{"hash":"1336448119115612541","title":"Heat-Responsive Proteostasis","description":"This cluster is dominated by GO terms related to heat response and unfolded protein handling, including protein folding in the ER, response to heat, and ubiquitin-proteasome\u2013mediated quality control, all core components of cellular proteostasis under stress. While a couple terms are flagged as obsolete, the shared theme is maintaining protein homeostasis via folding, maturation, and degradation pathways, especially in response to heat stress. ","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"DNA replication","members":[{"accession":"XP_001506650.1","go_terms":["GO:0090084","GO:0006458","GO:0006986","GO:0000740","GO:0070843","GO:0042787","GO:0006260","GO:1904158","GO:0006626","GO:1905259","GO:0042026","GO:0030433","GO:0009408","GO:1900035","GO:0035719","GO:0071630","GO:0034975","GO:0010198","GO:0006452","GO:0031204","GO:0071374","GO:0001707","GO:1901621","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0045454","GO:0036494","GO:0051259","GO:0046825"]},{"accession":"XP_001507642.1","go_terms":["GO:0006924","GO:0006458","GO:0006986","GO:0000002","GO:0000740","GO:0006260","GO:0042787","GO:0006626","GO:0035719","GO:0042026","GO:0030433","GO:0009408","GO:1900035","GO:1905259","GO:0034975","GO:0010198","GO:0090084","GO:0070843","GO:1904158","GO:0071630","GO:0006452","GO:0031204","GO:0071374","GO:0001707","GO:1901621","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0045454","GO:0036494","GO:0051259","GO:0046825"]},{"accession":"XP_003430853.1","go_terms":["GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]},{"accession":"XP_016082951.2","go_terms":["GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]},{"accession":"XP_001511550.1","go_terms":["GO:0006924","GO:0006458","GO:0006986","GO:0000002","GO:0000740","GO:0006260","GO:0042787","GO:0006626","GO:0035719","GO:0042026","GO:0030433","GO:0009408","GO:1900035","GO:1905259","GO:0034975","GO:0010198","GO:0090084","GO:0070843","GO:1904158","GO:0071630","GO:0006452","GO:0031204","GO:0071374","GO:0001707","GO:1901621","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0045454","GO:0036494","GO:0051259","GO:0046825"]},{"accession":"XP_001515385.1","go_terms":["GO:0006924","GO:0006458","GO:0006986","GO:0000002","GO:0000740","GO:0006260","GO:0042787","GO:0006626","GO:0035719","GO:0042026","GO:0030433","GO:0009408","GO:1900035","GO:1905259","GO:0034975","GO:0010198","GO:0090084","GO:0070843","GO:1904158","GO:0071630","GO:0006452","GO:0031204","GO:0071374","GO:0001707","GO:1901621","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0045454","GO:0036494","GO:0051259","GO:0046825"]},{"accession":"XP_001515558.1","go_terms":["GO:0090084","GO:0006458","GO:0006986","GO:0000740","GO:0070843","GO:0042787","GO:0006260","GO:1904158","GO:0006626","GO:1905259","GO:0042026","GO:0030433","GO:0009408","GO:1900035","GO:0035719","GO:0071630","GO:0034975","GO:0010198","GO:0006452","GO:0031204","GO:0071374","GO:0001707","GO:1901621","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0045454","GO:0036494","GO:0051259","GO:0046825"]},{"accession":"XP_028917517.1","go_terms":["GO:0090084","GO:0006458","GO:0006986","GO:0000740","GO:0070843","GO:0042787","GO:0006260","GO:1904158","GO:0006626","GO:1905259","GO:0042026","GO:0030433","GO:0009408","GO:1900035","GO:0035719","GO:0071630","GO:0034975","GO:0010198","GO:0006452","GO:0031204","GO:0071374","GO:0001707","GO:1901621","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0045454","GO:0036494","GO:0051259","GO:0046825"]},{"accession":"XP_028933973.1","go_terms":["GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]}],"graph":[["XP_016082951.2","XP_001506650.1",0.909],["XP_016082951.2","XP_001507642.1",0.912],["XP_016082951.2","XP_001511550.1",0.909],["XP_016082951.2","XP_001515385.1",0.891],["XP_016082951.2","XP_001515558.1",0.927],["XP_016082951.2","XP_003430853.1",0.898],["XP_016082951.2","XP_028917517.1",0.88],["XP_016082951.2","XP_028933973.1",0.936],["XP_001506650.1","XP_001507642.1",0.904],["XP_001506650.1","XP_001511550.1",0.931],["XP_001506650.1","XP_001515385.1",0.956],["XP_001506650.1","XP_001515558.1",0.901],["XP_001506650.1","XP_003430853.1",0.877],["XP_001506650.1","XP_028917517.1",0.885],["XP_001506650.1","XP_028933973.1",0.861],["XP_001511550.1","XP_001507642.1",0.961],["XP_001511550.1","XP_003430853.1",0.933],["XP_001511550.1","XP_001515385.1",0.931],["XP_001511550.1","XP_001515558.1",0.941],["XP_001511550.1","XP_028917517.1",0.93],["XP_001511550.1","XP_028933973.1",0.846],["XP_028933973.1","XP_001507642.1",0.894],["XP_028933973.1","XP_001515385.1",0.834],["XP_028933973.1","XP_001515558.1",0.83],["XP_028933973.1","XP_003430853.1",0.901],["XP_028933973.1","XP_028917517.1",0.772],["XP_001515385.1","XP_001507642.1",0.893],["XP_001515385.1","XP_001515558.1",0.925],["XP_001515385.1","XP_003430853.1",0.918],["XP_001515385.1","XP_028917517.1",0.872],["XP_001507642.1","XP_001515558.1",0.902],["XP_001507642.1","XP_003430853.1",0.887],["XP_001507642.1","XP_028917517.1",0.888],["XP_028917517.1","XP_001515558.1",0.86],["XP_028917517.1","XP_003430853.1",0.884],["XP_003430853.1","XP_001515558.1",0.902]],"all_go_terms":{"GO:1900035":9,"GO:0006626":9,"GO:0042026":6,"GO:0006986":9,"GO:0071630":9,"GO:0000740":6,"GO:0009408":9,"GO:0035719":9,"GO:0032781":9,"GO:0097428":9,"GO:0034975":9,"GO:0051259":9,"GO:0070389":9,"GO:0090084":9,"GO:0071374":9,"GO:0006260":9,"GO:0030433":9,"GO:0006452":9,"GO:0006458":9,"GO:0042787":6,"GO:1905259":6,"GO:1904158":6,"GO:0010198":6,"GO:1901621":9,"GO:0006469":9,"GO:0070843":9,"GO:0031204":9,"GO:0036494":9,"GO:0046825":9,"GO:0045454":9,"GO:0001707":9,"GO:0006924":3,"GO:0000002":3},"recipe_readded":[]}