, along with related vascular remodeling and cell adhesion terms. A few terms (e.g., midbrain development) appear less coherent with the dominant theme, likely annotation noise. Overall, the set suggests a shared function in proteolysis-linked immune/coagulation pathways, justifying this label.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":6},{"id":"GO:0055114","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0042730","count":4},{"id":"GO:0045766","count":4}]},{"hash":"438690554069598614","title":"Multitissue Development and Morphogenesis","description":"The GO terms cluster around developmental programs across several tissues (vascular, neural, lung, cartilage, muscle) and related secretory/assembly processes, suggesting a role in organogenesis and tissue morphogenesis.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0001569","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0030324","count":2},{"id":"GO:0032781","count":2}]},{"hash":"1014980202866154453","title":"Retrotransposons and Proviral Integration","description":"The terms cluster around DNA mobility and genome integration, including DNA integration, retrotransposition, DNA transposition, RNA-templated DNA synthesis, and proviral latency. Additional terms on viral entry and host-pathogen interactions (symbiont-related processes) support a cohesive theme of mobile genetic elements and proviral integration.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":8},{"id":"GO:0075713","count":6},{"id":"GO:0075732","count":6},{"id":"GO:0039651","count":6},{"id":"GO:0046718","count":6}]},{"hash":"620090200583446430","title":"Neural development and synaptic organization","description":"This cluster shows multiple neural-focused terms, including sympathetic ganglion development, commissural neuron axon guidance, vestibulocochlear nerve structure, and regulation of synaptic vesicle endocytosis, suggesting a central theme around nervous system development and synaptic function. Some terms like DNA integration, pollen recognition, and macrophage chemotaxis are less related, but the neural signals dominate the top GO terms.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902042","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0061549","count":1},{"id":"GO:0071679","count":1},{"id":"GO:0010758","count":1}]},{"hash":"1016175042817470414","title":"Innate Immune Signaling and Inflammation","description":"The cluster is enriched for terms tied to microbe sensing and inflammatory pathways: response to peptidoglycan and molecule of fungal origin, MyD88-dependent Toll-like receptor signaling, NF-kappaB transcription factor activity, inflammatory response, and necroptotic signaling. Together these suggest a group of proteins functioning in innate immune recognition and downstream inflammatory signaling.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051092","count":8},{"id":"GO:0032494","count":7},{"id":"GO:0032747","count":7},{"id":"GO:0002238","count":7},{"id":"GO:0006954","count":7}]},{"hash":"806913881915009897","title":"Endocytosis and intracellular trafficking regulation","description":"Dominant GO terms point to endocytic and trafficking processes (ubiquitin-dependent endocytosis, endocytic recycling, retrograde transport from endosome to Golgi) and regulatory events (positive regulation of transcription by RNA polymerase II, protein desumoylation). While a few terms (DNA integration, ECM disassembly, cytolysis) are more divergent, the strongest shared theme among the proteins is involvement in endocytosis and intracellular trafficking, with accompanying regulatory modifications.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032226","count":2},{"id":"GO:0042147","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0090305","count":2},{"id":"GO:0090091","count":2}]},{"hash":"1168816751161757871","title":"Unknown","description":"The 23-protein cluster includes terms spanning neuronal development (neuron projection development, brain development), cytoskeleton (actin filament depolymerization), ribosome biogenesis and RNA methylation, and viral translation, with no single cohesive function emerging. The lack of interactions (edges/triangles) and presence of obsolete terms further prevent a clear, unified biological theme. Therefore, Unknown.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061087","count":3},{"id":"GO:0035948","count":3},{"id":"GO:0030042","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0007420","count":3}]},{"hash":"2267499312546071864","title":"Ribosome biogenesis and rRNA maturation","description":"The cluster is enriched for GO terms describing maturation of SSU/LSU rRNA and ribosomal large subunit biogenesis, including maturation of 5.8S rRNA, which strongly points to nucleolar ribosome assembly and RNA processing. The presence of mRNA splicing via spliceosome suggests broader RNA processing functions, consistent with a nucleus/nucleolus localization. Some cell-cycle related terms indicate these processes are linked to proliferative states where ribosome production is upregulated. Overall, the common theme is ribosome biogenesis and rRNA maturation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042273","count":7},{"id":"GO:0000466","count":7},{"id":"GO:0000463","count":7},{"id":"GO:0000462","count":7},{"id":"GO:0000398","count":7}]},{"hash":"1906571378499719068","title":"Neuronal Pain Signaling and Opioid Response","description":"This cluster centers on pain signaling and opioid response, with strong GO terms for sensory perception of pain, regulation of pain, neuropeptide signaling, GPCR signaling, and response to morphine. The presence of electron transport chain terms likely reflects general neuronal metabolism, but the dominant theme is nociception and opioid modulation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":18},{"id":"GO:0045777","count":17},{"id":"GO:0022900","count":17},{"id":"GO:0010579","count":17},{"id":"GO:0007218","count":17}]},{"hash":"1812466409676194928","title":"Neuropeptide Signaling and Blood Pressure Regulation","description":"The cluster is enriched for neuropeptide signaling and vascular/cardiovascular regulation, including vasopressin-mediated blood pressure control, renin secretion, and dopaminergic/synaptic signaling, with related muscle relaxation; together these indicate a cohesive neuroendocrine control of cardiovascular function, despite some immune-related terms present.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":21},{"id":"GO:0032651","count":21},{"id":"GO:0007218","count":21},{"id":"GO:2000724","count":21},{"id":"GO:0090075","count":21}]},{"hash":"1802885856439316400","title":"Rho-GTPase\u2013driven vertebrate morphogenesis","description":"This cluster centers on Rho GTPase signaling and actin remodeling (regulation of Rho signaling, positive regulation of GTPase activity, filopodium assembly) with developmental GO terms for cochlea/otolith morphogenesis, heart development, and sensory perception of sound, indicating a theme of cytoskeletal dynamics guiding vertebrate organ morphogenesis, especially in the ear and related functions.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0007605","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0032474","count":2}]},{"hash":"380355771037732457","title":"GPCR signaling and ERK-driven vascular-neural regulation","description":"The top GO terms center on GPCR processes (internalization, GTPase activity, Rho signaling) and the ERK1/2 cascade, with associated cardiovascular and neural effects (heart development, vasoconstriction, prostaglandin response, dopamine/morphine responses). This suggests a cohesive GPCR signaling module influencing heart/vascular function and neural signaling; an outlier term about viral release is likely incidental. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0019076","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0002031","count":3}]},{"hash":"1649621563162713433","title":"Ubiquitin-Dependent Innate Immune Signaling","description":"The prevalent GO terms point to ubiquitination processes (polyubiquitination, autoubiquitination, K63-linked ubiquitination) coupled with innate immune activities (innate immune response, defense against virus, NF-kappaB/TNF signaling). This suggests a cluster centered on ubiquitin-mediated regulation of antiviral immune signaling, with a secondary nod to circadian-related regulation.  ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":17},{"id":"GO:0045087","count":10},{"id":"GO:0000209","count":8},{"id":"GO:0042752","count":8},{"id":"GO:0070534","count":8}]},{"hash":"1778753533902628106","title":"Proteoglycan biosynthesis and ECM glycosylation","description":"The top terms are dominated by proteoglycan biosynthesis (keratan sulfate and chondroitin sulfate) and protein glycosylation (O- and N-linked), pointing to extracellular matrix components and glycoprotein construction. Additional terms related to cartilage development (chondrocyte development) and tissue formation (heart trabecula formation) support a broader developmental/structural theme, while some outliers (myelination, magnesium transport, IL-8 regulation) may reflect broader or indirect associations. Overall, a cohesive label focusing on ECM proteoglycan biosynthesis and glycosylation is appropriate.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035269","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0030206","count":2},{"id":"GO:0030245","count":2},{"id":"GO:0018146","count":2}]},{"hash":"400179064991318367","title":"Viral integration and proviral latency","description":"The top GO terms strongly point to viral genome manipulation: DNA integration, establishment of integrated proviral latency, and viral penetration into the host nucleus, complemented by DNA recombination, replication, and transposition. This suggests a cluster centered on proviral integration and latency mechanisms, with additional signals of virus\u2013host interaction and genome remodeling; the unrelated ossification term appears as noise. I labeled it as viral genome integration and proviral latency to reflect the dominant theme.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0075713","count":5},{"id":"GO:0075732","count":5},{"id":"GO:0039651","count":5},{"id":"GO:0046718","count":5}]},{"hash":"959574504092343896","title":"Pain and Thermoregulation GPCR-Neuropeptide Signaling","description":"These terms cluster around neural signaling of pain, temperature response, and thermogenesis, with GPCR and neuropeptide signaling and calcium release as central mechanisms. The combination suggests a module where pain perception is tied to thermoregulatory and metabolic responses, potentially involving vascular regulation and inflammatory signaling, reflected by terms related to blood pressure regulation and IL-1 beta production. The electron transport chain term fits the energy demands of these processes, supporting the overall theme of neural control of pain and heat/metabolic regulation via GPCR\u2013neuropeptide pathways.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":8},{"id":"GO:0051209","count":7},{"id":"GO:0071502","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0010579","count":7}]},{"hash":"907150493327325418","title":"Post-transcriptional RNA processing and translation control","description":"It includes GO terms for splicing, polyadenylation, mRNA export, and mRNA stability regulation, plus translation initiation/reinitiation and RNA silencing mechanisms. The common theme is post-transcriptional regulation of gene expression, spanning RNA processing and translational control.","confidence":"High","size":22,"edges":52,"triangles":50,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":8},{"id":"GO:0045292","count":7},{"id":"GO:0006378","count":7},{"id":"GO:0001731","count":7},{"id":"GO:0002188","count":7}]},{"hash":"675472942479152252","title":"RNA processing and viral translation","description":"The cluster centers on RNA metabolism and translation processes: ribosomal biogenesis, mRNA splicing, ncRNA-mediated gene silencing, and mRNA export, together with viral genome replication and IRES-dependent translation. While DNA replication and vesicle transport occasionally appear, the common theme is RNA processing and protein synthesis with viral interaction points, suggesting a cohesive function around RNA handling and viral translation mechanisms.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0042273","count":4},{"id":"GO:0048026","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0006888","count":3}]},{"hash":"2128883107571222490","title":"Proviral integration and viral translation regulation","description":"The top GO terms cluster around proviral DNA integration and establishment of integrated proviral latency, with strongly represented viral translation initiation/termination, including IRES-dependent initiation and translation reinitiation, plus spliceosome-mediated mRNA processing. This suggests a theme of host factors involved in proviral life-cycle steps and viral gene expression control, with RNA processing components potentially co-opted during viral infection. Confidence in this label is Medium.","confidence":"Medium","size":22,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":4},{"id":"GO:0048026","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0075713","count":4}]},{"hash":"1762677931935377863","title":"Transcription Regulation and RNA Processing","description":"This cluster is dominated by GO terms tied to DNA-templated transcription and transcription regulation (DNA-templated transcription, transcription antitermination, negative regulation of termination of DNA-templated transcription) along with RNA maturation steps (pre-miRNA processing, miRNA catabolic process). The combination suggests a coherent group of proteins involved in transcription control and RNA processing/miRNA biogenesis. A few less central terms (cell cycle, lipopolysaccharide biosynthetic process, kidney development) appear but are outliers relative to the main theme. Confidence: High","confidence":"","size":22,"edges":61,"triangles":70,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0070584","count":2},{"id":"GO:0009103","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0010587","count":1},{"id":"GO:0031054","count":1}]},{"hash":"1926986469397090550","title":"Unknown","description":"The cluster shows a mix of functions: DNA transposition/integration, ER protein folding, autophagosome assembly, endothelial proliferation, and several aromatic compound catabolic pathways. There is no single dominant biological process linking these terms, and the lack of edges suggests the proteins are not co-regulated in a common pathway. Therefore a cohesive, specific label cannot be assigned; Unknown is most appropriate.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":1},{"id":"GO:0001935","count":1},{"id":"GO:0034975","count":1},{"id":"GO:0000045","count":1},{"id":"GO:0015074","count":1}]},{"hash":"286905219862236321","title":"Retroviral integration and proviral latency","description":"GO terms cluster around retroviral processes: DNA replication, DNA integration, RNA-templated DNA synthesis, and DNA recombination, with explicit mentions of proviral latency establishment and viral entry into the host nucleus, plus host\u2013virus interaction terms such as modulation of siRNA processing and virus-induced apoptosis. This combination strongly points to components involved in the retroviral life cycle and proviral maintenance rather than general genomic maintenance, hence a label focusing on proviral integration and latency is appropriate.","confidence":"High","size":22,"edges":226,"triangles":1445,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":11},{"id":"GO:0075713","count":9},{"id":"GO:0015074","count":9},{"id":"GO:0006310","count":9},{"id":"GO:0046718","count":9}]},{"hash":"843105311498877160","title":"Proteolysis-Driven Tissue Remodeling in Development","description":"GO terms point to proteolysis (plasminogen activation, fibrinolysis), tissue remodeling (biomineral tissue development, angiogenesis) and immune activity (complement), with additional neural development cues (synaptic vesicle endocytosis, neuromuscular balance), suggesting a core theme of proteolytic remodeling during development affecting tissues and vessels, with ancillary neural and immune roles.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035641","count":4},{"id":"GO:0035264","count":4},{"id":"GO:0001867","count":3},{"id":"GO:0042730","count":3},{"id":"GO:0045766","count":3}]},{"hash":"2138314267918409562","title":"Neural crest\u2013axon guidance and craniofacial morphogenesis","description":"The cluster shows strong representation of axon guidance terms (semaphorin-plexin signaling, neuronal projection guidance, axonal fasciculation) and neural crest\u2013driven craniofacial development (ventral trunk neural crest migration, embryonic cranial skeleton morphogenesis, trigeminal nerve organization), with heart development suggesting neural crest contributions to cardiac structures as a related theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0097491","count":8},{"id":"GO:0021785","count":8},{"id":"GO:1902287","count":8},{"id":"GO:0021637","count":8},{"id":"GO:0036486","count":8}]},{"hash":"1817339810309465473","title":"Neural crest migration and axon guidance","description":"The GO terms converge on neural development, including ventral trunk neural crest cell migration, various axon guidance pathways (semaphorin-plexin), and organization/localization at paranodal/juxtaparanodal regions, plus neuron projection guidance, indicating a cohesive role in neural development and wiring.","confidence":"High","size":22,"edges":3,"triangles":0,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0036486","count":7},{"id":"GO:0030913","count":7},{"id":"GO:1902287","count":7},{"id":"GO:1900242","count":7},{"id":"GO:0071205","count":7}]},{"hash":"1795231152100342255","title":"Cardiac morphogenesis and epithelial polarity","description":"This cluster\u2019s top GO terms center on heart development (cardiac right atrium morphogenesis, Notch signaling in regulation of secondary heart field cardioblast proliferation) and epithelial cell polarity establishment, with supporting terms like cell migration. Together, they point to a cohesive theme of cardiac tissue organization and development, with mRNA processing and ubiquitination acting as broader cellular processes without redefining the core function.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":4},{"id":"GO:0035994","count":3},{"id":"GO:0003213","count":3},{"id":"GO:0090162","count":3},{"id":"GO:0016567","count":3}]},{"hash":"1689784949624736749","title":"Retrotransposons and proviral integration","description":"The GO terms cluster around DNA transposition, DNA integration, and retrotransposition, along with establishment of integrated proviral latency and viral penetration into the host nucleus, pointing to a shared theme of mobile genetic elements and host\u2013virus interactions. This pattern suggests the proteins are involved in genetic mobility and proviral maintenance within host cells, with a few peripheral terms appearing as noise. Overall, the dominant signal is coherent and representative of transposon/viral integration functions.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":5},{"id":"GO:0075713","count":5},{"id":"GO:0015074","count":5},{"id":"GO:0046718","count":5},{"id":"GO:0075732","count":4}]},{"hash":"1960910636177155000","title":"Developmental Transcription Regulation","description":"Top GO terms indicate a strong emphasis on transcription by RNA polymerase II and DNA-templated transcription, suggesting these proteins act as transcriptional regulators. The accompanying developmental terms (endocrine pancreas development, brain segmentation, rhombomere development, bronchiole development) point to roles in organogenesis and tissue patterning, supporting a cohesive theme of transcriptional control during development. Immune signaling terms (IL-4 response, MHC class II biosynthesis) may reflect broader regulatory functions or cross-talk, but the dominant signal remains developmental transcriptional regulation.","confidence":"High","size":22,"edges":228,"triangles":1483,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":15},{"id":"GO:0006351","count":9},{"id":"GO:0031018","count":9},{"id":"GO:0035470","count":8},{"id":"GO:0071353","count":8}]},{"hash":"1854253320019155461","title":"Oxidative stress and xenobiotic response","description":"Based on the prominent GO terms for cellular oxidant detoxification, response to xenobiotic stimulus, and redox-related processes, the cluster appears to comprise proteins involved in managing oxidative stress and detoxifying xenobiotics. Additional terms for hypoxia and unfolded protein response reinforce a general stress-response/metabolic adjustment theme; a lone mitotic cell cycle term is a weaker outlier and does not strongly redefine the overall theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0098869","count":4},{"id":"GO:0010288","count":4},{"id":"GO:0042493","count":3},{"id":"GO:0001666","count":3},{"id":"GO:0055114","count":3}]},{"hash":"91964764872405104","title":"Blood coagulation and cell adhesion","description":"The top GO terms show strong representation of coagulation, plasminogen activation, and fibrinolysis, indicating a core theme around blood coagulation and its regulation. Additional terms point to cell\u2013cell adhesion, receptor clustering, and synapse assembly, suggesting these proteins may participate in cellular interfaces and signaling beyond coagulation. Notch signaling regulation and developmental terms appear as ancillary hints, but the dominant signal is coagulation/fibrinolysis with adhesion-related processes.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":14},{"id":"GO:0045746","count":14},{"id":"GO:0051919","count":13},{"id":"GO:0007596","count":13},{"id":"GO:0031639","count":13}]},{"hash":"2279068263361055121","title":"Neural crest migration and axon guidance","description":"The dominant GO terms point to neural development, especially neural crest cell migration, sympathetic neuron projection extension/guidance, axonal fasciculation, and semaphorin-plexin signaling. These terms together indicate a core theme of neuron pathfinding and neural crest\u2013derived migration, with only a secondary hint of immune-related processes. ","confidence":"High","size":22,"edges":92,"triangles":198,"max_degree":16,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042102","count":6},{"id":"GO:0031295","count":5},{"id":"GO:0001501","count":4},{"id":"GO:0097490","count":4},{"id":"GO:0097491","count":4}]},{"hash":"313386271296869024","title":"Monoaminergic Neuron Axon Guidance and Synapse Assembly","description":"The top GO terms point to development of monoaminergic neural circuits, with emphasis on synapse assembly and axon guidance in serotonergic and dopaminergic neurons. This suggests a cohesive function in wiring monoaminergic systems. Peripheral signals like inflammatory and lipopolysaccharide responses may reflect context-dependent neuroimmune interactions, but the core theme remains neural development and synaptic organization.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007416","count":3},{"id":"GO:0036515","count":3},{"id":"GO:0036514","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0071504","count":3}]},{"hash":"794067564674981940","title":"Viral integration and host-entry modules","description":"This cluster is dominated by GO terms related to viral life-cycle steps, including DNA integration, integrated proviral latency, and viral entry into the host nucleus, along with related host interaction processes (e.g., regulation of proteasomal degradation and symbiont-induced host responses). While a couple terms touch on development, the strongest signals point to viral genome integration and entry, suggesting these proteins function together in viral infection and host manipulation pathways.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032435","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0039651","count":2}]},{"hash":"2188282697515102175","title":"Developmental signaling and morphogenesis","description":"The terms point to broad developmental and morphogenetic processes across tissues (skeletal, heart, salivary gland) with neuronal development (dendrite development) and axon guidance (Roundabout signaling), supported by intracellular signaling (GTPase regulation, STAT phosphorylation) and vesicular transport (endosome-to-Golgi). This suggests a cluster of proteins involved in developmental signaling and tissue morphogenesis.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":2},{"id":"GO:0016358","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0034498","count":2},{"id":"GO:0035385","count":2}]},{"hash":"990460271577742919","title":"Unknown","description":"The GO terms include development (multicellular organism development, nervous system development), muscle structure (sarcomere organization), signaling (positive regulation of ERK1/ERK2 cascade), and protein turnover (negative regulation of protein ubiquitination), as well as meiotic DNA recombination and repair terms. This mix spans developmental, structural, signaling, and meiotic/DNA repair processes, with no single cohesive function linking them all, so a clear, representative label is not apparent.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0007399","count":2},{"id":"GO:1900477","count":2}]},{"hash":"817540092649479579","title":"Epithelial signaling, differentiation, and stress responses","description":"The cluster shows a mix of signaling and response terms centered on epithelial biology: keratinocyte differentiation, Hippo and Wnt signaling, apoptosis, and cellular responses to inflammatory stimuli (LPS, GM-CSF). This suggests a coherent theme around growth control, differentiation, and stress/inflammatory signaling in epithelial cells, with potassium transport likely less central. Overall, a moderate-to-strong representation of signaling and response pathways supports labeling as epithelial signaling and stress/differentiation cluster.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006915","count":6},{"id":"GO:0097011","count":5},{"id":"GO:0060044","count":5},{"id":"GO:0071222","count":5},{"id":"GO:0035329","count":5}]},{"hash":"507894990268339671","title":"Muscle and Heart Development with Transcription Regulation","description":"The cluster centers on muscle differentiation and heart development (skeletal muscle differentiation, heart development) and is enriched for transcriptional regulation terms (DNA-templated transcription, RNA polymerase II transcription, and its regulation). Additional hints of chromatin modification (histone methylation) and DNA damage response regulation suggest a chromatin-level control of gene expression in a muscle/heart developmental program, with innate immunity terms present but less central. This combination points to a developmental transcription program governing muscle and cardiac lineage specification.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010452","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0035914","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0006469","count":3}]},{"hash":"1301665849287074700","title":"Diverse Membrane Transporters","description":"The cluster is dominated by transmembrane transport GO terms, including nitrite/nitrate and sodium transport, sugar and xenobiotic transport, and a vesicular neurotransmitter loading term, suggesting a group of membrane transporter proteins with broad substrate specificity (including neurotransmitter packaging). ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":5},{"id":"GO:0015707","count":5},{"id":"GO:0015706","count":5},{"id":"GO:0042128","count":5},{"id":"GO:0035725","count":5}]},{"hash":"626829174690580894","title":"Neuroendocrine control of pain and cardiovascular function","description":"The cluster is dominated by neuropeptide signaling, dopamine uptake regulation, vasopressin-related blood pressure control, and muscle relaxation, alongside temperature- and energy-related terms (diet-induced thermogenesis, cellular response to temperature). This points to a cohesive theme of neuroendocrine signaling coordinating pain perception, autonomic cardiovascular regulation, and energy/temperature responses. Confidence: High","confidence":"","size":22,"edges":18,"triangles":0,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":17},{"id":"GO:0002024","count":17},{"id":"GO:0019233","count":17},{"id":"GO:0043950","count":16},{"id":"GO:0032651","count":16}]},{"hash":"1866858328597166277","title":"Diverse substrate membrane transporters","description":"This cluster shows GO terms for transmembrane transport of a wide range of substrates (ions, sugars, nitrite/nitrate, xenobiotics, and neurotransmitter packaging), indicating a common function in moving compounds across membranes rather than a single pathway.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0098700","count":3},{"id":"GO:0015707","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0042128","count":3}]},{"hash":"1194196511662628886","title":"Heart and craniofacial skeletal development","description":"Based on the recurring GO terms, this cluster centers on vertebrate organogenesis and skeletal/craniofacial development, including heart formation, facial and skull bone morphogenesis, intramembranous ossification, and ear-related structures (otolith, sound perception). ERK signaling and wound healing themes further support a developmental and tissue-remodeling role.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0032474","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0060346","count":2},{"id":"GO:0035987","count":2}]},{"hash":"1820433857006119707","title":"Unknown","description":"The top terms are highly heterogeneous (DNA integration/transposition alongside endothelial, translation, immune/homeostasis, and growth-factor\u2013related processes), and there are no edges or interactions connecting the proteins (edges 0, triangles 0, max degree 0). This suggests no cohesive shared function to define a meaningful cluster label.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0006313","count":1},{"id":"GO:0001935","count":1},{"id":"GO:1904246","count":1},{"id":"GO:1904628","count":1}]},{"hash":"2233190179452198450","title":"Neuroendocrine Thermogenesis and Cardiovascular Signaling","description":"The cluster is enriched for temperature response, thermogenesis, GPCR/cAMP signaling, neuropeptide signaling, and cardiovascular regulation (blood pressure and vascular smooth muscle differentiation), suggesting a linked neuroendocrine control of energy metabolism and cardiovascular function.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":19},{"id":"GO:0010579","count":19},{"id":"GO:0045777","count":19},{"id":"GO:0022900","count":19},{"id":"GO:0002024","count":19}]},{"hash":"420098810087970564","title":"Neuronal development and migration regulation","description":"The top GO terms are dominated by neural-related processes: negative regulation of neuron death, tangential migration from the subventricular zone to the olfactory bulb, and regulation of branching morphogenesis of a nerve, suggesting the proteins function together in neural development and neuronal migration. Some terms appear unrelated (e.g., meristem structural organization) which may reflect annotation noise or cross-tunctional roles, but the neural signal is the strongest.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901215","count":5},{"id":"GO:0009933","count":4},{"id":"GO:1902499","count":3},{"id":"GO:2000172","count":3},{"id":"GO:1903206","count":3}]},{"hash":"1268015415020372535","title":"Innate immune signaling and ubiquitin regulation","description":"This cluster centers on innate immune response and antiviral defense, with strong links to ubiquitin-mediated protein turnover and signaling (K63-linked ubiquitination and TNF pathways), indicating a cohesive immune-regulatory theme; the nervous system development term appears as a secondary annotation rather than the primary function.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":8},{"id":"GO:0042787","count":6},{"id":"GO:0051607","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0051092","count":5}]},{"hash":"1168503334580625021","title":"Ubiquitin-Proteasome Regulation of Innate Immunity","description":"The cluster is enriched for ubiquitination and proteasomal degradation processes (SCF-dependent ubiquitin-protein catabolic pathways) alongside innate-immune and inflammatory signals (innate immune response, TLR4 signaling, defense against Gram-positive bacteria, pyroptotic inflammatory response) and apoptosis. This pattern suggests a cohesive role where ubiquitin-proteasome\u2013mediated protein turnover modulates innate immune signaling and inflammatory cell death, with mitotic spindle assembly appearing as a potential collateral connection to cell-cycle\u2013related ubiquitination rather than the core function. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090307","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0031146","count":5},{"id":"GO:0070269","count":5},{"id":"GO:1990001","count":5}]},{"hash":"1638312280287765753","title":"Inflammation-driven adhesion and migration","description":"Inflammatory cues (TNF, IL-1) and integrin signaling appear among the top terms, together with actin filament organization, epithelial polarity, and cell migration. This suggests a theme where inflammatory signals coordinate adhesion, cytoskeletal remodeling, and movement, with supporting roles for gene expression and vesicle trafficking. Negative regulation of myelination also hints at broader nervous-system\u2013related modulation but is less central to the core adhesion/migration profile.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016191","count":2},{"id":"GO:0031642","count":2},{"id":"GO:0051044","count":2},{"id":"GO:0071356","count":2},{"id":"GO:0007229","count":2}]},{"hash":"751003268098707490","title":"Diverse membrane transporters","description":"The GO terms are dominated by transmembrane transport activities for many substrates (nitrite, nitrate, sugars, sodium, xenobiotics) and a vesicular neurotransmitter loading term, suggesting a cluster of diverse membrane transport proteins rather than a single pathway.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":3},{"id":"GO:0015707","count":3},{"id":"GO:0015706","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0035725","count":3}]},{"hash":"428137002287000923","title":"Cyclic Nucleotide Signaling (cAMP/cGMP)","description":"The cluster is dominated by GO terms related to cyclic nucleotide signaling and signal transduction, including receptor guanylyl cyclase signaling, cGMP and cAMP biosynthesis, and intracellular signaling pathways. Additional terms hint at environmental sensing (hypoxia, blue light) and downstream transcriptional regulation, suggesting a coherent theme of cyclic nucleotide\u2013mediated signaling with transcriptional responses.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0070483","count":4},{"id":"GO:0007168","count":4},{"id":"GO:0030828","count":4},{"id":"GO:1900194","count":4}]},{"hash":"594303887380146500","title":"Developmental morphogenesis and adhesion signaling","description":"The top GO terms point to signaling and processes that drive tissue morphogenesis and cell interactions, including hepatocyte growth factor receptor signaling (MET), branching morphogenesis, myoblast and trophoblast differentiation, regulation of embryonic cell shape, and cell\u2013cell adhesion. Together, these terms suggest a common theme of developmental morphogenesis governed by epithelial\u2013mesenchymal interactions and adhesion dynamics, rather than a single linear pathway.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0048012","count":4},{"id":"GO:0007155","count":4},{"id":"GO:0060665","count":4},{"id":"GO:0033137","count":3},{"id":"GO:0033601","count":3}]},{"hash":"301961518612659004","title":"Photoreceptor calcium signaling","description":"The top GO terms center on calcium ion flux (release into cytosol, import across the membrane, and regulation of release) and phototransduction, which together strongly point to calcium dynamics in retinal photoreceptor cells. While a few terms touch on development or other ion transport, the dominant theme is calcium signaling tied to light-response pathways in photoreceptors.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":5},{"id":"GO:0007603","count":5},{"id":"GO:0051281","count":5},{"id":"GO:0006828","count":5},{"id":"GO:0098703","count":5}]},{"hash":"34051309443453090","title":"Lymphocyte Activation Signaling","description":"The top GO terms are dominated by adaptive immune signaling: T cell receptor signaling, B cell affinity maturation, interleukin-2 production, and Fc receptor\u2013mediated signaling. Additional terms like DNA replication and cholesterol biosynthesis fit the proliferative and membrane-building needs of activated lymphocytes, while one outlier (visual learning) may be annotation noise. Overall, the cluster appears to represent immune receptor signaling and lymphocyte activation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008542","count":3},{"id":"GO:0006695","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0050852","count":2}]},{"hash":"216666848951750139","title":"Transcription and Cell Fate Regulatory Proteins","description":"The terms point to regulation-centric roles: negative regulation of transcription by RNA Pol II, control of the cell cycle, apoptosis/necroptosis regulation, TLR signaling regulation, protein ubiquitination, and protein processing (deglutathionylation). Together they imply a cluster of regulatory proteins that modulate gene expression and cell fate decisions, rather than enzymes performing a single metabolic task. Some terms (DNA transposition, G-protein complex assembly) are broader but can tie into regulatory networks.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0071157","count":1},{"id":"GO:0034121","count":1},{"id":"GO:0000209","count":1}]},{"hash":"1803757848131007537","title":"Ubiquitin-Dependent Innate Immunity","description":"This cluster is enriched in ubiquitination-related processes (ubiquitin-dependent protein catabolic process; protein ubiquitination) together with innate immune and antiviral defense terms (innate immune response; defense response to virus) and TNF signaling, suggesting a module where ubiquitin-mediated regulation modulates innate immunity and inflammatory signaling. Some terms like response to vitamin D and skeletal muscle differentiation are present but do not define the core theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0033209","count":5},{"id":"GO:0051607","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0016567","count":4}]},{"hash":"1488293989960074419","title":"Viral integration and host-cell manipulation","description":"The top terms cluster around DNA integration, proviral latency establishment, and viral/symbiont entry into host cells, with related apoptotic signaling and DNA transposition. This pattern points to processes involving viral genome integration and subsequent manipulation of host cell fate, including apoptosis, consistent with proviral latency and host interaction themes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":8},{"id":"GO:0075713","count":4},{"id":"GO:0046718","count":3},{"id":"GO:0075732","count":2},{"id":"GO:0039651","count":2}]},{"hash":"1404570378664815705","title":"DNA replication and chromatin maintenance","description":"The top GO terms are dominated by nuclear processes, especially DNA replication and chromatin-related functions (nucleosome positioning, heterochromatin maintenance, histone exchange). Additional terms point to RNA processing and ribosome biogenesis (mitochondrial ribosomal subunit assembly, rRNA maturation) and general protein import, suggesting a cluster centered on core genome maintenance and gene expression machinery, with some mitochondrial-related activity. Overall, the strongest signal is DNA replication and chromatin regulation.","confidence":"Medium","size":21,"edges":6,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0048701","count":6},{"id":"GO:1902775","count":5},{"id":"GO:0071038","count":5},{"id":"GO:0016584","count":5}]},{"hash":"1953385623957230540","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0002192","count":2},{"id":"GO:0000463","count":2},{"id":"GO:1902626","count":2},{"id":"GO:0001731","count":2}]},{"hash":"1654424993816389937","title":"Proviral DNA Integration and Transposition","description":"Top GO terms point to DNA integration, DNA transposition, and proviral latency, with supporting signals for transcription regulation and cell cycle. This pattern indicates a set of proteins involved in integrating genetic material into host genomes (retroviral or transposon-like) and coordinating transcription, aligning well with a \u201cproviral DNA integration and transposition\u201d function. The presence of symbiont entry into host cells adds context but does not outweigh the core integration/transposition theme.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0075713","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0006355","count":2},{"id":"GO:0007059","count":2}]},{"hash":"634805712941889057","title":"Ribosome biogenesis and translation","description":"The top terms are dominated by translation- and ribosome-related processes (translation, cytoplasmic translation, ribosome biogenesis, maturation of SSU-rRNA, ribosomal subunit assembly, translational termination), indicating this cluster represents components of the protein synthesis machinery. A few ancillary terms (interleukin-4 response, antibiotic response, oskar mRNA localization, spliceosome regulation) are present but far less prominent, suggesting they are peripheral to the main theme.","confidence":"High","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":16},{"id":"GO:0000027","count":4},{"id":"GO:0071353","count":3},{"id":"GO:0002181","count":2},{"id":"GO:0042254","count":2}]},{"hash":"524791977944512607","title":"Developmental signaling and morphogenesis","description":"These proteins appear linked to developmental signaling and tissue morphogenesis. The top GO terms include skeletal system development, lung branching morphogenesis, and brown adipose differentiation, suggesting roles in tissue differentiation. Additional terms on GPCR acetylcholine signaling, receptor clustering, PI3K/AKT pathway regulation, and heterophilic cell-cell adhesion point to signaling and adhesion mechanisms that drive morphogenesis and organ formation. Oxidation-reduction and detox terms may reflect redox regulation in development but are less central. Overall, the cluster seems to represent developmental signaling and morphogenesis.","confidence":"Medium","size":21,"edges":63,"triangles":65,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":12},{"id":"GO:0001501","count":9},{"id":"GO:0098869","count":9},{"id":"GO:0007213","count":9},{"id":"GO:0051897","count":9}]},{"hash":"2249982992017617922","title":"Unknown","description":"The GO terms span several unrelated processes (bradykinin and collagen catabolic processes, chromatin organization, transcription, ribosome biogenesis, and myelin assembly), with no single shared function linking all proteins. The absence of edges and use of obsolete terms further indicate a heterogeneous cluster that cannot be summarized by a cohesive label.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010815","count":2},{"id":"GO:0035551","count":2},{"id":"GO:0034396","count":2},{"id":"GO:0034724","count":2},{"id":"GO:0030574","count":2}]},{"hash":"405398366311128148","title":"Proviral latency and viral integration","description":"The top GO terms cluster around retroviral processes: establishment of integrated proviral latency, DNA integration, viral penetration into the host nucleus, reverse transcription-related RNA-templated DNA biosynthesis, and DNA replication/recombination. This pattern points to steps in the retroviral life cycle (entry, reverse transcription, integration, latency) and host-pathogen interaction, justifying the label as a Proviral latency and integration cluster.","confidence":"High","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0075713","count":10},{"id":"GO:0015074","count":10},{"id":"GO:0075732","count":10},{"id":"GO:0006260","count":10},{"id":"GO:0039651","count":10}]},{"hash":"434693774139951821","title":"Actin cytoskeleton organization and cell junctions","description":"This cluster is dominated by GO terms related to actin dynamics and cell\u2013cell junctions, including actomyosin structure organization and actin filament bundle assembly, as well as cell-cell junction organization, pointing to a cohesive theme of cytoskeletal remodeling and adhesion. Some terms are more divergent (developmental or signaling), but the core signals consistently emphasize actin-based organization and junctional integrity. ","confidence":"High","size":21,"edges":133,"triangles":431,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0070527","count":7},{"id":"GO:0010088","count":6},{"id":"GO:0090334","count":6},{"id":"GO:0045216","count":6}]},{"hash":"262417923948121101","title":"Apoptosis and oxidative stress regulation","description":"Top GO terms indicate a core theme of apoptosis regulation, including extrinsic and mitochondrial pathways, and regulation of hydrogen peroxide metabolism, pointing to cell death decisions under stress. Some annotations (developmental segmentation, immune-related biosynthesis) appear peripheral, suggesting noise outside the main apoptotic/stress-response signal. Medium","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902042","count":2},{"id":"GO:0009697","count":1},{"id":"GO:0045347","count":1},{"id":"GO:0010310","count":1},{"id":"GO:0010188","count":1}]},{"hash":"1543716541776168298","title":"Epithelial Polarity and Junction Assembly","description":"The cluster shows strong enrichment for processes related to epithelial cell apical/basal polarity, tight junction assembly, and microvillus formation, as well as focal adhesion and cytoskeletal organization (Rho signaling, centrosome localization, endosome targeting). These themes point to coordinated control of cell polarity, adhesion, and membrane\u2013domain organization in epithelial cells, with additional signaling ties seen in nitric-oxide synthase regulation and synapse plasticity that may reflect broader signaling roles. Overall, the dominant pattern is epithelial polarity and junction assembly.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0051835","count":4},{"id":"GO:0051000","count":4},{"id":"GO:0008285","count":4},{"id":"GO:1902966","count":4},{"id":"GO:0051660","count":4}]},{"hash":"1215422795703836402","title":"Carbohydrate and thiol biosynthesis in bacteria","description":"Most top terms point to biosynthetic pathways for carbohydrates and low-molecular-weight thiols (mycothiol, bacillithiol), as well as glycosylation and glycoconjugate formation, which are characteristic of bacterial envelope metabolism and redox balance. Some terms (DNA recombination; responses to water deprivation and sorbitol) are stress- or DNA-related and less central to the core theme. The shared thread is the synthesis of carbohydrate-containing structures and thiol-dependent metabolites in bacteria.","confidence":"Medium","size":21,"edges":17,"triangles":0,"max_degree":6,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":9},{"id":"GO:0019252","count":7},{"id":"GO:0097502","count":7},{"id":"GO:0009414","count":7},{"id":"GO:0010125","count":7}]},{"hash":"2175931727442792146","title":"Neuropeptide signaling and cardiovascular/immune regulation","description":"This cluster centers on neuropeptide signaling and neuroendocrine control of cardiovascular and immune processes, as indicated by terms like neuropeptide signaling pathway, regulation of vasopressin-mediated blood pressure, renin secretion, and dopamine uptake regulation, together with chemokine and IL-1 beta production regulation. The combination suggests a cohesive neuroendocrine-vascular-immune module rather than disparate functions.","confidence":"High","size":21,"edges":4,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":21},{"id":"GO:0032651","count":21},{"id":"GO:0007218","count":21},{"id":"GO:2000724","count":21},{"id":"GO:0090075","count":21}]},{"hash":"1937671867742482457","title":"Neuroendocrine signaling and thermoregulation","description":"The terms point to neural and neuropeptide control of temperature response, thermogenesis, pain signaling, and vascular regulation (vasopressin, dopamine uptake), indicating a cohesive neuroendocrine signaling theme governing metabolic and cardiovascular responses to stimuli.","confidence":"High","size":21,"edges":133,"triangles":385,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":17},{"id":"GO:0002024","count":17},{"id":"GO:0019233","count":17},{"id":"GO:0043950","count":16},{"id":"GO:0032651","count":16}]},{"hash":"1681960343256227218","title":"Cytoskeleton Remodeling and Membrane Trafficking","description":"The proteins in this cluster center on cytoskeletal organization (actin filament bundle assembly, spindle assembly) and membrane trafficking (pinocytosis regulation, SNARE complex assembly regulation), with related themes in epithelial polarity and mechanotransduction. These recurring themes point to structural dynamics of the cell cortex, division, and vesicle trafficking rather than a single isolated pathway, justifying a cytoskeleton and trafficking-focused label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":8},{"id":"GO:0048549","count":8},{"id":"GO:0051225","count":7},{"id":"GO:0035994","count":7},{"id":"GO:0035544","count":7}]},{"hash":"161455753263788486","title":"Cardiac development and conduction signaling","description":"The cluster centers on cardiac formation and electrical conduction, highlighted by outflow tract morphogenesis, Purkinje-to-ventricular signaling, and SA node action potential regulation; these dominate the GO terms, with supporting references to multicellular development and hypoxia response. Some bone ossification and cell-cycle terms may reflect broader developmental programs, but the cardiac theme remains the most coherent.","confidence":"Medium","size":21,"edges":4,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0043931","count":5},{"id":"GO:0086029","count":4},{"id":"GO:0003151","count":4},{"id":"GO:0098907","count":4}]},{"hash":"1325503222030351399","title":"Cytoskeleton Dynamics and Cell Polarity","description":"The top GO terms cluster around actin filament bundle assembly, spindle assembly, and establishment of epithelial cell polarity, pointing to proteins involved in cytoskeletal remodeling and cell architecture. Other terms touch on mechanical response and regulation of vesicle trafficking, suggesting a broader theme of cellular organization; the presence of obsolete terms and lack of interactions means the connection isn't perfect, but the dominant signal is cytoskeletal dynamics and cell polarity.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0032088","count":4},{"id":"GO:0051225","count":3},{"id":"GO:0035994","count":3},{"id":"GO:0035544","count":3},{"id":"GO:0051017","count":3}]},{"hash":"994170529522747465","title":"Heart development and endothelial differentiation","description":"The top GO terms cluster around heart formation (cardiac right atrium morphogenesis; Notch signaling in regulation of secondary heart field cardioblast proliferation), along with venous endothelial differentiation and mechanotransduction, indicating a cohesive theme of cardiac development and vascular differentiation. Some terms (cytokinin-activated signaling, vitamin D response) appear peripheral and may reflect broader or cross-species annotations, but the core signal supports heart/endothelial biology.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009736","count":3},{"id":"GO:0046661","count":3},{"id":"GO:0032088","count":2},{"id":"GO:0060843","count":2},{"id":"GO:0071260","count":2}]},{"hash":"286690463172872910","title":"Neuroendocrine signaling and blood pressure regulation","description":"The proteins show enrichment for neuropeptide signaling, vasopressin-mediated regulation of systemic arterial blood pressure, renin secretion, and modulation of dopamine uptake and muscle relaxation, pointing to a coherent theme of neuroendocrine control of cardiovascular function and related inflammatory processes.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":21},{"id":"GO:0032651","count":21},{"id":"GO:0007218","count":21},{"id":"GO:2000724","count":21},{"id":"GO:0090075","count":21}]},{"hash":"519156274346035946","title":"Retroviral DNA integration and latency","description":"This cluster centers on DNA integration, recombination, RNA-templated DNA synthesis (reverse transcription), DNA replication, and establishment of integrated proviral latency, all indicative of retroviral life cycle steps and provirus maintenance; the viral/host interaction terms further support a retroviral processing theme.","confidence":"High","size":21,"edges":11,"triangles":0,"max_degree":5,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0006278","count":3},{"id":"GO:1903704","count":3},{"id":"GO:0075713","count":3}]},{"hash":"451119346224365262","title":"Lipid Metabolism and Lipoprotein Remodeling","description":"Based on the top GO terms, the proteins are enriched for triglyceride catabolic process, triglyceride homeostasis, lipid digestion, and remodeling of HDL/LDL/VLDL particles, as well as intestinal cholesterol absorption and reverse cholesterol transport. This pattern points to a cohesive lipid metabolism and lipoprotein transport function, indicating a shared role in lipid processing and lipoprotein remodeling rather than a single enzymatic pathway.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":6},{"id":"GO:0034375","count":4},{"id":"GO:0070328","count":4},{"id":"GO:0009395","count":4},{"id":"GO:0034374","count":4}]},{"hash":"28226397474566197","title":"Innate Immune Activation and Phagocytosis","description":"The top GO terms cluster around complement activation (lectin pathway), phagocytosis recognition, basophil activation, and responses to fungal origin, indicating innate immune recognition and inflammatory signaling as the core theme. Some developmental terms appear but are likely incidental and not defining the cluster, so the label emphasizes immune activation and clearance processes.","confidence":"High","size":21,"edges":15,"triangles":3,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001867","count":9},{"id":"GO:0006910","count":8},{"id":"GO:0072287","count":8},{"id":"GO:0010572","count":8},{"id":"GO:0090403","count":8}]},{"hash":"686084628806268342","title":"Immune Inflammatory Signaling","description":"The proteins show strong enrichment for inflammatory and immune-activation terms (inflammatory response, chemokine production, immunoglobulin-mediated immunity, and complement activation) with NF-kB signaling (I-kappaB phosphorylation). Some developmental terms appear (gonad, skeletal) but the core signal points to immune/inflammatory function.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":6},{"id":"GO:0008584","count":6},{"id":"GO:0090197","count":6},{"id":"GO:0016064","count":6},{"id":"GO:0001501","count":5}]},{"hash":"621407180647251545","title":"Immune signaling and vesicle trafficking","description":"The top GO terms converge on immune signaling (T cell receptor signaling, interferon production, MAP kinase regulation) and intracellular trafficking (endosomal vesicle fusion, Golgi-to-ER retrograde transport), with additional cues for cytoskeletal remodeling (filopodium assembly) and mechanical response. This suggests a cohesive role for the cluster in transducing immune signals while coordinating vesicle trafficking and cytoskeletal dynamics.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":3},{"id":"GO:0034058","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0032729","count":3},{"id":"GO:0071260","count":3}]},{"hash":"1511120192861566887","title":"Innate immune signaling and endosomal trafficking","description":"The top terms cluster around innate immunity, endosomal transport, and NF-kappaB signaling (defense against Gram-positive bacteria, innate immune response, and NF-kB regulation), suggesting a functional group focused on immune signaling with endosomal/trafficking roles. Some terms appear ancillary (neural tube closure, food response), but the core theme fits innate immune pathways and endosomal processes.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016197","count":2},{"id":"GO:0010745","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0051092","count":2}]},{"hash":"117581194883769341","title":"Developmental Signaling and Neural Patterning","description":"The cluster shows strong enrichment for signaling pathways tied to development and neural patterning (Roundabout, ERK cascade, Hedgehog/smoothened), along with broader organ development terms (heart and kidney). There are also related terms like T cell signaling and ion-channel clustering that may reflect neuronal excitability and broader signaling cross-talk, but the dominant theme is developmental signaling across multiple tissues.","confidence":"Medium","size":21,"edges":81,"triangles":62,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035385","count":8},{"id":"GO:0070374","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0045163","count":7},{"id":"GO:0007507","count":7}]},{"hash":"1844729849684328256","title":"Immune Response Regulators","description":"These proteins are enriched for immune-related GO terms, including adaptive and innate immune responses and IL-2 production, suggesting roles in immune signaling. The presence of terms regulating Rho signaling and dendritic spine development hints at additional signaling/regulatory functions, but overall the dominant theme appears to be immune response regulation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0061000","count":4},{"id":"GO:0010863","count":4},{"id":"GO:0043552","count":4}]},{"hash":"1648722956961976068","title":"Unknown","description":"The terms are heterogeneous, with no single dominant function. Top GO terms span cytolysis, ubiquitin-dependent endocytosis, desumoylation regulation, transcription by RNA polymerase II, phototransduction, protein binding regulation, hormone signaling, androgen receptor pathway regulation, and defense response. Because there isn't a cohesive biological process linking these proteins, this cluster cannot be confidently assigned to a specific function and is labeled Unknown.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019835","count":1},{"id":"GO:0070086","count":1},{"id":"GO:0060189","count":1},{"id":"GO:0045944","count":1},{"id":"GO:0007602","count":1}]},{"hash":"1071944486488309898","title":"Unknown","description":"The listed GO terms are diverse, including signaling pathways (Smoothened, Roundabout, Fc-epsilon receptor), developmental processes (kidney development), cell cycle/division, ribosome biogenesis, and ion channel regulation. There is no single dominant function tying these proteins together, and there are no observed edges among them, suggesting a heterogeneous set rather than a coherent, shared biological role. ","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007224","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0038095","count":2},{"id":"GO:0035385","count":2}]},{"hash":"941058640072853941","title":"Neuropeptide signaling and blood pressure regulation","description":"The top GO terms cluster around neuropeptide signaling, dopamine signaling, vasopressin- and renin-regulated cardiovascular processes, and smooth muscle relaxation/differentiation, suggesting a theme of neuroendocrine signaling coordinating neural and cardiovascular functions. Some inflammatory terms appear but do not dominate the overall theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":20},{"id":"GO:0043950","count":19},{"id":"GO:0032651","count":19},{"id":"GO:0007218","count":19},{"id":"GO:2000724","count":19}]},{"hash":"1447270775027107786","title":"Thermogenesis and metabolic signaling cluster","description":"This cluster is dominated by GO terms related to temperature response and diet-induced thermogenesis, with supporting signals from GPCR- and Rho-mediated pathways, energy metabolism (electron transport chain), and linked physiological outputs (blood pressure, locomotion) as well as inflammatory signaling (IL-1\u03b2). The common thread appears to be thermogenesis and integrated metabolic signaling in response to thermal stress, rather than a single narrowly defined function, making \"Thermogenesis and metabolic signaling cluster\" a concise, representative label.","confidence":"Medium","size":21,"edges":2,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":15},{"id":"GO:0002024","count":15},{"id":"GO:0019233","count":15},{"id":"GO:0010579","count":13},{"id":"GO:0035025","count":13}]},{"hash":"101323909940186909","title":"Neuropeptide signaling and blood pressure regulation","description":"These 21 proteins cluster around neuropeptide signaling and hormonal control of cardiovascular function. The top GO terms include neuropeptide signaling, regulation of systemic arterial blood pressure by vasopressin, positive regulation of renin secretion, and regulation of dopamine uptake, all pointing to neuroendocrine control of vascular tone and blood pressure. While there are also immune-related terms (cytokine/chemokine regulation), the dominant pattern is neuropeptide-driven signaling impacting cardiovascular regulation, supporting this label.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":21},{"id":"GO:0032651","count":21},{"id":"GO:0007218","count":21},{"id":"GO:2000724","count":21},{"id":"GO:0090075","count":21}]},{"hash":"385981570676542008","title":"Cardiovascular development and signaling","description":"This cluster\u2019s top GO terms center on heart development, vascular smooth muscle differentiation, and blood pressure regulation (including vasopressin), plus neuropeptide signaling and ERK pathway modulation, indicating proteins involved in cardiovascular development and its signaling networks. A minority of terms relate to immune defense, but they do not dominate. Overall, the cluster appears tied to cardiovascular development and signaling rather than a single other function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":19},{"id":"GO:0042742","count":19},{"id":"GO:0070374","count":19},{"id":"GO:0043950","count":18},{"id":"GO:0032651","count":18}]},{"hash":"1816322688484526881","title":"Neuropeptide signaling and vascular regulation","description":"The cluster is dominated by neuropeptide signaling and cardiovascular-related GO terms, including neuropeptide signaling pathways, vasopressin-regulated blood pressure, renin secretion, and dopamine uptake modulation. Additional terms touch on inflammatory signaling and muscle relaxation, suggesting a cohesive theme around neuroendocrine control of vascular function and related physiological regulation.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":21},{"id":"GO:0032651","count":21},{"id":"GO:0007218","count":21},{"id":"GO:2000724","count":21},{"id":"GO:0090075","count":21}]},{"hash":"1493217716655823106","title":"Unknown","description":"The top terms spread across neural signaling, immune activation, and muscle differentiation with no clear unifying function or pathway. Without a cohesive theme among the terms, a specific label isn\u2019t justifiable.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0042102","count":4},{"id":"GO:0050910","count":4},{"id":"GO:0031295","count":4}]},{"hash":"1316420437446989170","title":"Broad Substrate Membrane Transporters","description":"The GO terms show transmembrane transport for a variety of substrates (nitrate, nitrite, sugars like galactose/arabinose/fucose, sodium ions, xenobiotics) and even a vesicular neurotransmitter transporter, indicating these proteins are broadly involved in solute transport across membranes.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042128","count":8},{"id":"GO:0098700","count":6},{"id":"GO:0015707","count":6},{"id":"GO:0015706","count":6},{"id":"GO:0035725","count":6}]},{"hash":"2233039922680501044","title":"Exocytic and endosomal trafficking in immune cells","description":"Top terms indicate a core of vesicle docking/tethering in exocytosis, exosomal secretion, and endosome localization/transport, with additional immune signaling terms (germinal center formation, B cell receptor signaling, Toll pathway). This suggests a cluster of proteins that link vesicle trafficking to immune signaling processes in B cells and related immune responses. Confidence: Medium","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006904","count":2},{"id":"GO:0090522","count":2},{"id":"GO:0002467","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0036010","count":1}]},{"hash":"1328883147613628535","title":"Cardiac GPCR Signaling and Contraction Regulation","description":"This cluster centers on GPCR signaling and its regulation in cardiac tissue, including GPCR desensitization/internalization, acetylcholine receptor signaling, and cardiac muscle contraction/heart development terms, suggesting a cohesive theme of GPCR-mediated control of cardiac function.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030512","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0003108","count":2},{"id":"GO:0002029","count":2},{"id":"GO:0060048","count":2}]},{"hash":"2083895487319612200","title":"RNA processing and gene expression regulators","description":"The strongest signals are RNA processing functions (mRNA splicing via spliceosome and miRNA catabolic process), complemented by roles in protein interaction regulation, cell proliferation, and development. A subset of terms also hints at host\u2013pathogen interactions (symbiont entry, viral release), suggesting multifunctionality. Overall, the cluster appears centered on RNA processing and gene-expression regulation with related developmental and interaction roles.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0035871","count":2},{"id":"GO:1902042","count":2}]},{"hash":"799857774255745370","title":"Paranode localization and axon guidance","description":"These proteins are strongly linked to localization at paranode/juxtaparanode regions of axons, paranodal junction assembly, and multiple neuron projection guidance processes (sympathetic, branchiomotor, trigeminal). The presence of semaphorin-plexin signaling in axon guidance further supports a role in axon pathfinding and peripheral nervous system organization, making this a concise, representative label.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002175","count":7},{"id":"GO:0030913","count":7},{"id":"GO:0071205","count":7},{"id":"GO:0014068","count":6},{"id":"GO:0097491","count":6}]},{"hash":"1117968340964665280","title":"Unknown","description":"The terms are scattered across proteolysis, glycosylation, autophosphorylation signaling, and various stress or signaling responses (prolactin, BDNF, anoxia), with no clear, shared functional theme tying the majority of proteins together. Confidence is None.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:0006487","count":1},{"id":"GO:1990637","count":1},{"id":"GO:0016340","count":1},{"id":"GO:0070266","count":1}]},{"hash":"1685803379260790197","title":"Coagulation, fibrinolysis, and vascular development","description":"The top terms center on blood coagulation, plasminogen activation, and positive regulation of fibrinolysis, with supportive terms for vascular function (vasoconstriction, lymph circulation) and heart development (endocardial cushion formation). Mechanical stimulus response and bone trabecula formation suggest remodeling in a mechanically active tissue context, but the dominant signal ties coagulation and vascular development together, justifying a label focused on coagulation and vascular remodeling.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0031639","count":6},{"id":"GO:0045907","count":5},{"id":"GO:0060346","count":5},{"id":"GO:0071260","count":5}]},{"hash":"1336104000858452671","title":"ER stress response and signaling","description":"Most terms point to cellular stress responses and signaling pathways, especially the endoplasmic reticulum unfolded protein response, ER-to-Golgi transport, and several signaling cascades (growth hormone, insulin receptor, calcineurin\u2013NFAT, osteoclast differentiation). An outlier term (DNA integration) exists, but the dominant theme is ER stress\u2013related regulation of intracellular signaling, supporting this label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0033160","count":3},{"id":"GO:0008625","count":2},{"id":"GO:1900103","count":2},{"id":"GO:0035621","count":2}]},{"hash":"1602892254013753954","title":"Neural membrane trafficking and barrier formation","description":"The terms cluster around membrane organization and transport in neural contexts\u2014transcytosis, tight junction/bicellular junction assembly, and membrane raft polarization\u2014together with endothelial barrier establishment and myelination. Neural development terms (substantia nigra development, regulation of synaptic plasticity) further support a brain-focused membrane-dynamics theme. Overall, this cluster seems to describe proteins coordinating membrane trafficking and barrier properties in the nervous system.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045056","count":3},{"id":"GO:0042552","count":3},{"id":"GO:0061028","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0048169","count":3}]},{"hash":"1265379872828886217","title":"Nuclear gene expression and ribosome biogenesis","description":"This cluster centers on nucleosome assembly, transcription regulation by RNA polymerase II, and ribosome biogenesis, pointing to nuclear processes that govern gene expression and protein synthesis. Some terms such as sporulation and cytokine response appear as outliers or broader annotations, but the dominant signal suggests coordination of chromatin organization and ribosome production. ","confidence":"Medium","size":20,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032120","count":2},{"id":"GO:0006334","count":2},{"id":"GO:0007586","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0042254","count":1}]},{"hash":"1406215323091479740","title":"Unknown","description":"The top GO terms cover sporulation, innate immunity, brain and lung development, antibiotic response, metabolism, T cell differentiation, metal ion response, proteasomal regulation, and protein heterooligomerization. This broad, disjoint set shows no single coherent function or pathway tying the proteins together, so a meaningful specific label cannot be assigned.","confidence":"","size":20,"edges":19,"triangles":4,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0030435","count":4},{"id":"GO:0045087","count":3},{"id":"GO:0030324","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0045150","count":3}]},{"hash":"1905127768544732237","title":"Proviral Integration and Latency","description":"This cluster centers on GO terms for proviral latency establishment and DNA integration, including viral genome entry into the host nucleus, suggesting integration-based viral or retroelement activity. Additional terms like retrotransposition and DNA replication reflect host\u2013virus interactions and genome maintenance during infection.","confidence":"High","size":20,"edges":6,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0075713","count":5},{"id":"GO:0015074","count":5},{"id":"GO:0075732","count":5},{"id":"GO:0039651","count":5},{"id":"GO:0046718","count":5}]},{"hash":"671343123037157223","title":"Mitochondrial energy metabolism and transcription","description":"The top GO terms cluster around energy production and metabolic flux (mitochondrial electron transport, ketone body biosynthesis, response to starvation, transport), with additional signals of gene expression control (translation, DNA-templated transcription). The occasional plant-specific term (photosynthesis) may reflect annotation cross-talk or broader energy-related processes rather than a true functional trend; overall, the proteins appear linked to energy generation and regulation of transcription/translation.","confidence":"Medium","size":20,"edges":142,"triangles":684,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006123","count":3},{"id":"GO:0042594","count":3},{"id":"GO:0046951","count":3},{"id":"GO:0001889","count":3},{"id":"GO:0006412","count":2}]},{"hash":"1033294431009237856","title":"Neurovascular development and Notch signaling","description":"This cluster centers on neural development (axon extension, paranodal/juxtaparanodal localization) and Notch pathway regulation, with adjacent vascular remodeling signals (blood coagulation, plasminogen activation/fibrinolysis, coronary artery morphogenesis). The combination suggests proteins coordinating neurodevelopment with vascular remodeling, possibly via Notch signaling and extracellular proteolysis at neurovascular interfaces.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045746","count":9},{"id":"GO:0048846","count":8},{"id":"GO:0055114","count":8},{"id":"GO:0031639","count":8},{"id":"GO:0030913","count":8}]},{"hash":"2282305972049686285","title":"Translation and Protein Quality Control","description":"This cluster centers on translation (GO:0006412), SRP-dependent cotranslational targeting to membrane, chaperone-assisted folding, proteasome regulatory particle assembly, and protein oligomerization, indicating a cohesive theme of protein synthesis and downstream folding/quality control. Some xenobiotic/antibiotic response terms appear as ancillary stress-related signals but do not disrupt the core theme.","confidence":"Medium","size":20,"edges":35,"triangles":17,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0046677","count":2},{"id":"GO:0070389","count":2},{"id":"GO:0006260","count":2}]},{"hash":"555702052899574445","title":"Unknown","description":"The top terms are diverse and include methylation and one-carbon/folate metabolism, DNA transposition, metal ion response, endothelial proliferation, and other disparate processes, with no edges linking the proteins. This lack of a single cohesive theme makes it inappropriate to assign a specific functional label.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032259","count":2},{"id":"GO:0010038","count":2},{"id":"GO:0090305","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0001935","count":1}]},{"hash":"98536859428056531","title":"Plant stress responses and mitochondrial organization","description":"The top GO terms point to intracellular distribution of mitochondria, photosynthesis, and cellular responses to environmental stress signals (cadmium, dsRNA). Although there is an outlier about maintenance of animal organ identity, the dominant theme is mitochondrial organization coupled with stress-response and energy-related processes typical of plants, justifying the label.","confidence":"Medium","size":20,"edges":10,"triangles":1,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048496","count":11},{"id":"GO:0048312","count":10},{"id":"GO:0071360","count":10},{"id":"GO:1903646","count":10},{"id":"GO:0051348","count":10}]},{"hash":"207273903078367677","title":"Auditory and vestibular synaptic signaling","description":"Top GO terms center on neural signaling and sensory processing, including glutamatergic synaptic transmission, synapse plasticity, ERK signaling, and perception of sound and equilibrioception. While a few terms (DNA replication, immune regulation) are less coherent with this theme, the dominant signal supports labeling this cluster as neural sensory processing related to hearing and balance.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0043029","count":4},{"id":"GO:0051968","count":4},{"id":"GO:0045577","count":3},{"id":"GO:0007605","count":3}]},{"hash":"1285491025195953546","title":"Inflammatory and stress signaling","description":"The top GO terms center on inflammatory signaling (interleukin-1 signaling, LPS signaling) and stress-responsive pathways (JNK cascade, NF-kappaB related activity, PI3K signaling) with links to apoptosis (death-inducing signaling complex) and DNA damage responses. This pattern points to a cluster of proteins involved in inflammatory and cellular stress signaling that can lead to cell fate decisions like apoptosis, with some neuronal signaling context noted by a behavioral response term.  ","confidence":"High","size":20,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0070498","count":15},{"id":"GO:0046330","count":15},{"id":"GO:0035994","count":15},{"id":"GO:0071550","count":15},{"id":"GO:0031663","count":15}]},{"hash":"1374336801190877052","title":"DNA transposition and proviral integration","description":"Based on the top GO terms, the cluster is centered on DNA transposition, DNA integration, and proviral latency establishment, indicating mobile genetic elements and viral genome integration activity. A few cell cycle terms appear as background associations, but the dominant signal is transposition/proviral integration.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":5},{"id":"GO:0015074","count":3},{"id":"GO:0075713","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0007049","count":2}]},{"hash":"254476912133954430","title":"Innate Immune Signaling and Pyroptotic Death","description":"The top GO terms cluster around antiviral innate immunity (innate immune response, defense against virus, TLR4 signaling, NOD2 pathway), inflammatory cell death (pyroptotic inflammatory response, apoptotic process), and regulatory ubiquitination, suggesting a cohesive group of proteins involved in innate immune signaling and pyroptosis. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016567","count":17},{"id":"GO:0070269","count":16},{"id":"GO:1990001","count":16},{"id":"GO:0090307","count":16},{"id":"GO:0045087","count":16}]},{"hash":"1749563930031194387","title":"Cardiac development and mechanical signaling","description":"The top GO terms strongly point to heart formation, including cardiac right atrium morphogenesis and Notch-regulated heart field cardioblast proliferation, indicating a cardiac-development theme. Additional terms related to mechanotransduction\u2014cellular response to mechanical stimulus and response to muscle stretch\u2014and cytoskeletal processes like actin filament bundle assembly support a mechanosensitive, morphogenesis-focused cluster. Peripheral terms about adipocyte differentiation and macrophage foam cell differentiation are present but secondary to the main cardiac signal. Overall, the cluster appears best described by heart development with mechanical signaling.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0010745","count":6},{"id":"GO:0060843","count":6},{"id":"GO:0045444","count":6},{"id":"GO:0071260","count":6},{"id":"GO:0003213","count":6}]},{"hash":"774540657988221705","title":"Innate Immune Signaling and Kidney Morphogenesis","description":"The top GO terms show strong enrichment for innate immune processes (complement activation via lectin pathway, phagocytosis recognition, basophil activation, response to fungal origin, arachidonate signaling, platelet activation) alongside several kidney development/morphogenesis terms (mesonephric duct development, metanephric proximal/distal tubule morphogenesis). This suggests a function tied to inflammatory signaling with roles in renal tissue development, hence the combined label.","confidence":"Medium","size":20,"edges":12,"triangles":3,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":18},{"id":"GO:0010572","count":15},{"id":"GO:0001502","count":15},{"id":"GO:0001867","count":15},{"id":"GO:0090238","count":14}]},{"hash":"1675761746033482331","title":"Autophagy and lysosome targeting","description":"The top GO terms cluster around degradation and lysosomal trafficking: phagophore assembly site localization, pexophagy, CVT pathway delivery to the vacuole, and protein targeting to lysosome, plus secretion of lysosomal enzymes and general protein localization to lysosome. Lipid metabolism terms may reflect membrane dynamics and energy needs during autophagy. This suggests a cohesive function in autophagy-lysosome pathways with related trafficking roles.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034497","count":1},{"id":"GO:0030242","count":1},{"id":"GO:0033299","count":1},{"id":"GO:0032258","count":1},{"id":"GO:0006622","count":1}]},{"hash":"1781663856311237952","title":"Viral DNA replication and proviral integration","description":"This cluster is dominated by GO terms tied to DNA replication, RNA-templated DNA synthesis (reverse transcription), DNA integration and recombination, and proviral latency establishment, all pointing to viral genome processing and integration into host DNA, with related host interaction signals (virus entry into nucleus and symbiont-induced host responses). Confidence: High","confidence":"","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0006278","count":4},{"id":"GO:1903704","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4}]},{"hash":"1236867691146818583","title":"Inflammation-driven vascular and smooth muscle signaling","description":"This cluster is enriched for inflammatory terms (inflammatory response, response to lipopolysaccharide), vascular and smooth muscle regulation (positive regulation of vasoconstriction, negative regulation of smooth muscle contraction, blood coagulation), calcium signaling (release of sequestered calcium into cytosol), and signaling pathways that control muscle contraction and cytoskeletal dynamics (Rho signaling). The presence of sensory pain and temperature-related terms fits with an inflammatory context that influences nociception and vascular tone. Together they suggest a coherent theme of inflammatory vascular and smooth muscle response.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":16},{"id":"GO:0045907","count":15},{"id":"GO:0071502","count":14},{"id":"GO:0006954","count":14},{"id":"GO:0032496","count":14}]},{"hash":"1837088454503713519","title":"Mitochondrial Transport and Fission","description":"The top GO terms cluster around mitochondrial metabolism and transport, including malate-aspartate shuttle, alpha-ketoglutarate and ornithine transport, and metal ion transport (Mg/Mn), plus mitochondrial membrane fission/dynamics. A regulatory angle (insulin, fatty acid, amino acid starvation responses) suggests these proteins participate in mitochondrial metabolism and membrane remodeling rather than a single enzyme complex. ","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043490","count":10},{"id":"GO:0070542","count":10},{"id":"GO:0034198","count":10},{"id":"GO:0000066","count":10},{"id":"GO:0015742","count":10}]},{"hash":"1699850454563139881","title":"Neuroendocrine signaling and vascular regulation","description":"The proteins cluster around neuropeptide signaling, dopamine uptake in synaptic transmission, vasopressin-regulated blood pressure, and renin secretion, with muscle relaxation processes\u2014together pointing to neuroendocrine control of cardiovascular function. Immune-related terms (interleukin-1 beta production and chemokine regulation) may reflect signaling cross-talk but do not override the neuroendocrine-vascular theme.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":20},{"id":"GO:0032651","count":20},{"id":"GO:0007218","count":20},{"id":"GO:2000724","count":20},{"id":"GO:0090075","count":20}]},{"hash":"1492960195520042148","title":"Neuropeptide signaling and vascular-immune regulation","description":"The top GO terms cluster around neuropeptide signaling (GO:0007218) and vascular regulation via vasopressin and renin (GO:0001992, GO:1900135), with additional terms touching dopamine uptake and smooth muscle relaxation/differentiation, suggesting neuroendocrine control of vascular tone. Immune signaling terms (IL-1\u03b2 production, chemokine production) indicate concurrent inflammatory modulation. Together, these terms point to a cluster of proteins involved in neuropeptide- and endocrine-driven regulation of vascular function with immune signaling interactions.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":16},{"id":"GO:0032651","count":16},{"id":"GO:0007218","count":16},{"id":"GO:2000724","count":16},{"id":"GO:0090075","count":16}]},{"hash":"1747823983876871880","title":"Neuropeptide signaling and blood pressure regulation","description":"Top GO terms cluster around neuropeptide signaling, vasopressin/renin-mediated blood pressure regulation, and dopaminergic signaling, with accompanying regulation of IL-1\u03b2 and chemokine production, suggesting a neuroendocrine control of cardiovascular function and immune modulation. The label captures the core theme of neuropeptide/cardiovascular signaling represented by the cluster.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":20},{"id":"GO:0032651","count":20},{"id":"GO:0007218","count":20},{"id":"GO:2000724","count":20},{"id":"GO:0090075","count":20}]},{"hash":"1016606125770325674","title":"NF-kB\u2013driven inflammation and extrinsic apoptosis","description":"Proteins here are enriched for NF-kappaB signaling and extrinsic apoptotic pathway terms (including IL-1 signaling and canonical NF-kB signaling), suggesting a cohesive role in inflammatory regulation and apoptosis control. Despite zero edges, the GO pattern points to a functional cluster around NF-kB\u2013mediated inflammatory responses and modulation of extrinsic apoptosis.  ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902042","count":3},{"id":"GO:0006924","count":3},{"id":"GO:2001240","count":3},{"id":"GO:0070498","count":3},{"id":"GO:0032088","count":3}]},{"hash":"1734153809988337902","title":"Ubiquitin-Dependent Protein Turnover","description":"Most prominent GO terms center on ubiquitin pathways: ubiquitin-dependent protein catabolic process (7) and ubiquitination-related terms (K33-linked ubiquitination; negative regulation of protein ubiquitination). This points to a cluster of proteins involved in ubiquitin-mediated proteostasis and signaling. Other terms (B cell receptor signaling, germinal center formation, skeletal muscle and kidney development) are less frequent and may reflect multifunctional annotations or noise. Therefore, label as Ubiquitin-Dependent Protein Turnover.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0050853","count":5},{"id":"GO:0048741","count":5},{"id":"GO:0070294","count":5},{"id":"GO:0002467","count":5}]},{"hash":"1675403996222722047","title":"Neural signaling and sensory perception","description":"The top GO terms cluster around nervous system signaling and sensory processing: dopaminergic synaptic transmission, visual perception and learning, pain perception, and behavioral responses to psychoactive stimuli like cocaine, along with signaling pathway modulation (ERK cascade) and prostaglandin responses. While a couple of terms (heart development, macrophage chemotaxis) appear, they seem less central to the dominant theme, which points to neural communication and sensory processing.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":20},{"id":"GO:0010759","count":20},{"id":"GO:0001963","count":20},{"id":"GO:0007507","count":20},{"id":"GO:0008542","count":20}]},{"hash":"708599993469594043","title":"Neuronal adhesion and axon domain organization","description":"Based on the top GO terms, the cluster is dominated by cell\u2013cell adhesion activities (homophilic and heterophilic) and neural axon domain components (paranodal junctions and juxtaparanode localization). Additional terms indicate neuronal migration guidance and extracellular proteolysis, which together point to a cohesive function in neural adhesion and the organization of axon domains during development. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007156","count":11},{"id":"GO:0007157","count":11},{"id":"GO:0055114","count":11},{"id":"GO:0001501","count":11},{"id":"GO:0021836","count":11}]},{"hash":"2176685731506842613","title":"Embryonic neural development and neural crest migration","description":"This cluster\u2019s top GO terms are strongly tied to early neural development and neural crest\u2013derived lineages, including midbrain development, peripheral nervous system neuron development, retinal ganglion cell axon guidance, neural crest cell migration, and primitive streak formation. The presence of transcriptional regulation by RNA polymerase II suggests coordinated gene expression control during these developmental processes, with additional, more peripheral terms like lipopolysaccharide response and digestive tract morphogenesis likely reflecting broader embryonic roles or annotation overlap. Overall, the dominant theme is embryonic neural development and neural crest\u2013related differentiation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0032496","count":7},{"id":"GO:0030901","count":7},{"id":"GO:0021983","count":7},{"id":"GO:0090009","count":6}]},{"hash":"1404537976976905883","title":"Musculoskeletal and neural development","description":"The GO terms suggest involvement in muscle-related processes (positive regulation of smooth muscle contraction; cardiac muscle cell proliferation), bone formation (osteoblast differentiation), and spinal neural development (ventral spinal cord interneuron differentiation/fate commitment) as well as digit morphogenesis. Even though several terms are obsolete and there are no edges, the common theme appears to be developmental differentiation across muscle, bone, and spinal neural tissues, indicating a developmental program rather than a single specific function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0045987","count":4},{"id":"GO:0060038","count":3},{"id":"GO:0006147","count":3}]},{"hash":"774304250410798888","title":"Mitotic and meiotic cell cycle regulation","description":"Most top GO terms describe cell division processes, including mitotic sister chromatid separation, mitotic nuclear membrane reassembly, and female meiotic nuclear division, plus meiotic cell cycle regulation in oocyte maturation. Supporting terms involve nuclear transport (ribosomal protein import, mRNA transport) and regulatory layers (desumoylation, STAT signaling modulation). The shared theme is control of the cell cycle during mitosis/meiosis with related nuclear processes, justifying this label.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042518","count":6},{"id":"GO:0051306","count":6},{"id":"GO:0006610","count":6},{"id":"GO:0051028","count":6},{"id":"GO:0060561","count":6}]},{"hash":"1912246192766373176","title":"Unknown","description":"GO terms span DNA transposition, endothelial proliferation, smooth muscle development, extrinsic apoptotic signaling, endocytic recycling, Rac/Rho signaling regulation, pH response, and growth-rate regulation. The diverse and disparate functions provide no single cohesive theme for a meaningful label, so Unknown is appropriate.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":1},{"id":"GO:0001935","count":1},{"id":"GO:0008625","count":1},{"id":"GO:0048745","count":1},{"id":"GO:2001136","count":1}]},{"hash":"1152662386517490555","title":"Dendritic spine morphogenesis and synaptic vesicle regulation","description":"The GO terms cluster around neuronal synapse formation and plasticity: positive regulation of dendritic spine development/morphogenesis, regulation of lamellipodium assembly (growth/adaptation of cellular protrusions), regulation of synaptic vesicle endocytosis, and cellular responses related to dopamine and nerve branching. This points to a set of proteins coordinating dendritic spine maturation, vesicle cycling at synapses, and neuronal arborization.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010796","count":2},{"id":"GO:0061001","count":2},{"id":"GO:0010592","count":2},{"id":"GO:1900242","count":2},{"id":"GO:1903351","count":2}]},{"hash":"112775588960275499","title":"Neural development and axon fasciculation","description":"The cluster is strongestly linked to nervous system development and axon guidance (forebrain development, fasciculation of sensory neuron axon, multicellular organism development) with supporting roles in cell-matrix adhesion and broader tissue development. Additional signals in lipid transport, immune-related response, and osteoblast regulation may reflect shared developmental and remodeling processes, but neural development/axon connectivity is the clearest common theme.","confidence":"Medium","size":20,"edges":5,"triangles":0,"max_degree":3,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0097155","count":9},{"id":"GO:0030900","count":9},{"id":"GO:0032495","count":9},{"id":"GO:0007275","count":9},{"id":"GO:0007160","count":9}]},{"hash":"589575373159019984","title":"Golgi trafficking and cytoskeletal dynamics in cell division","description":"The top GO terms cluster around Golgi organization and Golgi-to-plasma membrane transport, endosome-to-Golgi trafficking, membrane addition at cytokinesis, and mitotic cell cycle, together with cytoskeletal/motor processes such as inner dynein arm assembly and stress fiber formation. This points to a cohesive theme of coordinating Golgi trafficking with cytoskeletal dynamics and motor activity during cell division and related cellular remodeling, with additional developmental contexts reflecting cytoskeletal roles. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":3},{"id":"GO:0007420","count":2},{"id":"GO:0007030","count":2},{"id":"GO:0007107","count":2},{"id":"GO:0034498","count":2}]},{"hash":"1428920355823256405","title":"Neural GPCR Signaling and Dopaminergic Transmission","description":"Most of the top terms point to signaling through G protein-coupled receptors, including GPCR signaling pathways that activate adenylyl cyclase, and to neuropeptide signaling and dopaminergic synaptic transmission. ERK1/ERK2 cascade regulation and Rho signaling further support a cohesive neural signaling module involved in synaptic communication and neuronal responses, with additional terms related to prostaglandin responses, xenobiotic sensing, and macrophage chemotaxis reflecting broader signaling cross-talk. Overall, the cluster appears to represent neural GPCR-mediated signaling and dopaminergic signaling.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":15},{"id":"GO:0070374","count":15},{"id":"GO:0019233","count":15},{"id":"GO:0007218","count":14},{"id":"GO:0071380","count":14}]},{"hash":"762703548029764279","title":"Platelet-vascular signaling and coagulation cluster","description":"Dominant terms cluster around platelet activation, vasoconstriction, blood coagulation and related signaling (Rho, ERK), plus inflammation (IL-1\u03b2 production) and neuropeptide signaling, suggesting a cohesive platelet\u2013vascular\u2013inflammatory signaling module; a single visual perception term seems incidental.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035025","count":19},{"id":"GO:0045907","count":19},{"id":"GO:0030168","count":19},{"id":"GO:0007601","count":19},{"id":"GO:0070374","count":19}]},{"hash":"1359201934590819123","title":"Virus-host Interaction and Signaling","description":"This cluster is dominated by GO terms related to viruses exploiting host machinery, including ESCRT-mediated budding and viral release, paired with host signaling and apoptosis terms (ERK cascade regulation and apoptotic process). The presence of translation and tRNA-related terms may reflect general cellular stress responses, but the core theme centers on virus-host interactions and associated cellular signaling/apoptotic pathways.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0039702","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0006450","count":1}]},{"hash":"573670015356359486","title":"Ubiquitination-linked innate immune signaling and pyroptosis","description":"The GO terms are dominated by ubiquitination, innate immune responses, and inflammatory cell death, including pyroptosis, TLR4 signaling, and IL-18 production, with xenophagy regulation. These collectively point to a cluster of proteins coordinating ubiquitin-mediated signaling that drives inflammatory responses and pyroptotic pathways, with some related apoptosis/autophagy regulation. The mitotic spindle term is less central but may reflect broader cellular stress responses; overall, the theme is ubiquitin-regulated innate immunity and pyroptosis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016567","count":11},{"id":"GO:1990001","count":10},{"id":"GO:0090307","count":10},{"id":"GO:0006915","count":10},{"id":"GO:0045087","count":10}]},{"hash":"1912718582322964520","title":"Ubiquitin-mediated proteolysis and circadian regulation","description":"This cluster is dominated by ubiquitin-dependent protein catabolic processes, including SCF-dependent proteasomal pathways and overall protein polyubiquitination, pointing to a core ubiquitin-proteasome system (UPS) function. The inclusion of regulation of circadian rhythm suggests clock protein turnover is a key shared mechanism, with additional terms like cadmium response and innate immunity reflecting broader proteostasis-linked stress responses. Overall, the central theme ties UPS activity to circadian regulation, with peripheral connections to stress and development.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0042752","count":7},{"id":"GO:0031146","count":7},{"id":"GO:0071276","count":6},{"id":"GO:0051260","count":6}]},{"hash":"285756937171380460","title":"Cytoskeleton dynamics and microtubule transport","description":"The top GO terms strongly point to cytoskeleton remodeling and movement driven by microtubules, along with regulation of Rho/GTPase signaling, which together suggest a cluster of proteins involved in cytoskeletal dynamics and intracellular transport. A few outlier terms (glucose transport, viral transport, spermatid development, mitotic cycle) exist but do not alter the core theme. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007018","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0043087","count":3},{"id":"GO:0015758","count":3},{"id":"GO:0070493","count":3}]},{"hash":"1107375487337359941","title":"Developmental immune-vascular signaling","description":"This cluster centers on developmental processes across immune and vascular tissues (B cell receptor signaling, thymus development, endothelial barrier establishment) with supporting roles for reproductive tissue development (uterus) and cytoskeletal signaling (Rho, actin branching) and ER-stress\u2013related translational regulation, suggesting a broad developmental signaling theme across these tissues.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050853","count":4},{"id":"GO:0090557","count":4},{"id":"GO:0048538","count":4},{"id":"GO:0060065","count":4},{"id":"GO:0045737","count":4}]},{"hash":"832476516809295690","title":"Neurite Outgrowth and Synaptic Function","description":"Top GO terms show a cohesive pattern around neural development and presynaptic activity, including axon extension, axonal fasciculation, axon guidance, and neurotransmitter loading into synaptic vesicles. While inflammatory signaling and some metabolic transport terms appear, they are less central to the cluster's core theme. Therefore, the label captures the dominant function of this group.