{"hash":"1043648676608602547","title":"Transcriptional regulation and genome stability","description":"The GO terms cluster around regulation of gene expression and chromatin-related processes (positive regulation of miRNA transcription, negative regulation of siRNA processing, and regulation of histone demethylase activity), together with telomere maintenance and replicative senescence, which point to genome integrity and aging. While there are hints of broader signaling contexts (Wnt signaling, hypoxia), the core theme is transcriptional control paired with genome stability and aging-related mechanisms.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"XP_033708630.1","go_terms":["GO:0030422","GO:0030177","GO:0043249","GO:0046326","GO:1902895","GO:0032092","GO:0010449","GO:0042635","GO:2000648","GO:1904173","GO:0007004","GO:0022616","GO:0070200","GO:0071456","GO:0007571","GO:1903620","GO:0060729","GO:1903704","GO:0010073","GO:0090399","GO:2001240","GO:1904751","GO:1904754","GO:0051000","GO:2000773"]},{"accession":"XP_033723821.1","go_terms":["GO:0090503","GO:0000288","GO:0033962","GO:0035195","GO:0061014","GO:0000290","GO:0045944","GO:0043928","GO:0000289"]},{"accession":"XP_019778421.1","go_terms":["GO:0015937","GO:0034628","GO:0009611","GO:0097171","GO:0019350","GO:0046444","GO:0006747","GO:1990966"]}],"graph":[],"all_go_terms":{"GO:0032092":1,"GO:0030177":1,"GO:0060729":1,"GO:1903704":1,"GO:1904173":1,"GO:2001240":1,"GO:0071456":1,"GO:1902895":1,"GO:0007004":1,"GO:0090399":1,"GO:2000773":1,"GO:0070200":1,"GO:0010073":1,"GO:0022616":1,"GO:1903620":1,"GO:1904754":1,"GO:1904751":1,"GO:0042635":1,"GO:0030422":1,"GO:0043249":1,"GO:0010449":1,"GO:0046326":1,"GO:0007571":1,"GO:2000648":1,"GO:0051000":1,"GO:0045944":1,"GO:0000289":1,"GO:0090503":1,"GO:0000290":1,"GO:0043928":1,"GO:0061014":1,"GO:0035195":1,"GO:0000288":1,"GO:0033962":1,"GO:0034628":1,"GO:0097171":1,"GO:0006747":1,"GO:0009611":1,"GO:0015937":1,"GO:0046444":1,"GO:1990966":1,"GO:0019350":1},"recipe_readded":["XP_033713377.1","XP_073662656.1","XP_019778238.1","XP_004311121.1","XP_033705446.1","XP_004311753.1","XP_033723352.1","XP_019790763.1","XP_073663574.1","XP_019775613.1","XP_033705245.1","XP_073643758.1","XP_073658281.1","XP_033695538.1","XP_033721270.1","XP_019787747.1","XP_019792320.2","XP_019777004.1","XP_033695541.1","XP_004329337.2"]}