{"hash":"400040522070339460","title":"ER Stress\u2013Linked Translation Regulation","description":"The top GO terms cluster around translation and ER-associated protein handling: translation initiation regulation in response to ER stress, translational frameshifting, post-translational targeting to membranes, and misfolded protein transport. Redox homeostasis and negative regulation of protein kinase activity further suggest a stress-response context affecting protein synthesis and folding. A couple of terms (DNA replication, Hedgehog pathway regulation) are less connected, but the core theme points to ER-related translation regulation and quality control.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"members":[{"accession":"XP_030901774.1","go_terms":["GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]},{"accession":"XP_005145711.1","go_terms":["GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]},{"accession":"XP_005143892.1","go_terms":[]},{"accession":"XP_030900866.1","go_terms":[]},{"accession":"XP_033917127.1","go_terms":["GO:0007283"]},{"accession":"XP_033929487.1","go_terms":["GO:0032515","GO:0032516","GO:0007094"]}],"graph":[["XP_005145711.1","XP_030901774.1",0.618],["XP_033917127.1","XP_030901774.1",0.843],["XP_030900866.1","XP_030901774.1",0.726],["XP_005143892.1","XP_030901774.1",0.876],["XP_033929487.1","XP_030901774.1",0.663]],"all_go_terms":{"GO:0031204":2,"GO:0045454":2,"GO:0006452":2,"GO:0036494":2,"GO:0032781":2,"GO:0006260":2,"GO:1901621":2,"GO:0070843":2,"GO:0006469":2,"GO:0071374":2,"GO:0090084":2,"GO:0051259":2,"GO:0070389":2,"GO:0035719":2,"GO:0001707":2,"GO:1900035":2,"GO:0034975":2,"GO:0009408":2,"GO:0071630":2,"GO:0006986":2,"GO:0046825":2,"GO:0006626":2,"GO:0030433":2,"GO:0006458":2,"GO:0097428":2,"GO:0007283":1,"GO:0007094":1,"GO:0032515":1,"GO:0032516":1},"recipe_readded":[]}