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":2},{"id":"GO:0048846","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0071260","count":2}]},{"hash":"1535565655956535665","title":"Retroviral DNA Integration and Latency","description":"The cluster\u2019s top GO terms point to DNA transposition, DNA integration, establishment of proviral latency, and viral entry into the host nucleus, along with reverse-transcription-like processes (RNA-templated DNA synthesis) and host RNA silencing interactions. This combination strongly suggests a viral genome integration/latency program (retroviral\u2013like), with associated host-pathogen interactions such as entry and modulation of host defenses. A few terms about symbiont entry and apoptosis reflect related host\u2013symbiont/virus interactions but do not override the central theme of genome integration and latency.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":6},{"id":"GO:0015074","count":4},{"id":"GO:0075713","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0039651","count":3}]},{"hash":"970780432182007187","title":"Translation Machinery and Retroelement Integration","description":"The top GO terms show a strong emphasis on translation-related processes (translation, preinitiation complex formation, ribosome disassembly, translation reinitiation) together with DNA transposition, DNA integration, and proviral latency. This mix suggests the cluster includes proteins tied to ribosome/translation machinery and to retroelement or proviral integration processes, indicating two related but distinct functional themes, hence a label that captures both aspects.","confidence":"Medium","size":19,"edges":124,"triangles":405,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0015074","count":5},{"id":"GO:0007049","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0032790","count":3}]},{"hash":"1667875191372741","title":"RNA processing and transcription regulation","description":"The cluster is enriched for RNA-related processes (mRNA splicing, mRNA stability regulation in stress, and DNA-templated transcription) and ribosome biogenesis, pointing to a set of proteins involved in gene expression control at transcriptional and post-transcriptional levels. Other terms like protein sumoylation, inflammatory response, and metabolic transport may reflect regulatory cross-talk or multifunctionality, but the dominant theme is RNA processing and transcriptional regulation.","confidence":"Medium","size":19,"edges":56,"triangles":44,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0040015","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0010610","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0001963","count":2}]},{"hash":"290816580771722781","title":"Translation machinery and ribosome biogenesis","description":"Most of the top terms point to translation-related processes: translation, translational termination, and regulation of translational elongation, plus maturation of LSU rRNA, which ties to ribosome biogenesis. Selenocysteine incorporation further supports a link to specialized translation. While some terms reference biosynthetic or metabolic pathways (biotin, porphyrin, TCA), they appear ancillary; the core signal is protein synthesis machinery and ribosome maturation.","confidence":"High","size":19,"edges":107,"triangles":315,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0006415","count":3},{"id":"GO:0019878","count":3},{"id":"GO:0032869","count":3},{"id":"GO:0006782","count":3}]},{"hash":"178995223862390546","title":"Unknown","description":"The top GO terms span transcriptional regulation, hormone response, protein folding/ERAD, translation frameshifting, ciliogenesis, neural patterning signaling, and organelle targeting, with little cohesive overlap; this diversity suggests no single, interpretable cluster function or theme.","confidence":"","size":19,"edges":50,"triangles":18,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0071374","count":1},{"id":"GO:0032781","count":1},{"id":"GO:0051259","count":1},{"id":"GO:0070389","count":1}]},{"hash":"909436064899596978","title":"Chromatin remodeling and transcription regulation in development","description":"The cluster is dominated by GO terms for regulation of transcription by RNA polymerase II and chromatin remodeling, along with nucleosome positioning and heterochromatin maintenance. These indicate a shared role in shaping chromatin state to control gene expression during development, which aligns with embryonic cranial skeleton morphogenesis and hair cell differentiation. A few terms (mitochondrial large ribosomal subunit assembly, TRAMP-dependent tRNA surveillance) are less directly connected to chromatin, but do not outweigh the primary chromatin/transcription theme.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0045944","count":4},{"id":"GO:0043044","count":4},{"id":"GO:0048701","count":4},{"id":"GO:1902775","count":3},{"id":"GO:0071038","count":3}]},{"hash":"2083125132933487552","title":"Exosome Biogenesis and Endosomal Trafficking","description":"The cluster is enriched for vesicle-related processes\u2014multivesicular body assembly, endosome-to-lysosome transport, and exosomal secretion\u2014indicating a core function in vesicle biogenesis and release; other terms related to axon guidance and neuronal development may reflect downstream roles but vesicle trafficking/exosome production is dominant.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008283","count":4},{"id":"GO:0036258","count":4},{"id":"GO:0008333","count":4},{"id":"GO:1990182","count":4},{"id":"GO:0035385","count":4}]},{"hash":"827699752385016816","title":"Regulation of cell proliferation and signaling","description":"The top GO terms point to proliferative control and signaling, with positive regulation of cell division, smooth muscle cell proliferation, and the PI3K/AKT pathway; these together suggest a core function in promoting cell growth and growth-related signaling. A dsRNA response term appears but is less central to the cluster\u2019s main theme. Some obsolete terms are present but do not define the cluster\u2019s focus. Overall, the cluster appears to center on proliferative signaling regulation, with medium confidence. ","confidence":"Medium","size":19,"edges":5,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0045429","count":5},{"id":"GO:0051897","count":5},{"id":"GO:0048661","count":5},{"id":"GO:0071360","count":4}]},{"hash":"1755374553483604069","title":"Epigenetic Transcription Regulation","description":"Dominant GO terms reference histone H3 modifications (K4 dimethylation, K4 trimethylation) and regulation of histone acetylation, plus DNA-templated transcription, pointing to chromatin-level control of gene expression. A few other terms (metabolic or host interaction) are peripheral; overall the cluster centers on epigenetic regulation of transcription.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044648","count":2},{"id":"GO:1901674","count":2},{"id":"GO:2001040","count":2},{"id":"GO:0080182","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1418087121596609543","title":"Neuronal GPCR Signaling and Vascular Regulation","description":"This set is enriched for neuronal signaling and vascular regulation: neuropeptide signaling, regulation of synaptic transmission, GPCR\u2013cAMP/Rho pathways, and effects on blood pressure and vascular smooth muscle differentiation. The presence of energy-related terms is secondary to the dominant signaling theme, making this a cohesive label around neuronal GPCR signaling and vascular control.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019076","count":10},{"id":"GO:0051967","count":10},{"id":"GO:0010579","count":10},{"id":"GO:0035025","count":10},{"id":"GO:0045777","count":10}]},{"hash":"1242302563430000745","title":"Central metabolism and quinone biosynthesis","description":"This cluster groups proteins involved in core energy metabolism, including glycolysis, the TCA cycle, fatty acid beta-oxidation, and oxaloacetate handling, as well as biosynthesis of quinones (phylloquinone and menaquinone) that feed into respiration. The presence of multiple central carbon pathways alongside quinone biosynthetic terms suggests a shared role in energy production and redox balance, rather than a single specialized biosynthetic pathway. Some antibiotic biosynthesis and nutrient-response terms may reflect broader metabolic context but do not override the central metabolism theme.","confidence":"Medium","size":19,"edges":168,"triangles":920,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":10},{"id":"GO:0042372","count":10},{"id":"GO:0010124","count":10},{"id":"GO:0009234","count":10},{"id":"GO:0006635","count":10}]},{"hash":"742930066800270918","title":"DNA Replication, Transcription, and Repair","description":"This cluster shows strong enrichment for DNA replication, DNA-templated transcription, and DNA repair, indicating a core role in genome maintenance and gene expression; the other terms (developmental signaling, brain morphogenesis) appear secondary to this dominant DNA metabolism signal.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":16},{"id":"GO:0006351","count":16},{"id":"GO:0048701","count":15},{"id":"GO:0050852","count":15},{"id":"GO:0021697","count":15}]},{"hash":"1365508491124326941","title":"Viral DNA integration and proviral latency","description":"The top GO terms center on DNA integration, proviral latency, and related DNA processing (recombination, replication) and host-entry steps, pointing to processes involved in retroviral genome integration and maintenance as a provirus, with some related symbiont-host interaction terms.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":10},{"id":"GO:0006278","count":5},{"id":"GO:1903704","count":5},{"id":"GO:0075713","count":5},{"id":"GO:0006310","count":5}]},{"hash":"736238404939837126","title":"Developmental transcriptional regulators","description":"Most represented GO terms point to transcriptional activity (DNA-templated transcription; RNA polymerase II transcription) and to differentiation programs across several tissues (placenta, skeletal muscle, endocrine pancreas, lung vasculature, amacrine cells). This pattern fits a cluster of proteins that regulate gene expression during development and tissue differentiation, with some links to stress/hormone signaling. Hence Developmental transcriptional regulators.","confidence":"High","size":19,"edges":170,"triangles":952,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":15},{"id":"GO:0006366","count":10},{"id":"GO:0001892","count":8},{"id":"GO:0035914","count":8},{"id":"GO:0031018","count":8}]},{"hash":"2257797246093257277","title":"Neural development and transcription regulation","description":"Primarily reflects neural development programs and transcriptional/chromatin control. Recurrent terms cover neural cell fate specification in the spinal cord and cortex (interneurons, motor neurons, oligodendrocytes) and broad transcriptional activity (RNA polymerase II) with nucleosome positioning/density, suggesting coordinated gene regulation during differentiation. Some terms about bone and androgen signaling are present but peripheral.","confidence":"High","size":19,"edges":167,"triangles":904,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":10},{"id":"GO:0060766","count":7},{"id":"GO:0060303","count":7},{"id":"GO:0045668","count":7},{"id":"GO:0016584","count":6}]},{"hash":"1257583815110383530","title":"Innate Immune Activation and Inflammation","description":"This cluster is dominated by GO terms related to innate immune responses to fungal origin, including cellular response to molecule of fungal origin, complement activation via the lectin pathway, phagocytosis recognition, and basophil activation. Some developmental terms appear (cartilage condensation, metanephric morphogenesis), which may reflect shared signaling roles or annotation noise, but the overall signal points to immune activation and inflammatory processes.","confidence":"Medium","size":19,"edges":20,"triangles":6,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071226","count":11},{"id":"GO:0001502","count":10},{"id":"GO:0001867","count":10},{"id":"GO:0006910","count":9},{"id":"GO:0072287","count":9}]},{"hash":"80389703952542874","title":"Brain and dopaminergic neuron development","description":"Most terms point to neural development and neuron differentiation, particularly brain development and dopaminergic neuron differentiation, as well as subpallium and ventral spinal cord interneuron fate specification, suggesting the proteins in this cluster are involved in brain patterning and neuron formation. While a few terms (uterus development, bronchiole development) are non-neural and likely incidental, the dominant theme is neural development.","confidence":"High","size":19,"edges":67,"triangles":99,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0021882","count":19},{"id":"GO:0071542","count":19},{"id":"GO:0030901","count":19},{"id":"GO:1902870","count":19},{"id":"GO:0060065","count":19}]},{"hash":"2269168378158710678","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":3},{"id":"GO:1902042","count":3},{"id":"GO:0031639","count":3},{"id":"GO:0007160","count":2},{"id":"GO:1903265","count":2}]},{"hash":"2189350427878498096","title":"Unknown","description":"The top GO terms are a mix of mechanotransduction/cardiac signaling (response to muscle stretch, cellular response to mechanical stimulus, regulation of SA node cell action potential, SA node to atrial cardiac muscle cell communication) plus immune, apoptotic, and cell division terms (follicular dendritic cell differentiation, negative regulation of IL-12 production, hepatocyte apoptosis, spindle assembly). This broad, non-cohesive set provides no clear, single biological theme tying all proteins together, so a precise label isn\u2019t justifiable.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035994","count":3},{"id":"GO:0072660","count":3},{"id":"GO:0032088","count":3},{"id":"GO:0098907","count":3},{"id":"GO:0071260","count":3}]},{"hash":"864390524599385242","title":"PARP-mediated Telomere Maintenance","description":"The cluster is enriched for telomere-related GO terms (telomere maintenance, telomere capping, localization to telomeric regions, telomere length regulation) and protein ADP-ribosylation processes (auto- and poly-ADP-ribosylation), pointing to PARP-driven chromatin regulation at chromosome ends; a few terms (neuronal differentiation, spindle assembly) appear peripheral noise rather than core themes.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0051225","count":3},{"id":"GO:0070213","count":3},{"id":"GO:0070198","count":3}]},{"hash":"666596231331065209","title":"Nuclear RNA Splicing and Chromatin Regulation","description":"The top GO terms cluster around nuclear processes that regulate gene expression: mRNA splicing via the spliceosome, DNA integration and proviral latency (viral genome interactions), and histone acetylation, all pointing to chromatin state and transcription regulation. Development-related terms are present but secondary. This suggests a cohesive theme of RNA processing and chromatin modification rather than a single cytosolic pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0007275","count":2}]},{"hash":"1168949013021499671","title":"Heart development and muscle cytoskeleton","description":"The top GO terms point to cardiac morphogenesis (right atrium development) and Notch signaling in heart field cardioblasts, plus venous endothelial differentiation, indicating a cardiovascular development theme. Supporting terms like actin filament bundle assembly and spindle assembly suggest involvement in muscle structure and cell division components, together implying a cluster focused on heart formation and muscle architecture.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":6},{"id":"GO:0060843","count":5},{"id":"GO:0003213","count":5},{"id":"GO:0016567","count":5},{"id":"GO:0003270","count":5}]},{"hash":"1925981128085091559","title":"Neuropeptide signaling in thermoregulation and blood pressure","description":"The terms cluster around neuropeptide signaling, temperature response, thermogenesis, and cardiovascular regulation (vasopressin-mediated blood pressure, smooth muscle relaxation, dopamine uptake). Pain signaling and inflammatory regulation may be secondary links, but the core theme centers on neuropeptide-driven control of body temperature and vascular function, justifying this label.","confidence":"High","size":19,"edges":73,"triangles":78,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":15},{"id":"GO:0002024","count":15},{"id":"GO:0019233","count":15},{"id":"GO:0043950","count":13},{"id":"GO:0032651","count":13}]},{"hash":"799724191473811049","title":"Neural development and axon/dendrite growth","description":"The cluster is dominated by neural-related terms: hippocampus development, nervous system development, regulation of dendritic spine morphogenesis, and positive regulation of axon extension, all pointing to neural development and synaptic maturation. A few terms related to cell cycle and ubiquitin-mediated processes likely reflect shared cellular machinery rather than core function. Overall, the theme centers on neural development and axon/dendrite growth.","confidence":"High","size":19,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021766","count":4},{"id":"GO:0061001","count":3},{"id":"GO:0045773","count":3},{"id":"GO:0043525","count":3},{"id":"GO:0007399","count":3}]},{"hash":"639208508500098823","title":"Platelet activation and coagulation/fibrinolysis","description":"This cluster\u2019s top GO terms cluster around platelet activation, plasminogen activation, and fibrinolysis, with supporting signals for vasoconstriction and secretion, pointing to a shared role in hemostasis and vascular regulation. While a few terms (e.g., cell division, fructose response) are less cohesive, the dominant theme clearly aligns with coagulation and vascular control.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0050714","count":6},{"id":"GO:0031639","count":6},{"id":"GO:0045907","count":5},{"id":"GO:0051968","count":5},{"id":"GO:0051301","count":4}]},{"hash":"1298066328967151911","title":"Neuropeptide signaling and vascular regulation","description":"These terms converge on neuropeptide signaling and GPCR/cAMP pathways that regulate vascular tone, blood pressure (vasopressin, renin), dopamine signaling, and inflammatory chemokine production, pointing to a neuroendocrine signaling module.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":19},{"id":"GO:0032651","count":19},{"id":"GO:0007218","count":19},{"id":"GO:2000724","count":19},{"id":"GO:0090075","count":19}]},{"hash":"1258272297505145297","title":"Carbohydrate biosynthesis and glycosylation","description":"This cluster shows strong representation of carbohydrate metabolism (starch, sucrose, glycogen biosynthesis) and sugar-related responses (response to sorbitol/sucrose), plus glycosylation-related processes (protein glycosylation, GPI anchor biosynthesis, mannose-related pathways). The convergence on sugar building blocks and their attachment to proteins/lipids suggests a cohesive theme around carbohydrate biosynthesis and glycosylation pathways.","confidence":"Medium","size":19,"edges":79,"triangles":108,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0072708","count":9},{"id":"GO:0019252","count":9},{"id":"GO:0005985","count":9},{"id":"GO:0097502","count":9},{"id":"GO:0005978","count":9}]},{"hash":"256780827358355698","title":"Unknown","description":"The top terms span diverse processes (Notch signaling regulation, vasoconstriction, plasminogen activation, glutamatergic synaptic transmission, ventral spinal cord interneuron development/differentiation, R8 cell development, extracellular matrix cross-linking, gamma-delta T cell differentiation, and prostaglandin biosynthesis) with no single cohesive function, so there isn\u2019t a clear, specific theme to name the cluster beyond Unknown.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045746","count":12},{"id":"GO:0045907","count":10},{"id":"GO:0031639","count":10},{"id":"GO:0051968","count":10},{"id":"GO:0060579","count":9}]},{"hash":"701171785784769082","title":"Developmental signaling and differentiation with redox regulation","description":"These terms cluster around signaling pathways that govern development and differentiation in neural, immune, and muscle contexts, including prostaglandin biosynthesis, Notch signaling modulation, ventral spinal cord interneuron development, gamma-delta T cell differentiation, and skeletal muscle growth, with accompanying redox regulation. This suggests a broad role in development and cellular fate decisions rather than a single, cohesive pathway.","confidence":"Medium","size":19,"edges":6,"triangles":4,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001516","count":7},{"id":"GO:0098869","count":7},{"id":"GO:0032355","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0071672","count":6}]},{"hash":"1066698666244817858","title":"Unknown","description":"The top GO terms span antiviral/immune signaling, transcription and translation processes, and plant-like light/circadian signaling, plus mitochondrial dynamics, without a clear shared function across all proteins. This lack of a cohesive, single-theme function makes an Unknown label most appropriate. ","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045071","count":2},{"id":"GO:0035455","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0002181","count":1},{"id":"GO:0046632","count":1}]},{"hash":"1550578506446481464","title":"Retroviral DNA Integration and Host Entry","description":"The top GO terms cluster around viral genome integration and infection steps: DNA integration, DNA recombination, establishment of integrated proviral latency, and viral penetration into the host nucleus. There are additional terms related to symbiont-host interactions, but the dominant signal is retroviral integration and entry into host cells, which best explains the protein group. The absence of observed edges does not undermine this functional theme.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":7},{"id":"GO:0006310","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0039651","count":4}]},{"hash":"1555016684888259507","title":"Muscle development and sarcomere organization","description":"The top GO terms point to muscle-specific processes (sarcomere organization, muscle contraction, actin cytoskeleton remodeling) while also including broader developmental themes (multicellular organism development, nervous system/kidney development, ossification). The strongest, most coherent theme centers on muscle fiber formation and function, with supporting evidence of cytoskeletal dynamics and tissue morphogenesis, justifying a focus on muscle development and sarcomere organization.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0001822","count":4},{"id":"GO:0045214","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0007399","count":4}]},{"hash":"98605237063038110","title":"DNA transposition and proviral integration","description":"The top GO terms cluster around DNA transposition, DNA integration, RNA-templated DNA biosynthesis, and proviral latency, suggesting a common theme of mobile genetic elements (transposons/retroelements) and genome integration, with additional virus-host interaction aspects such as viral entry and host apoptosis signaling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0046718","count":4}]},{"hash":"1234586083661204984","title":"Neural and Cardiovascular GPCR Signaling","description":"The top GO terms point to GPCR-mediated signaling affecting neural communication (neuropeptide signaling, dopamine uptake in synaptic transmission) and cardiovascular regulation (blood pressure, vascular smooth muscle differentiation, muscle relaxation), with supporting cAMP signaling context. This suggests a cohesive cluster of proteins involved in GPCR-driven neural and cardiovascular signaling rather than disparate functions.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":19},{"id":"GO:0035025","count":19},{"id":"GO:0045777","count":19},{"id":"GO:0022900","count":19},{"id":"GO:0043950","count":17}]},{"hash":"1171806078996097242","title":"DNA repair and genome maintenance","description":"This cluster centers on DNA repair, replication, and damage response terms (nucleotide-excision repair, DNA-templated replication, DNA recombination, SOS response), indicating a connective theme of genome maintenance. A few unrelated terms (visual perception, cardiac morphogenesis, symbiont suppression) appear as noise rather than core signals. Edges are absent, but the dominant theme remains genome integrity and stress response.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":2},{"id":"GO:0006289","count":2},{"id":"GO:0006261","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0039657","count":2}]},{"hash":"707827305146735220","title":"Unknown","description":"The proteins in this cluster carry a highly diverse and seemingly unrelated set of GO terms, including defense against bacteria, ERK signaling, nitrate assimilation, cytolysis, visual perception and retina development, chromophore linkage, and various catabolic processes. This lack of a cohesive functional theme suggests no single interpretable cluster function can be assigned.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0019835","count":2},{"id":"GO:0007601","count":2}]},{"hash":"752395466416231291","title":"Autophagy- and ubiquitin-mediated turnover","description":"The cluster is driven by autophagy-related terms (mitophagy, ribophagy, autophagosome localization) and ubiquitin-related processes (ubiquitin-dependent endocytosis, monoubiquitination), suggesting a shared role in selective autophagy and protein degradation; a few other terms (DNA transposition, endothelial proliferation, regulation of T cell proliferation) are peripheral to the core theme.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0061734","count":2},{"id":"GO:0001935","count":2},{"id":"GO:0070086","count":1},{"id":"GO:0019089","count":1}]},{"hash":"1372890329166118352","title":"DNA Damage Response and Drug Efflux","description":"This cluster is dominated by GO terms for the SOS response and nucleotide-excision repair, indicating a DNA damage response. It also features antibiotic response and multiple xenobiotic/dye/drug transport terms (doxorubicin/daunorubicin transport, xenobiotic export), suggesting active drug efflux as part of resistance. Taken together, the proteins appear to function in DNA repair coupled with multidrug export under stress.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009432","count":4},{"id":"GO:0006289","count":3},{"id":"GO:0015734","count":2},{"id":"GO:0017004","count":2},{"id":"GO:0046677","count":2}]},{"hash":"1480520439421570736","title":"Unknown","description":"The listed GO terms cover diverse and largely unrelated processes (DNA transposition; symbiont entry into host cells; endothelial proliferation; mast cell activation and cytokine production; vestibular and inner ear development; vesicle formation). With zero edges/triangles, there is no evident shared pathway or theme linking these proteins, so a specific functional label cannot be confidently assigned.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0046718","count":2},{"id":"GO:0001935","count":2},{"id":"GO:1900625","count":2},{"id":"GO:0009444","count":2}]},{"hash":"1631991775184998597","title":"Proviral Integration and Latency","description":"The cluster\u2019s top GO terms center on DNA integration and establishment of integrated proviral latency, with additional signals of symbiont entry into host cells and host apoptosis activation, all indicating viral or endosymbiont genome integration and manipulation of host cells. Some other terms (synaptic potentiation, thyroid hormone metabolism) are less directly connected and may reflect multifunctional proteins, but the dominant theme is proviral integration and host interaction.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0098869","count":2},{"id":"GO:0043388","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0046718","count":2}]},{"hash":"2227950637451602471","title":"Ubiquitin-Mediated Innate Immune Signaling","description":"The cluster is strongly enriched for ubiquitination and innate immune-related terms (protein ubiquitination, NF-kappaB regulation, NOD2 signaling, pyroptotic response, innate immune response, apoptotic processes), suggesting proteins that regulate inflammatory signaling and apoptosis through ubiquitin tagging. Some cell-cycle terms appear but do not define the main theme.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":9},{"id":"GO:0032088","count":5},{"id":"GO:0070431","count":5},{"id":"GO:0070269","count":4},{"id":"GO:1990001","count":4}]},{"hash":"1954685332920495157","title":"Cell division and cytoskeletal dynamics","description":"Most top GO terms describe mitotic spindle assembly, cell division, and actin filament bundle assembly, with ubiquitination frequently regulating cell-cycle proteins. This points to a theme of mitosis and cytoskeletal remodeling; a few terms (neuronal differentiation, SNARE regulation) are less central. Overall, the cluster seems to reflect cell-cycle\u2013associated cytoskeletal dynamics.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0090307","count":2}]},{"hash":"2067132067728528767","title":"Unknown","description":"The GO terms span ubiquitin-dependent proteolysis, B cell signaling, cell-cycle and chromosome localization, plant hormone signaling, various development and muscle/locomotion processes, immune response, and renal function, indicating a highly heterogeneous set with no clear shared function or cohesive pathway linking the proteins. There are no edges, suggesting disparate annotations rather than a single functional cluster.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0050853","count":3},{"id":"GO:1900477","count":3},{"id":"GO:0035853","count":3},{"id":"GO:0009742","count":3}]},{"hash":"481023401943280410","title":"Ubiquitin-Dependent Protein Degradation","description":"This cluster is dominated by the GO term ubiquitin-dependent protein catabolic process (GO:0042787) with 16 of 19 proteins annotated to it, indicating a core function in ubiquitin-mediated proteolysis and protein turnover. While some other terms appear (e.g., regulatory processes and signaling), they are fewer and likely secondary or incidental annotations. The strong, central theme across the majority of members supports a concise label focused on ubiquitin-dependent degradation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0033151","count":8},{"id":"GO:2000620","count":8},{"id":"GO:1903762","count":8},{"id":"GO:1903265","count":8}]},{"hash":"60584574393290501","title":"DNA transposition and integration","description":"Top terms show DNA transposition and DNA integration as the dominant functions, suggesting a cluster of transposase-like or DNA mobility-related proteins. The other terms appear incidental, so the core theme is DNA movement; label with Medium confidence.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":4},{"id":"GO:0090305","count":3},{"id":"GO:0015074","count":3},{"id":"GO:2001240","count":2},{"id":"GO:0035994","count":2}]},{"hash":"186308251569499053","title":"Epigenetic Regulation of Development and EMT","description":"Most of the top terms point to histone methylation (H3K4, H3K27, H4K20) as epigenetic marks, alongside a term for positive regulation of epithelial-to-mesenchymal transition and palate development, implying a cluster of proteins involved in chromatin-based control of development and EMT. Some entries are obsolete or unrelated (e.g., renin-angiotensin system terms), suggesting annotation noise, but the core signal is histone modification tied to developmental regulation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034773","count":2},{"id":"GO:0098532","count":2},{"id":"GO:0080182","count":2},{"id":"GO:0010718","count":2},{"id":"GO:0060021","count":2}]},{"hash":"639902239679446335","title":"RNA Processing and Translational Regulation","description":"This cluster centers on spliceosome-driven mRNA splicing (cis and alternative), mRNA export and stability regulation, regulatory ncRNA-mediated gene silencing, and assembly of the eIF4F translation initiation complex, collectively indicating post-transcriptional control of gene expression.","confidence":"High","size":18,"edges":148,"triangles":739,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0035278","count":8},{"id":"GO:0045292","count":8},{"id":"GO:0048026","count":7},{"id":"GO:0075525","count":7},{"id":"GO:0031047","count":7}]},{"hash":"1480520347257687771","title":"Ribosome Biogenesis and rRNA Processing","description":"The top GO terms are dominated by ribosome-related processes: maturation of LSU-rRNA, preribosome and large subunit biogenesis, and cytosolic ribosome assembly, indicating a nucleolar/ribosome production module. While there are a few signals for DNA replication and cell-cycle processes, the strongest and most consistent theme across terms is ribosome biogenesis and rRNA maturation.","confidence":"High","size":18,"edges":135,"triangles":569,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0000902","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0006351","count":2}]},{"hash":"2011631382833006037","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":5,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070935","count":5},{"id":"GO:0033129","count":5},{"id":"GO:0010610","count":4},{"id":"GO:1904780","count":4},{"id":"GO:0071276","count":4}]},{"hash":"1410830752240251839","title":"Pyroptosis and innate immune apoptosis","description":"The cluster is dominated by GO terms for pyroptotic inflammatory response, innate immune response, and apoptotic process, with ubiquitination indicating regulatory control in these pathways. While there are also terms related to DNA replication and mitosis, the strongest signals point to inflammatory cell death and immune signaling as the core theme. Therefore, labeling it as pyroptosis and innate immune apoptosis best represents the central function of this group.","confidence":"Medium","size":18,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0070269","count":5},{"id":"GO:1990001","count":5},{"id":"GO:0090307","count":5},{"id":"GO:0016567","count":5},{"id":"GO:0006915","count":5}]},{"hash":"1637603887624131611","title":"RNA Processing and Translation with Stress Response","description":"The top GO terms cluster around spliceosome assembly, RNA processing and splicing, and translation, suggesting a core RNA metabolism module. Additional terms related to stress responses (response to antibiotic/cycloheximide) and innate immune signaling imply these RNA-related proteins may participate in broader stress-adaptive pathways. A single behavioral term appears as noise. Overall, the strongest shared theme is RNA processing/translation coupled with stress response, supporting this label.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000387","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0046898","count":1},{"id":"GO:0009870","count":1}]},{"hash":"520929477346781102","title":"Axon guidance and synaptic signaling","description":"The GO terms cluster around neuronal communication and connectivity: excitatory postsynaptic potential, regulation of synaptic vesicle endocytosis, and Roundabout signaling with axon guidance, plus ERK cascade involvement, suggesting roles in synaptic function and neural wiring. Some terms may be peripheral, but the dominant theme is neuronal signaling and pathfinding.","confidence":"High","size":18,"edges":22,"triangles":0,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":6},{"id":"GO:1900242","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0007286","count":5},{"id":"GO:0035690","count":5}]},{"hash":"290559641625670206","title":"Dermal Development Signaling","description":"The cluster is enriched for GO terms related to skin development and multicellular organism development, suggesting a developmental role in tissue formation. It also features regulation of GTPase activity and serine/threonine kinase signaling, including protein autophosphorylation, indicating coordinated signal transduction during growth and differentiation. Additional terms like mitotic cell cycle and apoptotic regulation reflect cell proliferation and remodeling during development; mRNA transport and hypoxia response may support stress and expression control in a developing tissue. Overall, these themes point to a focused function in skin-related development and signaling.","confidence":"High","size":18,"edges":43,"triangles":25,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":10},{"id":"GO:0000742","count":9},{"id":"GO:0031954","count":9},{"id":"GO:0071456","count":9},{"id":"GO:0071902","count":9}]},{"hash":"906301480159166354","title":"Mitochondrial energy production and apoptosis","description":"This cluster is dominated by mitochondrial-related processes: mitochondrial translation, ATP synthase assembly, and mitochondrial ATP production, together with intrinsic apoptotic signaling and cytochrome c release. The inclusion of terms related to cardiac muscle development suggests these proteins function in energy metabolism and apoptotic regulation within muscle tissue. ","confidence":"High","size":18,"edges":151,"triangles":785,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0032543","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0061179","count":1},{"id":"GO:0042775","count":1}]},{"hash":"48358474035001623","title":"Amino Acid Catabolism and Central Metabolism","description":"The dominant terms are metabolic: L-kynurenine and L-alanine catabolic processes, TCA cycle, and pyruvate biosynthesis, along with biosynthetic steps for cofactors like quinolinate (NAD) and protoporphyrinogen IX (heme). Together they point to amino acid turnover and core metabolism rather than a single signaling pathway. The Notch signaling term appears as a peripheral, likely noisy hit that doesn\u2019t define the cluster\u2019s primary function.","confidence":"Medium","size":18,"edges":108,"triangles":334,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019878","count":6},{"id":"GO:0097053","count":6},{"id":"GO:0042853","count":6},{"id":"GO:0007219","count":6},{"id":"GO:0006099","count":5}]},{"hash":"1758100350433104587","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":14,"triangles":7,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0009436","count":4},{"id":"GO:0034354","count":3},{"id":"GO:0051591","count":3},{"id":"GO:0097053","count":3},{"id":"GO:0042866","count":3}]},{"hash":"1376895724292937385","title":"Ubiquitin-Proteasome\u2013Mediated Proteolysis","description":"The cluster centers on ubiquitination and subsequent proteasomal degradation, with multiple terms for protein ubiquitination, ubiquitin-dependent catabolic processes, and SCF-dependent proteasomal degradation (core proteostasis functions). Additional terms about cadmium response and DNA damage signaling fit within stress-related regulation of proteolysis, supporting a proteostasis-focused cluster.","confidence":"High","size":18,"edges":4,"triangles":0,"max_degree":2,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0000209","count":12},{"id":"GO:0042787","count":11},{"id":"GO:0030433","count":9},{"id":"GO:0031146","count":9},{"id":"GO:0071276","count":8}]},{"hash":"1552330522905528483","title":"Autophagy-Related Protein Turnover","description":"The cluster is dominated by autophagy-related GO terms: mitophagy, ribophagy, and substrate localization to autophagosome, alongside ubiquitin-dependent processes such as endocytosis and protein monoubiquitination. While a few terms hint at general cellular processes (cell division, transcription), the autophagy and ubiquitin-proteasome themes suggest a cohesive function in selective protein degradation and turnover. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0070086","count":1},{"id":"GO:0019089","count":1},{"id":"GO:0006513","count":1}]},{"hash":"1544849735267942677","title":"Pyroptosis-driven innate immune signaling","description":"The label fits because the top terms include pyroptotic inflammatory response, innate immune response, IL-18 production, and TLR4 signaling, all pointing to a pathway of inflammatory cell death and innate immunity. Additional terms on ubiquitination and xenophagy suggest coordination of protein turnover and selective autophagy in immune responses, reinforcing a coherent theme around inflammatory signaling and pyroptosis, despite the presence of one term related to mitotic spindle assembly that may reflect broader cellular stress context. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070269","count":15},{"id":"GO:1990001","count":15},{"id":"GO:0090307","count":15},{"id":"GO:0045087","count":15},{"id":"GO:0016567","count":15}]},{"hash":"2176647619477872750","title":"Neuroendocrine control of blood pressure","description":"The GO terms point to neuropeptide signaling, dopaminergic synaptic regulation, vasopressin-mediated blood pressure control, and renin secretion, indicating a cohesive neuroendocrine network that modulates vascular function and hormonal signaling; some terms about inflammatory chemokine regulation appear but do not override the central theme.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":18},{"id":"GO:0032651","count":18},{"id":"GO:0007218","count":18},{"id":"GO:2000724","count":18},{"id":"GO:0090075","count":18}]},{"hash":"22265693339017070","title":"Innate antiviral response and autophagy","description":"Top GO terms converge on host defense against viruses and innate immunity, including innate immune response, defense response to virus, and regulation of NF-kappaB signaling. Additional terms point to cellular processes that modulate viral replication and trafficking, such as autophagy, ubiquitin-dependent protein catabolic process, and microtubule\u2013associated localization and dynamics. Collectively, the proteins appear to participate in antiviral defense and autophagic pathways that can restrict viral release and intracellular transport, consistent with the proposed label.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":10},{"id":"GO:0051607","count":10},{"id":"GO:0043123","count":8},{"id":"GO:0051092","count":8},{"id":"GO:0042787","count":8}]},{"hash":"395905905825399170","title":"Neural development signaling and plasticity","description":"This cluster is dominated by GO terms tied to neural development and signaling pathways, including Roundabout signaling, Smoothened signaling, nervous system development, prolactin signaling, and long-term neuronal synaptic plasticity. While a few terms touch on broader development (e.g., kidney development) or clearance processes, the strongest pattern centers on neural signaling and developmental processes, suggesting proteins that coordinate neural differentiation, signaling, and synaptic modulation.","confidence":"Medium","size":18,"edges":147,"triangles":726,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":14},{"id":"GO:0035385","count":14},{"id":"GO:0007399","count":14},{"id":"GO:0007224","count":13},{"id":"GO:0001822","count":13}]},{"hash":"889687489904271169","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0010587","count":2},{"id":"GO:0030260","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0039702","count":2}]},{"hash":"1328212129485281035","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090502","count":2},{"id":"GO:0001682","count":2},{"id":"GO:1904628","count":1},{"id":"GO:1900745","count":1},{"id":"GO:0044828","count":1}]},{"hash":"522119417808055309","title":"Neural migration and signaling","description":"Top GO terms point to neuronal migration (tangential migration SVZ to olfactory bulb, locomotory behavior) and signaling pathways (small GTPase signaling, Wnt signaling), along with endocytosis and ECM-related processes (collagen fibril organization). The combination suggests a developmental program focused on neural migration with supporting cytoskeletal, vesicle trafficking, and extracellular matrix interactions, rather than a single biochemical function. Confidence: Medium","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:1902042","count":4},{"id":"GO:0035641","count":4},{"id":"GO:0043652","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0022028","count":4}]},{"hash":"917847842666264053","title":"Neural development and signaling with ER-Golgi trafficking","description":"The cluster is enriched for brain/hippocampus development and neuronal signaling terms (brain development, hippocampus development, regulation of neuron apoptotic process, JNK cascade regulation, cellular response to mechanical stimulus), suggesting a core theme of neural development and signaling. In addition, multiple terms reference Golgi-ER trafficking (ER to Golgi vesicle transport, Golgi to plasma membrane protein transport), which are essential for neuronal differentiation and synaptic function. Some immune signaling terms appear but are less central to the dominant neural theme, implying those associations may reflect shared signaling components rather than a primary function. Overall, the set most coherently points to neural development and signaling with associated trafficking processes. ","confidence":"Medium","size":18,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046330","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0007420","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0010796","count":2}]},{"hash":"508495162908055322","title":"Developmental Signaling Pathways","description":"This cluster centers on proteins involved in signaling cascades that guide development across multiple tissues. GO terms highlight Roundabout, T cell receptor, Smoothened signaling, and axon guidance, alongside nervous system development, spermatid development, and bone ossification, suggesting a broad set of signaling components coordinating development and cell differentiation.","confidence":"High","size":18,"edges":70,"triangles":79,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035385","count":6},{"id":"GO:0050852","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0043552","count":5},{"id":"GO:0010796","count":5}]},{"hash":"834100691325121748","title":"Neural development and synaptic signaling","description":"These terms converge on neural development and signaling: multiple entries explicitly reference brain and nervous system development, plus regulation of synaptic vesicle exocytosis and MAPK pathways (ERK/JNK), which are key in neuronal differentiation, growth, and synaptic function. The presence of a mechanical stimulus response also aligns with neuronal sensitivity. Taken together, the proteins likely participate in neural development and synaptic communication.","confidence":"High","size":18,"edges":25,"triangles":6,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071260","count":7},{"id":"GO:0007420","count":7},{"id":"GO:0010796","count":6},{"id":"GO:0046330","count":6},{"id":"GO:0031384","count":6}]},{"hash":"1970179099958514323","title":"Neuronal development and GABAergic signaling","description":"The top GO terms point to neuronal development (hippocampus development), synaptic transmission (GABAergic), and cytoskeletal remodeling (filopodium assembly/regulation), plus apoptosis regulation in neurons. These collectively suggest a cluster of proteins involved in neuronal morphology and synaptic function. Some non-specific terms like spindle assembly/centrosome cycle appear, but the stronger neuronal-focused terms support the brain development and synaptic signaling theme.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":2},{"id":"GO:0007098","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0051489","count":2},{"id":"GO:0021766","count":2}]},{"hash":"676858917809768157","title":"Neural crest migration and axon guidance","description":"Dominant GO terms point to neural crest cell migration and nervous system development, including sympathetic ganglion formation, commissural axon guidance, and paranodal junction assembly, with craniofacial context (ear, retina vasculature). A single distant term (DNA integration) may be noise.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:1902378","count":1},{"id":"GO:0036486","count":1},{"id":"GO:0061549","count":1},{"id":"GO:0061299","count":1}]},{"hash":"881278526528785354","title":"Chromatin-associated developmental transcriptional regulators","description":"This cluster centers on transcriptional control and chromatin-related processes (DNA-templated transcription, negative regulation of transcription by RNA Pol II, establishment of protein localization to chromatin), with additional developmental signals (male gonad development, spermatogenesis, brain development). These patterns suggest proteins that regulate gene expression during development, particularly in reproductive and neural contexts. Some redox/mitochondrial-associated terms are present but do not outweigh the primary theme of developmental transcriptional regulation.","confidence":"Medium","size":18,"edges":6,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0007420","count":3},{"id":"GO:0007283","count":3}]},{"hash":"832336466641785104","title":"Neural development and axon guidance","description":"The terms cluster around neural development and connectivity: synapse assembly, multiple axon-guidance contexts (semaphorin-plexin signaling, branchiomotor and trigeminal neuron guidance), neural crest migration, and signaling pathways (VEGF receptor signaling and MAPK/ERK) that regulate growth and differentiation. This combination points to proteins involved in neural patterning, axon pathfinding, and synapse formation rather than general metabolism.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0048010","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0000187","count":4}]},{"hash":"313197446172961404","title":"Neuropeptide signaling and cardiovascular regulation","description":"The enriched GO terms center on neural and hormonal signaling (neuropeptide signaling, dopamine uptake regulation) and cardiovascular control (vasopressin-regulated blood pressure, renin secretion), pointing to neuroendocrine regulation of vascular function as the core cluster theme. A few terms touch inflammatory mediators, but the dominant pattern is neuropeptide signaling linked to cardiovascular physiology.","confidence":"High","size":18,"edges":7,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":18},{"id":"GO:0032651","count":18},{"id":"GO:0007218","count":18},{"id":"GO:2000724","count":18},{"id":"GO:0090075","count":18}]},{"hash":"1318892918198047077","title":"Developmental Gene Regulation","description":"The proteins seem enriched for developmental processes (brain, heart/ventricle, uterus development) and for gene expression control (regulatory ncRNA-mediated silencing, related regulatory terms). A few outliers (DNA transposition, obsolete terms) are present, but the dominant theme centers on development alongside gene regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":2},{"id":"GO:0090305","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0060065","count":1},{"id":"GO:0030263","count":1}]},{"hash":"850663786699877051","title":"Developmental and Immune Signaling","description":"This cluster combines multiple developmental processes (heart, multicellular organism, uterus development) with immune-related signaling (B cell receptor signaling, B cell affinity maturation, innate immune response) and signaling pathways (Rho signaling, cell adhesion), suggesting proteins involved in coordinating development with immune signaling and cytoskeletal regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0010863","count":4},{"id":"GO:0002344","count":4},{"id":"GO:0007155","count":4}]},{"hash":"2056490441135083929","title":"Zinc Ion Transport and Homeostasis","description":"The cluster is dominated by GO terms related to zinc handling: zinc ion import across the plasma membrane, detoxification of zinc ions, intracellular zinc ion homeostasis, and responses related to zinc ion status. This pattern suggests a cohesive function in zinc uptake and cellular zinc balance, with secondary signals like cadmium transport and limb development likely less central or incidental. Overall, the proteins appear to participate in maintaining zinc homeostasis and transport across membranes.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010165","count":2},{"id":"GO:0006830","count":1},{"id":"GO:0010312","count":1},{"id":"GO:0070574","count":1},{"id":"GO:0034224","count":1}]},{"hash":"1688045385147006044","title":"Ubiquitin-Proteasome Regulation of Cell Cycle","description":"The cluster is dominated by ubiquitin-dependent protein catabolic processes and SCF-dependent proteasomal degradation, with strong links to cell cycle\u2013related events such as mitotic G1 DNA damage checkpoint signaling and spindle assembly in meiosis. Additional terms point to circadian control and innate immunity, which can be influenced by ubiquitin signaling, suggesting the core theme is proteolysis-driven regulation of cell cycle and development processes.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0042752","count":10},{"id":"GO:0031146","count":8},{"id":"GO:0045087","count":8},{"id":"GO:0046785","count":7}]},{"hash":"221803061756388124","title":"DNA transposition and proviral integration","description":"The top GO terms cluster around DNA integration, transposition (including retrotransposition and DNA transposition), and the establishment of integrated proviral latency, with additional terms about viral entry into the host nucleus. This points to elements that move within or integrate into genomes (transposons, retroelements, proviruses) rather than typical cellular metabolism, justifying a label focused on transposition and integration processes.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":8},{"id":"GO:0075713","count":6},{"id":"GO:0032197","count":6},{"id":"GO:0075732","count":6},{"id":"GO:0039651","count":6}]},{"hash":"470133852045213411","title":"Immune signaling and cell adhesion","description":"This cluster is strongly enriched for immune-related signaling terms: innate immune response, T cell and B cell receptor signaling, and negative regulation of NK cell cytotoxicity, along with integrin-mediated signaling. While axonogenesis and circadian rhythm terms appear, the dominant pattern points to immune receptor signaling and cell adhesion pathways, suggesting these proteins function in immune communication and adhesion rather than strictly neuronal processes.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0060385","count":2},{"id":"GO:0042748","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0050852","count":2}]},{"hash":"1680464995638702728","title":"Transposable Elements and Proviral Integration","description":"The GO terms cluster around DNA/RNA transposition, retrotransposition, DNA integration, and proviral latency, with signals of host\u2013virus-like entry processes. This suggests proteins associated with mobile genetic elements and proviral integration events, rather than normal housekeeping functions. Thus, the label captures the core theme: transposable elements and proviral integration.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0031161","count":1},{"id":"GO:0046843","count":1},{"id":"GO:0046338","count":1},{"id":"GO:0075713","count":1}]},{"hash":"1545754354270546130","title":"Diverse developmental signaling and growth","description":"Top GO terms span cell migration, multiple signaling pathways (B cell receptor signaling, PDGFR signaling), and developmental processes (uterus development, fertilization) as well as growth and other miscellaneous functions. The terms are broad and heterogeneous with no single cohesive function dominating, suggesting a diverse cluster rather than a tight, unified role.","confidence":"Low","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":3},{"id":"GO:0071044","count":2},{"id":"GO:0050853","count":2},{"id":"GO:2000312","count":2},{"id":"GO:0018996","count":2}]},{"hash":"2027162302831869293","title":"Neural development and synapse signaling","description":"The cluster is dominated by GO terms related to nervous system development, synapse assembly, and PI3K signaling, pointing to roles in neural development and neural connectivity. While there are some broader developmental and signaling terms (face development, B cell receptor signaling), the strongest and most consistent theme is neuronal development and synaptic signaling.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":5},{"id":"GO:0007229","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0051965","count":4},{"id":"GO:0060324","count":3}]},{"hash":"1227787446576237661","title":"Cardiovascular development and ECM remodeling","description":"The terms cluster around heart formation and vascular differentiation (right atrium morphogenesis, venous endothelial differentiation, Notch signaling in heart field) with extracellular matrix remodeling (elastic fiber assembly, cell-matrix adhesion) and related vascular processes (vasoconstriction, coagulation). The complement term is a minor vascular-associated detail but overall the theme is cardiovascular development and extracellular matrix remodeling.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0060843","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0003213","count":4},{"id":"GO:0003270","count":4},{"id":"GO:0045907","count":4}]},{"hash":"1310882589188271787","title":"Adaptive Immune Response and Angiogenesis","description":"The top GO terms are dominated by adaptive immune processes (adaptive immune response, T cell proliferation, T cell costimulation) along with tissue remodeling activities (angiogenesis and collagen fibril organization). This points to proteins involved in immune activation coupled with vascular/tissue remodeling during responses, even though a few terms hint at other contexts like host-microbe interactions or neural development.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021772","count":2},{"id":"GO:0032516","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0042102","count":2}]},{"hash":"1266811247131306270","title":"Mesenchymal Development and Ossification","description":"The terms cluster around mesenchymal cell proliferation and differentiation (condensed mesenchymal cells; metanephric nephron tubule differentiation), ossification and bone maturation, and related processes such as fibroblast regulation, cell adhesion, vitamin K response, macrophage cytokine production, and hematopoietic stem cell migration to bone marrow. This points to a shared theme of mesenchymal lineage morphogenesis and bone-related development, with kidney development and immune/bone marrow interactions as supporting connections. Confidence: Medium","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":3},{"id":"GO:0033159","count":3},{"id":"GO:0071307","count":3},{"id":"GO:0007157","count":3},{"id":"GO:0072137","count":3}]},{"hash":"1995985316850310698","title":"RNA Polymerase II/III Preinitiation Complexes","description":"The GO terms center on transcription initiation and preinitiation complex assembly for RNA polymerases II and III, including promoter binding and start-site regulation, suggesting this cluster represents transcription initiation machinery rather than unrelated processes.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0090074","count":1},{"id":"GO:1904798","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0050434","count":1}]},{"hash":"2206331775881057238","title":"Post-transcriptional mRNA processing and silencing","description":"The proteins are linked to splicing (positive/alternative splicing via spliceosome), mRNA export, stress-related mRNA stability, and RNA silencing (miRNA and ncRNA-mediated). Together, these terms point to a cohesive cluster focused on post-transcriptional regulation of gene expression, including RNA processing, export, and translation control. Some terms reflect broader developmental contexts, but the core theme remains RNA-level regulation.","confidence":"High","size":17,"edges":30,"triangles":17,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":5},{"id":"GO:0031047","count":4},{"id":"GO:0001825","count":4},{"id":"GO:0075525","count":3},{"id":"GO:0035278","count":3}]},{"hash":"1305680247375183902","title":"Ribosome Biogenesis and Translation","description":"Most top GO terms are related to translation and ribosome assembly (translation, maturation of SSU-rRNA, large subunit assembly). A few terms touch on meiosis and DNA repair, but these appear as peripheral associations; the core functional signal is RNA/protein synthesis machinery and ribosome biogenesis.","confidence":"Medium","size":17,"edges":75,"triangles":192,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0042493","count":4},{"id":"GO:0000462","count":3},{"id":"GO:0000027","count":3},{"id":"GO:0010569","count":3}]},{"hash":"367685728041177321","title":"RNA processing and protein quality control","description":"This cluster combines GO terms pointing to RNA processing (regulation of alternative splicing, translational frameshifting) with protein homeostasis processes (chaperone-assisted refolding, ERAD, oligomerization, ATP-dependent activity). The mix suggests a broad theme around post-transcriptional regulation and maintenance of protein quality, rather than a single, tightly defined function. Some terms are obsolete or pathway-specific outliers, which may reflect annotation noise or broader regulatory connections. ","confidence":"Medium","size":17,"edges":39,"triangles":19,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":3},{"id":"GO:0071374","count":2},{"id":"GO:0032781","count":2},{"id":"GO:0051259","count":2},{"id":"GO:0070389","count":2}]},{"hash":"2009061910476002347","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0061053","count":2},{"id":"GO:1904667","count":2}]},{"hash":"1985537936956733414","title":"Neurodevelopment and Synaptic Regulation","description":"The top GO terms point to brain development and synaptic function, including cerebellar cortex development, excitatory postsynaptic potential, and regulation of synaptic plasticity, plus environmental enrichment responses that relate to neuronal plasticity. While a few terms touch on non-neural processes, the dominant signal suggests neural development and synaptic signaling as the cluster\u2019s theme.","confidence":"Medium","size":17,"edges":17,"triangles":6,"max_degree":11,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0090648","count":16},{"id":"GO:0021695","count":16},{"id":"GO:0097350","count":16},{"id":"GO:0060079","count":16},{"id":"GO:0090188","count":16}]},{"hash":"116389770484659883","title":"Translation Core and Stress Response","description":"The cluster shows strong ties to translation and aminoacylation (methionyl- and leucyl-tRNA aminoacylation, translation), suggesting core protein synthesis machinery. Additional terms point to stress and redox-related processes (cold/ethanol response, superoxide removal) and nitrogen metabolism (nitrate assimilation, NO biosynthesis), indicating accompanying metabolic/adaptive roles.","confidence":"Medium","size":17,"edges":13,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0006431","count":2},{"id":"GO:0006429","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0042128","count":2}]},{"hash":"603349903767925096","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":134,"triangles":651,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006099","count":6},{"id":"GO:0097053","count":5},{"id":"GO:0042853","count":5},{"id":"GO:0007219","count":5},{"id":"GO:0033512","count":4}]},{"hash":"1507381099333652049","title":"Embryonic and organ development","description":"This cluster features GO terms across multiple tissues (pituitary gland, pancreas, eye, cerebellum, skeletal muscle, uterus) and broad developmental processes including multicellular organism development. The inclusion of negative regulation of transcription by RNA polymerase II suggests regulatory roles during development. Together, these terms point to a general developmental program rather than a single tissue-specific pathway.","confidence":"Medium","size":17,"edges":33,"triangles":10,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0021983","count":7},{"id":"GO:0048701","count":6},{"id":"GO:0031016","count":5},{"id":"GO:0043010","count":5}]},{"hash":"1399294775156809007","title":"Cell Cycle and DNA Replication with Stress Response","description":"The dominant GO terms point to DNA-templated transcription, DNA replication, mitotic cell cycle, and cell division, indicating a core role in genome maintenance and proliferation. Additional terms for protein folding in the ER and peroxisome matrix import reflect supporting quality-control and trafficking processes, while cellular response to oxidative stress suggests stress management during proliferation. Together, these features define a module centered on cell cycle progression and DNA replication with associated stress-response and protein handling activities.","confidence":"High","size":17,"edges":8,"triangles":5,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034599","count":8},{"id":"GO:0001824","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0043388","count":6},{"id":"GO:0051301","count":6}]},{"hash":"1301807777548068808","title":"Embryonic organogenesis and morphogenesis","description":"The proteins cluster shows strong enrichment for multiple organ development and morphogenesis terms (pituitary gland, endocrine pancreas, male gonad, neural crest migration, cochlea morphogenesis, ureteric bud morphogenesis, embryonic digestive tract morphogenesis, spleen development) plus regulatory processes such as transcriptional regulation, indicating a broad program of embryonic organogenesis rather than a single tissue-specific function.","confidence":"High","size":17,"edges":8,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":9},{"id":"GO:0031018","count":8},{"id":"GO:0008584","count":8},{"id":"GO:0000122","count":7},{"id":"GO:0001755","count":7}]},{"hash":"1658281423228356396","title":"Embryonic Morphogenesis and Transcription Regulation","description":"The top GO terms cluster around embryonic organ morphogenesis (eye, brain, cranial skeleton, lung) and development, with concurrent references to transcription by and negative regulation of RNA polymerase II, suggesting proteins involved in developmental morphogenesis and transcriptional control during embryogenesis.","confidence":"Medium","size":17,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060441","count":11},{"id":"GO:0006366","count":11},{"id":"GO:0048048","count":11},{"id":"GO:0043010","count":11},{"id":"GO:0048701","count":10}]},{"hash":"1584596500194709094","title":"Proviral integration and DNA transposition","description":"This cluster is dominated by GO terms related to DNA integration, recombination, transposition, and reverse transcription, plus proviral latency and viral entry into the host nucleus. The shared theme is mobile genetic elements (viruses/retrotransposons) integrating into and manipulating the host genome, with some related host interaction processes. Confidence in this label is High.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0006310","count":3},{"id":"GO:0006313","count":3},{"id":"GO:0006278","count":2},{"id":"GO:1903704","count":2}]},{"hash":"1726395787368757160","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0006313","count":3},{"id":"GO:0032197","count":2}]},{"hash":"888406850017967649","title":"Cytoskeleton Organization and Cell Polarity","description":"GO terms emphasize actin filament bundle assembly, spindle assembly, and establishment of epithelial cell polarity, pointing to a coherent theme of cytoskeletal organization and polarity regulation (with some less informative/obsolete terms). ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0098907","count":8},{"id":"GO:0007205","count":8},{"id":"GO:0051225","count":7},{"id":"GO:0035994","count":7},{"id":"GO:0035544","count":7}]},{"hash":"912940682873657309","title":"Neural signaling and sensory perception","description":"This cluster is driven by terms related to sensory processing (pain, visual perception, visual learning) and neural signaling (dopaminergic transmission, ERK cascade, protein phosphorylation), suggesting a cohesive theme of nervous system communication, perception, and plasticity. Some terms also touch on inflammatory/modulatory signaling, which can intersect with sensory pathways.","confidence":"High","size":17,"edges":119,"triangles":479,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":13},{"id":"GO:0071380","count":12},{"id":"GO:0010759","count":12},{"id":"GO:0071502","count":12},{"id":"GO:0001963","count":12}]},{"hash":"2222017036850810644","title":"Mechanotransduction and cytoskeletal organization","description":"The top GO terms cluster around cellular response to mechanical stimulus, actin filament bundle assembly, spindle assembly, and epithelial polarity, all related to how cells sense and respond to mechanical cues and organize their cytoskeleton. This suggests a coherent theme of mechanosensing and cytoskeleton remodeling.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071260","count":8},{"id":"GO:0051225","count":6},{"id":"GO:0035994","count":6},{"id":"GO:0035544","count":6},{"id":"GO:0051017","count":6}]},{"hash":"1501996379744928514","title":"Neuronal Synapse Formation and Axon Guidance","description":"The cluster\u2019s strongest signals are neural: synapse assembly, neurotransmitter secretion, and axon extension involved in axon guidance, indicating proteins involved in establishing neural connectivity. Other terms touch on cytoskeletal dynamics and neuronal chemotaxis regulation, which align with axon pathfinding and synaptic remodeling, with some oxidant detoxification terms reflecting general neuronal stress responses. Overall, the functions converge on neuronal signaling and connectivity.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0007269","count":7},{"id":"GO:0098869","count":6},{"id":"GO:0019800","count":6},{"id":"GO:0007416","count":6}]},{"hash":"1403408308289186542","title":"Brain and forebrain development","description":"The cluster shows strong enrichment for brain-related developmental terms (pituitary gland development, cerebral cortex development, habenula development, forebrain patterning and boundary formation) along with general multicellular organism development and regulatory functions, indicating a coherent theme of neural development and brain region patterning.","confidence":"High","size":17,"edges":30,"triangles":6,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":9},{"id":"GO:0051573","count":7},{"id":"GO:0021987","count":7},{"id":"GO:2000288","count":5},{"id":"GO:0021918","count":5}]},{"hash":"488586656273539592","title":"Wnt-regulated adipogenesis and myogenesis","description":"GO terms indicate involvement in fat cell differentiation, myoblast proliferation, and Wnt signaling, with a note on mechanotransduction. This suggests a shared theme of lineage specification and development of adipose and muscle tissues controlled by Wnt signaling and mechanical cues, making the label a concise, representative umbrella for the cluster.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010745","count":2},{"id":"GO:0016049","count":2},{"id":"GO:0045444","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0016055","count":2}]},{"hash":"2305243897370614527","title":"Unknown","description":"The terms span plant-specific processes (photosynthesis, cytokinin signaling) alongside cell-cycle and development terms (mitotic regulation, centrosome maintenance, atrial septum development) and even obsolete annotations, with no clear shared function across the cluster. This mix suggests no coherent single theme to assign a specific label.","confidence":"","size":17,"edges":15,"triangles":1,"max_degree":13,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0051291","count":12},{"id":"GO:1903646","count":11},{"id":"GO:2001162","count":11},{"id":"GO:0071276","count":11},{"id":"GO:0015979","count":11}]},{"hash":"2119054875636523058","title":"Neural development and axon guidance signaling","description":"This cluster is dominated by GO terms related to neural development and axon guidance (axon extension and commissural neuron guidance; sympathetic ganglion development), with supporting growth factor signaling (PDGF and HGF receptor pathways) and developmental patterning (Hedgehog pathway) and vascular morphogenesis (coronary artery morphogenesis). While complement activation appears among the terms, the core theme centers on neural development and axon guidance coupled with developmental signaling. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0048632","count":7},{"id":"GO:0048846","count":7},{"id":"GO:0060982","count":7},{"id":"GO:0045880","count":7}]},{"hash":"1824853791535510094","title":"Embryonic organogenesis","description":"These proteins map to a broad set of embryonic development and morphogenesis processes across multiple organs (eye, brain, lung, bone). The GO terms cluster around organogenesis and tissue patterning rather than a single tissue, suggesting a general developmental role. Therefore Embryonic organogenesis best captures the shared function.","confidence":"High","size":17,"edges":131,"triangles":606,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0060441","count":7},{"id":"GO:0048048","count":7},{"id":"GO:0043010","count":7},{"id":"GO:0002076","count":7}]},{"hash":"1432302895819215118","title":"Glycan and lipid biosynthesis","description":"The cluster centers on biosynthetic processes for carbohydrates and glycoconjugates (glycogen, starch, sucrose; GPI anchors; protein glycosylation) and for lipids (phospholipids), with an additional note of sugar-related responses. This suggests a cohesive theme around synthesis of glycans, glycoconjugates, and lipid components rather than a single precise pathway.","confidence":"Medium","size":17,"edges":38,"triangles":19,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":12},{"id":"GO:0072708","count":11},{"id":"GO:0019252","count":11},{"id":"GO:0005985","count":11},{"id":"GO:0097502","count":11}]},{"hash":"189293361603515137","title":"Biosynthesis and methylation pathways","description":"The proteins cluster around diverse biosynthetic processes (antibiotic, biotin, sterol, polyamine, phosphatidylcholine) and include methylation-related activities (peptidyl methylation, arginine methylation, and mRNA capping), indicating a theme of metabolic biosynthesis linked with methylation modifications. Some terms appear as noise (e.g., response to cocaine, obsolete aging), but the core signal is biosynthetic and methylation functions.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0009102","count":7},{"id":"GO:0001300","count":5},{"id":"GO:0042220","count":5},{"id":"GO:0006370","count":5}]},{"hash":"258259602401233860","title":"Unknown","description":"The top GO terms cover a wide array of unrelated processes, including RNA processing (mRNA capping, tRNA wobble modification, arginine methylation), diverse chemical responses (to cocaine, to amines, to tellurium), metabolism (selenium compounds, chlorophyll biosynthesis), and plant-specific processes (nodulation). With no clear, shared function tying the proteins together and no interacting edges, there isn\u2019t a coherent cluster theme to name beyond Unknown.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":7},{"id":"GO:0006370","count":7},{"id":"GO:0019919","count":7},{"id":"GO:0014075","count":7},{"id":"GO:0001887","count":7}]},{"hash":"2018912694923364711","title":"Carbohydrate and glycoprotein biosynthesis","description":"Based on the GO terms, the cluster is enriched for carbohydrate biosynthesis (starch, sucrose, glycogen) and glycosylation-related pathways (GPI anchor biosynthesis, protein glycosylation in ER), with additional signals for phospholipid biosynthesis and bacillithiol production. This combination points to a common theme of building carbohydrate-containing and glycoconjugate components of the cell surface and membranes, rather than catabolic or signaling roles. ","confidence":"High","size":17,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072708","count":3},{"id":"GO:0019252","count":3},{"id":"GO:0005985","count":3},{"id":"GO:0097502","count":3},{"id":"GO:0005978","count":3}]},{"hash":"1076281854882451168","title":"Embryogenesis and hematopoietic differentiation","description":"Based on the GO terms, the proteins are enriched for embryonic development processes (in utero embryonic development, primitive streak formation) and for hematopoietic lineage differentiation (granulocyte, erythrocyte, and megakaryocyte differentiation). There is also involvement in transcriptional regulation during development (RNA Pol II). Together, this suggests a cluster of factors coordinating early development with blood cell lineage specification.","confidence":"Medium","size":17,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0021983","count":6},{"id":"GO:0030851","count":5},{"id":"GO:0045648","count":5},{"id":"GO:0090009","count":5}]},{"hash":"1147523643173978728","title":"Osmotic Stress and Carbohydrate/Thiols Biosynthesis","description":"The terms point to osmotic stress response (water deprivation, sorbitol) and a coordinated set of biosynthetic processes for carbohydrates (starch, glycogen, glycolipids) and thiol-based redox protectants (mycothiol, bacillithiol), with some glycosylation entries. This suggests a bacterial stress-adaptation module linking osmoprotection to carbohydrate and thiol biosynthesis/glycosylation.","confidence":"Medium","size":17,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032092","count":4},{"id":"GO:0019252","count":4},{"id":"GO:0097502","count":4},{"id":"GO:0009414","count":4},{"id":"GO:0010125","count":4}]},{"hash":"392794425183910103","title":"Embryonic vascular and heart morphogenesis","description":"The cluster centers on vascular development and heart formation, with terms like smooth muscle cell migration, endothelial chemotaxis, plasminogen activation, endocardial differentiation, and Notch signaling regulation, plus blood coagulation and broader embryonic morphogenesis. This suggests proteins involved in cardiovascular development and embryonic tissue remodeling, despite a few broader developmental terms that may reflect shared pathways. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0014909","count":8},{"id":"GO:0055114","count":8},{"id":"GO:2001027","count":8},{"id":"GO:0031639","count":8},{"id":"GO:0045746","count":8}]},{"hash":"404378581467464760","title":"ECM remodeling and vascular regulation","description":"The top terms cluster around extracellular matrix components and remodeling (elastic fiber assembly, cell-matrix adhesion), proteolysis (plasminogen activation), and vascular biology (vasoconstriction, angiogenesis, vascular permeability). Immune-related terms (complement activation, recognition of apoptotic cells) and coagulation-linked processes also appear, suggesting a broader theme of ECM-modulated vascular and immune regulation rather than a single pathway. The absence of edges may reflect functional rather than physical connections among proteins. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0045907","count":8},{"id":"GO:0051968","count":8},{"id":"GO:0031639","count":8},{"id":"GO:0007160","count":7}]},{"hash":"243133725259282219","title":"Unknown","description":"The GO terms are highly diverse, spanning signaling (cAMP response, phosphatidylinositol signaling, GTPase regulation), multiple developmental processes (adult cuticle development, adenohypophysis morphogenesis, thyroid hormone metabolism, branching morphogenesis, substantia nigra development), and oxidative stress (hydrogen peroxide and superoxide generation). There are no edges or connections between proteins, suggesting no cohesive functional theme tying the cluster together. Therefore, I cannot assign a specific, representative function label beyond Unknown.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051591","count":2},{"id":"GO:0008365","count":2},{"id":"GO:0048855","count":2},{"id":"GO:0042403","count":2},{"id":"GO:0050665","count":2}]},{"hash":"668201144348798524","title":"Neuronal signaling and sensory perception","description":"This cluster centers on neural signaling and sensory processing, highlighted by dopaminergic synaptic transmission, visual perception and learning, pain perception, and cocaine-related behavioral responses, along with ERK signaling and protein phosphorylation. While a few terms (heart development, macrophage chemotaxis, prostaglandin response) are peripheral, the dominant theme is neural communication and perception.","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":10},{"id":"GO:0071380","count":9},{"id":"GO:0010759","count":9},{"id":"GO:0001963","count":9},{"id":"GO:0007507","count":9}]},{"hash":"2020740318426273315","title":"Neurodevelopment and ERK signaling","description":"The top terms are dominated by nervous system development (forebrain morphogenesis, nervous system development, left/right symmetry) and signaling activities (positive regulation of ERK1/2 cascade, positive regulation of GTPase activity), suggesting a cluster focused on neural development and ERK-driven signaling. A kidney development term appears but is less central to the overall theme. ","confidence":"High","size":17,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048853","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0007368","count":2},{"id":"GO:0001656","count":2},{"id":"GO:0043547","count":2}]},{"hash":"531180696082818943","title":"RNA processing and ubiquitination regulators","description":"The terms show strong signals for RNA metabolism (mRNA processing, RNA splicing) and protein ubiquitination, with additional hints of transcriptional regulation. These together point to clusters of proteins that influence gene expression through RNA processing and ubiquitin-mediated regulation, though a minority of terms (e.g., innate immune signaling, developmental) may be less representative. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903206","count":2},{"id":"GO:0034260","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0003283","count":2},{"id":"GO:0006977","count":2}]},{"hash":"1877373742974283270","title":"Immune and vascular development","description":"Top terms show a blend of immune activation (positive regulation of T cell proliferation, T cell costimulation) and vascular/valvular morphogenesis (aorta, venous vessel, and valve morphogenesis), suggesting proteins that coordinate immune signaling with vascular development or remodeling. Some terms are less connected (e.g., adult walking behavior), but the dominant theme appears to be immune-related regulation paired with vascular development. This justifies the label \"Immune and vascular development.\" ","confidence":"Medium","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042102","count":4},{"id":"GO:0072218","count":3},{"id":"GO:0021654","count":3},{"id":"GO:1903849","count":3},{"id":"GO:1900025","count":3}]},{"hash":"1331680076601712637","title":"Developmental Morphogenesis and Neural Connectivity","description":"GO terms cluster around tissue morphogenesis (eye, skin, smooth muscle) and neural wiring (axonal fasciculation, synapse assembly), with both positive and negative regulation of synaptic growth, suggesting roles in developmental tissue shaping and neural connectivity rather than a single pathway.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048593","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0043589","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0048671","count":2}]},{"hash":"520072156553477267","title":"Plant far-red light signaling and circadian regulation","description":"The dominant GO terms are far-red light signaling pathway, red/far-red light phototransduction, and positive regulation of circadian rhythm, pointing to proteins involved in plant light perception and circadian control. Some unrelated terms appear (e.g., metabolism, apoptosis, cardiac processes), likely due to broad annotations, but the core cluster theme aligns with plant light signaling and circadian regulation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010018","count":3},{"id":"GO:0042753","count":3},{"id":"GO:0009585","count":3},{"id":"GO:0097011","count":2},{"id":"GO:0007605","count":2}]},{"hash":"1794918273829744740","title":"Axon Guidance and Paranode Localization","description":"The cluster\u2019s top GO terms cluster around neuron projection guidance and nerve structure (sympathetic and branchiomotor axon guidance, trigeminal nerve organization, and semaphorin-plexin signaling) as well as protein localization to the paranode region of axons, indicating a cohesive theme of axon guidance and nerve architecture. Some terms like fibrinolysis and platelet activation appear, but the dominant signal is guidance and structural organization of neural processes.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0097491","count":2},{"id":"GO:0021785","count":2},{"id":"GO:0002175","count":2},{"id":"GO:0042730","count":2}]},{"hash":"1564462653127529839","title":"Neuronal synapse assembly and vesicle trafficking","description":"This cluster centers on neuronal communication, with GO terms for synapse assembly, excitatory postsynaptic potential regulation, endocytic recycling, and intralumenal vesicle formation, plus behavior-related terms (grooming, vocalization, social behavior). The convergence on synaptic organization and vesicle trafficking suggests a cohesive theme of neuronal synapse formation and vesicle recycling driving neural signaling and behavior.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000821","count":3},{"id":"GO:0071625","count":3},{"id":"GO:0035176","count":3},{"id":"GO:1990126","count":2},{"id":"GO:0035750","count":2}]},{"hash":"582993325010744266","title":"Transcription elongation and chromatin regulation","description":"The cluster is dominated by GO terms related to transcription elongation by RNA polymerase II and I, with positive regulation of elongation, plus histone modifications such as H2B ubiquitination and H3K4 methylation. Although a minority of terms touch developmental processes (endodermal fate, stem cell maintenance) these likely reflect shared regulatory genes that influence transcription and chromatin state across contexts. Thus the label emphasizes the central functions linking transcription elongation and chromatin regulation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006368","count":4},{"id":"GO:2001209","count":3},{"id":"GO:0032968","count":3},{"id":"GO:2001173","count":3},{"id":"GO:0080182","count":3}]},{"hash":"1939593674419588214","title":"GPCR Signaling and Energy Metabolism","description":"The top terms cluster around GPCR-based signaling (adenylate cyclase\u2013activating pathways) and related signal transduction (Rho), with strong links to energy and cardiovascular regulation (electron transport chain, blood pressure, thermogenesis). Sensory perception (vision, pain) and inflammatory regulation (IL-1\u03b2) are present but appear as broader downstream associations. Taken together, the cluster centers on signaling pathways that modulate cellular activity and energy/metabolic balance, with cardiovascular and thermogenic implications.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":15},{"id":"GO:0035025","count":15},{"id":"GO:0045777","count":15},{"id":"GO:0022900","count":15},{"id":"GO:0071502","count":13}]},{"hash":"3481345089153067","title":"Unknown","description":"The GO terms are diverse and span transcription regulation, endosomal trafficking, synaptic signaling, calcium-channel regulation, histone modification, receptor recycling, ciliogenesis, ubiquitination, and mitotic cell cycle, with no single dominant function or pathway tying them together. This prevents a cohesive, specific label. ","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0051036","count":1},{"id":"GO:0035249","count":1},{"id":"GO:0060316","count":1},{"id":"GO:0035023","count":1}]},{"hash":"2289837479961440602","title":"Insect neural signaling and behavior","description":"This cluster centers on neuronal communication and behavioral responses, with terms like octopamine signaling, regulation of glutamate receptor signaling, and behavioral responses to ethanol, plus mating-related behavior. While a few terms are unrelated or obsolete, the dominant theme points to neurobehavioral regulation in insects. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048265","count":2},{"id":"GO:2001172","count":1},{"id":"GO:1903212","count":1},{"id":"GO:0090180","count":1},{"id":"GO:0048047","count":1}]},{"hash":"1181134392930439983","title":"Ubiquitin-Proteasome\u2013Mediated Proteolysis","description":"The cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes, polyubiquitination (including K48- and K6-linked ubiquitination), and SCF-dependent proteasomal degradation, which together point to a core module of ubiquitin-tagging and proteasome-driven protein turnover. Additional terms on histone catabolic processes and oxidative-stress\u2013related neuronal apoptosis suggest ancillary links to chromatin dynamics and stress responses, but the central theme remains ubiquitin-proteasome\u2013mediated degradation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0000209","count":9},{"id":"GO:0085020","count":8},{"id":"GO:1903265","count":8},{"id":"GO:0036205","count":8}]},{"hash":"1975463039174176280","title":"Unknown","description":"The top GO terms span very disparate processes (symbiont entry into host cell, various developmental processes, proteolysis, endothelial cell migration, detoxification, chlorophyll catabolic process, poly-hydroxybutyrate biosynthesis, and redox/oxidation-reduction). There isn\u2019t a clear shared function or pathway linking these proteins, so a cohesive, specific label isn\u2019t supported by the data.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":4},{"id":"GO:0060021","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0043542","count":3},{"id":"GO:0098869","count":3}]},{"hash":"913679832453325348","title":"Unknown","description":"The GO terms for this cluster are highly heterogeneous and several are labeled obsolete, with no single, cohesive biological function emerging. Terms span sensory perception of sound, keratinocyte proliferation regulation, GPCR signaling, cytokine production, mating plug formation, and various salvage pathways, indicating a mixture of disparate processes rather than a unified function. Therefore, I cannot assign a meaningful, specific label to this cluster.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0051262","count":2},{"id":"GO:0010838","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0050663","count":2}]},{"hash":"298980157947859001","title":"Viral integration and retrotransposition proteins","description":"This cluster\u2019s top GO terms center on proviral latency establishment, DNA integration, retrotransposition, and DNA transposition, with additional notes on viral entry into host cells and symbiont-related host interactions, pointing to a shared function in genome integration and mobile element activity.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":9},{"id":"GO:0015074","count":9},{"id":"GO:0032197","count":9},{"id":"GO:0075732","count":9},{"id":"GO:0039651","count":9}]},{"hash":"1321851066022961857","title":"Developmental morphogenesis with cytoskeleton remodeling and apoptosis","description":"The top GO terms cluster around embryonic development and morphogenesis (neural tube closure, skeletal system development, neuron projection development) with strong ties to cell migration and actin cytoskeleton regulation, plus apoptotic signaling pathways. This suggests a theme of development linked to cytoskeletal dynamics and programmed cell death, with some background terms like heart-rate regulation appearing as secondary associations. Overall, a cohesive developmental and cytoskeletal/apoptotic program best fits the group.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0086091","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0008285","count":3}]},{"hash":"148993332764671169","title":"Neural Sensory Perception and Signaling","description":"The most represented terms point to neural sensory processes: sensory perception of pain, visual perception, and a neuropeptide signaling pathway, with additional mentions of synapse assembly regulation. This pattern suggests a cluster enriched for neuronal signaling and sensory processing functions. Other terms (temperature response, prostaglandin stimulus, diet-induced thermogenesis) reflect neuronal signaling contexts or stress responses; a few terms (heart development, magnesium homeostasis) may be secondary annotations. Overall, the cluster seems to reflect neural sensory signaling and synaptic communication.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0007218","count":4},{"id":"GO:0071502","count":4},{"id":"GO:0002024","count":4},{"id":"GO:0010961","count":4}]},{"hash":"223459802425468342","title":"Chromatin modification and transcriptional regulation","description":"The proteins in this cluster predominantly relate to histone modifications (H3K4, H3K27), nucleosome assembly, and positive regulation of transcription by RNA polymerase II, pointing to an epigenetic regulation theme. Although there are a few terms tied to extracellular matrix organization and placental morphogenesis, the core signal centers on chromatin state changes and transcriptional control, suggesting these proteins work mainly in gene expression regulation rather than ECM structure.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0030198","count":3},{"id":"GO:0044648","count":3},{"id":"GO:1901674","count":3},{"id":"GO:0098532","count":3},{"id":"GO:0006334","count":3}]},{"hash":"1772146255038987420","title":"Lignocellulose degradation and metal transport","description":"This cluster is dominated by GO terms for cellulose catabolic process and lignin catabolic process, pointing to plant biomass degradation. Additional terms indicate transport and assimilation of metal ions (copper, iron) and arsenate, suggesting a broader metabolic capacity that includes metal handling. There are also secondary metabolism (antibiotic biosynthesis) and nitrate assimilation terms, which reflect metabolic versatility but do not override the core plant-polymers\u2013metal transport theme. Overall, the strongest cohesive theme is degradation of lignocellulose with associated metal ion transport; thus the label. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0017000","count":5},{"id":"GO:0042128","count":4},{"id":"GO:0043093","count":4},{"id":"GO:0006825","count":4}]},{"hash":"1871439674431153622","title":"Innate phagocytosis and ROS regulation","description":"This cluster is dominated by GO terms tied to neutrophil-mediated antimicrobial activities (neutrophil killing, phagocytosis), regulation of reactive oxygen species, and immune signaling (IL-10, IL-15, CCL5 production). While there are a couple of housekeeping or cell-structure terms (e.g., sarcomere organization) present at lower counts, the strongest signals point to innate immune effector functions involving phagocytosis, oxidative bursts, and cytokine/chemokine production. Therefore, a concise label reflecting innate phagocytic response and ROS control seems most representative.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070945","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0046718","count":2},{"id":"GO:2000377","count":1},{"id":"GO:0032733","count":1}]},{"hash":"1284311911725490954","title":"Nuclear import and RNA transport","description":"The top GO terms cluster around import of proteins into the nucleus (NLS-bearing and ribosomal proteins, nuclear pore complex assembly) and RNA movement (mRNA transport), suggesting this group functions primarily in nuclear transport and RNA handling. Some terms about PTM regulation and signaling are present but secondary to the main theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051306","count":5},{"id":"GO:0006610","count":5},{"id":"GO:0060188","count":5},{"id":"GO:0006607","count":5},{"id":"GO:0051292","count":5}]},{"hash":"1064835943729116189","title":"Retrotransposon and proviral integration","description":"The Top Terms point to DNA integration, DNA transposition, retrotransposition, and establishment of integrated proviral latency, plus viral entry into the host nucleus. Together these terms indicate mobility of genetic elements (retrotransposons/retroviruses) and proviral genome integration as the shared theme of the cluster.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0015074","count":7},{"id":"GO:0006313","count":7},{"id":"GO:0075713","count":6},{"id":"GO:0032197","count":6},{"id":"GO:0075732","count":6}]},{"hash":"1114937610332946684","title":"Unknown","description":"The top GO terms span a broad and inconsistent set of processes\u2014from DNA integration and proviral latency to RNA processing and even pollen development\u2014without a single cohesive function linking the proteins. The lack of a clear theme or interaction among members makes it impossible to assign a specific, representative label. ","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0075713","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0008033","count":1},{"id":"GO:0090502","count":1}]},{"hash":"849930278187782968","title":"Proviral integration and latency in host","description":"The top terms are dominated by DNA integration, establishment of integrated proviral latency, viral penetration into the host nucleus, and viral release, all of which point to a retroviral-like life cycle involving genome integration and latency within the host. Additional terms about symbiont entry support a broader host\u2013microbe interaction theme, but the core signal centers on proviral integration and latency.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0039651","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0075732","count":2}]},{"hash":"224154032487863137","title":"Organogenesis Across Tissues","description":"These terms cluster around development of multiple tissues and organs (heart, skeletal, skin, vasculature, lung), with organ induction and morphogenesis as common themes, suggesting a broad organogenesis program rather than a single process. Peripheral terms (endoderm differentiation regulation, T cell proliferation) are present but not defining.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008045","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0001759","count":3}]},{"hash":"808831189911682244","title":"Retrotransposons and Proviral Integration","description":"Top terms center on DNA integration, retrotransposition, proviral latency, and viral penetration into the host nucleus, indicating a cluster enriched for mobile genetic element activity and host-virus integration processes. While a few trafficking-related terms appear, the core theme is transposable elements and proviral biology.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0075713","count":2},{"id":"GO:0032197","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0039651","count":2}]},{"hash":"1881551760722489682","title":"Unknown","description":"The top GO terms are very diverse, including apoptosis regulation (cytochrome c release and intrinsic apoptotic signaling), lipoprotein lipase activity regulation, GPI-anchor attachment, EGFR signaling, transcytosis, and neural functions (locomotory behavior, cholinergic synaptic transmission). There isn\u2019t a clear, common biological process linking all proteins, so a single cohesive label isn\u2019t supported.