{"hash":"2151508399785384540","title":"Negative Regulation of Signaling and Protein Turnover","description":"The top GO terms cluster around inhibition of signaling pathways (NF-kappaB, TNF, HIF-1alpha) and processes governing protein modification and degradation (neddylation, ubiquitin transferase activity, proteolysis), plus membrane trafficking (plasma membrane to endosome transport). This suggests a theme of regulators that dampen signaling and control protein turnover at or near the membrane.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"XP_019804346.1","go_terms":["GO:2000436","GO:0045116","GO:0051443","GO:0010332","GO:2000435","GO:0010225","GO:0044254"]},{"accession":"XP_033721307.1","go_terms":["GO:0000147","GO:0034314","GO:0030041"]},{"accession":"XP_073658526.1","go_terms":["GO:1902306","GO:0033209","GO:0032088","GO:0048227","GO:1902072","GO:2000009"]},{"accession":"XP_019796424.1","go_terms":["GO:1902306","GO:0033209","GO:0032088","GO:0048227","GO:1902072","GO:2000009"]},{"accession":"XP_033693345.1","go_terms":["GO:0000727","GO:0032508","GO:0006270","GO:0006277","GO:0072428","GO:0031938","GO:0006267","GO:0006260","GO:1900087","GO:1902977","GO:0007049"]}],"graph":[],"all_go_terms":{"GO:2000435":1,"GO:0045116":1,"GO:0051443":1,"GO:0044254":1,"GO:0010225":1,"GO:0010332":1,"GO:2000436":1,"GO:0034314":1,"GO:0030041":1,"GO:0000147":1,"GO:2000009":2,"GO:1902306":2,"GO:0032088":2,"GO:0048227":2,"GO:1902072":2,"GO:0033209":2,"GO:0000727":1,"GO:1902977":1,"GO:0006260":1,"GO:0007049":1,"GO:0072428":1,"GO:0006267":1,"GO:1900087":1,"GO:0006270":1,"GO:0032508":1,"GO:0031938":1,"GO:0006277":1},"recipe_readded":["XP_019780876.1","XP_004321251.1","XP_019796404.2","XP_019789678.1","XP_019775943.1","XP_073644314.1","XP_019785610.2","XP_033712465.1","XP_073647029.1","XP_033711482.1","XP_073652436.1","XP_019806683.1","XP_019775193.3","XP_019783362.1","XP_073660926.1","XP_033711931.1","XP_019785684.1","XP_073655072.1","XP_073644353.1","XP_033715642.1"]}