{"hash":"1961633787869121595","title":"P53-Mediated Translation and Ribosome Biogenesis","description":"The cluster is enriched for translation and ribosome biogenesis terms (translation, cytosolic ribosome assembly, ribosomal large subunit biogenesis, regulation of translation) and also includes p53-mediated DNA damage response terms with responses to UV and gamma radiation, suggesting a link between DNA damage signaling and control of protein synthesis. This supports a functional module where the translation machinery and ribosome production are regulated in the context of p53-driven DNA damage response. ","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"members":[{"accession":"XP_038430785.1","go_terms":["GO:0070126","GO:0006412"]},{"accession":"NP_001376157.1","go_terms":["GO:0042273","GO:0071480","GO:1902167","GO:0042256","GO:0006977","GO:0034644","GO:0045727","GO:1902164","GO:0006412","GO:1904803","GO:0032784","GO:0031564","GO:0006354","GO:0006353"]},{"accession":"XP_038384889.1","go_terms":["GO:0006450","GO:0034337","GO:0000462","GO:0033120","GO:0046677","GO:0000372","GO:0006412"]},{"accession":"XP_038390672.1","go_terms":["GO:0042273","GO:0071480","GO:1902167","GO:0042256","GO:0006977","GO:0034644","GO:0045727","GO:1902164","GO:0006412","GO:1904803"]},{"accession":"XP_038390861.1","go_terms":["GO:0042255","GO:0046677","GO:0000448","GO:0006412"]},{"accession":"XP_038394901.1","go_terms":["GO:0006412"]},{"accession":"XP_038403575.1","go_terms":["GO:0090070","GO:1902626","GO:0006412"]},{"accession":"XP_038406972.1","go_terms":["GO:0042273","GO:0000463","GO:0000465","GO:0006412"]},{"accession":"XP_038410053.1","go_terms":["GO:0002181","GO:1990090","GO:0032543"]},{"accession":"XP_038411349.1","go_terms":["GO:1901194","GO:0006412"]},{"accession":"XP_038418435.1","go_terms":["GO:0015968","GO:0006415","GO:0006412","GO:0000027"]},{"accession":"XP_038425241.1","go_terms":["GO:0006415","GO:0032543","GO:0000027"]},{"accession":"XP_038422849.1","go_terms":["GO:0006412"]}],"graph":[["XP_038384889.1","NP_001376157.1",0.694],["XP_038384889.1","XP_038390672.1",0.725],["XP_038384889.1","XP_038390861.1",0.87],["XP_038384889.1","XP_038394901.1",0.752],["XP_038384889.1","XP_038403575.1",0.771],["XP_038384889.1","XP_038406972.1",0.896],["XP_038384889.1","XP_038410053.1",0.602],["XP_038384889.1","XP_038411349.1",0.553],["XP_038384889.1","XP_038418435.1",0.863],["XP_038384889.1","XP_038422849.1",0.817],["XP_038384889.1","XP_038425241.1",0.888],["XP_038384889.1","XP_038430785.1",0.944],["XP_038390672.1","NP_001376157.1",0.748],["XP_038390672.1","XP_038390861.1",0.932],["XP_038390672.1","XP_038410053.1",0.895],["XP_038390672.1","XP_038406972.1",0.907],["XP_038390672.1","XP_038403575.1",0.91],["XP_038390672.1","XP_038394901.1",0.871],["XP_038390672.1","XP_038425241.1",0.909],["XP_038390672.1","XP_038422849.1",0.947],["XP_038390672.1","XP_038418435.1",0.942],["XP_038390672.1","