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090200","count":4},{"id":"GO:2001268","count":4},{"id":"GO:0051006","count":4},{"id":"GO:2001243","count":4},{"id":"GO:0007626","count":4}]},{"hash":"1913196340419984819","title":"RNA Splicing and Translation Regulation","description":"The top GO terms cluster around RNA metabolism and post-transcriptional control: multiple entries on mRNA splicing (including alternative splicing via spliceosome), mRNA export and stability, and translation control via initiation complex assembly and miRNA/ncRNA-mediated silencing. Together these terms suggest a cohesive module of proteins coordinating RNA processing and regulation of translation, with some emphasis on RNA-based silencing and stress responses.","confidence":"High","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":11},{"id":"GO:0031047","count":10},{"id":"GO:0010610","count":10},{"id":"GO:0006378","count":9},{"id":"GO:0075525","count":8}]},{"hash":"1950423633607002701","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":68,"triangles":140,"max_degree":15,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006268","count":11},{"id":"GO:0006310","count":10},{"id":"GO:0000378","count":9},{"id":"GO:0008306","count":9},{"id":"GO:1903608","count":9}]},{"hash":"153747164158144377","title":"RNA processing and translation regulation","description":"This cluster is driven by post-transcriptional RNA processing themes (splicing via spliceosome, polyadenylation regulation, mRNA stability) together with translation control elements (preinitiation complex formation and translation reinitiation) and ncRNA-mediated regulation, suggesting a cohesive module coordinating RNA maturation with translation under stress. ","confidence":"High","size":16,"edges":19,"triangles":3,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0002188","count":5},{"id":"GO:0048026","count":4},{"id":"GO:0031047","count":4}]},{"hash":"1820667899880759979","title":"Cytosolic and Mitochondrial Translation","description":"The cluster\u2019s top GO terms are dominated by translation-related processes: translation (GO:0006412) with 8 annotations, cytoplasmic translation (GO:0002181) with 1, and mitochondrial translation (GO:0032543) with 1. This strongly points to a shared function in protein synthesis across both cytosolic and mitochondrial contexts. A few additional terms (e.g., electron transport chain, peroxisome import) appear at low frequency and may reflect ancillary or secondary associations rather than a cohesive alternate function. Overall, the central theme is translation machinery across compartments.","confidence":"Medium","size":16,"edges":87,"triangles":247,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0046677","count":3},{"id":"GO:0022900","count":2},{"id":"GO:0002181","count":1},{"id":"GO:0032543","count":1}]},{"hash":"482122445405444532","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":3},{"id":"GO:0070317","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0051028","count":2}]},{"hash":"298230385301907695","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":10},{"id":"GO:0042787","count":10},{"id":"GO:0090073","count":9},{"id":"GO:0033151","count":9},{"id":"GO:0085020","count":9}]},{"hash":"14154118286451800","title":"Ubiquitin-Dependent Innate Immune Response","description":"This cluster\u2019s top terms center on innate immune defense and ubiquitin-related protein regulation (innate immune response, defense response to virus, ubiquitin-dependent ERAD pathway, and K11-linked ubiquitination). Together they suggest a theme of ubiquitin-mediated control of immune defense. Some terms are unrelated or obsolete (histone methylation, cadmium response, mitotic processes), indicating the cluster may be heterogeneous or include proteins with broader cellular roles. Overall, the most coherent interpretation is a link between ubiquitin signaling and antiviral/innate immune functions.","confidence":"Low","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0051607","count":4},{"id":"GO:2001162","count":4}]},{"hash":"540211023980818460","title":"Neural development and learning signaling","description":"The cluster\u2019s top GO terms emphasize neural differentiation and signaling, including Notch signaling, oligodendrocyte development, associative learning, and lithium response, suggesting a cohesive focus on neural development and cognitive signaling. While translation and transcription terms are present, the neural-related terms most strongly tie the proteins together into a neural development/learning theme.","confidence":"Medium","size":16,"edges":5,"triangles":1,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000463","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0046886","count":3},{"id":"GO:0006351","count":3}]},{"hash":"1649636371032150950","title":"Retrotransposons and Proviral Integration","description":"GO terms indicate DNA transposition, DNA integration, retrotransposition, proviral latency, and viral entry into the host nucleus, pointing to a cluster of mobile genetic elements and virus-host interaction processes; additional terms relate to nucleic acid metabolism but the dominant signal is transposable elements and proviral integration.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0008033","count":2}]},{"hash":"1403473359338023665","title":"Translation Regulation and Cell Cycle","description":"Dominant GO terms in this cluster are about translation and mRNA metabolism (translation, translational initiation/elongation, positive regulation of cytoplasmic translation, deadenylation-dependent decay) and on cell cycle/division (cell cycle, cell division, glial cell proliferation). This pattern suggests proteins coordinating protein synthesis with cell proliferation rather than a single pathway, hence the label. ","confidence":"Medium","size":16,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0006412","count":4},{"id":"GO:0055114","count":3}]},{"hash":"2032355857731156191","title":"Cytoskeleton-Associated Transport and RNA Processing","description":"Top GO terms point to microtubule-related transport and localization (protein localization to microtubule; anterograde synaptic vesicle transport; negative regulation of microtubule depolymerization) along with RNA processing (mRNA splicing via spliceosome). The cluster appears to blend cytoskeletal transport roles with RNA-processing signals, though the terms are mixed and some are obsolete, yielding a heterogeneous but recognizable theme.","confidence":"Low","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":2},{"id":"GO:0000185","count":1},{"id":"GO:2000653","count":1},{"id":"GO:1904246","count":1},{"id":"GO:0007014","count":1}]},{"hash":"1626634073521144518","title":"GPCR-driven neural signaling and sensory perception","description":"The cluster is dominated by GO terms linked to adenylate cyclase-activating GPCR signaling, dopaminergic synaptic transmission, visual perception/learning, and sensory pain perception, indicating proteins that participate in neural signaling and sensory processing. Additional terms touch on prostaglandin response, blood pressure regulation, and macrophage chemotaxis, suggesting broader signaling roles, with electron transport/heart development appearing as ancillary processes. Overall, the core theme appears to be neural signaling and sensory pathways with some cardiovascular and metabolic context.","confidence":"Medium","size":16,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":10},{"id":"GO:0045777","count":10},{"id":"GO:0022900","count":10},{"id":"GO:0007507","count":9},{"id":"GO:0007601","count":9}]},{"hash":"1460863976035752074","title":"Unknown","description":"The top GO terms are a mix of obsolete annotations and unrelated processes (photosynthesis, cadmium response, cytokinin signaling, heart development, centrosome maintenance). There isn\u2019t a single cohesive biological theme clearly linking these proteins, making it hard to assign a precise, representative label. ","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:1903646","count":16},{"id":"GO:2001162","count":16},{"id":"GO:0071276","count":16},{"id":"GO:0015979","count":16},{"id":"GO:1903070","count":16}]},{"hash":"2047044754435740683","title":"Unknown","description":"The top GO terms cover both core cell cycle processes (cell division, DNA replication, mitotic spindle assembly) and various immune signaling and neuronal processes (innate/adaptive immunity, defense against Gram-positive bacteria, T cell signaling, synaptic vesicle endocytosis), with no single cohesive function tying all proteins together. This makes a precise, unified label unlikely.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0006915","count":3}]},{"hash":"1902392263509720580","title":"Retroviral DNA Integration and Latency","description":"The terms point to viral-like genome integration and replication steps (DNA integration, RNA-templated DNA biosynthesis, DNA replication, recombination) and proviral latency establishment, plus host-nucleus entry\u2014hallmarks of retroviral life cycles. The inclusion of host-symbiont interaction terms suggests broader microbe\u2013host interplay but still aligns with retroviral\u2013genome integration and latency processes.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0006278","count":2},{"id":"GO:1903704","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0006310","count":2}]},{"hash":"415063260743812500","title":"Developmental Signaling and Neural-Immune Processes","description":"The top GO terms point to multiple signaling pathways (T cell receptor, Hedgehog/smoothened, Slit/Robo, prolactin) alongside developmental processes (kidney and nervous system development) and neuronal plasticity, plus clearance mechanisms. This suggests a cluster of proteins involved in coordinated signaling during development with roles in neural and immune contexts, as well as related trafficking/clearance processes, justifying a label focused on developmental signaling and neural-immune roles.","confidence":"Medium","size":16,"edges":118,"triangles":533,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050852","count":13},{"id":"GO:0007224","count":13},{"id":"GO:0035385","count":13},{"id":"GO:0001822","count":13},{"id":"GO:0007399","count":13}]},{"hash":"936987665021862628","title":"Retroviral DNA Replication and Integration","description":"The top GO terms cluster around retroviral life-cycle processes: RNA-templated DNA biosynthetic (reverse transcription), DNA replication, DNA integration, and establishment of integrated proviral latency, along with viral entry into the host nucleus and related recombination and host-interaction activities. This combination strongly suggests a retroviral genome processing and integration theme rather than a generic DNA maintenance module.","confidence":"High","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":12},{"id":"GO:0006278","count":11},{"id":"GO:1903704","count":11},{"id":"GO:0075713","count":11},{"id":"GO:0015074","count":11}]},{"hash":"889776554980367059","title":"Plant metabolism and shoot development","description":"This cluster includes GO terms tied to plant-specific metabolism and growth: strigolactone biosynthesis (a key plant hormone), secondary shoot formation, and chlorophyll and triglyceride catabolism, along with stilbene catabolic processes and nitrogen utilization. The common theme across these terms is plant metabolism with emphasis on development and hormone biosynthesis (strigolactone).","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0019260","count":3},{"id":"GO:0046272","count":3},{"id":"GO:0010223","count":3},{"id":"GO:0097755","count":3},{"id":"GO:0019433","count":3}]},{"hash":"555883663796000371","title":"Vascular remodeling and coagulation","description":"This cluster shows strong enrichment for blood coagulation, plasminogen activation, fibrinolysis, smooth muscle cell migration, and coronary artery morphogenesis, alongside a cellular response to mechanical stimulus, pointing to a cohesive vascular remodeling/hemostasis theme (neuronal terms appear less central).","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":12},{"id":"GO:0048846","count":10},{"id":"GO:0031639","count":10},{"id":"GO:0014909","count":9},{"id":"GO:0060982","count":9}]},{"hash":"413169926155325123","title":"Cardiac Muscle Structure and Development Signaling","description":"The cluster\u2019s top GO terms prominently emphasize sarcomere organization, muscle contraction, and heart development, pointing to a cardiac muscle function theme. Additional terms related to neuron projection development and sodium channel clustering align with cardiac excitability and neuromuscular interactions, suggesting a broader muscle/nerve signaling context. Some immune signaling terms appear, but they are less central to this core muscle/heart theme. Overall, the proteins appear linked to structural and signaling aspects of heart and skeletal muscle development and function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1900042","count":3},{"id":"GO:0038095","count":3},{"id":"GO:0032516","count":3},{"id":"GO:0038109","count":3},{"id":"GO:0007155","count":3}]},{"hash":"1407411001104428138","title":"Neural crest migration and axon guidance","description":"This cluster centers on neural crest\u2013driven neural development, with terms for neural crest cell migration, autonomic nervous system formation (sympathetic ganglia, autonomic nervous system development), and axon guidance, including commissural neuron guidance and paranodal junction assembly. Eye and ear development terms may reflect neural crest contributions to sensory structures; overall the common thread is neural crest\u2013derived neural development and neuronal pathfinding.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":3},{"id":"GO:1902378","count":2},{"id":"GO:0036486","count":2},{"id":"GO:0061549","count":2},{"id":"GO:0061299","count":2}]},{"hash":"1507455151784810962","title":"Axon Guidance and Neural Development","description":"This cluster is dominated by GO terms related to axon guidance and nervous system development (e.g., Roundabout signaling pathway and axon guidance), with supporting terms for neural development and related signaling. While a few terms touch on broader developmental processes (hair follicle morphogenesis, ossification), the strongest signal is neuronal wiring and neural development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035385","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0007286","count":3},{"id":"GO:0007411","count":3}]},{"hash":"2115529620222454091","title":"NF-\u03baB\u2013mediated inflammatory and antiviral signaling","description":"The dominant GO terms center on NF-\u03baB pathway regulation and signaling (positive regulation of NF-\u03baB transcription factor activity and canonical NF-\u03baB signaling), along with inflammatory and antiviral defense (inflammatory response, defense response to virus) and downstream stress pathways (JNK cascade). Additional terms touching on T-helper 1 differentiation and development suggest a broader immune/muscle development context, but the core cluster is NF-\u03baB\u2013driven inflammatory signaling.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051092","count":4},{"id":"GO:0043123","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0051607","count":3},{"id":"GO:0046330","count":3}]},{"hash":"1498936183000180392","title":"Chromosome condensation and DNA replication/repair","description":"The top GO terms indicate core processes of DNA replication, mitotic cell cycle progression, and various aspects of chromosome condensation and cohesion (e.g., sister chromatid cohesion, cohesin loading, and meiotic/chromosomal condensation), along with DNA repair via homologous recombination. While a couple terms (like cerebral cortex development) are peripheral noise, the dominant theme centers on chromatin dynamics and genome maintenance during cell division and meiosis.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0021987","count":2},{"id":"GO:0000733","count":1},{"id":"GO:0007064","count":1}]},{"hash":"954429710665809424","title":"ER Stress Proteostasis and Apoptosis","description":"The cluster\u2019s terms center on ubiquitin-proteasome\u2013mediated degradation (ERAD and proteasomal ubiquitin-dependent protein catabolic process) and apoptosis pathways triggered by ER stress (intrinsic/execution phases), indicating a shared theme of protein quality control linked to cell death; cadmium response and mRNA processing appear as ancillary connections, but the dominant signal is ER-stress\u2013driven proteostasis and apoptosis.","confidence":"High","size":16,"edges":75,"triangles":175,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030433","count":5},{"id":"GO:0032436","count":4},{"id":"GO:0071276","count":4},{"id":"GO:0043433","count":4},{"id":"GO:0097194","count":3}]},{"hash":"575329779124531627","title":"Development and immune response modulation","description":"The top GO terms are diverse, covering multicellular organism development, adaptive immune response, interferon signaling, and various forms of cell migration and adhesion. The lack of network edges and the mix of development-, immune-, and migration-related terms suggest no single cohesive function, but a broad theme around development plus immune/tissue remodeling activities. This label aims to reflect that general blend without overfitting to a specific pathway.","confidence":"Low","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0060335","count":2},{"id":"GO:0014911","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0090305","count":2}]},{"hash":"1192175842117446541","title":"Dental enamel formation and Wnt signaling","description":"The top GO terms point to enamel formation (amelogenesis) and biomineral tissue development, with the Wnt signaling pathway commonly involved in tooth development and morphogenesis. While there are also broad transcriptional regulation terms and a few other Development-related terms, the enamel biomineralization and Wnt signaling signals strongly define the cluster\u2019s likely function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0031214","count":3},{"id":"GO:0030194","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0045079","count":2}]},{"hash":"1273115872414333491","title":"Innate Immune Response","description":"The top GO terms are dominated by innate immune processes (complement activation via lectin pathway, phagocytosis recognition, basophil activation, and cell adhesion molecule production), suggesting a cluster centered on immune defense and inflammatory signaling. A few developmental terms (metanephric kidney development, cartilage condensation) appear as outliers or shared annotations, but the cohesive theme is innate immunity rather than development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":9},{"id":"GO:0006910","count":8},{"id":"GO:0072287","count":8},{"id":"GO:0010572","count":8},{"id":"GO:0090403","count":8}]},{"hash":"1799706785675826215","title":"Neuroendocrine Thermoregulation and Neuropeptide Signaling","description":"These proteins cluster around responses to temperature and thermogenesis, combined with neuropeptide signaling and autonomic regulation (vasopressin-related blood pressure, dopamine uptake in synapses, muscle relaxation). The recurring GO terms suggest a cohesive theme of neuroendocrine control of thermoregulation and cardiovascular/muscle signaling, despite lack of direct interaction evidence in the edge data.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":16},{"id":"GO:0002024","count":16},{"id":"GO:0019233","count":16},{"id":"GO:0043950","count":15},{"id":"GO:0032651","count":15}]},{"hash":"2182055286982798790","title":"Neuropeptide and Hormonal Cardiovascular Signaling","description":"This cluster centers on neuropeptide signaling, vasopressin-regulated blood pressure, renin secretion, and dopaminergic modulation, with additional links to immune signaling. The strongest recurring themes are neuropeptide/hormonal signaling and cardio\u2013vascular regulation, suggesting a cohesive neuroendocrine control of cardiovascular function.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":16},{"id":"GO:0032651","count":16},{"id":"GO:0007218","count":16},{"id":"GO:2000724","count":16},{"id":"GO:0090075","count":16}]},{"hash":"462308774865952735","title":"Vertebrate Developmental Morphogenesis","description":"This cluster centers on development and morphogenesis across multiple tissues, including neural development (synapse assembly, myelination), skeletal and inner ear morphogenesis (otolith), vascular development (endothelial migration/proliferation), and general multicellular organism development. The shared theme is vertebrate organogenesis rather than a single pathway, yielding a plausible but not singular label.","confidence":"Medium","size":16,"edges":8,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0032474","count":3}]},{"hash":"2081763673074078342","title":"Unknown","description":"The top GO terms span developmental processes (heart, tarsal gland, uterine gland development), immune signaling (interleukin-6 and interleukin-1\u03b2 production), neuropeptide signaling, and even epigenetic modification, with obsolete terms present. There is no cohesive, single function tying these proteins together, and the cluster has no edges, suggesting they do not form a unified pathway. Therefore, this cluster is best labeled Unknown.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0043547","count":2},{"id":"GO:1903699","count":2},{"id":"GO:1903709","count":2}]},{"hash":"1400306383593454043","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071038","count":2},{"id":"GO:0071042","count":2},{"id":"GO:0000467","count":2},{"id":"GO:0071035","count":2},{"id":"GO:0016973","count":2}]},{"hash":"869045381512905891","title":"Sensory Perception and Neural Signaling","description":"The set includes GO terms for taste (sour and salty), pain-related detection (temperature/mechanical), acid response, and regulation of synaptic activity, indicating a broad theme of sensory detection and neural signaling. A transcription-related term may reflect neuronal gene regulation rather than a cohesive pathway. With no edges, the grouping seems annotation-driven rather than a single module, so I assign a Medium confidence.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0050965","count":1},{"id":"GO:0035725","count":1},{"id":"GO:0050915","count":1},{"id":"GO:0050914","count":1}]},{"hash":"1455610738936122555","title":"Neural development and synaptic signaling with ECM remodeling","description":"This cluster centers on neural signaling and development (potassium transport, excitatory postsynaptic potential, cerebellar cortex development, environmental enrichment) with accompanying remodeling signals (ECM disassembly regulation, PDGF response) indicating coordinated neural maturation and tissue remodeling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006813","count":15},{"id":"GO:0018108","count":15},{"id":"GO:0090648","count":14},{"id":"GO:0021695","count":14},{"id":"GO:0097350","count":14}]},{"hash":"1854283818587075407","title":"Cytokine signaling and leukocyte migration","description":"The terms cluster around cytokine signaling (interleukin-1, interleukin-7), T cell activation, PDGF-related signaling, ephrin signaling, and cell movement (migration and adhesion/spreading), suggesting a group of proteins that coordinate immune cell signaling and migration, with some developmental signaling links. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0036120","count":14},{"id":"GO:0070498","count":14},{"id":"GO:0043552","count":14},{"id":"GO:0048013","count":14},{"id":"GO:0034446","count":14}]},{"hash":"1168017736693396750","title":"Viral DNA integration and transposition","description":"The cluster\u2019s top GO terms are dominated by DNA integration, proviral latency, and DNA transposition, with additional signals of viral entry into the host nucleus and symbiont-related host interactions, pointing to mobile genetic elements (retroviruses/transposons) and their manipulation of host cells. Some terms appear noisy or peripheral (guard cell morphogenesis, phosphate homeostasis), but the core theme is integrative processes of viral/proviral DNA and transposon mobility. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":7},{"id":"GO:0075713","count":4},{"id":"GO:0006313","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0051301","count":2}]},{"hash":"170952750643043490","title":"Unknown","description":"The top GO terms span diverse processes, including host-symbiont entry into host cells, antibiotic response, ribosome biogenesis, protein homooligomerization, sensory and neural functions, cell division, cellular fusion, cadmium response, and signaling. No single cohesive function ties these terms together for this cluster.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0007605","count":2}]},{"hash":"2178114827690269597","title":"Glutamatergic Synaptic Transmission","description":"This cluster centers on glutamatergic signaling at excitatory synapses, with GO terms for synaptic transmission, ionotropic glutamate receptor signaling, and excitatory postsynaptic potentials, plus calcium ion transport integral to postsynaptic signaling. Behavioral terms like startle response and prepulse inhibition reflect sensorimotor gating involving glutamatergic circuits, and dopamine metabolic process suggests modulatory interactions within these networks. An incidental osteoclast proliferation term is unlikely to define the core function. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035249","count":2},{"id":"GO:0035725","count":1},{"id":"GO:0035235","count":1},{"id":"GO:0001964","count":1},{"id":"GO:0002158","count":1}]},{"hash":"1719269475531918125","title":"Ubiquitin-Mediated Innate Immune Signaling","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein degradation and various ubiquitin linkages (K63, K6, polyubiquitination), paired with innate immune pathways (innate immune response, TNF signaling, JNK cascade). While circadian rhythm regulation and V(D)J recombination appear, the common theme is ubiquitin-driven modulation of immune and stress signaling. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0000209","count":7},{"id":"GO:0070534","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0042752","count":6}]},{"hash":"1376348220444894876","title":"Nociceptive-thermogenic neural signaling","description":"The top GO terms point to pain perception and temperature response, along with diet-induced thermogenesis, neuropeptide signaling via GPCRs, inflammation, and regulation of blood pressure and vasoconstriction, plus calcium signaling and mitochondrial energy processes. Together, these suggest neural circuits that integrate nociception and thermoregulation with metabolic and vascular control, rather than a single enzymatic function. Confidence: Medium","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0071502","count":9},{"id":"GO:0002024","count":9},{"id":"GO:0051209","count":8},{"id":"GO:0007218","count":7}]},{"hash":"515071202619910222","title":"Thermogenesis-linked GPCR signaling and metabolism","description":"The top terms point to a cohesive theme of metabolic regulation intertwined with cellular signaling in response to temperature stress\u2014thermogenesis and temperature stimuli, GPCR-driven signaling, Rho/GTPase and ERK pathways, and energy metabolism (electron transport chain). While a couple of terms (e.g., viral release) are less fitting, the dominant pattern centers on thermogenesis and signaling-driven metabolic control.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":8},{"id":"GO:0002024","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0010579","count":7},{"id":"GO:0035025","count":7}]},{"hash":"597836549357159398","title":"Cell adhesion and tissue remodeling","description":"This cluster is enriched for GO terms centered on cell\u2013cell and cell\u2013ECM interactions (cell adhesion), ECM turnover (proteoglycan catabolic process, fibrinolysis regulation), and cell movement and morphogenesis (fibroblast migration, endothelial tube morphogenesis, T cell chemotaxis), suggesting proteins involved in adhesion, remodeling, and coordinated cell migration during tissue remodeling and angiogenesis. An outlier term (motor learning) may be incidental. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":4},{"id":"GO:0051918","count":4},{"id":"GO:0001558","count":2},{"id":"GO:0010820","count":2},{"id":"GO:0030167","count":2}]},{"hash":"1791922902703463777","title":"Neuronal projection development and cytoskeleton regulation","description":"The dominant GO terms point to neuronal projection development and axon extension, with actin cytoskeleton regulation and cell adhesion, suggesting a neuronal morphogenesis role. Immune-related terms are present but less representative, and Hedgehog signaling may reflect broader developmental context. Thus the label reflects the main theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048675","count":3},{"id":"GO:0031175","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0051301","count":3},{"id":"GO:1900016","count":2}]},{"hash":"1802428468390138117","title":"Retroviral Integration and Latency","description":"These terms cohere around retroviral biology: DNA integration and establishment of integrated proviral latency indicate provirus insertion and maintenance in the host genome; RNA-templated DNA biosynthesis and DNA replication point to reverse transcription and genome duplication; viral penetration into host nucleus signals entry; ubiquitin-related terms and siRNA processing hints at host pathway modulation during infection; symbiont-mediated host apoptosis suggests pathogen\u2013host interaction. Overall, the cluster appears to group proteins involved in retroviral genome integration, reverse transcription, and proviral latency.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0075713","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0031397","count":3},{"id":"GO:0006278","count":2}]},{"hash":"1814564933768066464","title":"Developmental Processes and Morphogenesis","description":"The Terms include multiple developmental and morphogenetic processes across different tissues (bone morphogenesis, multicellular organism development, inner ear receptor cell development, male gonad development) and signaling pathways (positive regulation of smoothened signaling). While a few immune or reproductive terms appear (acrosome reaction, regulation of phagocytosis), the common thread is broad developmental programs and tissue morphogenesis rather than a single specific function. Thus, Developmental Processes and Morphogenesis is the best single-label summary for this cluster.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007340","count":2},{"id":"GO:0050766","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0060119","count":2},{"id":"GO:0050884","count":2}]},{"hash":"856926557231206241","title":"B Cell Activation and Germinal Center Development","description":"The dominant GO terms point to adaptive immunity and lymphocyte development, including B cell receptor signaling, germinal center formation, type 2 immune response, and dendritic cell differentiation, suggesting a focus on B cell\u2013centric activation and germinal center maturation. Additional terms reflect general cellular regulation (ubiquitin-dependent protein catabolic process, protein homooligomerization) that accompanies immune signaling. Overall, the cluster appears to reflect adaptive immune activation centered on B cells and germinal center processes.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0050853","count":5},{"id":"GO:1900477","count":5},{"id":"GO:0045497","count":5},{"id":"GO:0048741","count":5}]},{"hash":"841697285783537205","title":"Cell adhesion and tissue development","description":"This cluster is dominated by GO terms related to cell adhesion (cell-substrate and cell-cell adhesion) and extracellular matrix interactions, plus several tissue development and skeletal-associated terms (osteoblast development, biomineral tissue development, maintenance of organ identity). The presence of adhesion-related processes suggests proteins coordinating cell adhesion during tissue formation and mineralization, with a few outliers that are less representative (e.g., motor learning) but do not override the main theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061302","count":3},{"id":"GO:0045599","count":3},{"id":"GO:1904938","count":3},{"id":"GO:0048496","count":3},{"id":"GO:0010811","count":2}]},{"hash":"489969811525783278","title":"Ubiquitin-Dependent Immunity and NF-\u03baB Signaling","description":"The terms are dominated by ubiquitin-dependent protein catabolism (ERAD, autoubiquitination, ubiquitin-linked turnover including actin ubiquitination) and innate immune signaling (innate immune response, defense against virus, and positive regulation of canonical NF-\u03baB). This suggests a cluster of proteins that regulate immune responses through ubiquitin-mediated control of NF-\u03baB signaling and antiviral defenses. The vitamin D response term may reflect immunity-related modulation. Overall, the core theme is ubiquitin-driven regulation of innate immunity, especially NF-\u03baB signaling.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0030433","count":7},{"id":"GO:0051865","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0043123","count":7}]},{"hash":"1134414920158998389","title":"Ubiquitin-Driven Autophagy and Endocytosis","description":"GO terms center on ubiquitin signaling (monoubiquitination, K63-linked ubiquitination) linked to cargo trafficking, including ubiquitin-dependent endocytosis and trafficking to autophagosomes, with autophagy-related terms such as mitophagy and ribophagy, suggesting a theme of ubiquitin-regulated selective autophagy and endocytic processes.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070086","count":1},{"id":"GO:0019089","count":1},{"id":"GO:0006513","count":1},{"id":"GO:0033160","count":1},{"id":"GO:0061734","count":1}]},{"hash":"1087507818479346918","title":"Post-transcriptional RNA regulation","description":"These proteins cluster around RNA processing and post-transcriptional control: ncRNA-mediated silencing, spliceosome-mediated splicing, regulation of mRNA stability under stress, mRNA export, and translation initiation complex assembly. Together they point to a cohesive role in post-transcriptional gene expression regulation.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":10},{"id":"GO:0048026","count":10},{"id":"GO:0010610","count":8},{"id":"GO:0045292","count":8},{"id":"GO:0006378","count":8}]},{"hash":"1072137628018398629","title":"Ribosome biogenesis and RNA processing","description":"This cluster centers on the core machinery of gene expression: strong signals for cytoplasmic translation and overall translation, along with ribosome biogenesis and nuclear export of ribosomal subunits. It also includes RNA maturation processes such as 7-methylguanosine capping, cap1 methylation, and spliceosome-mediated splicing, indicating involvement in RNA processing that feeds into ribosome function. A few terms listed as obsolete do not change the overall theme. ","confidence":"Medium","size":15,"edges":14,"triangles":10,"max_degree":5,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0002181","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0006370","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0097309","count":2}]},{"hash":"1357060693014562954","title":"Cytoskeleton Remodeling and Cell Migration in Development","description":"This cluster is dominated by GO terms tied to actin and microtubule dynamics, GTPase signaling, and cell migration, with links to EMT-related Wnt signaling and developmental processes like ectoderm and organ development. The recurring themes indicate coordinated cytoskeletal remodeling driving cell movement during development, with nuclear import terms playing a supporting regulatory role.","confidence":"High","size":15,"edges":11,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0006607","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0090138","count":3},{"id":"GO:0044334","count":3}]},{"hash":"1538103156441040227","title":"Dendrite morphogenesis and synaptic signaling","description":"The cluster is dominated by neural-related processes: dendrite morphogenesis, excitatory postsynaptic potentials, regulation of synaptic vesicle endocytosis, and ephrin receptor signaling, indicating a theme of neuronal development and synaptic function. Some terms are obsolete or broad, but the core connection is neural dendrite formation and synaptic signaling.","confidence":"High","size":15,"edges":56,"triangles":97,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031532","count":5},{"id":"GO:0010738","count":4},{"id":"GO:0036035","count":4},{"id":"GO:0060079","count":4},{"id":"GO:1900242","count":4}]},{"hash":"2057837134740044624","title":"Unknown","description":"The top GO terms span viral genome integration, host apoptosis, muscle development, vesicle endocytosis, kinase regulation, sporulation membrane formation, PI signaling, GTPase activity, and the mitotic cell cycle. This wide and disjoint range, combined with no reported edges or interactions, suggests there isn\u2019t a single coherent function linking the proteins, so an Unknown label is appropriate.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0048741","count":2},{"id":"GO:1900242","count":2}]},{"hash":"1011780709986835271","title":"Photobiology and cell cycle proteins","description":"This cluster features GO terms tied to light-related processes (photoprotection, bioluminescence, chromophore linkage) alongside several cell-cycle and division terms (exit from mitosis, meiotic chromosome alignment, septin ring assembly). Additional terms touch core biosynthetic and structural functions (ribosome biogenesis, ER polarization, energy metabolism). The mixed signals suggest a cluster containing both photobiology-related factors and general cellular machinery rather than a single cohesive function, hence a dual-theme label.","confidence":"Medium","size":15,"edges":11,"triangles":6,"max_degree":4,"top_function":"generation of precursor metabolites and energy","top_go_terms":[{"id":"GO:0018298","count":3},{"id":"GO:0010117","count":3},{"id":"GO:0008218","count":3},{"id":"GO:0006091","count":3},{"id":"GO:0090529","count":2}]},{"hash":"2100526511498211656","title":"Embryonic development and ECM remodeling with angiogenesis","description":"This cluster centers on developmental processes (midbrain development, cranial skeleton morphogenesis) and extracellular matrix remodeling (collagen fibril organization, plasminogen activation, fibrinolysis) with vascular development signals (positive regulation of angiogenesis). While some immune-related terms (complement activation) appear, the dominant theme is embryonic morphogenesis coupled to ECM remodeling and blood vessel formation, justifying the label. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0030199","count":3},{"id":"GO:0001867","count":3}]},{"hash":"356611374215136984","title":"Protein catabolism and turnover","description":"The GO terms cluster around protein degradation and turnover: proteolysis, ubiquitin recycling, and catabolic processes (including insulin and bradykinin catabolic pathways). Some terms touch on mitochondrial protein processing and protein oligomerization, which relate to proteostasis and quality control. Overall, the cluster appears centered on proteostasis via protein degradation and remodeling.","confidence":"Medium","size":15,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006627","count":1},{"id":"GO:0010815","count":1},{"id":"GO:0008340","count":1},{"id":"GO:1902600","count":1},{"id":"GO:0044257","count":1}]},{"hash":"1841556701645493076","title":"Chromatin Organization and Epigenetic Silencing","description":"The terms cluster around chromatin structure and its regulation: nucleosome assembly/positioning, heterochromatin organization, histone modifications (H3K27me3, H3K4me3), transcriptional repression by RNA Pol II, and mitotic DNA replication. This points to a core function in establishing and maintaining epigenetic states within the nucleus, integrating silencing and chromosome-wide chromatin dynamics.","confidence":"High","size":15,"edges":24,"triangles":11,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":3},{"id":"GO:0030466","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0098532","count":2},{"id":"GO:0006334","count":2}]},{"hash":"1027327927848873113","title":"Retrotransposon and Proviral Latency Proteins","description":"Dominant terms are DNA transposition, DNA integration, and retrotransposition, plus proviral latency, which points to proteins involved in mobile genetic elements and retroviral integration. The other terms touch on virus-host interactions (entry/endocytosis) but do not redefine the main theme. Hence this cluster is best described as Retrotransposon and Proviral Latency Proteins.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":3},{"id":"GO:0006898","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0032197","count":2}]},{"hash":"1180796504712945952","title":"Innate Immune and Cadmium Stress Response","description":"This cluster is driven by enrichment in innate immune signaling (innate immune response, response to interferon-alpha, response to exogenous dsRNA) and metal-stress response (cellular response to cadmium ion). A mitotic cell cycle term appears, but the dominant theme is stress- and antiviral-response pathways, so the label captures the main function across the proteins. The presence of obsolete terms suggests annotation noise but does not override the core theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071276","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0035457","count":6},{"id":"GO:0071360","count":5}]},{"hash":"2294451604955534145","title":"Amino acid biosynthesis and sulfur metabolism","description":"The top GO terms cluster around amino acid biosynthesis and related sulfur metabolism: serine and cysteine/transsulfuration, homocysteine catabolism, hydrogen sulfide production, and related pathways like tryptophan biosynthesis and pyruvate metabolism. This points to a cohesive theme of amino acid biosynthesis and sulfur-containing compound metabolism, justifying a label that emphasizes those processes.","confidence":"High","size":15,"edges":102,"triangles":419,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006565","count":8},{"id":"GO:0042866","count":8},{"id":"GO:0070814","count":7},{"id":"GO:0019343","count":7},{"id":"GO:0019346","count":7}]},{"hash":"1616084637928278478","title":"Innate Immune Signaling and Pyroptosis","description":"This cluster is dominated by GO terms related to innate immunity and inflammatory cell death, especially innate immune response, pyroptotic inflammatory response, and Toll-like receptor 4 signaling. Additional terms for defense against virus and ubiquitination suggest regulation of immune signaling, while apoptotic and mitotic terms appear as secondary or incidental associations. Taken together, the proteins appear to participate in innate immune sensing and pyroptosis-driven inflammation, with ubiquitination likely supporting signaling regulation. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":15},{"id":"GO:0070269","count":13},{"id":"GO:1990001","count":13},{"id":"GO:0090307","count":13},{"id":"GO:0016567","count":13}]},{"hash":"515294033874505491","title":"Neuronal development and synaptic trafficking","description":"The cluster\u2019s terms cluster around neural development and synaptic maintenance: hippocampus development and nerve branching morphogenesis point to neuronal growth, while regulation of synaptic vesicle endocytosis and intracellular organelle distribution (mitochondria and Golgi localization) imply active trafficking and synaptic regulation. A few terms (defense response, ribosomal export, cell division) appear more generic, but the strongest signal is neuronal morphogenesis and vesicle trafficking.","confidence":"Medium","size":15,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042832","count":4},{"id":"GO:0051683","count":3},{"id":"GO:1900242","count":3},{"id":"GO:0048312","count":3},{"id":"GO:0035641","count":3}]},{"hash":"479786535051771446","title":"Retroviral integration and latency","description":"The cluster centers on retroviral life-cycle processes: reverse transcription (RNA-templated DNA biosynthesis), DNA integration, DNA recombination/ transposition, and establishment of proviral latency, plus viral entry into the host nucleus, with some acknowledgment of host-pathogen interactions.","confidence":"High","size":15,"edges":21,"triangles":11,"max_degree":6,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":6},{"id":"GO:0006278","count":5},{"id":"GO:1903704","count":5},{"id":"GO:0075713","count":5},{"id":"GO:0015074","count":5}]},{"hash":"1293788825301913266","title":"Collagen Biosynthesis and Skin Development","description":"The dominant GO terms are collagen fibril organization, collagen biosynthetic/catabolic processes, and skin development, pointing to extracellular matrix assembly/remodeling in skin. Additional terms on cell adhesion and growth factor signaling (PDGF, IGF pathways) suggest coordinated ECM dynamics and skin maturation. Overall, a coherent theme around collagen-related ECM production and skin development.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0032964","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0016525","count":3}]},{"hash":"1374538263246234525","title":"Thermogenic Neuronal Signaling","description":"Most terms cluster around neural signaling and temperature-responsive processes, including cellular response to temperature stimulus, neuropeptide signaling, and dopamine uptake in synaptic transmission, with related membrane potential regulation and muscle relaxation. The presence of diet-induced thermogenesis and vascular/muscle differentiation hints suggests a broader thermogenic/metabolic regulation axis that involves neural signaling and muscle effectors, making a cohesive theme around thermogenic neural signaling.","confidence":"Medium","size":15,"edges":10,"triangles":0,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":15},{"id":"GO:0042391","count":15},{"id":"GO:0002024","count":15},{"id":"GO:0019233","count":15},{"id":"GO:0043950","count":14}]},{"hash":"832278555463709924","title":"Neural development and stress signaling","description":"The top GO terms point to nervous system development (brain development, nervous system development) and signaling pathways (positive regulation of JNK and ERK cascades, neuron apoptosis), suggesting a neural development and stress-response theme. Immune signaling terms are present but appear as broader pathway connections rather than defining the cluster, so the central motif is neural development coupled with MAPK-mediated stress signaling.","confidence":"Medium","size":15,"edges":7,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046330","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0006977","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0043525","count":3}]},{"hash":"1205325079187944843","title":"Mitochondrial Protein Import and Processing","description":"GO terms point to a core theme of mitochondrial protein handling, including insertion into the inner membrane, import into the matrix, and associated protein processing and turnover (ubiquitin recycling; catabolic processes). Some non-mitochondrial terms may reflect annotation noise or pleiotropy, but the dominant signal ties to mitochondrial targeting and maturation of proteins.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045039","count":2},{"id":"GO:0001302","count":1},{"id":"GO:0030150","count":1},{"id":"GO:0006627","count":1},{"id":"GO:0010815","count":1}]},{"hash":"2072759948286895228","title":"Muscle contraction and calcium signaling","description":"Several top GO terms point to muscle physiology: cardiac and skeletal muscle contraction, regulation of cardiac muscle contraction via calcium release, calcium ion detection, and skeletal muscle fiber development. Together they imply a functional theme centered on how calcium signaling modulates muscle contraction, with emphasis on heart function and development. A few terms like heat response and skin development appear, but they seem peripheral to the dominant muscle/calcium regulation theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":4},{"id":"GO:0048741","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0098735","count":3},{"id":"GO:0010881","count":3}]},{"hash":"696497814643546452","title":"Developmental morphogenesis and cytoskeletal signaling","description":"The GO terms point to developmental and morphogenetic processes (skin development, multicellular growth, coronary artery morphogenesis) along with signaling pathways (regulation of ephrin receptor signaling, GTPase activity) and cytoskeletal/trafficking functions (actin filament bundle assembly, ER-to-Golgi transport). This suggests a cluster of proteins coordinating tissue formation with cytoskeletal dynamics and vesicle trafficking.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":3},{"id":"GO:0006888","count":2},{"id":"GO:0071456","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0043588","count":2}]},{"hash":"702553899279530167","title":"Neural pain and dopaminergic signaling","description":"The cluster is dominated by GO terms tied to pain perception, temperature response, dopaminergic synaptic transmission, and morphine/prostaglandin signaling, pointing to neural nociception and dopamine-mediated modulation. Related terms include diet-induced thermogenesis and macrophage chemotaxis, which can intersect with metabolic and inflammatory pathways that influence pain. The inclusion of heart development is less directly related and likely reflects pleiotropy; overall the core theme is neural pain signaling with dopaminergic signaling as a central thread.","confidence":"Medium","size":15,"edges":84,"triangles":253,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":12},{"id":"GO:0071502","count":11},{"id":"GO:0007507","count":11},{"id":"GO:0042391","count":11},{"id":"GO:0002024","count":11}]},{"hash":"833119085315840025","title":"Carbohydrate and glycoprotein biosynthesis","description":"The top GO terms center on biosynthetic processes for carbohydrates (starch, sucrose, glycogen) and glycoprotein components (GPI anchor biosynthesis, protein glycosylation), with additional lipid-related biosynthesis (phospholipids) and bacillithiol biosynthesis. This suggests a cohesive theme of building carbohydrate- and glycoprotein-containing structures, even though some terms are obsolete or broad; overall, the cluster appears biosynthesis-focused rather than degradation or signaling. ","confidence":"Medium","size":15,"edges":83,"triangles":248,"max_degree":14,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0072708","count":8},{"id":"GO:0019252","count":8},{"id":"GO:0005985","count":8},{"id":"GO:0097502","count":8},{"id":"GO:0005978","count":8}]},{"hash":"1766618398757775096","title":"NAD Salvage and Vitamin Cofactor Biosynthesis","description":"The top GO terms cluster around nicotinate nucleotide salvage and nicotinamide metabolic processes, which point to NAD metabolism, complemented by biosynthetic pathways for other cofactors such as menaquinone (vitamin K2) and cobalamin (vitamin B12). While some terms reflect broader or less direct metabolic activities (e.g., uracil catabolism, creatinine catabolism), the strongest signal is NAD-related salvage and broader vitamin cofactor biosynthesis, suggesting a module focused on cofactor production and NAD metabolism in a microbial context.","confidence":"Medium","size":15,"edges":13,"triangles":6,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0019358","count":3},{"id":"GO:0001302","count":2},{"id":"GO:1904524","count":2},{"id":"GO:0006769","count":2},{"id":"GO:0006602","count":2}]},{"hash":"345168768972048407","title":"Meiotic spindle assembly and ubiquitination","description":"The cluster\u2019s terms center on meiosis and spindle dynamics (microtubule polymerization; spindle assembly in female meiosis I; oocyte maturation) with supporting cell-cycle control (mitotic G1 DNA damage checkpoint) and regulatory ubiquitination. While there are a few outliers (cadmium response, glycoprotein catabolic processes), the dominant signal ties to meiotic spindle function and protein ubiquitination.","confidence":"High","size":15,"edges":10,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046785","count":13},{"id":"GO:0001556","count":13},{"id":"GO:0071276","count":13},{"id":"GO:0021678","count":13},{"id":"GO:0031571","count":13}]},{"hash":"1548225841237036034","title":"CoA biosynthesis and nucleotide salvage","description":"This cluster centers on coenzyme A biosynthesis alongside multiple nucleotide salvage pathways (CMP, UMP, CTP), plus broader nucleotide metabolism and phosphorylation processes. The presence of formate metabolism and tetrahydrofolate interconversion hints at connected one-carbon metabolism feeding nucleotide turnover, reinforcing a cohesive theme around cofactor and nucleotide metabolism rather than a single isolated function.","confidence":"Medium","size":15,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0015937","count":4},{"id":"GO:0016310","count":4},{"id":"GO:0046940","count":3},{"id":"GO:0046939","count":3},{"id":"GO:0044211","count":3}]},{"hash":"1955361923106435007","title":"Unknown","description":"The top terms span extracellular matrix (collagen organization/biosynthesis) and cell adhesion with immune complement activation, but also include RNA methylation and thiamine biosynthesis, plus phosphorylation. The terms do not converge on a single clear function, suggesting a heterogeneous or noisy cluster not driven by a common biology. ","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":2},{"id":"GO:0032964","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0042220","count":2}]},{"hash":"797383986626978392","title":"Unknown","description":"The top GO terms span muscle development, neural and Schwann cell processes, epithelial differentiation, fungal ascospore formation, and xenobiotic response, with little overlap pointing to a single coherent function. This heterogeneity suggests there is no unifying biological role that can be succinctly named for this cluster.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060316","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0030437","count":3},{"id":"GO:0035690","count":3}]},{"hash":"470920166447259182","title":"Embryonic development and Notch-regulated patterning","description":"Top terms indicate broad embryonic development and tissue patterning, with clear emphasis on ventral spinal cord interneuron fate commitment/differentiation and Notch signaling regulation. Other terms point to developmental morphogenesis (foregut morphogenesis, R8 cell development) and related lineage specification, suggesting the cluster represents general developmental patterning processes rather than a single molecular function.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0045746","count":6},{"id":"GO:0060579","count":4},{"id":"GO:0045463","count":4},{"id":"GO:0019800","count":4}]},{"hash":"2237841100716465562","title":"Neural development and axon guidance","description":"The top GO terms cluster around neural development and connectivity, including positive regulation of glutamatergic synaptic transmission, synapse assembly, and corticospinal neuron axon guidance/axon extension, along with Notch receptor processing. This points to roles in neural circuit formation and synaptic maturation. Additional terms for plasminogen activation and mechanical stimulus response may reflect extracellular remodeling and mechanotransduction relevant to developing neurons, while inflammatory response and vasoconstriction regulation could appear in CNS development or injury contexts. Overall, the dominant theme is neuronal development and connectivity.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045907","count":9},{"id":"GO:0051968","count":9},{"id":"GO:0031639","count":9},{"id":"GO:0071260","count":9},{"id":"GO:0051965","count":9}]},{"hash":"40142868301762225","title":"Organogenesis signaling networks","description":"The cluster shows enrichment for GO terms related to heart, nervous system, kidney, and hippocampus development, angiogenesis, and key signaling pathways (Wnt, Hedgehog via Smoothened, Roundabout, and T cell receptor signaling), indicating a shared theme of developmental signaling coordinating organogenesis across tissues.","confidence":"High","size":15,"edges":71,"triangles":135,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0050852","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0035385","count":4}]},{"hash":"288316613835744148","title":"Embryonic organ morphogenesis and heart development","description":"The top GO terms point to broad embryonic morphogenesis across tissues (foregut, ciliary body, glomerular development) with a strong emphasis on cardiac/vascular development (endocardial differentiation, cardiac muscle growth, Notch processing, lymph circulation), suggesting a cluster of genes involved in embryonic organ formation, particularly heart-related structures.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:2001027","count":9},{"id":"GO:0042492","count":8},{"id":"GO:0007440","count":8},{"id":"GO:1902263","count":8},{"id":"GO:0060956","count":8}]},{"hash":"735489472049671649","title":"Cardiovascular Development and Coagulation","description":"The cluster\u2019s top GO terms center on blood coagulation, plasminogen activation, and fibrinolysis, together with endocardial cell differentiation, cardiac muscle tissue growth, and lymph circulation, pointing to cardiovascular development and hemostasis. While some terms relate to broader embryonic morphogenesis, the strongest signals govern cardiovascular formation and coagulation processes.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051919","count":9},{"id":"GO:0031639","count":9},{"id":"GO:0007596","count":9},{"id":"GO:0042492","count":8},{"id":"GO:0007440","count":8}]},{"hash":"618169929337622885","title":"Transcriptional stress response and tissue development","description":"This cluster centers on transcription by RNA Pol II and DNA-templated transcription, complemented by stress-related responses (xenobiotic stimulus, PERK-mediated unfolded protein response) and signaling for development and tissue morphogenesis (retina development, ventricular heart morphogenesis, wound healing). The combination suggests proteins involved in transcriptional regulation under cellular stress and in developmental pathways of cardiac/retinal tissues, justifying a label that ties transcriptional control to stress and tissue development.","confidence":"Medium","size":15,"edges":101,"triangles":405,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0042493","count":5},{"id":"GO:0055010","count":4},{"id":"GO:0035470","count":4}]},{"hash":"466799567458753627","title":"Glycosylation-linked signaling and apoptosis","description":"The top GO terms point to protein O-linked glycosylation and broader glycosylation processes, suggesting a core theme around glycoprotein maturation. Supporting signals include cellular response to cAMP and negative regulation of the JNK cascade, which tie into stress signaling and apoptosis; the presence of apoptosis (and a related pathway) further reinforces a link to cell fate decisions. Peripherally, terms like cell wall organization and protein homooligomerization hint at additional functional layers but are less central to the core glycosylation-apoptosis theme. Overall, the cluster appears to center on glycosylation-related regulation of signaling and apoptosis, with some ancillary connectivity. ","confidence":"Medium","size":15,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035269","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0071320","count":2},{"id":"GO:0071555","count":2}]},{"hash":"925855409070330855","title":"Cardiac morphogenesis and signaling","description":"This cluster centers on heart development-related GO terms (atrioventricular canal development, cardiac jelly development) and combines aspects of cytoskeletal remodeling (lamellipodium assembly), signaling (ERK/MAPK cascade regulation, insulin response), and cell polarity, suggesting a thematic group of proteins involved in cardiac tissue morphogenesis and its signaling networks.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036302","count":2},{"id":"GO:0030032","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0051123","count":1}]},{"hash":"1839824860398664213","title":"Neural development and cytoskeletal signaling","description":"The top GO terms center on neural processes (myelination in the peripheral nervous system, dendritic spine development regulation) and signaling/cytoskeletal dynamics (Rho signaling, cell adhesion, PI3K-related regulation). These suggest a theme of development-linked neural and cytoskeletal modulation, with other terms like chemokine production and heart development possibly reflecting broader, shared developmental pathways. Overall, the cluster appears to connect neural development with cytoskeletal signaling rather than a single cohesive pathway, hence this label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0090197","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0097011","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0043552","count":2}]},{"hash":"1389087562129345758","title":"Ubiquitin-dependent immune signaling","description":"The top GO terms cluster around ubiquitin-mediated proteolysis and signaling (ubiquitin-dependent degradation, autoubiquitination, K63-linked ubiquitination) and immune-related pathways (TNF/NF-\u03baB signaling, innate immune response), suggesting a functional group linked by ubiquitination-driven regulation of immune signaling.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0051865","count":7},{"id":"GO:1903265","count":7},{"id":"GO:0030433","count":7},{"id":"GO:0070534","count":6}]},{"hash":"527050783584189886","title":"Neural development and axon guidance","description":"Proteins in this group show strong enrichment for neural development and axon pathfinding terms, including axon extension, fasciculation of sensory neuron axons, cerebellum development, and neural tube closure. Additional terms on multicellular development and signaling regulation (GTPase activity and Wnt pathway) support roles in neurite outgrowth and synapse formation, suggesting a cohesive theme of neural development and axon guidance. Overall, the cluster appears to revolve around neuronal development and axon guidance processes.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043087","count":3},{"id":"GO:0090090","count":3},{"id":"GO:0048675","count":2},{"id":"GO:2001028","count":2},{"id":"GO:0007275","count":2}]},{"hash":"1943570483717953996","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031573","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0090305","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0001935","count":1}]},{"hash":"720660876592338252","title":"Cardiovascular development and VEGF signaling","description":"The terms cluster around heart development, endothelial cell behavior in response to VEGF signaling, and key signaling cascades (ERK1/2, Rho) that govern vascular development and cell movement. While there are a few outlier terms related to neuronal plasticity and pain responses, the dominant pattern supports a cardiovascular development and VEGF-angiogenesis theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0043552","count":3},{"id":"GO:0061000","count":3}]},{"hash":"1570354095686457424","title":"Glutamatergic synaptic signaling","description":"Emphasizes glutamatergic synapses and excitatory neuronal signaling (ionotropic receptor signaling, EPSP, calcium/sodium transport) and sensorimotor gating (startle, prepulse inhibition) with dopamine metabolism; a couple terms appear less related (GM-CSF response, osteoclast proliferation).","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097011","count":4},{"id":"GO:0035725","count":3},{"id":"GO:0035235","count":3},{"id":"GO:0001964","count":3},{"id":"GO:0002158","count":3}]},{"hash":"76336888773809214","title":"Unknown","description":"GO terms span splicing, signaling, immune and neural development, germline and nuclear organization with no coherent single function linking the proteins; thus a meaningful label cannot be assigned.","confidence":"","size":15,"edges":19,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":1},{"id":"GO:0038095","count":1},{"id":"GO:2001199","count":1},{"id":"GO:0048142","count":1},{"id":"GO:0051081","count":1}]},{"hash":"763170696956367887","title":"Embryonic organ development","description":"This cluster links to GO terms across bone mineralization, kidney and gonad development, cranial skeleton morphogenesis, retina layer formation, eyelid development, vascular regulation, blood coagulation, pigment cell differentiation, and urine volume control, suggesting a common theme of embryonic organogenesis and tissue morphogenesis with regulatory roles across multiple systems.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030501","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0010842","count":2}]},{"hash":"753323226198783507","title":"Neuropeptide signaling and blood pressure regulation","description":"The GO terms show strong emphasis on neuropeptide signaling, regulation of vasopressin-driven blood pressure, renin secretion, dopamine uptake regulation, and muscle relaxation, pointing to a neuroendocrine control of cardiovascular and renal signaling.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":15},{"id":"GO:0032651","count":15},{"id":"GO:0007218","count":15},{"id":"GO:2000724","count":15},{"id":"GO:0090075","count":15}]},{"hash":"698146938786039452","title":"Renal glomerular and vascular development","description":"The cluster shows strong signals for kidney development (glomerular basement membrane development; metanephric distal convoluted tubule development) plus vascular context (negative/positive regulation of angiogenesis/lymphangiogenesis) and cell adhesion, pointing to coordinated renal morphogenesis with vascularization and tissue organization. Some immune-related terms appear (complement activation), which can intersect with kidney biology, but the kidney-vascular development theme dominates.","confidence":"High","size":15,"edges":94,"triangles":337,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0016525","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0032836","count":4},{"id":"GO:0007155","count":4},{"id":"GO:1901492","count":4}]},{"hash":"568455193572989972","title":"Cartilage ECM Remodeling Regulators","description":"The top GO terms cluster around extracellular matrix components and cartilage development\u2014collagen fibril organization, proteoglycan catabolic process, and chondrocyte proliferation\u2014pointing to ECM remodeling and cartilage formation as the core theme. Additional terms about regulation of growth signaling, endothelial and immune processes, and axon guidance suggest broader developmental regulatory roles, but the strongest signal remains cartilage/connective tissue development and matrix organization. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001558","count":2},{"id":"GO:0060481","count":2},{"id":"GO:2001027","count":2},{"id":"GO:0002605","count":2},{"id":"GO:0043569","count":2}]},{"hash":"891549076159251388","title":"Integrin signaling and epithelial cell migration","description":"The cluster is dominated by GO terms for integrin-mediated signaling, positive regulation of GTPase activity, and positive regulation of keratinocyte (epithelial) migration, with accompanying Wnt signaling and general developmental signals. Together these point to coordinated cell adhesion, signaling, and directed epithelial movement, rather than a single metabolic process. Thymus development and apoptosis terms provide broader developmental context but do not override the migration/adherence theme.","confidence":"Medium","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0007229","count":3},{"id":"GO:0010765","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0048538","count":3}]},{"hash":"1622705878023517446","title":"DNA Damage Response and Repair","description":"This cluster is enriched for GO terms related to DNA damage signaling, checkpoint control (intra-S and meiosis), DNA repair, and cellular responses to ionizing radiation, indicating a shared function in sensing and responding to DNA damage and coordinating repair. Some terms are less related, but the dominant theme centers on DNA damage response and repair processes.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016441","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0000289","count":1},{"id":"GO:0044829","count":1},{"id":"GO:0045347","count":1}]},{"hash":"2098219474692443567","title":"Unknown","description":"The GO terms are highly diverse, ranging from ribosomal RNA maturation to development, macrophage activation, transcription regulation, protein tetramerization, membrane hyperpolarization, and energy homeostasis. There is no single unifying function that clearly ties all 15 proteins together, so a specific, cohesive label cannot be justified. Unknown is the most appropriate designation given the lack of a common theme.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0042116","count":1},{"id":"GO:0045944","count":1},{"id":"GO:0043951","count":1}]},{"hash":"1486547601616798452","title":"Innate immune signaling and interferon production","description":"This cluster's top GO terms center on toll-like receptor signaling (TLR4 and TLR8) and positive regulation of type III interferon production, pointing to innate immune sensing and antiviral defense. The presence of cellular oxidant detoxification supports a stress-response/immune context. Obsolete terms and unrelated entries (e.g., myelination, DNA transposition) seem incidental, so the main signal is immune signaling. Therefore the label Innate immune signaling and interferon production best represents the cluster.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0090305","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0019800","count":1}]},{"hash":"487520837159284633","title":"Retroelement and Proviral Integration","description":"The cluster is dominated by GO terms for DNA integration, retrotransposition, proviral latency, and viral entry into the host nucleus, which together point to retroelements and integrated viral sequences as the shared function. Some terms about host-symbiont interactions and neural processes appear as outliers but do not define the main theme. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":9},{"id":"GO:0075713","count":7},{"id":"GO:0032197","count":7},{"id":"GO:0075732","count":7},{"id":"GO:0039651","count":7}]},{"hash":"1983019120058835628","title":"Cardiovascular GPCR and Neuropeptide Signaling","description":"These proteins appear to be involved in cardiovascualr and neurohumoral signaling, with GO terms highlighting GPCR signaling that activates adenylate cyclase, ERK cascades, Rho signaling, and neuropeptide pathways, along with heart development and blood pressure regulation. Some terms (defense response, IL-1\u03b2 production, and electron transport) are less directly tied to this theme, possibly reflecting broader signaling or metabolic roles, but the dominant pattern supports cardiovascular and neuropeptide signaling as the cluster\u2019s gist.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":11},{"id":"GO:0035025","count":11},{"id":"GO:0045777","count":11},{"id":"GO:0022900","count":11},{"id":"GO:0007507","count":10}]},{"hash":"1849879255209110921","title":"RNA processing and developmental regulation","description":"This cluster shows enrichment for spliceosome-mediated splicing and transcriptional regulation, complemented by several development-related terms (endocardial cushion EMT, endocrine system development, left-right patterning, pancreatic cell development). The common thread appears to be gene expression control during development, though the set also includes general RNA metabolism terms, making the theme broad but still coherent.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0090305","count":1},{"id":"GO:0006313","count":1},{"id":"GO:1903026","count":1},{"id":"GO:0003198","count":1}]},{"hash":"184728493352996314","title":"Nitrate Transport and Plant Hormone Signaling","description":"This cluster centers on nitrate uptake and assimilation, as well as transport of oligopeptides/dipeptides, indicating nutrient transport roles. The presence of GO terms for auxin-activated signaling and gibberellic acid homeostasis suggests coordination between nutrient uptake and plant growth hormone signaling. A plant-specific nutrient-transport/hormone theme best explains the combination of nitrate-related and hormone-related terms.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":2},{"id":"GO:0035672","count":2},{"id":"GO:0009635","count":2},{"id":"GO:0010167","count":2},{"id":"GO:0080055","count":2}]},{"hash":"1491681935978185912","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904246","count":1},{"id":"GO:1904628","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0071364","count":1},{"id":"GO:0098789","count":1}]},{"hash":"1838228171622648841","title":"Unknown","description":"The terms mix DNA-related processes (DNA integration, DNA biosynthetic process, DNA transposition, viral DNA genome replication) with unrelated topics such as thiamine metabolism, cAMP biosynthesis, and developmental processes (root development, germarium-derived cystoblast division). With no clear, cohesive function linking all members and no edges to suggest a shared pathway, there isn\u2019t a robust single-label theme to assign. ","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0042357","count":1},{"id":"GO:0006772","count":1},{"id":"GO:0048364","count":1}]},{"hash":"1849983209103679887","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010587","count":1},{"id":"GO:0030260","count":1},{"id":"GO:0019076","count":1},{"id":"GO:0039702","count":1},{"id":"GO:0015074","count":1}]},{"hash":"1356527397103354957","title":"Neural development and synaptic signaling","description":"The cluster is dominated by neural-related terms: axonogenesis, positive regulation of synapse assembly, excitatory postsynaptic potential, visual perception, long-term memory, and calcium ion transport, all pointing to neuronal development and synaptic function. While terms like heart development and angiogenesis appear, the core theme centers on neural growth and communication, with amphetamine response also aligning with neuronal activity. Overall, the set centers on neural development and synaptic signaling rather than non-neural processes.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007409","count":4},{"id":"GO:0051965","count":3},{"id":"GO:0006816","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0007507","count":3}]},{"hash":"779082190019298100","title":"Proviral DNA Integration and Latency","description":"The cluster centers on DNA integration with explicit proviral latency and host-cell entry terms, indicating viral or proviral processes (integration into the genome, latency establishment, and symbiont/host-entry steps). A few additional terms (response to xenobiotics, light, cadmium) are low-frequency and less cohesive but do not override the main viral integration theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0075713","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0090309","count":1},{"id":"GO:0042493","count":1}]},{"hash":"1747953170840055317","title":"Developmental Signaling and Cell Migration","description":"This cluster shows enrichment in terms tied to developmental signaling and morphogenesis\u2014sprouting angiogenesis and Hedgehog pathway regulation point to morphogen-driven growth, while neural development (sympathetic ganglion development, axon guidance) and substrate adhesion-dependent spreading reflect coordinated cell movement and tissue remodeling. Additional terms cover broad signaling responses (prostaglandin, estradiol) and remodeling processes (bone remodeling), suggesting a cohesive theme of developmentally guided cell behavior across multiple tissues, despite some terms being more peripheral.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002042","count":3},{"id":"GO:0045880","count":3},{"id":"GO:0061549","count":3},{"id":"GO:0071679","count":3},{"id":"GO:0007340","count":2}]},{"hash":"937064480495803239","title":"Unknown","description":"The top terms span a wide mix of processes (DNA transposition, endothelial proliferation, cell adhesion, necroptosis, autophosphorylation regulation, magnesium homeostasis, and responses to prolactin or brain-derived neurotrophic factor). The absence of interconnected functions and the lack of edges in the cluster prevent a coherent, specific label. Therefore, Unknown with None confidence.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":2},{"id":"GO:0001935","count":1},{"id":"GO:0090305","count":1},{"id":"GO:1990637","count":1},{"id":"GO:0016340","count":1}]},{"hash":"533184435744166207","title":"Viral entry and retrotransposon integration","description":"Top GO terms cluster around viral processes: entry into host cells, proviral latency, DNA integration, and retrotransposition, suggesting a module of viral genome integration and mobile element activity. A few terms about melanocyte proliferation and development appear less related and may reflect annotation noise.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":6},{"id":"GO:0075713","count":5},{"id":"GO:0015074","count":5},{"id":"GO:0032197","count":5},{"id":"GO:0075732","count":5}]},{"hash":"810036707536595061","title":"Transmembrane transporters for sugars, ions, xenobiotics","description":"The top GO terms point to diverse transmembrane transport activities, including nitrite/nitrate transport, sodium ion transport, and several sugar (galactose, arabinose) transports, plus xenobiotic transport and related metabolism. This suggests the cluster is enriched for membrane transport proteins handling uptake/export of ions and small molecules (nutrients and xenobiotics), with the neurotransmitter loading term reflecting a related vesicular transport aspect. Confident this captures the main theme of the cluster.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0035725","count":2}]},{"hash":"1663889017393197655","title":"Mitosis: Chromosome Condensation and Separation","description":"The top terms are dominated by mitosis-related processes (mitotic sister chromatid separation and mitotic chromosome condensation), which suggests the cluster centers on chromosome dynamics during cell division. The remaining terms (calcium signaling, Golgi transport, reproductive development, etc.) appear as peripheral or noisy annotations, not forming a cohesive alternative theme. Therefore the most representative label focuses on mitotic chromosome behavior, with the caveat of potential non-specific annotations. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051306","count":2},{"id":"GO:0090502","count":2},{"id":"GO:0070509","count":1},{"id":"GO:0061180","count":1},{"id":"GO:0030728","count":1}]},{"hash":"846065551700519161","title":"RNA Splicing and Transcription Regulation","description":"This cluster shows a strong representation of RNA processing and spliceosome-related activities, including spliceosomal disassembly, RNA exon ligation, and positive regulation of mRNA splicing, along with a term for transcription regulation by RNA polymerase II. While there are a few terms touching DNA replication/integration and endosome transport, the RNA processing and transcription control terms predominate, making RNA splicing and gene expression regulation the most coherent theme for this set of proteins.","confidence":"Medium","size":14,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000390","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0034498","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0000378","count":1}]},{"hash":"1722199990804752898","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":12,"triangles":0,"max_degree":4,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000184","count":6},{"id":"GO:0042273","count":6},{"id":"GO:0000472","count":6},{"id":"GO:0000466","count":6},{"id":"GO:0000463","count":6}]},{"hash":"1145069007965969259","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":4},{"id":"GO:0006369","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0048701","count":3},{"id":"GO:0006260","count":3}]},{"hash":"1046901008566025846","title":"Cardiac morphogenesis and SA node electrophysiology","description":"The top GO terms cluster around heart development and cardiac electrical function: right atrium morphogenesis, venous endothelial differentiation, and Notch signaling in heart-field cardioblast proliferation point to cardiogenesis, while regulation of SA node cell action potential highlights cardiac electrophysiology. Additional terms about cellular responses to mechanical stimulus and hypoxia fit cardiac tissue physiology, with other items like proteasome assembly and heat response representing general cellular stress rather than core function. ","confidence":"High","size":14,"edges":4,"triangles":1,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0003213","count":5},{"id":"GO:0060843","count":5},{"id":"GO:0003270","count":5},{"id":"GO:0033280","count":5},{"id":"GO:0071260","count":5}]},{"hash":"2159843962033114072","title":"Intracellular trafficking and organelle dynamics","description":"This cluster features GO terms centered on intracellular transport and organelle maintenance, including nuclear import, mRNA transport, and GTPase regulation, as well as organelle dynamics such as vacuole fusion/inheritance and mitochondrial calcium signaling. Developmental processes like axonogenesis and cardiac myofibril assembly also tie into cytoskeletal and transport roles, supporting a cohesive theme around intracellular trafficking and organelle function.","confidence":"Medium","size":14,"edges":17,"triangles":11,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0043065","count":6},{"id":"GO:0055003","count":6},{"id":"GO:0007409","count":5},{"id":"GO:0051561","count":5},{"id":"GO:0006607","count":5}]},{"hash":"956238855362118405","title":"RNA processing and splicing regulation in stress granules","description":"This cluster is dominated by RNA-centric processes: mRNA splicing regulation, exon ligation, and polyadenylation/decay pathways, along with ncRNA-mediated gene silencing and localization to cytoplasmic stress granules. The presence of rRNA processing-related terms and ribosomal subunit assembly hints at broader RNA metabolism and ribosome biogenesis links. Taken together, the proteins likely function together in post-transcriptional RNA processing and stress-related RNA turnover.","confidence":"Medium","size":14,"edges":83,"triangles":296,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":9},{"id":"GO:0031047","count":9},{"id":"GO:1903608","count":8},{"id":"GO:0000464","count":6},{"id":"GO:1901407","count":6}]},{"hash":"179556867363710847","title":"Proliferation and Translation Initiation Machinery","description":"Explanation: The strongest shared functions are cell proliferation/mitosis and translation initiation (translation reinitiation and preinitiation complex formation), indicating a core cluster of growth and protein-synthesis machinery. Additional terms point to microtubule-associated localization and trafficking, with peripheral signals from signaling/immune pathways, but the dominant theme remains proliferation coupled with translation initiation.","confidence":"Medium","size":14,"edges":67,"triangles":162,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008283","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0035372","count":2}]},{"hash":"1874210835719449625","title":"ABA-Responsive Nuclear RNA Processing","description":"The cluster centers on nuclear RNA metabolism and transcription-related processes: tRNA processing, mRNA decapping/splicing, spliceosomal complex assembly, and transcription termination/ import into the nucleus. The added stress signals\u2014response to water deprivation and response to abscisic acid\u2014indicate these RNA-level activities are linked to ABA-mediated drought response in plants, suggesting a coordinated regulation of RNA processing under stress.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":4},{"id":"GO:0000290","count":3},{"id":"GO:0008334","count":3},{"id":"GO:0009414","count":3},{"id":"GO:0051170","count":3}]},{"hash":"19762006419546228","title":"Unknown","description":"The terms span immune defense, development, transcriptional regulation, metal ion response, and TORC1 signaling, with no single shared function, so a cohesive label cannot be determined.","confidence":"","size":14,"edges":13,"triangles":2,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0071276","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0006349","count":2}]},{"hash":"222197360452263752","title":"Embryonic development transcriptional regulators","description":"The cluster is enriched for transcription-related GO terms (RNA polymerase II transcription, DNA-templated transcription) alongside diverse embryonic development processes (lung vasculature and bronchiole development, floor plate development, somitogenesis, placental development, amacrine cell differentiation) and apoptosis regulation. This pattern points to a set of proteins that act as transcriptional regulators coordinating broad embryonic development and tissue differentiation across multiple lineages, rather than a single tissue-specific function. Confidence: High","confidence":"","size":14,"edges":90,"triangles":352,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":10},{"id":"GO:0060426","count":7},{"id":"GO:0035881","count":7},{"id":"GO:0001756","count":7},{"id":"GO:0033504","count":7}]},{"hash":"428022623089550033","title":"Unknown","description":"The GO terms span diverse areas: lipid metabolism, xenobiotic/carotenoid-like degradation, and methylation/demethylation, plus both plant hormone biosynthesis (brassinosteroids, ent-kaurene oxidation) and animal pathways (prostaglandin biosynthesis, uterus development, inflammatory regulation). This mix lacks a single cohesive biological function or process that ties all proteins together, so no specific, representative label can be confidently assigned.","confidence":"","size":14,"edges":44,"triangles":48,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006641","count":8},{"id":"GO:0046232","count":7},{"id":"GO:0032259","count":7},{"id":"GO:0070989","count":7},{"id":"GO:0060065","count":7}]},{"hash":"1764729520531336508","title":"Neurodevelopment and One-Carbon Metabolism","description":"Most terms center on neural development (midbrain/forebrain morphogenesis, pituitary and neuromuscular processes, male gonad development) and are complemented by one-carbon metabolism (betaine and choline catabolism, tetrahydrofolate metabolism), suggesting a neurodevelopmental program supported by methyl/donor pathways; a virus-defense term is an outlier.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006579","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0030901","count":3},{"id":"GO:0048853","count":3}]},{"hash":"933719843648828923","title":"Kidney development and immune signaling","description":"This cluster is strongly driven by GO terms for metanephric proximal tubule development, metanephric distal tubule morphogenesis, and mesonephric duct development, pointing to kidney development. The presence of immune-related terms (complement activation lectin pathway, phagocytosis recognition, basophil activation, platelet activation) and inflammatory signaling (arachidonate secretion) suggests additional immune activity, which may reflect pleiotropy or linked processes in developing tissues. Overall, the dominant theme is kidney development with accompanying immune-related signals, hence this label. ","confidence":"Medium","size":14,"edges":13,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0090238","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0006910","count":2}]},{"hash":"1702089623206942423","title":"Neural development and synaptic function","description":"The top GO terms cluster around neuronal growth and signaling: axonogenesis, excitatory postsynaptic potential, long-term synaptic potentiation, visual perception, and Schwann cell development, all indicating neural development and synaptic activity. While a few terms (heart development, plant signaling) are less related, the dominant theme ties to neural maturation and synaptic plasticity. ","confidence":"High","size":14,"edges":88,"triangles":331,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":13},{"id":"GO:0007507","count":13},{"id":"GO:0007409","count":13},{"id":"GO:0007601","count":13},{"id":"GO:0043065","count":13}]},{"hash":"1840921948854366608","title":"Neural development and cell polarity signaling","description":"The top GO terms cluster around neural development and polarization, including cerebellar cortex formation, Bergmann glial differentiation, regulation of axon regeneration, and establishment of cell polarity. Some terms touch on cell-cycle and metabolic signaling (kinetochore localization, CDK activity, insulin signaling), which are less central but may reflect broader regulatory context. Overall, the cluster seems best described by neural development with polarity control, rather than a single non-neural function.","confidence":"Medium","size":14,"edges":19,"triangles":9,"max_degree":8,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0034501","count":7},{"id":"GO:0050852","count":7},{"id":"GO:0021697","count":7},{"id":"GO:0008285","count":7},{"id":"GO:0060020","count":7}]},{"hash":"2149185349401355715","title":"DNA Replication and Repair","description":"The cluster is dominated by GO terms tied to DNA metabolism and genome maintenance (DNA recombination, replication, topological changes, SOS response), with a few outliers; this supports labeling as DNA Replication and Repair.","confidence":"High","size":14,"edges":30,"triangles":22,"max_degree":11,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042766","count":5},{"id":"GO:0010501","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0090394","count":4},{"id":"GO:0009432","count":4}]},{"hash":"2122497169988591488","title":"Neural apoptosis and brain development with innate immunity","description":"Top terms show strong signals for neuronal and glial apoptosis (intrinsic ER-stress\u2013related, pyroptosis, neuron/glial apoptotic processes) and brain development, with additional innate immune/inflammatory signaling. While there is also a cell-division term, the apoptotic and neural development themes dominate, making this label a coherent representation of the cluster.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0090307","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0051260","count":5},{"id":"GO:1902510","count":4}]},{"hash":"2069572429146468153","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001938","count":2},{"id":"GO:0008380","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0030490","count":1},{"id":"GO:0000472","count":1}]},{"hash":"1911034580673517048","title":"ECM Remodeling in Development and Inflammation","description":"This cluster centers on proteolysis and breakdown of extracellular matrix components (collagen, basement membranes) and associated tissue remodeling (bone resorption, inflammatory processes like bradykinin catabolism). Developmental signals (lung branching, neural proliferation, thyroid hormone response) further tie these proteolytic processes to growth and tissue restructuring. The common theme is proteolysis-driven remodeling of tissue architecture during development and immune/inflammatory contexts.","confidence":"Medium","size":14,"edges":80,"triangles":259,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0010815","count":8},{"id":"GO:2000179","count":8},{"id":"GO:0097067","count":8},{"id":"GO:0030574","count":8},{"id":"GO:0045453","count":8}]},{"hash":"1508219499703987775","title":"Heart development and cardiovascular morphogenesis","description":"This cluster\u2019s top GO terms concentrate on heart formation and related cardiovascular processes, including heart development (GO:0007507), endocardial differentiation (GO:0060956), and cardiac muscle tissue growth (GO:0055017), with supporting embryonic morphogenesis terms like foregut morphogenesis and somitogenesis regulation. While a couple of terms (lipopolysaccharide response, gamma-delta T cell differentiation) appear incidental, the dominant signal points to cardiac development and vascular/cardiac tissue maturation.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0014807","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0042492","count":3}]},{"hash":"122312519670802804","title":"Retinoid metabolism and signaling","description":"This cluster is dominated by GO terms for retinol and retinal metabolism and regulation of retinoic acid receptor signaling, indicating a core focus on retinoid metabolism and signaling. Additional terms point to related lipid mediator (prostaglandin) and antioxidant (glutathione) biosynthesis, along with tissue and renal water homeostasis, suggesting broader metabolic and homeostatic roles tied to vitamin A pathways.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":13},{"id":"GO:0042574","count":12},{"id":"GO:0046370","count":11},{"id":"GO:0048385","count":10},{"id":"GO:0001894","count":10}]},{"hash":"1992517720640571554","title":"Neural development and synaptic signaling","description":"This cluster is dominated by neural-related terms: neuron development, nervous system development, cerebellar cortex development, and excitatory postsynaptic potential, plus plasticity-related response to environmental enrichment. While a few terms (chemotaxis, neutrophil clearance) are unrelated, the overall theme centers on CNS development and synaptic function.","confidence":"High","size":14,"edges":63,"triangles":137,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046827","count":11},{"id":"GO:0048666","count":8},{"id":"GO:0043433","count":8},{"id":"GO:0006935","count":8},{"id":"GO:0006351","count":8}]},{"hash":"764376651082109212","title":"Ubiquitin-Proteasome Degradation and Antiviral Defense","description":"The cluster is dominated by GO terms for ubiquitin-dependent proteolysis (ubiquitin-dependent protein catabolic process, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, protein polyubiquitination, autoubiquitination) and innate immune/defense responses to viruses, suggesting a core theme of ubiquitin-mediated protein degradation linked to antiviral signaling. Peripheral terms like cadmium response and aging appear as secondary stress-related associations. ","confidence":"Medium","size":14,"edges":2,"triangles":0,"max_degree":1,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0031146","count":7},{"id":"GO:0030433","count":6},{"id":"GO:0071276","count":6},{"id":"GO:0000209","count":6}]},{"hash":"398925143716003888","title":"Regulation of signaling and proteostasis","description":"The top GO terms point to regulation of GTPase activity and kinase/autophosphorylation processes, suggesting roles in signal transduction, while accompanying terms involve protein degradation pathways (SCF ubiquitin-dependent proteasomal turnover, ERAD), hypoxic response, and cell cycle-related processes, indicating a cluster of regulators that interface signaling with proteostasis and cellular stress responses. This supports a cohesive theme around signaling modulation and protein turnover, though the term diversity lowers precision. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0031954","count":5},{"id":"GO:0071456","count":5},{"id":"GO:0071902","count":5},{"id":"GO:0051028","count":5}]},{"hash":"1926687283879491018","title":"Mitogenic signaling and proliferation regulation","description":"Top GO terms indicate a convergence on positive regulation of cell proliferation and mitotic processes, driven by kinase activity and autophosphorylation, with supporting roles for GTPase regulation and protein interactions. While there are additional terms (mRNA transport, skin development, hypoxia response), the dominant theme is signaling pathways that promote growth and division, making this label representative of the cluster.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070208","count":5},{"id":"GO:0031954","count":4},{"id":"GO:0008284","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0071902","count":4}]},{"hash":"633946336234762509","title":"Innate immune signaling and pyroptosis","description":"This cluster is dominated by GO terms related to innate immunity and inflammatory signaling (innate immune response, TLR4 signaling, NOD2 signaling) and pyroptotic inflammatory response, with concomitant apoptosis. Ubiquitination appears prominently, suggesting regulation of immune signaling cascades. Altogether, the functions point to innate immune activation and inflammatory cell death, though a few terms like mitotic spindle assembly may be less connected and reflect annotation noise.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016567","count":11},{"id":"GO:0045087","count":11},{"id":"GO:0032088","count":10},{"id":"GO:0070431","count":10},{"id":"GO:0070269","count":10}]},{"hash":"176216223192002581","title":"Neuronal signaling and drug-response proteins","description":"This cluster centers on neural communication, with terms for excitatory and inhibitory postsynaptic potentials and sodium ion transport, pointing to neurotransmission and ion-channel activity. The inclusion of responses to nicotine, ethanol, and cocaine suggests these proteins also participate in chemical- or drug-induced modulation of neural signaling. Some terms (optic nerve morphogenesis, skeletal muscle growth, ovulation rhythm) are less core but may reflect multifunctional roles. Overall, the group seems to represent proteins involved in neuronal signaling and drug-associated responses.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060079","count":8},{"id":"GO:0071361","count":8},{"id":"GO:0042220","count":8},{"id":"GO:1901214","count":7},{"id":"GO:0021631","count":7}]},{"hash":"772486962895878483","title":"Neuroendocrine and cardiovascular signaling","description":"This cluster is dominated by GO terms related to neuropeptide signaling, vasopressin-regulated blood pressure, renin secretion, and dopamine-related synaptic signaling, plus regulation of chemokine and interleukin production. Together, these terms point to a cohesive theme of neuroendocrine control of cardiovascular function and associated signaling pathways, with immune signaling as a connected facet. Although one term is obsolete, the overall pattern supports a single functional theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":14},{"id":"GO:0032651","count":14},{"id":"GO:0007218","count":14},{"id":"GO:2000724","count":14},{"id":"GO:0090075","count":14}]},{"hash":"757349549088025143","title":"Vacuolar amino acid transporters","description":"The GO terms cluster around transport activities moving amino acids into or out of the vacuole (histidine export, serine/lysine/arginine import, proline transport), indicating a shared function in vacuolar amino acid storage and nitrogen/nutrient handling. Some terms like response to food and hepatocyte differentiation appear incidental, but the dominant pattern supports vacuolar amino acid transport.","confidence":"Medium","size":14,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032094","count":2},{"id":"GO:0070365","count":2},{"id":"GO:0007626","count":2},{"id":"GO:0006867","count":2},{"id":"GO:0089708","count":2}]},{"hash":"2163185510156336545","title":"Notch-regulated myogenesis and vasculogenesis regulators","description":"This cluster centers on GO terms for negative regulation of Notch signaling, DNA-templated transcription, and positive regulation of myoblast differentiation and vasculogenesis, pointing to transcriptional regulators that coordinate muscle and blood vessel development while modulating Notch. Obsolete hydroxylation terms appear, likely reflecting related modification processes but not defining the core function. Overall, a cohesive theme around transcriptional control of myogenesis and vasculogenesis with Notch involvement.