{"hash":"1988878526332243173","title":"p53-driven cell cycle arrest and proteostasis","description":"The cluster combines cell cycle regulation (GO:0071157/GO:0071158) with p53-mediated signaling (GO:1901798) and proteostasis/ubiquitin-related terms (GO:0050821, GO:2000059, GO:1904667), suggesting a cohesive theme of p53-dependent control of cell cycle and protein stability under stress. Translation (GO:0006412) and cellular response to actinomycin D further support a stress-response context where growth is restrained and proteostasis is maintained. ","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"members":[{"accession":"XP_001509789.2","go_terms":["GO:0032986","GO:0071158","GO:0072717","GO:2000059","GO:0050821","GO:1904667","GO:1901798","GO:0006412","GO:0071157"]},{"accession":"XP_028920634.1","go_terms":["GO:0006412"]},{"accession":"XP_028935316.1","go_terms":["GO:0038018","GO:0016558","GO:0030433","GO:0060816","GO:0051865","GO:0042787","GO:0046621","GO:1900095","GO:0070936","GO:0006295","GO:0006294","GO:0006296","GO:0045116","GO:0010265","GO:0043162","GO:0000717","GO:0006293","GO:0000715","GO:0016567","GO:1902104","GO:0042769","GO:0016032","GO:0051759","GO:0031146","GO:0070911","GO:0070979","GO:0031145","GO:0051301"]},{"accession":"XP_028907701.1","go_terms":["GO:0042274","GO:0030490","GO:0042254","GO:0000028","GO:1900153","GO:0006412","GO:0006407"]}],"graph":[["XP_028935316.1","XP_001509789.2",0.944],["XP_028935316.1","XP_028907701.1",0.958],["XP_001509789.2","XP_028907701.1",0.592],["XP_001509789.2","XP_028920634.1",0.89],["XP_028907701.1","XP_028920634.1",0.824]],"all_go_terms":{"GO:0071157":1,"GO:0071158":1,"GO:0072717":1,"GO:0006412":3,"GO:0032986":1,"GO:1904667":1,"GO:2000059":1,"GO:0050821":1,"GO:1901798":1,"GO:0046621":1,"GO:1900095":1,"GO:0016558":1,"GO:0051301":1,"GO:0051865":1,"GO:0051759":1,"GO:0045116":1,"GO:0016567":1,"GO:0010265":1,"GO:0070911":1,"GO:0070936":1,"GO:0043162":1,"GO:0060816":1,"GO:1902104":1,"GO:0006294":1,"GO:0006293":1,"GO:0030433":1,"GO:0070979":1,"GO:0042787":1,"GO:0042769":1,"GO:0006296":1,"GO:0031146":1,"GO:0000717":1,"GO:0016032":1,"GO:0006295":1,"GO:0038018":1,"GO:0031145":1,"GO:0000715":1,"GO:0000028":1,"GO:0042274":1,"GO:0042254":1,"GO:0030490":1,"GO:1900153":1,"GO:0006407":1},"recipe_readded":[]}