XP_038411349.1",0.781],["XP_038390672.1","XP_038430785.1",0.974],["XP_038410053.1","XP_038411349.1",0.657],["XP_038410053.1","XP_038418435.1",0.855],["XP_038410053.1","XP_038422849.1",0.88],["XP_038410053.1","XP_038425241.1",0.919],["XP_038410053.1","XP_038430785.1",0.954],["XP_038410053.1","NP_001376157.1",0.793],["XP_038410053.1","XP_038390861.1",0.915],["XP_038410053.1","XP_038394901.1",0.792],["XP_038410053.1","XP_038403575.1",0.795],["XP_038410053.1","XP_038406972.1",0.936],["XP_038430785.1","XP_038394901.1",0.976],["XP_038430785.1","XP_038403575.1",0.924],["XP_038430785.1","XP_038406972.1",0.963],["XP_038430785.1","XP_038411349.1",0.962],["XP_038430785.1","XP_038418435.1",0.972],["XP_038430785.1","XP_038422849.1",0.963],["XP_038430785.1","XP_038425241.1",0.968],["XP_038430785.1","NP_001376157.1",0.976],["XP_038430785.1","XP_038390861.1",0.977],["XP_038418435.1","XP_038403575.1",0.925],["XP_038418435.1","XP_038406972.1",0.937],["XP_038418435.1","XP_038411349.1",0.885],["XP_038418435.1","XP_038422849.1",0.965],["XP_038418435.1","XP_038425241.1",0.957],["XP_038418435.1","NP_001376157.1",0.906],["XP_038418435.1","XP_038390861.1",0.959],["XP_038418435.1","XP_038394901.1",0.91],["XP_038422849.1","XP_038403575.1",0.95],["XP_038422849.1","XP_038406972.1",0.933],["XP_038422849.1","XP_038411349.1",0.926],["XP_038422849.1","XP_038425241.1",0.977],["XP_038422849.1","NP_001376157.1",0.935],["XP_038422849.1","XP_038390861.1",0.963],["XP_038422849.1","XP_038394901.1",0.919],["XP_038411349.1","XP_038403575.1",0.832],["XP_038411349.1","XP_038406972.1",0.877],["XP_038411349.1","XP_038425241.1",0.898],["XP_038411349.1","NP_001376157.1",0.663],["XP_038411349.1","XP_038390861.1",0.9],["XP_038411349.1","XP_038394901.1",0.765],["NP_001376157.1","XP_038390861.1",0.914],["NP_001376157.1","XP_038406972.1",0.919],["NP_001376157.1","XP_038403575.1",0.875],["NP_001376157.1","XP_038394901.1",0.79],["NP_001376157.1","XP_038425241.1",0.892],["XP_038394901.1","XP_038390861.1",0.918],["XP_038394901.1","XP_038406972.1",0.902],["XP_038394901.1","XP_038403575.1",0.878],["XP_038394901.1","XP_038425241.1",0.927],["XP_038403575.1","XP_038425241.1",0.896],["XP_038403575.1","XP_038390861.1",0.926],["XP_038403575.1","XP_038406972.1",0.918],["XP_038425241.1","XP_038406972.1",0.962],["XP_038425241.1","XP_038390861.1",0.96],["XP_038406972.1","XP_038390861.1",0.957]],"all_go_terms":{"GO:0006412":11,"GO:0070126":1,"GO:1902167":2,"GO:0006977":2,"GO:0042256":2,"GO:0031564":1,"GO:0071480":2,"GO:0032784":1,"GO:0042273":3,"GO:0045727":2,"GO:0034644":2,"GO:0006354":1,"GO:1902164":2,"GO:1904803":2,"GO:0006353":1,"GO:0033120":1,"GO:0006450":1,"GO:0046677":2,"GO:0000372":1,"GO:0000462":1,"GO:0034337":1,"GO:0042255":1,"GO:0000448":1,"GO:1902626":1,"GO:0090070":1,"GO:0000465":1,"GO:0000463":1,"GO:0002181":1,"GO:0032543":2,"GO:1990090":1,"GO:1901194":1,"GO:0015968":1,"GO:0000027":2,"GO:0006415":2},"recipe_readded":[]}