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045746","count":7},{"id":"GO:0006351","count":6},{"id":"GO:0045663","count":5},{"id":"GO:2001214","count":5},{"id":"GO:0036138","count":5}]},{"hash":"1876190029315008905","title":"Blood Vessel Development and Smooth Muscle Regulation","description":"The cluster\u2019s top terms cluster around vascular biology: blood coagulation, endothelial chemotaxis regulation, smooth muscle cell migration and proliferation, and developmental processes tied to the vasculature. These collectively point to vascular development and remodeling with smooth muscle involvement, making this the most representative label, despite a few outlier terms related to neural development.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":9},{"id":"GO:0014909","count":8},{"id":"GO:0001501","count":8},{"id":"GO:2001027","count":8},{"id":"GO:0007596","count":8}]},{"hash":"355561730807346784","title":"Neuronal development and synaptic signaling","description":"The terms emphasize neural development and synaptic function\u2014neuronal migration to the olfactory bulb, branching morphogenesis, and regulation of synaptic vesicle exocytosis and excitatory signaling\u2014with a few generic cell-cycle or ubiquitination terms likely reflecting progenitor biology.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000300","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0007049","count":2},{"id":"GO:1902499","count":1},{"id":"GO:2000172","count":1}]},{"hash":"1955681013337898249","title":"Eye development and photoreceptor differentiation","description":"This cluster shows GO terms linked to vision and retinal development (visual perception, camera-type eye photoreceptor cell differentiation) and related signaling (Notch, VEGF) as well as neural-axonal context (paranodal junction assembly), suggesting a cohesive theme around eye/retina development and photoreceptor maturation, with some supporting neural and metabolic connections.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000680","count":2},{"id":"GO:0030913","count":2},{"id":"GO:0007601","count":2},{"id":"GO:1904352","count":2},{"id":"GO:0043128","count":2}]},{"hash":"2138247071327793243","title":"Unknown","description":"The top terms span cilium and tubulin assembly, RNA polymerase I/II/III assembly, transcription elongation regulation, protein folding, lysosome localization, and chromosome segregation, which covers microtubule/ciliary structure, nuclear transcription machinery, and general cellular processes with no single cohesive function. Given the lack of a unifying theme and no edges, a single interpretable label cannot be assigned.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060271","count":2},{"id":"GO:0007021","count":1},{"id":"GO:0032968","count":1},{"id":"GO:1990115","count":1},{"id":"GO:1990113","count":1}]},{"hash":"865223033530321767","title":"B cell signaling and germinal center formation","description":"This cluster is dominated by immune-related GO terms, notably B cell receptor signaling, germinal center formation, and dendritic cell differentiation, pointing to adaptive immune activation and lymphoid development. Some other terms appear noisy or unrelated, but the core theme centers on immune signaling.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":2},{"id":"GO:1900477","count":2},{"id":"GO:0045497","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0042092","count":2}]},{"hash":"709612843534800967","title":"LPS-induced inflammation and ECM remodeling","description":"Top GO terms show strong signals for immune response to lipopolysaccharide and inflammatory response, supplemented by proteolysis and extracellular matrix-related processes (hyaluronan biosynthesis), as well as mechanosensitive responses (response to mechanical stimulus, muscle stretch) and regulation of angiogenesis. This combination suggests a cluster of proteins involved in innate immune activation and concurrent tissue remodeling/ECM dynamics in response to inflammatory stimuli and mechanical cues.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032496","count":6},{"id":"GO:0006508","count":5},{"id":"GO:0044130","count":5},{"id":"GO:1903588","count":5},{"id":"GO:0006954","count":5}]},{"hash":"1885949146488458594","title":"Neuropeptide and Hormone Signaling in Blood Pressure Control","description":"The cluster is driven by neuropeptide signaling and hormonal pathways that regulate vascular tone and blood pressure, including vasopressin- and renin-mediated regulation, as well as dopaminergic signaling. The presence of IL-1\u03b2 and chemokine production regulation suggests concurrent immune signaling modulation, indicating a broader neuroendocrine-immune signaling theme centered on cardiovascular homeostasis.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":14},{"id":"GO:0032651","count":14},{"id":"GO:0007218","count":14},{"id":"GO:2000724","count":14},{"id":"GO:0090075","count":14}]},{"hash":"310051831267077181","title":"Calcium signaling and GPCR-driven metabolic responses","description":"The cluster\u2019s top GO terms cluster around calcium release into the cytosol and GPCR-activated signaling (adenylate cyclase), with downstream Rho signaling, and extend to metabolic and sensory contexts such as thermogenesis, phototransduction, pain perception, and blood pressure regulation. This points to a common theme of calcium- and GPCR-mediated signaling influencing metabolic and sensory outputs, rather than a single narrow pathway, supporting a label centered on calcium/GPCR signaling with metabolic contexts.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051209","count":3},{"id":"GO:0071502","count":3},{"id":"GO:0010579","count":3},{"id":"GO:0035025","count":3},{"id":"GO:0045777","count":3}]},{"hash":"1233724457174418736","title":"Cilia-assembly and hedgehog signaling cluster","description":"This cluster\u2019s terms are dominated by ciliary-related processes (cilium assembly, intraciliary transport) and hedgehog signaling (smoothened pathway), suggesting a shared theme around ciliary structure and signaling in development. The other terms are more general developmental or trafficking processes, but the strongest signal centers on cilia-associated function.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060271","count":1},{"id":"GO:0042073","count":1},{"id":"GO:0007224","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0001935","count":1}]},{"hash":"2145792230739982142","title":"Immune-vascular signaling and hematopoiesis","description":"This cluster centers on immune activation (adaptive immune response, complement activation, cellular response to fungal origin) and vascular remodeling (angiogenesis, endothelial migration) with related signaling (ERK cascade) and hematopoietic differentiation, suggesting a cohesive module linking inflammation to blood vessel development and blood cell formation. The presence of some developmental terms likely reflects shared signaling pathways rather than a primary focus of this cluster.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0043536","count":5},{"id":"GO:0002250","count":5},{"id":"GO:0070374","count":5}]},{"hash":"1258239629642177844","title":"Retroviral integration and latency","description":"Terms point to retroviral life cycle: DNA integration into host genome, establishment of proviral latency, and entry of viral material into the nucleus, together with reverse-transcription\u2013related processes. The presence of DNA replication/recombination and retrotransposition terms reinforces a genome-integrated, mobile genetic element theme. Overall, the cluster seems centered on proviral/retroelement biology.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0075713","count":4},{"id":"GO:0075732","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0046718","count":4}]},{"hash":"1749044796983176482","title":"Dendritic cell\u2013driven inflammation and inflammasome signaling","description":"The Top Terms converge on immune activation and innate/adaptive responses: positive regulation of type 2 immune response, inflammatory response, dendritic cell antigen processing and presentation, and positive regulation of NLRP3 inflammasome assembly. This points to a cluster of proteins involved in inflammatory signaling and antigen presentation mediated by dendritic cells and inflammasome pathways. A couple of terms about development (bone, kidney morphogenesis) appear as noise, but the dominant signal supports an immune/inflammation-focused function.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019800","count":2},{"id":"GO:0002830","count":2},{"id":"GO:0072287","count":2},{"id":"GO:0032088","count":2},{"id":"GO:0046827","count":2}]},{"hash":"2298677389588188096","title":"Unknown","description":"The terms span meiotic and mitotic processes, nuclear transport and mRNA trafficking, post-translational modification regulation, lipid metabolism, and apoptosis, with no clear single shared function. This diversity suggests there isn\u2019t a cohesive cluster theme, so the label Unknown is appropriate. ","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042518","count":2},{"id":"GO:0006610","count":2},{"id":"GO:0051306","count":2},{"id":"GO:0007143","count":2},{"id":"GO:0051028","count":2}]},{"hash":"1376410034319514133","title":"Inflammation-driven angiogenesis and remodeling","description":"The top GO terms point to immune/inflammatory processes (inflammatory response, response to lipopolysaccharide, regulation of T cell death) alongside angiogenesis-related activities (sprouting angiogenesis, endothelial proliferation regulation) and extracellular matrix remodeling (hyaluronan biosynthetic process, cell migration in sprouting angiogenesis). Additional terms related to mechanosensing and neural development (cellular response to mechanical stimulus, commissural neuron axon guidance) suggest broader tissue remodeling contexts. Together, these indicate a cluster centered on inflammation-associated tissue remodeling and vascular growth rather than a single, tightly defined pathway.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001241","count":2},{"id":"GO:0006924","count":2},{"id":"GO:1903588","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0071260","count":2}]},{"hash":"1760345020513312459","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000472","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0000398","count":2}]},{"hash":"406709195327884990","title":"Cellular Stress Response and Translation Regulation","description":"The GO terms point to a common theme of cells responding to various stresses (UV, ER stress, glucose starvation, hypoxia) and adjusting gene expression at multiple levels, including translation via eIF2alpha phosphorylation and transcriptional regulation under stress. While there are a couple of terms that seem less directly connected (e.g., androgen receptor signaling, neuron projection extension), the dominant signal is coordinated stress-responsive control of translation and transcription.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904803","count":1},{"id":"GO:0097201","count":1},{"id":"GO:0036492","count":1},{"id":"GO:0060765","count":1},{"id":"GO:0071232","count":1}]},{"hash":"1049397191749460767","title":"Neural and craniofacial development with stress responses","description":"The cluster is enriched in nervous system development terms (cerebellar cortex development) and craniofacial morphogenesis, with cell-cycle-related processes (DNA replication, mitotic centrosome separation) and regenerative potential, alongside diverse stress- and environment-related responses (lipopolysaccharide response, amino acid starvation, toxic substances, environmental enrichment) and apoptosis. This suggests a developmental program coordinating neural/craniofacial growth with cell-cycle control and stress sensing.","confidence":"Medium","size":13,"edges":16,"triangles":11,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":8},{"id":"GO:0006260","count":8},{"id":"GO:0007100","count":6},{"id":"GO:0031100","count":6},{"id":"GO:0071222","count":6}]},{"hash":"1616459499608301790","title":"Nuclear RNA processing and transcription regulation cluster","description":"The cluster is dominated by terms tied to nuclear gene expression control: transcription regulation (negative regulation of RNA Pol II), transcription initiation-coupled chromatin remodeling, mRNA transport, and nuclear import of RNA processing factors, suggesting a cohesive theme of nuclear RNA metabolism and transcription regulation; other terms reflect signaling and cell-cycle roles that can modulate these processes, but the core theme centers on nuclear RNA processing and transcription control.","confidence":"Medium","size":13,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0048096","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0051028","count":2},{"id":"GO:0070262","count":2}]},{"hash":"1842958358978454602","title":"Neuronal Development and Synapse Formation","description":"The dominant GO terms point to nervous system development, neuron projection morphogenesis, and synapse assembly, indicating a cluster centered on neuronal differentiation and connectivity. Additional terms like Golgi to plasma membrane transport and actin cytoskeleton organization support trafficking and structural remodeling required for neurite outgrowth and synaptogenesis; some terms related to angiogenesis or immune defense may reflect broader developmental or tissue-context roles, but the core signal is neuronal morphogenesis and synaptic assembly.","confidence":"High","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0050832","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0045944","count":4},{"id":"GO:0007416","count":3},{"id":"GO:0043001","count":3}]},{"hash":"1947977941904561857","title":"Post-transcriptional RNA processing and silencing","description":"This cluster centers on post-transcriptional regulation: splicing (spliceosome, alternative splicing), mRNA export and stability, and RNA silencing pathways (ncRNA- and miRNA-mediated). It also touches on translation initiation factor assembly, tying together RNA processing with translational control, indicating a cohesive role in post-transcriptional gene regulation.","confidence":"High","size":13,"edges":17,"triangles":3,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0010610","count":3},{"id":"GO:0075525","count":2},{"id":"GO:0035278","count":2}]},{"hash":"1787263177166630827","title":"RNA processing and translational regulation","description":"The cluster shows multiple GO terms related to pre-mRNA splicing (spliceosome-dependent and alternative), mRNA export, and mRNA stability under stress, plus translation initiation complex assembly and miRNA/regulatory ncRNA\u2013mediated gene silencing. Together these indicate coordinated control of RNA maturation, export, stability, and translation\u2014i.e., post-transcriptional gene regulation at multiple steps. A few terms about viral translation mechanisms are related to translation control, supporting the overall theme.","confidence":"High","size":13,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0048026","count":2},{"id":"GO:0075525","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0006406","count":2}]},{"hash":"155887502006383545","title":"Developmental Morphogenesis and Gene Regulation","description":"This cluster is dominated by GO terms tied to development and morphogenesis (skeletal system, brain, and multicellular organism development) alongside regulation of transcription and protein turnover (DNA-templated transcription, ubiquitin ligase activity). The convergence on signaling (GTPase activity), proliferation, and pigment development further supports a theme centered on developmental processes and their regulation. While some terms (cadmium response, pigmentation) may reflect broader contexts, the prevailing pattern points to developmental morphogenesis and gene regulation.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0048705","count":5},{"id":"GO:0006351","count":5},{"id":"GO:2001162","count":4},{"id":"GO:0071276","count":4}]},{"hash":"1000145032838565586","title":"Multi-tissue embryonic morphogenesis","description":"This cluster\u2019s GO terms center on embryonic development and morphogenesis across diverse tissues (axonal fasciculation, cranial skeleton, digits, pharynx, heart chambers) with some differentiation events (muscle and retinal cell fate). The terms are varied but share a common developmental theme, and there are no observed edges, indicating a broad, non-specific morphogenesis program rather than a single pathway.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097156","count":2},{"id":"GO:0090398","count":2},{"id":"GO:0060444","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0035909","count":1}]},{"hash":"93302666490397328","title":"Neural development and synaptic regulation","description":"This cluster shows enrichment in neural-related terms (neurotransmitter secretion, memory, regulation of synaptic plasticity) along with broad development terms (multicellular organism development, bone and kidney development), suggesting a general theme of neural development and signaling with some metabolic context.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":4},{"id":"GO:0043931","count":3},{"id":"GO:0072221","count":3},{"id":"GO:0007269","count":3},{"id":"GO:0007613","count":3}]},{"hash":"1080233465591379868","title":"Coagulation and Tissue Remodeling","description":"This cluster is driven by terms related to blood coagulation and fibrinolysis (positive regulation of fibrinolysis, plasminogen activation) and tissue remodeling, suggesting a core function in coagulation cascades and extracellular matrix remodeling. The presence of proliferation/differentiation terms may reflect context-specific tissue responses, but the dominant signal ties to coagulation and remodeling processes.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051919","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0031639","count":2},{"id":"GO:0048771","count":2},{"id":"GO:0038095","count":1}]},{"hash":"479838359621384280","title":"Innate immunity and mitotic regulation","description":"The cluster shows enrichment for defense response to virus and innate immune response, alongside mitotic cell cycle processes (mitotic cycle, APC-dependent catabolic process, mitotic transition) and ubiquitination-related terms (K11-linked ubiquitination). This pattern suggests a subset of proteins that interface antiviral immune signaling with cell cycle and protein turnover machinery, rather than a single purely immune or cell-cycle function.","confidence":"Medium","size":13,"edges":8,"triangles":0,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051607","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0070208","count":3},{"id":"GO:0043547","count":3}]},{"hash":"201801124257201887","title":"Mitotic spindle and actin dynamics","description":"The most represented terms are about mitosis (mitotic spindle assembly, mitotic cell cycle) and actin filament depolymerization, pointing to roles in cell division and cytoskeletal remodeling; a few obsolete terms are less informative.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030042","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0000278","count":2},{"id":"GO:2001162","count":1},{"id":"GO:0043049","count":1}]},{"hash":"194635833817521152","title":"Viral integration and proviral latency","description":"These proteins show strong representation of reverse-transcription and genome-integrating processes (RNA-templated DNA biosynthesis, DNA integration, recombination, replication) along with viral entry into the host nucleus and establishment of proviral latency. Additional terms about suppression of siRNA processing and symbiont\u2013host interactions support a theme of viral manipulation of host defenses and genome integration. Overall, the cluster most plausibly reflects factors involved in viral genome integration and proviral latency.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006278","count":6},{"id":"GO:1903704","count":6},{"id":"GO:0075713","count":6},{"id":"GO:0015074","count":6},{"id":"GO:0006310","count":6}]},{"hash":"680424213182934540","title":"Mitochondrial gene expression and RNA methylation","description":"The cluster\u2019s top GO terms mostly point to mitochondrial transcription regulation and initiation, plus rRNA and tRNA methylation and SSU-rRNA maturation, which together reflect mitochondrial gene expression and RNA processing. An additional term for N-terminal acetylation suggests linked co-translational modification, while a few lipid/isoprenoid biosynthesis terms (ergosterol, farnesyl diphosphate, carotene) may be incidental or reflect multifunctional proteins. Overall, the dominant theme is mitochondrial gene expression and RNA processing.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:1903108","count":1},{"id":"GO:0031167","count":1},{"id":"GO:0006479","count":1},{"id":"GO:0030488","count":1},{"id":"GO:0000462","count":1}]},{"hash":"1396057980200002692","title":"Vertebrate neural and skeletal development","description":"The top GO terms cluster around developmental processes, especially nervous system formation (neural tube closure, forebrain development) and skeletal system development, along with broad multicellular organism development. Although some stress/immune-related terms appear, the dominant theme is vertebrate developmental pathways, making this label representative of the cluster's function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0006349","count":2},{"id":"GO:0001403","count":2},{"id":"GO:0001843","count":2}]},{"hash":"121716017436611886","title":"RNA Processing and Ribosome Biogenesis","description":"The cluster centers on RNA maturation and ribosome assembly, highlighted by rRNA processing (5.8S/LSU) and RNA editing terms, suggesting a core role in ribosome biogenesis. Additional hints of mitochondrial import, vesicle trafficking, and cell-cycle-related terms imply broader cellular maintenance and division involvement, but the strongest link remains RNA processing and ribosome biogenesis.","confidence":"Medium","size":13,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006382","count":3},{"id":"GO:0030150","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0006890","count":2},{"id":"GO:0043547","count":2}]},{"hash":"2230337992171514959","title":"Mitochondria-linked stress, apoptosis, and calcium signaling","description":"The Top Terms point to mitochondrial stress and apoptosis (negative regulation of mitochondrial membrane potential, intrinsic apoptotic signaling in response to oxidative stress) along with calcium signaling (positive regulation of ATPase-coupled calcium transporter activity) and related cellular trafficking (ER to Golgi transport). Neural context terms (memory, response to amphetamine) and calcium-dependent processes (cardiac muscle contraction regulation) suggest a broader role for stress- and calcium-mediated signaling in neurons. Together, they support a label centered on mitochondria-associated stress responses and calcium signaling, with neural relevance.","confidence":"Medium","size":13,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010917","count":2},{"id":"GO:0008631","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0002037","count":2},{"id":"GO:0045944","count":2}]},{"hash":"367795413699658392","title":"Axon Guidance and Adhesion in Morphogenesis","description":"The GO terms converge on adhesion (homophilic/heterophilic cell\u2013cell adhesion, receptor clustering) and neuronal axon guidance (serotonergic and dopaminergic), linked to broader morphogenesis processes (planar polarity, palatal shelf morphogenesis, lung sprouting) and cell migration. This suggests a cohesive function where cell adhesion and guidance cues direct neural and tissue morphogenesis.","confidence":"High","size":13,"edges":33,"triangles":22,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0043113","count":6},{"id":"GO:0007156","count":6},{"id":"GO:0007157","count":6},{"id":"GO:0036515","count":6}]},{"hash":"786147592488628334","title":"Developmental transcription regulation and DNA methylation","description":"Based on the prominent GO terms, the cluster centers on DNA-templated transcription and multicellular development, with multiple entries pointing to epigenetic regulation via DNA methylation/imprinting and regulation of transcription initiation. The presence of nuclear maintenance and minor references to DNA repair and protein folding suggests core cellular processes accompanying developmental gene regulation. Together, these indicate a cohesive theme of transcriptional control during development mediated by epigenetic marks, hence this label.","confidence":"Medium","size":13,"edges":8,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0007275","count":4},{"id":"GO:0006349","count":4},{"id":"GO:0010529","count":3},{"id":"GO:0044026","count":3}]},{"hash":"65204730527288679","title":"Proteolytic Regulation of Neural Development","description":"Prominent terms point to proteolytic processes (plasminogen activation, fibrinolysis, coagulation) and key neural-development events (ventral spinal cord interneuron fate/differentiation, Notch signaling, synapse assembly). This suggests a cluster of proteins whose roles converge on proteolysis-driven regulation of neural development and synapse formation, with some indication of developmental remodeling.","confidence":"Medium","size":13,"edges":17,"triangles":6,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0031639","count":10},{"id":"GO:0007596","count":10},{"id":"GO:0051919","count":10},{"id":"GO:0060579","count":9}]},{"hash":"632396753396207061","title":"Immune Activation and Inflammation Signaling","description":"This cluster\u2019s GO terms are dominated by innate immune processes: complement activation, phagocytosis, basophil and platelet activation, cellular responses to fungal origin, and arachidonate (eicosanoid) signaling, all hallmark inflammatory signaling. A minority of terms relate to development (metanephric/duct formation and cartilage condensation), which may reflect broader roles of signaling pathways or annotation overlap. Overall, the shared theme is immune activation and inflammatory signaling.","confidence":"Medium","size":13,"edges":3,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":11},{"id":"GO:0001867","count":11},{"id":"GO:0090238","count":10},{"id":"GO:0001502","count":10},{"id":"GO:0006910","count":10}]},{"hash":"2122546072492723608","title":"Cardiovascular and skeletal development with angiogenesis","description":"The cluster is dominated by GO terms for heart development, skeletal system development, and positive regulation of angiogenesis, pointing to roles in cardiovascular and skeletal tissue morphogenesis and vascular formation. Additional terms like multicellular organism development and DNA-templated transcription support a broader developmental regulatory role, while glucose stimulus and prostaglandin signaling suggest integration with metabolic and inflammatory signaling during development. Some outliers (dsRNA response, sensory perception of pain) may reflect pleiotropy or annotation noise, but the core theme remains developmental and angiogenic processes.","confidence":"High","size":13,"edges":46,"triangles":70,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":8},{"id":"GO:0046827","count":7},{"id":"GO:0071333","count":7},{"id":"GO:0071380","count":7},{"id":"GO:0007275","count":7}]},{"hash":"1354666181576088429","title":"Developmental transcriptional regulators","description":"The terms highlight transcriptional regulation (DNA-templated transcription; negative regulation of transcription by RNA polymerase II) together with multiple developmental processes (brain and gonad development, multicellular organism development), suggesting proteins that regulate gene expression during development across tissues.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0007275","count":2},{"id":"GO:0030900","count":2}]},{"hash":"871696870511085793","title":"Diverse solute transmembrane transporters","description":"Most terms are transmembrane transport of diverse solutes (ions, sugars, nitrates, xenobiotics), indicating these proteins function as membrane transporters. The neurotransmitter loading term is a related but minor note. Overall, the cluster represents diverse solute transporters.","confidence":"High","size":13,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0098700","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0042128","count":2}]},{"hash":"276097061455227852","title":"Angiogenesis regulation and ECM remodeling","description":"The cluster\u2019s dominant GO terms center on blood vessel formation and regulation (positive/negative angiogenesis, endothelial cell migration), paired with cell-matrix adhesion and collagen fibril organization. The presence of bone trabecula formation and ERK signaling further supports a theme of vascular development intertwined with extracellular matrix remodeling and skeletal tissue dynamics, making this label representative of the proteins\u2019 likely collective function.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":4},{"id":"GO:0016525","count":4},{"id":"GO:0043536","count":3},{"id":"GO:2001027","count":3},{"id":"GO:0030199","count":3}]},{"hash":"145527436723546749","title":"Heart development and endothelial differentiation","description":"Most terms cluster around heart development and endothelium differentiation (venous endothelial differentiation, cardiac right atrium morphogenesis, Notch signaling in heart field). Some cytoskeletal and regulatory processes (actin filament assembly, spindle assembly, ubiquitination, SNARE regulation) support morphogenesis. Thus, a cardiovascular development cluster, centered on heart formation and vascular differentiation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060843","count":5},{"id":"GO:0071901","count":5},{"id":"GO:0003213","count":5},{"id":"GO:0016567","count":5},{"id":"GO:0003270","count":5}]},{"hash":"1817020295777071324","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":5},{"id":"GO:0043569","count":4},{"id":"GO:0061158","count":3},{"id":"GO:0043029","count":3},{"id":"GO:0001782","count":3}]},{"hash":"1329871629612568833","title":"Nucleotide metabolism and RNA editing","description":"This cluster centers on nucleotide/nucleoside metabolism (cytosine/deoxycytidine/uridine pathways, UMP salvage, guanine catabolism) and an RNA modification process (tRNA wobble A-to-I editing), suggesting a cohesive theme around nucleic acid metabolism and RNA processing, with a few peripheral terms like antibiotic response and multicellular development that are less central.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0019858","count":2},{"id":"GO:0006217","count":2},{"id":"GO:0046109","count":2},{"id":"GO:0009972","count":2}]},{"hash":"262690124968854146","title":"Hair Follicle and Gland Morphogenesis","description":"Dominant GO terms cluster around development and morphogenesis of epithelial structures, especially hair follicles (hair follicle morphogenesis, hair follicle cell proliferation) and submandibular salivary gland formation, with related epithelial proliferation in lung morphogenesis. ERK1/2 cascade regulation supports signaling-driven morphogenesis. Some neural-related and cytoskeletal terms are present but do not override the central theme of epithelial appendage and gland development.","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0050919","count":4},{"id":"GO:0016358","count":4},{"id":"GO:0034260","count":4},{"id":"GO:0031069","count":4}]},{"hash":"1912747850246485785","title":"Sensory organ development and neural connectivity","description":"The top GO terms cluster around development and formation of sensory structures (retina layer formation, ear development, otic placode development) and neural wiring (axon extension/guidance and regulation of synaptic vesicle endocytosis), with circadian rhythm and immune regulatory terms appearing as peripheral associations. This suggests a theme of sensory organ morphogenesis and neuronal connectivity, despite some outliers.","confidence":"Medium","size":13,"edges":20,"triangles":6,"max_degree":7,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:1900242","count":11},{"id":"GO:0010842","count":11},{"id":"GO:0048846","count":9},{"id":"GO:0042748","count":9},{"id":"GO:0003416","count":9}]},{"hash":"113003985070308334","title":"Proliferation and RNA Processing","description":"The top GO terms point to regulation of cell population proliferation and proliferation itself, complemented by strong signals for RNA processing and translation-related steps (mRNA splicing, formation of translation preinitiation complex, translation reinitiation, and mRNA stability). This combination suggests a cluster of proteins coordinating cell growth through regulation of gene expression at RNA processing and translational levels, with some additional but less central signals for retina development and ERAD. Overall, a coherent theme around proliferation linked to gene expression is the best fit.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":4},{"id":"GO:0008283","count":4},{"id":"GO:0060041","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0000398","count":4}]},{"hash":"1971499780379001414","title":"Visual and dopaminergic neural signaling","description":"The cluster centers on neural signaling related to sensory perception, especially vision (visual perception, visual learning) and dopaminergic synaptic transmission, with supporting motifs in GTPase regulation and protein phosphorylation that are common in neuronal signaling. There are inflammatory signaling terms (prostaglandin response, macrophage chemotaxis) that add some context, but the dominant theme is sensory neural communication, particularly visual and dopamine-mediated pathways. The heart development term appears less connected to the core signal.","confidence":"Medium","size":13,"edges":63,"triangles":159,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":9},{"id":"GO:0043547","count":8},{"id":"GO:0007601","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0043950","count":7}]},{"hash":"424258116543995928","title":"Unknown","description":"The top GO terms cover DNA replication and recombination alongside inflammatory/spleen-related processes and various metabolic and biosynthetic activities, with no single dominant function tying the proteins together. This heterogeneous mix makes a coherent, specific label unlikely.","confidence":"","size":13,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0006310","count":3},{"id":"GO:0006954","count":2},{"id":"GO:0048536","count":2},{"id":"GO:0072708","count":2}]},{"hash":"1965771451166417006","title":"DNA Damage Response and Apoptosis","description":"The cluster\u2019s strongest signals are DNA processing activities (DNA recombination, DNA integration, DNA catabolic process) together with apoptotic process, indicating involvement in DNA damage response and programmed cell death. Additional terms related to xenobiotic response and cAMP signaling appear secondary to this core theme, with corneocyte development being an outlier context. Overall, the data point to a DNA damage response and cell fate regulation cluster.","confidence":"Medium","size":13,"edges":17,"triangles":3,"max_degree":5,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":7},{"id":"GO:0015074","count":5},{"id":"GO:0006915","count":5},{"id":"GO:0006308","count":4},{"id":"GO:0042493","count":4}]},{"hash":"1204134057839928149","title":"Polysaccharide and lipid biosynthesis","description":"This cluster\u2019s terms converge on biosynthetic pathways for storage carbohydrates (starch, glycogen) and various lipids (glycolipids, phospholipids), plus related glycosylation and thiol biosynthesis (mycothiol/bacillithiol). The shared theme appears to be production of cellular polymers and membrane components, with some osmotic/stress-response connections reflecting how these biosynthetic routes respond to environmental cues.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0019252","count":3},{"id":"GO:0097502","count":3},{"id":"GO:0009414","count":3},{"id":"GO:0010125","count":3},{"id":"GO:0009247","count":3}]},{"hash":"1115787418668523783","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0006260","count":2},{"id":"GO:1990966","count":1},{"id":"GO:0097171","count":1},{"id":"GO:0006747","count":1}]},{"hash":"1298189760313370691","title":"Innate Immunity and Prostaglandin Biosynthesis","description":"The top GO terms point to innate immune response and prostaglandin biosynthetic processes, with a related term about inflammation regulation, suggesting the cluster centers on inflammatory signaling and prostaglandin-mediated communication (potentially in reproductive contexts given uterus development). A couple of other terms (carbazole catabolic, ent-kaurene oxidation) appear unrelated noise, so the core theme is inflammation/prostaglandin signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0046232","count":3},{"id":"GO:0032259","count":3},{"id":"GO:0006641","count":3}]},{"hash":"2277269201333910520","title":"Retrotransposon and Proviral Integration","description":"Based on the top GO terms, the proteins are strongly linked to DNA transposition, retrotransposition, DNA integration, and proviral latency, pointing to transposable elements and viral integration into genomes as the core function. A few unrelated terms about symbiont interactions appear but are much less represented. Therefore, the label captures the central theme of mobile genetic elements and proviral integration.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0032197","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0039651","count":2}]},{"hash":"1257859374065511586","title":"Tissue Development and Differentiation","description":"The top GO terms point to tissue- and organ-level development, with cartilage condensation and skin development appearing prominently, plus another term for metanephric collecting duct development. While a few terms relate to other processes (e.g., bacterial cell wall biosynthesis, amino acid metabolism), the strongest signal is developmental biology across tissues, justifying a tissue development label. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0071555","count":1},{"id":"GO:0030632","count":1},{"id":"GO:0070178","count":1}]},{"hash":"534585502990962311","title":"Carbohydrate Metabolism and Glycosylation","description":"The top GO terms include starch biosynthetic process, sucrose metabolic process, glycogen biosynthetic process, and mannosylation, which together point to carbohydrate metabolism and protein glycosylation as the main theme. Other terms like spermatid development and B cell homeostasis appear, but the strongest commonality across the terms is linked to sugar metabolism and glycosylation, making this a plausible functional cluster despite no network edges. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":3},{"id":"GO:0035234","count":2},{"id":"GO:0072708","count":2},{"id":"GO:0019252","count":2},{"id":"GO:0035094","count":2}]},{"hash":"2297851209093356301","title":"Developmental signaling and morphogenesis","description":"This cluster collects proteins linked to diverse developmental processes (nervous system development, hair follicle morphogenesis, spermatid development, salivary gland formation) and to ERK/MAPK signaling and vesicle trafficking (endocytosis, Golgi-ER transport), suggesting a shared role in developmental signaling guiding morphogenesis across tissues.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006897","count":2}]},{"hash":"455497411946632616","title":"Ubiquitin-Mediated Regulation of Development and Immunity","description":"The cluster shows a convergence on ubiquitination-related processes (ubiquitin-dependent protein catabolic process, protein polyubiquitination, autoubiquitination) together with regulatory roles in innate immunity (regulation of Toll-like receptor signaling, negative regulation of inflammatory response) and developmental processes (lung and male genitalia development). This points to a theme where ubiquitin-mediated control modulates both development and immune signaling, making the label representative of the predominant functional thread.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043066","count":2},{"id":"GO:0030539","count":2},{"id":"GO:0050728","count":2},{"id":"GO:0030324","count":2},{"id":"GO:0042787","count":1}]},{"hash":"326773430716919623","title":"Heart and sensory organ development","description":"The top GO terms cluster around heart development, embryonic cranial skeleton morphogenesis, and visual perception, with supporting themes of multicellular organism development and differentiation. Additional terms on GPCR signaling desensitization and proteolysis point to developmental signaling and tissue remodeling. Collectively, these proteins appear to function in organogenesis, particularly cardiac and sensory system development.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0007601","count":3},{"id":"GO:0018107","count":3},{"id":"GO:0002029","count":3},{"id":"GO:0031914","count":3}]},{"hash":"1091933577867750856","title":"Multisubstrate Membrane Transport","description":"The top GO terms collectively point to transmembrane transport across the plasma membrane for a variety of substrates\u2014xenobiotics, vitamins, ions, sugars, and related molecules\u2014consistent with a cluster of diverse transporter proteins.","confidence":"High","size":13,"edges":67,"triangles":180,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":13},{"id":"GO:0035461","count":13},{"id":"GO:0042908","count":12},{"id":"GO:0071805","count":12},{"id":"GO:0042891","count":12}]},{"hash":"1905002124747212467","title":"Sensory Signaling and Potassium Homeostasis","description":"The GO terms cluster around sensory functions (temperature response, pain perception, touch detection) and neuronal/cardiac membrane dynamics (potassium ion homeostasis, potassium transport, resting potential regulation, membrane repolarization). The mix of skin development and multicellular development supports a peripheral tissue/sensory context, with thermogenesis adding a thermal signaling angle. Together, these terms point to proteins involved in sensory signaling coupled with ion-channel\u2013mediated membrane potential maintenance. ","confidence":"Medium","size":13,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0030007","count":5},{"id":"GO:0007275","count":5}]},{"hash":"361795403974559397","title":"Immune signaling and keratinocyte differentiation","description":"The cluster contains strong immune-related terms (T cell receptor signaling, lipopolysaccharide response, GM-CSF stimulus) alongside epidermal biology (keratinocyte differentiation), plus growth/regulatory pathways (Wnt, Hippo) and transcription/apoptosis processes. This pattern suggests a cohesive theme around immune interactions within epidermal tissue and its growth/differentiation regulation, justifying a label centered on immune signaling and keratinocyte differentiation.","confidence":"Medium","size":13,"edges":20,"triangles":6,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046827","count":11},{"id":"GO:0097011","count":10},{"id":"GO:0060044","count":10},{"id":"GO:0050852","count":10},{"id":"GO:0071222","count":10}]},{"hash":"1250246767001100672","title":"Innate Immune Activation and Recognition","description":"The top GO terms are dominated by innate immune processes: cellular response to fungal origin, phagocytosis recognition, complement activation via the lectin pathway, and basophil activation, all indicating an innate defense/inflammatory theme. A few developmental terms (kidney and cartilage morphogenesis) appear incidental and don\u2019t override the core immune signal. Confidence: Medium","confidence":"","size":13,"edges":10,"triangles":1,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":11},{"id":"GO:0006910","count":10},{"id":"GO:0072287","count":10},{"id":"GO:0010572","count":10},{"id":"GO:0090403","count":10}]},{"hash":"2220553357801319326","title":"Unknown","description":"The Top Terms are highly diverse (cell division, dsRNA response, photosynthesis, cadmium response) and include several obsolete or low-confidence terms, with no edges or clustering structure. This suggests there is no single coherent function tying these proteins together, likely reflecting annotation noise or mixed functions. Therefore a meaningful, specific label cannot be assigned.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0071360","count":3},{"id":"GO:1903646","count":3},{"id":"GO:0051348","count":3},{"id":"GO:1902391","count":3}]},{"hash":"1623499216226455799","title":"Musculoskeletal and neural development","description":"The top GO terms point to development of muscle, bone, and nervous tissues\u2014skeletal muscle fiber development, bone morphogenesis, regulation of axon diameter, and myelination\u2014suggesting a shared theme of tissue and organ development across musculoskeletal and nervous systems. Additional terms about apoptotic cell clearance (phosphatidylserine exposure, engulfment) accompany remodeling processes, while glycosylation and carbohydrate metabolism terms are present but less informative for a cohesive theme. Because there are no observed edges connecting the proteins, this label represents a broad developmental context rather than a specific pathway. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":2},{"id":"GO:0006487","count":1},{"id":"GO:0005975","count":1},{"id":"GO:0043652","count":1},{"id":"GO:0042552","count":1}]},{"hash":"2937674434152231","title":"Embryonic kidney and vascular morphogenesis","description":"The terms cluster around developmental processes, notably metanephric (kidney) development and vascular/heart morphogenesis (dorsal aorta morphogenesis, endocardial cushion migration) with components of angiogenesis regulation and cell-matrix adhesion, suggesting a cohesive theme of embryonic organ development and vasculature remodeling. A single term about synapse assembly appears ancillary and does not define the cluster\u2019s main focus.","confidence":"Medium","size":13,"edges":64,"triangles":160,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0072221","count":3},{"id":"GO:0003273","count":3},{"id":"GO:0035912","count":3},{"id":"GO:0072233","count":3}]},{"hash":"1116986748029644547","title":"Neuropeptide GPCR Signaling in Thermoregulation","description":"This cluster centers on GPCR-mediated signaling and neuropeptide pathways, with emphasis on temperature-related responses (thermogenesis, cellular response to temperature) and related physiological processes such as pain perception, blood pressure regulation, and metabolic signaling. The inclusion of signaling (adenylate cyclase-activating GPCR pathway) and energy metabolism terms (electron transport chain) suggests a cohesive theme around neuroendocrine/neural control of temperature and metabolism.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0010579","count":6},{"id":"GO:0035025","count":6}]},{"hash":"1848155626515349470","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010587","count":2},{"id":"GO:0030260","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0039702","count":2},{"id":"GO:0015074","count":2}]},{"hash":"364547299245424170","title":"Retroviral Integration and Transposon Activity","description":"The top GO terms cluster around DNA integration, proviral latency, viral entry into the host nucleus, and various transposition processes (DNA transposition, retrotransposition), pointing to activity of retroelements and proviral life cycles. A few terms about host-pathogen interaction and ubiquitination support this theme, reinforcing a unifying function related to mobile genetic elements and viral integration.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0075713","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0046718","count":3}]},{"hash":"1235157224968837580","title":"Peptide processing and signaling regulation","description":"The terms center on processing of signaling-related peptides (islet amyloid polypeptide; nerve growth factor) and on regulation of signaling pathways (negative regulation of TGF-\u03b21 production; miRNA-mediated gene silencing). Additional items touch receptor/endocytic processes and developmental signaling, suggesting a broad theme around maturation and control of signaling molecules and their pathways rather than a single enzyme or receptor. This justifies a label that highlights peptide processing and regulation of signaling.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032911","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0034231","count":1},{"id":"GO:0032805","count":1},{"id":"GO:0016540","count":1}]},{"hash":"1570299044485276060","title":"Ubiquitin-dependent proteolysis and signaling","description":"The cluster is dominated by GO terms related to ubiquitination and ubiquitin-dependent protein degradation (e.g., ubiquitin-dependent protein catabolic process, K6- and K63-linked ubiquitination, protein autoubiquitination) and histone catabolic processes, with accompanying signaling roles in TNF, JNK, and stress-induced apoptotic pathways, indicating a cohesive theme of protein turnover and ubiquitin-mediated signaling.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0085020","count":8},{"id":"GO:1903265","count":8},{"id":"GO:0036205","count":8},{"id":"GO:0051865","count":8}]},{"hash":"279052986457965276","title":"Unknown","description":"The top GO terms are highly diverse (response to zinc ion; pH and bicarbonate/CO2 transport; estrogen response; GABAergic synaptic regulation; bitter taste detection; osteoclast differentiation; epithelial morphogenesis), with no single, dominant function linking the cluster. Therefore there isn\u2019t a clear, representative label beyond Unknown.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010043","count":3},{"id":"GO:0045672","count":2},{"id":"GO:0001580","count":2},{"id":"GO:0032849","count":2},{"id":"GO:0009268","count":2}]},{"hash":"536049996911253090","title":"Transposable elements and proviral integration","description":"This cluster centers on DNA integration, transposition, and proviral latency, including DNA transposition and retrotransposition, suggesting mobile elements such as DNA transposons and endogenous retroviruses; a few terms also reflect host\u2013pathogen interactions.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":9},{"id":"GO:0075713","count":6},{"id":"GO:0046718","count":5},{"id":"GO:0006313","count":4},{"id":"GO:0075732","count":3}]},{"hash":"1731957757253852551","title":"RNA Processing and Mitotic Regulation","description":"Dominant terms relate to RNA metabolism (mRNA export, tRNA processing, transcription elongation) and cell-cycle events (mitotic chromatids, centriole elongation), indicating a cohesive theme of RNA processing linked to mitosis; the presence of some developmental terms likely reflects protein pleiotropy and noise.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051306","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0008033","count":2},{"id":"GO:0042176","count":2},{"id":"GO:0048820","count":2}]},{"hash":"1878044577568671569","title":"Retroelement activity and proviral integration","description":"Top GO terms indicate DNA transposition, retrotransposition, DNA integration, proviral latency, and viral entry into the host nucleus, pointing to a cohesive theme of mobile genetic elements and virus-like integration processes. Some adjacent terms on host interaction appear but are less central to the main theme.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":10},{"id":"GO:0075713","count":8},{"id":"GO:0032197","count":8},{"id":"GO:0075732","count":8},{"id":"GO:0039651","count":8}]},{"hash":"1872738003866303959","title":"Neural development and axon guidance","description":"The top GO terms are strongly neural-focused (midbrain development; retinal ganglion cell axon guidance; trigeminal ganglion development), suggesting the proteins in this cluster are enriched for neurodevelopmental functions, especially neural patterning and axon guidance. While there are also developmental terms in other tissues (cartilage, thyroid), and some broader processes (apoptosis, transcription regulation), the neural development signals are the most prominent. The lack of network edges implies annotation-based grouping rather than direct physical interactions.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":3},{"id":"GO:0031290","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0061551","count":3},{"id":"GO:0051216","count":3}]},{"hash":"1098648428629526850","title":"Retrotransposon and proviral activity","description":"The GO terms center on DNA integration, retrotransposition, proviral latency, and viral entry into the host nucleus, suggesting the proteins are connected to transposable elements or provirus-like functions. Development-related terms may be incidental annotations. Overall, the cluster appears driven by retroelement-related activities.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0021510","count":2},{"id":"GO:0045316","count":2},{"id":"GO:0007469","count":2},{"id":"GO:0006355","count":2}]},{"hash":"2249362301115317456","title":"Nuclear RNA Splicing and Surveillance","description":"Most terms point to nuclear RNA processing: spliceosome-mediated splicing, exon ligation, poly(A)+ mRNA export, and mRNA decay pathways tied to polyadenylation. Additional items involve RNA silencing by regulatory ncRNAs and tRNA surveillance, plus stress granule localization, underscoring RNA quality control and storage during stress. A mitochondrial ribosomal subunit assembly term is less central but may reflect broader RNA metabolism connections. Overall, the cluster centers on RNA maturation, export, and surveillance.","confidence":"High","size":12,"edges":56,"triangles":165,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":9},{"id":"GO:0031047","count":9},{"id":"GO:0016973","count":6},{"id":"GO:1901407","count":6},{"id":"GO:0000378","count":5}]},{"hash":"1621104461833767475","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":47,"triangles":110,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":10},{"id":"GO:0031047","count":10},{"id":"GO:0000398","count":6},{"id":"GO:0071031","count":6},{"id":"GO:1903608","count":6}]},{"hash":"863826933568917077","title":"Embryonic development and RNA processing","description":"The top GO terms show a cohesive theme around embryonic development (neural tube closure, forebrain development, skeletal/cranial morphogenesis) while also highlighting fundamental RNA processing and ribosome biogenesis (mRNA splicing, ribosome biogenesis) that support development. Some terms related to stress or immune response appear as outliers, but the developmental core dominates, suggesting a cluster of proteins involved in developmental programs with essential gene expression machinery.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0001843","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0048701","count":2}]},{"hash":"882030022922232345","title":"Ribosome Biogenesis and Translation","description":"This cluster is driven by GO terms for translation, ribosome biogenesis (both small and large subunits), and rRNA maturation, indicating a cohesive role in assembling and operating the protein synthesis machinery (with translation reinitiation also present).","confidence":"High","size":12,"edges":62,"triangles":186,"max_degree":11,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0042254","count":4},{"id":"GO:0042273","count":3},{"id":"GO:0000463","count":2},{"id":"GO:0042274","count":2}]},{"hash":"156376821947952081","title":"Genome maintenance and cell cycle regulation","description":"This cluster centers on genome maintenance and cell cycle control, with enrichment for DNA replication, DNA recombination, translesion DNA synthesis, and centriole elongation regulation. Additional signals for transcription elongation regulation and autophagosome maturation suggest coupling to transcriptional control and cellular stress responses, with NAD+ biosynthesis providing metabolic support. Overall, it appears to represent a genome maintenance/stress-response module.","confidence":"Medium","size":12,"edges":61,"triangles":176,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0051260","count":4},{"id":"GO:0006310","count":4},{"id":"GO:1903724","count":3},{"id":"GO:0009435","count":3}]},{"hash":"574485415702630962","title":"Integrin signaling and cell adhesion regulation","description":"The proteins are enriched for integrin-mediated signaling, regulation of cell adhesion via integrins, and related processes like establishment of cell polarity and TGF-beta\u2013responsive signaling, pointing to a cohesive theme of cell\u2013matrix adhesion and signaling coordination. While other terms hint at broader development and growth contexts, the integrin adhesion/ signaling terms are the strongest unifying feature.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008285","count":3},{"id":"GO:0007172","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0033628","count":2},{"id":"GO:2000114","count":2}]},{"hash":"566731823710587024","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":3},{"id":"GO:0043044","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0015074","count":2}]},{"hash":"2268898856464648432","title":"RNA Processing and Ribosome Biogenesis","description":"This cluster centers on RNA metabolism and ribosome-related processes, with GO terms for mRNA splicing via the spliceosome, ncRNA-mediated gene silencing, maturation of rRNA and ribosomal large subunit biogenesis, and translation initiation/reinitiation. Transcription-coupled nucleotide-excision repair also ties to RNA processing in transcription contexts. Although there are no detected edges, the shared functions suggest a cohesive theme around RNA processing and ribosome assembly/translation.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0000466","count":3},{"id":"GO:0000463","count":3}]},{"hash":"674569155258098989","title":"DNA Damage Response and RNA Surveillance","description":"The cluster is dominated by terms related to genome maintenance: DNA replication (primer synthesis, unwinding), DNA topology changes, and the SOS response, complemented by nonsense-mediated decay, an RNA quality-control pathway. Although some terms are plant-specific or unrelated, the core theme appears to be DNA damage response and RNA surveillance, indicating a coherent functional cluster.","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0000184","count":3},{"id":"GO:0009432","count":3},{"id":"GO:0006265","count":3},{"id":"GO:0006269","count":3},{"id":"GO:0006268","count":3}]},{"hash":"264016588847623565","title":"Small-molecule metabolism and metal ion transport","description":"The top GO terms cluster around catabolic and metabolic processes for small molecules (ethanol, glycerol, retinol, stilbene), suggesting a metabolism-focused function; the presence of copper and cadmium ion transport terms adds a metal ion transport/homeostasis dimension, forming a module of metabolites processing with ion transport, while a few peripheral cytoskeletal/ATP-response terms are less central.","confidence":"Medium","size":12,"edges":49,"triangles":116,"max_degree":11,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006069","count":4},{"id":"GO:0042572","count":4},{"id":"GO:0006068","count":4},{"id":"GO:0071318","count":3},{"id":"GO:0046272","count":3}]},{"hash":"1027870030217433344","title":"Prostaglandin and lipid metabolism","description":"Based on the top GO terms, the cluster is enriched for prostaglandin biosynthetic process and triglyceride metabolic process, indicating a linkage to lipid metabolism and lipid-derived signaling. The presence of terms related to inflammatory response regulation and stress response further supports a role in modulating inflammation via lipid mediators. Some terms appear unrelated or context-specific (e.g., plant-specific diterpenoid oxidation), suggesting annotation noise or multifunctionality, but the lipid/prostaglandin theme is the dominant signal. Confidence: Medium","confidence":"","size":12,"edges":33,"triangles":51,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":8},{"id":"GO:0035902","count":6},{"id":"GO:0046232","count":5},{"id":"GO:0032259","count":5},{"id":"GO:0006641","count":5}]},{"hash":"1016159618043721992","title":"Retroelement Mobility and Proviral Integration","description":"The cluster is dominated by GO terms of DNA integration, retrotransposition, DNA transposition, and proviral latency, indicating activity of transposable elements and integrated viral sequences. Additional terms about symbiont entry and apoptosis hint at host\u2013symbiont interactions, but the core signal centers on mobility/integration of genetic elements. A few unrelated terms (rRNA maturation, cell wall organization, antibiotic response) may represent noise or peripheral annotations. Overall, a mobile element/proviral integration theme fits best.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0075713","count":3},{"id":"GO:0032197","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0039651","count":3}]},{"hash":"2244530938438079208","title":"Nuclear transport and mitosis","description":"This cluster is dominated by GO terms for importing and exporting macromolecules to/from the nucleus (mRNA export, NLS-bearing protein import, ribosomal protein import) and for cell division processes (mitotic metaphase chromosome alignment, cell division). Together, these suggest a coherent theme: proteins involved in nuclear trafficking that are active during mitosis. A few terms related to xenobiotic response or lipid biosynthesis are present but secondary to the central nuclear transport/mitotic theme.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":5},{"id":"GO:0007080","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0042493","count":3},{"id":"GO:0006656","count":3}]},{"hash":"106005351233318876","title":"Neurovascular development and axon guidance","description":"The GO terms cluster around nervous system development (forebrain development, axon extension/guidance) and vascular formation (coronary artery morphogenesis, endothelial cell migration), with regulation of cell-matrix/substrate adhesion and extracellular matrix components (hyaluronan biosynthesis) and signaling pathways (ERK cascade, Hedgehog/Smoothened). This points to a coordinated neurovascular development program rather than isolated functions, encompassing neural growth, vessel formation, and associated adhesion/signaling. ","confidence":"Medium","size":12,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010811","count":3},{"id":"GO:0060982","count":3},{"id":"GO:0048842","count":3},{"id":"GO:1902043","count":2},{"id":"GO:0030900","count":2}]},{"hash":"1571815008329255993","title":"Developmental and cellular processes","description":"Top terms cluster around organism and neural development (brain development, corticospinal tract morphogenesis, multicellular organism development, uterus development) with some cellular regulation (protein localization to microtubule; regulation of AV node action potential) and immune-related terms (NLRP3 inflammasome). The mix suggests a broad developmental/regulatory theme rather than a single pathway, though the combination is somewhat heterogeneous due to outliers like viral process and apoptosis; overall, developmental and cellular regulation is the best-fitting label.","confidence":"Medium","size":12,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0021957","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0060065","count":1}]},{"hash":"1083356426548795598","title":"Steroid and Retinoid Hormone Metabolism","description":"This cluster is dominated by GO terms for biosynthesis and metabolism of steroid hormones (testosterone, androgen, estrogen) and retinoids (retinal, retinol), with an additional lipid metabolism term (3-keto-sphinganine). Together these point to a cohesive theme of steroid and retinoid hormone/lipid metabolism, with a few outliers (lung development, antibiotic response) that are less central. ","confidence":"High","size":12,"edges":33,"triangles":26,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0061370","count":7},{"id":"GO:0042574","count":7},{"id":"GO:0042572","count":7},{"id":"GO:0008209","count":7}]},{"hash":"684160021801978176","title":"Cytokinesis and microtubule dynamics","description":"The top GO terms cluster around mitotic and microtubule-related activities: microtubule nucleation, spindle pole body duplication, mitotic/chromosome segregation-related cytokinesis, and general cell division, along with protein polymerization. These point to a core function in cytoskeletal organization that drives cytokinesis and division. Some terms (neuron differentiation, interleukin-4 response) are less central, likely reflecting broader roles of these proteins, but do not shift the main theme. ","confidence":"High","size":12,"edges":49,"triangles":116,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030182","count":7},{"id":"GO:0007020","count":7},{"id":"GO:0071353","count":7},{"id":"GO:1903087","count":7},{"id":"GO:0090529","count":6}]},{"hash":"2179469501500962589","title":"DNA Replication and Repair","description":"Top GO terms are DNA repair, DNA replication, and DNA-templated transcription, pointing to a core cluster of nuclear DNA metabolism functions. The additional terms cover neural development, neuronal signaling, and tissue remodeling, which may reflect context-specific roles of these proteins, but the dominant theme across the cluster is DNA maintenance and expression control.","confidence":"High","size":12,"edges":44,"triangles":79,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006281","count":12},{"id":"GO:0006260","count":12},{"id":"GO:0006351","count":12},{"id":"GO:0090648","count":11},{"id":"GO:0021695","count":11}]},{"hash":"1802598384551669404","title":"Enamelogenesis and biomineralization","description":"This cluster is anchored by GO terms related to enamel formation and mineralized tissue development (amelogenesis, biomineral tissue development), suggesting a core theme around enamel formation and related biomineralization processes. The presence of additional terms like transcription regulation and immune/coagulation pathways likely reflects pleiotropic roles of the proteins or broader annotation context, but the enamelogenesis signal is the strongest. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030901","count":6},{"id":"GO:0031214","count":5},{"id":"GO:0030194","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0001867","count":5}]},{"hash":"2116080159387802896","title":"Embryonic development and cellular stress responses","description":"The top GO terms show developmental processes (neural tube closure, forebrain development, skeletal system development, multicellular organism development) alongside stress-related and transcriptional activities (cellular response to cadmium, ER stress\u2013induced apoptotic signaling, DNA-templated transcription). This pattern suggests a cluster of proteins involved in coordinating development with stress responses and gene regulation. While the terms are broad, the recurring theme ties developmental programs to cellular stress and transcriptional control.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071276","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0006349","count":7},{"id":"GO:0001403","count":7},{"id":"GO:0001843","count":7}]},{"hash":"261961735774760156","title":"Airway epithelial adhesion and morphogenesis","description":"This cluster centers on GO terms for cell adhesion, integrin signaling, apical constriction, and lobar bronchus epithelium development, indicating a shared role in adhesion-mediated morphogenesis of airway epithelium. Other terms related to cell cycle, immune regulation, and fibrinolysis are present but not strongly cohesive with the core epithelial theme, so the label reflects the dominant function with a Medium confidence.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0051918","count":3},{"id":"GO:0001558","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0007049","count":2}]},{"hash":"519155750367090207","title":"Autophagy-Linked Ubiquitin-ERAD Vesicle Trafficking","description":"This cluster centers on autophagy-related processes (macroautophagy, mitochondrial autophagy, piecemeal autophagy of the nucleus) and vesicle transport along microtubules, with supportive roles for ubiquitin-dependent ERAD and protein sumoylation, suggesting a cohesive theme of cellular quality control and cargo trafficking during stress; a minor link to innate immune signaling is present but not dominant.","confidence":"Medium","size":12,"edges":27,"triangles":23,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0034126","count":3},{"id":"GO:0016925","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0072383","count":2},{"id":"GO:0006777","count":2}]},{"hash":"1726222160385045626","title":"Cell Cycle and Mitosis Machinery","description":"The top terms cluster around mitosis and cell cycle processes (cell cycle, cell division, spindle assembly) and chromatid cohesion regulation, suggesting a core focus on mitotic progression and chromosome management. Ribosome biogenesis and post-translational modifications (ubiquitination, PARylation) appear as related or supportive processes, indicating coordination of protein turnover and chromatin regulation during division. Overall, the cluster likely represents proteins involved in mitosis and cell cycle control, with ancillary roles in ribosome biogenesis and protein modification.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000747","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0051225","count":3}]},{"hash":"639711526616010843","title":"Neuronal potassium channels and excitability","description":"The top GO terms cluster around neuronal signaling and membrane excitability\u2014neuronal action potentials, membrane hyperpolarization, potassium ion transport, and the role of multimeric protein assemblies in channel function. While a couple terms (skin development, diet-induced thermogenesis) are less tightly connected, the dominant theme is ion-channel\u2013mediated neural activity.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":6},{"id":"GO:0060081","count":6},{"id":"GO:0071502","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0019233","count":5}]},{"hash":"304292538939270716","title":"Unknown","description":"The top GO terms are a mixed bag including photosynthesis and cytokinin signaling (plant-related) alongside cell cycle, protein folding, ubiquitin-related processes, and unrelated terms like atrial septum development, with several obsolete annotations. This lack of a coherent, shared function across the cluster makes it infeasible to assign a specific label.","confidence":"","size":12,"edges":19,"triangles":10,"max_degree":9,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:1903646","count":7},{"id":"GO:2001162","count":7},{"id":"GO:0071276","count":7},{"id":"GO:0015979","count":7},{"id":"GO:1903070","count":7}]},{"hash":"2269420741478926567","title":"Neural development and apoptosis signaling","description":"The top terms concentrate on brain development, dendrite morphogenesis, and neuron/glial apoptotic processes, with related links to ER-stress\u2013induced apoptotic signaling and general development. This points to a cluster functionally tied to neural development and associated apoptosis/stress responses rather than a single cohesive pathway, justifying the label.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0007568","count":3},{"id":"GO:1902510","count":2}]},{"hash":"2091949383262419916","title":"Ubiquitin-Dependent Proteostasis and NF-kappaB signaling","description":"The top terms cluster around ubiquitin-mediated degradation (ERAD, ubiquitin-dependent protein catabolic process, autoubiquitination) and aggresome assembly, with canonical NF-kappaB signaling components also present. A few terms like vitamin D response, triglyceride metabolism, and uterus development are less connected and likely incidental. Overall, the dominant theme is ubiquitin-dependent proteostasis linked to NF-kappaB signaling.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0006641","count":3},{"id":"GO:0060065","count":3},{"id":"GO:0070842","count":2}]},{"hash":"1633340681145061513","title":"Cell migration and adhesion signaling","description":"The top GO terms cluster around movement and attachment processes: integrin activation, regulation of filopodium assembly, and cell migration, all tied to cytoskeletal remodeling and adhesion signaling (including thrombin-activated GPCR pathways). There are also related terms like adult locomotory behavior and sensory perception of sound, which can reflect neuromuscular functions in some organisms, but the core theme across the set is movement, adhesion, and signaling that governs cellular motility. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008344","count":2},{"id":"GO:0033622","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0051489","count":2}]},{"hash":"552928495926460543","title":"Lipoprotein remodeling and cholesterol transport","description":"Proteins group around lipid metabolism: triglyceride and phospholipid catabolism, various lipoprotein particle remodeling (HDL, LDL, VLDL), intestinal cholesterol absorption, lipid digestion, and reverse cholesterol transport\u2014together indicating a module focused on lipid processing and cholesterol transport; the relatively cohesive GO term set supports a specific lipid handling theme despite a single defense term.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":7},{"id":"GO:0034375","count":4},{"id":"GO:0070328","count":4},{"id":"GO:0009395","count":4},{"id":"GO:0034374","count":4}]},{"hash":"630176492254972670","title":"Steroid Hormone and Lipid Biosynthesis","description":"The cluster centers on multiple biosynthetic processes for steroids and lipids, including estrogen and androgen (testosterone) biosynthesis, and sphingolipid/retinol metabolism, suggesting a cohesive module in steroid hormone and lipid metabolism. Some terms like lung development or antibiotic response appear as minor outliers, but the dominant theme is lipid-related biosynthesis and steroid hormone production.","confidence":"Medium","size":12,"edges":30,"triangles":34,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042572","count":11},{"id":"GO:0055114","count":11},{"id":"GO:0006703","count":10},{"id":"GO:0006666","count":10},{"id":"GO:0046677","count":10}]},{"hash":"784403550200724270","title":"Regulated cell proliferation and differentiation","description":"This cluster centers on GO terms about proliferation and differentiation across multiple lineages (myoblasts, mammary epithelial cells, trophoblast giant cells) and includes regulatory signaling and apoptosis-related terms (phosphorylation, mitochondrial cytochrome c release, oxidative stress\u2013mediated cell death). Taken together, it suggests a theme of controlled cell fate decisions and developmental growth rather than a single specific pathway, hence a broad label of regulated proliferation and differentiation.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0033137","count":2},{"id":"GO:0033601","count":2},{"id":"GO:0051450","count":2},{"id":"GO:0045445","count":2},{"id":"GO:0016476","count":2}]},{"hash":"1701882673596299173","title":"Unknown","description":"The terms include viral DNA integration and proviral latency alongside symbiont entry into host cells, but also a mix of carbohydrate metabolism and biosynthesis processes (starch, sucrose, glycogen), GPI anchor biosynthesis, and bacillithiol biosynthesis, which don\u2019t point to a single coherent function. This heterogeneous mix makes it hard to assign a precise, representative label.","confidence":"","size":12,"edges":10,"triangles":3,"max_degree":5,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0046718","count":4},{"id":"GO:0072708","count":3},{"id":"GO:0019252","count":3}]},{"hash":"167599744206665217","title":"Carbohydrate Biosynthesis and Glycosylation","description":"These proteins show enrichment for multiple carbohydrate-related biosynthetic processes (starch, glycogen, sucrose) and glycan assembly (GPI anchor biosynthesis, protein glycosylation). The inclusion of phospholipid biosynthesis aligns with lipid-linked glycan formation and membrane anchoring. An outlier term (bacillithiol biosynthesis) is noted but does not override the overall glycan- and carbohydrate-focused theme.","confidence":"Medium","size":12,"edges":29,"triangles":27,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0072708","count":6},{"id":"GO:0019252","count":6},{"id":"GO:0005985","count":6},{"id":"GO:0097502","count":6},{"id":"GO:0005978","count":6}]},{"hash":"885519130059907878","title":"Mitochondrial dynamics and apoptosis signaling","description":"The cluster shows strong enrichment for mitochondrial processes, including release of cytochrome c, mitochondrial fusion and fragmentation in apoptosis, and apoptotic signaling, which point to a shared role in mitochondrial dynamics and intrinsic cell death pathways. Some RNA processing terms are present but likely incidental.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0001300","count":4},{"id":"GO:0006370","count":3},{"id":"GO:0036265","count":3},{"id":"GO:0070584","count":3},{"id":"GO:0090200","count":3}]},{"hash":"1523020555768728021","title":"Tissue morphogenesis and differentiation","description":"This cluster includes GO terms across multiple tissues (hair follicle, dopaminergic neurons, smooth muscle, aorta, otic placode, vestibular cells, salivary gland) and processes like differentiation and morphogenesis, with additional but related terms on cell survival and cytoskeletal regulation. The common theme is broad developmental and morphogenetic activity across diverse tissues, rather than a single pathway, justifying a multi-tissue morphogenesis label.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031069","count":1},{"id":"GO:0071542","count":1},{"id":"GO:0051145","count":1},{"id":"GO:0035909","count":1},{"id":"GO:2001240","count":1}]},{"hash":"1936269597507855605","title":"Developmental signaling and cytoskeleton dynamics","description":"The GO terms point to signaling pathway regulation (ERK/MAPK, Wnt, B cell receptor) across diverse developmental contexts (nervous system, heart, spermatids) and to cytoskeletal remodeling and mechanotransduction (podosome assembly, response to mechanical stimulus), suggesting a theme of signaling coordinating development with cytoskeletal dynamics.","confidence":"Medium","size":12,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0071803","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1838730276043951399","title":"Ubiquitin-Dependent Proteolysis","description":"The GO terms are dominated by ubiquitin-related processes (ubiquitin-dependent proteolysis, K6-linked ubiquitination, ERAD) and associated signaling (I\u2011\u03baB phosphorylation, TNF signaling), suggesting a cohesive theme of ubiquitin-mediated protein turnover and quality control with links to immune signaling. An outlier term (V(D)J recombination) may reflect related immune regulation but does not outweigh the central ubiquitin/core degradation theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0033151","count":5},{"id":"GO:2000620","count":5},{"id":"GO:1903762","count":5},{"id":"GO:1903265","count":5}]},{"hash":"482718460909008418","title":"GTPase-Mediated Cell Migration Signaling","description":"The top GO terms cluster around small GTPase\u2013mediated signaling, regulation of GTPase activity, and processes involved in cell migration and cytoskeleton dynamics (cell extension, substrate-dependent migration, and regulation of JNK cascade). Though a few terms reflect broader developmental or structural roles (neuron development, spindle orientation, barrier formation), the dominant theme ties to GTPase-regulated signaling that governs cell movement and organization.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006930","count":2},{"id":"GO:0043087","count":2},{"id":"GO:0000132","count":2},{"id":"GO:0090557","count":2},{"id":"GO:0032120","count":2}]},{"hash":"51448748213866774","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043044","count":2},{"id":"GO:0000378","count":1},{"id":"GO:0008306","count":1},{"id":"GO:1902775","count":1},{"id":"GO:0071042","count":1}]},{"hash":"2164129751415610555","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010587","count":1},{"id":"GO:0030260","count":1},{"id":"GO:0019076","count":1},{"id":"GO:0039702","count":1},{"id":"GO:0015074","count":1}]},{"hash":"1591937405608491437","title":"Viral entry, genome integration, and proviral latency","description":"The top terms cluster around viral genome handling: DNA replication, DNA transposition, and especially establishment of integrated proviral latency and DNA integration, pointing to virus-host genome integration and proviral maintenance. Additional terms about symbiont entry into host cells and viral penetration into the host nucleus reinforce a virus\u2013host interaction theme centered on entry and genome integration. Some unrelated terms may reflect broader gene functions in the dataset, but the dominant signal is viral integration/latency pathways.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0006313","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0046718","count":4}]},{"hash":"1373125253108939643","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":2},{"id":"GO:0006370","count":1},{"id":"GO:1904744","count":1},{"id":"GO:0019062","count":1},{"id":"GO:0002181","count":1}]},{"hash":"752034906607060400","title":"Neural and Skeletal Development","description":"The cluster\u2019s top GO terms cluster around development of the nervous system and skeletal tissues (forebrain development, ossification, sensory neuron axon fasciculation, cell-matrix adhesion), with additional hints of vascular differentiation. This suggests proteins participate in broad tissue development across neural, skeletal, and related organ contexts, hence the label Neural and Skeletal Development.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0043931","count":5},{"id":"GO:0097155","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0030900","count":4}]},{"hash":"338756048472349562","title":"DNA transposons and retroelements","description":"The top GO terms point to movement and integration of genetic elements: DNA transposition, DNA integration, and retrotransposition, as well as establishment of integrated proviral latency. This suggests a cluster enriched for transposable elements and retroviral-like activities, with additional RNA processing and host interaction terms that can accompany such elements. Overall, a transposable element/retroelement theme best fits the data.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0075713","count":1},{"id":"GO:0015074","count":1}]},{"hash":"450253998360195492","title":"Innate Antiviral Defense","description":"The cluster is most strongly defined by GO terms related to antiviral and innate immunity (defense response to virus and innate immune response, each shown for multiple proteins). While other terms (transcription regulation, histone acetylation, etc.) are present, they are minor and likely incidental annotations; the antiviral/innate signaling appears to be the cohesive theme. Confidence: High","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":2},{"id":"GO:0006936","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0006357","count":1},{"id":"GO:0043966","count":1}]},{"hash":"1622046060757231783","title":"Neural crest migration and axon guidance","description":"This cluster centers on neural crest\u2013derived cell migration (ventral trunk neural crest migration; neural crest migration in sympathetic NS development) and axon pathfinding (semaphorin-plexin signaling, sympathetic neuron projection guidance, branchiomotor neuron axon guidance). Related terms include trigeminal nerve organization and olfactory bulb development, reinforcing a theme of peripheral nervous system development and neuron wiring. Some endothelial morphogenesis and sensory perception terms may reflect broader developmental context, but the core signal is neural crest migration with axon guidance.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036486","count":4},{"id":"GO:1902287","count":4},{"id":"GO:0097491","count":4},{"id":"GO:0097490","count":4},{"id":"GO:0021785","count":4}]},{"hash":"1881757649206413768","title":"RNA Processing and Gene Expression Regulation","description":"Driven by enrichment in mRNA splicing (spliceosome), transcription regulation by RNA Pol II, RNA silencing, and rRNA/tRNA processing, the proteins appear to function together in RNA metabolism and gene expression control, with minor links to ribosome biogenesis.","confidence":"High","size":11,"edges":40,"triangles":67,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":5},{"id":"GO:0045944","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0000398","count":4},{"id":"GO:1902775","count":3}]},{"hash":"505089505366964341","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":5,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071042","count":6},{"id":"GO:0071038","count":6},{"id":"GO:0000467","count":6},{"id":"GO:0045944","count":6},{"id":"GO:0071035","count":6}]},{"hash":"2290072189684696209","title":"RNA Processing and Ribosome Maturation","description":"This cluster is dominated by GO terms for mRNA and rRNA processing, tRNA methylation, and maturation of LSU rRNA, indicating a core RNA metabolism program; a few viral/host interaction terms appear but are peripheral.","confidence":"High","size":11,"edges":6,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":2},{"id":"GO:0006364","count":2},{"id":"GO:0002128","count":1},{"id":"GO:0006370","count":1},{"id":"GO:0039520","count":1}]},{"hash":"1363018231404080525","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":41,"triangles":77,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045944","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0000378","count":3},{"id":"GO:0008306","count":3},{"id":"GO:1903608","count":3}]},{"hash":"2013959666042803686","title":"Bioluminescence and Growth Metabolism","description":"This cluster centers on light-related functions (bioluminescence, photoprotection, chromophore linkage) alongside general growth and energy processes (energy generation, ribosome biogenesis, cell cycle/division, and ER polarization). The mixture suggests proteins linked to light-emitting metabolism that also participate in growth and division machinery. Confidence: Medium","confidence":"","size":11,"edges":28,"triangles":25,"max_degree":8,"top_function":"generation of precursor metabolites and energy","top_go_terms":[{"id":"GO:0018298","count":3},{"id":"GO:0010117","count":3},{"id":"GO:0008218","count":3},{"id":"GO:0006091","count":3},{"id":"GO:0007049","count":3}]},{"hash":"359198987422931504","title":"Cell signaling and tissue development","description":"The proteins in this cluster map to a broad set of GO terms spanning cell cycle regulation (kinetochore localization, CDK activity), neuronal development and synaptic function (cerebellar cortex development, excitatory postsynaptic potential), growth factor signaling (PDGF-related responses), extracellular matrix remodeling, muscle differentiation, and immune-related processes. This mix points to signaling pathways that govern development and structural remodeling across different tissues rather than a single, cohesive function. Therefore, a label centered on signaling and tissue development is most representative.","confidence":"Medium","size":11,"edges":33,"triangles":40,"max_degree":9,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0034501","count":11},{"id":"GO:0045736","count":11},{"id":"GO:0090648","count":10},{"id":"GO:0021695","count":10},{"id":"GO:0097350","count":10}]},{"hash":"1650479621814395691","title":"RNA Processing and RNA Silencing","description":"The dominant GO terms cluster around RNA maturation and post-transcriptional regulation (primary miRNA processing, spliceosomal snRNP assembly, regulatory ncRNA-mediated silencing, and dsRNA-to-siRNA processing), which together point to RNA processing and RNA interference pathways. Ubiquitination and DNA damage\u2013related terms may reflect broader regulatory context, while a couple of terms (dopamine response, feminization of germ-line) seem less connected and likely annotation noise. Overall, the cluster appears to represent RNA processing and silencing mechanisms.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045071","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0006977","count":2},{"id":"GO:0006351","count":2},{"id":"GO:1903351","count":2}]},{"hash":"853370167129761433","title":"Unknown","description":"The top GO terms span transcription regulation, metabolism of xenobiotics, redox processes, photoprotection/bioluminescence, energy generation, cell division (spindle assembly), apoptosis, and immune tolerance, with no clear shared function. The network is sparse (Max Degree 1, no triangles) and several terms are obsolete, indicating the proteins do not form a cohesive functional cluster.","confidence":"","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0046232","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0018298","count":2},{"id":"GO:0010117","count":2}]},{"hash":"154887237487768595","title":"Ribosome biogenesis and RNA processing","description":"The top GO terms strongly point to maturation of rRNA (5.8S and LSU/SSU) and RNA exon ligation, which are core steps in ribosome biogenesis and RNA processing. While there are some transcription-related terms present, the dominant signal is ribosome assembly-related processes, suggesting the cluster mainly comprises proteins involved in rRNA maturation and related RNA processing activities. Confidence: High","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000466","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1831654139192633599","title":"Unknown","description":"The GO terms associated with this cluster are extremely diverse (cell division; regulation of necroptotic process; photoprotection and bioluminescence; metabolism; dsRNA response; cocaine response; T cell cytotoxicity) and there are no connecting features or interactions to unify them. One term is obsolete, and the cluster has no edges, suggesting annotation noise rather than a cohesive biological function. Therefore, there isn\u2019t a clear, interpretable label beyond Unknown.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0060546","count":2},{"id":"GO:0018298","count":1},{"id":"GO:0010117","count":1},{"id":"GO:0008218","count":1}]},{"hash":"1521432593853283401","title":"Unknown","description":"The top GO terms cover heart development, immune defense, pain, temperature response, ERK signaling, metabolism, and inflammatory regulation, with no single unifying function tying them together. The cluster has no edges and highly diverse terms, suggesting either annotation noise or heterogeneous, multifunctional proteins rather than a coherent pathway. ","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":10},{"id":"GO:0042742","count":10},{"id":"GO:0019233","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0070374","count":10}]},{"hash":"2290474405803495064","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms cluster around developmental biology across multiple tissues and organs (heart/embryonic cushions, placenta, cartilage, palate, pancreas), indicating a common theme of embryonic development and morphogenesis rather than a single molecular function.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003198","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0060707","count":3}]},{"hash":"405840706188160094","title":"DNA Transposition and Proviral Integration","description":"The proteins cluster around GO terms for DNA integration, DNA transposition, retrotransposition, and proviral latency, with additional signals for viral entry into the host nucleus; this indicates a coherent theme centered on mobile genetic elements and viral integration processes, despite a few unrelated terms. ","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":6},{"id":"GO:0006313","count":6},{"id":"GO:0075713","count":5},{"id":"GO:0032197","count":5},{"id":"GO:0075732","count":5}]},{"hash":"895435531335472502","title":"DNA replication and transcription machinery","description":"Dominant GO terms are centered on DNA replication and DNA-templated transcription, with related processes like DNA topology changes, primer synthesis, and unwinding. Nonsense-mediated decay and SOS response reflect genome maintenance, and a few development terms appear incidental rather than defining the cluster. ","confidence":"Medium","size":11,"edges":13,"triangles":2,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0007118","count":5},{"id":"GO:0048701","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0000184","count":3}]},{"hash":"834277032167368752","title":"Growth-factor receptor signaling and angiogenesis","description":"This cluster centers on signaling pathways driven by receptor tyrosine kinases for growth factors such as PDGF, VEGF, and HGF, with associated processes like coronary artery morphogenesis and integrin-mediated signaling. These terms collectively point to angiogenesis and vascular development governed by growth-factor receptor signaling, making this the most coherent functional theme for the proteins in this cluster. While some immune-related terms appear, they are less representative of the core function here.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":7},{"id":"GO:0048008","count":6},{"id":"GO:0048010","count":6},{"id":"GO:0045880","count":6},{"id":"GO:0048632","count":6}]},{"hash":"2029820872011529832","title":"EMT and cytoskeletal regulation during development","description":"The cluster centers on cell migration, cytoskeletal reorganization (actin and microtubules), and changes in signaling pathways (notably Wnt) during development, including ectoderm formation and EMT-like processes. The combination of actin/microtubule regulation, cell adhesion-associated remodeling, and regulation of cell cycle and apoptosis aligns with migratory, EMT-driven developmental programs.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0016477","count":8},{"id":"GO:0008285","count":8},{"id":"GO:0043065","count":8},{"id":"GO:0090090","count":8},{"id":"GO:0007050","count":8}]},{"hash":"304262787307198297","title":"Viral DNA integration and latency","description":"The GO terms cluster around viral genome integration, reverse transcription\u2013related DNA biosynthesis, DNA replication, and proviral latency establishment, along with host entry and apoptosis interactions, pointing to a viral life-cycle/latency theme.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0006278","count":3},{"id":"GO:1903704","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0006310","count":3}]},{"hash":"2270546992915790585","title":"Neuroendocrine Regulation of Blood Pressure","description":"The cluster centers on neuropeptide signaling, dopamine signaling, vasopressin- and renin-regulated blood pressure, and cAMP-mediated signaling, indicating a cohesive role in neuroendocrine control of cardiovascular function. Immune-related terms appear, but the dominant theme ties to hormonal and neuronal regulation of blood pressure and related signaling pathways.","confidence":"High","size":11,"edges":9,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":11},{"id":"GO:0032651","count":11},{"id":"GO:0007218","count":11},{"id":"GO:2000724","count":11},{"id":"GO:0090075","count":11}]},{"hash":"1403963645556415992","title":"Embryonic development signaling","description":"The top GO terms cluster around embryogenesis and developmental signaling: brain development, gastrulation, FGF receptor signaling, and epithelial cell proliferation, indicating a role in embryonic development and tissue patterning. A weaker link to secretory trafficking (ER-Golgi transport) may accompany developing tissues, suggesting a developmental signaling/trafficking theme. ","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0031954","count":2},{"id":"GO:0007369","count":2},{"id":"GO:0045743","count":2}]},{"hash":"30872958585451841","title":"Synapse Assembly and Cytoskeletal Dynamics","description":"This cluster shows enrichment for GO terms related to synapse assembly, vesicle fusion, long-term potentiation, and reelin signaling, plus actin and microtubule cytoskeleton organization. The recurring theme is neuronal synapse development and remodeling, with components involved in trafficking and cytoskeletal rearrangements that shape synaptic connections. A few terms (egg activation, defense to fungus, sarcomere organization) are less aligned and may reflect annotation noise or broader roles; however the dominant pattern supports a label focused on synaptic formation and cytoskeletal regulation.","confidence":"Medium","size":11,"edges":50,"triangles":125,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007416","count":3},{"id":"GO:0007343","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0050832","count":2},{"id":"GO:2000249","count":2}]},{"hash":"305161737164585963","title":"Neuroendocrine control of blood pressure","description":"The terms strongly point to neuropeptide signaling and regulation of cardiovascular function, including vasopressin- and renin-mediated blood pressure control, plus related neuroendocrine regulation of vascular tone and dopaminergic signaling. Immune-related terms appear but the core theme centers on hormonal and neural regulation of blood pressure and vascular function.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":11},{"id":"GO:0032651","count":11},{"id":"GO:0007218","count":11},{"id":"GO:2000724","count":11},{"id":"GO:0090075","count":11}]},{"hash":"972369953803682052","title":"Neuropeptide-Driven Cardiovascular Signaling","description":"The cluster's top GO terms point to neuropeptide signaling and neuroendocrine control of cardiovascular processes, including vasopressin-regulated blood pressure, renin secretion, and dopamine uptake in synaptic transmission, along with muscle relaxation and smooth muscle differentiation. While there are inflammatory signal terms (e.g., cytokine and chemokine production), the prevailing theme is neural/peptide signaling that modulates vascular and cardiac function.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":7},{"id":"GO:0032651","count":7},{"id":"GO:0007218","count":7},{"id":"GO:2000724","count":7},{"id":"GO:0090075","count":7}]},{"hash":"1075931410433249604","title":"Temperature- and osmotic-stress response cluster","description":"The terms cluster around cellular responses to temperature and osmotic stress (temperature stimulus, thermogenesis, osmotic-stress\u2013induced apoptosis) with supplementary signals for circadian rhythm and broader physiological processes, implying a partial theme of stress-responsive regulation rather than a single highly specific function.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0002024","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0019228","count":2}]},{"hash":"1317021512216848555","title":"Ubiquitination and Autophagy Regulation","description":"Most terms point to ubiquitin-mediated regulation (ubiquitin-dependent ERAD, protein autoubiquitination) and autophagy, with inflammatory signaling (TNF-mediated) and antiviral transport regulation linking to immune responses. Some terms appear unrelated or deprecated, but the core theme is protein quality control via ubiquitination and autophagy in cellular stress and immune contexts.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1903265","count":6},{"id":"GO:0060669","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0051865","count":6},{"id":"GO:1901536","count":6}]},{"hash":"46207606302777680","title":"Embryonic development and tissue differentiation","description":"The terms center on neural development (ventral spinal cord interneuron fate commitment/differentiation and neuronal stem cell maintenance) but also include broader morphogenesis across skin, bone, vasculature, and heart valves, along with stem cell regulation and inflammatory context. This suggests a developmental differentiation signature across multiple tissues rather than a single pathway, justifying the label. ","confidence":"Medium","size":11,"edges":18,"triangles":5,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0060579","count":4},{"id":"GO:0045669","count":4},{"id":"GO:0021514","count":4},{"id":"GO:0097150","count":4}]},{"hash":"964775024463112403","title":"Neural development and Wnt/Hippo signaling","description":"Many terms converge on developmental signaling and neuronal differentiation (neuron development, regulation of synaptic plasticity, Wnt signaling, Hippo signaling), with additional hints of growth control (cell cycle, apoptosis) across tissues. This suggests a cluster centered on developmental signaling networks that influence neural differentiation and synaptic modulation.","confidence":"Medium","size":11,"edges":19,"triangles":11,"max_degree":6,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0000082","count":7},{"id":"GO:0060044","count":7},{"id":"GO:0030216","count":7},{"id":"GO:0090263","count":7},{"id":"GO:0006915","count":7}]},{"hash":"1003801171927228398","title":"Retroviral DNA integration and replication","description":"The GO terms chiefly indicate retroviral cycle features: proviral latency establishment, DNA integration into the host genome, viral entry into the nucleus, and RNA-templated DNA synthesis, along with DNA replication and recombination. Some symbiont-related terms appear, but the core theme is viral DNA metabolism and integration within the host.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":8},{"id":"GO:0075713","count":5},{"id":"GO:0075732","count":5},{"id":"GO:0039651","count":5},{"id":"GO:0046718","count":5}]},{"hash":"1220699092948650255","title":"Brassinosteroid biosynthesis","description":"The cluster is strongly represented by GO terms tied to brassinosteroid biosynthesis, specifically ent-kaurene oxidation to kaurenoic acid and brassinosteroid biosynthetic process, which are key steps in BR diterpene production. Although there are additional, more diverse terms (lipid metabolism, xenobiotic processing, etc.), the BR-related terms provide a coherent theme that points to brassinosteroid/diterpene metabolism as the core function of this cluster.","confidence":"High","size":11,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0046232","count":9},{"id":"GO:0032259","count":9},{"id":"GO:0006641","count":9},{"id":"GO:0070989","count":9},{"id":"GO:0060065","count":9}]},{"hash":"1400647200042614323","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0010587","count":2},{"id":"GO:0030260","count":2}]},{"hash":"1014508417426428095","title":"Cofactor Biosynthesis and Stress Response","description":"The cluster includes GO terms for molybdopterin and thiamine biosynthesis (cofactors) alongside responses to xenobiotics, antibiotics, and oxidative stress (menadione) and nitric oxide signaling, suggesting proteins involved in cofactor biosynthesis with broader defense/stress-related roles. The terms are related but span multiple functions, so the label reflects a general theme rather than a single precise pathway.","confidence":"Medium","size":11,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006777","count":1},{"id":"GO:0007263","count":1},{"id":"GO:0042493","count":1},{"id":"GO:0045880","count":1},{"id":"GO:0043418","count":1}]},{"hash":"1460785087609300580","title":"Transposable elements and proviral integration","description":"The GO terms cluster around DNA transposition, DNA integration, and retrotransposition, pointing to activity of transposable elements and proviruses. The presence of proviral latency and viral entry/penetration terms reinforces the link to viral genome integration and host interactions, while references to cell cycle and mRNA stability suggest effects on host cellular processes. Overall this cluster reflects mobile genetic elements (DNA transposons/retrotransposons) and proviral integration events.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0046718","count":3},{"id":"GO:0006310","count":2}]},{"hash":"1232882199626781034","title":"Unknown","description":"The GO terms are highly diverse, spanning transcription regulation, RNA modification, stress responses, various biosynthetic processes, metabolism, and several developmental pathways; there is no single cohesive function or pathway tying these terms together, suggesting a heterogeneous mix rather than a core cluster function.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0002098","count":3},{"id":"GO:0035902","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0009102","count":3}]},{"hash":"1204167570702101964","title":"Neuronal Signaling and Sensory Processing","description":"The terms point to neural communication and sensory function: ion transmembrane transport (Na+, K+), GABA signaling, excitatory/inhibitory postsynaptic potentials, and sensory modalities such as sound and taste aversion, plus linked behaviors like locomotion and responses to drugs. This suggests a cohesive cluster of proteins involved in synaptic transmission and neural signaling with sensory processing. ","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0001661","count":4},{"id":"GO:0007626","count":4},{"id":"GO:0007214","count":4}]},{"hash":"1756168444054433746","title":"Vascular remodeling and smooth muscle development","description":"The most represented themes point to vascular biology: smooth muscle cell migration and proliferation, endothelial chemotaxis regulation, and blood coagulation, indicating a cluster of proteins involved in blood vessel formation and remodeling. The presence of skeletal system development may reflect bone-vascular interactions, and oxidant detoxification suggests general cellular defense. A few terms about neural development appear as potential outliers not central to vascular function.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0097150","count":7},{"id":"GO:0014909","count":7},{"id":"GO:0001501","count":7},{"id":"GO:0098869","count":7}]},{"hash":"1776465608746005773","title":"Adhesion-driven neural and vascular morphogenesis","description":"The cluster centers on cell\u2013cell adhesion and receptor clustering, with multiple GO terms for homophilic/heterophilic adhesion and synapse assembly, plus axon guidance. Several terms also point to vascular and skeletal morphogenesis (aorta, coronary arteries, venous differentiation, valve morphogenesis). Together, these suggest proteins that mediate adhesion to drive tissue morphogenesis in neural and vascular contexts.","confidence":"High","size":11,"edges":3,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043113","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0007156","count":4},{"id":"GO:0048846","count":4}]},{"hash":"1045593763083174524","title":"Mitochondria-regulated synaptic function","description":"The proteins show mitochondrial assembly roles (complex IV, respirasome) alongside neural signaling and secretion processes (neurotransmitter transport, synaptic vesicle exocytosis, regulation of neurotransmitter secretion, synaptic plasticity) and metabolic shuttles. This pattern points to mitochondria coordinating energy and metabolism with neurotransmission and secretion, so a label emphasizing mitochondria-driven synaptic function fits well.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":2},{"id":"GO:0097250","count":1},{"id":"GO:0090201","count":1},{"id":"GO:0031915","count":1},{"id":"GO:0006836","count":1}]},{"hash":"740187750439268598","title":"Developmental signaling and vesicle trafficking","description":"This cluster\u2019s top GO terms highlight two connected themes: intracellular vesicle transport (retrograde Golgi-to-ER transport; cytoplasm-to-vacuole targeting) and signaling pathways involved in development and guidance (Roundabout signaling, axon guidance, ERK cascade, nervous system development). While there are also broader developmental terms (spermatid development, ossification, mast cell chemotaxis), the shared emphasis on signaling and trafficking linked to development suggests a cohesive, albeit broad, functional theme. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":3},{"id":"GO:0032258","count":3},{"id":"GO:0007286","count":3},{"id":"GO:0035385","count":3},{"id":"GO:0007411","count":3}]},{"hash":"314501006220263711","title":"Embryonic organ morphogenesis and transcription regulation","description":"The top GO terms cluster around morphogenesis of organs (eye, lung) and body patterning (left/right), together with transcription by RNA polymerase II and its negative regulation. This suggests proteins that coordinate embryonic tissue development through transcriptional control, spanning both organogenesis and patterning processes.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048745","count":3},{"id":"GO:0060441","count":3},{"id":"GO:0006366","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0048048","count":3}]},{"hash":"1676506483294499557","title":"Unknown","description":"The top GO terms are scattered across transcription regulation, insect sensory organ development (antennal and photoreceptor), and assorted metabolic/protein-processing processes, offering no clear shared function or pathway linking the 11 proteins. With no connectivity evidence, a cohesive cluster label cannot be confidently assigned.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010744","count":2},{"id":"GO:0045316","count":1},{"id":"GO:0007469","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0006351","count":1}]},{"hash":"1755545205066359891","title":"Embryonic organogenesis and immune signaling","description":"Shows a blend of developmental processes (kidney/metanephric tubule morphogenesis, mesonephric duct development, cartilage condensation) with immune-related activities (complement activation via lectin pathway, basophil and platelet activation, phagocytosis recognition, NK cell chemotaxis regulation, arachidonate signaling). The overlapping GO terms suggest proteins at the interface of embryonic organ formation and immune modulation, rather than a single canonical pathway.","confidence":"Medium","size":11,"edges":17,"triangles":6,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001867","count":10},{"id":"GO:0090238","count":9},{"id":"GO:0001502","count":9},{"id":"GO:0006910","count":9},{"id":"GO:0072177","count":9}]},{"hash":"2061799079516593626","title":"Neuropeptide Signaling and Cardiovascular Regulation","description":"The top GO terms center on neuropeptide signaling, vasopressin-mediated blood pressure regulation, renin secretion, and dopamine uptake in synaptic transmission, all pointing to a neuroendocrine control of cardiovascular function. Additional terms about muscle relaxation and regulation of chemokines/IL-1\u03b2 production suggest accompanying inflammatory signaling modulation. Together, these indicate a cluster of proteins involved in neuroendocrine regulation of cardiovascular homeostasis with linked immune signaling.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":11},{"id":"GO:0032651","count":11},{"id":"GO:0007218","count":11},{"id":"GO:2000724","count":11},{"id":"GO:0090075","count":11}]},{"hash":"776118689800156317","title":"Cardiac development and conduction system","description":"The top GO terms cluster around heart formation and the cardiac conduction system, including outflow tract morphogenesis, left ventricular morphogenesis, Purkinje-to-ventricular signaling, and regulation of SA node and atrial action potentials. While some terms touch on broader development (skin, bone ossification), the strongest and most frequent signals point to cardiac morphogenesis and electrical activity, supporting this label.","confidence":"High","size":11,"edges":15,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0086029","count":3},{"id":"GO:0003151","count":3},{"id":"GO:0098907","count":3}]},{"hash":"149767166533733147","title":"Neural Crest Migration and Axon Guidance","description":"The cluster is dominated by GO terms describing neural crest cell migration and neural development, including ventral trunk neural crest migration, autonomic nervous system\u2013related neural crest migration, sympathetic ganglion development, and GnRH neuron migration. It also features axon guidance signaling, with commissural neuron axon guidance and semaphorin-plexin pathways, plus Hedgehog pathway regulation (positive regulation of Smoothened signaling) that supports developmental signaling crosstalk. A retina vasculature morphogenesis term appears but the overarching theme remains neural crest\u2013driven neural development and axon guidance.","confidence":"High","size":11,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045880","count":1},{"id":"GO:1902378","count":1},{"id":"GO:0036486","count":1},{"id":"GO:0061549","count":1},{"id":"GO:0061299","count":1}]},{"hash":"1320566728166831759","title":"Unknown","description":"The GO terms cover DNA transposition, several RNA modification processes (RNA capping, guanine methylation), and also cell cycle/proliferation plus peroxisome import and protein quality control. There isn't a clear, single functional theme linking these terms for all proteins in the cluster, and with edges at zero, it likely reflects annotation noise or a heterogeneous set rather than a cohesive pathway.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":2},{"id":"GO:0034599","count":1},{"id":"GO:0016558","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0007049","count":1}]},{"hash":"1909447199343273747","title":"Germline Development and Stem Cell Regulation","description":"The dominant themes are development and germline differentiation (spermatid differentiation, male germ-line cyst formation) and stem cell maintenance, with supporting transcriptional and translational control (RNA polymerase II/III transcription, cap-dependent initiation). Lung development also fits the broad organogenesis context. Some terms (fear response, autophagy regulation) are less cohesive, but overall the cluster centers on developmental regulation and germline biology.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006384","count":1},{"id":"GO:0006366","count":1},{"id":"GO:0000082","count":1},{"id":"GO:0001662","count":1},{"id":"GO:0048515","count":1}]},{"hash":"392783024775160881","title":"Mechanotransduction and endosomal trafficking","description":"The cluster\u2019s top GO terms cluster around sensing mechanical cues (cellular response to mechanical stimulus), cytoskeletal remodeling (filopodium assembly), and membrane trafficking (plasma membrane to endosome transport, endosomal vesicle fusion), with Rap signaling and ubiquitination indicating coordinated regulation of signaling and protein turnover. This suggests a unified theme of mechanotransduction linked to vesicle trafficking and cytoskeletal dynamics. Some terms (hair follicle morphogenesis, hepatocyte apoptotic process) may reflect broader or context-specific processes but do not dominate the signature. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0048227","count":2},{"id":"GO:0032486","count":2},{"id":"GO:0010745","count":2},{"id":"GO:0046847","count":2}]},{"hash":"2304239081580963340","title":"Amino acid transport and neural signaling","description":"The top GO terms cluster around transport of amino acids across membranes (arginine, lysine, ornithine; D-serine) and neural-related processes (positive regulation of synapse assembly, thermosensory behavior, D-serine transmembrane transport). This suggests a set of membrane transporters linked to neural signaling and synaptic function. Some angiogenesis/VEGF-related terms appear, which may reflect broad regulatory roles or neurovascular coupling, but the dominant theme is amino acid transport tied to neural activity. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":2},{"id":"GO:1900747","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0042942","count":1},{"id":"GO:0097638","count":1}]},{"hash":"1439915363531406515","title":"Mitochondrial Metabolism and Transport","description":"GO terms cluster around mitochondrial energy metabolism and substrate transport (malate-aspartate shuttle; alpha-ketoglutarate and ornithine transmembrane transport; responses to insulin, fatty acids, and amino acid starvation). Protein heterooligomerization fits mitochondrial enzyme complexes, and even the fission-related term hints at mitochondrial dynamics. Together, they point to a cohesive theme of mitochondrial metabolism and transport.","confidence":"High","size":11,"edges":13,"triangles":1,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1903070","count":3},{"id":"GO:0051291","count":3},{"id":"GO:0043490","count":2},{"id":"GO:0070542","count":2},{"id":"GO:0034198","count":2}]},{"hash":"803110117000250409","title":"Developmental transcription regulation","description":"The top terms are dominated by transcriptional regulation (RNA polymerase II activity, DNA-templated transcription) and regulatory RNA-mediated silencing, with additional development-related terms (brain development, trophoblast differentiation, fibroblast proliferation). This points to a shared theme of controlling gene expression in developmental contexts, despite some miscellaneous terms. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":3},{"id":"GO:0031047","count":2},{"id":"GO:2000616","count":2},{"id":"GO:0048146","count":2},{"id":"GO:0060707","count":2}]},{"hash":"1775031357880542124","title":"Neural Synaptic Transmission and Ion Transport","description":"This cluster centers on neuronal communication, with GO terms highlighting ion transmembrane transport (sodium, potassium) and synaptic signaling (excitatory/inhibitory postsynaptic potentials, GABA pathway). Additional terms related to behavior and drug responses (locomotory behavior, conditioned taste aversion, cocaine, nicotine) suggest involvement in neural circuits governing movement and reward, reinforcing a theme of neural signaling and excitability. Overall, the proteins appear to participate in ion-channel\u2013driven synaptic transmission and related behaviors.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":11},{"id":"GO:0060079","count":11},{"id":"GO:0001661","count":11},{"id":"GO:0007626","count":11},{"id":"GO:0007214","count":11}]},{"hash":"296698802607396479","title":"APC/C-Mediated Mitotic Ubiquitination","description":"The prominent GO terms center on the anaphase-promoting complex (APC/C)-dependent catabolic process, K11-linked ubiquitination, and the mitotic cell cycle, pointing to proteins involved in ubiquitin-mediated targeting of mitotic regulators to ensure proper cell division. While a few single-occurrence terms (synaptic potentiation, cadmium response, photosynthesis) are present, they do not define the cluster\u2019s core function. This makes \u201cAPC/C-Mediated Mitotic Ubiquitination\u201d a precise and representative label.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031145","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0051301","count":2},{"id":"GO:1903646","count":1}]},{"hash":"812010403125073636","title":"Chromatin Remodeling and Cytoskeletal Control of Cell Division","description":"Top GO terms indicate coordinated control of transcription, chromatin state via histone acetylation, and mitotic processes, with Arp2/3-driven actin dynamics supporting cytokinesis. This suggests a cohesive role in regulating gene expression and chromatin structure during cell division and development, aligning with the observed terms for transcription, cell cycle, histone modification, and cytoskeletal remodeling.","confidence":"High","size":10,"edges":34,"triangles":58,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0043982","count":3},{"id":"GO:0034314","count":3}]},{"hash":"378586768525759352","title":"RNA processing and ribosome biogenesis","description":"The dominant terms relate to RNA processing and quality control (splicing regulation, ncRNA-mediated silencing, mRNA decay, tRNA surveillance) plus ribosome biogenesis (mitochondrial large subunit assembly and rRNA maturation). This combination points to a cluster of RNA metabolism and ribosome assembly functions.","confidence":"High","size":10,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":5},{"id":"GO:0031047","count":5},{"id":"GO:2000623","count":3},{"id":"GO:1902775","count":3},{"id":"GO:0071038","count":3}]},{"hash":"2137963027817730943","title":"Regulators of Cellular Trafficking and Signaling","description":"The terms cluster around regulation of intracellular transport and signaling processes, including nucleocytoplasmic transport, mRNA transport, vesicle fusion, mitochondrial calcium, apoptosis, GTPase activity, and kinase regulation. This suggests a coherent function as regulators coordinating trafficking and signaling rather than a single pathway.","confidence":"Medium","size":10,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043065","count":2},{"id":"GO:0051561","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0051028","count":2},{"id":"GO:0043547","count":2}]},{"hash":"798304491470364871","title":"Developmental cytoskeleton dynamics","description":"This cluster centers on developmental processes (heart and brain development, dorsal closure, T cell polarity) and actin-related cytoskeleton remodeling (negative regulation of actin filament severing, muscle filament sliding), suggesting a theme of cytoskeletal dynamics during development. Some terms like DNA replication and glomerular filtration are present but do not override the overarching link to development and actin regulation.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0007512","count":3},{"id":"GO:1903919","count":3},{"id":"GO:0003094","count":3},{"id":"GO:0046663","count":3}]},{"hash":"325046742204443558","title":"Cerebellar neural structure and microtubule dynamics","description":"The cluster features GO terms tied to cerebellar layer structural organization (granular and Purkinje layers) alongside microtubule-related processes (spindle midzone, nuclear migration along microtubules, plus-end-directed microtubule sliding) and dendritic transport of neurotransmitter receptors, suggesting a shared role in cerebellar neuronal architecture and microtubule-dependent transport/dynamics.","confidence":"Medium","size":10,"edges":25,"triangles":24,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0048364","count":9},{"id":"GO:0021685","count":7},{"id":"GO:0000742","count":7},{"id":"GO:0051255","count":7},{"id":"GO:0030473","count":7}]},{"hash":"1762267645804972066","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0043045","count":1},{"id":"GO:0003149","count":1},{"id":"GO:0010452","count":1},{"id":"GO:0051571","count":1}]},{"hash":"1649205679024865194","title":"Retroviral integration and latency","description":"The top GO terms point to reverse transcription (RNA-templated DNA synthesis), DNA integration and recombination, viral entry into the host nucleus, and proviral latency, together with DNA replication\u2014all characteristic of the retroviral life cycle. Some terms about host RNAi defense and symbiont interactions appear as ancillary context, but the core theme is retroviral genome processing and latency.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006278","count":4},{"id":"GO:1903704","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0006310","count":4}]},{"hash":"1709631858492010205","title":"Viral DNA integration and proviral latency","description":"The top GO terms cluster around DNA-level processes typical of viral or transposon life cycles: DNA integration, establishment of proviral latency, RNA-templated DNA biosynthesis (reverse transcription), DNA recombination, and DNA transposition, plus viral entry into the host nucleus. The negative regulation of siRNA processing also suggests viral manipulation of host RNA interference. Together these indicate a theme centered on viral genome integration/latency and transposon-like genome rearrangements.","confidence":"High","size":10,"edges":32,"triangles":44,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0075713","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0006278","count":2},{"id":"GO:1903704","count":2}]},{"hash":"1558548291828619102","title":"Unknown","description":"The GO terms cover very different areas (positive regulation of JNK signaling, bone resorption, ribosome biogenesis, photoprotection, energy metabolism, hair follicle morphogenesis, chemotaxis, and intracellular protein transport), with no single overarching function tying the proteins together, so the cluster does not map to a cohesive biological theme.","confidence":"","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046330","count":2},{"id":"GO:0045453","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0018298","count":1},{"id":"GO:0010117","count":1}]},{"hash":"2141383128112285490","title":"Ribosome biogenesis and translation","description":"The top GO terms cluster around protein synthesis and ribosome assembly\u2014translation, ribosome biogenesis (including small subunit biogenesis), translational termination, and tRNA modification, with selenocysteine incorporation pointing to specialized translation. A few terms about antibiotic response and cell cycle appear subtler, but the dominant theme is ribosome function and amino acid decoding.","confidence":"High","size":10,"edges":36,"triangles":64,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0000288","count":2},{"id":"GO:0042274","count":2}]},{"hash":"1395851242371922825","title":"Actin filament assembly and contractile ring","description":"This cluster is dominated by GO terms related to actin dynamics: actin filament polymerization, actin filament bundle assembly, and mitotic actomyosin contractile ring assembly, indicating cytoskeletal assembly and contractility. Other terms touch on growth and muscle development, suggesting broad cytoskeletal remodeling across tissues. The few obsolete or peripheral terms do not override the central theme.","confidence":"High","size":10,"edges":17,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001300","count":3},{"id":"GO:0030476","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0001895","count":3},{"id":"GO:0048741","count":3}]},{"hash":"67685606734774117","title":"T cell signaling and cytoskeletal dynamics","description":"This cluster is marked by GO terms linking T cell receptor signaling, ephrin signaling, and small GTPase\u2013mediated pathways, along with actin remodeling processes such as actin filament branching, filopodium and podosome assembly, and synapse structural plasticity. The convergence of immune signaling and cytoskeletal reorganization strongly points to proteins that couple receptor activation to actin-driven changes, i.e., T cell signaling coordinated with cytoskeletal dynamics. ","confidence":"High","size":10,"edges":25,"triangles":22,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0090135","count":3},{"id":"GO:0051835","count":3},{"id":"GO:0046847","count":3}]},{"hash":"640492911730914312","title":"Protein acetylation and polyamine catabolism","description":"The top GO terms cluster around post-translational modifications (N-terminal acetylation, acetylation of histones, propionylation) and polyamine metabolism (putrescine and spermine catabolic processes), suggesting a cohesive theme of protein modification linked to metabolic turnover, with a few outliers like dormancy and angiogenesis that are less central to the core function.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0085014","count":2},{"id":"GO:0006950","count":2},{"id":"GO:0043967","count":2},{"id":"GO:0060358","count":1},{"id":"GO:0046208","count":1}]},{"hash":"1269899751264094308","title":"Neural signaling and metabolic regulation","description":"The cluster\u2019s terms cluster around neural signaling and metabolism: GABA shunt, neuromuscular control, olfactory pit development, and responses to nutrients and cAMP, with glucosylceramide metabolism pointing to lipid processing relevant to neural tissue. Although a couple of development terms (e.g., pancreas) extend beyond neural contexts, the overall theme ties neural signaling to metabolic regulation. ","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060166","count":10},{"id":"GO:0051591","count":10},{"id":"GO:0006069","count":10},{"id":"GO:1901023","count":10},{"id":"GO:0006540","count":10}]},{"hash":"157565129130443992","title":"Unknown","description":"The top terms span stress and defense responses (dsRNA, cadmium ion), photosynthesis, and various regulatory processes, with several entries marked obsolete, showing no single, coherent function tying the 10 proteins together. Therefore, a specific, representative label cannot be determined.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071360","count":6},{"id":"GO:1903646","count":6},{"id":"GO:0051348","count":6},{"id":"GO:1902391","count":6},{"id":"GO:2001162","count":6}]},{"hash":"486358434254002980","title":"Neural development and immune signaling","description":"The top terms include DNA-templated transcription, immune-related responses (GM-CSF stimulus, LPS response, T cell receptor signaling), neural development features (axonogenesis, long-term potentiation, excitatory postsynaptic potential), and development/apoptosis regulation. This combination suggests a cluster of proteins that link transcriptional control with immune signaling and neural development/synaptic plasticity. Confidence: Medium","confidence":"","size":10,"edges":7,"triangles":1,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0097011","count":8},{"id":"GO:0050852","count":8},{"id":"GO:0071222","count":8},{"id":"GO:0000278","count":7}]},{"hash":"297764056401631465","title":"Innate Immunity and Pyroptosis Regulation","description":"The top GO terms center on innate immune signaling and inflammatory cell death: innate immune response, NOD2 signaling pathway, and pyroptotic inflammatory response, together with protein ubiquitination and apoptosis. Some terms like mitotic spindle assembly and maintenance of cell polarity appear less directly connected, suggesting a set of multifunctional proteins that participate in immune signaling and cell death regulation rather than a single, cohesive pathway.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":5},{"id":"GO:0006915","count":4},{"id":"GO:0045087","count":4},{"id":"GO:1990001","count":3},{"id":"GO:0090307","count":3}]},{"hash":"1124583369360245960","title":"Neural development and axon guidance","description":"The strongest signals are axon guidance and neural connectivity (commissural axon guidance, sympathetic neuron projection guidance, branchiomotor neuron axon guidance, axon extension, vestibulocochlear nerve organization). A related theme is synaptic vesicle endocytosis, with circadian regulation as a secondary neuronal function. Together, these terms point to proteins coordinating neural wiring and synaptic function.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:1900242","count":5},{"id":"GO:0042748","count":5},{"id":"GO:0061549","count":4},{"id":"GO:0071679","count":4},{"id":"GO:0061302","count":4}]},{"hash":"1781605298835713143","title":"Macrophage innate immunity and NLRP3 inflammasome signaling","description":"The terms cluster around macrophage activation, TLR4 signaling, regulation of IL-18 and IL-1 production, interferon production, and NLRP3 inflammasome assembly, with defense against virus and actin remodeling. This points to a cohesive theme of innate immune sensing and inflammasome-driven cytokine responses in macrophages.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042116","count":3},{"id":"GO:0032741","count":3},{"id":"GO:0050711","count":3},{"id":"GO:0034142","count":3},{"id":"GO:0045356","count":3}]},{"hash":"1980373037362051068","title":"Multisystem Signaling and Trafficking","description":"The terms converge on diverse cell signaling routes (Rho and integrin signaling; IFN signaling) and on trafficking/organellar processes (endosome size) that influence apoptosis, bone development, and neural communication. Together they suggest a broad, multisystem signaling and trafficking theme rather than a single, cohesive function.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0060348","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0060335","count":2},{"id":"GO:0006915","count":2}]},{"hash":"724592623209891612","title":"Stress-response and epigenetic regulation","description":"This cluster features GO terms tied to cellular response to exogenous dsRNA and cadmium stress, plus terms related to protein modification, histone methylation, and acetylation, suggesting a group of proteins involved in stress signaling and transcriptional/epigenetic regulation. Although several terms are obsolete, the common thread appears to be stress response linked to RNA sensing and chromatin-based control of gene expression.","confidence":"Medium","size":10,"edges":20,"triangles":9,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0071360","count":2},{"id":"GO:1903646","count":2},{"id":"GO:0051348","count":2},{"id":"GO:1902391","count":2},{"id":"GO:2001162","count":2}]},{"hash":"1820462729712303378","title":"Embryonic neural and skeletal development with stress responses","description":"The cluster\u2019s strongest signals are embryonic development terms (multicellular organism development, neural tube closure, forebrain development, skeletal system development), suggesting a core theme of developmental processes. The co-occurrence of stress/defense terms (cadmium response, ER stress\u2013related apoptosis, defense response to Gram-positive bacteria) indicates these proteins may also participate in stress- or immune-related regulation that intersects with development. Overall, the label emphasizes embryonic neural/skeletal development while acknowledging accompanying stress-related signals.","confidence":"Medium","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0090307","count":4},{"id":"GO:0071276","count":4},{"id":"GO:0006349","count":4}]},{"hash":"50521746872778265","title":"Skeletal muscle fiber development and sarcomere assembly","description":"GO terms center on skeletal muscle development, sarcomere organization, and actin cytoskeleton assembly (e.g., skeletal muscle fiber development; actin filament bundle assembly; sarcomere organization). This suggests the proteins may participate in muscle cell differentiation and the assembly of contractile structures via actin remodeling. Some terms like substantia nigra development and inter-male aggressive behavior appear in the set but are less directly connected to muscle function, indicating possible annotation spillover or multifunctional roles; overall the cluster seems to reflect muscle cytoskeleton and sarcomere\u2013related processes.","confidence":"Medium","size":10,"edges":11,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0051017","count":2},{"id":"GO:0009825","count":2},{"id":"GO:1904623","count":2}]},{"hash":"1452960509000974910","title":"Unknown","description":"The terms span stress response (oxidative stress, cocaine), metabolism (sterol biosynthesis), protein trafficking (ER-Golgi transport, peroxisome import), and basic cell processes (DNA replication, mitotic cell cycle, mRNA capping); there is no single evident function linking all proteins, so a cohesive label cannot be justified.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042220","count":4},{"id":"GO:0034599","count":3},{"id":"GO:0016558","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006260","count":3}]},{"hash":"963039282448100325","title":"Brain development and dopaminergic neuron differentiation","description":"Proteins in this cluster are enriched for brain-related developmental terms, especially midbrain development and dopaminergic neuron differentiation, suggesting a core role in neural development and neuronal specification. While there are a few outlier terms (e.g., gonadal and uterus development), the dominant signal points to neural development and transcriptional regulation in this context. ","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0030901","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0008584","count":6},{"id":"GO:0021983","count":6}]},{"hash":"1480675320477004764","title":"Cardiac signaling and calcium handling","description":"This cluster features GO terms centered on heart development, regulation of cardiac muscle contraction, cAMP/adenylate cyclase signaling, calcium release into the cytosol, and protein phosphorylation. Together they point to a module of proteins coordinating cardiac excitation-contraction coupling through phosphorylation and GTPase regulation, with calcium and cAMP signaling as core themes. A single outlier like visual perception is likely noise; overall a cardiac signaling/calcium-handling theme best fits.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":9},{"id":"GO:0071502","count":9},{"id":"GO:0008284","count":9},{"id":"GO:0006468","count":9},{"id":"GO:0007507","count":9}]},{"hash":"1624599070375910850","title":"Actin Cytoskeleton and Cell Junction Development","description":"This cluster is dominated by actin-focused terms\u2014actin filament bundle assembly and actomyosin structure organization\u2014with cell-cell junction organization as well, all within various developmental contexts (ectoderm, phloem, cervix development). The common thread appears to be cytoskeletal remodeling and junctional dynamics essential for developmental processes.","confidence":"High","size":10,"edges":41,"triangles":90,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0010088","count":5},{"id":"GO:0090334","count":5},{"id":"GO:0045216","count":5},{"id":"GO:0060067","count":5},{"id":"GO:0010735","count":5}]},{"hash":"1275733064742423390","title":"Pain perception and skin development cluster","description":"This cluster is dominated by GO terms for sensory perception of pain, skin development, morphine response, and multicellular organism development, pointing to a theme of sensory signaling linked to tissue development. Additional terms like diet-induced thermogenesis and cell proliferation suggest broader metabolic and growth regulation, but the strongest shared signal among the top terms is pain-related signaling coupled with tissue development, especially skin. ","confidence":"Medium","size":10,"edges":15,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":6},{"id":"GO:0007275","count":5},{"id":"GO:0071502","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0051260","count":4}]},{"hash":"594001841715700169","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071031","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006368","count":1},{"id":"GO:0000290","count":1},{"id":"GO:0033147","count":1}]},{"hash":"97188574656921435","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0035372","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0051092","count":5},{"id":"GO:2000653","count":4},{"id":"GO:0007014","count":4}]},{"hash":"346285725882280101","title":"Antiviral innate immune response","description":"The cluster shows strong representation of GO terms for cellular response to exogenous dsRNA, cellular response to type I interferon, and innate immune response, indicating antiviral immune function. Some terms like photosynthesis and cell division appear as less-related annotations, suggesting a few outliers, but the dominant signal is innate antiviral immunity.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0071360","count":10},{"id":"GO:0071357","count":10},{"id":"GO:0045087","count":10},{"id":"GO:0050689","count":10},{"id":"GO:0051301","count":10}]},{"hash":"2047617464967569584","title":"Unknown","description":"The top GO terms span immune signaling, peptide transport regulation, sperm flagellar assembly, DNA repair and cell-cycle checkpoints, neuron development, meiotic telomere organization, transcriptional regulation under hypoxia, and both error-free and error-prone translesion synthesis. This broad mix shows no single cohesive biological function or pathway tying the proteins together, so there isn\u2019t a clear, representative cluster label beyond Unknown.","confidence":"","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0050852","count":10},{"id":"GO:0090089","count":10},{"id":"GO:0007288","count":10},{"id":"GO:0045739","count":10},{"id":"GO:0010976","count":10}]},{"hash":"2240598830655626261","title":"Golgi-ER trafficking and SNARE assembly","description":"These terms cluster around vesicle transport between the ER and Golgi, Golgi ribbon formation, and SNARE complex assembly, pointing to a core function in vesicular trafficking and membrane fusion at the Golgi/ER. A few additional terms relate to signaling or context-specific processes, but the dominant pattern supports a Golgi/ER trafficking and SNARE machinery theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048280","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0070542","count":3},{"id":"GO:0032869","count":3}]},{"hash":"1282617997027316361","title":"Tissue remodeling and vascular signaling","description":"The GO terms cluster around adhesion (endothelial and matrix), prostaglandin biosynthesis, coagulation, decidualization, BMP signaling, vitamin D response, and immune-related processes like phagocytosis, suggesting a theme of tissue remodeling with vascular and immune signaling rather than a single, tight pathway. This broad, cohesive theme fits the mix of terms while acknowledging some outliers. ","confidence":"Medium","size":10,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":3},{"id":"GO:0071603","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0006511","count":2},{"id":"GO:0007161","count":2}]},{"hash":"587639976157533820","title":"Neural development, synaptic regulation, and vascular remodeling","description":"The top GO terms point to neuronal development and synaptic functions (axon extension, synapse assembly, synaptic plasticity), while also highlighting vascular and muscular regulatory processes (coronary morphogenesis, endothelial chemotaxis, smooth muscle contraction) and general regulatory activities (cell-substrate adhesion, alkaline phosphatase activity). This suggests a cohesive theme of regulation across neural development and cardiovascular/muscular systems, hence the label tying neural and vascular remodeling together.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010811","count":3},{"id":"GO:0048632","count":3},{"id":"GO:0048846","count":3},{"id":"GO:0031915","count":3},{"id":"GO:0045987","count":3}]},{"hash":"1494857549044858973","title":"Mitochondrial Metabolism and Transport","description":"The terms together point to mitochondrial-focused functions: transport of metabolites and ions (alpha-ketoglutarate, malate, ornithine, manganese), the malate-aspartate shuttle, and mitochondrial membrane fission processes, plus cellular responses to metabolic cues (insulin, fatty acids, amino acid starvation). This suggests a cohesive cluster centered on mitochondrial metabolism and membrane dynamics rather than disparate pathways.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060546","count":3},{"id":"GO:0043490","count":2},{"id":"GO:0070542","count":2},{"id":"GO:0034198","count":2},{"id":"GO:0000066","count":2}]},{"hash":"63052219259010428","title":"ECM Remodeling and Vascular Morphogenesis","description":"The terms cluster around extracellular matrix remodeling (collagen catabolic process; glomerular basement membrane development) and tissue morphogenesis (cartilage development in bone morphogenesis; aorta smooth muscle and other vascular-related morphogenesis) as well as cell adhesion. These collectively point to ECM organization and development of vascular/connective tissues, with some ancillary immune signals (complement activation, T cell proliferation) that are common in remodeling contexts. Overall, the dominant theme is ECM remodeling linked to vascular and tissue morphogenesis.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:1901492","count":3},{"id":"GO:0032836","count":3},{"id":"GO:1903225","count":2},{"id":"GO:0030574","count":2}]},{"hash":"331174045721340830","title":"Mitosis and cell cycle regulation","description":"The dominant GO terms point to core mitotic processes: spindle assembly, sister chromatid cohesion, APC-dependent catabolic activity, and regulation of meiotic division, indicating a cluster centered on cell division control. Supporting terms like actin filament remodeling and nuclear pore localization align with cytoskeletal and transport changes during mitosis. Some terms (obsolete ERAD, lens differentiation) are less clearly related, but the core signal is mitosis/cell cycle control with related growth signaling (TORC1). Overall, the cluster most plausibly represents proteins involved in mitosis and cell-cycle regulation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":4},{"id":"GO:0007064","count":3},{"id":"GO:0040020","count":3},{"id":"GO:1904263","count":3},{"id":"GO:0030042","count":3}]},{"hash":"448960647747865648","title":"Diverse Stimulus-Response Signaling and Synapse Organization","description":"The top terms point to proteins involved in responding to a variety of cues (vitamin D, estradiol, VEGF, mechanical and fungal origin) and in signaling-related processes (prostaglandin biosynthesis, receptor clustering, and synapse assembly), suggesting a theme of stimulus-driven signaling with possible roles in synaptic organization and cell communication.","confidence":"Medium","size":10,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0001516","count":3},{"id":"GO:0007416","count":3},{"id":"GO:0043113","count":3}]},{"hash":"1545585447658391786","title":"Glycan and lipid biosynthesis","description":"The cluster centers on synthesis of sugar- and glycan-containing structures (starch, glycogen, sucrose metabolism; glycosylation and GPI-anchor biosynthesis; protein glycosylation in ER) and membrane lipids (phospholipid biosynthesis), with bacillithiol biosynthesis adding a sugar-derived protective molecule. Together these terms indicate a cohesive theme of building glycan- and lipid-containing macromolecules. ","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0072708","count":4},{"id":"GO:0019252","count":4},{"id":"GO:0005985","count":4},{"id":"GO:0097502","count":4},{"id":"GO:0005978","count":4}]},{"hash":"2289646061844245467","title":"Vascular ECM Remodeling and Coagulation","description":"The top GO terms point to extracellular matrix components and remodeling (proteoglycans, elastic fibers, cell-matrix adhesion, plasminogen activation) and vascular/coagulation processes (blood coagulation, fibrin clot formation, vasoconstriction, angiogenesis regulation). Together they describe a module of ECM remodeling linked to vascular function and coagulation, with some ancillary surface localization and immune activity terms.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030210","count":4},{"id":"GO:0045907","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0048251","count":4},{"id":"GO:0034394","count":4}]},{"hash":"2058070730624506680","title":"Lipid and hormone metabolism","description":"Most terms are related to biosynthesis and metabolism of lipid-derived hormones and signaling molecules, such as testosterone biosynthesis, androgen metabolism, prostaglandin biosynthesis, and triglyceride metabolism. Some outlier terms (carbazole catabolic process, ent-kaurene oxidation, methylation, cellular response to potassium, uterus development) appear not tightly connected to this theme, suggesting possible annotation noise or broad cross-functional annotations. Overall, the dominant theme points to lipid/hormone production and processing.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061370","count":3},{"id":"GO:0008209","count":3},{"id":"GO:0046232","count":2},{"id":"GO:0032259","count":2},{"id":"GO:0006641","count":2}]},{"hash":"1077613659086699615","title":"Cell signaling with autophagy and cell cycle regulation","description":"The cluster includes terms tied to signaling pathways (Wnt signaling, even an obsolete PI3K note), regulation of autophagy, transcription control, and cell cycle processes, along with related responses like mechanical stimuli and myelination. While some terms are broad, the recurring theme is regulation of cellular signaling that influences growth, differentiation, and proliferation, with autophagy as a connected process.","confidence":"Medium","size":10,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0016239","count":2}]},{"hash":"1009040939769532748","title":"Vascular Inflammation and Foam Cell Formation","description":"The top GO terms cluster around immune activation and inflammatory signaling (immunological synapse formation; acute inflammatory response; cytokine production) together with macrophage-driven lipid uptake and foam cell differentiation, efferocytosis, and endothelial/ECM remodeling (fibronectin fibril organization, cholesterol storage, endothelial cell proliferation). This combination points to a vascular inflammatory milieu linked to lipid handling and foam cell formation, characteristic of early and ongoing atherogenic processes. The oxidative/post-translational modification terms are supportive but secondary. ","confidence":"High","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001771","count":8},{"id":"GO:0043277","count":8},{"id":"GO:1900017","count":8},{"id":"GO:0002438","count":8},{"id":"GO:0010744","count":8}]},{"hash":"1249327697730635648","title":"Paranodal axon guidance and neural crest migration","description":"The top GO terms point to paranodal junction assembly and localization to paranode/juxtaparanode regions, plus multiple neuron projection guidance events (including neural crest\u2013derived structures and cranial nerves). This suggests a cohesive function in paranodal organization and axon pathfinding with supporting cell adhesion themes.","confidence":"High","size":10,"edges":5,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030913","count":5},{"id":"GO:0002175","count":4},{"id":"GO:0071205","count":4},{"id":"GO:0097490","count":4},{"id":"GO:0097491","count":4}]},{"hash":"2120392270296823916","title":"Innate Immune Signaling and Inflammation","description":"The top GO terms cluster around macrophage activation, NOD2 and TLR4 signaling, NF-\u03baB regulation, pyroptosis, IL-18 production, protein ubiquitination, and xenophagy, all pointing to innate immune sensing and inflammatory responses. Although a couple terms are broad or regulatory (e.g., catalytic activity regulation, obsolete NF-\u03baB term), the dominant theme is immune activation and pathogen-directed responses, including autophagic clearance and inflammatory cell death.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":3},{"id":"GO:0042116","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0070431","count":3},{"id":"GO:0034142","count":2}]},{"hash":"1761339708072360304","title":"Neuronal development and axon guidance","description":"The cluster is enriched for brain development, ROBO (roundabout) signaling, excitatory postsynaptic potential, actin filament branching, and Rap-mediated signal transduction, all of which fit a coherent theme of neural development, axon pathfinding, and synaptic signaling. While xenobiotic response and respiratory burst terms appear, the dominant pattern centers on neuronal differentiation, cytoskeletal remodeling, and synaptic connectivity.","confidence":"High","size":10,"edges":36,"triangles":60,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031069","count":10},{"id":"GO:0050919","count":10},{"id":"GO:0090316","count":10},{"id":"GO:0090135","count":10},{"id":"GO:0032486","count":10}]},{"hash":"961313928914071982","title":"Ubiquitin-Mediated Mitotic Regulation","description":"This cluster prominently features GO terms tied to mitosis and ubiquitination: APC-dependent proteolysis, mitotic cell cycle, and general cell division, along with K11-linked ubiquitination. These point to regulation of protein degradation during cell cycle. Although there are antiviral response terms (defense response to virus, response to exogenous dsRNA), they are less central to the core pattern; the strongest signals describe ubiquitin-based control of mitosis, which justifies the label. Some terms are obsolete but do not change the functional theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2001162","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0031145","count":3},{"id":"GO:0070979","count":3}]},{"hash":"1309682502455280883","title":"Glutamatergic Synapse Assembly and Transmission","description":"Based on the GO terms, the dominant theme is neuronal synapses, especially glutamatergic signaling (sensory perception of sound, synapse assembly, and glutamatergic transmission) with related neuronal connectivity processes (dopaminergic axon guidance, cell\u2013cell junctions). Some heart-related terms appear, but the neural synaptic functions are the strongest signal, supporting a label for glutamatergic synaptic development and signaling.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":4},{"id":"GO:0007416","count":3},{"id":"GO:0035249","count":3},{"id":"GO:1903263","count":2},{"id":"GO:0086073","count":2}]},{"hash":"336369849124972730","title":"Endocytosis and actin remodeling in immune cells","description":"The top terms point to endocytosis and actin cytoskeleton processes (filopodium and actin bundle assembly), plus dendritic cell chemotaxis and Rac/PI3K signaling, which together suggest cytoskeleton-driven endocytic trafficking and immune cell migration/signaling. Although heart development and growth hormone secretion appear, the dominant theme is cytoskeletal dynamics linked to endocytosis and immune cell behavior.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0051017","count":2},{"id":"GO:1900042","count":2},{"id":"GO:0060124","count":2}]},{"hash":"982676370206373429","title":"Embryonic neural development and metabolic cofactors","description":"The top GO terms show emphasis on in utero embryonic development and neuron maturation, complemented by several metabolic cofactor pathways (thiamine, lipoate, tetrahydrofolate, 2-oxoglutarate). This suggests proteins involved in neural development that rely on core metabolic support, with apoptosis likely reflecting normal developmental remodeling.","confidence":"Medium","size":10,"edges":5,"triangles":1,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001701","count":7},{"id":"GO:0042551","count":6},{"id":"GO:0006915","count":6},{"id":"GO:0043046","count":6},{"id":"GO:0009228","count":5}]},{"hash":"1160015007030562431","title":"Dopaminergic Neuron Development and Synaptic Plasticity","description":"The cluster shows enrichment for terms tied to neural development and synaptic function: dopaminergic neuron differentiation, axon and dendrite development, regulation of synaptic vesicle endocytosis, and synapse structural plasticity. Sensory-system related terms like cochlea morphogenesis further point to development of neural circuits in sensory organs. This combination supports a label focused on maturation of dopaminergic neurons and synaptic regulation.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":3},{"id":"GO:0090103","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0045773","count":2},{"id":"GO:1904948","count":2}]},{"hash":"1283607852442480571","title":"Ubiquitin-Dependent Proteolysis and NF-\u03baB Signaling","description":"The terms point to ubiquitin-mediated protein degradation (ubiquitin-dependent proteolysis, K6-linked ubiquitination) and NF-\u03baB pathway regulation (I\u03baB phosphorylation, TNF signaling). This suggests a cluster of proteins functioning in ubiquitin-regulated turnover and inflammatory signaling, with V(D)J recombination and chromatin modification terms appearing as broader, less specific connections. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0033151","count":7},{"id":"GO:2000620","count":7},{"id":"GO:1903762","count":7},{"id":"GO:1903265","count":7}]},{"hash":"38077998301796326","title":"Vertebrate development and tissue patterning","description":"The terms point to broad developmental roles across multiple tissues (heart and skeletal development; motor neuron guidance and synapse assembly; myeloid differentiation; convergent extension), suggesting proteins involved in vertebrate development and tissue organization rather than a single pathway. Hence, \u201cVertebrate development and tissue patterning\u201d is a concise, representative label.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097350","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0038091","count":2},{"id":"GO:0008045","count":2}]},{"hash":"128946586564457762","title":"Chromatin remodeling during replication and meiosis","description":"The top GO terms cluster around chromatin silencing/heterochromatin formation, pre-replicative complex assembly and replication initiation, and meiotic processes (premeiotic and meiotic replication, meiotic recombination nodules, telomere silencing). This suggests a common theme of chromatin regulation linked to DNA replication and meiosis. Some terms (photosynthesis, gas vesicle organization, xenobiotic response) are outliers, likely annotation noise, but do not override the core chromatin/replication signal.","confidence":"Medium","size":10,"edges":10,"triangles":2,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030466","count":3},{"id":"GO:0015979","count":3},{"id":"GO:0006267","count":3},{"id":"GO:0031412","count":3},{"id":"GO:0042140","count":3}]},{"hash":"568175908726643232","title":"Retinal development and vision","description":"The top terms show a clear emphasis on photoreceptor morphogenesis and visual perception, pointing to a cluster of proteins involved in retina development and visual function. Other terms (e.g., hypoxia response, DNA transposition) are present but far less represented, making the overall theme strongly tied to vision with some noise.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008594","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0006313","count":1},{"id":"GO:0001935","count":1}]},{"hash":"325147281538555118","title":"Neuronal ion channels and synaptic signaling","description":"The cluster's top GO terms cluster around ion transmembrane transport (sodium, potassium, calcium), membrane depolarization, and synaptic activity (excitatory postsynaptic potential, GABA signaling). This, plus sensory-related terms (sound perception, locomotory behavior, conditioned taste aversion), points to proteins involved in neuronal signaling and sensory processing via ion channels and neurotransmitter pathways.","confidence":"High","size":10,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":8},{"id":"GO:0060079","count":8},{"id":"GO:0071805","count":8},{"id":"GO:0001661","count":7},{"id":"GO:0007626","count":7}]},{"hash":"1089519599453585459","title":"Developmental cell-adhesion and cytoskeleton remodeling","description":"This cluster\u2019s GO terms center on cell-cell adhesion and regulation of actin and microtubule networks, with supporting hints from tissue- and organogenesis-related terms (ectoderm and metanephros morphogenesis, Purkinje/His tissue). The mix suggests proteins coordinating adhesion signals with cytoskeletal remodeling during development.","confidence":"Medium","size":10,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0015991","count":4},{"id":"GO:0086073","count":3},{"id":"GO:0090138","count":3},{"id":"GO:1904501","count":3},{"id":"GO:0044334","count":3}]},{"hash":"59057740140456267","title":"Neuronal development and signaling with remodeling","description":"Several top GO terms point to neuronal development and signaling (cerebellar cortex development; excitatory postsynaptic potential; potassium ion transport), suggesting a neural function focus. Additional terms touch growth factor response (PDGF), extracellular matrix disassembly, and muscle differentiation, implying coordinated development and tissue remodeling across lineages rather than a single tissue.","confidence":"Medium","size":10,"edges":13,"triangles":3,"max_degree":5,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006813","count":10},{"id":"GO:0090648","count":9},{"id":"GO:0021695","count":9},{"id":"GO:0097350","count":9},{"id":"GO:0060079","count":9}]},{"hash":"709165008548951641","title":"RNA processing and mRNA export","description":"The top GO terms center on mRNA export from the nucleus, various mRNA processing steps (splicing, decay, maturation), and rRNA processing. Although a couple terms suggest plant developmental processes, the prevailing theme is RNA maturation and nuclear export.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016973","count":2},{"id":"GO:0009553","count":2},{"id":"GO:0001829","count":2},{"id":"GO:0000447","count":2},{"id":"GO:0098789","count":2}]},{"hash":"2107622591016894002","title":"Embryonic morphogenesis and cell migration","description":"This cluster centers on developmental tissue formation across multiple systems (bone remodeling, aorta and valve morphogenesis, optic vesicle morphogenesis, neural crest migration, retinal axon guidance) with associated cell adhesion and signaling (focal adhesion regulation, substrate adhesion-dependent spreading, tyrosine phosphorylation). The common theme is morphogenesis coupled with coordinated cell movements and adhesion signaling during development.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046849","count":3},{"id":"GO:1903849","count":2},{"id":"GO:0050731","count":2},{"id":"GO:0001755","count":2},{"id":"GO:0003180","count":2}]},{"hash":"161043196397637616","title":"Neural Crest Migration and Axon Guidance with Vascular Morphogenesis","description":"This cluster centers on neural-development processes: neural crest cell migration (ventral trunk neural crest migration), sympathetic ganglion development, and commissural neuron axon guidance, alongside vascular morphogenesis (branching in blood vessel morphogenesis, retina vasculature morphogenesis). The co-occurrence of these GO terms suggests a cohesive theme of neural crest\u2013driven development that coordinates neural wiring with vessel formation. Some terms are broad or obsolete, but the core signal remains neural development and vascular morphogenesis.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050919","count":1},{"id":"GO:0090648","count":1},{"id":"GO:0010811","count":1},{"id":"GO:0001569","count":1},{"id":"GO:1902378","count":1}]},{"hash":"1856246070496222084","title":"Golgi-ER-lysosome protein trafficking","description":"The terms converge on intracellular transport and localization through the secretory pathway, including Golgi localization, ER exit regulation, Golgi-to-plasma membrane transport, and endosome-Golgi routing, with lysosomal targeting also represented. Some terms (e.g., mating behavior, I-kappaB phosphorylation) seem less related and may reflect annotation noise, but the dominant signal describes Golgi- and endosome-associated trafficking processes.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006622","count":2},{"id":"GO:0007252","count":1},{"id":"GO:0060625","count":1},{"id":"GO:0048047","count":1},{"id":"GO:0043001","count":1}]},{"hash":"2171758358185335038","title":"Proton-Driven Transport and Energy Production","description":"The top GO terms are dominated by proton transmembrane transport, proton motive force-driven ATP synthesis, vacuolar acidification, and sodium ion transport, which together point to membrane energy metabolism and ion homeostasis as the core theme. A few terms reference nuclear processes (mRNA export, transcription regulation, DNA replication) and stress granule localization, which may reflect broader housekeeping roles or annotation spillover rather than a single cohesive function. Overall, the cluster appears anchored in membrane energetics and ion transport, with ancillary nuclear-related annotations.","confidence":"Medium","size":9,"edges":31,"triangles":56,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":2},{"id":"GO:0019629","count":2},{"id":"GO:0006626","count":2},{"id":"GO:0006814","count":2},{"id":"GO:0007035","count":2}]},{"hash":"159710163701718238","title":"Ribosome biogenesis and RNA splicing","description":"The cluster is dominated by GO terms for ribosome assembly (large subunit biogenesis, preribosome assembly, mitochondrial large subunit assembly) and multiple RNA processing steps (splicing, exon ligation, mRNA catabolic processes, and splicing regulation), along with stress granule localization. A few terms referencing neuronal signaling appear as minor nuances, but the core theme ties ribosome biogenesis to RNA metabolism and mRNA fate, suggesting these proteins collaborate in coordinating ribosome production with RNA processing.","confidence":"High","size":9,"edges":10,"triangles":5,"max_degree":4,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042273","count":5},{"id":"GO:1902626","count":5},{"id":"GO:0000398","count":5},{"id":"GO:1990416","count":5},{"id":"GO:0000378","count":4}]},{"hash":"2032648843375626948","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071042","count":2},{"id":"GO:0071038","count":2},{"id":"GO:0000467","count":2},{"id":"GO:0071035","count":2},{"id":"GO:2000627","count":2}]},{"hash":"1879313817936722109","title":"Gene expression regulation and innate immune signaling","description":"The top GO terms cluster around regulation of transcription and RNA processing (positive regulation of transcription by RNA polymerase II, ncRNA-mediated gene silencing, positive regulation of mRNA splicing), suggesting a theme of gene-expression control. At the same time, terms related to immune/touchpoints (cellular response to lipopolysaccharide, Fc receptor signaling) and stress-related processes (phosphatidylserine exposure in apoptosis, autophagy regulation, cholesterol homeostasis) indicate engagement of innate immune signaling and cellular stress responses. Taken together, the cluster appears to blend gene-expression regulation with innate immune and stress-response pathways rather than a single, cohesive enzymatic function. ","confidence":"Medium","size":9,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0001300","count":2},{"id":"GO:2000373","count":2}]},{"hash":"1745681890081474682","title":"RNA processing and translation regulation","description":"This cluster centers on post-transcriptional RNA processing and controls of translation, with terms for spliceosome-mediated splicing, mRNA export, mRNA stability under stress, and translation initiation/silencing.","confidence":"High","size":9,"edges":7,"triangles":4,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":4},{"id":"GO:0048026","count":3},{"id":"GO:0075525","count":3},{"id":"GO:0035278","count":3},{"id":"GO:0031047","count":3}]},{"hash":"843363944861126342","title":"Unknown","description":"The top GO terms cover a mix of metabolism (arginine, glucosamine, spermine), RNA processing and transcription/chromatin functions (spliceosomal snRNP assembly, transcription elongation, histone methylation), protein modification (N-terminal acetylation), and vesicle transport, with no single unifying biological process that ties them together. This lack of a coherent theme suggests no clear cluster function can be assigned.","confidence":"","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006526","count":3},{"id":"GO:0000387","count":2},{"id":"GO:0080182","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0032968","count":2}]},{"hash":"1018049604734144681","title":"Protein quality control and folding","description":"The top terms center on proteostasis, including chaperone-dependent refolding, ER-associated degradation, and regulation of protein assembly and stress responses, suggesting a cluster of proteins involved in protein folding and quality control. Some terms are obsolete or unrelated (e.g., hormone response, neural patterning), but the cohesive theme around folding/quality control remains.","confidence":"Medium","size":9,"edges":34,"triangles":71,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071374","count":3},{"id":"GO:0032781","count":3},{"id":"GO:0051259","count":3},{"id":"GO:0070389","count":3},{"id":"GO:0006452","count":3}]},{"hash":"155321656800135568","title":"Retroviral integration and DNA transposition","description":"The cluster is dominated by terms about DNA integration, retrotransposition, DNA transposition, proviral latency establishment, and viral entry into the host nucleus, plus DNA-templated transcription. This points to a coherent theme of mobile genetic element activity and retroviral-like integration/transposition machinery, with a few peripheral terms related to host-symbiont interactions that do not override the main function.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0032197","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0039651","count":2}]},{"hash":"1435242991944437408","title":"Neuropeptide signaling and blood pressure regulation","description":"The GO terms center on neuropeptide signaling, vasopressin-regulated blood pressure, renin secretion, and dopamine-related synaptic signaling, indicating a cluster of proteins involved in neuroendocrine control of cardiovascular function and vascular tone. While immune-related terms appear, the core pattern points to neural/hormonal modulation of blood pressure and related signaling pathways.","confidence":"High","size":9,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043950","count":1},{"id":"GO:0032651","count":1},{"id":"GO:0007218","count":1},{"id":"GO:2000724","count":1},{"id":"GO:0090075","count":1}]},{"hash":"1074162324219676007","title":"Apoptosis and Developmental Signaling","description":"The cluster is enriched for both positive and negative regulation of neuron apoptosis, along with regulation of Wnt signaling and differentiation processes, plus ubiquitin-dependent protein degradation. This combination suggests a cohesive role in controlling cell fate decisions during development and neural contexts, mediated by signaling pathways and controlled proteolysis, with some outliers likely reflecting broader regulatory functions.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0010796","count":2},{"id":"GO:0043525","count":2},{"id":"GO:0031384","count":2}]},{"hash":"1032734715179114671","title":"Multi-tissue Development and Immune Modulation","description":"The top GO terms point to development across several tissues (ventral spinal cord interneuron fate, pharynx, lateral mesoderm, smooth muscle, basal respiratory cells) while also including immune-related processes (interleukin-21 production, T cell tolerance induction, and regulation of inflammatory response). This suggests the cluster comprises proteins involved in broad developmental differentiation with concurrent roles in immune modulation, rather than a single tissue-specific function.","confidence":"Medium","size":9,"edges":20,"triangles":15,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060579","count":6},{"id":"GO:0019101","count":6},{"id":"GO:1901250","count":6},{"id":"GO:0048745","count":6},{"id":"GO:0060465","count":6}]},{"hash":"515155324479502103","title":"Microtubule-Driven Mitosis and Neuronal Transport","description":"The cluster prominently features GO terms tied to microtubule-based processes, including spindle assembly, DNA replication/recombination during mitosis, and nuclear migration along microtubules, along with neuron-specific transport and cerebellar structural organization terms. This points to a shared role in organizing microtubule networks for cell division and for neuronal transport/structure, justifying a label centered on microtubule-driven functions spanning both domains.","confidence":"Medium","size":9,"edges":26,"triangles":35,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000742","count":4},{"id":"GO:0006260","count":3},{"id":"GO:0006310","count":2},{"id":"GO:0021685","count":2},{"id":"GO:0051255","count":2}]},{"hash":"1855607617006789682","title":"Cardiac development and calcium signaling","description":"This cluster is dominated by GO terms tied to heart development and cardiac stress responses (heart development, cardiac muscle hypertrophy in response to stress), along with regulation of calcium-release channels (ryanodine receptor) and processes like angiogenesis and exocytosis, suggesting a cohesive theme around cardiac development and calcium signaling pathways.  ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":2},{"id":"GO:0014898","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0006469","count":2},{"id":"GO:0060316","count":2}]},{"hash":"1458192244959060498","title":"Unknown","description":"The top GO terms are highly diverse, including brain development, chromatin organization, DNA recombination and repair, collagen catabolic process, platelet aggregation, and interferon production, with no single shared function across the cluster. This heterogeneity suggests no coherent biological theme, so an Unknown label with confidence None is appropriate.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0035551","count":1},{"id":"GO:0034396","count":1},{"id":"GO:0034724","count":1},{"id":"GO:0070527","count":1}]},{"hash":"731937060217719624","title":"Neural and pituitary development with epigenetic regulation","description":"This cluster centers on brain and pituitary development, including brain and cerebral cortex development as well as pituitary gland development, and shows enrichment for transcriptional regulation and histone methylation (epigenetic control). While a few terms like CD8-positive T cell differentiation or single fertilization appear, the dominant theme is neuroendocrine development coupled with epigenetic regulation of transcription. ","confidence":"Medium","size":9,"edges":7,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":4},{"id":"GO:0007420","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0051573","count":3},{"id":"GO:0008584","count":3}]},{"hash":"241579078591681765","title":"Synapse Assembly and Receptor Signaling","description":"This cluster is driven by synapse assembly and receptor clustering, indicating neuronal synaptic organization. The additional terms for estradiol and VEGF responses, mechanical stimuli, and behavioral regulation suggest broader signal transduction and plasticity at synapses in response to hormonal, growth-factor, and environmental cues.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007416","count":3},{"id":"GO:0043113","count":3},{"id":"GO:0032355","count":3},{"id":"GO:0043065","count":3},{"id":"GO:0035924","count":3}]},{"hash":"1617998879654085463","title":"DNA replication and mitosis regulation","description":"The cluster shows strong representation of DNA replication (GO:0006260), mitotic processes (GO:0007064; GO:0031145), and DNA repair via homologous recombination (GO:0010569), pointing to cell cycle control and genome maintenance. While hypoxia and innate immune terms appear, they are likely secondary stress-associated signals, with the core theme centered on replication, chromosome cohesion, and mitosis/repair coordination.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001666","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0031145","count":2}]},{"hash":"1933490079083224079","title":"Embryonic Organogenesis and Morphogenesis","description":"The cluster is dominated by GO terms tied to embryonic development and organ formation, including in utero embryonic development, gastrulation, foregut morphogenesis, ureter development, and cardiac muscle cell proliferation, with supporting signals for gonadotropin hormone regulation. Although a couple of terms are obsolete histone ubiquitination entries, the core theme centers on embryonic organogenesis.","confidence":"High","size":9,"edges":6,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001701","count":5},{"id":"GO:0001702","count":4},{"id":"GO:0070535","count":3},{"id":"GO:0033092","count":3},{"id":"GO:0048617","count":3}]},{"hash":"1465222511210000800","title":"Mitochondrial Protein Import and Lipid Metabolism","description":"The top terms are dominated by mitochondrial-focused processes (import into the mitochondrial matrix, outer membrane insertion, and translation), pointing to a mitochondrial protein handling cluster. The accompanying lipid and vitamin A metabolism terms (retinol/vitamin A metabolism, ether lipids, phosphocholine, and adipose regulation) suggest an integrated role of mitochondria in lipid and vitamin A pathways. This combination supports labeling the cluster around mitochondrial protein import/translation with a lipid metabolism context.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0045040","count":1},{"id":"GO:0042572","count":1},{"id":"GO:0006776","count":1}]},{"hash":"805178632770478288","title":"Organogenesis and patterning","description":"The top GO terms point to embryonic development and organ formation across multiple tissues (ear, forebrain, pancreas, pituitary, thyroid, kidney), including pattern formation and regulation of gene expression, indicating proteins that collectively participate in organogenesis and tissue patterning rather than a single specialized function.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060118","count":2},{"id":"GO:0043049","count":2},{"id":"GO:0048505","count":2},{"id":"GO:0001658","count":2},{"id":"GO:0007275","count":2}]},{"hash":"1503846095520062385","title":"Unknown","description":"The GO terms are highly diverse (heme biosynthesis, methylation, granulocyte differentiation, cold response, cytolysis, xenobiotic response, glycerol catabolic process, histone methylation regulation, neural precursor proliferation, herbicide response), with no single coherent function tying the cluster together. Therefore no confident, representative label can be assigned.","confidence":"","size":9,"edges":10,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006782","count":3},{"id":"GO:0032259","count":2},{"id":"GO:0030851","count":2},{"id":"GO:0009409","count":2},{"id":"GO:0019835","count":2}]},{"hash":"205235793931391897","title":"DNA Repair and Transcription Regulation","description":"This cluster is mainly characterized by DNA repair terms (interstrand cross-link repair, recombinational repair) and transcription-related terms (regulation of DNA-templated transcription, DNA-templated transcription), suggesting a core theme of genome maintenance linked to gene expression control. Some other terms (mitochondrial translation and development) appear, likely representing annotation noise or pleiotropic roles rather than a cohesive functional module; however, the strongest signals point to DNA repair and transcription regulation.","confidence":"Medium","size":9,"edges":8,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0036297","count":1},{"id":"GO:0000733","count":1},{"id":"GO:0000002","count":1},{"id":"GO:0000725","count":1},{"id":"GO:0045316","count":1}]},{"hash":"1864940853178732658","title":"Neuronal lipid metabolism and neurotransmission","description":"This cluster centers on fatty acid oxidation and transport (beta-oxidation, acyl-CoA, carnitine metabolism), alongside acetylcholine biosynthesis and regulation of neurotransmitter secretion, plus endocrine signaling such as insulin secretion. The co-occurrence of lipid metabolic processes with neural signaling terms suggests a module where lipid energy metabolism supports or modulates neurotransmission and neuroendocrine regulation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032000","count":1},{"id":"GO:0033540","count":1},{"id":"GO:0008292","count":1},{"id":"GO:0019254","count":1},{"id":"GO:0001547","count":1}]},{"hash":"1562686405360315915","title":"Large subunit ribosome biogenesis","description":"This cluster is dominated by GO terms tied to ribosome production and maturation of the large ribosomal subunit, including large subunit export from the nucleus, LSU-rRNA processing, and assembly of the LSUB preribosome, indicating a cohesive role in LSU biogenesis.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0000463","count":1},{"id":"GO:1902626","count":1},{"id":"GO:0000466","count":1}]},{"hash":"270362365733619093","title":"Unknown","description":"The GO terms are highly heterogeneous, including cell division, chaperone-related folding, dsRNA response, histone methylation, metal/cadmium response, and photosynthesis, with several entries marked obsolete. There isn\u2019t a clear, cohesive theme tying these proteins to a single function, so a specific label cannot be confidently assigned.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0070389","count":2},{"id":"GO:0071360","count":2},{"id":"GO:1903646","count":2},{"id":"GO:0051348","count":2}]},{"hash":"1299244643095266546","title":"Innate Immune Signaling and NF-kB Regulation","description":"The top GO terms cluster around innate immune sensing pathways (TLR4 signaling, NOD2 signaling) and regulation of NF-kB activity, with ubiquitination linked to signaling and interferon production, pointing to a role in pattern-recognition receptor\u2013mediated inflammatory signaling rather than a cell-cycle process.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032088","count":5},{"id":"GO:0071260","count":5},{"id":"GO:0016567","count":5},{"id":"GO:0070431","count":5},{"id":"GO:0019800","count":3}]},{"hash":"1864225730626590999","title":"Ubiquitin-Dependent Mitosis and Spindle Assembly","description":"The top GO terms cluster around mitosis and ubiquitin-mediated regulation: mitotic cell cycle, cell division, mitotic spindle assembly, APC/C-dependent catabolic process, and protein ubiquitination (including K11-linked ubiquitination). These points suggest the proteins function in ubiquitin-driven control of mitosis and spindle dynamics. Some terms like innate immune response and hypoxia may be background signals, but do not define the main theme. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001162","count":2},{"id":"GO:0031145","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0000278","count":2}]},{"hash":"1347887219580672084","title":"Immune signaling and ECM remodeling","description":"Because the top GO terms cluster around inflammatory and antiviral signaling (inflammatory response, JNK and NF-kappaB pathways, interferon-beta production, response to dsRNA) and defense against bacteria) together with extracellular matrix interactions (integrin signaling, cell-matrix adhesion, hyaluronan metabolism, metallopeptidase activity), the proteins likely participate in coordinated immune activation with remodeling of the extracellular environment.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046330","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0007161","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0030212","count":3}]},{"hash":"1974747411323918621","title":"Secreted glycoproteins and lipid metabolism","description":"GO terms point to secreted and extracellular processes (immunoglobulin production, extracellular matrix constituent secretion), along with post-translational O-linked glycosylation and lipoprotein/lipid metabolism. This suggests a theme centered on secreted glycoproteins and glycosylation-associated lipid processing, but the presence of several unrelated or obscure terms (arabinose/arabininan metabolism, DNA ADP-ribosylation) makes the connection tentative. Low","confidence":"","size":9,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0002378","count":2},{"id":"GO:0070278","count":2},{"id":"GO:0031221","count":2},{"id":"GO:0018242","count":2},{"id":"GO:0046373","count":2}]},{"hash":"2056358922765744761","title":"Cytoskeleton organization and epithelial cell polarity","description":"These terms cluster around cytoskeletal organization (actin filament bundle assembly, spindle assembly) and establishment of epithelial cell polarity, with a related mechanotransduction signal (response to muscle stretch) and ancillary roles in vesicle trafficking and mitosis. Despite some obsolete terms, the core theme points to cytoskeleton remodeling and polarity maintenance.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098907","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0051225","count":3},{"id":"GO:0035994","count":3},{"id":"GO:0035544","count":3}]},{"hash":"629522917310679130","title":"Viral DNA Integration and Host Entry","description":"These proteins are enriched for GO terms tied to DNA replication, DNA integration, and RNA-templated DNA biosynthesis, consistent with retroviral or proviral life-cycle steps such as proviral latency establishment and viral penetration into the host nucleus. Additional terms about symbiont entry/activation of host processes and endocytic recycling suggest broader host\u2013pathogen interaction and trafficking roles. Overall, the cluster is best characterized by viral DNA integration and entry into host cells, with some host-defense and trafficking aspects.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0006278","count":3},{"id":"GO:1903704","count":3},{"id":"GO:0075713","count":3}]},{"hash":"226232923508662491","title":"Neural development signaling with cell cycle regulation","description":"Top GO terms point to neural development and CNS differentiation, including cerebellar cortex formation, Bergmann glial differentiation, and visual perception, as well as axon regeneration regulation. The presence of kinase activity regulation and negative regulation of cell proliferation, plus kinetochore localization, suggests a link to cell cycle control in developing neural tissue. The recurring signaling terms (T cell receptor, insulin receptor) highlight broader signaling context but do not override the CNS development theme, supporting a label that captures neural development signaling with some cell-cycle regulatory aspects.","confidence":"Medium","size":9,"edges":15,"triangles":10,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":8},{"id":"GO:0021697","count":8},{"id":"GO:0008285","count":8},{"id":"GO:0034501","count":8},{"id":"GO:0048679","count":8}]},{"hash":"285030051439557464","title":"Heart development and conduction system","description":"Most of the top GO terms describe heart development and cardiac electrical activity (multicellular organism development; Purkinje to ventricular signaling; outflow tract morphogenesis; regulation of SA node and atrial action potentials; left ventricular morphogenesis). Together they point to proteins involved in cardiac morphogenesis and electrophysiology. A few terms like ossification, skin development, and caffeine response are less central and may reflect broader developmental roles or annotation noise.","confidence":"High","size":9,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0086029","count":3},{"id":"GO:0003151","count":3},{"id":"GO:0098907","count":3},{"id":"GO:0097050","count":3}]},{"hash":"2245357035255431725","title":"Amino acid import across plasma membrane","description":"The cluster\u2019s top GO terms are dominated by amino acid transport across the plasma membrane, including L-arginine, L-lysine, and L-ornithine import, plus D-serine transport, which together point to a common function in amino acid uptake. While a couple of terms touch on cell migration and macrophage activation, the strongest and most coherent signal is amino acid transport/metabolism at the membrane. Some annotations are obsolete, but the core theme remains amino acid import. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":2},{"id":"GO:0007205","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0042116","count":1},{"id":"GO:0042942","count":1}]},{"hash":"1586536269696063245","title":"Unknown","description":"The GO terms span lipid metabolism (triglyceride and prostaglandin biosynthesis), xenobiotic catabolism (carbazole), methylation and oxidative demethylation, and plant hormone pathways (kaurene/brassinosteroid biosynthesis) alongside disparate processes like uterus development and inflammatory regulation. This mix points to no single coherent function tying all proteins together, so a generic Unknown label is appropriate.","confidence":"","size":9,"edges":9,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006641","count":3},{"id":"GO:0046232","count":2},{"id":"GO:0032259","count":2},{"id":"GO:0070989","count":2},{"id":"GO:0060065","count":2}]},{"hash":"1647040219216552508","title":"Motor neuron axon guidance and NMJ assembly","description":"The top GO terms cluster around motor neuron development and neuromuscular junction formation: peripheral nervous system neuron axonogenesis, motor neuron axon guidance, lateral motor column neuron migration, and synaptic assembly at the neuromuscular junction. Additional terms like cell-matrix adhesion support axon\u2013extracellular matrix interactions during guidance, while prostaglandin biosynthesis and PI3K/AKT signaling indicate signaling contexts that modulate neuronal connectivity and muscle innervation. Despite a couple of background terms, the dominant theme is motor neuron connectivity and NMJ formation.","confidence":"High","size":9,"edges":27,"triangles":44,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0048936","count":3},{"id":"GO:0070527","count":3},{"id":"GO:0008045","count":3}]},{"hash":"528020208616761332","title":"Retroviral genome integration and latency","description":"Most terms point to viral genome integration and the life cycle: DNA integration and proviral latency, reverse-transcribed DNA synthesis, recombination and replication, and entries/exits of the virus into and from the host nucleus. A few terms about host-symbiont interactions and siRNA processing may reflect host responses rather than core function. Overall, the cluster appears tied to viral genome integration and propagation.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0075713","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0006278","count":3},{"id":"GO:1903704","count":3}]},{"hash":"1085837353308672866","title":"Lipid metabolism regulation and GTPase signaling","description":"This cluster shows frequent GO terms tied to lipid-related pathways (sterol biosynthesis, fatty acid beta-oxidation, ceramide transport) and regulation of small GTPase signaling (Rho, Ral). The combination suggests a module focused on controlling lipid metabolism via signaling cascades. Some terms about heart contraction, microglial migration, and placenta development may reflect broader regulatory roles or pleiotropy in lipid signaling networks.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":3,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:0016126","count":6},{"id":"GO:0032000","count":6},{"id":"GO:0003108","count":6},{"id":"GO:0035621","count":6}]},{"hash":"1950296769226742879","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007494","count":2},{"id":"GO:0071377","count":1},{"id":"GO:1903718","count":1},{"id":"GO:0042594","count":1},{"id":"GO:0071320","count":1}]},{"hash":"1945585195531487270","title":"Glycosylation and carbohydrate biosynthesis","description":"The top GO terms point to carbohydrate metabolism (sorbitol, starch, sucrose, glycogen) along with glycosylation pathways (GPI anchor biosynthesis, protein glycosylation), indicating a cohesive theme around sugar processing and glycoprotein biosynthesis.","confidence":"High","size":9,"edges":13,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0072708","count":7},{"id":"GO:0019252","count":7},{"id":"GO:0005985","count":7},{"id":"GO:0097502","count":7},{"id":"GO:0005978","count":7}]},{"hash":"2291683309226620771","title":"Hematopoietic and epithelial differentiation","description":"Most terms describe differentiation of various lineages (granulocytes, dendritic cells, erythrocytes, megakaryocytes, goblet/epithelial cells) and related tissue remodeling, with some epigenetic regulation. The shared theme is guidance of cell fate across multiple lineages rather than a single process, justifying 'Hematopoietic and epithelial differentiation' as a concise label.","confidence":"Medium","size":9,"edges":7,"triangles":0,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030851","count":3},{"id":"GO:0060480","count":3},{"id":"GO:0044027","count":3},{"id":"GO:0097152","count":3},{"id":"GO:2000504","count":3}]},{"hash":"1275513632833847894","title":"Ventral spinal interneuron development","description":"The cluster is dominated by GO terms tied to neural development, especially ventral spinal cord interneuron differentiation and fate commitment (GO:0060579, GO:0021514). Negative regulation of Notch signaling (GO:0045746) also aligns with promoting neural differentiation. While a few terms touch on apoptotic cell recognition or immune responses and some entries are obsolete, the core theme points to spinal interneuron development and differentiation.","confidence":"High","size":9,"edges":27,"triangles":39,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0032496","count":3},{"id":"GO:0045746","count":3},{"id":"GO:0043654","count":3},{"id":"GO:0048333","count":3}]},{"hash":"1916174685971360730","title":"Neuronal development and dopamine metabolism","description":"The top GO terms cluster around neural development and neurotransmitter processing, notably dendrite morphogenesis, CNS neuron development, striatum development, and dopamine metabolic process, suggesting a group of proteins involved in neuronal differentiation and dopaminergic signaling. Some terms like salvage pathways and transcription are ancillary or broader, and an outlier like lactation may reflect cross-species data noise. Overall, the dominant theme is neural development with dopamine-related metabolism.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048813","count":3},{"id":"GO:0021954","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0019835","count":2},{"id":"GO:0021756","count":2}]},{"hash":"1650540452463961225","title":"Forebrain Development and Neural Fate Specification","description":"This cluster centers on brain development and regional neural patterning, including forebrain patterning (forebrain dorsal/ventral, forebrain-midbrain boundary) and habenula/pituitary development, plus neuronal fate commitment in the forebrain and transcriptional regulatory activity. The shared themes are neural development and neuronal specification, with some transcriptional regulation indicating control of gene expression during these processes.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":3},{"id":"GO:0000122","count":3},{"id":"GO:2000288","count":2},{"id":"GO:0021918","count":2},{"id":"GO:0007275","count":2}]},{"hash":"2072878476191884095","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":1},{"id":"GO:1904803","count":1},{"id":"GO:0006370","count":1},{"id":"GO:1904744","count":1},{"id":"GO:0031564","count":1}]},{"hash":"991607027803070610","title":"Mitochondrial Metabolism and Fission","description":"These proteins are tied to mitochondrial function: transport of key metabolites (alpha-ketoglutarate, ornithine) and ions (manganese, magnesium), the malate-aspartate shuttle, and mitochondrial membrane fission. The presence of metabolic-regulation terms (response to insulin, fatty acids, amino acid starvation) supports a broader mitochondrial metabolic role. Overall, a coherent theme around mitochondrial metabolite handling and division emerges.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043490","count":9},{"id":"GO:0070542","count":9},{"id":"GO:0034198","count":9},{"id":"GO:0000066","count":9},{"id":"GO:0015742","count":9}]},{"hash":"608560585309248534","title":"Unknown","description":"The top GO terms come from disparate biological areas (carbazole catabolic and oxidative demethylation xenobiotic metabolism; methylation; triglyceride metabolism; plant hormone pathways brassinosteroid and ent-kaurene oxidation; prostaglandin biosynthesis; uterus development; potassium ion response), with no shared function linking all proteins. The sparse connectivity (one edge, no triangles) suggests no coherent single function for this cluster.","confidence":"","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046232","count":5},{"id":"GO:0032259","count":5},{"id":"GO:0006641","count":5},{"id":"GO:0070989","count":5},{"id":"GO:0060065","count":5}]},{"hash":"2231321969465922338","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032232","count":1},{"id":"GO:1990145","count":1},{"id":"GO:0006414","count":1},{"id":"GO:0042753","count":1},{"id":"GO:0009585","count":1}]},{"hash":"2221867892083215056","title":"Pro-inflammatory Immune Signaling and Leukocyte Recruitment","description":"The top GO terms emphasize pro-inflammatory signaling, cytokine/chemokine production, platelet activation, and neutrophil recruitment/extravasation, pointing to a cluster of proteins that promote inflammation and leukocyte trafficking. A couple of terms (heart development, sodium transport) are less aligned, but the dominant signal is inflammatory immune regulation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010572","count":2},{"id":"GO:2000661","count":2},{"id":"GO:2000391","count":2},{"id":"GO:0002374","count":2},{"id":"GO:0090197","count":2}]},{"hash":"383867790310600149","title":"Neural development and brain formation","description":"The most represented terms point to neural development and brain formation, including brain development, forebrain development, neural tube closure, and sensory perception of sound, suggesting a nervous system development theme; a few terms (regulation of B cell differentiation, ectopic germ cell programmed cell death) are less coherent with this core theme and may reflect annotation noise.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0035234","count":2},{"id":"GO:0045577","count":2},{"id":"GO:0007420","count":2}]},{"hash":"1220433050033371968","title":"Neuronal signaling and calcium regulation","description":"This cluster centers on neural processes: brain development, neurotransmitter secretion, and store-operated calcium channel activation, all pointing to neuronal signaling and calcium-dependent activity. The presence of terms related to TGF-beta signaling, Rac regulation, and ubiquitination suggests broader regulatory modulation that can occur in neural contexts, but the dominant theme remains neural signaling and calcium dynamics.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0071560","count":2},{"id":"GO:1900044","count":2},{"id":"GO:0050798","count":2},{"id":"GO:0032237","count":2}]},{"hash":"1924211626969054021","title":"Developmental cell adhesion and migration","description":"The top GO terms cluster around cell adhesion (heterophilic adhesion, regulation of integrin activation) and cell movement (fibroblast migration, platelet activation), together with developmental events (bone ossification, sympathetic ganglion development, commissural neuron axon guidance). This points to a cohesive theme of adhesion-mediated signaling guiding tissue development and cell migration, despite a few outliers.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0010763","count":3},{"id":"GO:0010572","count":3},{"id":"GO:0006924","count":3}]},{"hash":"1952302270159629954","title":"Vertebrate embryonic organ morphogenesis","description":"The proteins cluster around diverse embryonic development terms across multiple organs (gonad, heart, hindlimb, eye, placenta, habenula), suggesting a shared role in vertebrate organ morphogenesis rather than a tissue-specific pathway. The inclusion of DNA-templated transcription aligns with a broad developmental program.","confidence":"Medium","size":9,"edges":22,"triangles":18,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":8},{"id":"GO:2000288","count":7},{"id":"GO:0021986","count":7},{"id":"GO:0035116","count":7},{"id":"GO:0007507","count":7}]},{"hash":"1636235502181647786","title":"Phytochrome light signaling and circadian rhythm","description":"This cluster centers on light-responsive pathways, especially red/far-red signaling and phototransduction, coupled with circadian rhythm regulation. The presence of GO terms for Rap, Rab, and Rho GTPase signaling and activation of GTPase activity suggests a broader signaling network linked to light-driven regulatory processes and transcriptional control. Some terms like heart development appear as possible noise, but the core theme is phytochrome-mediated light signaling and circadian regulation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0061000","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0010018","count":2}]},{"hash":"26295457808544847","title":"Neural responses to chemical stimuli","description":"The cluster shows strong enrichment for nervous system and sensory-related processes, including responses to cocaine, nicotine, nicotine, ethanol, and insecticides, as well as neuronal signaling features like inhibitory postsynaptic potentials and sodium ion transport. Although a couple terms pertain to reproductive signaling, the dominant theme is neural/sensory processing and chemical cue responsiveness, justifying a neural stimulus\u2013response label.","confidence":"Medium","size":9,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":4},{"id":"GO:0060112","count":4},{"id":"GO:0060080","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0035094","count":4}]},{"hash":"1065588743651723859","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904246","count":1},{"id":"GO:1904628","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0071364","count":1},{"id":"GO:0098789","count":1}]},{"hash":"1892503550718716678","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":2},{"id":"GO:0001935","count":2},{"id":"GO:0010587","count":1},{"id":"GO:0030260","count":1},{"id":"GO:0019076","count":1}]},{"hash":"1745610733664251345","title":"Developmental Adhesion and Synapse Assembly (Neural and Cardiac)","description":"This cluster is dominated by GO terms for cell-cell adhesion, synapse assembly (including neuromuscular junction), and neuronal axon guidance, with additional terms for cardiac/vascular morphogenesis (endocardial cushion migration, dorsal aorta formation). The shared theme appears to be adhesion-mediated tissue morphogenesis and synapse development across neural and cardiac contexts.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0003273","count":5},{"id":"GO:0007416","count":4},{"id":"GO:0048632","count":4},{"id":"GO:0007156","count":4},{"id":"GO:0007157","count":4}]},{"hash":"1830700426745083318","title":"Cardiac conduction and heart development","description":"The top GO terms cluster around heart electrical activity and heart formation, including regulation of SA node action potential, Purkinje myocyte signaling to ventricular cardiac cells, and outflow tract morphogenesis, which together point to cardiac conduction and cardiac development as the main theme. Some terms like skin development or cold response appear less central and may reflect broader developmental roles or annotation noise, but the cardiac-related terms predominate.","confidence":"High","size":9,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0098907","count":5},{"id":"GO:0043588","count":5},{"id":"GO:0007275","count":4},{"id":"GO:1903759","count":4},{"id":"GO:0086029","count":4}]},{"hash":"1508940968091643196","title":"Neural development and synapse assembly","description":"The top GO terms cluster around CNS development, synapse formation, and cell adhesion (both homophilic and heterophilic), with related roles in paranodal and juxtaparanodal axonal organization, interneuron migration, and glutamatergic transmission\u2014pointing to functions in neural development and synapse assembly.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007417","count":2},{"id":"GO:0007416","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0001501","count":2}]},{"hash":"371090263251840980","title":"Neural development and synaptic plasticity","description":"Based on the top GO terms, the cluster centers on neural development (cerebellar cortex development), synaptic signaling (excitatory postsynaptic potential), and plasticity in response to environmental enrichment, supported by transcription-related processes and growth factor signaling. While a few terms touch on other tissues (muscle regeneration, ECM remodeling), the dominant theme is brain development and synaptic adaptability.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046826","count":9},{"id":"GO:0006351","count":9},{"id":"GO:0090648","count":8},{"id":"GO:0021695","count":8},{"id":"GO:0097350","count":8}]},{"hash":"1830580232026764447","title":"TLR-Driven Innate Immunity and Pyroptosis","description":"Top GO terms indicate innate immune defense with Toll-like receptor signaling (TLR4 and TLR8), IL-18 production, and pyroptotic inflammatory responses, plus positive regulation of xenophagy; a plant-related term (meristem regulation) likely reflects annotation noise. Overall, the cluster is best characterized by TLR-mediated innate immune signaling and pyroptosis.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0050830","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0034142","count":3},{"id":"GO:0043086","count":3},{"id":"GO:0070269","count":3}]},{"hash":"1188718953648393617","title":"Developmental cell migration and cytokine signaling","description":"This cluster centers on cell movement (fibroblast and general cell migration; axon fasciculation) in a developmental context (heart development) and includes immune/cytokine signaling responses (GM-CSF, IL-7, TNF), suggesting a cohesive theme of developmentally regulated migration combined with cytokine signaling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010763","count":3},{"id":"GO:0014068","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0097011","count":2}]},{"hash":"1498006220735665453","title":"Mesodermal Development and Notch Signaling","description":"These proteins show a cohesive emphasis on mesoderm formation and early developmental patterning (paraxial and axial mesoderm, somitogenesis, circulatory system development) with a notable link to Notch signaling regulation, a key driver of segmentation and organogenesis. A few terms related to glycolipid metabolism, glycosylation, or rhabdomere development appear less connected, possibly due to annotation breadth or cross-species effects. Overall, the cluster seems to reflect mesodermal development and Notch-mediated patterning.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045747","count":2},{"id":"GO:0006664","count":1},{"id":"GO:0048339","count":1},{"id":"GO:0001756","count":1},{"id":"GO:0048318","count":1}]},{"hash":"228612464474705719","title":"Post-transcriptional RNA processing and translation regulation","description":"Based on GO terms centered on splicing regulation, mRNA export, mRNA stability, polyadenylation, translation initiation, and miRNA-mediated silencing, this cluster appears to group proteins involved in post-transcriptional control of gene expression, particularly RNA processing and translation regulation.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":4},{"id":"GO:0048026","count":3},{"id":"GO:0075525","count":3},{"id":"GO:0035278","count":3},{"id":"GO:0031047","count":3}]},{"hash":"2296862055856896485","title":"Nuclear import/export and RNA trafficking cluster","description":"This cluster is dominated by GO terms for moving macromolecules into and out of the nucleus (ribosomal protein import, NLS-bearing protein import, nuclear pore complex assembly) and exporting RNA species from the nucleus (pre-miRNA export, tRNA re-export). The presence of intraciliary transport and desumoylation regulation terms likely reflects shared transport or regulation processes, but the strongest signal is nuclear-cytoplasmic transport and RNA trafficking.","confidence":"High","size":8,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006610","count":2},{"id":"GO:0060188","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0035735","count":2},{"id":"GO:0051292","count":2}]},{"hash":"1425839415277005941","title":"Unknown","description":"The terms are heterogeneous: virion assembly and uncoating point to viral processes, symbiont entry suggests host-microbe interaction, UV-A response and sepal formation imply stress/development, lipid droplet organization and protein folding are general cellular processes. No clear, common function ties these together, so a single coherent label cannot be assigned. Confidence: None","confidence":"","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":"protein folding","top_go_terms":[{"id":"GO:0034389","count":4},{"id":"GO:0048453","count":4},{"id":"GO:0010849","count":4},{"id":"GO:0030260","count":4},{"id":"GO:0019061","count":4}]},{"hash":"2139589464788842430","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006283","count":4},{"id":"GO:0006260","count":3},{"id":"GO:0000378","count":2},{"id":"GO:0008306","count":2},{"id":"GO:1902775","count":2}]},{"hash":"228905500179137551","title":"Diverse membrane solute transporters","description":"The enrichment of GO terms for transport of various solutes across membranes (nitrate, sugars, ions, xenobiotics) and related processes like neurotransmitter loading suggests these proteins are primarily membrane transporters handling diverse substrates. ","confidence":"High","size":8,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0015751","count":4},{"id":"GO:0097080","count":4},{"id":"GO:0019852","count":4}]},{"hash":"565788532652399647","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":15,"triangles":10,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000466","count":4},{"id":"GO:0000472","count":4},{"id":"GO:0000462","count":4},{"id":"GO:0000480","count":4},{"id":"GO:0042273","count":4}]},{"hash":"682095618844909077","title":"ECM Remodeling and Cell Adhesion in Development","description":"The GO terms cluster around extracellular matrix (ECM) regulation and interactions with cells, including negative regulation of ECM assembly, integrin signaling, calcium-independent cell-matrix adhesion, hyaluronan metabolism, and cell migration, all of which are hallmarks of ECM remodeling and cell-ECM adhesion processes during development (e.g., cartilage morphogenesis). A complement activation term is present but appears less central to the core theme, so the label reflects the dominant pattern of ECM interaction and adhesion in developmental contexts.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1901202","count":2},{"id":"GO:0006956","count":2},{"id":"GO:0003429","count":2},{"id":"GO:0035987","count":2},{"id":"GO:0034113","count":2}]},{"hash":"461866374525980387","title":"Ribosome biogenesis and translation","description":"This cluster is dominated by GO terms for translation and ribosome biogenesis (including small subunit biogenesis/assembly) and nucleolus organization, pointing to ribosome production and protein synthesis as the core function. A couple of outliers relate to immune signaling, but are minor.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0042254","count":3},{"id":"GO:0042274","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0007049","count":2}]},{"hash":"2011277366555833594","title":"ER-Golgi trafficking and cell cycle during development","description":"Proteins here show strong signals for secretory pathway transport between the ER and Golgi (COPII budding and retrograde transport) alongside core cell cycle processes (mitotic spindle assembly, cell division). The inclusion of development-related terms (brain development, multicellular organism growth) suggests this module connects vesicle trafficking with proliferative growth during development, making them a coherent group centered on ER-Golgi trafficking linked to cell division and growth.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0006890","count":2}]},{"hash":"95101764403690147","title":"Unknown","description":"The top GO terms are diverse, spanning cellular response to ATP, nitric oxide production, TGF-beta signaling, ncRNA-mediated gene silencing, response to cocaine, protein localization to the cell surface, translational attenuation, protein binding, and virion attachment to host cells. There isn\u2019t a single cohesive biological process tying these together, so a clear, representative label isn\u2019t apparent.","confidence":"","size":8,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071318","count":3},{"id":"GO:0045429","count":3},{"id":"GO:0030511","count":3},{"id":"GO:0031047","count":2},{"id":"GO:0042220","count":2}]},{"hash":"1014187983821837711","title":"Developmental gene expression and RNA processing","description":"Top GO terms point to developmental processes (embryonic cranial skeleton morphogenesis, antennal development) alongside core gene expression machinery (DNA-templated transcription, RNA splicing/exon ligation, and mRNA decay pathways). The presence of stress granule localization and mitochondrial ribosome assembly hints at broader RNA metabolism and translation readiness in developing cells. Taken together, the cluster appears to be involved in regulating gene expression during development, through transcription and RNA processing.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":2},{"id":"GO:0007469","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000378","count":1},{"id":"GO:0008306","count":1}]},{"hash":"1867202392272206183","title":"Embryonic organogenesis and tissue development","description":"This cluster is enriched for multiple embryonic development and morphogenesis terms across diverse organs (heart tube formation, pulmonary valve morphogenesis, bronchiole and mesenchyme development, oculomotor nerve and inner ear differentiation, pigmentation, and neural fate commitment). This suggests a shared role in developmental patterning and organ formation, despite some more general terms like transcription and DNA repair appearing among the top terms.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006302","count":5},{"id":"GO:0006366","count":5},{"id":"GO:0003184","count":5},{"id":"GO:0060435","count":4},{"id":"GO:0060485","count":4}]},{"hash":"1612381373194523274","title":"Fungal lipid and sterol biosynthesis","description":"The strongest signal in this cluster comes from lipid and sterol metabolism terms: unsaturated fatty acid biosynthesis, a sphingolipid (MIPC) metabolic process, and ergosterol biosynthetic regulation, which are characteristic of fungal membrane lipid pathways. Other terms (nitrate assimilation, nitric oxide biosynthesis) are more general and may reflect broader metabolism or annotation noise, while some terms are unrelated to fungi (e.g., myelin maintenance, sebaceous gland differentiation). Overall, the cluster is best described as involving fungal lipid and sterol biosynthesis.","confidence":"Medium","size":8,"edges":25,"triangles":40,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006636","count":3},{"id":"GO:0042128","count":3},{"id":"GO:0006675","count":3},{"id":"GO:0032286","count":3},{"id":"GO:0006809","count":3}]},{"hash":"304092094988789208","title":"Muscle development and NMJ actin dynamics","description":"The cluster\u2019s GO terms mainly point to skeletal muscle fiber development and actin cytoskeleton regulation at the neuromuscular junction, including actin polymerization, actin filament bundle assembly, subsynaptic reticulum organization, and NMJ assembly regulation. This supports a cohesive theme of muscle morphogenesis and NMJ maintenance driven by actin dynamics, with a single outlier term (behavioral response to cocaine) likely representing noise rather than core function.","confidence":"High","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048148","count":2},{"id":"GO:1902404","count":1},{"id":"GO:1990255","count":1},{"id":"GO:0048741","count":1},{"id":"GO:0032233","count":1}]},{"hash":"547752558852310911","title":"Nuclear RNA Export and Protein Import","description":"The top GO terms cluster around nucleocytoplasmic transport: mRNA export, tRNA re-export, pre-miRNA export, and ribosomal protein import, suggesting a shared role in trafficking RNA/protein complexes across the nuclear envelope; while a few terms relate to lipid biosynthesis and desumoylation regulation, the dominant signal is RNA and ribonucleoprotein transport.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0009826","count":2},{"id":"GO:0006656","count":1},{"id":"GO:0035281","count":1}]},{"hash":"658211208193028912","title":"Ubiquitin-mediated mitophagy and mitochondrial dynamics","description":"The terms point to a mitochondria-centered quality-control role: protein deubiquitination, mitophagy, and regulation of mitochondrial fusion, plus broader autophagy-related control. While some terms (insecticide response, rRNA maturation) are less directly connected, the core theme is ubiquitin signaling governing mitochondrial turnover and autophagy.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":8},{"id":"GO:1901340","count":6},{"id":"GO:0002109","count":6},{"id":"GO:0010636","count":6},{"id":"GO:0000423","count":6}]},{"hash":"1920389016689273955","title":"ER Stress and Unfolded Protein Response","description":"The top terms are clearly centered on ER stress and unfolded protein response, notably positive regulation of translation initiation in response to ER stress and response to unfolded protein, indicating a core role in protein-folding stress management. Some terms (dsRNA response, snoRNP assembly, and obsolete annotations) may reflect ancillary or historical associations, but the dominant theme supports an ER stress/UPR function.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0036494","count":8},{"id":"GO:0006986","count":8},{"id":"GO:0071360","count":7},{"id":"GO:1903646","count":7},{"id":"GO:0000492","count":7}]},{"hash":"1832628226094695660","title":"Ribosome Biogenesis and Cell Cycle","description":"The cluster is dominated by terms for cell division/cell cycle and ribosome biogenesis (including ribosomal subunit biogenesis and tRNA modification), pointing to growth and protein-synthesis machinery as the core function. Peripheral terms related to DNA integration and viral/host interactions appear as outliers and do not define the main theme.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0042254","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3}]},{"hash":"260442666259181802","title":"Embryonic organogenesis and tissue differentiation","description":"The top GO terms indicate multiple organ-development processes (bronchiole development, heart tube formation, oculomotor nerve development, inner ear differentiation, mesenchyme and neural development) along with pigmentation and transcriptional regulation. This pattern points to proteins involved in broad embryonic development and differentiation across tissues rather than a single specific function. Confidence in this label is Medium.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0060435","count":7},{"id":"GO:0060485","count":7},{"id":"GO:0060163","count":7},{"id":"GO:0043473","count":7}]},{"hash":"957818438228535065","title":"Cerebellar development and synaptic plasticity regulation","description":"Dominant terms point to cerebellar development and synaptic signaling, including cerebellar cortex development, excitatory postsynaptic potential, and regulation of synaptic plasticity, with supporting signals from environmental enrichment and growth factor responses and ECM remodeling, suggesting neural development and synaptic regulation as the cluster theme. Some terms are peripheral (neutrophil clearance, diadenosine tetraphosphate biosynthesis) but do not override the neural core.","confidence":"Medium","size":8,"edges":22,"triangles":31,"max_degree":7,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0090648","count":8},{"id":"GO:0021695","count":8},{"id":"GO:0097350","count":8},{"id":"GO:0060079","count":8},{"id":"GO:0090188","count":8}]},{"hash":"1052639914079159134","title":"Neuronal Development and Synaptic Plasticity","description":"Top terms indicate long-term synaptic potentiation, excitatory postsynaptic potential, axonogenesis, Schwann cell development, and multicellular development, pointing to neural development and synaptic maturation; some terms (G2/M transition, abscisic acid signaling, heart development) may reflect broader annotation or multifunctionality, but the dominant theme is neural development and synaptic plasticity.","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060291","count":7},{"id":"GO:0060079","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0007409","count":7},{"id":"GO:0043065","count":7}]},{"hash":"1198013263625238702","title":"GTPase Signaling and Actin Remodeling","description":"The top GO terms center on positive regulation of GTPase activity and regulation of kinase signaling, alongside Arp2/3-mediated actin nucleation, suggesting a coordinated program of signal transduction and cytoskeletal remodeling. Additional themes like mitotic cell cycle, mRNA transport, and responses to hypoxia or metal stress point to broader regulatory roles that connect signaling with cell division and gene expression, rather than a single linear pathway. Because the cluster reflects a set of related regulatory processes rather than a tightly linked molecular complex, a label emphasizing signaling and cytoskeletal dynamics best captures the shared function.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0031954","count":5},{"id":"GO:0071456","count":5},{"id":"GO:0071902","count":5}]},{"hash":"1387851859952467834","title":"Kinase Activity Regulation","description":"The strongest terms are negative regulation of protein kinase activity and protein phosphorylation, pointing to a shared theme of modulating kinase signaling. Although other terms appear (some obsolete or broader), the recurring phosphorylation-related processes suggest these proteins function in regulating kinase activity rather than a single non-kinase role.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":4},{"id":"GO:0006468","count":4},{"id":"GO:0097274","count":4},{"id":"GO:0043950","count":3},{"id":"GO:0010459","count":3}]},{"hash":"594466956751898388","title":"Cardiac Growth and Angiogenesis Signaling","description":"The prevalent terms center on heart development and positive regulation of cardiac hypertrophy in response to stress, along with angiogenesis and VEGF signaling. Additional GO terms highlight general signaling processes (protein phosphorylation, GTPase activity, cAMP signaling) that couple growth with vascular remodeling. A peripheral nervous system myelination term appears incidental or reflects shared signaling pathways rather than a neural-specific role, but overall the cluster maps to cardiovascular growth and signaling.","confidence":"Medium","size":8,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903244","count":5},{"id":"GO:0043950","count":4},{"id":"GO:0030948","count":4},{"id":"GO:0022011","count":4},{"id":"GO:0008284","count":4}]},{"hash":"922493375438399327","title":"Unknown","description":"This cluster includes a mix of terms spanning calcium signaling, neural activity, muscle-related processes, temperature and metabolic responses, skin development, and digestive regulation, with no single cohesive GO biology theme. Because there is no strong shared function binding the top terms, a concise, representative label cannot be assigned beyond Unknown.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051209","count":3},{"id":"GO:0071502","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0002024","count":3},{"id":"GO:0019233","count":3}]},{"hash":"501972072153154061","title":"Neuronal adhesion and axon domain organization","description":"These proteins show strong signals for neuronal connectivity: cell\u2013cell adhesion (homophilic/heterophilic), paranodal junction assembly, juxtaparanode localization, and positive regulation of synapse assembly, plus interneuron migration cues. While one term relates to skeletal development, the predominant theme is axon domain organization and synapse formation in the nervous system, suggesting adhesive and axonal targeting roles.","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0007156","count":4},{"id":"GO:0007157","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0021836","count":4}]},{"hash":"1138531347038391361","title":"Ubiquitin-Driven Immune Signaling and Cytoskeletal Dynamics","description":"Proteins in this cluster are enriched for ubiquitination processes (protein and actin ubiquitination) and immune signaling functions (T cell receptor signaling, V(D)J recombination, NF-kappaB regulation), with additional links to cytoskeletal components (microtubule localization, actin dynamics). This pattern points to a coherent theme of ubiquitin-mediated regulation of immune pathways coupled to cytoskeletal organization.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":3},{"id":"GO:0016567","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0035556","count":2},{"id":"GO:0000185","count":2}]},{"hash":"1680361406012449080","title":"cAMP Signaling and DNA Metabolism","description":"The presence of GO:0071320 (cellular response to cAMP) and GO:0046856 (phosphatidylinositol dephosphorylation) points to signaling pathways, while GO:0006308 (DNA catabolic process) and GO:0006310 (DNA recombination) indicate DNA metabolism. Other terms are obsolete or relate to xenobiotic response or skin development, suggesting broader or less coherent annotations. Therefore the cluster is best described as \u201ccAMP signaling and DNA metabolism\u201d with moderate confidence.","confidence":"Medium","size":8,"edges":9,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071320","count":2},{"id":"GO:0006308","count":1},{"id":"GO:0042493","count":1},{"id":"GO:0090502","count":1},{"id":"GO:0003335","count":1}]},{"hash":"1309967924711445146","title":"Monoaminergic Neuromodulation and Behavior","description":"The top GO terms cluster around monoaminergic neurotransmission (octopamine signaling pathway; norepinephrine biosynthesis) and behavioral phenotypes (mating behavior, locomotory behavior, behavioral response to ethanol, sex discrimination). This suggests proteins in the cluster participate in neuromodulation that shapes behavior, with a few outlier terms likely noise or misannotation (immune-related and obsolete cuticle biosynthesis). Confidence: Medium.","confidence":"","size":8,"edges":11,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048047","count":1},{"id":"GO:0045907","count":1},{"id":"GO:1900449","count":1},{"id":"GO:0006035","count":1},{"id":"GO:0071927","count":1}]},{"hash":"1709189994408588263","title":"Neurodevelopment and tissue morphogenesis","description":"The top GO terms center on neural development\u2014synapse assembly, axon guidance, and pain perception\u2014as well as broad morphogenesis processes such as angiogenesis, skeletal development, and organ morphogenesis, indicating a cluster of proteins involved in shaping neural connectivity and tissue development.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0007156","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0001501","count":3}]},{"hash":"898274941118885871","title":"Neuronal endocytosis and synaptic signaling","description":"The top GO terms cluster around endocytosis, actin filament remodeling, and Rap-mediated signaling, with brain development and excitatory postsynaptic potential suggesting roles in synaptic vesicle trafficking and neuronal communication. Some terms (hair follicle morphogenesis, negative chemotaxis) are less directly connected, but the dominant signal points to neuronal endocytosis and synaptic signaling.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006897","count":6},{"id":"GO:0034260","count":6},{"id":"GO:0031069","count":5},{"id":"GO:0050919","count":5},{"id":"GO:0090316","count":5}]},{"hash":"909131532609187907","title":"Steroid hormone and sphingolipid metabolism","description":"This cluster is dominated by GO terms for steroid biosynthesis (estrogen, testosterone) and androgen/steroid catabolic processes, along with sphingolipid biosynthesis, pointing to a lipid/steroid metabolic theme. Other terms like lung development or antibiotic response appear less central to the core theme, so the primary signal is lipid and steroid metabolism.","confidence":"High","size":8,"edges":5,"triangles":1,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0046677","count":5},{"id":"GO:0006703","count":4},{"id":"GO:0006666","count":4},{"id":"GO:0061370","count":4}]},{"hash":"1627023399138993497","title":"Transposon and Proviral Integration","description":"The top GO terms cluster around DNA transposition, retrotransposition, DNA integration, and proviral latency, plus viral entry into the host nucleus, which together point to transposable elements and retroviral/proviral activities as the shared function of this cluster. Some terms may reflect general host\u2013pathogen interaction context or background cellular processes, but the dominant signal is transposon/retroelement activity.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0032197","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0039651","count":2}]},{"hash":"559067985469681975","title":"Unknown","description":"The top GO terms are highly heterogeneous, including obsolete aging, cellular responses to ATP and cAMP, xenobiotic response, DNA and RNA metabolism, corneocyte development, and a neural migration term. This mix shows no clear, unifying biological function or pathway connecting the proteins, and several terms are obsolete. Therefore there isn\u2019t a coherent theme to name the cluster, so it is labeled Unknown with None confidence.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":2},{"id":"GO:0071318","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0022028","count":2},{"id":"GO:0006308","count":1}]},{"hash":"1461679715563564266","title":"Ion transport and membrane potential regulation","description":"The GO terms center on ion handling (potassium, calcium, manganese) and membrane potential dynamics (resting potential regulation, stabilization, repolarization), including atrial myocyte-specific repolarization. This points to a cohesive role in ion transport and electrical excitability, likely involving ion channels or transporters that can oligomerize. Some sensory-related terms may reflect broader excitability but are less central to the main theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030007","count":2},{"id":"GO:0071502","count":2},{"id":"GO:0050976","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0098914","count":2}]},{"hash":"2171488522153144493","title":"Chloroplast photosynthesis and stress-response proteins","description":"This cluster features GO terms for photosynthesis and cadmium ion response, plus protein heterooligomerization, suggesting components of chloroplast photosynthetic machinery that assemble into multi-subunit complexes and participate in stress responses (including metal stress). The presence of several obsolete terms likely reflects legacy annotations tied to regulation of protein folding and modification, but the core signal points to chloroplast-associated photosynthetic function with stress-related roles.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051291","count":6},{"id":"GO:0071360","count":5},{"id":"GO:1903646","count":5},{"id":"GO:0051348","count":5},{"id":"GO:1902391","count":5}]},{"hash":"2014303609929183971","title":"Lipid and sterol biosynthesis","description":"This cluster shows enrichment mainly in lipid-related biosynthetic processes: ether lipid biosynthesis, sterol biosynthesis, wax biosynthesis, and related secondary alcohol biosynthesis, with supporting hints from UDP-D-xylose biosynthesis (a sugar donor linked to glycosylation of lipids and polysaccharides). Some GO terms are obsolete, which may reflect annotation noise, but the central theme is lipid/sterol metabolism.","confidence":"High","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0019835","count":3},{"id":"GO:0043046","count":3},{"id":"GO:0008611","count":2},{"id":"GO:0016126","count":2}]},{"hash":"2168704996758027933","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":2},{"id":"GO:0002938","count":1},{"id":"GO:0000453","count":1},{"id":"GO:0097190","count":1},{"id":"GO:0002509","count":1}]},{"hash":"736162449959443462","title":"Actin Cytoskeleton Assembly and Organization","description":"Reason: The top GO terms are dominated by actin-related processes\u2014actin filament formation, polymerization, cortical actin organization, and nucleation\u2014indicating proteins involved in actin assembly and cytoskeletal organization. Some secondary terms involve microtubule localization and cell cycle-related events, but the core signal is actin dynamics. ","confidence":"High","size":8,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051639","count":2},{"id":"GO:0030041","count":2},{"id":"GO:0030866","count":2},{"id":"GO:0035372","count":2},{"id":"GO:0090140","count":2}]},{"hash":"1976531574979107126","title":"Neuronal vesicle transport and spine development","description":"This cluster is dominated by GO terms for ER-Golgi vesicle transport and positive regulation of dendritic spine development, paired with small GTPase-mediated signaling, pointing to proteins involved in neuronal vesicle trafficking and regulation of synaptic structures. Brain development and ion homeostasis terms further suggest a neural context, though the strongest, most cohesive signal is vesicle trafficking linked to neuronal growth and spine formation.","confidence":"Medium","size":8,"edges":9,"triangles":1,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0006623","count":4},{"id":"GO:0007049","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0060999","count":4}]},{"hash":"542137543158304628","title":"Lipid Biosynthesis and Adipogenesis","description":"The shared functions center on sphingolipid and fatty acid biosynthesis (sphinganine and sphingosine metabolic processes, monounsaturated fatty acid biosynthesis) and cholesterol esterification, plus white fat cell differentiation, pointing to lipid metabolism and adipogenesis as the core theme of the cluster. Some terms are obsolete or less specific (photoinhibition, water loss regulation), but the dominant signal is lipid production and adipocyte development.","confidence":"High","size":8,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":4},{"id":"GO:0046512","count":4},{"id":"GO:0034435","count":4},{"id":"GO:1903966","count":4},{"id":"GO:1903699","count":4}]},{"hash":"1942458509588722033","title":"Plant stress and immune signaling","description":"The proteins show enriched terms for innate immune response and cellular response to exogenous dsRNA, indicating antiviral defense. Additional terms like cellular responses to cadmium and photosynthesis point to plant-specific stress and energy management, with cell division suggesting growth regulation. This pattern best fits a plant-wide stress/defense program rather than a single enzymatic function.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0045087","count":4},{"id":"GO:0071360","count":3},{"id":"GO:1903646","count":3},{"id":"GO:0051348","count":3}]},{"hash":"1101012969678533630","title":"Unknown","description":"The GO terms are highly diverse (infection structure formation, glycosylation, various developmental processes, meiosis, polarity maintenance) with no dominant shared pathway or function, and the cluster has no connecting edges, so a single representative label is not justifiable.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":2},{"id":"GO:0007386","count":1},{"id":"GO:0010493","count":1},{"id":"GO:0032092","count":1},{"id":"GO:0055016","count":1}]},{"hash":"184633566119843097","title":"Carbohydrate metabolism and glycosylation biosynthesis","description":"The top terms cluster around sugar-related biosynthetic and metabolic processes (starch, glycogen, sucrose) and glycosylation pathways (GPI anchor biosynthesis, protein glycosylation), with additional osmotic and stress-response associations (response to sorbitol/sucrose). Although there are no edges linking the proteins, the recurring theme is carbohydrate metabolism and glycosylation machinery, suggesting a cohesive functional group rather than disparate processes.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0072708","count":2},{"id":"GO:0019252","count":2},{"id":"GO:0005985","count":2},{"id":"GO:0097502","count":2}]},{"hash":"2250685647333009793","title":"Viral Entry and Proviral Integration","description":"This cluster\u2019s top GO terms center on proviral latency establishment, DNA integration, and viral penetration into the host nucleus, pointing to functions involved in viral infection and integration of viral DNA into the host genome. A few unrelated terms (e.g., glycosylation, plant cell wall processes) may reflect annotation noise rather than core function. Overall, the theme is viral entry and proviral DNA integration into host cells.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0046718","count":2}]},{"hash":"536095530475144363","title":"DNA Replication and Genome Integration","description":"The top GO terms are dominated by DNA-associated processes, notably DNA integration and DNA replication, which suggests a core function in genome metabolism and integration events. Several other terms point to developmental or cellular processes but have much lower representation and are likely incidental. Given the strongest signal from DNA-related terms, the cluster name centers on DNA replication/integration.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0006486","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0006049","count":1},{"id":"GO:0035010","count":1}]},{"hash":"1333605991906158271","title":"Neuronal development and intracellular transport","description":"The cluster is marked by neural development signals (brain development; excitatory postsynaptic potential) alongside intracellular trafficking and cytoskeletal remodeling (endosome to melanosome transport; positive regulation of intracellular protein transport; actin filament branching). Rap signaling and nucleolus localization suggest coordinated signaling and transport activities during development, with some hints of pigmentation-related processes (hair follicle morphogenesis). Confidence: Medium","confidence":"","size":8,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1902570","count":3},{"id":"GO:0035646","count":3},{"id":"GO:0031069","count":2},{"id":"GO:0050919","count":2},{"id":"GO:0090316","count":2}]},{"hash":"75664026089008989","title":"Wnt Secretion and ER-Golgi Trafficking","description":"The terms point to the secretory pathway: ER retention, COPI-coated Golgi vesicles, extrusion of proteins from the ER, and Golgi ribbon formation, combined with positive regulation of Wnt protein secretion. This suggests a cohesive theme around how proteins are trafficked through the ER-Golgi system to enable Wnt signaling, which is a key developmental pathway. Some development-related terms (placenta, axis specification) may reflect contexts in which these secretory processes operate, or dataset noise, but the core signal centers on secretion and Wnt regulation.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006621","count":1},{"id":"GO:0001893","count":1},{"id":"GO:0032525","count":1},{"id":"GO:0007311","count":1},{"id":"GO:0048205","count":1}]},{"hash":"436582324957532107","title":"Cell Cycle and Division Regulators","description":"The dominant GO terms point to core cell-cycle and mitotic processes (cell cycle, cell division, spindle assembly) with involvement of ubiquitin-dependent degradation via the multivesicular body pathway, and apoptosis related to cell-cycle checkpoints. These together suggest a theme of cell-cycle control and mitotic regulation, with linked protein turnover, rather than unrelated functions.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0043162","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0000920","count":2}]},{"hash":"2076554235677827813","title":"Neuropeptide and Autonomic Stress Signaling","description":"The cluster centers on neuropeptide signaling (GO:0007218) and related autonomic control components, including dopamine uptake regulation (GO:0051586) and vasopressin-mediated blood pressure modulation (GO:0001992). It also highlights autonomic/physiological responses to temperature and metabolic cues (GO:0071502, GO:0002024) and muscle relaxation (GO:0090075), with ancillary links to inflammatory regulation (GO:0032651). Taken together, these terms point to a cohesive role in neuroendocrine and autonomic regulation of stress responses, cardiovascular tone, and energy balance, with some immune signaling cross-talk. ","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0019233","count":6},{"id":"GO:0043950","count":5},{"id":"GO:0032651","count":5}]},{"hash":"181185963318388891","title":"Neural axon guidance and development signaling","description":"The cluster shows enrichment for neuronal projection guidance (ROBO/SLIT), Hedgehog (SMO) and BMP signaling, and cell adhesion, all converging on neural development and axon guidance; muscle-related term may reflect neuromuscular development but does not override the dominant neural guidance theme.","confidence":"High","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097350","count":2},{"id":"GO:0030513","count":2},{"id":"GO:0007224","count":2},{"id":"GO:1901214","count":2},{"id":"GO:0007156","count":2}]},{"hash":"261799286255178455","title":"Viral DNA Integration and Proviral Latency","description":"These proteins cluster around viral DNA lifecycle activities: DNA recombination and replication, DNA integration, RNA-templated DNA synthesis, and the establishment of integrated proviral latency, plus viral entry into the host nucleus. The combination of integration, latency, and entry points to a viral infection/latency program as the shared theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006310","count":2},{"id":"GO:0006278","count":1},{"id":"GO:1903704","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0015074","count":1}]},{"hash":"1002070067196666660","title":"Developmental and Immune Cell Migration","description":"The cluster centers on developmental processes across heart and neuron lineages, hematopoiesis, and differentiation of NK T cells, along with cell migration and cytokine-responsive signaling (GM-CSF, IL-7). Together these terms suggest a theme of developmentally regulated cell movement within immune and other vertebrate lineages, with additional signaling and apoptosis regulation that can accompany differentiation and migration.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0016477","count":6},{"id":"GO:0097011","count":6},{"id":"GO:0046329","count":6},{"id":"GO:0097194","count":6}]},{"hash":"143334381540664315","title":"Cardiac morphogenesis and neural development","description":"This cluster\u2019s GO terms cluster around developmental processes, especially heart development (ventricular cardiac muscle cell development, mesoderm formation, and proliferation) and neural tube formation, with supportive hints from lung morphogenesis and neuronal signaling. While there\u2019s a clear focus on developmental programs, some terms (like ER unfolded protein response) add broader cellular stress context, so the theme is developmental with an emphasis on cardiac and neural tissue morphogenesis rather than a single, tightly defined pathway.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:0001707","count":2},{"id":"GO:0060045","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0055015","count":2}]},{"hash":"1588597494923815890","title":"Retroviral integration and transposition","description":"The terms point to mobile genetic elements and viral integration processes: DNA integration, retrotransposition, DNA transposition, and establishment of integrated proviral latency, plus RNA-templated DNA biosynthesis and viral entry into the host nucleus. Together these suggest a coherent theme of transposable elements and proviral activities rather than a single, non-overlapping function. Some ancillary terms about symbiont interactions and RNAi regulation appear, but the dominant signal centers on integration and transposition.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0046718","count":3}]},{"hash":"569473144622520174","title":"Immune activation and kidney development","description":"The cluster shows enrichment for innate immune processes (cellular response to fungal origin, complement activation lectin pathway, phagocytosis recognition, basophil activation, platelet activation, arachidonate signaling) alongside kidney organogenesis terms (mesonephric duct development, metanephric proximal/distal tubule morphogenesis). While these are distinct areas, their co-occurrence suggests a theme of inflammation-related signaling intersecting with nephrogenesis, rather than a single narrow function.","confidence":"Medium","size":8,"edges":6,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":8},{"id":"GO:0090238","count":6},{"id":"GO:0001502","count":6},{"id":"GO:0006910","count":6},{"id":"GO:0001867","count":6}]},{"hash":"1867188884671093248","title":"Adhesion-driven tissue morphogenesis","description":"The cluster shows a core of GO terms centered on cell adhesion (substrate, cell-cell, matrix) and lamellipodium morphogenesis, with specific links to osteoblast development and biomineral tissue development. This points to a shared role in adhesion-mediated cell migration and tissue morphogenesis, particularly in bone-related contexts, even though a few terms are less directly connected. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010811","count":1},{"id":"GO:0090305","count":1},{"id":"GO:0002076","count":1},{"id":"GO:0007156","count":1},{"id":"GO:0061302","count":1}]},{"hash":"263199269900137087","title":"Viral DNA integration and proviral latency","description":"This cluster is driven by GO terms for DNA integration, reverse transcription, DNA recombination, retrotransposition, and proviral latency, including viral entry into the host nucleus. Although a couple of symbiont-associated terms appear, the dominant signal is retroviral/proviral DNA integration and latency.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0006278","count":1},{"id":"GO:1903704","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0006310","count":1}]},{"hash":"563937221787099750","title":"Viral integration and retrotransposon activity","description":"The cluster is dominated by GO terms related to genome integration and mobility, including proviral latency establishment, DNA integration, DNA transposition, and retrotransposition, as well as viral penetration into the host nucleus and symbiont entry into host cells. This suggests a cohesive theme around infection-associated integration and transposable element activity, encompassing both viral and transposon-related processes that move genetic material within or into the host genome. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":7},{"id":"GO:0015074","count":7},{"id":"GO:0032197","count":7},{"id":"GO:0075732","count":7},{"id":"GO:0039651","count":7}]},{"hash":"2250659973670068276","title":"Mitotic spindle assembly and MT organization","description":"The top GO terms cluster around microtubule organization and spindle-related processes: mitotic spindle assembly, centrosome duplication, microtubule nucleation, cortical and astral MT anchoring, and meiotic spindle components. This points to a cohesive function in assembling and organizing the microtubule cytoskeleton during cell division and maintaining cell polarity. The cluster thus seems to represent proteins coordinating spindle assembly and MT dynamics across mitosis and meiosis.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051415","count":1},{"id":"GO:0030472","count":1},{"id":"GO:0051298","count":1},{"id":"GO:0071963","count":1},{"id":"GO:1990734","count":1}]},{"hash":"66255565025896888","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":5},{"id":"GO:0006378","count":4},{"id":"GO:1901407","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0051301","count":3}]},{"hash":"272301406578036426","title":"Cell division and organelle dynamics","description":"The cluster shows enrichment in cell cycle-related terms (cell division, centriole elongation) alongside processes tied to RNA processing, transcription elongation, mitochondrial protein import, chaperone-mediated assembly, and autophagosome maturation, indicating coordination between cell division and organelle biogenesis/maintenance. Confidence in this thematic label is Medium.","confidence":"","size":7,"edges":17,"triangles":19,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1904874","count":3},{"id":"GO:0045041","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0051131","count":3},{"id":"GO:1903724","count":2}]},{"hash":"1931918271625273121","title":"RNA processing and stress-responsive gene regulation","description":"Enriched with spliceosome-mediated mRNA splicing, regulation of mRNA stability under stress, ncRNA-mediated silencing, miRNA turnover, and ribosome biogenesis, indicating a core theme of RNA metabolism linked to stress responses.","confidence":"High","size":7,"edges":11,"triangles":10,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0010610","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0009432","count":3}]},{"hash":"512340864155153975","title":"Translation initiation and ribosome biogenesis","description":"The top terms cluster around translation machinery (preinitiation complex formation, translation reinitiation, EIF4F assembly) and ribosome biogenesis, indicating a module focused on assembling ribosomes and initiating translation; additional terms on mRNA export and RNA silencing appear ancillary to this main function.","confidence":"High","size":7,"edges":12,"triangles":8,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0048026","count":1},{"id":"GO:0075525","count":1}]},{"hash":"1426169608426004627","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0009432","count":2}]},{"hash":"504307793590446344","title":"Nuclear RNA Processing and Transcription Regulation","description":"The cluster is dominated by GO terms for nuclear RNA maturation and transcription control\u2014mRNA processing, splicing, decapping, and termination of RNA Pol II\u2014plus import into the nucleus and histone mRNA metabolism, indicating a cohesive nuclear RNA-processing theme, with some stress-response termsSupplementary: stress-related terms appear but the main signal is RNA processing/transcription in the nucleus.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0000290","count":7},{"id":"GO:0008033","count":7},{"id":"GO:0008334","count":7},{"id":"GO:0009414","count":7},{"id":"GO:0051170","count":7}]},{"hash":"1187313958418678584","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000466","count":3},{"id":"GO:0048568","count":3},{"id":"GO:0000472","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0000480","count":3}]},{"hash":"1457126953517928012","title":"Dendritic cell\u2013mediated antigen presentation and phagocytosis","description":"The terms show clear immune-related roles: peptide antigen assembly with MHC I, innate immune signaling, dendritic cell chemotaxis, and positive regulation of phagocytosis, suggesting the cluster centers on dendritic cell\u2013driven antigen processing and immune activation. Some terms (ossification, sperm binding, hormone signaling) are less directly related, possibly reflecting multifunctional proteins or annotation overlap. ","confidence":"Medium","size":7,"edges":13,"triangles":11,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0033144","count":3},{"id":"GO:1900026","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0071157","count":2},{"id":"GO:0002502","count":2}]},{"hash":"1787472161267094550","title":"ROBO signaling-driven neuronal development and actin remodeling","description":"This cluster is dominated by neuronal development and signaling terms: Roundabout signaling pathway (ROBO), brain development, excitatory postsynaptic potential, and actin filament branching, pointing to axon guidance and synaptic maturation with cytoskeletal remodeling. Rap signaling also connects to neuronal signaling pathways. Some terms reflect broader developmental or stress responses (e.g., hair follicle morphogenesis, xenobiotic stimulus), but the strongest signal centers on ROBO-mediated neural development and cytoskeletal dynamics.","confidence":"High","size":7,"edges":15,"triangles":13,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031069","count":6},{"id":"GO:0050919","count":6},{"id":"GO:0090316","count":6},{"id":"GO:0090135","count":6},{"id":"GO:0032486","count":6}]},{"hash":"1228895076757179045","title":"RNA Processing and Chromatin Regulation","description":"This cluster centers on RNA metabolism and regulation (ncRNA silencing, spliceosome-mediated splicing, rRNA and tRNA processing, mitochondrial ribosome assembly) with links to chromatin regulation (rDNA heterochromatin formation). While a few terms touch on cell cycle, differentiation, and behavior, the strongest shared theme is RNA processing coupled with chromatin dynamics.","confidence":"Medium","size":7,"edges":4,"triangles":0,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0051726","count":2},{"id":"GO:0000183","count":2},{"id":"GO:1902775","count":2}]},{"hash":"2154897081681780987","title":"RNA processing and translational control","description":"The top GO terms cluster around post-transcriptional gene regulation, including mRNA splicing regulation, mRNA export, poly(A) tail regulation, translation elongation/termination control, and RNA silencing (miRNA/ncRNA\u2013mediated). The oskar mRNA localization term further supports RNA localization as part of regulation. Together, these indicate a functional group centered on RNA metabolism and control of translation rather than transcription initiation.","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":2},{"id":"GO:0045451","count":1},{"id":"GO:0048026","count":1},{"id":"GO:0075525","count":1},{"id":"GO:0035278","count":1}]},{"hash":"2097935677265168881","title":"COPII-coated ER\u2013Golgi vesicle trafficking","description":"This cluster is enriched for ER\u2013Golgi vesicle transport terms, including COPII-coated vesicle budding and Golgi-to-ER retrograde transport, indicating a core role in the secretory pathway. Additional terms touching on stress response, brain development, and proliferation appear but are likely secondary associations to the central trafficking function.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0006890","count":3},{"id":"GO:0035900","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0090114","count":2}]},{"hash":"779894469143627697","title":"Unknown","description":"The GO terms span very different processes (lipoylation and amino acid metabolism, glycine cleavage, fructosamine metabolism, transcription elongation regulation, mitotic spindle elongation, phosphorylation, and antibiotic response), with no clear shared pathway or function among the proteins. There is minimal connectivity and no coherent theme to anchor a specific label, so Unknown with low confidence.","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009249","count":1},{"id":"GO:0019464","count":1},{"id":"GO:0030389","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0019509","count":1}]},{"hash":"1784094896206795704","title":"Unknown","description":"No GO terms or connections are reported for this cluster (Top Terms is empty and there are zero edges/triangles), so there is no clear shared function to assign a label.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1348483436577648802","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006295","count":3},{"id":"GO:0090267","count":2},{"id":"GO:0001302","count":2},{"id":"GO:0071140","count":2},{"id":"GO:0045190","count":2}]},{"hash":"1379521674744297765","title":"Neuronal axon guidance and synapse formation","description":"The top terms strongly point to neural development, especially Slit-Robo (Roundabout) signaling guiding axons across the midline, plus regulation of GTPase activity, axon guidance for commissural and retinal ganglion cells, and processes promoting synapse assembly and synaptic vesicle endocytosis. The presence of inflammatory and apoptotic-cell engulfment terms suggests microglial involvement in pruning and remodeling during neural development, which complements the axon guidance and synapse formation theme. While a couple terms (e.g., ossification) are less directly related, the core signal centers on neuronal connectivity and synapse maturation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035385","count":3},{"id":"GO:0034260","count":2},{"id":"GO:0008283","count":2},{"id":"GO:1900242","count":2},{"id":"GO:0006954","count":2}]},{"hash":"161232092030951075","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0009718","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0042619","count":2}]},{"hash":"463347997731431592","title":"tRNA aminoacylation and wobble modification (mitochondrial)","description":"The top GO terms cluster around charging tRNAs (lysyl-, mitochondrial asparaginyl/aspartyl-tRNA), and tRNA wobble cytosine modification, which together point to tRNA biology and translation-related processing, including both cytosolic and mitochondrial contexts. Some terms (like lipopolysaccharide biosynthesis and telomere-related terms) appear but are not coherent with the main theme, so the label emphasizes the tRNA-related functions. ","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009791","count":2},{"id":"GO:0009103","count":2},{"id":"GO:0009097","count":2},{"id":"GO:0006430","count":1},{"id":"GO:0070145","count":1}]},{"hash":"1472582376489152112","title":"Quinone biosynthesis and amino acid/fatty acid catabolism","description":"Most prominent terms describe biosynthesis of quinones (phylloquinone and menaquinone) and broad catabolic pathways (valine, phenylacetate) plus fatty acid beta-oxidation. This pattern suggests a cluster focused on quinone biosynthesis linked to energy metabolism and various catabolic routes, rather than signaling or stress responses.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0042372","count":6},{"id":"GO:0010124","count":6},{"id":"GO:0006574","count":6},{"id":"GO:0009234","count":6}]},{"hash":"2114658128570744739","title":"Unknown","description":"The GO terms span arginine and polyamine metabolism, post-translational modifications, translation, glucosamine metabolism, and angiogenesis with little cohesive function tying them together. Sparse connectivity reinforces the lack of a single representative theme, so an Unknown label is appropriate.","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006526","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0060358","count":1},{"id":"GO:0046208","count":1},{"id":"GO:0006474","count":1}]},{"hash":"1653932364729624708","title":"Diverse Metabolic Processes","description":"The proteins in this cluster show annotations across a wide range of metabolic activities\u2014from amino acid and nucleotide metabolism to vitamin biosynthesis, redox-related glutathione metabolism, and even hydrocarbon/halogen processing. This breadth suggests a general metabolic versatility rather than a single, cohesive pathway, hence a broad metabolism label.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":1},{"id":"GO:0097054","count":1},{"id":"GO:0043448","count":1},{"id":"GO:0070276","count":1},{"id":"GO:0009228","count":1}]},{"hash":"27253128741573500","title":"Amino acid catabolism and kynurenine pathway","description":"This cluster is driven by amino acid catabolic processes, especially L-alanine, L-threonine, L-glutamate, and L-lysine, along with the L-kynurenine and kynurenic acid branches of tryptophan metabolism. The presence of these terms suggests a cohesive theme around amino acid degradation and kynurenine pathway activity, with a few related biosynthetic steps (e.g., heme) and a broader metabolic signaling context (insulin response). Overall, the dominant signal points to amino acid catabolism and tryptophan-derived metabolite production.","confidence":"Medium","size":7,"edges":17,"triangles":19,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042853","count":5},{"id":"GO:0019441","count":3},{"id":"GO:0019878","count":3},{"id":"GO:0019518","count":3},{"id":"GO:0097053","count":3}]},{"hash":"981461501625783010","title":"RNA and protein methylation","description":"The top GO terms are dominated by methyltransferase activities: RNA cap formation (m7G), RNA methylation (guanine-N7, tRNA wobble modification), and various N-terminal or residue-specific protein methylations (arginine, glycine, serine, alanine). This suggests a module of methyltransferases targeting both RNA and proteins, with a few plant-specific terms that may reflect context rather than core function.","confidence":"High","size":7,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":2},{"id":"GO:0019919","count":2},{"id":"GO:0018013","count":2},{"id":"GO:0035572","count":2},{"id":"GO:0009877","count":2}]},{"hash":"1207417235249897828","title":"Neural development and synaptic signaling","description":"Based on the Top Terms, the cluster is enriched for neural-related processes: visual perception, cerebellar cortex development, and excitatory postsynaptic potential, along with receptor clustering. These terms point to brain development and synaptic signaling, with a few outliers (keratinocyte differentiation, neutrophil clearance, pancreatic juice secretion regulation) likely reflecting noise rather than a core theme. Overall, the neural/sensory function theme is strong.","confidence":"High","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0043113","count":6},{"id":"GO:0007601","count":6},{"id":"GO:0030216","count":6},{"id":"GO:0090648","count":5},{"id":"GO:0021695","count":5}]},{"hash":"2036009355692934873","title":"Integrin-ECM Signaling in Tissue Remodeling","description":"The top terms cluster around cell-ECM interactions (integrin signaling, hyaluronan metabolism) and processes governing cell adhesion, migration, differentiation, and proliferation (fibroblast/keratinocyte activity, Wnt/Hippo regulation, TGF-beta signaling, apoptosis). This points to coordinated extracellular matrix signaling and tissue remodeling or wound healing. The presence of an immune activation term is likely ancillary rather than core.","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":5},{"id":"GO:0030212","count":5},{"id":"GO:0002291","count":4},{"id":"GO:0010763","count":4},{"id":"GO:0060044","count":4}]},{"hash":"1198751695652827810","title":"Neurovascular development signaling","description":"The top GO terms cluster around PDGF, VEGF, and integrin signaling, ERK cascade activation, and various neural development processes (neuron development, retina vasculature morphogenesis, sympathetic ganglion development, neural crest migration). This combination indicates coordinated signaling governing neurovascular patterning and development, rather than a single pathway. ","confidence":"High","size":7,"edges":6,"triangles":2,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0048008","count":6},{"id":"GO:0007229","count":4},{"id":"GO:0048010","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0048666","count":4}]},{"hash":"2074568700938858789","title":"Neuronal development and immune signaling regulators","description":"This cluster mixes neuronal-focused terms (brain development, synaptic vesicle exocytosis, mechanical stimulus response) with immune-related terms (macrophage differentiation, NF-kappaB regulation, type II interferon production). The overlap suggests proteins that participate in neural development alongside modulation of immune pathways, possibly reflecting neural-immune crosstalk. However, the presence of unrelated terms (e.g., hair follicle morphogenesis, negative chemotaxis) reduces coherence, so the label remains tentative.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0010796","count":2},{"id":"GO:0031384","count":2},{"id":"GO:0030225","count":2},{"id":"GO:0071260","count":2}]},{"hash":"1889683852752308175","title":"Neuronal signaling and dendrite morphogenesis","description":"The GO terms cluster around neuronal communication and dendritic development (excitatory postsynaptic potential, dendrite morphogenesis, ephrin receptor signaling, Roundabout signaling). While there are broader signaling pathways (JNK, MAPKK, Hedgehog/SMO, PI3K) represented, the prominent emphasis on synaptic signaling and dendrite-related processes suggests a cohesive neuron-focused module rather than a general signaling mix. Confidence: Medium","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0048013","count":4},{"id":"GO:0031532","count":4}]},{"hash":"861314368688911197","title":"Neuropeptide signaling and autonomic cardiovascular regulation","description":"The cluster is defined by strong enrichment for neuropeptide signaling pathway and vasopressin-mediated regulation of arterial blood pressure, with supporting signals for dopamine uptake and smooth muscle/vascular differentiation, pointing to a core role in neuroendocrine control of autonomic cardiovascular function. Temperature and pain terms suggest broader stress response contexts but do not dominate the set.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0043950","count":6},{"id":"GO:0032651","count":6}]},{"hash":"928954732488490297","title":"Developmental organogenesis and sensory signaling","description":"The proteins cluster around GO terms tied to development of whole organisms and specific organs (multicellular organism development, inner ear development, thymus development, growth plate cartilage chondrocyte growth). There is also emphasis on signaling and receptor organization (receptor clustering, Hedgehog pathway regulation) and a sensory dimension (sensory perception of pain). While some terms are less coherent (proteasomal degradation regulation, cholesterol efflux), the dominant pattern points to developmental signaling guiding organogenesis, particularly sensory organs and immune-related tissues.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0043113","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0048839","count":2},{"id":"GO:0032435","count":2}]},{"hash":"990438760207074635","title":"Proviral Integration and DNA Transposition","description":"The GO terms point to genome integration processes typical of proviruses and transposable elements: establishment of integrated proviral latency, DNA integration, retrotransposition, and DNA transposition, along with viral entry into the host nucleus. While there are hints of host-symbiont interactions, the core signal is integration/transposition machinery and genome mobility, with a side note on replication. Confidence: Medium","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0046718","count":3}]},{"hash":"804939058389431415","title":"Neural and Cardiac Signaling and Ion Transport","description":"Top GO terms point to excitability and signaling in neural and cardiac tissues (neuronal action potential, pain perception, Purkinje-to-ventricular signaling, ventricular repolarization) and ion transport (sodium import), with brain-related regulation (circadian sleep/wake cycle) and broader developmental and stress responses. This suggests a cluster of proteins involved in excitable-cell signaling and ion homeostasis, spanning neural and cardiac functions. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0019228","count":3},{"id":"GO:0060453","count":3},{"id":"GO:0060307","count":3}]},{"hash":"902313270594766635","title":"Macrophage Innate Immunity: TLR4 Signaling and NLRP3 Inflammasome","description":"The cluster centers on macrophage activation, TLR4 signaling, NLRP3 inflammasome assembly, and cytokine production (IL-1, IL-18, IFN-\u03b1), with supporting actin remodeling, indicating a coherent innate immune activation module involving TLR4 sensing and inflammasome-driven inflammation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042116","count":1},{"id":"GO:0032741","count":1},{"id":"GO:0050711","count":1},{"id":"GO:0034142","count":1},{"id":"GO:0045356","count":1}]},{"hash":"1173703018327724109","title":"Axon guidance and neural development","description":"This cluster is enriched for neuronal wiring and development terms, including commissural neuron axon guidance, paranodal junction assembly, and neural crest\u2013derived structure formation (ventral trunk neural crest migration, sympathetic ganglion development). Retina-related terms (retina layer formation, retina vasculature morphogenesis) place it in neural development of the eye, with additional neuronal function indicated by regulation of synaptic vesicle endocytosis. The overarching theme is axon guidance within broader neural development.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0071679","count":5},{"id":"GO:1900242","count":5},{"id":"GO:0002175","count":5},{"id":"GO:0010842","count":5},{"id":"GO:1902378","count":4}]},{"hash":"1357080352306296079","title":"Neural crest development and axon guidance","description":"The top GO terms cluster around neural crest\u2013driven development (ventral trunk neural crest migration, autonomic nervous system, sympathetic ganglion development, neuronal migration to the hypothalamus) and axon guidance (semaphorin-plexin, neuropilin signaling, commissural guidance, paranodal junctions), indicating a cohesive theme of neural crest\u2013related nervous system formation and nerve pathfinding.","confidence":"High","size":7,"edges":10,"triangles":7,"max_degree":5,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:1902378","count":6},{"id":"GO:0036486","count":6},{"id":"GO:0061549","count":6},{"id":"GO:0061299","count":6},{"id":"GO:0043583","count":6}]},{"hash":"833737350177462569","title":"Neuro-immune signaling","description":"This cluster links neural processes (brain development, GABA signaling, calcium transport) with immune signaling pathways (T/B cell receptor signaling, IL-15/IL-1-mediated pathways) and general signaling regulation (Rho, acrosome-related regulation). The shared theme is signaling across neural and immune contexts, with calcium signaling as a common thread, though no single pathway dominates. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":4},{"id":"GO:0035023","count":4},{"id":"GO:2000344","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0006816","count":3}]},{"hash":"972826474003305849","title":"Retroviral DNA replication and integration","description":"The dominant GO terms point to steps in the retroviral life cycle: reverse transcription (RNA-templated DNA biosynthetic process), DNA replication and recombination, integration of viral DNA into the host genome, and establishment of proviral latency, along with viral entry into the host nucleus and manipulation of host pathways. This makes a retroviral infection/latency theme the best match for the cluster.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0006278","count":3},{"id":"GO:1903704","count":3},{"id":"GO:0075713","count":3}]},{"hash":"571402262612105595","title":"Neural development and axon guidance","description":"The GO terms point to neural development and axon pathfinding (defasciculation of motor neuron axon; ventral spinal interneuron fate; R8 cell development; pupal development), with related signaling concepts (receptor clustering) suggesting neural circuit organization; together these form a coherent theme around neural development and axon guidance, despite sparse internal connectivity. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043113","count":2},{"id":"GO:0010226","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0060579","count":1},{"id":"GO:0007415","count":1}]},{"hash":"558451624794902296","title":"Steroid Hormone Biosynthesis and Catabolism","description":"Most of the top GO terms point to steroid metabolism: estrogen biosynthetic process, testosterone biosynthetic process, steroid catabolic process, and androgen catabolic process, plus tetrahydrobiopterin biosynthesis which fuels steroid hydroxylases. While there are outliers like sporulation and lung development, the dominant signal is synthesis and breakdown of steroid hormones, justifying a label focused on steroid hormone metabolism.","confidence":"Medium","size":7,"edges":12,"triangles":7,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0030435","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0006703","count":4},{"id":"GO:0006666","count":4},{"id":"GO:0046677","count":4}]},{"hash":"1705551734619968036","title":"Head and sensory organ morphogenesis","description":"The GO terms cluster around development of sensory structures in the head, notably retina/eye and vestibular/otic regions, plus craniofacial morphogenesis (cranial skeleton, otic placode). A few terms on pigment cell differentiation and salivary gland morphogenesis suggest broader head/ectodermal development. Together, they point to head and sensory organ formation rather than a single narrow pathway.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0042673","count":1},{"id":"GO:0060118","count":1},{"id":"GO:0043049","count":1}]},{"hash":"263291942145276763","title":"Development of muscle, heart, and spinal cord","description":"The top GO terms point to developmental processes across cardiac, skeletal muscle, and neural (spinal cord) tissues, with supporting cytoskeletal dynamics (microtubule-based movement) and signaling activities. This suggests a broad developmental program coordinating tissue differentiation and cytoskeletal remodeling rather than a single specific function, making the chosen label representative and intuitive.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0021510","count":4},{"id":"GO:0007018","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0097011","count":4},{"id":"GO:0043547","count":3}]},{"hash":"68382113133468511","title":"Immune\u2013neural signaling and adhesion","description":"The terms include immune pathways (T cell receptor signaling, apoptotic and neutrophil clearance), various signaling cascades (prolactin, Smoothened/Hedgehog), neural development and plasticity (retinal ganglion axon guidance, long-term synaptic plasticity), and homophilic cell adhesion. This suggests a broad clustering around shared signaling and adhesion processes that span immune and neural contexts rather than a single cohesive pathway.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1902955","count":7},{"id":"GO:0043277","count":7},{"id":"GO:0038161","count":7},{"id":"GO:0050852","count":7},{"id":"GO:0097350","count":7}]},{"hash":"1947512766294142890","title":"Neural development and synaptic vesicle exocytosis","description":"The terms point to neuronal development and synaptic function, with emphasis on brain development, synaptic vesicle exocytosis, excitatory postsynaptic potentials, actin remodeling, and Rap signaling, suggesting a cohesive neural/synaptic cluster with vesicle trafficking and cytoskeletal dynamics; the other terms related to mating projection growth and hair follicle morphogenesis appear less representative.","confidence":"High","size":7,"edges":9,"triangles":4,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":6},{"id":"GO:0010796","count":6},{"id":"GO:0031384","count":6},{"id":"GO:2000300","count":6},{"id":"GO:0031069","count":5}]},{"hash":"112275962226876239","title":"Stress-Responsive Development and Apoptosis","description":"The cluster includes developmental terms (heart development, hippocampus development, head involution) and stress/response terms (hypoxia, hydrogen peroxide, xenobiotic, nicotine, antibiotic) plus apoptotic processes (nurse cell and ectopic germ cell death). This suggests a theme of developmental programs that are modulated by cellular stress and programmed cell death.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0001666","count":4},{"id":"GO:0042542","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0021766","count":4},{"id":"GO:0035234","count":3}]},{"hash":"1315330192819464956","title":"Neuronal development and synaptic signaling","description":"Top terms indicate roles in brain development, synaptic vesicle exocytosis, and excitatory postsynaptic potential, with actin remodeling and Rap signaling supporting synapse formation and intracellular transport. While a few terms relate to non-neuronal morphogenesis or motility, the dominant pattern is neuronal development and synaptic trafficking, making this label representative.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0010796","count":3},{"id":"GO:0031384","count":3},{"id":"GO:2000300","count":3},{"id":"GO:0031069","count":2}]},{"hash":"1052824849412567890","title":"Neuronal development and synaptic signaling","description":"Most terms center on nervous system development (brain development, nervous system development) and synaptic function (regulation of synaptic vesicle endocytosis, GABAergic synaptic transmission). This indicates a cluster enriched for neuronal development and synaptic communication, with a few outliers like ossification and keratinization that may reflect background annotation or diverse tissue expression.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":3},{"id":"GO:0007420","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0045176","count":2},{"id":"GO:0051932","count":2}]},{"hash":"955159768566168214","title":"Cell division and vesicle trafficking","description":"Top GO terms point to mitotic chromosome condensation, exit from mitosis, and nucleus organization, alongside membrane fission, Golgi retention, exosomal secretion, and abscission. This suggests a cluster of proteins coordinating nuclear/chromosome dynamics with membrane remodeling and vesicle trafficking during cell division. Some terms appear tissue-specific or obsolete, but the overall theme centers on mitosis coupled with vesicle remodeling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902188","count":2},{"id":"GO:0045053","count":2},{"id":"GO:0090148","count":2},{"id":"GO:0010458","count":2},{"id":"GO:0006997","count":2}]},{"hash":"1708757092554296162","title":"Nervous system development and axon guidance","description":"This cluster is dominated by GO terms related to nervous system development, axon guidance, and neural crest migration (paranode localization, neural crest migration, sympathetic ganglion development, ventral trunk neural crest), with supporting signaling pathways (phosphatidylinositol signaling) and axon-related processes, suggesting a cohesive role in neural development and axon pathfinding, despite a few angiogenesis-related terms that can accompany neural patterning.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002175","count":2},{"id":"GO:0007026","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0048015","count":2}]},{"hash":"759812174203695785","title":"Diverse Transmembrane Transporters","description":"The top GO terms point to transmembrane transport across the plasma membrane for xenobiotics, vitamins, sugars, ions, and related substrates, suggesting a cluster of membrane transporter proteins with broad substrate specificity, including xenobiotic and nutrient transport (e.g., sodium, arabinose, trehalose, selenite, nitrate-related processes, and L-ascorbic acid). This makes a cohesive label of diverse transmembrane transporters appropriate.","confidence":"High","size":7,"edges":16,"triangles":17,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":7},{"id":"GO:0035461","count":7},{"id":"GO:0042891","count":7},{"id":"GO:0042128","count":6},{"id":"GO:0035725","count":6}]},{"hash":"1374150294523061030","title":"Endosomal trafficking regulation","description":"The cluster includes terms directly tied to endosomal trafficking, notably regulation of endosome size and receptor recycling, which together point to membrane trafficking control. The presence of additional, unrelated or obsolete GO terms (e.g., DNA transposition, transcription regulation, photomorphogenesis) suggests some annotation noise or multifunctionality, so the most coherent interpretation centers on endosomal trafficking rather than a single other function.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0051036","count":1},{"id":"GO:0035249","count":1},{"id":"GO:0060316","count":1}]},{"hash":"1405645126701191009","title":"Neuropeptide signaling and vascular regulation","description":"Top GO terms cluster around neuropeptide signaling and its cardiovascular effects, including the neuropeptide signaling pathway, vasopressin-regulated blood pressure, and renin secretion, as well as neuromodulatory processes such as dopamine uptake regulation and smooth muscle relaxation. Together they define a neuroendocrine signaling cluster that modulates vascular function and blood pressure.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":7},{"id":"GO:0032651","count":7},{"id":"GO:0007218","count":7},{"id":"GO:2000724","count":7},{"id":"GO:0090075","count":7}]},{"hash":"797010225406713296","title":"ER stress and cell cycle regulation","description":"The most represented GO terms are ER unfolded protein response (UPR) and mitotic cell cycle transitions (G1/S and G2/M), suggesting a link between ER stress signaling and cell division control. Other terms are sparser or context-specific, so the label emphasizes the dominant themes.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030968","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0032026","count":3},{"id":"GO:0000082","count":2},{"id":"GO:1903251","count":2}]},{"hash":"536059984920096714","title":"Neurotransmission and thermogenesis","description":"This cluster centers on GO terms tied to nervous system signaling and temperature/pain responses, such as cellular response to temperature stimulus, diet-induced thermogenesis, sensory perception of pain, neuropeptide signaling pathway, and GABA secretion. These suggest a common theme of neuronal signaling with roles in thermoregulation and pain modulation, with other terms like muscle relaxation and vascular differentiation as downstream or ancillary effects. Due to some terms that are less directly connected (e.g., GTPase regulation, IL-1 beta production), the link is plausible but not narrowly defined.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0014051","count":3}]},{"hash":"1523664299460667321","title":"Innate Immune Activation","description":"The top GO terms are dominated by innate immune functions: phagocytosis recognition, complement activation (lectin pathway), basophil activation, and response to fungal origin. While there are a few developmental terms (kidney morphogenesis, cartilage condensation), the immune-related terms are the strongest signal, justifying a label centered on innate immune activation.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006910","count":4},{"id":"GO:0072287","count":4},{"id":"GO:0010572","count":4},{"id":"GO:0090403","count":4},{"id":"GO:0060355","count":4}]},{"hash":"821009977312099226","title":"DNA Transcription and Cell Cycle Regulation","description":"The proteins cluster around nuclear DNA processes: DNA-templated transcription (and its regulation), DNA integration signals, and cell cycle-related terms (cell division, chromosome segregation). This suggests a theme of transcription control tied to genome maintenance and cellular proliferation, despite a few outliers related to development or host interactions.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0075713","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0045316","count":1},{"id":"GO:0007469","count":1}]},{"hash":"980679598077750649","title":"Proviral integration and transposon activity","description":"The GO terms cluster around proviral latency, DNA integration, and DNA transposition, with related terms for viral entry into the host and nuclear penetration, plus RNA-templated DNA biosynthesis, suggesting a shared theme of viral genome integration and transposon-like DNA processing within the host genome.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0046718","count":4},{"id":"GO:0075732","count":3},{"id":"GO:0039651","count":3}]},{"hash":"1722651164903560379","title":"RNA Splicing and Processing","description":"The prominent GO terms are all tied to RNA metabolism, including tRNA processing, RNA splicing, spliceosomal tri-snRNP complex assembly, and mRNA processing, suggesting this cluster comprises spliceosome/RNA-processing factors. The developmental terms appear peripheral and do not define a unifying mechanism for the group.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":1},{"id":"GO:0008380","count":1},{"id":"GO:0000244","count":1},{"id":"GO:0007283","count":1},{"id":"GO:0006397","count":1}]},{"hash":"1860201054307622032","title":"Secreted protein processing and receptor trafficking","description":"The terms cluster around maturation/processing of signaling proteins (protein autoprocessing, IAPP processing, NGF processing) and regulation of receptor lifespan and recycling (LDL receptor catabolic/biosynthetic processes, receptor recycling). This points to a theme of protein maturation and secretion coupled with receptor trafficking. A couple of developmental terms (left-right symmetry, anterior lateral line development) may reflect broader signaling roles in development, making the theme plausible but not perfectly cohesive.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016540","count":2},{"id":"GO:0034231","count":1},{"id":"GO:0032805","count":1},{"id":"GO:1905598","count":1},{"id":"GO:0007368","count":1}]},{"hash":"1441050808231184502","title":"Macrophage-mediated vascular inflammation and foam cell formation","description":"The GO terms cluster around immune activation (immunological synapse, inflammatory cytokine production, acute inflammatory response) coupled with macrophage-driven lipid handling (foam cell differentiation, cholesterol storage) and vascular remodeling (fibronectin organization, endothelial proliferation), pointing to macrophage-mediated vascular inflammation and atherogenic processes.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001771","count":5},{"id":"GO:0043277","count":5},{"id":"GO:1900017","count":5},{"id":"GO:0002438","count":5},{"id":"GO:0010744","count":5}]},{"hash":"567418707589446587","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000378","count":6},{"id":"GO:0008306","count":6},{"id":"GO:1903608","count":6},{"id":"GO:1902775","count":6},{"id":"GO:0071042","count":6}]},{"hash":"781621464174382552","title":"Translation Initiation and Regulation","description":"This cluster is dominated by translation-related GO terms, including translation, formation of translation preinitiation complex, and translation reinitiation, indicating a focus on protein synthesis machinery and its control. Some associated terms point to stress- or circadian-linked gene expression modulation, but the central theme remains translation initiation and its regulation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0071549","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0002188","count":2},{"id":"GO:2000210","count":1}]},{"hash":"887564969325475454","title":"DNA Replication and Chromatin Regulation","description":"The cluster's top GO terms are dominated by DNA replication and chromatin-related processes (DNA replication; nucleosome positioning; heterochromatin maintenance; histone exchange). Additional terms touch on development and signaling (embryonic cranial skeleton morphogenesis; positive regulation of JNK cascade), suggesting a broader regulatory role, but the strongest signal is genome maintenance through replication and chromatin control.","confidence":"Medium","size":6,"edges":7,"triangles":1,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0046330","count":2},{"id":"GO:1902775","count":2},{"id":"GO:0071038","count":2}]},{"hash":"2209199804760728604","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":12,"triangles":11,"max_degree":5,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000378","count":6},{"id":"GO:0008306","count":6},{"id":"GO:1903608","count":6},{"id":"GO:1902775","count":6},{"id":"GO:0071042","count":6}]},{"hash":"1998389740299267173","title":"Fungal Cell Wall Biogenesis and Morphogenesis","description":"This cluster shows strongest signals for fungal-type beta-glucan biosynthesis and cell morphogenesis, with supporting terms for protein targeting to membranes and chaperone-assisted protein folding, suggesting roles in fungal cell-wall construction and shape changes. Other terms related to iron metabolism and stress responses may reflect broader cellular functions or annotation noise, but the core theme centers on wall biosynthesis and morphogenesis.","confidence":"Medium","size":6,"edges":11,"triangles":8,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070880","count":3},{"id":"GO:1902037","count":3},{"id":"GO:0016226","count":3},{"id":"GO:0006880","count":3},{"id":"GO:0000742","count":3}]},{"hash":"405261676616509540","title":"DNA replication and cell cycle regulation","description":"The cluster\u2019s top GO term is DNA replication, with additional terms pointing to centriole elongation and proteasomal protein turnover, all of which are tightly connected to cell cycle progression and genome maintenance. Other terms related to organelle trafficking and autophagy are present but appear less central, suggesting a primary theme around DNA synthesis and cell division with supportive roles in protein quality control.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0030420","count":4},{"id":"GO:0016562","count":4},{"id":"GO:0061738","count":4},{"id":"GO:1903724","count":4}]},{"hash":"1206307670879163644","title":"Plant nucleolar ribosome biogenesis and chromatin dynamics","description":"This cluster centers on nucleolar functions like ribosome biogenesis and maintenance of rDNA, alongside chromatin-level processes such as meiotic/mitotic chromosome condensation, synaptonemal complex assembly, and heterochromatin formation. The inclusion of amyloplast organization and gravitropism suggests a plant-specific context, reinforcing a theme of nucleolar and chromatin regulation in plants.","confidence":"High","size":6,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0030466","count":2},{"id":"GO:0009660","count":1},{"id":"GO:0043007","count":1},{"id":"GO:0010032","count":1}]},{"hash":"1592209302446219093","title":"Nuclear RNA Processing and Export","description":"The GO terms cluster around nuclear RNA metabolism: mRNA splicing via spliceosome, regulatory RNA silencing, nuclear pore organization, NLS-dependent nuclear import, and mRNA export (including responses to heat stress). Together, these indicate a cohesive module of nuclear RNA processing and export machinery, with some ties to RNA silencing, so the label reflects this nuclear RNA processing/transport theme.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048026","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0006999","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0072417","count":2}]},{"hash":"1507082364710322647","title":"Translation Initiation and Reinitiation","description":"The top GO terms cluster around translation initiation, formation of the preinitiation complex, and translation reinitiation (including viral IRES-related initiation and termination-reinitiation). Although there are a few outliers (steroid signaling, transcription, glial fate), the strongest shared theme is control of protein synthesis at the initiation stage.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071383","count":2},{"id":"GO:0032933","count":2},{"id":"GO:0015991","count":2},{"id":"GO:0075525","count":2},{"id":"GO:0006351","count":2}]},{"hash":"250745696563891694","title":"Embryonic Development and Multilineage Differentiation","description":"The top GO terms point to developmental processes across tissues, including skeletal morphogenesis (embryonic cranial skeleton), cerebellar cortex development, and myoblast differentiation, suggesting skeletal and neural development. Additional terms indicate hematopoietic/immune differentiation (myeloid progenitor differentiation, neutrophil clearance) and fundamental gene regulation (DNA replication, DNA-templated transcription). Some terms touch neural activity and environmental responsiveness, which fits nervous system maturation. Overall, the cluster appears to reflect broad developmental programs spanning skeletal, neural, and immune lineages rather than a single pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0002318","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0090648","count":2}]},{"hash":"1266469355643120220","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":13,"triangles":12,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":3},{"id":"GO:0000378","count":2},{"id":"GO:0008306","count":2},{"id":"GO:1903608","count":2},{"id":"GO:1902775","count":2}]},{"hash":"142502957148025309","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":9,"triangles":4,"max_degree":5,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0039530","count":4},{"id":"GO:0000378","count":4},{"id":"GO:0008306","count":4},{"id":"GO:1903608","count":4},{"id":"GO:1902775","count":4}]},{"hash":"1586581003681957675","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044205","count":2},{"id":"GO:0006207","count":2},{"id":"GO:0042594","count":2},{"id":"GO:0006552","count":2},{"id":"GO:0001889","count":2}]},{"hash":"1866964543816892926","title":"Chromatin organization and epigenetic regulation","description":"The top GO terms converge on chromatin-level processes: CENP-A containing chromatin assembly, heterochromatin formation, histone methylation regulation, and nucleus organization, along with transcriptional regulation by RNA polymerase II. While a few terms touch on differentiation programs (muscle, cardiac, B cell, spermatid), these likely reflect downstream effects or shared regulatory modules rather than defining a single pathway. Overall, this cluster aligns with chromatin architecture and epigenetic control.","confidence":"Medium","size":6,"edges":8,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0042692","count":2},{"id":"GO:0003209","count":2},{"id":"GO:2000973","count":2},{"id":"GO:0007286","count":2}]},{"hash":"425929787791429264","title":"Cerebellar architecture and microtubule dynamics","description":"The proteins are annotated with cerebellar granular layer and Purkinje cell layer structural organization, indicating a role in cerebellar tissue architecture. In addition, several GO terms point to microtubule-based processes (spindle assembly, plus-end directed microtubule sliding, nuclear migration along microtubule) and dendritic transport, suggesting a theme of microtubule-driven organization and transport in cerebellar neurons.","confidence":"High","size":6,"edges":10,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0021685","count":6},{"id":"GO:0000742","count":6},{"id":"GO:0051255","count":6},{"id":"GO:0030473","count":6},{"id":"GO:0000073","count":6}]},{"hash":"2035512324786278319","title":"Synaptic signaling and dendrite morphogenesis","description":"The proteins in this cluster are associated with neuronal communication and structure, evidenced by terms like excitatory postsynaptic potential, dendrite morphogenesis, ephrin receptor signaling, and JNK pathway modulation, which together point to synaptic signaling and cytoskeletal changes driving dendrite development rather than general metabolic functions.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033138","count":3},{"id":"GO:0060079","count":2},{"id":"GO:0031914","count":2},{"id":"GO:0043552","count":2},{"id":"GO:0048013","count":2}]},{"hash":"2078849161372497201","title":"Neural crest and brain vascular development","description":"The cluster is enriched for terms tied to embryonic development, notably neural crest cell migration, brain development, and endothelial proliferation, with additional vascular migration regulation terms. Despite some obsolete or nonspecific terms, the shared theme points to neurovascular development and neural crest\u2013driven morphogenesis.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0001935","count":1},{"id":"GO:0060065","count":1},{"id":"GO:0030263","count":1}]},{"hash":"424697495664800733","title":"Innate Immune Signaling and Apoptosis","description":"The top GO terms cluster around innate immunity (innate immune response, defense against virus, TLR4 signaling) and programmed cell death (apoptotic process, pyroptotic inflammation, ubiquitination), suggesting the proteins participate in immune signaling and apoptosis regulation. Some terms like mitotic spindle assembly and brain development may be less connected, likely background or multifunctional roles.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":5},{"id":"GO:0070269","count":4},{"id":"GO:1990001","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0016567","count":4}]},{"hash":"613143461918123770","title":"Retroviral integration and host entry","description":"This cluster centers on retrovirus-related processes: DNA integration, recombination, RNA-templated DNA biosynthesis, and establishment of integrated proviral latency, along with viral penetration into the host nucleus and symbiont entry into host cells, indicating a retroviral life cycle and host interaction. The presence of negative regulation of siRNA processing suggests host defense involvement, reinforcing a virus-host dynamic rather than a purely cellular division program.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0006260","count":2}]},{"hash":"2112777429596159105","title":"Unknown","description":"GO terms span morphogenesis, muscle growth, neural signaling, and ion transport with no single shared function, so no coherent cluster theme can be inferred.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903849","count":2},{"id":"GO:0003180","count":2},{"id":"GO:0071372","count":2},{"id":"GO:1900025","count":2},{"id":"GO:0021654","count":2}]},{"hash":"671269332151812986","title":"Sugar-acid and small-molecule catabolism","description":"The listed GO terms cluster around diverse catabolic pathways for small molecules: N-acetylneuraminate, D-glucarate, acetate, propionate, and other sugar-acid catabolism processes, with a lone cytoplasmic translation term likely reflecting broad housekeeping annotation. This combination suggests the proteins participate in general carbon-source breakdown rather than a single specific pathway, hence a label centered on small-molecule sugar/acid catabolism.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019877","count":1},{"id":"GO:0009089","count":1},{"id":"GO:0019262","count":1},{"id":"GO:0019470","count":1},{"id":"GO:0046176","count":1}]},{"hash":"1279995953490879798","title":"Mitochondrial energy production and nucleotide biosynthesis","description":"The cluster is enriched for GO:0006120 (mitochondrial electron transport, NADH to ubiquinone) and several nucleotide biosynthetic processes (dUDP, dGTP, dTDP, TMP, DNA biosynthesis), suggesting a cohesive theme around mitochondrial energy metabolism and de novo nucleotide synthesis. A few additional terms (cadmium/estrogen response, myoblast differentiation) may reflect broader regulatory associations but do not override the core signal.","confidence":"Medium","size":6,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":2},{"id":"GO:0046092","count":1},{"id":"GO:0006227","count":1},{"id":"GO:0046070","count":1},{"id":"GO:0006233","count":1}]},{"hash":"21144772904823094","title":"Central carbon metabolism and amino acid pathways","description":"Based on the prominent glycolytic and TCA-cycle terms (glycolytic process, tricarboxylic acid cycle, 2-oxoglutarate metabolic process) along with amino-acid related terms (glycine decarboxylation and biosynthesis; tyrosine, threonine), the cluster seems to center on fundamental carbon metabolism and amino acid turnover. The antibiotic biosynthetic term is present but not dominant, so the core theme is energy generation and amino acid metabolism.","confidence":"High","size":6,"edges":8,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0006103","count":2},{"id":"GO:0006099","count":2},{"id":"GO:0006096","count":2}]},{"hash":"1057078708202576163","title":"Unknown","description":"Terms are scattered across amino acid catabolism, tRNA charging, nucleotide biosynthesis, spermatid differentiation, and protein complex assembly, with only partial overlap (two tRNA synthetase terms). This makes a single cohesive function unclear.","confidence":"","size":6,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006574","count":2},{"id":"GO:0006420","count":1},{"id":"GO:0006426","count":1},{"id":"GO:0048515","count":1}]},{"hash":"693732379064864766","title":"Lipid and metabolite biosynthesis","description":"The top GO terms are dominated by biosynthetic processes for lipids and related metabolites (sterol, ether lipid, wax, poly-hydroxybutyrate) and even antibiotic biosynthesis, suggesting the cluster groups proteins involved in lipid and small-molecule biosynthesis. Some outliers (response to cocaine, cytolysis) exist but do not override the lipid/metabolite biosynthesis theme. This supports a moderate confidence in labeling as lipid/metabolite biosynthesis.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016126","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0017000","count":2}]},{"hash":"463633433808043614","title":"Unknown","description":"Top terms are empty and there are no edges or interactions to define a shared function; despite mentions of ReCIPE re-added proteins, no common GO term or network pattern is evident for these six proteins. Therefore, Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"875380949993252429","title":"Unknown","description":"The top GO terms show a mix of stress- and regulatory-related processes (cellular response to exogenous dsRNA, cellular response to cadmium ion, negative regulation of protein modification, regulation of histone methylation), along with proteostasis and even photosynthesis, and several terms are obsolete. There are no interactions among the proteins (Edges 0), so there isn't a clear, single biological function tying the cluster together. Therefore the label Unknown is most appropriate, with no clear confidence in a specific function.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071360","count":4},{"id":"GO:1903646","count":4},{"id":"GO:0051348","count":4},{"id":"GO:1902391","count":4},{"id":"GO:2001162","count":4}]},{"hash":"118850918455182578","title":"Ribosome Biogenesis and Translation","description":"The top GO terms are dominated by ribosome-related processes: cytoplasmic translation, ribosome biogenesis, and ribosomal small subunit biogenesis, plus tRNA modification. This points to proteins involved in assembling ribosomes and carrying out protein synthesis. A few terms (skin development, insulin response) are present but less central, so the main theme is ribosome biogenesis and translation.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0019042","count":1},{"id":"GO:0090529","count":1},{"id":"GO:0006400","count":1}]},{"hash":"1963673833171082932","title":"Neuronal synaptic transmission and development","description":"The top GO terms cluster around synaptic activity and neuronal maturation, especially excitatory postsynaptic potential and vesicle exo-/endocytosis, with substantia nigra development supporting a brain- and neuron-focused theme. Some outliers (xenobiotic response, ossification, heart rate regulation, mitotic cycle) may reflect broader cellular roles or annotation noise, but the dominant signal is neuronal synaptic function and development.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:0035690","count":2},{"id":"GO:1900242","count":2},{"id":"GO:2000300","count":2},{"id":"GO:0043931","count":2}]},{"hash":"444181426449881953","title":"Innate antiviral response and pyroptosis","description":"The top GO terms are dominated by innate immune and antiviral functions, including pyroptotic inflammatory response, cellular response to dsRNA, type I interferon response, innate immune response, defense against virus by host, and mitochondrial distribution. This points to a coherent theme of viral sensing, antiviral signaling, and pyroptotic inflammation within the cluster. Some terms (e.g., regulation of GPCR signaling, gibberellic acid signaling) appear less central and may reflect broader regulatory roles or annotation noise, but do not override the core antiviral/pyroptosis theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070269","count":4},{"id":"GO:0008277","count":4},{"id":"GO:0009938","count":4},{"id":"GO:0071360","count":4},{"id":"GO:1990001","count":4}]},{"hash":"702258513519424500","title":"Unknown","description":"The terms span immune signaling (T cell receptor), neural development and glial/neuronal differentiation (cerebellar cortex formation, Bergmann glia differentiation, axon regeneration), metabolic signaling (insulin signaling, glucose-related regulation), and cell cycle/kinetochore processes, with no clear single functional theme tying all proteins together. A cohesive, representative label isn\u2019t apparent.","confidence":"","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0050852","count":4},{"id":"GO:0021697","count":4},{"id":"GO:0008285","count":4},{"id":"GO:0060020","count":4},{"id":"GO:0048679","count":4}]},{"hash":"2156712004015794906","title":"Apoptosis and DNA Damage Response","description":"The top GO terms cluster around apoptotic process and DNA catabolic/recombinational activities, plus stress responses to xenobiotics and cAMP signaling; together they point to a module involved in DNA damage sensing/processing and programmed cell death.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:0006308","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0090502","count":4},{"id":"GO:0071320","count":4}]},{"hash":"112456812183049294","title":"Light-regulated circadian transcription and mRNA decay","description":"This cluster prominently features GO terms for far-red light signaling and phototransduction, regulation of circadian rhythm, and transcription control, plus nuclear mRNA decay and miRNA-mediated silencing, indicating a cohesive theme of light-responsive transcription linked to post-transcriptional regulation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0010018","count":2},{"id":"GO:0042753","count":2},{"id":"GO:0009585","count":2},{"id":"GO:0000290","count":1}]},{"hash":"283922664326217189","title":"Developmental vesicle trafficking and growth","description":"Top GO terms indicate ER-Golgi trafficking (COPII budding, retrograde transport), ribosome biogenesis, and mitosis, along with brain development and multicellular growth. This suggests a theme of coordinated cellular logistics and proliferation during development. Hence the label reflects both intracellular trafficking and developmental growth processes.","confidence":"High","size":6,"edges":6,"triangles":0,"max_degree":3,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0090114","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0000747","count":3}]},{"hash":"829474962275561527","title":"Unknown","description":"The term list includes regulation of transcription, chromatin dynamics, stem cell maintenance, post-translational modification, and several distinct regulatory processes, but there is no single cohesive function tying these proteins together, and the network shows no interactions, making a specific, unified label inappropriate.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0043486","count":1},{"id":"GO:0035019","count":1},{"id":"GO:0010922","count":1},{"id":"GO:0001519","count":1}]},{"hash":"1438674450155722290","title":"DNA transposition and proviral integration","description":"The top GO terms emphasize DNA integration, transposition, DNA recombination, and RNA-templated DNA biosynthesis, with hints of proviral latency. This combination points to mobility and integration machinery of genetic elements such as transposons and retroelements, i.e., transposases/integrases and related recombination enzymes. High confidence that the label reflects the cluster\u2019s function.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0075713","count":4},{"id":"GO:0046718","count":4},{"id":"GO:0006313","count":4},{"id":"GO:0051301","count":2}]},{"hash":"1345683837453141083","title":"Developmental polarity and axis formation","description":"The top GO terms cluster around developmental processes and cell polarity, including left/right asymmetry, organ and tissue development, and polarity-driven events such as neuroblast polarity, pronuclear migration, and centrosome/centrosome-related localization. Directional processes like auxin polar transport also reinforce a theme of patterning and axis establishment across organisms, suggesting the cluster represents development guided by cellular polarity rather than a single pathway.","confidence":"Medium","size":6,"edges":8,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060430","count":2},{"id":"GO:0061371","count":1},{"id":"GO:2000012","count":1},{"id":"GO:0035046","count":1},{"id":"GO:0045201","count":1}]},{"hash":"1278512273869917412","title":"Retroviral integration and latency","description":"The terms cluster around steps of a retroviral life cycle: reverse transcription (RNA-templated DNA synthesis), DNA recombination and DNA integration into the host genome, DNA replication, and establishment of integrated proviral latency, along with viral penetration into the host nucleus. Some terms also touch on host-microbe interactions (symbiont entry and apoptosis), but the dominant theme is proviral integration and latency. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":4},{"id":"GO:0006278","count":3},{"id":"GO:1903704","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3}]},{"hash":"283351412494382991","title":"TLR-driven inflammation and cytokine production","description":"This cluster is dominated by GO terms for Toll-like receptor signaling (TLR4/TLR2), including TIRAP-dependent pathways, and downstream inflammatory mediators such as IL-6 and chemokines, pointing to innate immune activation. Ancillary terms like nuclear import and GTPase regulation appear secondary to the core TLR-cytokine theme.","confidence":"High","size":6,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006607","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0034137","count":3},{"id":"GO:0035665","count":3},{"id":"GO:0045410","count":3}]},{"hash":"849831545717860079","title":"Developmental cell adhesion and synaptic signaling","description":"The terms cluster around cell adhesion and organization (substrate adhesion-dependent spreading, receptor clustering, heterophilic cell-cell adhesion) plus neural/synaptic activity (synapse assembly, neurotransmitter secretion) alongside broad developmental contexts (eye morphogenesis, cardiac morphogenesis, venous endothelial differentiation). This points to proteins involved in developmental cell interactions and signaling that span neural and vascular development, rather than a single fixed pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007416","count":2},{"id":"GO:0034446","count":2},{"id":"GO:0048593","count":2},{"id":"GO:0003213","count":2},{"id":"GO:0006958","count":2}]},{"hash":"1948746976952643694","title":"Vascular ECM Remodeling and Cell Adhesion","description":"The terms point to extracellular matrix organization (collagen fibril organization), vascular regulation (vasoconstriction, endothelial cell migration), and cell\u2013cell interactions (heterotypic adhesion, apoptotic cell recognition), suggesting a theme of vascular tissue remodeling and endothelial\u2013matrix interactions. Some terms are peripheral (like triglyceride homeostasis), but the core cluster centers on ECM and vascular cell dynamics, supporting a cohesive label.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050714","count":2},{"id":"GO:0070328","count":1},{"id":"GO:0030210","count":1},{"id":"GO:0045907","count":1},{"id":"GO:0030199","count":1}]},{"hash":"174861619521921515","title":"Neuropeptide Signaling and ER Processing","description":"This cluster shows ER-associated functions (calcium ion homeostasis, protein folding) together with neuropeptide-related signaling terms (neuropeptide signaling pathway, pheromone biosynthetic process). The combination suggests proteins involved in producing and processing secreted signaling peptides that mediate communication, potentially linking ER protein handling with peptide-based signaling. The additional terms on apoptosis and Rac signaling are less central but may reflect broader stress-response and signaling cross-talk.","confidence":"Low","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032469","count":1},{"id":"GO:0034975","count":1},{"id":"GO:0042811","count":1},{"id":"GO:0007218","count":1},{"id":"GO:0008625","count":1}]},{"hash":"218053034589452450","title":"Developmental morphogenesis across tissues","description":"This cluster shows GO terms across bone, neural, heart development, and general multicellular development (e.g., positive regulation of osteoblast differentiation, axon guidance, forebrain development, ventricular/artery morphogenesis, and cell-matrix adhesion). The common thread is tissue- and organ-wide development and morphogenesis rather than a single pathway, supporting the label Developmental morphogenesis across tissues.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0045669","count":5},{"id":"GO:0032331","count":5},{"id":"GO:0097155","count":5},{"id":"GO:0030900","count":5},{"id":"GO:0003222","count":5}]},{"hash":"1031300904635728587","title":"Unknown","description":"The proteins show a highly heterogeneous set of GO terms (photosynthesis, cytokinin signaling, cadmium response, heart development, centrosome maintenance, mitotic regulation) with several obsolete annotations, and there are no shared functions or pathways binding them together. The lack of edges in the cluster further suggests it does not reflect a cohesive biological role, so an Unknown label with no confidence is appropriate.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:1903646","count":6},{"id":"GO:2001162","count":6},{"id":"GO:0071276","count":6},{"id":"GO:0015979","count":6},{"id":"GO:1903070","count":6}]},{"hash":"1602216665018025966","title":"ERAD Regulation","description":"The top GO terms cluster around ER-associated degradation, ubiquitin-dependent proteolysis, and ER-to-cytosol transport, notably involving the VCP-NPL4-UFD1 complex, which together point to ER quality control and proteostasis as the core function of this cluster. Some other terms like prostaglandin biosynthesis and neural development appear incidental; however, the ERAD-related terms provide a coherent unifying theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:1903070","count":1},{"id":"GO:1904153","count":1},{"id":"GO:1903061","count":1},{"id":"GO:1904240","count":1}]},{"hash":"269577600643997415","title":"Immune and Neural Signaling","description":"The top terms point to a mix of signaling pathways (T cell receptor, prolactin, Hedgehog/smoothened, neuronal synaptic plasticity) and neural guidance (retinal ganglion axon guidance) along with cell adhesion, suggesting proteins involved in general cell communication and interaction across immune and nervous system contexts. A few terms refer to clearance, but the prevalent theme is diverse signaling and connectivity rather than a single pathway, so a medium level of confidence is appropriate.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1902955","count":5},{"id":"GO:0043277","count":5},{"id":"GO:0038161","count":5},{"id":"GO:0050852","count":5},{"id":"GO:0097350","count":5}]},{"hash":"1584794546305722747","title":"Axon Guidance and Synapse Assembly","description":"This cluster contains GO terms centered on neuronal connectivity\u2014paranodal junction assembly, juxtaparanode localization, axon guidance signaling, and synapse/axon extension\u2014indicating roles in guiding axons and forming synapses. While a couple terms pertain to broader development (neural crest migration, heart morphogenesis), the dominant pattern is neuronal projection guidance and synapse organization.","confidence":"High","size":6,"edges":10,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030913","count":3},{"id":"GO:0071205","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0036486","count":2},{"id":"GO:1902287","count":2}]},{"hash":"1426800074327474034","title":"Unknown","description":"This cluster shows a very mixed set of GO terms, including mRNA splicing, spermatogenesis, immune response, transcription regulation, and even nitrate assimilation. There is no single dominant function or pathway that ties the majority of proteins together, beyond a loose association with nuclear/nucleic-acid processing in a few cases. Because of this heterogeneity, there isn't a meaningful specific label other than Unknown.","confidence":"","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0007638","count":1},{"id":"GO:1903026","count":1},{"id":"GO:0045071","count":1},{"id":"GO:0007286","count":1}]},{"hash":"112465676556617533","title":"Neuropeptide Signaling and Cardiovascular Regulation","description":"The set centers on neuropeptide signaling, vasopressin- and renin-mediated pathways, dopamine uptake in synapses, and vascular smooth muscle regulation, which collectively underlie neuroendocrine control of blood pressure. A few immune-related terms are present but do not override the cardiovascular-neuropeptide theme.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":6},{"id":"GO:0032651","count":6},{"id":"GO:0007218","count":6},{"id":"GO:2000724","count":6},{"id":"GO:0090075","count":6}]},{"hash":"935512865762763341","title":"Neural crest migration and neural development","description":"The Top Terms center on neural crest cell migration and nervous system patterning (ventral trunk neural crest cell migration, neural crest migration in autonomic NS development, sympathetic ganglion development, commissural neuron axon guidance, retinal morphogenesis, and GnRH neuronal migration), suggesting a cohesive theme of neural crest\u2013driven development; a few outlier terms (complement activation, transcriptional regulation) are present but do not redefine the cluster\u2019s main function.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0045880","count":1},{"id":"GO:1902378","count":1},{"id":"GO:0036486","count":1}]},{"hash":"16864502852058297","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000453","count":2},{"id":"GO:0017183","count":2},{"id":"GO:0050843","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0019354","count":2}]},{"hash":"1389508176108138594","title":"Skeletal and neural development","description":"The top GO terms are dominated by skeletal development (osteoblast differentiation, skeletal system development) and neural development (forebrain and spinal cord development), with a note on organ morphogenesis (branching morphogenesis). This points to a developmental program coordinating bone and nervous system formation, with auxiliary terms like hypoxia response and cell survival often observed during morphogenesis. Confidence: High","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045669","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0048754","count":2},{"id":"GO:0001501","count":2}]},{"hash":"1463274434738218845","title":"Glycosaminoglycan Biosynthesis and Sulfation","description":"This cluster centers on biosynthesis of glycosaminoglycans like heparan sulfate, chondroitin sulfate, and dermatan sulfate, plus protein sulfation and sulfate metabolism, indicating a cohesive role in proteoglycan assembly and sulfation.","confidence":"High","size":6,"edges":6,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":2},{"id":"GO:0030206","count":2},{"id":"GO:0060065","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0006805","count":1}]},{"hash":"1036362209778718939","title":"Amino acid biosynthesis and nitrogen metabolism","description":"The top terms cluster around biosynthetic and metabolic processes for amino acids (L-arginine, citrulline), biotin, and the urea cycle, plus related biosynthesis like antibiotic biosynthesis. While a few terms are unrelated (mRNA capping, responses to stimuli), the dominant theme is biosynthesis/metabolism of amino acids and nitrogen-containing compounds, suggesting a coherent metabolic cluster.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0071499","count":1},{"id":"GO:0006526","count":1},{"id":"GO:0000053","count":1}]},{"hash":"1248541406528464308","title":"Unknown","description":"The GO terms in this cluster are highly diverse (RNA capping, methylation, ribosome biogenesis, various biosynthetic pathways, virion attachment, and even obsolete aging and cocaine response), with no clear single function tying the proteins together and no edges among them. This lack of a cohesive theme suggests the cluster cannot be named with a specific biological function.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001300","count":4},{"id":"GO:0042220","count":4},{"id":"GO:0006370","count":4},{"id":"GO:0032259","count":4},{"id":"GO:0016126","count":4}]},{"hash":"895927202235896165","title":"Steroid Hormone Biosynthesis and Lipid Metabolism","description":"The top GO terms are dominated by estrogen and testosterone biosynthesis, plus steroid catabolic processes (androgen/steroid), indicating a core focus on steroid hormone production and turnover. Additionally, sphingolipid biosynthesis signals lipid metabolism involvement. A few terms (lung development, oxidation-reduction, antibiotic response) appear as broader or secondary associations but do not override the primary steroid/lipid theme.","confidence":"High","size":6,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0006703","count":4},{"id":"GO:0006666","count":4},{"id":"GO:0046677","count":4},{"id":"GO:0061370","count":4}]},{"hash":"2203118818613153772","title":"Carbohydrate biosynthesis and glycosylation","description":"These proteins appear linked to carbohydrate metabolism and glycosylation, including starch/glycogen/sucrose biosynthesis, sugar responses, and GPI-anchor/protein glycosylation processes. Although a few terms are obsolete, the common thread is sugar-related biosynthesis and glycosylation pathways.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072708","count":5},{"id":"GO:0019252","count":5},{"id":"GO:0005985","count":5},{"id":"GO:0097502","count":5},{"id":"GO:0005978","count":5}]},{"hash":"1333732719732882483","title":"Lipoprotein remodeling and cholesterol transport","description":"Based on the GO terms, the proteins cluster around lipoprotein remodeling across HDL, LDL, and VLDL particles, along with triglyceride and cholesterol handling (absorption, digestion, transport). Although there are no edges among them, the shared function is clearly lipid metabolism and lipoprotein remodeling. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034375","count":5},{"id":"GO:0070328","count":5},{"id":"GO:0009395","count":5},{"id":"GO:0034374","count":5},{"id":"GO:0030299","count":5}]},{"hash":"975792899002671566","title":"Broad vertebrate tissue development","description":"Despite diverse GO terms, several entries point to developmental processes across different tissues (brain, retina, bone/osteoblast, male gonad). Some terms indicate signaling/immune regulation (I-kappaB phosphorylation, type II interferon production) that can intersect development but do not define a single cohesive pathway. The strongest shared theme is broad tissue development across multiple organ systems, so this label is a representative high-level description of the cluster.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032609","count":3},{"id":"GO:0010572","count":3},{"id":"GO:0007252","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0002076","count":2}]},{"hash":"2295797512976824252","title":"Ion and sugar transmembrane transporters","description":"This cluster is dominated by GO terms for transmembrane transport of ions (sodium, potassium, phosphate), sugars (arabinose, galactose), and related substrates (nitrate, xenobiotics), plus a vesicle-related transport term (neurotransmitter loading into synaptic vesicle). The common thread is transporter activity moving diverse solutes across membranes, with a core emphasis on membrane transport functions. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0042128","count":3},{"id":"GO:0015751","count":3},{"id":"GO:0098700","count":3},{"id":"GO:0015757","count":3}]},{"hash":"510471229075031370","title":"Cytoskeleton-Driven Adhesion and Migration","description":"The cluster\u2019s top GO terms center on cytoskeletal dynamics (stress fiber assembly; dendrite morphogenesis; radial glial scaffold formation), cell\u2013cell and cell\u2013substrate adhesion (epithelial adhesion; substrate-dependent spreading), and cell movement (hemocyte migration; negative chemotaxis). This points to a cohesive role in remodeling the cytoskeleton to enable adhesion and movement across diverse cell types, including neurons, glia, epithelial, and immune cells. Ubiquitination appears as a general regulatory layer but is not the defining theme. ","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0050919","count":2},{"id":"GO:0010745","count":2},{"id":"GO:0035099","count":2},{"id":"GO:0043149","count":2}]},{"hash":"1514726295318598468","title":"Steroid and Sphingolipid Biosynthesis with Lung Development","description":"The top GO terms point to steroid hormone production (estrogen, testosterone, androgen biosynthesis) and sphingolipid biosynthesis, indicating a lipid/steroid metabolism\u2013driven cluster. While lung development appears, the strongest shared function among most terms is lipid and steroid biosynthesis and turnover, with some contextual development signal. Some terms (redox, antibiotic response) seem less connected, but do not override the core theme.","confidence":"Medium","size":6,"edges":6,"triangles":1,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0006703","count":3},{"id":"GO:0006666","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0061370","count":3}]},{"hash":"1120972323659645880","title":"Angiogenesis and coagulation signaling","description":"The dominant GO terms point to vascular processes: platelet aggregation, blood coagulation, endothelial cell migration, and angiogenesis, supported by Tie signaling and cell-matrix adhesion. This combination suggests a cluster centered on vascular remodeling, angiogenesis, and hemostasis rather than a single niche function.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070527","count":5},{"id":"GO:0007160","count":5},{"id":"GO:2000446","count":3},{"id":"GO:0072377","count":3},{"id":"GO:0043536","count":3}]},{"hash":"553169919592875765","title":"Neuronal synaptic signaling and vesicle trafficking","description":"The prominent terms include long-term synaptic potentiation, reelin-mediated signaling, and protein localization to the cortical microtubule cytoskeleton, all converging on neuronal communication and vesicle transport. This suggests a cohesive theme of synaptic signaling and cytoskeletal trafficking, despite a few miscellaneous metabolic/DNA repair terms that are less representative.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000616","count":2},{"id":"GO:0006098","count":1},{"id":"GO:0019854","count":1},{"id":"GO:0006281","count":1},{"id":"GO:0042732","count":1}]},{"hash":"945112092002085428","title":"Neural development and transcriptional regulation","description":"The top GO terms point to neural development (neural precursor proliferation, neuron projection development, multicellular organism development) and gene-regulatory processes (alternative splicing via spliceosome, chromatin binding). Together, they suggest a cluster of proteins that influence neural development through transcriptional and post-transcriptional control. The additional metabolic biosynthesis terms appear incidental rather than defining the core function. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097054","count":2},{"id":"GO:2000179","count":2},{"id":"GO:0009635","count":2},{"id":"GO:0009228","count":2},{"id":"GO:0010976","count":2}]},{"hash":"988997384064404041","title":"Keratinocyte development and wound healing","description":"This cluster centers on skin epidermal biology: keratinocyte development, epithelial morphogenesis, hair follicle morphogenesis, and wound healing, with related cytoskeletal remodeling and migration regulation. The GO terms point to skin epithelial morphogenesis, wound repair processes, and hair follicle formation, supported by cytoskeletal and trafficking activities typical of keratinocytes during these processes.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0044319","count":4},{"id":"GO:0051683","count":3},{"id":"GO:0090051","count":3},{"id":"GO:0003382","count":3},{"id":"GO:0043149","count":3}]},{"hash":"738649276004610634","title":"Cytoskeleton assembly and intracellular transport","description":"This cluster centers on cytoskeleton-related processes, with prominent terms for tubulin complex assembly and actin filament branching, plus regulation of intracellular protein transport, suggesting involvement in cytoskeleton dynamics and trafficking. Some developmental and signaling terms appear as noise, but the core signal is cytoskeletal organization and transport.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007021","count":2},{"id":"GO:0072321","count":1},{"id":"GO:0006626","count":1},{"id":"GO:0045039","count":1},{"id":"GO:0031069","count":1}]},{"hash":"248137086356790996","title":"Neural development and synaptic signaling","description":"This cluster shows enrichment for terms tied to neural development and synaptic function: brain development, excitatory postsynaptic potential, Robo signaling, Rap signal transduction, and actin filament branching, which support neurite outgrowth and synaptic connectivity. Some terms (hair follicle morphogenesis, xenobiotic response) are divergent, but the dominant pattern centers on neuronal development and signaling. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031069","count":2},{"id":"GO:0050919","count":2},{"id":"GO:0090316","count":2},{"id":"GO:0090135","count":2},{"id":"GO:0032486","count":2}]},{"hash":"1018093146956788564","title":"Axon guidance and dendrite morphogenesis","description":"The top GO terms cluster around neuronal development and synaptic signaling: excitatory postsynaptic potentials, Robo (Roundabout) signaling, ephrin receptor signaling, and dendrite morphogenesis, with hedgehog-related signaling also implicated in development. Obsolete terms for actin remodeling and MAPK activation appear but do not overwhelm the neural theme, supporting a label focused on neural wiring and dendritic formation.","confidence":"High","size":6,"edges":5,"triangles":1,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0048013","count":4},{"id":"GO:0031532","count":4}]},{"hash":"2079678884376404756","title":"Glutamatergic synaptic signaling and plasticity","description":"This cluster is anchored by GO terms for glutamate receptor signaling, excitatory postsynaptic potentials, long-term synaptic depression, and calcium ion transport, pointing to proteins involved in excitatory synaptic transmission and synaptic plasticity. Some terms (e.g., startle response, dopamine metabolism) reflect broader neuronal signaling rather than core glutamatergic function, and one term (osteoclast proliferation) may be noise. Overall, the theme is consistent with glutamatergic synapse function and plasticity.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":2},{"id":"GO:0043278","count":2},{"id":"GO:0035725","count":1},{"id":"GO:0035235","count":1},{"id":"GO:0001964","count":1}]},{"hash":"2141983305605030284","title":"Retroviral integration and proviral latency","description":"The top GO terms cluster around retroviral life cycle steps: reverse transcription (RNA-templated DNA biosynthetic process), DNA integration, establishment of integrated proviral latency, and viral entry into the host nucleus, with related DNA recombination/replication processes. Some terms also touch on host-symbiont interactions, but the dominant signal is proviral integration and latency in the host genome. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0046718","count":3}]},{"hash":"2194101442694709823","title":"Proviral integration and retrotransposition","description":"The top terms point to viral genome integration into the host and mobile genetic elements: viral penetration into the nucleus, DNA integration, retrotransposition, DNA transposition, and DNA-templated transcription, including establishment of integrated proviral latency. Additional terms about symbiont entry and regulation of host signaling (NF-kappaB) reflect host-pathogen interactions and immune modulation during infection. Together, they describe a cluster centered on genome mobility elements and proviral/retrotransposon activity with host response components.","confidence":"High","size":6,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0075732","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0032197","count":2},{"id":"GO:0043124","count":2},{"id":"GO:0046718","count":2}]},{"hash":"2082321523108399003","title":"Embryonic and tissue development","description":"The cluster's top GO terms center on development across several tissues (thymus, placenta, cerebellar cortex, and muscle regeneration), suggesting a broad developmental/differentiation theme across organs. Some terms related to neural activity and stress responses may reflect maturation processes or context-specific regulation but do not overpower the overarching developmental signal.","confidence":"Medium","size":6,"edges":8,"triangles":5,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0048538","count":6},{"id":"GO:0071276","count":6},{"id":"GO:0001890","count":6},{"id":"GO:0000187","count":6},{"id":"GO:0090648","count":5}]},{"hash":"2224783963977936324","title":"Neural development and axon guidance","description":"This cluster centers on neuronal patterning and wiring, with GO terms for Hedgehog signaling (Smoothened), Slit-Robo signaling, and multiple axon guidance and sensory nerve development terms (olfactory bulb, trigeminal nerve, principal sensory nucleus). The presence of cell adhesion and vascular chemotaxis to FGF broadens to developmental signaling, but the dominant theme is neural development and axon pathfinding.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007224","count":2},{"id":"GO:0021772","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0007156","count":2},{"id":"GO:2000546","count":2}]},{"hash":"1536377999275723146","title":"Protein Processing and Maturation","description":"These proteins show several GO terms centered on proteolytic processing and maturation (islet amyloid polypeptide processing, protein autoprocessing, nerve growth factor processing), with additional terms touching on development and activation states (left/right symmetry, sperm capacitation). This suggests a theme around protein maturation/activation rather than a single signaling pathway, justifying the label Protein Processing and Maturation. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048240","count":2},{"id":"GO:0035025","count":2},{"id":"GO:0034231","count":1},{"id":"GO:0032805","count":1},{"id":"GO:0016540","count":1}]},{"hash":"931375930163425915","title":"Inflammation and ECM Remodeling","description":"The cluster includes immune-related terms (acute inflammatory response, positive regulation of cytokine production, immunological synapse formation, and negative regulation of Th17 lineage) alongside extracellular matrix and morphogenesis terms (fibronectin fibril organization, epithelial-to-mesenchymal transition, placental branching morphogenesis). This points to proteins involved in inflammatory signaling coupled with tissue remodeling/ECM dynamics, though a few terms (like foam cell differentiation and protein deamination) are less central to the core theme. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000329","count":2},{"id":"GO:0001771","count":2},{"id":"GO:0043277","count":2},{"id":"GO:0001837","count":2},{"id":"GO:1900017","count":2}]},{"hash":"1903163987261315545","title":"Protein acetylation and polyamine metabolism","description":"The GO terms are dominated by post-translational modification activities (peptidyl-lysine N6-acetylation, N-terminal propionylation, putrescine acetylation) and polyamine catabolic processes (putrescine and spermine). This points to a core theme of protein modification plus polyamine turnover, with additional metabolism and biosynthesis terms that fit a broader metabolic context. Confidence: Medium","confidence":"","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0018003","count":6},{"id":"GO:0060358","count":5},{"id":"GO:0046208","count":5},{"id":"GO:0006041","count":5},{"id":"GO:0009447","count":5}]},{"hash":"184848194037634186","title":"Cell migration and cytoskeleton signaling","description":"These proteins show a coherent theme around cell movement and cytoskeletal regulation, highlighted by cell migration and Rho signaling terms. While other annotations like mRNA processing and telomere maintenance appear, they likely reflect multifunctional proteins or annotation noise rather than a shared core function. Overall, the cluster centers on motility and cytoskeletal dynamics.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0035994","count":3},{"id":"GO:0045444","count":3},{"id":"GO:1904355","count":3}]},{"hash":"599777726446065987","title":"Retroviral integration and latency","description":"GO terms indicate a focus on retroviral life-cycle steps: RNA-templated DNA synthesis, DNA integration and recombination, DNA replication, viral entry into the host nucleus, and establishment of proviral latency, with related host defense and virus-host interaction signals. This pattern supports a label centered on retroviral integration and latency within host cells.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006278","count":4},{"id":"GO:1903704","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0006310","count":4}]},{"hash":"1011983144439698071","title":"Unknown","description":"The top GO terms pull from diverse domains (glucocorticoid signaling, auxin transport, neuroblast polarity, lung development, root meristem growth, centriolar localization, cytokinin signaling, telomerase assembly, and hypoxia response) with no single unifying function, and there are no reported edges among the proteins, so a cohesive functional label cannot be inferred.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042921","count":2},{"id":"GO:2000012","count":1},{"id":"GO:0045201","count":1},{"id":"GO:0060430","count":1},{"id":"GO:0010449","count":1}]},{"hash":"1438177252547597325","title":"Mitotic cell cycle regulation and checkpoints","description":"The cluster is enriched for terms governing progression through mitosis (G1/S and G2/M transitions), mitotic checkpoint signaling, and regulation of cell proliferation, indicating a cohesive role in cell-cycle control. Some additional terms relate to general stress responses, but the dominant theme is mitotic regulation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000082","count":2},{"id":"GO:0030097","count":2},{"id":"GO:0031571","count":2},{"id":"GO:0046827","count":2},{"id":"GO:0008285","count":2}]},{"hash":"200369249676145236","title":"Unknown","description":"The GO terms are highly diverse (DNA metabolism, xenobiotic response, cAMP signaling, corneocyte development, lipid signaling) with several obsolete entries, showing no clear, single function tying the proteins together. This makes it hard to assign a concise, representative label. Therefore, the cluster appears to reflect heterogeneous, unrelated roles rather than a cohesive pathway.","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006308","count":1},{"id":"GO:0042493","count":1},{"id":"GO:0090502","count":1},{"id":"GO:0071320","count":1},{"id":"GO:0003335","count":1}]},{"hash":"1669538686925270718","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0000185","count":3},{"id":"GO:0007014","count":3},{"id":"GO:0007026","count":3},{"id":"GO:0033151","count":3},{"id":"GO:0035372","count":3}]},{"hash":"1785801548506399149","title":"Neuronal excitability and ion homeostasis","description":"The GO terms point mainly to neuronal signaling and ion regulation: action potential and EPSP indicate excitability, receptor clustering suggests synaptic organization, and calcium and potassium ion handling reflect core ion channel function essential for signaling. Some terms also touch on circadian regulation and cardiac repolarization, which can involve electrophysiological processes, but the strongest signal is neuronal signaling and ion homeostasis. This cluster most plausibly represents proteins involved in shaping neuronal activity and ion balance.","confidence":"Medium","size":6,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0019228","count":1},{"id":"GO:0060453","count":1},{"id":"GO:0060307","count":1},{"id":"GO:0030007","count":1}]},{"hash":"1752500742446850663","title":"HRGP glycosylation and AGP biosynthesis","description":"The top terms cluster around hydroxyproline-linked O-glycosylation, arabinogalactan protein metabolism, and related mucilage/seed coat biosynthesis processes in plants, with some epidermal development references. This suggests a group of plant cell wall glycoproteins (HRGPs/AGPs) and their glycosylation pathways as the core function, even though a few terms are from other contexts. Confidence: Medium","confidence":"","size":6,"edges":10,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0018258","count":2},{"id":"GO:0042248","count":2},{"id":"GO:0048354","count":2},{"id":"GO:0010493","count":2},{"id":"GO:0010405","count":2}]},{"hash":"2292376785191892650","title":"Innate Immune Response and Interferon Signaling","description":"The top GO terms are strongly centered on innate immunity and interferon-beta\u2013related cellular responses, such as innate immune response and cellular response to interferon-beta, which provides a coherent functional theme for this cluster. The presence of ribosome biogenesis and translation terms appears ancillary, likely reflecting general cellular activity rather than a core ribosome-specific function, so the primary theme remains immune signaling.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0035458","count":2},{"id":"GO:0090529","count":2},{"id":"GO:0006400","count":2},{"id":"GO:0042254","count":2}]},{"hash":"1453740109246298175","title":"Proviral integration and latency","description":"The GO terms center on reverse transcription (RNA-templated DNA biosynthesis), DNA integration/recombination/replication, and specifically proviral latency, plus viral entry into host cells. This points to a retroviral life cycle with genome integration and maintenance as a latent provirus, rather than unrelated DNA processing. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006278","count":3},{"id":"GO:1903704","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0006310","count":3}]},{"hash":"1790667413097446129","title":"Vertebrate development and organogenesis","description":"These proteins cluster around vertebrate embryonic development and tissue formation, as shown by GO terms for mesoderm development, endocardial cushion EMT, roof of mouth development, and hair follicle morphogenesis, plus pancreatic endocrine and endocrine system development. While there are a few core cellular processes (RNA processing) present, the dominant themes point to organ formation and lineage specification in vertebrates, supporting a label centered on development and organogenesis.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":2},{"id":"GO:0031069","count":1},{"id":"GO:1903026","count":1},{"id":"GO:0003198","count":1},{"id":"GO:0060021","count":1}]},{"hash":"550526607952123567","title":"Regulation of gene expression and signaling","description":"These proteins appear connected by broad regulatory roles rather than a single molecular function: several GO terms indicate epigenetic regulation (histone modification, imprinting) and modulation of signaling pathways (lipopolysaccharide signaling, IGF receptor signaling, macrophage cytokine production), with additional notes on regulation of sodium ion transport and ubiquitination-related cytoskeletal processes. The absence of direct interactions supports a diverse, regulator-focused cluster rather than a cohesive complex.","confidence":"Low","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002028","count":1},{"id":"GO:0043045","count":1},{"id":"GO:0071641","count":1},{"id":"GO:0036353","count":1},{"id":"GO:0031664","count":1}]},{"hash":"949793701458679467","title":"Chitin and cell wall remodeling","description":"This cluster\u2019s terms predominantly relate to breakdown and restructuring of cell wall components: chitin catabolic process, peptidoglycan catabolic process, cellular response to chitin, and cell wall organization. A few terms (interferon-beta production, sperm development) appear tangential in this small set, but the strongest cohesive theme is chitin- and cell wall\u2013related remodeling.","confidence":"Low","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032608","count":1},{"id":"GO:0007291","count":1},{"id":"GO:0050910","count":1},{"id":"GO:0007288","count":1},{"id":"GO:1902083","count":1}]},{"hash":"1305990365661115896","title":"Unknown","description":"The GO terms for these six proteins cover a wide range of unrelated processes\u2014from protein ubiquitination and mitochondrial ribosome assembly to hormonal signaling, placental development, immune regulation, keratinocyte differentiation, phospholipid biosynthesis, and receptor clustering\u2014with no clear unifying function. Because there isn\u2019t a cohesive theme tying the proteins together, the cluster is best labeled Unknown, with no confidence in a shared function.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":1},{"id":"GO:0061668","count":1},{"id":"GO:0097211","count":1},{"id":"GO:0042730","count":1},{"id":"GO:0060672","count":1}]},{"hash":"2250344983353580039","title":"RNA processing and translation regulation","description":"The GO terms point to RNA metabolism and control of gene expression at multiple stages: splicing via spliceosome, mRNA export from the nucleus, regulation of mRNA stability in response to stress, eIF4F complex assembly, and miRNA/ncRNA-mediated silencing. While metal ion homeostasis terms appear, the dominant signals are RNA processing and translational regulation, suggesting these proteins function together in RNA maturation, export, stability, and translation control.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030026","count":1},{"id":"GO:0010960","count":1},{"id":"GO:0048026","count":1},{"id":"GO:0075525","count":1},{"id":"GO:0035278","count":1}]},{"hash":"125805510477705423","title":"Regulation of gene expression and development","description":"These GO terms cluster around regulation of RNA processing and gene expression (splicing, poly(A) tail regulation, miRNA silencing) and developmental signaling and differentiation (Wnt signaling, oocyte maturation, spermatid nucleus differentiation, eye development). While not all terms point to a single pathway, the cohesive theme is regulation of gene expression in developmental contexts, with DNA replication reflecting a cell-cycle related background. Confidence: Medium","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0033160","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0048026","count":1},{"id":"GO:0060212","count":1},{"id":"GO:0035413","count":1}]},{"hash":"2171242435103306942","title":"DNA Replication Stress Response and Repair","description":"The GO terms cluster around DNA replication and multiple repair pathways activated during replication stress (hydroxyurea response, SOS response, transcription-coupled NER, replication-born DSB repair via sister chromatid exchange) plus chromatin remodeling and telomere-associated fork processing. This combination suggests a functional module that maintains genome integrity during replication challenges.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0072711","count":3},{"id":"GO:0009432","count":2},{"id":"GO:0043044","count":2},{"id":"GO:0006283","count":2}]},{"hash":"506898738988542074","title":"Post-transcriptional RNA processing and translation control","description":"Enrichment includes splicing regulation (spliceosome and alternative splicing), mRNA export, and stress-related mRNA stability, along with ncRNA/miRNA-mediated silencing and translation initiation factor assembly, indicating a cohesive role in RNA maturation, export, surveillance, and translational regulation.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":4},{"id":"GO:0075525","count":4},{"id":"GO:0035278","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0006406","count":4}]},{"hash":"897429184682312372","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0042273","count":3},{"id":"GO:1903608","count":3},{"id":"GO:0000378","count":2}]},{"hash":"622566023129853379","title":"Ubiquitin-Dependent Proteolysis and JNK Signaling","description":"Dominated by ubiquitin-dependent protein catabolic processes (including autoubiquitination and K63-linked ubiquitination) and associated trafficking pathways, with links to regulation of the JNK cascade and apoptosis. The common thread is ubiquitin-mediated proteolysis shaping signaling and cell fate.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0051865","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0060669","count":2},{"id":"GO:0043162","count":2}]},{"hash":"270350023747394532","title":"Amino acid metabolism and sulfur compound biosynthesis","description":"The cluster contains GO terms spanning biosynthesis (tryptophan, isoleucine) and catabolism (serine, homocysteine, amine), plus hydrogen sulfide biosynthesis and coenzyme M biosynthesis, indicating a common theme of amino acid and sulfur compound metabolism.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009097","count":1},{"id":"GO:0000162","count":1},{"id":"GO:0006565","count":1},{"id":"GO:0043418","count":1},{"id":"GO:0019295","count":1}]},{"hash":"296435412633866421","title":"Viral life cycle proteins","description":"The top GO terms are dominated by stages of the viral life cycle\u2014symbiont entry into host, virion assembly, viral release, and proviral latency\u2014suggesting these proteins are implicated in viral infection and replication. Additional terms reflect host\u2013virus interactions (polyubiquitination, signaling) and broad cellular processes, which is common in viral lifecycle regulation. Overall, the strongest signal is viral entry, assembly, and latency, supporting a label centered on viral life cycle functions.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":2},{"id":"GO:0030260","count":2},{"id":"GO:0019068","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0071560","count":2}]},{"hash":"1263915474993354656","title":"Imaginal Disc Development and Transcription Regulation","description":"The top GO terms cluster around imaginal disc development in Drosophila (eye-antennal disc development; imaginal disc growth) and transcriptional regulation by RNA Pol II (promoter opening, initiation, snRNA transcription), with links to actin cytoskeleton\u2013mediated morphogenesis. A viral process term appears but doesn\u2019t define the group; overall, these proteins seem tied to developmental transcription control and morphogenesis in imaginal discs.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":2},{"id":"GO:0035214","count":1},{"id":"GO:0007000","count":1},{"id":"GO:0045572","count":1},{"id":"GO:0006355","count":1}]},{"hash":"317723650608533842","title":"Ribosome biogenesis and translation","description":"Reasoning: The top terms cluster around core gene expression processes\u2014translation, ribosome-related RNA processing (LSU rRNA maturation), mRNA capping, tRNA modification, and co-translational protein modification\u2014indicating a shared theme of protein synthesis machinery. Some viral and autophagy-related terms appear as outliers, but the dominant signal is ribosome assembly and translation. ","confidence":"High","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0070584","count":2},{"id":"GO:0043686","count":1},{"id":"GO:0031365","count":1},{"id":"GO:0002128","count":1}]},{"hash":"1242992312308507663","title":"Stress-responsive protein quality control and RNA regulation","description":"This cluster brings together translation, protein ubiquitination/ERAD, and stress-related mRNA stability regulation, along with peroxisomal protein import and signaling regulation. These themes collectively point to cellular stress response and protein homeostasis pathways, with a couple of outliers (developmental and host-viral interaction terms) that are less central to the core theme.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0023051","count":1},{"id":"GO:2000627","count":1},{"id":"GO:0010323","count":1},{"id":"GO:0022013","count":1}]},{"hash":"2280775300294500043","title":"Translation machinery and ribosome biogenesis","description":"The proteins show strong enrichment for translation-related processes: cytosolic and mitochondrial translation, translational initiation and termination, ribosomal large subunit assembly, and rRNA maturation, pointing to roles in the protein synthesis machinery. A few terms suggest regulatory responses to stress (UV, gamma radiation) that can modulate translation, but the core theme remains translation and ribosome assembly.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:1901194","count":1},{"id":"GO:0006413","count":1},{"id":"GO:0000462","count":1},{"id":"GO:0001649","count":1}]},{"hash":"175283120451980060","title":"Microtubule-guided cell division and neuronal transport","description":"The terms point to microtubule-based organization and movement across contexts: spindle assembly and chromosome dynamics in mitosis, nuclear migration along microtubules, plus-end directed microtubule sliding, and dendritic transport of receptor complexes, with cerebellar layer structural organization reflecting neuronal cytoskeleton roles. This suggests a cohesive theme around microtubule-driven cellular architecture and transport.","confidence":"Medium","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0021685","count":2},{"id":"GO:0000742","count":2},{"id":"GO:0051255","count":2},{"id":"GO:0030473","count":2},{"id":"GO:0000073","count":2}]},{"hash":"688681910121125273","title":"Ribosome biogenesis and rRNA maturation","description":"The dominant GO terms are about ribosome biogenesis, cytosolic and preribosome assembly, and maturation/processing of rRNA, pointing to a shared role in ribosome formation. Some additional terms reference RNA modification (methylation) and translation, which fit within the broader ribosome/translation pathway. Overall, the cluster appears to encode proteins involved in ribosome assembly and rRNA maturation rather than unrelated processes.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070131","count":1},{"id":"GO:0070475","count":1},{"id":"GO:0042254","count":1},{"id":"GO:0000463","count":1},{"id":"GO:1902626","count":1}]},{"hash":"171099160504692381","title":"Mitochondrial energy metabolism and purine catabolism","description":"This cluster is dominated by GO terms tied to mitochondrial electron transport and ATP synthesis, indicating a core theme of energy production. The presence of xanthine and hypoxanthine catabolic processes further supports a link to purine metabolism. The other terms (response to aluminum ion, various signaling and developmental regulations, and abscisic acid biosynthesis) appear less connected and may reflect broader or pleiotropic annotations rather than a single cohesive function for these proteins. Overall, the strongest shared biology points to mitochondrial energy production and purine catabolism.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006122","count":1},{"id":"GO:0042776","count":1},{"id":"GO:0009115","count":1},{"id":"GO:0010044","count":1},{"id":"GO:0051898","count":1}]},{"hash":"488263031435843829","title":"Autophagy and Cofactor Biosynthesis","description":"The proteins show strong autophagy-related GO terms (macroautophagy, piecemeal microautophagy of the nucleus, autophagy of mitochondrion) together with biosynthetic/cofactor pathways (molybdenum cofactor and thiamine biosynthesis). This points to a cluster centered on autophagy-linked maintenance of organelle quality and metabolism rather than a single, narrow function.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006777","count":4},{"id":"GO:0051726","count":4},{"id":"GO:0016236","count":4},{"id":"GO:0009228","count":4},{"id":"GO:0034727","count":4}]},{"hash":"2178636178926943136","title":"Unknown","description":"The terms span polyamine catabolism, general metabolism (glucosamine, acetylation), a post-translational modification (propionylation), and various development or regulatory processes (angiogenesis, leaf formation, melatonin synthesis, heterochromatin formation) across different contexts. There isn't a single cohesive function linking these proteins, so a concise, accurate label is not apparent.","confidence":"","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060358","count":2},{"id":"GO:0046208","count":2},{"id":"GO:0006041","count":2},{"id":"GO:0009447","count":2},{"id":"GO:0061606","count":2}]},{"hash":"2110496546535696183","title":"Immune Activation and Organ Development","description":"The top GO terms show immune-related activities (complement activation, lectin pathway; basophil and platelet activation; phagocytosis recognition; NK cell chemotaxis regulation) together with developmental processes (cartilage condensation; mesonephric duct development; metanephric proximal/distal tubule morphogenesis). This suggests the cluster comprises proteins with roles in both immune signaling and organ development, pointing to multi-functional involvement in tissue morphogenesis and immune responses.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090238","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0006910","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0072177","count":2}]},{"hash":"417456246771128619","title":"Mitochondrial Complex I/IV Assembly and Import","description":"The top GO terms are centered on mitochondrial biogenesis: assembly of respiratory chain complexes I and IV and import of proteins into the mitochondrial matrix. Although there are several development-related terms in the list, the strongest, recurring theme is mitochondrial assembly and import, suggesting the cluster mainly reflects mitochondrial biogenesis functions.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":1},{"id":"GO:0030150","count":1},{"id":"GO:0090351","count":1},{"id":"GO:0032981","count":1},{"id":"GO:0007386","count":1}]},{"hash":"80085549378611574","title":"DNA/RNA metabolism and genome integration","description":"The top GO terms point to DNA repair, replication and recombination activities (DNA strand displacement; regulation of sister chromatid segregation; maintenance of rDNA; negative regulation of DSB repair via HR), plus RNA-templated DNA biosynthesis and DNA integration, and even retroviral-related processes (establishment of integrated proviral latency). There is also a tRNA modification term, suggesting broader RNA processing. A single term about pollen development seems unrelated noise. Taken together, the cluster appears to reflect genome maintenance and RNA/DNA metabolism with potential retrotransposon or provirus\u2013like activities, rather than a single, cohesive pathway.","confidence":"Low","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009555","count":1},{"id":"GO:0033045","count":1},{"id":"GO:0043007","count":1},{"id":"GO:0000732","count":1},{"id":"GO:2000042","count":1}]},{"hash":"1558041232091331644","title":"Amino acid and thiamine biosynthesis with redox balance","description":"This cluster is enriched in biosynthetic processes for amino acids and cofactors (glutamate, beta-alanine, thiamine) and redox-related terms (cellular redox homeostasis, response to oxygen radicals), along with related metabolic activities like nitrate assimilation and mercury detoxification, suggesting a metabolism- and redox-focused module. Some terms (gastrulation, obsolete aging) appear to be annotation noise.","confidence":"Medium","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0097054","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0009228","count":2},{"id":"GO:0050787","count":2}]},{"hash":"1685266717024399254","title":"Ubiquitin-Proteasome Regulation","description":"Most of the top GO terms are about ubiquitination and SCF-dependent proteasomal degradation (polyubiquitination, proteasome-dependent protein catabolic process, and regulation of ubiquitin ligase activity), indicating a core function in protein turnover and proteostasis. The developmental terms likely reflect context-specific roles in certain tissues, but the dominant theme is ubiquitin-mediated proteolysis.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0031146","count":2},{"id":"GO:2001162","count":1},{"id":"GO:1904668","count":1}]},{"hash":"994844626863742389","title":"Developmental Transcriptional Regulation","description":"The top GO terms point to transcriptional control (DNA-templated transcription, negative regulation of transcription by RNA Pol II, preinitiation complex assembly) along with a broad range of developmental and morphogenetic processes across different tissues (pancreas, gonad, neural crest migration, ureteric morphogenesis, digestive tract, skeletal muscle, trachea cartilage). This pattern suggests a cluster of proteins involved in regulating gene expression during embryonic development across multiple lineages rather than a single tissue-specific function.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0031018","count":4},{"id":"GO:0000122","count":3},{"id":"GO:2000020","count":3},{"id":"GO:0001755","count":3}]},{"hash":"1554085571468076043","title":"Mitochondrial Translation and Respiratory Chain Assembly","description":"This cluster shows translation-related activity together with mitochondrial electron transport and Complex II assembly, suggesting a functional grouping around mitochondrial protein synthesis and the maintenance/assembly of respiratory chain complexes. The combination points to a mitochondria-centered theme, though the translation term is broad, so this label is a best-fit rather than definitive. ","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0034553","count":1},{"id":"GO:0006120","count":1}]},{"hash":"1332897112120453713","title":"Cell Cycle and Ubiquitination Regulation","description":"The top GO terms cluster around mitotic cell cycle activities (mitosis, meiosis-related chromosome alignment, cytokinesis) and regulation of ubiquitination (K48-linked and monoubiquitination), pointing to a shared function in controlling cell division and protein turnover. Some terms also reference apoptosis regulation and developmental contexts (placental layer development), which may reflect broader roles in development linked to cell cycle and ubiquitin signaling. Overall, the core theme appears to be coordination of cell division and ubiquitin-mediated regulation of proteins, with auxiliary developmental associations.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0060712","count":1},{"id":"GO:1902524","count":1},{"id":"GO:2001271","count":1},{"id":"GO:0051311","count":1}]},{"hash":"864523855630001550","title":"Unknown","description":"The top GO terms are highly diverse, covering DNA replication and cell cycle, innate immune responses, neural development, muscle regeneration, extracellular matrix regulation, and other unrelated processes. This lack of a single coherent biological theme among the frequent terms suggests there isn\u2019t a clear, shared function defining this cluster. None","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0045087","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0090648","count":3},{"id":"GO:0021695","count":3}]},{"hash":"1948209480128217269","title":"Synaptic vesicle trafficking and endosomal signaling","description":"The cluster centers on neuronal vesicle biology: regulation of synaptic vesicle exocytosis, vesicle fusion, endosome localization, Rab signaling, and plasticity-related pathways (e.g., long-term potentiation, reelin signaling). While a couple terms (e.g., mating projection growth, macrophage cytokine regulation) are less directly tied to neurons, the dominant theme is neuronal vesicle trafficking and synaptic signaling.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010796","count":2},{"id":"GO:2000300","count":2},{"id":"GO:0036010","count":2},{"id":"GO:0031384","count":2},{"id":"GO:0010936","count":2}]},{"hash":"1153190967220493248","title":"Chromatin regulation and transcription control","description":"The top GO terms cluster around chromatin and transcription regulation, including negative regulation of transcription by RNA polymerase I, peptidyl-lysine deacetylation, and heterochromatin-related processes, pointing to a chromatin remodeling/transcription control core. A few outlier terms (mitophagy, angiogenesis, plant defense) suggest broader regulatory roles but do not overshadow the central chromatin theme. ","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0016479","count":5},{"id":"GO:0048742","count":5},{"id":"GO:0009861","count":5},{"id":"GO:0010978","count":5},{"id":"GO:0016584","count":5}]},{"hash":"1636549550381535187","title":"Developmental chromatin regulation and mitosis","description":"The top GO terms include spindle assembly (mitosis) and various chromatin modification processes (histone acetylation/methylation, DNA methylation/heterochromatin formation) alongside several developmental processes (neural and germline development). This suggests a theme of chromatin dynamics linked to developmental programs and cell division, even though a few terms are less cohesively related. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":2},{"id":"GO:0090309","count":2},{"id":"GO:0030901","count":2},{"id":"GO:0097190","count":2},{"id":"GO:0002509","count":2}]},{"hash":"1309331877290557978","title":"COPII vesicle trafficking and epithelial polarity","description":"The Top Terms cluster centers on COPII vesicle coating regulation and ER-to-Golgi transport, with accompanying terms for epithelial apical/basal polarity and related secretory processes. Some terms also touch hepatocyte signaling and vascular morphogenesis, suggesting a cohesive theme around vesicle trafficking integrated with tissue organization.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0003400","count":2},{"id":"GO:0035729","count":2},{"id":"GO:0060982","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0061156","count":2}]},{"hash":"1874445483149226066","title":"Cell signaling in proliferation and neural differentiation","description":"This cluster features GO terms spanning immune signaling (T cell receptor pathway), metabolic signaling (insulin receptor pathway), and neural development and regeneration (cerebellar cortex formation, Bergmann glial differentiation, axon regeneration), along with regulation of cell proliferation. The common thread appears to be signaling pathways that govern cell growth, differentiation, and maturation across multiple cell types, including neural lineages. While the terms are diverse, they collectively point to a theme of signaling-controlled proliferation and neural differentiation.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0050852","count":5},{"id":"GO:0021697","count":5},{"id":"GO:0008285","count":5},{"id":"GO:0060020","count":5},{"id":"GO:0048679","count":5}]},{"hash":"1725674180801558705","title":"Cytoskeletal dynamics and cell polarity","description":"This cluster centers on cytoskeletal organization and related cellular architecture, with GO terms for actin filament bundle assembly, spindle assembly, and establishment of epithelial cell polarity, plus a few related cytoskeletal/trafficking processes. While some terms are peripheral, the dominant signal points to cytoskeletal remodeling and polarity maintenance as the shared theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":2},{"id":"GO:0051225","count":1},{"id":"GO:0035994","count":1},{"id":"GO:0035544","count":1},{"id":"GO:0051017","count":1}]},{"hash":"2126158983841232186","title":"Unknown","description":"The top GO terms span several unrelated processes (dsRNA-induced cellular response, photosynthesis, cadmium response, and various obsolete regulatory processes) with no clear common function tying the proteins together. The absence of edges and cohesive annotations suggests there is no interpretable, shared biological role for this cluster. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071360","count":2},{"id":"GO:1903646","count":2},{"id":"GO:0051348","count":2},{"id":"GO:1902391","count":2},{"id":"GO:2001162","count":2}]},{"hash":"2004495304719859545","title":"Genome integrity and transcription control","description":"The annotations center on transcription regulation and genome maintenance\u2014negative regulation of RNA Pol II, transcriptional fidelity (Pol III), piRNA processing, and mismatch repair\u2014suggesting a shared role in genome integrity. A few terms (TLR2 signaling, otic placode formation) seem less related and may reflect annotation noise.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0034137","count":1},{"id":"GO:0034587","count":1},{"id":"GO:0043049","count":1},{"id":"GO:0044334","count":1}]},{"hash":"1325846287414525772","title":"Neural development and axon guidance","description":"The top GO terms cluster around nervous system development: retina layer formation, retina vasculature morphogenesis, neural crest cell migration, sympathetic ganglion development, commissural neuron axon guidance, and paranodal junction assembly, with an additional cue from regulation of synaptic vesicle endocytosis. This points to proteins involved in neural development and axon pathfinding, with related synaptic maintenance roles, making this label representative of the cluster\u2019s function.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":4},{"id":"GO:0010842","count":4},{"id":"GO:0006469","count":3},{"id":"GO:1902378","count":2},{"id":"GO:0036486","count":2}]},{"hash":"2040032569337620413","title":"Plant stress response and signaling","description":"Terms point to plant-specific stress responses (cadmium, unfolded protein, hydrogen peroxide) and hormone signaling (cytokinin), with photosynthesis indicating a plant context; together they suggest a cluster of plant stress signaling and protein homeostasis.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:1903646","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0015979","count":3},{"id":"GO:1903070","count":3},{"id":"GO:0009736","count":3}]},{"hash":"2213565292464243775","title":"Cerebellar development and synaptic assembly","description":"The cluster shows strong representation of cerebellum-related processes: cerebellar cortex formation, Bergmann glial differentiation, and postsynaptic density assembly, along with axon regeneration and regulation of signaling pathways (e.g., PI3K/AKT, protein dephosphorylation). Although one term involves T cell receptor signaling, the dominant theme is neural development and synaptic organization in the cerebellum with modulation of growth and signaling. This makes \"Cerebellar development and synaptic assembly\" a concise, representative label.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":3},{"id":"GO:0021697","count":3},{"id":"GO:0097107","count":3},{"id":"GO:0051895","count":3},{"id":"GO:0008285","count":3}]},{"hash":"552544662662731516","title":"Unknown","description":"The GO terms are a mix of immune signaling (T cell receptor pathway), sperm axoneme assembly, neuron projection development, meiotic telomere clustering, and various DNA damage response processes (DNA repair, checkpoint signaling, and translesion synthesis). This scattered set lacks a single cohesive function, so a concise, representative label cannot be determined.","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0050852","count":5},{"id":"GO:0090089","count":5},{"id":"GO:0007288","count":5},{"id":"GO:0045739","count":5},{"id":"GO:0010976","count":5}]},{"hash":"1993210085393647692","title":"Angiogenic signaling and endothelial migration","description":"The top GO terms are dominated by angiogenesis and positive regulation of endothelial cell migration, with supporting ERK1/2 cascade regulation, pointing to a module centered on vascular development and signaling that promotes blood vessel formation. Outliers like piRNA processing and mismatch repair likely reflect multifunctional proteins or noise rather than core function. Overall, the core theme is angiogenic signaling and endothelial dynamics.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0051968","count":2},{"id":"GO:0043536","count":2},{"id":"GO:0050714","count":2}]},{"hash":"620610743968218542","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006805","count":3},{"id":"GO:0030210","count":3},{"id":"GO:0030205","count":3},{"id":"GO:0006477","count":3},{"id":"GO:0000103","count":3}]},{"hash":"1606566951369190695","title":"Unknown","description":"The top GO terms span plant development (secondary shoot formation), hormone biosynthesis (strigolactone biosynthetic process), and pigment/metabolic catabolism (chlorophyll, triglyceride, nitrogen utilization), plus detoxification and even xenobiotic catabolic processes, with no clear single functional theme linking the proteins. Since there are no interactions (edges) to reinforce a cohesive pathway and the terms are heterogeneous, a specific, representative label cannot be confidently assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0019260","count":2},{"id":"GO:0046272","count":2},{"id":"GO:0010223","count":2},{"id":"GO:0097755","count":2}]},{"hash":"1030112155090595402","title":"Glycosylation and carbohydrate biosynthesis","description":"The terms cluster around sugar metabolism (sucrose, starch, glycogen, sorbitol response) and glycosylation processes (GPI anchor biosynthesis; protein glycosylation), suggesting a theme of carbohydrate and glycoprotein biosynthesis, despite a few outliers (e.g., bacillithiol biosynthesis).","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072708","count":4},{"id":"GO:0019252","count":4},{"id":"GO:0005985","count":4},{"id":"GO:0097502","count":4},{"id":"GO:0005978","count":4}]},{"hash":"2133498402313143935","title":"Ion transport and calcium signaling","description":"This cluster centers on ion transport and calcium-related regulation: terms about calcium release/regulation, maintaining electrochemical gradients, ion homeostasis (potassium, copper, cadmium), and muscle contraction linked to calcium signaling. While one term (stilbene catabolic process) seems unrelated, the dominant theme is ions and calcium signaling across the proteins.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061454","count":1},{"id":"GO:0010248","count":1},{"id":"GO:0046272","count":1},{"id":"GO:0051481","count":1},{"id":"GO:1903249","count":1}]},{"hash":"1166012564223610387","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006805","count":4},{"id":"GO:0030210","count":4},{"id":"GO:0030205","count":4},{"id":"GO:0006477","count":4},{"id":"GO:0000103","count":4}]},{"hash":"1793650979282335830","title":"Unknown","description":"The listed GO terms span cell-matrix adhesion, nucleotide and steroid metabolism, phosphorylation cycles, and even antibiotic response, with no clear single functional theme binding the proteins. This lack of a cohesive function makes a precise, representative label untenable.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":2},{"id":"GO:0046085","count":1},{"id":"GO:0016310","count":1},{"id":"GO:0006195","count":1},{"id":"GO:0016311","count":1}]},{"hash":"2300405617356214300","title":"Glycosylation and carbohydrate biosynthesis","description":"The top GO terms point to glycosylation-related processes (GPI anchor biosynthesis, protein glycosylation in ER, mannosylation) alongside carbohydrate metabolism and biosynthesis (starch, glycogen, sucrose; response to sugars). This suggests a cluster centered on glycosylation and carbohydrate biosynthesis/metabolism, with DNA replication appearing incidental rather than core to the cluster\u2019s function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0072708","count":2},{"id":"GO:0019252","count":2},{"id":"GO:0005985","count":2},{"id":"GO:0097502","count":2}]},{"hash":"807356126359893393","title":"Neuronal development and actin dynamics","description":"This cluster shows brain development and excitatory synaptic potential terms, along with Rap signaling and actin filament branching, pointing to neuronal differentiation and synapse formation with cytoskeletal remodeling; hair follicle morphogenesis and xenobiotic response are present but less central.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903206","count":4},{"id":"GO:0031069","count":3},{"id":"GO:0050919","count":3},{"id":"GO:0090316","count":3},{"id":"GO:0090135","count":3}]},{"hash":"1106533693114209153","title":"Flavonoid and lignin biosynthesis","description":"This cluster is enriched for flavonoid-related biosynthesis (kaempferol and quercetin glycosides, anthocyanin-containing compounds) and lignin biosynthesis, plus cell wall organization. These together suggest a primary role in phenylpropanoid-derived secondary metabolism and cell wall assembly, with ancillary glycosylation processes. ","confidence":"Medium","size":5,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016999","count":2},{"id":"GO:0009808","count":2},{"id":"GO:0033330","count":2},{"id":"GO:0006488","count":2},{"id":"GO:0009718","count":2}]},{"hash":"874521311194521755","title":"Actin Cytoskeleton and Junction Organization","description":"The top GO terms point to actin-related processes (actin filament bundle assembly; actomyosin structure organization) and cell-cell junction organization, indicating a common theme of cytoskeletal remodeling and cell adhesion. While other terms span diverse developmental contexts (phloem/ectoderm development, thyroid hormone response), the strongest cohesive signal is cytoskeletal dynamics and junction organization, justifying this label.","confidence":"Medium","size":5,"edges":7,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010088","count":2},{"id":"GO:0090334","count":2},{"id":"GO:0045216","count":2},{"id":"GO:0060067","count":2},{"id":"GO:0010735","count":2}]},{"hash":"2221217881269560387","title":"Embryonic tissue morphogenesis","description":"The GO terms cluster around developmental processes across several tissues (neuronal differentiation, foregut morphogenesis, endocardial differentiation, digit morphogenesis), indicating a broad theme of embryonic tissue morphogenesis rather than a single specific pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060579","count":1},{"id":"GO:0045463","count":1},{"id":"GO:0019800","count":1},{"id":"GO:0042492","count":1},{"id":"GO:0001516","count":1}]},{"hash":"33906137200176603","title":"Nematode Molting and Pharyngeal Pumping","description":"The top GO terms point to nematode-specific biology: a molting cycle tied to collagen/cuticulin-based cuticle and nematode pharyngeal pumping. Together they suggest proteins involved in cuticle remodeling during molts and in feeding-related pharyngeal activity characteristic of nematodes, giving a coherent functional theme for the cluster. However, with only two terms and a small set of proteins, the assignment remains tentative.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":1},{"id":"GO:0043050","count":1}]},{"hash":"1778518772112414754","title":"Viral DNA integration and cell cycle control","description":"The cluster centers on DNA mobility and proviral states (DNA transposition, DNA integration, establishment of integrated proviral latency) and co-occurs with cell cycle and chromosome segregation terms, suggesting a theme of viral genome integration affecting host cell division. Additional terms about defense against virus and symbiont entry reinforce a virus\u2013host interaction context, though the core signal is integration-related and its impact on the cell cycle.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0006313","count":4},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0007049","count":3}]},{"hash":"2302100198347650379","title":"Unknown","description":"The top GO terms are eclectic, including plant-specific glycoprotein/glycosylation processes (arabinogalactan protein metabolism, mucilage/seed coat biosynthesis, hydroxyproline O-glycosylation) and unrelated insect development terms (egg chamber adhesion, insect visual primordium). There isn\u2019t a single cohesive biological function uniting these terms, suggesting noise or mixed functional annotation rather than a distinct cluster pathway.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":2},{"id":"GO:0018258","count":1},{"id":"GO:0042248","count":1},{"id":"GO:0048354","count":1},{"id":"GO:0010493","count":1}]},{"hash":"476916514646086502","title":"Osteogenesis and odontogenesis","description":"The GO terms show a strong emphasis on bone and tooth formation, including positive regulation of osteoblast differentiation, osteoblast fate commitment, osteoblast development, and regulation of odontogenesis. There is also support for stem cell differentiation and FGFR signaling involvement, which are all links to skeletal/dental tissue formation and lineage specification. Some immune differentiation terms exist but appear less central to the core theme. Overall, the cluster appears to center on bone and tooth development and associated stem-cell\u2013driven differentiation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901522","count":2},{"id":"GO:0042487","count":2},{"id":"GO:0045669","count":2},{"id":"GO:0002051","count":2},{"id":"GO:0030217","count":2}]},{"hash":"1772070619279403318","title":"SNARE-driven synaptic vesicle trafficking","description":"These terms cluster around Golgi-associated vesicle transport and SNARE-dependent exocytosis at synapses, including vesicle fusion, receptor insertion at the postsynaptic membrane, and processes linked to synaptic potentiation. The common theme is SNARE-mediated vesicle trafficking and fusion at the neuronal synapse.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0090161","count":5},{"id":"GO:0060291","count":4},{"id":"GO:0048280","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0035493","count":4}]},{"hash":"896420179241078033","title":"Actin Filament Assembly and Remodeling","description":"This cluster centers on actin cytoskeleton dynamics, with GO terms for actin filament polymerization, muscle thin filament assembly, and positive regulation of stress fiber assembly and ruffle formation, pointing to actin remodeling as a unifying theme. While a few terms touch on broader processes like oocyte transport or CNS remodeling, the dominant signal is cytoskeletal organization and actin-based assembly/remodeling. Confidence is based on the strongest overlap of terms being cytoskeletal; some terms may reflect broader or context-specific roles.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007300","count":1},{"id":"GO:0035193","count":1},{"id":"GO:0030845","count":1},{"id":"GO:0051497","count":1},{"id":"GO:0045944","count":1}]},{"hash":"539023528202403586","title":"Glutamatergic synaptic transmission regulation","description":"The majority of top GO terms point to glutamatergic synapses and excitatory signaling (excitatory postsynaptic potential, regulation of glutamatergic transmission, vesicle endocytosis), suggesting these proteins participate in glutamatergic synaptic signaling and vesicle trafficking; a couple of unrelated annotations exist, but the core theme is synaptic transmission.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":4},{"id":"GO:1900242","count":4},{"id":"GO:1903125","count":4},{"id":"GO:0099139","count":4},{"id":"GO:0090394","count":4}]},{"hash":"132385516667538522","title":"Neural crest migration and axon guidance","description":"The terms cluster around neural crest\u2013derived development and nervous system wiring: multiple items describe neural crest cell migration (ventral trunk, autonomic nervous system), sympathetic ganglion development, commissural neuron axon guidance, paranodal junction assembly, and neuron migration (including hypothalamic GnRH neurons). Additional terms point to craniofacial/ear development and retina vasculature morphogenesis, which often accompany neural crest\u2013driven tissues and neural connectivity. Together, these indicate a cohesive theme of neural crest\u2013driven development and axon guidance, with supporting vascular and craniofacial context.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030220","count":2},{"id":"GO:1902378","count":2},{"id":"GO:0036486","count":2},{"id":"GO:0061549","count":2},{"id":"GO:0061299","count":2}]},{"hash":"1233747811884213121","title":"Cardiac GPCR\u2013cAMP signaling and Ca2+ regulation","description":"GO terms emphasize GPCR signaling (adenosine and adrenergic receptors), activation of adenylate cyclase, cAMP-mediated signaling, calcium release, and heart development, together with protein phosphorylation. This points to a coherent GPCR-cAMP-Ca2+ signaling module relevant to cardiac biology.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030948","count":2},{"id":"GO:0043950","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0071880","count":2},{"id":"GO:0006468","count":2}]},{"hash":"2166288648364852407","title":"Embryonic and Neural Development","description":"The top GO terms cluster around neuron maturation, neural precursor proliferation, and in utero embryonic development, suggesting enrichment for neural differentiation and early development processes. While there are some metabolism-related terms, the strongest shared theme points to embryonic and neural development.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042551","count":3},{"id":"GO:0045654","count":3},{"id":"GO:0001701","count":3},{"id":"GO:0043046","count":3},{"id":"GO:0042128","count":2}]},{"hash":"1017276195619052265","title":"Unknown","description":"The cluster shows diverse terms across neuronal signaling, immune and inflammatory pathways, and development, with no single unifying function. Terms include excitatory postsynaptic potential, JNK cascade, PI3K/AKT regulation, NF-kappaB related activity, LPS signaling, muramyl dipeptide response, and development/proliferation terms. Because these functions do not converge on one clear biological theme, a concise, representative cluster name cannot be reliably assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":3},{"id":"GO:0051897","count":3},{"id":"GO:0060324","count":3},{"id":"GO:0033598","count":3},{"id":"GO:0031663","count":3}]},{"hash":"2118722106448436943","title":"Innate Immune and Stress Response","description":"The top GO terms point to innate immune sensing of microbial components (cellular response to fungal origin, response to lipopolysaccharide) and downstream activities like phagocytosis recognition and platelet-related inflammatory signaling, with additional notes on stress responses and cell adhesion regulation. This suggests a theme around innate immunity and cellular stress/inflammatory signaling, though the terms are somewhat diverse and the cluster shows limited connectivity, making the label tentative rather than definitive.","confidence":"Low","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":5},{"id":"GO:0010572","count":4},{"id":"GO:0032496","count":3},{"id":"GO:0032355","count":3},{"id":"GO:0071260","count":3}]},{"hash":"1157364315928409509","title":"Neuroendocrine Thermoregulation and Cardiovascular Signaling","description":"The top GO terms cluster around neural/endocrine control of physiology, with emphasis on temperature response and energy expenditure (cellular response to temperature stimulus, diet-induced thermogenesis), neuropeptide signaling, and vascular regulation (vasopressin-related blood pressure regulation, smooth muscle relaxation, dopamine uptake in synaptic transmission). This suggests a coherent theme of neuroendocrine/autonomic pathways coordinating thermoregulation, pain modulation, and cardiovascular tone, though a few inflammation-related terms are present as ancillary signals.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071502","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0043950","count":3},{"id":"GO:0032651","count":3}]},{"hash":"1453384770612953932","title":"Neuroendocrine Regulation of Vascular and Immune Signaling","description":"The terms cluster around neural signaling (neuropeptide signaling, dopamine uptake) and hormonally mediated vascular regulation (vasopressin- and renin-related pathways affecting blood pressure), with concurrent immune modulation (IL-1\u03b2 and chemokine production). This points to a cohesive theme of neuroendocrine control of vascular function coupled with immune signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043950","count":2},{"id":"GO:0032651","count":2},{"id":"GO:0007218","count":2},{"id":"GO:2000724","count":2},{"id":"GO:0090075","count":2}]},{"hash":"983898196050423928","title":"Unknown","description":"The GO terms span development (cartilage condensation; mesonephric duct development), immunity (cellular response to fungal origin; complement activation; phagocytosis), and signaling/regulation (JNK cascade, transcription factor activity, CDK activity). This lack of a single cohesive function or pathway makes it hard to assign a meaningful, concise label, so the cluster is Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":2},{"id":"GO:0071226","count":2},{"id":"GO:0046329","count":2},{"id":"GO:0032092","count":2},{"id":"GO:0043433","count":2}]},{"hash":"295579674233854305","title":"Unknown","description":"The listed GO terms span polyamine catabolism (spermine, putrescine), glucosamine metabolism, post-translational N-terminal propionylation, and additionally include unrelated processes such as angiogenesis, leaf formation, melatonin biosynthesis, and subtelomeric heterochromatin formation. This broad mix shows no coherent single function linking the five proteins, so a specific, representative cluster name cannot be inferred.","confidence":"","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060358","count":5},{"id":"GO:0046208","count":5},{"id":"GO:0006041","count":5},{"id":"GO:0009447","count":5},{"id":"GO:0061606","count":5}]},{"hash":"2297538620499936335","title":"Calcium and cAMP Signaling Regulation","description":"The top GO terms cluster around modulation of signaling pathways, notably calcium release, cAMP signaling via adenylate cyclase, and protein phosphorylation, with positive regulation of GTPase activity. These point to a common theme of signaling pathway regulation that can influence proliferation and development processes, even though some terms (visual perception, diet-induced thermogenesis, heart development) reflect downstream or tissue-specific contexts. Confidence: Medium","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043950","count":2},{"id":"GO:0071502","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0006468","count":2},{"id":"GO:0007507","count":2}]},{"hash":"323314586842319816","title":"Neuropeptide signaling and blood pressure regulation","description":"This cluster centers on neuropeptide signaling and neuroendocrine control of vascular function, highlighted by neuropeptide signaling, vasopressin- and renin-related regulation of blood pressure, and related dopamine signaling and muscle relaxation processes. While immune-related terms appear, the strongest linking theme is neuropeptide-mediated cardiovascular regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":4},{"id":"GO:0032651","count":4},{"id":"GO:0007218","count":4},{"id":"GO:2000724","count":4},{"id":"GO:0090075","count":4}]},{"hash":"1986594324842648479","title":"Neuropeptide signaling and cardiovascular regulation","description":"The dominant terms point to neuropeptide signaling and hormonal control of cardiovascular functions, including vasopressin-regulated blood pressure and renin secretion, with a peripheral signal of dopamine uptake regulation. This indicates a cohesive neuroendocrine/neurotransmitter theme governing cardiovascular regulation, with some immune-related terms as ancillary. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043950","count":1},{"id":"GO:0032651","count":1},{"id":"GO:0007218","count":1},{"id":"GO:2000724","count":1},{"id":"GO:0090075","count":1}]},{"hash":"1129690143178411426","title":"Neuropeptide signaling and vascular regulation","description":"This cluster is dominated by terms related to neuropeptide signaling and controlling vascular function, including neuropeptide signaling pathway, vasopressin-mediated regulation of arterial blood pressure, and renin secretion. Additional terms point to dopamine signaling, muscle relaxation, and immune mediator regulation, suggesting a neuroendocrine\u2013vascular axis with some immune cross-talk. The label captures the central theme of neuropeptide-driven regulation of vascular tone and related signaling.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043950","count":3},{"id":"GO:0032651","count":3},{"id":"GO:0007218","count":3},{"id":"GO:2000724","count":3},{"id":"GO:0090075","count":3}]},{"hash":"1895415950465390708","title":"Cytoskeleton remodeling during development","description":"The terms center on cytoskeletal dynamics (actin and microtubule regulation, cell\u2013cell adhesion) intertwined with developmental processes across tissues (ectoderm, hair follicle, kidney, brain), suggesting a cluster of proteins involved in cytoskeleton remodeling during development and EMT.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0090138","count":5},{"id":"GO:0044334","count":5},{"id":"GO:0007026","count":5},{"id":"GO:0007398","count":5},{"id":"GO:0072699","count":5}]},{"hash":"119250745066968599","title":"Cerebellar Cortex Development and Neuronal Signaling","description":"The dominant terms center on cerebellar cortex formation and development (cerebellar cortex formation, cerebellar cortex development) and Bergmann glial cell differentiation, with related neuronal signaling (excitatory postsynaptic potential). While immune and insulin-related terms appear, they are less representative of the core module, which appears to be cerebellar neuron/glia development and signaling.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0050852","count":4},{"id":"GO:0021697","count":4},{"id":"GO:0048679","count":4},{"id":"GO:0060020","count":4},{"id":"GO:2001275","count":4}]},{"hash":"1676892446300726211","title":"Neural adhesion and synapse organization","description":"This cluster is dominated by GO terms related to neural cell\u2013cell adhesion (homophilic and heterophilic), synapse assembly, and axon-domain organization (paranodal and juxtaparanodal regions), plus neuron migration cues. Together they point to a cohesive module governing neuronal adhesion, synapse formation, and axon\u2013glia junction organization, despite a couple of broader developmental terms appearing as minor signals.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0021836","count":2},{"id":"GO:0030913","count":2}]},{"hash":"1380136612757698426","title":"Brain development and synaptic regulation","description":"Based on the dominant GO terms, the proteins appear involved in brain development and synaptic function: cerebellar cortex development, excitatory postsynaptic potentials, responses related to environmental enrichment, and regulation of synaptic plasticity. While a few terms touch on non-neural processes, the strongest signals consistently point to neural development and synaptic signaling as the cluster\u2019s core theme.","confidence":"High","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0090648","count":5},{"id":"GO:0021695","count":5},{"id":"GO:0097350","count":5},{"id":"GO:0060079","count":5},{"id":"GO:0090188","count":5}]},{"hash":"609095851313381216","title":"Innate Immune Signaling and Inflammation","description":"The top GO terms are dominated by innate immune sensing and inflammatory pathways (TLR4 signaling, PRR signaling, inflammatory response, response to virus), indicating the cluster centers on immune recognition and consequent inflammatory responses. Some terms about glycosylation or other processes appear less clearly related, likely noise, but the immune theme is clear and representative.","confidence":"High","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046329","count":1},{"id":"GO:0035269","count":1},{"id":"GO:0060049","count":1},{"id":"GO:0006689","count":1},{"id":"GO:0061057","count":1}]},{"hash":"886845073959330739","title":"Unknown","description":"The GO terms span mitochondrial and peroxisomal dynamics, autophagy, trafficking, ribosome biogenesis, and stress responses with no clear unifying function. With no edges connecting the proteins, there isn\u2019t a cohesive theme to designate a specific cluster role, so the appropriate label is Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070584","count":1},{"id":"GO:0016559","count":1},{"id":"GO:0034340","count":1},{"id":"GO:0010636","count":1},{"id":"GO:0090529","count":1}]},{"hash":"1345892451620118448","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0032197","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0039651","count":2}]},{"hash":"2019065470025712957","title":"Chromatin Maintenance and Meiosis Regulation","description":"This cluster centers on chromatin dynamics and transcription control, with links to meiotic progression and sporulation. The top terms include nucleosome positioning and heterochromatin maintenance (chromatin architecture), negative regulation of antisense RNA transcription (transcriptional control), telomere-related processing, and key meiotic/sporulation terms such as ascospore formation and regulation of meiotic joint molecule formation, suggesting a cohesive theme around chromatin regulation during meiosis. Some terms are labeled obsolete in the dataset, indicating incomplete or transitional annotations, but the core signal supports a chromatin-meiosis functional cluster.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060195","count":1},{"id":"GO:0061820","count":1},{"id":"GO:1902775","count":1},{"id":"GO:0071038","count":1},{"id":"GO:1990414","count":1}]},{"hash":"1771441814853481902","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0071031","count":2},{"id":"GO:0075525","count":2}]},{"hash":"216480084540673145","title":"Nuclear RNA Processing and Spliceosome Activity","description":"The terms cluster around nuclear RNA metabolism, including transcription termination by RNA Pol II, mRNA processing and splicing with spliceosome assembly, and nuclear import, plus supporting factors like histone mRNA metabolism and tRNA processing. Stress-related terms (response to ABA and water deprivation) may reflect regulatory context rather than core function, but the central theme remains nuclear RNA processing/splicing.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006369","count":4},{"id":"GO:0000290","count":2},{"id":"GO:0008033","count":2},{"id":"GO:0008334","count":2},{"id":"GO:0009414","count":2}]},{"hash":"1781388984742158147","title":"DNA Damage Response and p53-Mediated Cell Cycle Control","description":"These terms point to a DNA damage response network with p53 signaling and cell cycle control, along with proteostasis and translation-related processes. The presence of regulation of the cell cycle and positive regulation of p53 mediator signaling, plus a cellular response to actinomycin D and ubiquitin-related regulation, suggests proteins in this cluster coordinate DNA damage sensing, cell cycle arrest, and maintenance of protein homeostasis under stress. ","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0071157","count":2},{"id":"GO:0050821","count":2},{"id":"GO:0032986","count":2},{"id":"GO:2000059","count":2}]},{"hash":"396476779882067964","title":"Embryonic Organogenesis","description":"The proteins map to diverse developmental and morphogenetic processes across several tissues\u2014endodermal fate, atrial septum morphogenesis, uterus and ureteric bud development, spinal cord interneuron differentiation, and nerve branching\u2014suggesting a cohesive theme of organogenesis and tissue formation. The cytokine-related terms (IL-4, IL-13, IL-2 regulation) may reflect regulatory or crosstalk roles during development but do not override the primary morphogenesis signal. Thus, a label centered on embryonic organogenesis best captures the cluster. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071353","count":3},{"id":"GO:0007493","count":3},{"id":"GO:0045654","count":3},{"id":"GO:0003290","count":3},{"id":"GO:0060065","count":2}]},{"hash":"1093315440948815719","title":"Ubiquitin-Dependent Endocytosis and ERK Signaling","description":"The top GO terms point to ubiquitination and endocytosis (including ubiquitin-dependent endocytosis and endocytic recycling) along with regulation of ERK signaling, stress fiber assembly, and transcription. This pattern suggests proteins that coordinate ubiquitin-driven trafficking with signaling pathways and cytoskeletal dynamics, rather than a single isolated function. Given the mixed but related terms and small cluster size, the connection is plausible but not tightly constrained.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050975","count":2},{"id":"GO:0043149","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0033138","count":2}]},{"hash":"1294192390042215296","title":"Copper transport and homeostasis","description":"The cluster centers on copper ion import and intracellular copper homeostasis, with terms for regulation of copper transmembrane transport and related cisplatin response, pointing to a shared function in metal handling. While other terms touch on broader metal-related processes (e.g., Fe-S assembly, tRNA modification), the copper-related terms strongly dominate the theme.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031047","count":2},{"id":"GO:0045226","count":1},{"id":"GO:0002098","count":1},{"id":"GO:0016226","count":1},{"id":"GO:0006878","count":1}]},{"hash":"998547772188367132","title":"RNA processing and translational regulation","description":"The majority of GO terms point to post-transcriptional control: splicing via spliceosome, mRNA export, regulation of mRNA stability under stress, miRNA- and regulatory ncRNA-mediated silencing, and eIF4F complex assembly, indicating RNA maturation and translation initiation/repression. Some terms like apical localization and mitochondrial inheritance are more peripheral but may reflect broader cellular organization. Overall, the cluster centers on RNA metabolism and translational control.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045176","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0070528","count":2},{"id":"GO:0048026","count":1},{"id":"GO:0075525","count":1}]},{"hash":"597897898820969027","title":"Membrane-Localized Signaling and Adhesion Regulation","description":"Reasoning: The top GO terms converge on membrane-related localization (membrane rafts, lipid localization) and cell\u2013cell interactions (cadherin-mediated adhesion, extracellular matrix disassembly). Mitochondrial dynamics and dopaminergic synaptic signaling may be indirect connections, but the strongest common theme is membrane-associated localization and adhesion signaling.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070584","count":2},{"id":"GO:1903044","count":2},{"id":"GO:0010876","count":2},{"id":"GO:0032226","count":2},{"id":"GO:2000049","count":2}]},{"hash":"1572421630654113338","title":"RNA splicing and post-transcriptional control","description":"The terms cluster around RNA processing: splicing (including spliceosome regulation and alternative splicing), mRNA export, and mRNA stability, as well as post-transcriptional regulation through miRNA and other ncRNA-mediated silencing and translation-related processes. This suggests a cohesive theme of coordinating RNA maturation and control of gene expression at the post-transcriptional level, including translation initiation and viral translation reinitiation contexts.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048026","count":2},{"id":"GO:0075525","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0006406","count":2}]},{"hash":"1275246869933861810","title":"Transmembrane Transport of Small Molecules","description":"The Top Terms show multiple transmembrane transport processes across diverse substrates (nitrate, sodium ions, arabinose, galactose, trehalose, selenite, L-ascorbic acid, xenobiotics) and a vesicle-related term (neurotransmitter loading into synaptic vesicle). This suggests a cluster of proteins functioning in membrane transport of small molecules rather than a single, specific substrate, so a general label of transmembrane transport of small molecules fits best.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0015751","count":2},{"id":"GO:0097080","count":2},{"id":"GO:0019852","count":2}]},{"hash":"1022807867935084454","title":"Unknown","description":"The GO terms show a mix of fungal-specific biosynthesis (beta-glucan), core cellular processes (DNA replication, iron-sulfur cluster assembly, protein targeting to membranes) and unrelated or obsolete terms, with no single unifying function tying the proteins together beyond general cellular activity. This suggests annotation noise rather than a coherent cluster function.","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070880","count":2},{"id":"GO:1902037","count":2},{"id":"GO:0016226","count":2},{"id":"GO:0006880","count":2},{"id":"GO:0000742","count":2}]},{"hash":"1385185269399745815","title":"RNA processing and translation","description":"This cluster centers on translation and various RNA-related processes: translation, maturation of SSU rRNA, RNA splicing (positive regulation), RNA folding, tRNA ribose methylation, and mRNA capping. The common theme is RNA metabolism supporting protein synthesis. A few terms (antibiotic response, symbiont-related autophagy) are peripheral and don\u2019t define the core function.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0006450","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0000372","count":1}]},{"hash":"1472614584775333884","title":"Developmental transcriptional regulation","description":"The GO terms indicate broad involvement in embryonic development and organogenesis, including heart tube formation, bronchiole development, oculomotor nerve development, mesenchyme formation, and differentiation pathways (osteoblast, myotube). The recurring DNA-templated transcription term suggests these proteins act as transcriptional regulators that modulate gene expression during development, rather than a single tissue-specific function. Confidence that the label captures the cluster\u2019s theme is medium due to the diverse, multi-tissue scope.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060766","count":4},{"id":"GO:0045668","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0010832","count":3},{"id":"GO:0060435","count":3}]},{"hash":"2094608016587418480","title":"Chromatin Organization and Assembly","description":"The top GO terms emphasize chromatin-related processes such as establishment of protein localization to chromatin, CENP-A\u2013containing chromatin assembly, nucleus organization, and heterochromatin formation, indicating a cohesive theme of chromatin maintenance. A few terms related to muscle and germ-cell differentiation appear, but these likely reflect downstream developmental programs influenced by chromatin state.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":3},{"id":"GO:0042692","count":2},{"id":"GO:0003209","count":2},{"id":"GO:2000973","count":2},{"id":"GO:0007286","count":2}]},{"hash":"1175749478006634747","title":"Olfactory and cortical neuron development","description":"The top GO terms point to neuronal development and migration in olfactory and cortical regions (olfactory bulb mitral cell layer development; tangential migration to the olfactory bulb; pyramidal neuron development; cerebellar cortex development). Although a few metabolic biosynthetic terms appear, the dominant signal is neurite formation and migration within brain regions, suggesting these proteins participate in olfactory and cortical neuronal development and organization.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0061034","count":2},{"id":"GO:0009083","count":2},{"id":"GO:0021695","count":2},{"id":"GO:0046166","count":2},{"id":"GO:0009228","count":2}]},{"hash":"221846771257798208","title":"Nucleic acid processing and proviral integration","description":"The GO terms highlight both RNA-level processes (translation, ribosomal RNA maturation) and DNA-level/nucleic-acid processes (DNA replication, recombination, DNA integration, proviral latency, viral genome handling). This points to a cohesive theme around nucleic acid metabolism and virus\u2013host genome interactions, with translation-related steps threading into both aspects. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006417","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0000470","count":1},{"id":"GO:0006278","count":1},{"id":"GO:1903704","count":1}]},{"hash":"794336145146653324","title":"Glyoxylate/TCA Cycle Metabolism","description":"The top GO terms are dominated by central carbon metabolism (isocitrate, 2-oxoglutarate, glyoxylate cycle) and NADP+ biosynthesis, indicating a metabolism-focused cluster, with a couple outliers related to development and glial migration.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006102","count":2},{"id":"GO:0008585","count":2},{"id":"GO:0006097","count":2},{"id":"GO:1903976","count":2},{"id":"GO:0048545","count":2}]},{"hash":"2038874905214488096","title":"Unknown","description":"These proteins show no clear single-function theme; the GO terms span peroxisome fission, cell cycle regulation, post-translational modification (deneddylation and K11-linked deubiquitination), ergosterol biosynthesis regulation, exosomal secretion, spliceosomal changes, and stress responses such as ethanol exposure, indicating a heterogeneous cluster without a coherent shared function.","confidence":"","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016559","count":1},{"id":"GO:0051726","count":1},{"id":"GO:0000338","count":1},{"id":"GO:0070452","count":1},{"id":"GO:0035871","count":1}]},{"hash":"1272926199553921289","title":"Proviral Integration and Latency","description":"These proteins show a cohesive theme around retroviral lifecycle steps: reverse transcription (RNA-templated DNA synthesis), DNA integration into the host genome, and establishment of proviral latency, plus viral entry into the host nucleus. While a few terms hint at general symbiont interactions, the dominant signals point to proviral integration and latency as the core function of this cluster.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006278","count":1},{"id":"GO:0090502","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0043137","count":1},{"id":"GO:0007084","count":1}]},{"hash":"1106865155292573824","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000378","count":2},{"id":"GO:0008306","count":2},{"id":"GO:1903608","count":2},{"id":"GO:1902775","count":2},{"id":"GO:0071042","count":2}]},{"hash":"1315915292990197173","title":"Methylation and Cofactor Biosynthesis","description":"This cluster shows strong signals for methylation-related processes (protein methylation, tRNA methylation, general methylation) together with several biosynthetic pathways for cofactors and related metabolites (menaquinone, cobalamin, antibiotic biosynthesis) and RNA processing. The combination suggests a theme around RNA/nucleic acid modification and associated biosynthetic pathways for cofactors in bacterial metabolism, though the mix is broad.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":2},{"id":"GO:0032259","count":2},{"id":"GO:0030488","count":2},{"id":"GO:0009236","count":2},{"id":"GO:0017000","count":2}]},{"hash":"510626971062934799","title":"Adipogenesis and fatty acid biosynthesis","description":"The GO terms point to fat cell development (white fat cell differentiation) and lipid metabolism (monounsaturated fatty acid biosynthesis, sphingosine biosynthesis, response to fatty acid), suggesting a cohesive theme of adipocyte formation and lipid biosynthesis. Some broader development and signaling terms (multicellular development, STAT signaling) likely reflect regulatory pathways modulating this metabolic/adipogenic program, aligning with a cluster centered on adipogenesis and fatty acid metabolism.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0042511","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0070542","count":1},{"id":"GO:0046512","count":1}]},{"hash":"7825439799281087","title":"Unknown","description":"The proteins in this cluster show a highly diverse set of GO terms spanning immune defense, neural development and signaling, muscle regeneration, and extracellular matrix remodeling, with no clear shared function or pathway connecting them. The lack of edges or cohesive enrichment prevents a single, representative label.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0090648","count":1},{"id":"GO:0021695","count":1},{"id":"GO:0097350","count":1},{"id":"GO:0060079","count":1}]},{"hash":"1734930710430977515","title":"Nucleotide metabolism and DNA replication initiation","description":"The cluster\u2019s terms heavily emphasize nucleotide metabolism (nucleoside monophosphate phosphorylation; purine ribonucleotide interconversion; ITP/GTP/CDP metabolic processes; NAD+ biosynthesis) and there is also a direct link to DNA replication initiation, suggesting a theme of coordinating nucleotide biosynthesis with DNA synthesis. The liver development term appears as an outlier and does not alter the core pattern.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001889","count":2},{"id":"GO:0019619","count":1},{"id":"GO:0060702","count":1},{"id":"GO:0046940","count":1},{"id":"GO:0015951","count":1}]},{"hash":"997760552650535096","title":"Ribosome biogenesis and translation","description":"The cluster is dominated by GO terms for ribosome biogenesis, rRNA processing, large subunit assembly, and nuclear export, along with translation elongation and fidelity, pointing to a cohesive theme of ribosome maturation and protein synthesis. Only a small handful of terms relate to cellular stress or DNA repair, which does not shift the main functional signal.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071479","count":1},{"id":"GO:1990145","count":1},{"id":"GO:0006414","count":1},{"id":"GO:0032232","count":1},{"id":"GO:0000463","count":1}]},{"hash":"1254826359852009408","title":"Spermatogenesis and male gonad development","description":"This cluster is enriched for GO terms tied to male germ cell development, spermatogenesis, and regulation of germ cell proliferation, indicating a primary association with male reproductive development. Additional terms about oxidative stress response and signaling (MAPK, NF-kB/I-kappaB phosphorylation) may reflect supportive regulatory pathways active in germ cells, but the dominant theme is male germ cell maturation and gonadal development.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2000255","count":2},{"id":"GO:0034101","count":2},{"id":"GO:0017004","count":2},{"id":"GO:0022417","count":2},{"id":"GO:0007252","count":2}]},{"hash":"776968933780969066","title":"Unknown","description":"The top GO terms cover very diverse biological themes (DNA replication and transcription; innate immune response and neutrophil clearance; apoptosis; brain and muscle development; neuronal signaling; and environmental or secretory regulation), with no single unifying function. This lack of a cohesive common theme suggests the cluster does not reflect one clear biological process, so I label it Unknown with no confidence in a representative function.","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0090648","count":3}]},{"hash":"1247416729953786850","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006006","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006096","count":2},{"id":"GO:0051402","count":1},{"id":"GO:0009089","count":1}]},{"hash":"2212502981864110021","title":"Immune signaling and transcription","description":"Based on the top GO terms, the proteins are enriched for responses to immune stimuli (GM-CSF stimulus, T cell receptor signaling, and lipopolysaccharide response). A fourth common term, DNA-templated transcription, suggests transcriptional regulation in response to such stimuli. Other terms related to neural development or muscle regeneration appear less connected and may reflect broader annotations of multifunctional proteins. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097011","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0090648","count":3}]},{"hash":"1904677502043635049","title":"Unknown","description":"The GO terms are highly diverse, including signaling regulation (negative regulation of protein kinase activity), calcium transport, cytoskeletal assembly (myosin II), and neural plasticity (long-term potentiation), but also development and organism-specific processes (heart rate regulation, metanephric kidney development, insect cuticle, fungal karyogamy). With no connecting function and no edges among the proteins, there is no coherent theme uniting this cluster, so Unknown is the appropriate label.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":2},{"id":"GO:0043950","count":1},{"id":"GO:0010459","count":1},{"id":"GO:0072205","count":1},{"id":"GO:0060291","count":1}]},{"hash":"330646607693773555","title":"Broad Developmental Processes","description":"The top GO terms are dominated by development-related topics across multiple tissues (skeletal system, forebrain, multicellular organism, immune system, and gland development), suggesting a broad, multi-tissue developmental role for the cluster. There are additional terms linked to cellular organization and stress-related responses that can intersect with development, but the common thread is developmental biology rather than a single specific pathway. Therefore, a broad label like Broad Developmental Processes captures the cluster\u2019s gist without overfitting to one function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0030900","count":2},{"id":"GO:0007275","count":2}]},{"hash":"812870627746023748","title":"Vesicle trafficking to lysosomes and vacuoles","description":"The GO terms cluster around vesicle-mediated transport, protein targeting to lysosomes and vacuoles, clathrin-coated vesicle cargo loading, and the multivesicular body sorting pathway, suggesting a vesicle trafficking/lysosomal targeting role, despite some unrelated terms present as noise.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045053","count":1},{"id":"GO:0031321","count":1},{"id":"GO:1901998","count":1},{"id":"GO:2000274","count":1},{"id":"GO:0045752","count":1}]},{"hash":"657624145439267894","title":"Neural crest migration and axon guidance","description":"The top GO terms cluster around neural development, including ventral trunk neural crest cell migration, commissural neuron axon guidance, sympathetic ganglion development, and several neuronal migration processes (e.g., gonadotropin-releasing hormone neurons). Additional terms on retina vasculature morphogenesis and ear development further support a broad neural development theme. A few lipid metabolism terms are present but do not dominate, so the central signal appears to be neural development and axon guidance.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902378","count":1},{"id":"GO:0036486","count":1},{"id":"GO:0061549","count":1},{"id":"GO:0061299","count":1},{"id":"GO:0043583","count":1}]},{"hash":"1255709297447673278","title":"Neural development and synaptic organization","description":"This cluster is enriched for nervous system development and synaptic processes, including sympathetic ganglion development, commissural axon guidance, vestibulocochlear nerve organization, and regulation of synaptic vesicle endocytosis, with supporting cell adhesion terms that fit neural connectivity. Some non-neural terms appear, but they do not overturn the core neural theme.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061549","count":2},{"id":"GO:0071679","count":2},{"id":"GO:0010758","count":2},{"id":"GO:0061302","count":2},{"id":"GO:1902168","count":2}]},{"hash":"1522519125706793872","title":"Unknown","description":"The top GO terms span diverse processes\u2014from development and pain perception to VEGF signaling, cardiac repolarization, circadian regulation, and ion/homeostatic functions\u2014without a single cohesive function tying the proteins together. There isn\u2019t a clear, representative theme to name this cluster, so it is labeled Unknown with no confidence.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0048010","count":2},{"id":"GO:0019228","count":2},{"id":"GO:0060453","count":2}]},{"hash":"1271654092711442838","title":"Retroviral entry and proviral integration","description":"Based on GO terms such as RNA-templated DNA biosynthetic process (reverse transcription), DNA integration, DNA recombination, DNA replication, establishment of integrated proviral latency, and viral penetration into the host nucleus, this cluster maps well to the retroviral life cycle and genome integration events. While a couple terms mention general symbiont-host interactions, the dominant theme is viral entry, reverse transcription, and proviral integration into host DNA, indicating a retroviral infection module. Therefore, a label focused on retroviral entry and proviral integration best captures the cluster\u2019s function.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006278","count":3},{"id":"GO:1903704","count":3},{"id":"GO:0075713","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0006310","count":3}]},{"hash":"1606200040946575322","title":"DNA Damage Repair and Ubiquitination","description":"The GO terms suggest a focus on DNA damage response pathways (interstrand cross-link repair, error-prone translesion synthesis, and certain double-strand break repair mechanisms) and ubiquitin-related processes (polyubiquitination and free ubiquitin chain polymerization), indicating a theme of repair signaling modulated by ubiquitination. Some terms like ribosome biogenesis and tRNA modification are less clearly connected and may reflect broader cellular functions or annotation noise, but the dominant signal points to DNA repair with ubiquitin involvement.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036297","count":1},{"id":"GO:0000209","count":1},{"id":"GO:0042276","count":1},{"id":"GO:0045003","count":1},{"id":"GO:0010994","count":1}]},{"hash":"1968584517282696365","title":"Unknown","description":"The GO terms are highly diverse and span behavioral responses, immune activation, cell adhesion and ECM dynamics, stress responses, and even plant-specific metabolism (chlorophyll catabolic process). There is no single coherent biological function or pathway that ties these proteins together, suggesting the cluster is not functionally coherent. Therefore, assign Unknown with no confidence (None). ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001662","count":1},{"id":"GO:0050796","count":1},{"id":"GO:0098869","count":1},{"id":"GO:0033632","count":1},{"id":"GO:0042110","count":1}]},{"hash":"1181121032270053811","title":"Symbiont dormancy and stress response","description":"The prominent GO terms point to dormancy entry of a symbiont in a host and general stress response, reinforced by links to autophagy and proteasomal turnover, plus metabolic adjustments (carbon dioxide response and utilization). While a few terms are more peripheral, the common theme is host-associated cellular stress adaptation and protein homeostasis during dormancy.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0085014","count":2},{"id":"GO:0006950","count":2},{"id":"GO:2000122","count":1},{"id":"GO:0071244","count":1},{"id":"GO:0015976","count":1}]},{"hash":"2035228279441127514","title":"Retroviral DNA Integration and Latency","description":"Based on the GO terms, the proteins cluster around retroviral life-cycle steps: reverse transcription (RNA-templated DNA biosynthesis), DNA recombination and integration, viral entry into the host nucleus, DNA replication, and establishment of integrated proviral latency, with ancillary notes on host RNAi regulation and apoptosis during symbiont/virus interaction. This coherence supports a retroviral integration/latent-phase role for the cluster.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0006278","count":2},{"id":"GO:1903704","count":2},{"id":"GO:0075713","count":2}]},{"hash":"2040586915561698387","title":"RNA Methylation and Processing","description":"The Top Terms clearly center on methylation activities, including rRNA (guanine-N7)-methylation, 7-methylguanosine mRNA capping, and peptidyl-arginine methylation, with an obsolete histone methylation term; together these suggest a theme of methylation-based regulation of RNA and proteins. Other terms (lipid biosynthesis, xenobiotic response) are less cohesive with this core signal, so the label emphasizes the strongest common function in the cluster.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":2},{"id":"GO:0001300","count":1},{"id":"GO:0006370","count":1},{"id":"GO:0016126","count":1},{"id":"GO:0006656","count":1}]},{"hash":"969252201915788608","title":"Unknown","description":"The terms span DNA replication, neural development, cerebellar cortex development, neutrophil clearance, excitatory synaptic potential, pancreatic secretion regulation, myoblast differentiation, extracellular matrix disassembly regulation, PDGF response, and diadenosine tetraphosphate biosynthesis. With no shared pathway or cohesive function and no edges connecting the proteins, there is no clear theme to label the cluster beyond Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0090648","count":1},{"id":"GO:0021695","count":1},{"id":"GO:0097350","count":1},{"id":"GO:0060079","count":1}]},{"hash":"95898930950038894","title":"Tryptophan-Kynurenine Metabolism","description":"Based on the top GO terms, several entries point to tryptophan catabolism to kynurenine and kynurenic acid biosynthesis, i.e., the kynurenine pathway. Although additional terms (heme biosynthesis, insulin response, and some obsolete terms) appear, the recurring theme is tryptophan degradation through kynurenine, indicating the cluster represents kynurenine pathway metabolism.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019878","count":3},{"id":"GO:0019441","count":2},{"id":"GO:0019518","count":2},{"id":"GO:0097053","count":2},{"id":"GO:0019550","count":2}]},{"hash":"1246045636941530506","title":"Diverse small-molecule metabolism","description":"Based on the GO terms, the four proteins map to a range of catabolic and biosynthetic processes involving steroids, propylene, retinal, melanin, methyl-branched fatty acids, PHB, acetoin, and phylloquinone, as well as sporulation. This pattern indicates broad involvement in metabolism of diverse, small molecules rather than a single specific pathway, so the label reflects a general metabolic capability rather than a precise function.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006706","count":4},{"id":"GO:0030324","count":4},{"id":"GO:0042208","count":4},{"id":"GO:0042574","count":4},{"id":"GO:0042619","count":4}]},{"hash":"1695340299525978940","title":"Steroid Hormone Biosynthesis and Metabolism","description":"Top GO terms show strong enrichment for estrogen and testosterone biosynthesis and androgen catabolic processes, plus related steroid and lipid metabolic activities. This points to a shared role in steroid hormone production and turnover, with other terms like lung development or antibiotic response likely reflecting broader or incidental annotations. Confidence: Medium","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006703","count":2},{"id":"GO:0006666","count":2},{"id":"GO:0046677","count":2}]},{"hash":"527481319409370239","title":"Immune signaling and cell clearance","description":"The GO terms most strongly point to immune-related signaling and clearance processes (apoptotic cell clearance, neutrophil clearance, T cell receptor signaling, and cell adhesion). While there are a few neuronal development and synaptic terms present (retinal ganglion axon guidance, synaptic plasticity, neuron death), the prominent theme centers on signaling pathways and clearance in immune contexts. This suggests a cluster of proteins involved in immune signaling with some cross-talk to neural signaling. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1902955","count":2},{"id":"GO:0043277","count":2},{"id":"GO:0038161","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0097350","count":2}]},{"hash":"931789593121774539","title":"Developmental and Immune Signaling","description":"The top terms point to Hedgehog/Smoothened signaling involved in organ development (heart, kidney, nervous system) and also include immune-related pathways (prolactin signaling, T cell receptor signaling) along with cell clearance processes. This pattern suggests proteins participate in broader signaling networks that influence development and immune functions, rather than a single isolated pathway, hence a label that reflects both developmental and immune signaling themes.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007224","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0007399","count":3},{"id":"GO:1902955","count":2}]},{"hash":"368294143714790636","title":"Paranode localization and myelination","description":"This cluster centers on neural development and axon biology, with GO terms pointing to paranode protein localization, myelination, synapse organization, nerve impulse transmission, and clustering of voltage-gated sodium channels, plus Hedgehog pathway signaling (Smoothened). While a couple terms like angiogenesis or neutrophil clearance are less directly related, the dominant theme is axon maturation and synaptic/ion-channel organization, implying a shared role in myelinated nerve fiber development and function.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0097350","count":3},{"id":"GO:0007224","count":3},{"id":"GO:0002175","count":3},{"id":"GO:0042552","count":3},{"id":"GO:0001525","count":3}]},{"hash":"1308771918833618803","title":"Neural development and synaptic signaling","description":"The top GO terms cluster around brain development, synaptic vesicle exocytosis, excitatory signaling, and actin remodeling at synapses, suggesting proteins involved in neural development and synaptic transmission. While a single term about hair follicle morphogenesis appears, the dominant terms point to neuronal processes and synaptic function, supporting a label centered on neural development and synaptic signaling.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0010796","count":3},{"id":"GO:0031384","count":3},{"id":"GO:2000300","count":3},{"id":"GO:0031069","count":2}]},{"hash":"1148239176439907507","title":"Unknown","description":"The top GO terms cover apoptosis, extrinsic apoptotic signaling, and various unrelated processes (platelet activation, NFAT signaling, synaptic vesicle endocytosis, retina development, gland morphogenesis), with no clear, single shared function among the four proteins. The mix suggests no coherent cluster theme.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006919","count":2},{"id":"GO:0030168","count":2},{"id":"GO:0051533","count":2},{"id":"GO:1900242","count":2},{"id":"GO:0010842","count":2}]},{"hash":"1388933375179362462","title":"Unknown","description":"The GO terms across the four proteins are highly diverse, spanning deglutathionylation, transcription, translation, protein folding, nuclear export, and signaling with no single cohesive function linking them. With no edges and only one occurrence per term, there is no clear common theme to define a specific cluster name.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0080058","count":1},{"id":"GO:1903206","count":1},{"id":"GO:0071374","count":1},{"id":"GO:0046826","count":1},{"id":"GO:0032781","count":1}]},{"hash":"443372774500733709","title":"Unknown","description":"The top GO terms are scattered across mitosis, Golgi retention, lens development, and Rho signaling, with no single cohesive function tying them together. With only 4 proteins and no observed interactions, there isn\u2019t a clear module to label, so this cluster is Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060316","count":2},{"id":"GO:0035023","count":2},{"id":"GO:1902188","count":1},{"id":"GO:0045053","count":1},{"id":"GO:0090148","count":1}]},{"hash":"200016160356287363","title":"Neuronal development and proteostasis","description":"The top GO terms center on neural development (synapse assembly, neural tube closure, third ventricle development, multicellular organism development) and ubiquitin-dependent proteolysis (ERAD, protein catabolic process), suggesting a theme of neuronal formation plus protein turnover. Some terms also reflect cellular stress responses (cadmium ion, oxidative stress), but the dominant signal is neural development with a proteostasis component.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060386","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0071276","count":2},{"id":"GO:0021678","count":2}]},{"hash":"635184774069098579","title":"Proviral integration and latency","description":"These terms cluster around retroviral-like processes: RNA-templated DNA biosynthesis, DNA integration and recombination, DNA replication, and, notably, establishment of integrated proviral latency and viral entry into the host nucleus. The presence of host-symbiont interaction terms complements this theme, but the cohesive thread is proviral integration and latency mechanisms. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006278","count":2},{"id":"GO:1903704","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0006310","count":2}]},{"hash":"2210037473792277027","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":3},{"id":"GO:0048536","count":3},{"id":"GO:0000185","count":2},{"id":"GO:0007014","count":2},{"id":"GO:0007026","count":2}]},{"hash":"1667785831378669020","title":"Glutamatergic synaptic signaling","description":"The top GO terms center on ionotropic glutamate receptor signaling, excitatory postsynaptic potential, and calcium ion transport, all core features of glutamatergic neurotransmission at synapses. Other terms like startle response and dopamine metabolism reflect neuronal signaling contexts, while ER protein folding and redox homeostasis are more general housekeeping processes. Taken together, the cluster appears to reflect glutamatergic synaptic signaling and associated calcium dynamics.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034975","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0035725","count":1},{"id":"GO:0035235","count":1},{"id":"GO:0001964","count":1}]},{"hash":"74131831239060424","title":"Oxidative Stress Response and NF-kappaB Signaling","description":"The top GO terms point to cellular responses to oxidative stress (hydrogen peroxide) and hormonal stress (estradiol), coupled with regulatory signaling around survival pathways (negative regulation of necroptosis) and inflammatory signaling (positive regulation of canonical NF-kappaB). While there are a few tissue/development terms present, the recurring themes center on stress response and NF-kappaB\u2013related signaling, suggesting a cluster focused on stress- and inflammation-related regulation rather than a single developmental program.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042542","count":2},{"id":"GO:0032355","count":2},{"id":"GO:0060546","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0072205","count":1}]},{"hash":"1010652083881337544","title":"Neuroendocrine Regulation of Vascular Function","description":"Most of the top GO terms relate to neural signaling and hormonal control of cardiovascular function, including neuropeptide signaling, dopamine uptake regulation, and vasopressin-mediated blood pressure regulation. A few terms (blood coagulation, IL-1 beta production) are less directly connected but may reflect background signaling cross-talk. Overall, the cluster appears to reflect neuroendocrine regulation of vascular and muscle function, possibly affecting blood pressure and locomotor behavior.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0043950","count":1},{"id":"GO:0032651","count":1},{"id":"GO:0007218","count":1},{"id":"GO:2000724","count":1}]},{"hash":"722993508758282137","title":"Unknown","description":"The GO terms span proteostasis (proteasome assembly and ubiquitin-dependent catabolism), plant-specific development (chlorophyll biosynthesis and stamen formation), and RNA processing (snRNA processing), with no single cohesive function linking all four proteins. ","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043248","count":1},{"id":"GO:0015995","count":1},{"id":"GO:0048455","count":1},{"id":"GO:0006511","count":1},{"id":"GO:0016180","count":1}]},{"hash":"1862794524784802772","title":"Ubiquitin-Dependent Antiviral Immune Signaling","description":"GO terms center on ubiquitination processes (autoubiquitination, protein ubiquitination, polyubiquitination, ubiquitin-dependent catabolic process) and immune responses (innate/adaptive, defense against virus) with a specific note on negative regulation of RIG-I signaling. A few axon guidance terms appear but are likely peripheral. The dominant theme is ubiquitin-mediated regulation of antiviral immune pathways.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0039536","count":2},{"id":"GO:0007413","count":2}]},{"hash":"932277393988749473","title":"Unknown","description":"The GO terms span reproductive development, immune responses, calcium signaling, hormone secretion, ERK signaling, apoptosis, and thymic development, with no single dominant theme tying them together. This mix suggests multiple distinct processes rather than a cohesive cluster function.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048609","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0046887","count":2},{"id":"GO:0051281","count":2},{"id":"GO:0070374","count":2}]},{"hash":"759389202192144456","title":"Mitochondrial quality control under stress","description":"The set is dominated by terms tied to mitochondria: mitophagy and positive regulation of mitochondrial fusion, suggesting a theme of mitochondrial quality control. Additional GO terms indicate cellular stress responses (cadmium, insecticide exposure, heat acclimation) and calcium signaling in muscle, which can intersect mitochondrial function in cardiac and muscle cells. A ribosomal RNA maturation term appears as a potential outlier, but overall the cluster maps best to mitochondrial maintenance under stress.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1901340","count":2},{"id":"GO:0086004","count":2},{"id":"GO:0002109","count":2},{"id":"GO:0010636","count":2},{"id":"GO:0045944","count":2}]},{"hash":"366979749261517252","title":"Embryonic development and lineage differentiation","description":"The Top Terms show strong signals for developmental processes and lineage specification: blastocyst development, granulocyte, goblet cell, myeloid dendritic cell differentiation, epithelial cell proliferation, and angiogenesis. There are also epigenetic/dna replication elements (CpG island methylation regulation, DNA replication) and a stress response term (SOS response), which can be relevant during development and cellular remodeling. Overall, the cluster appears to group proteins involved in early development and subsequent differentiation and tissue remodeling, with a few outliers from broader cellular stress and replication processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001824","count":3},{"id":"GO:0009432","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0030851","count":2},{"id":"GO:0060480","count":2}]},{"hash":"454715218219103525","title":"Neural development and synaptic plasticity regulation","description":"The cluster\u2019s top GO terms cluster around neural development and synaptic function (cerebellar cortex development, excitatory postsynaptic potential, regulation of synaptic plasticity, response to environmental enrichment), suggesting a theme of neuronal connectivity and plasticity. Some terms (neutrophil clearance, myoblast differentiation, ECM disassembly, PDGF response, diadenosine tetraphosphate biosynthesis) are more peripheral or reflect broader signaling contexts, but do not override the neural core. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0090648","count":3},{"id":"GO:0021695","count":3},{"id":"GO:0097350","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0090188","count":3}]},{"hash":"2214906307263559302","title":"Neural and muscle development","description":"The GO terms suggest a developmental program spanning neural and muscle tissues (e.g., cerebellar cortex development, excitatory postsynaptic potentials, sensory perception of pain, and myoblast differentiation), with a transcriptional/dna-templated regulation component. This points to proteins involved in developmental regulation rather than a single, narrow pathway, making \u201cNeural and muscle development\u201d a concise, representative label.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0046827","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0090648","count":3}]},{"hash":"1785587938661880765","title":"Neural development and synaptic regulation","description":"This cluster shows strong enrichment for neural development and synaptic signaling terms (cerebellar cortex development, excitatory postsynaptic potential, response to environmental enrichment, regulation of synaptic plasticity). Additional terms point to growth factor signaling and extracellular matrix remodeling, suggesting broader tissue remodeling during neural development and plasticity. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0090648","count":4},{"id":"GO:0021695","count":4},{"id":"GO:0097350","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0090188","count":4}]},{"hash":"555286017558358383","title":"Skin morphogenesis and ECM assembly","description":"The top GO terms cluster around skin development and morphogenesis, plus extracellular matrix organization (collagen fibril organization, integrin biosynthetic process) and cell adhesion, consistent with proteins involved in epidermal formation and matrix remodeling. Some ancillary terms (endoderm differentiation regulation, cartilage condensation) exist but the dominant theme is skin morphogenesis and ECM interactions.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":2},{"id":"GO:0045162","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0007275","count":2},{"id":"GO:1903225","count":1}]},{"hash":"892069715316535389","title":"Retroviral DNA Integration and Latency","description":"The GO terms point to retroviral-like processes: RNA-templated DNA biosynthesis (reverse transcription), DNA integration and replication, and proviral latency, along with viral entry into the host nucleus and DNA recombination. The presence of RNA interference suppression terms and symbiont-entry/apoptosis terms suggests host-pathogen interaction contexts that accompany viral infection. Together, these terms suggest a cluster centered on retroviral life cycle steps and host interactions.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:0006278","count":2},{"id":"GO:1903704","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2}]},{"hash":"359502694057586078","title":"Neural development and axon guidance","description":"The top GO terms cluster around neural morphogenesis and maturation, including optic nerve morphogenesis, branching morphogenesis of a nerve, commissural neuron axon guidance, dendritic spine development, and long-term synaptic plasticity, with supporting links to myelination and developmental signaling (Shh). While a couple of immune-related terms appear, the predominant theme is neural development and neurite/axon differentiation, making this label representative of the cluster.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021631","count":3},{"id":"GO:0001806","count":2},{"id":"GO:0045880","count":2},{"id":"GO:0031641","count":2},{"id":"GO:0050798","count":2}]},{"hash":"1206349454560302801","title":"Cilium assembly and vision-related trafficking","description":"These proteins show strong enrichment for cilium assembly and visual perception, with related terms like receptor recycling and response to UV-B, suggesting a coherent theme around ciliary formation and sensory receptor trafficking in vision-related cells. Some unrelated terms appear as noise, but the dominant signal supports a ciliary/photoreceptor function.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006547","count":4},{"id":"GO:0072356","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0050709","count":4},{"id":"GO:0007117","count":4}]},{"hash":"1260364999633542626","title":"Reproduction and Early Development","description":"The cluster\u2019s GO terms are dominated by reproductive and embryonic processes (polyspermy prevention, regulation of sperm binding to zona pellucida, maternal axis specification, embryonic morphogenesis), with some related development and cellular processes (cuticle/molt, proteolysis). While a couple of terms (RNA exon ligation, associative learning) are less related, the overall signal points to gamete interaction and early developmental roles, giving a Moderate level of confidence.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060468","count":2},{"id":"GO:0018996","count":2},{"id":"GO:0048632","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0035124","count":2}]},{"hash":"2102933831101167322","title":"Chromatin Organization and DNA Repair","description":"This cluster centers on chromatin-related processes (nucleosome assembly, heterochromatin organization, chromatin localization) and DNA repair pathways (base excision and nucleotide excision repair), suggesting proteins that stabilize chromatin structure while contributing to genome maintenance.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0098532","count":1},{"id":"GO:0006334","count":1},{"id":"GO:0016584","count":1},{"id":"GO:0071169","count":1},{"id":"GO:0080182","count":1}]},{"hash":"2023434889774894179","title":"RNA Processing and Post-transcriptional Regulation","description":"This cluster is dominated by RNA-related functions: tRNA processing, primary miRNA processing, and mRNA capping, plus a signal for post-transcriptional gene silencing. While a few developmental terms appear, the strongest and most recurring themes are RNA maturation and regulation of gene expression at the RNA level, suggesting these proteins function together in RNA processing pathways or RNA interference-related regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":2},{"id":"GO:0070208","count":2},{"id":"GO:0070317","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0006370","count":1}]},{"hash":"2143533347754387120","title":"Redox Homeostasis and Stress Signaling","description":"Based on GO terms emphasizing oxidant detoxification, redox balance, and stress signaling (including negative regulation of JUN kinase activity), along with lipid mediator production (linoleic acid metabolism and prostaglandin biosynthesis) and DNA repair (nucleotide-excision repair). Some proliferation-related terms appear but do not define the core theme; together they point to a cluster centered on oxidative stress response and redox-related signaling.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2000255","count":4},{"id":"GO:0098869","count":4},{"id":"GO:0045454","count":3},{"id":"GO:0043508","count":3},{"id":"GO:0070664","count":3}]},{"hash":"970174152045442522","title":"Glutamatergic synaptic signaling regulators","description":"The top GO term is positive regulation of glutamatergic synaptic transmission, suggesting the proteins in this cluster are tied to modulating glutamatergic neuronal communication. Other terms point to signaling responses (cAMP/cGMP) and general proteolysis, but the most coherent signal across the set is neural synaptic regulation, making this a plausible, but not wholly cohesive, cluster theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051968","count":2},{"id":"GO:0051591","count":1},{"id":"GO:0045476","count":1},{"id":"GO:0016540","count":1},{"id":"GO:0002003","count":1}]},{"hash":"798015980286781085","title":"Diverse membrane transporters for ions and sugars","description":"These proteins are linked by transmembrane transport of diverse substrates across the plasma membrane, including ions, sugars, and xenobiotics, plus related transport-related processes. The shared function is membrane transporters with broad substrate range.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0015751","count":4},{"id":"GO:0097080","count":4},{"id":"GO:0019852","count":4}]},{"hash":"845906974610489317","title":"Heparan/dermatan sulfate proteoglycan biosynthesis","description":"The cluster\u2019s top GO terms are dominated by proteoglycan metabolic and biosynthetic processes for heparan sulfate and dermatan sulfate, including chain elongation and some obsolete biosynthetic steps, along with development-related terms such as chondrocyte development and ureteric bud formation. This points to a shared function in extracellular matrix proteoglycan production and associated developmental roles, despite some noise terms like maltose transport.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030202","count":1},{"id":"GO:0015015","count":1},{"id":"GO:0060676","count":1},{"id":"GO:0030206","count":1},{"id":"GO:0015768","count":1}]},{"hash":"2051916151645763764","title":"Glycosylation and fucosylation","description":"This cluster\u2019s top GO terms are centered on glycan processing, including protein glycosylation, Lewis A epitope biosynthesis, and N-glycan fucosylation, suggesting a shared function in glycan modification. The presence of additional neural and immune development terms appears as annotation noise or multifunctionality, so the glycosylation signal is partial but detectable. Confidence: Low","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":1},{"id":"GO:0010493","count":1},{"id":"GO:0042355","count":1},{"id":"GO:0036071","count":1},{"id":"GO:0021799","count":1}]},{"hash":"1831536427759374975","title":"Neural development and axon guidance","description":"The proteins are linked by neural development processes, especially axon guidance in retinal and motor neurons, neuron migration, and ganglion development, suggesting a cohesive function in neural patterning. A few terms reference general cellular processes, but the dominant theme remains neural development and guidance.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0031290","count":2},{"id":"GO:0008045","count":2},{"id":"GO:0001764","count":2},{"id":"GO:0061551","count":2},{"id":"GO:0007338","count":2}]},{"hash":"996028653411049808","title":"Neural axon guidance and synapse assembly","description":"Several GO terms point to neural development and connectivity, such as axon fasciculation, retinal ganglion cell axon guidance, and positive regulation of synapse assembly, with additional terms referencing interneuron differentiation. While a few terms touch on unrelated processes (angiogenesis, hedgehog signaling, osteoblast differentiation), the dominant theme is neural pathfinding and synapse formation, supporting a label focused on neural connectivity.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097155","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0031290","count":2},{"id":"GO:0002042","count":2},{"id":"GO:0045880","count":2}]},{"hash":"1630269722699590507","title":"Unknown","description":"The terms span cell\u2013cell adhesion/junction organization, integrin signaling, organ development, neural guidance, pigmentation transport, and organelle fusion, with no clear shared function tying the cluster together, so a cohesive label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903263","count":1},{"id":"GO:0086073","count":1},{"id":"GO:0045216","count":1},{"id":"GO:0033626","count":1},{"id":"GO:0003192","count":1}]},{"hash":"1998721857688872236","title":"Gustatory Receptors (Sweet, Bitter, Umami)","description":"The top GO terms point to sensory perception of sweet, bitter, and umami tastes, which strongly suggests these proteins are involved in gustatory detection/signaling. The single ATP transport term adds a potential note about ATP-related signaling in taste cells, but the dominant signal is taste perception. With four proteins and no network connections, the cluster is best labeled as a gustatory receptor-related group rather than something broader.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050913","count":1},{"id":"GO:0050917","count":1},{"id":"GO:0050916","count":1},{"id":"GO:0015867","count":1}]},{"hash":"2133019651720795034","title":"RNA splicing and translation regulation","description":"This cluster is dominated by post-transcriptional RNA processing and control: spliceosome-mediated splicing (including alternative splicing), mRNA export, and regulation of mRNA stability, plus components related to translation initiation and miRNA-mediated silencing. The co-occurrence of splicing, export, stability, and translation-focused terms suggests a cohesive theme of RNA processing and translational regulation.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":3},{"id":"GO:0075525","count":3},{"id":"GO:0035278","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0006406","count":3}]},{"hash":"1480866480137911740","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000378","count":3},{"id":"GO:0008306","count":3},{"id":"GO:1903608","count":3},{"id":"GO:1902775","count":3},{"id":"GO:0071042","count":3}]},{"hash":"2230708785117067093","title":"Copper Ion Transport and Homeostasis","description":"The GO terms strongly point to copper ion handling, including intracellular copper homeostasis, copper import across the plasma membrane, and regulation of copper transport, with xenobiotic transmembrane transport supporting transporter roles. Some entries also touch cisplatin response, which is often linked to copper transporters, suggesting these proteins function in copper uptake/maintenance and related xenobiotic handling; a couple terms may be peripheral annotations.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006878","count":1},{"id":"GO:0006855","count":1},{"id":"GO:0098705","count":1},{"id":"GO:0072719","count":1},{"id":"GO:1902311","count":1}]},{"hash":"1345591559619785511","title":"Ribosome biogenesis and RNA modification","description":"The cluster centers on nucleolar processes: ribosome biogenesis and RNA modification, evidenced by ribosome biogenesis, rRNA and snRNA pseudouridine synthesis, and box C/D snoRNP assembly. Translation is a downstream corollary of ribosome function, reinforcing this theme. Some signaling/splicing terms are present but appear secondary to the core RNA-processing role.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0000185","count":1},{"id":"GO:0000492","count":1},{"id":"GO:0048025","count":1},{"id":"GO:0031118","count":1}]},{"hash":"1996898276971678809","title":"Mitophagy and mitochondrial fusion regulation","description":"Several top GO terms explicitly describe autophagy-related processes (mitophagy; negative regulation of autophagosome maturation) and mitochondrial dynamics (positive regulation of mitochondrial fusion), suggesting the proteins contribute to mitochondrial quality control through autophagy regulation. The presence of ribosome biogenesis terms is less coherent with this theme, though they may reflect general cellular maintenance. Overall, the strongest signal is mitochondria-autophagy regulation, justifying this label.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1901340","count":3},{"id":"GO:0002109","count":3},{"id":"GO:0010636","count":3},{"id":"GO:0000423","count":3},{"id":"GO:0017085","count":3}]},{"hash":"1321685769159525995","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000378","count":3},{"id":"GO:0008306","count":3},{"id":"GO:1903608","count":3},{"id":"GO:1902775","count":3},{"id":"GO:0071042","count":3}]},{"hash":"91066117324988441","title":"Potassium transport and excitability","description":"This cluster is dominated by GO terms tied to potassium ion movement across membranes and excitable cell activities, such as neuronal action potentials and cardiac muscle membrane repolarization, plus related processes like gastric acid secretion regulation and mechanosensitive responses. While there are additional terms about SNARE regulation, actin assembly, and stress signaling, the strongest and most frequent theme centers on potassium transport and membrane electrical excitability, with supporting roles in neurotransmission and cytoskeletal dynamics. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097623","count":3},{"id":"GO:1990573","count":3},{"id":"GO:0051225","count":2},{"id":"GO:0019228","count":2},{"id":"GO:0060453","count":2}]},{"hash":"1054994795077494492","title":"Neural and ocular development with proliferation","description":"The GO terms cluster around brain and retina development, general and epithelial cell proliferation, and pigmentation, with additional regulatory processes like GTPase activity and ubiquitin ligase activity. This suggests proteins involved in neural/eye tissue development and controlled proliferation, rather than a single enzymatic function. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0060041","count":2},{"id":"GO:0043547","count":2},{"id":"GO:2001162","count":1}]},{"hash":"872304483069970034","title":"RNA processing and translation regulation","description":"The cluster shows enrichment for post-transcriptional RNA handling and control of translation, including splicing (via spliceosome), ncRNA and miRNA-mediated gene silencing, mRNA export/stability, and components involved in translation initiation, suggesting a cohesive role in RNA processing and translational regulation.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0075525","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0006406","count":2}]},{"hash":"906897812985200510","title":"Unknown","description":"There are no edges or GO terms shared among the proteins (Edges: 0; Triangles: 0; Max Degree: 0; Top Terms: empty), so no common function can be inferred to assign a specific label.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"30933125395080277","title":"Membrane Transport and Ion Homeostasis","description":"These proteins cluster around several transmembrane transport terms (chloride, bicarbonate, and sulfate transport) and regulation of membrane potential, suggesting a membrane-transport/ion homeostasis role. Lipid biosynthesis and cell wall assembly terms further support membrane-associated functions, while other terms (methylation, transcription regulation, sporulation) may reflect broader regulatory contexts or annotation noise. Overall, the strongest link is membrane transport and ion balance.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032259","count":2},{"id":"GO:0008610","count":2},{"id":"GO:0071770","count":2},{"id":"GO:1902476","count":1},{"id":"GO:0001696","count":1}]},{"hash":"1184808351377544357","title":"Unknown","description":"The GO terms are very diverse (calcium transport, myosin II assembly, synaptic potentiation, epinephrine response, heart rate regulation, cuticle and kidney development, and karyogamy), with no clear common function or pathway tying them together. This heterogeneity makes it hard to assign a coherent, specific label to the cluster beyond Unknown.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043950","count":3},{"id":"GO:0010459","count":3},{"id":"GO:0072205","count":3},{"id":"GO:0071872","count":3},{"id":"GO:0060291","count":3}]},{"hash":"242217231820614737","title":"Muscle excitation-contraction and calcium signaling","description":"This cluster is best described by terms tied to muscle physiology and calcium signaling: skeletal muscle fiber development, excitatory postsynaptic potential, locomotion, and regulation of ryanodine-sensitive calcium-release channel activity. These collectively point to neuromuscular signaling and calcium-triggered contraction as the core function, while several other terms appear as noise or cross-annotation.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:1905213","count":3},{"id":"GO:0072462","count":3},{"id":"GO:0060316","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0048741","count":3}]},{"hash":"613792711984521617","title":"RNA processing and post-transcriptional regulation","description":"The GO terms center on splicing and spliceosome activity (including alternative splicing), mRNA export and stability, and ncRNA-mediated silencing, with translation-related components as well. This points to a coherent theme of RNA processing and post-transcriptional control of gene expression, rather than other unrelated functions.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048026","count":1},{"id":"GO:0075525","count":1},{"id":"GO:0035278","count":1},{"id":"GO:0031047","count":1},{"id":"GO:0006406","count":1}]},{"hash":"1837106962415106986","title":"Bioluminescence and photoprotection","description":"The top terms include bioluminescence and photoprotection, suggesting light-related roles for the cluster. While there are additional metabolic and stress-response terms, they do not form a tighter, more specific theme than light-associated activity, so the label centers on luminescence and protection from light.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018298","count":1},{"id":"GO:0010117","count":1},{"id":"GO:0008218","count":1},{"id":"GO:0006091","count":1},{"id":"GO:0042128","count":1}]},{"hash":"63093938865157113","title":"Cerebellar neuron cytoskeleton and dendritic transport","description":"The top GO terms indicate cerebellar layer structural organization (granular and Purkinje layers) and microtubule-based processes such as dendritic transport and plus-end directed microtubule sliding, along with mitotic spindle components. This points to a shared theme of cerebellar neuron cytoskeleton organization and microtubule-driven transport, even though some terms relate to cell division. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021685","count":2},{"id":"GO:0000742","count":2},{"id":"GO:0051255","count":2},{"id":"GO:0030473","count":2},{"id":"GO:0000073","count":2}]},{"hash":"154017294118284653","title":"Dopaminergic signaling and sensory perception in neurons","description":"The top GO terms cluster around neural signaling and perception, including dopaminergic synaptic transmission, visual perception/learning, and behavioral responses to cocaine, suggesting a neuronal function focused on signal transduction and sensory processing. While a few terms (e.g., heart development, macrophage chemotaxis) are peripheral or noisy, the dominant theme ties to neural communication and drug-related behavior.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0010759","count":3}]},{"hash":"1941300504719343615","title":"Negative Regulation of Transmembrane Transport","description":"The top GO terms show negative regulation of transporter activity and transmembrane transport, indicating the proteins in this cluster are linked by an inhibitory role in membrane transport processes. Despite the small size and lack of edges, the shared regulatory annotations justify a concise label focused on transport inhibition.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032410","count":1},{"id":"GO:0034763","count":1}]},{"hash":"1779302043603354419","title":"Riboflavin biosynthesis proteins","description":"These proteins are annotated with FMN, FAD, and riboflavin biosynthetic processes, pointing to involvement in riboflavin production. The other one-off terms (phosphorylation, transport, translation, rRNA maturation) are broad and likely reflect general cellular functions or annotation noise, so the dominant theme is riboflavin biosynthesis.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009398","count":1},{"id":"GO:0006747","count":1},{"id":"GO:0009231","count":1},{"id":"GO:0016310","count":1},{"id":"GO:0033864","count":1}]},{"hash":"2079246222297809793","title":"Neuronal apoptosis and hypoxic stress response","description":"The top GO terms point to neuron-specific apoptotic processes, cellular response to hypoxia, and mitochondria-initiated apoptosis (cytochrome c release), as well as extrinsic apoptotic signaling. Together these suggest a cluster centered on neuronal cell death signaling under hypoxic or stress conditions, with some development-related terms likely incidental. Confidence is moderate due to some divergent terms, but the core theme is coherent.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051402","count":2},{"id":"GO:0071456","count":2},{"id":"GO:0090200","count":2},{"id":"GO:0006919","count":1},{"id":"GO:0045136","count":1}]},{"hash":"1075842804977620869","title":"DNA integration and transposition","description":"Top GO terms center on DNA integration, DNA transposition, and proviral latency, suggesting proteins involved in inserting DNA into genomes (e.g., transposons or proviruses). While some terms reference cell cycle or host entry, the core signal is genome integration by mobile elements, so this label captures the cluster\u2019s main function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0075713","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0007059","count":1}]},{"hash":"1911130774857318474","title":"Unknown","description":"The Top Terms are highly heterogeneous (granulocyte differentiation, multiple biosynthetic and catabolic processes, neural proliferation, histone methylation regulation, etc.) with only a couple of genes supporting each term and no clear shared pathway or function tying them together. This suggests there is no coherent theme for the cluster.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030851","count":2},{"id":"GO:0097054","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0043448","count":2},{"id":"GO:0051572","count":2}]},{"hash":"134925437549057","title":"Neural development and neuron fate specification","description":"The GO terms cluster around neural development and neuron differentiation, with emphasis on brain regions and neuronal fate (dopaminergic neuron differentiation, midbrain development, forebrain/subpallium fate, ventral spinal cord interneuron fate). Some non-neural terms appear but the dominant theme is brain-related neuronal specification, justifying this label.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0021882","count":1},{"id":"GO:0071542","count":1},{"id":"GO:0030901","count":1},{"id":"GO:0060065","count":1}]},{"hash":"1809853611243206552","title":"Unknown","description":"The GO terms for this cluster span diverse functions, including visual sensory detection, immune complement activation, proteasomal ubiquitin-dependent degradation, extracellular matrix regulation, cell adhesion and morphogenesis, and differentiation. There is no single cohesive biological process or pathway that ties these terms together, so a unique, Unknown label with no confidence is appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050908","count":1},{"id":"GO:0006471","count":1},{"id":"GO:1901202","count":1},{"id":"GO:0006956","count":1},{"id":"GO:0006511","count":1}]},{"hash":"831862484876058522","title":"Fungal Growth and Protein Handling","description":"The included GO terms cluster around fungal development (beta-glucan cell wall biosynthesis, karyogamy, cell morphogenesis) and essential protein maturation/trafficking (post-translational targeting to membranes, chaperone-assisted refolding) plus Fe-S cluster assembly. Together these describe growth, morphogenesis, and basic protein processing in fungi. Some terms are nonspecific or obsolete, but the core theme is fungal cellular growth and protein maturation.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070880","count":1},{"id":"GO:1902037","count":1},{"id":"GO:0016226","count":1},{"id":"GO:0006880","count":1},{"id":"GO:0000742","count":1}]},{"hash":"458793544823087396","title":"Unknown","description":"The top GO terms span calcium transport, heart rate and synaptic processes, muscle development, cuticle formation, and even karyogamy, which are scattered across different species and biological contexts. With no edges or coherent functional cluster linking these terms, there\u2019s no clear unifying function to assign a meaningful label beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006816","count":2},{"id":"GO:0043950","count":1},{"id":"GO:0010459","count":1},{"id":"GO:0072205","count":1},{"id":"GO:0060291","count":1}]},{"hash":"1763115772448166841","title":"Adrenergic signaling and cytoskeletal remodeling","description":"The top GO terms center on epinephrine response and heart rate regulation, together with cytoskeletal and adhesion processes (myosin II filament assembly and cell-substrate adhesion). This suggests a cohesive theme where adrenergic signaling influences cytoskeletal dynamics and cell adhesion, impacting cardiac and neural signaling as well as tissue remodeling. Some terms are older or less related (kidney development, karyogamy), but the core pattern supports the label.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043950","count":3},{"id":"GO:0010459","count":3},{"id":"GO:0072205","count":3},{"id":"GO:0010811","count":3},{"id":"GO:0071872","count":3}]},{"hash":"1846691028171070880","title":"Unknown","description":"The GO terms are a heterogeneous mix spanning neural development and synaptic function (cerebellar cortex development, excitatory postsynaptic potential, regulation of synaptic plasticity) together with terms related to immune clearance, muscle regeneration, ECM remodeling, and growth factor signaling. There isn\u2019t a single, coherent biological theme that ties these functions together for this cluster, so a specific label cannot be confidently assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090648","count":2},{"id":"GO:0021695","count":2},{"id":"GO:0097350","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0090188","count":2}]},{"hash":"287915103702498065","title":"DNA replication and genome maintenance","description":"The cluster shows strong enrichment for DNA replication and maintenance processes, including DNA recombination, replication fork dynamics, strand elongation, DNA repair, telomere maintenance, and mitochondrial DNA repair, indicating a cohesive theme of genome duplication and upkeep across compartments.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006310","count":2},{"id":"GO:0071932","count":1},{"id":"GO:0090305","count":1},{"id":"GO:0044806","count":1},{"id":"GO:1903469","count":1}]},{"hash":"1386721382948950532","title":"DNA Replication and Genome Maintenance","description":"The top GO terms cluster around DNA replication and primer processing (including synthesis and removal), fork dynamics, and homologous recombination repair, with telomere maintenance, pointing to a cohesive set of proteins involved in genome duplication and stability.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006268","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0006269","count":2},{"id":"GO:0071932","count":1},{"id":"GO:0000724","count":1}]},{"hash":"2055799172705418651","title":"Neural development and synaptic signaling","description":"The top GO terms point strongly to neural development and synaptic activity (nervous system development, cerebellar cortex development, excitatory postsynaptic potential, calcium-dependent exocytosis) with involvement of Rho signaling that guides cytoskeletal changes essential for synapse formation. Broader developmental terms (heart, skeletal) appear less central, so the neural theme appears to be the representative function of this cluster.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0007266","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0007124","count":3},{"id":"GO:0045956","count":3}]},{"hash":"1259575869755665639","title":"Autophagy-Associated Lipid and Nuclear Turnover","description":"Top terms indicate a recurring theme around autophagy-related processes, including autophagosome assembly and piecemeal microautophagy of the nucleus, with lipid droplet organization suggesting lipophagy. Several terms are obsolete or unrelated, implying a noisy mix, but the autophagy-centric terms provide a coherent if imperfect signal for the cluster\u2019s function. This yields a plausible label, though confidence is moderate due to heterogeneity and small cluster size.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034389","count":1},{"id":"GO:0061060","count":1},{"id":"GO:0031134","count":1},{"id":"GO:0000045","count":1},{"id":"GO:0034727","count":1}]},{"hash":"512320861857768965","title":"DNA replication and chromatin assembly","description":"The top GO terms cluster around nuclear DNA metabolism and chromatin organization\u2014DNA replication (GO:0006260), CENP-A\u2013containing chromatin assembly (GO:0061641), and centriolar regulation (GO:1903724)\u2014with additional signals for transcription elongation and proteostasis that align with cell-cycle\u2013related regulation. While some terms touch on trafficking and autophagy, the strongest, recurring theme is DNA replication and chromatin assembly.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0030420","count":1},{"id":"GO:0016562","count":1},{"id":"GO:0061738","count":1},{"id":"GO:1903724","count":1}]},{"hash":"1298908897411305571","title":"Neuronal signaling and synaptic plasticity","description":"The top GO terms center on long-term synaptic potentiation, cAMP signaling, calcium dynamics, phosphorylation, and GTPase regulation, all core to neural signal transduction and synaptic plasticity; surrounding terms like visual perception and amphetamine response align with neural context, supporting a neuronal signaling-focused label.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043950","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0006468","count":2},{"id":"GO:0007507","count":2}]},{"hash":"2170945809266505145","title":"Developmental Signaling Regulators","description":"The GO terms emphasize broad regulatory roles across development (lung differentiation, kidney development, dendrite extension) and signaling (GTPase activity regulation, TGF-beta signaling, transcription regulation, cytokinesis). While the cluster is small and has limited connectivity, the common thread is regulation of signaling and developmental processes rather than a single pathway, justifying the label Developmental Signaling Regulators.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032465","count":2},{"id":"GO:0060487","count":2},{"id":"GO:1903861","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0006470","count":2}]},{"hash":"1382353697894565248","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003382","count":2},{"id":"GO:0044319","count":2},{"id":"GO:0003334","count":2},{"id":"GO:1905000","count":1},{"id":"GO:0016479","count":1}]},{"hash":"1912210893794804545","title":"Unknown","description":"The top GO terms are a mix of developmental processes (brain development, leaf morphogenesis, follicle cell development, organ growth) and unrelated terms (cadmium response, histone methylation regulation, ubiquitin ligase regulation, pigmentation) with no clear common function or connections, so a cohesive label is not supported.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001162","count":1},{"id":"GO:0071276","count":1},{"id":"GO:1904668","count":1},{"id":"GO:0075525","count":1},{"id":"GO:0007420","count":1}]},{"hash":"1861539353197998092","title":"Retroviral DNA Integration and Latency","description":"The GO terms point to steps in a retroviral life cycle: reverse transcription (RNA-templated DNA biosynthesis), DNA integration into the host genome, formation of a provirus and latency, viral entry/penetration into the host nucleus, and DNA replication/recombination. Additional terms about suppression of RNA interference and host cell interactions align with viral strategies to establish infection and latency. Together these indicate a retroviral DNA integration and latency theme.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006278","count":1},{"id":"GO:1903704","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0015074","count":1},{"id":"GO:0006310","count":1}]},{"hash":"456012435560129755","title":"Terpenoid and Sterol Biosynthesis","description":"The proteins are linked to several GO terms centered on isoprenoid and sterol production, including farnesyl, geranyl, and geranylgeranyl diphosphate biosynthesis, monoterpene biosynthesis, cholesterol biosynthesis, and quinone biosynthesis, suggesting a shared role in terpenoid/isoprenoid and sterol metabolism. Some terms like protein transport or heterotetramerization appear, but the dominant theme is synthesis of isoprenoid-derived compounds. The lack of observed edges does not undermine the inferred biochemical theme across these terms.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901663","count":2},{"id":"GO:0045337","count":2},{"id":"GO:0043693","count":2},{"id":"GO:0051290","count":2},{"id":"GO:0033384","count":2}]},{"hash":"1609519820658253842","title":"Unknown","description":"The top GO terms cover highly disparate processes (immune signaling, development, RNA processing, DNA repair, transcription) with no single unifying function across the three proteins; several terms are also obsolete, making it impossible to assign a coherent, representative label.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034137","count":1},{"id":"GO:0034587","count":1},{"id":"GO:0043049","count":1},{"id":"GO:0044334","count":1},{"id":"GO:0090579","count":1}]},{"hash":"1368435025269420895","title":"Polyamine catabolism and protein acetylation","description":"Based on the top GO terms, the cluster is enriched for polyamine catabolic processes (spermine, putrescine) and acetylation modifications (N-terminal acetylation/propionylation; putrescine acetylation), suggesting a functional grouping around polyamine turnover and associated protein modifications. While other terms (melatonin biosynthesis, leaf formation, angiogenesis) appear, the strongest signal points to metabolism of polyamines and related post-translational modification activities, which likely underlie this cluster's functional coherence across the three proteins.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060358","count":3},{"id":"GO:0046208","count":3},{"id":"GO:0006474","count":3},{"id":"GO:0006041","count":3},{"id":"GO:0009447","count":3}]},{"hash":"402452486405429288","title":"Diverse Metabolism and Metal Ion Transport","description":"The top GO terms span metal ion transport (copper, zinc, cadmium) and calcium homeostasis, alongside various metabolic processes (serine biosynthesis, fructosamine metabolism, stilbene catabolism) and regulatory activities (peptidyl-tyrosine dephosphorylation). This points to a broad metabolic/ion-transport theme rather than a single cohesive function for the cluster. Confidence is Low.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035335","count":2},{"id":"GO:0030389","count":2},{"id":"GO:0006874","count":2},{"id":"GO:0046272","count":2},{"id":"GO:0006825","count":2}]},{"hash":"1025005967901278019","title":"Unknown","description":"The terms span fatty acid metabolism, ectoine and verruculogen biosynthesis, and even developmental processes, showing no coherent shared function across the proteins; therefore a specific, representative label cannot be reliably assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001561","count":1},{"id":"GO:0042400","count":1},{"id":"GO:0019491","count":1},{"id":"GO:1902181","count":1},{"id":"GO:0097089","count":1}]},{"hash":"2289438510142895268","title":"Spinal interneuron development and synapse formation","description":"This cluster centers on synapse assembly and neurotransmitter secretion, with terms about ventral spinal cord interneuron differentiation and fate commitment, suggesting a cohesive theme of spinal interneuron development and synaptic connectivity; a few apoptosis/aging terms appear incidental.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007416","count":2},{"id":"GO:0007269","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0043065","count":2},{"id":"GO:0034351","count":2}]},{"hash":"1808218398999000163","title":"Steroid and sphingolipid biosynthesis","description":"This trio is enriched for GO terms tied to biosynthesis of steroids (estrogen, testosterone) and sphingolipids (3-keto-sphinganine, sphingolipid biosynthesis), indicating a cohesive role in lipid/steroid production. Some unrelated terms exist (lung development, antibiotic response), but the dominant signal is steroid and sphingolipid biosynthesis.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006703","count":1},{"id":"GO:0006666","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0061370","count":1},{"id":"GO:0006706","count":1}]},{"hash":"1899620522155705449","title":"Unknown","description":"The top GO terms are highly diverse and chain together lipid biosynthesis, various proliferation and signaling processes, stress responses, and general cellular activities, with no single cohesive function tying the proteins together. This prevents a specific, representative label beyond Unknown.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":3},{"id":"GO:2000255","count":2},{"id":"GO:0032930","count":2},{"id":"GO:0060316","count":2},{"id":"GO:0045669","count":2}]},{"hash":"842622364992813131","title":"Multi-tissue morphogenesis and differentiation","description":"The dominant GO terms point to morphogenesis and differentiation across multiple tissues (hair follicle, aorta/vasculature, otic placode/vestibular system, retinal cells, dopaminergic neurons) with related proliferation and cytoskeletal regulation\u2014consistent with developmental remodeling rather than a single pathway. This supports a label of broad tissue development and morphogenesis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031069","count":1},{"id":"GO:0071542","count":1},{"id":"GO:0051145","count":1},{"id":"GO:0035909","count":1},{"id":"GO:2001240","count":1}]},{"hash":"673643524759946821","title":"Arabinogalactan Protein Glycosylation","description":"The GO terms are dominated by glycosylation and carbohydrate biosynthesis, especially arabinogalactan protein (AGP) metabolism and hydroxyproline-linked O-glycosylation. Several terms point to plant cell wall glycoproteins (AGPs, mucilage, polysaccharide biosynthesis) and related glycan epitopes (Lewis a, poly-N-acetyllactosamine), with additional development and adhesion roles that can be tied to AGP function. This suggests a coherent theme of AGP-type glycosylation and glycan biosynthesis across extracellular matrices and cell surfaces, rather than disparate processes.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018258","count":1},{"id":"GO:0042248","count":1},{"id":"GO:0048354","count":1},{"id":"GO:0010493","count":1},{"id":"GO:0010405","count":1}]},{"hash":"1730979952025802673","title":"Adaptive Immune Signaling and IgE Class Switching","description":"This cluster is dominated by adaptive immune processes: B cell receptor signaling, T cell receptor signaling, and positive regulation of IgE isotype switching, with supporting terms for neutrophil degranulation and beta selection. A couple of terms (uterus development, cerebellar cortex formation) appear peripheral or noisy, but the core signal clearly points to adaptive immune receptor signaling and antibody class switching.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":2},{"id":"GO:0001558","count":1},{"id":"GO:0008625","count":1},{"id":"GO:0043313","count":1},{"id":"GO:0060065","count":1}]},{"hash":"124418587533362641","title":"Riboflavin Biosynthesis","description":"The GO terms show clear enrichment for FMN, FAD, and riboflavin biosynthetic processes, pointing to vitamin B2 synthesis as the shared function of these proteins. Other single-term annotations appear incidental and do not define a common theme. Given the small cluster size and the strongest recurring signal around riboflavin biosynthesis, this label is plausible but not definitive.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009398","count":1},{"id":"GO:0006747","count":1},{"id":"GO:0009231","count":1},{"id":"GO:0016310","count":1},{"id":"GO:0033864","count":1}]},{"hash":"1043606249263712576","title":"Unknown","description":"There are no shared GO terms or interactions among the three proteins, so there is no clear functional theme to name the cluster. The lack of edges and terms prevents a confident labeling.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"112100035672732860","title":"Neuronal development and axon guidance","description":"The dominant GO terms describe neural development and connectivity, including sympathetic ganglion development, commissural neuron axon guidance, vestibulocochlear nerve organization, cell adhesion, and regulation of synaptic vesicle endocytosis, pointing to a cohesive neural development/axon guidance theme. A few terms are unrelated, but the overall signal is neural development and connectivity.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0061549","count":3},{"id":"GO:0071679","count":3},{"id":"GO:0010758","count":3},{"id":"GO:0061302","count":3},{"id":"GO:1902168","count":3}]},{"hash":"1972996055892533713","title":"Unknown","description":"The GO terms are inconsistent, listing nervous-system development and axon guidance alongside adhesion and various non-animal or unrelated processes (e.g., pollen recognition, response to catechin), with no clear common function tying the proteins. Without a coherent theme, a meaningful label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061549","count":1},{"id":"GO:0071679","count":1},{"id":"GO:0010758","count":1},{"id":"GO:0061302","count":1},{"id":"GO:1902168","count":1}]},{"hash":"2075566606868301709","title":"Neuro-immune development and apoptosis","description":"The GO terms include nervous system/brain development and immune signaling pathways (T cell receptor signaling, TLR4 signaling, B cell differentiation, T cell migration) along with apoptotic and pyroptotic processes, suggesting a cluster that links neural development with immune activity and programmed cell death.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0035234","count":1},{"id":"GO:1902109","count":1},{"id":"GO:0050852","count":1},{"id":"GO:0045577","count":1}]},{"hash":"1702055130128604740","title":"Synaptic transmission and plasticity","description":"This cluster centers on neuronal synapse functions: learning, regulation of synaptic vesicle endocytosis, inhibitory postsynaptic potentials, and acetylcholine metabolism in the synaptic cleft, alongside cytoskeletal organization at the active zone and trans-synaptic signaling, suggesting a coherent theme of synaptic transmission and plasticity. A few terms (e.g., xenobiotic response, lipid catabolism) are more general or metabolic and may be peripheral to the core synaptic theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0048789","count":1},{"id":"GO:0019441","count":1},{"id":"GO:0098942","count":1},{"id":"GO:0007612","count":1}]},{"hash":"636084844844933004","title":"Neuropeptide signaling and cardiovascular/hormonal regulation","description":"Based on the GO terms, the cluster centers on neuropeptide signaling with downstream effects on vascular function and endocrine control, including vasopressin-regulated blood pressure, renin secretion, and smooth muscle relaxation. Dopamine uptake regulation and related hormonal processes reinforce a neuroendocrine theme, while inflammatory cytokine regulation appears less prominent. Thus the tie is neuropeptide signaling linked to cardiovascular and hormonal regulation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032720","count":2},{"id":"GO:0043950","count":1},{"id":"GO:0032651","count":1},{"id":"GO:0007218","count":1},{"id":"GO:2000724","count":1}]},{"hash":"881480340302550498","title":"Mitochondrial lipid remodeling and energy metabolism","description":"The top GO terms cluster around lipid biosynthesis and remodeling (ether lipid biosynthesis, phosphatidylcholine acyl-chain and cardiolipin remodeling, CDP-diacylglycerol biosynthesis) and mitochondrial ATP synthesis, suggesting a core theme of mitochondrial membrane lipid dynamics linked to energy production. Some immune-related terms appear but are less central to the primary lipid/mitochondrial signal.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008611","count":2},{"id":"GO:0036151","count":2},{"id":"GO:0016024","count":2},{"id":"GO:0010143","count":2},{"id":"GO:0070236","count":2}]},{"hash":"732039498217850222","title":"Triglyceride catabolism and phospholipid remodeling","description":"Based on the GO terms, the cluster is dominated by lipid metabolism activities\u2014especially triglyceride mobilization and catabolic processes, triglyceride acyl-chain remodeling, and phospholipid (phosphatidylcholine and phosphatidylethanolamine) catabolic processes\u2014indicating a cohesive lipid breakdown/remodeling module. A few unrelated terms (response to cocaine, ovulation rhythm, inhibitory postsynaptic potential) appear as incidental annotations and do not define the main theme.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006642","count":2},{"id":"GO:0036153","count":2},{"id":"GO:0034638","count":2},{"id":"GO:0019433","count":2},{"id":"GO:0010898","count":2}]},{"hash":"991574557631978577","title":"Retroviral reverse transcription and proviral integration","description":"The top GO terms point to RNA-templated DNA synthesis, DNA replication, DNA integration, and proviral latency, together with viral entry into the host nucleus. This pattern aligns with retroviral infection processes: reverse transcription of viral RNA into DNA, integration into the host genome, and latency establishment, with related DNA repair/recombination and host signaling aspects observed.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0006278","count":2},{"id":"GO:1903704","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2}]},{"hash":"405923720740867382","title":"TLR signaling and interferon production","description":"Based on the top GO terms, the proteins are involved in innate immune sensing and response. The presence of multiple Toll-like receptor signaling terms (TLR2, TLR4, TLR8 pathways) and positive regulation of type II and type III interferon production, plus a defense response to Gram-positive bacteria, points to an innate immune signaling cluster focused on detecting pathogens and mounting interferon responses. A couple of terms (e.g., male gonad development) seem unrelated and likely annotation noise, but the prevalent theme remains TLR-driven immune signaling.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0034137","count":1},{"id":"GO:0032754","count":1}]},{"hash":"1340269739535522399","title":"Gut cell autophagy and programmed cell death","description":"The top GO terms cluster around autophagy-related processes (autophagosome assembly, autophagy of mitochondrion, glycophagy, microautophagy of the nucleus) and apoptotic signaling (extrinsic death receptor\u2013mediated apoptosis, larval midgut cell death), with supporting stress signals such as amino acid starvation. This combination suggests a functional theme of autophagy intersecting with cell death in gut cells.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035096","count":1},{"id":"GO:0008625","count":1},{"id":"GO:0034198","count":1},{"id":"GO:0000045","count":1},{"id":"GO:0034727","count":1}]},{"hash":"1645850973262396447","title":"Neuropeptide signaling and cardiovascular regulation","description":"This cluster is dominated by neuropeptide signaling and endocrine/cardiovascular regulation terms: neuropeptide signaling pathway, regulation of systemic arterial blood pressure by vasopressin, positive regulation of renin secretion, and dopamine uptake in synaptic transmission. While locomotory behavior is listed, the strongest cohesive signal is neuropeptide-mediated signaling influencing vascular tone and endocrine control of blood pressure and related pathways.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007626","count":3},{"id":"GO:0043950","count":2},{"id":"GO:0032651","count":2},{"id":"GO:0007218","count":2},{"id":"GO:2000724","count":2}]},{"hash":"1782503018943142693","title":"Proviral Integration and Latency","description":"The top GO terms emphasize DNA integration, replication, and recombination, plus RNA-templated DNA biosynthesis, alongside processes like proviral latency and viral entry into host cells; together these point to functions in viral genome integration and latent infection, as well as host-cell invasion.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006278","count":1},{"id":"GO:1903704","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0015074","count":1},{"id":"GO:0006310","count":1}]},{"hash":"1236891648790594202","title":"Unknown","description":"The GO terms are highly heterogeneous with few clear, overlapping functional themes (redox-related deglutathionylation and protein repair hint at maintenance, but are mixed with transcription, metal transport, and viral process terms), making a coherent cluster label untenable. Confidence: None","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0080058","count":3},{"id":"GO:1903206","count":3},{"id":"GO:0017004","count":3},{"id":"GO:0046826","count":3},{"id":"GO:0006351","count":3}]},{"hash":"1159751732772767344","title":"DNA Replication Machinery","description":"The dominant GO terms point to DNA replication processes and pre-replicative complex assembly, with terms for replication initiation, elongation, and associated nuclear cell cycle steps. A few outlier terms (photosynthesis, gas vesicle organization, chromatin-related processes) likely reflect annotation noise or multifunctional proteins, but the core signal is replication machinery.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0030466","count":1},{"id":"GO:0015979","count":1},{"id":"GO:0006267","count":1},{"id":"GO:0031412","count":1}]},{"hash":"844251744976826662","title":"Developmental Gene Regulation","description":"The top GO terms hint at regulation of gene expression and chromatin/RNA modification (RNA guanine-N7 methylation; histone methylation regulation; imprinting regulation), coupled with broad developmental processes (brain and multicellular organism development) and growth-related proliferation. While a few terms touch on stress response or pigmentation, the dominant signal is regulatory activities that influence development, suggesting the proteins participate in developmental gene regulation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036265","count":2},{"id":"GO:2001162","count":1},{"id":"GO:0071276","count":1},{"id":"GO:1904668","count":1},{"id":"GO:0007420","count":1}]},{"hash":"1172284961666634487","title":"Cytoskeleton organization and cell polarity","description":"The top GO terms cluster around spindle assembly and actin filament bundle assembly, with several terms pointing to cell growth regulation, epithelial polarity, and cell movement/migration. This suggests the proteins are connected through cytoskeletal dynamics and polarity establishment, potentially linking mitotic/spindle functions with polarized cell behavior. Although only three proteins show no interactions in this cluster, the recurring theme is cytoskeletal organization and cell polarity.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":2},{"id":"GO:0001558","count":2},{"id":"GO:0035994","count":1},{"id":"GO:0035544","count":1},{"id":"GO:0051017","count":1}]},{"hash":"1017116932145108439","title":"Immune clearance and ECM remodeling","description":"The top GO terms point to immune-cell engagement (receptor-mediated endocytosis, immunological synapse formation, apoptotic cell clearance) together with extracellular matrix organization (fibronectin and collagen fibril organization) and processes like endothelial migration. This suggests a cohesive theme around immune-vascular interactions and ECM remodeling rather than a single isolated function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006898","count":3},{"id":"GO:1905590","count":3},{"id":"GO:0001771","count":3},{"id":"GO:0043277","count":3},{"id":"GO:0016540","count":3}]}]