{"hash":"1358214367315969244","title":"GI Endocrine Secretion and Signaling Regulation","description":"Interpretation centers on regulation of secretion and signaling in endocrine and gastrointestinal contexts, as evidenced by GO terms for pancreatic juice secretion, somatostatin secretion, and suppression of gastric acid, alongside positive regulation of adenylate cyclase-activating adrenergic signaling and glycogen synthase activity. The ER unfolded protein response and xenobiotic stress terms suggest secretory cell stress, while epithelial differentiation points to broader tissue context. Taken together, the dominant theme is secretion and signaling control in endocrine/GI physiology.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"members":[{"accession":"XP_014987287.1","go_terms":["GO:0030968"]},{"accession":"XP_015001084.2","go_terms":["GO:0042325","GO:0035690"]},{"accession":"XP_028693016.1","go_terms":["GO:0030968"]},{"accession":"XP_028697871.1","go_terms":[]},{"accession":"NP_001247724.1","go_terms":["GO:2000378","GO:0031101","GO:0007612","GO:0030150","GO:0006820","GO:0007270","GO:0036444","GO:1903959","GO:0001662","GO:0030855","GO:1902017","GO:1903146"]},{"accession":"NP_001027992.1","go_terms":["GO:0032869","GO:0043308","GO:0006888","GO:0090161","GO:1903595","GO:0043001","GO:0043320","GO:0098967","GO:0016240","GO:0090316","GO:0042144","GO:0042147","GO:0006891","GO:0001921","GO:0060291","GO:0016079","GO:0043312","GO:0048280","GO:1902259","GO:0043134","GO:0070254","GO:0035493","GO:1900483"]},{"accession":"XP_028702728.1","go_terms":["GO:1900017","GO:0007030","GO:0071346","GO:0051260","GO:0072616","GO:0008582","GO:1900025","GO:0016320","GO:0007019","GO:0050702","GO:0071158","GO:0051124","GO:1900227","GO:0007029","GO:0045687","GO:1900041"]},{"accession":"XP_001082471.3","go_terms":["GO:0033617","GO:0070131"]},{"accession":"NP_001247657.1","go_terms":[]},{"accession":"XP_028693172.1","go_terms":["GO:2000467","GO:0090187","GO:1903640","GO:0090274","GO:0044027","GO:0071879"]},{"accession":"XP_014975555.1","go_terms":[]},{"accession":"XP_014989745.1","go_terms":["GO:0007218","GO:0007217"]},{"accession":"XP_014989746.1","go_terms":[]},{"accession":"XP_028695599.1","go_terms":["GO:0009607","GO:0050884","GO:0097091","GO:0044381","GO:0060349","GO:0046597","GO:0035456","GO:0035455","GO:0030282","GO:0099638"]},{"accession":"NP_001181059.1","go_terms":["GO:0042273","GO:0006413"]},{"accession":"XP_001086375.2","go_terms":["GO:2000467","GO:0090187","GO:1903640","GO:0090274","GO:0044027","GO:0071879"]},{"accession":"XP_001101769.2","go_terms":[]},{"accession":"XP_014985679.2","go_terms":["GO:0071763"]}],"graph":[["NP_001181059.1","XP_028702728.1",0.576],["XP_001082471.3","XP_014989746.1",0.506]],"all_go_terms":{"GO:0030968":2,"GO:0042325":1,"GO:0035690":1,"GO:0030855":1,"GO:0031101":1,"GO:0007270":1,"GO:0036444":1,"GO:0001662":1,"GO:0030150":1,"GO:0007612":1,"GO:1903146":1,"GO:1902017":1,"GO:2000378":1,"GO:0006820":1,"GO:1903959":1,"GO:1900483":1,"GO:1903595":1,"GO:0032869":1,"GO:1902259":1,"GO:0043320":1,"GO:0043308":1,"GO:0006888":1,"GO:0043312":1,"GO:0001921":1,"GO:0070254":1,"GO:0090161":1,"GO:0016240":1,"GO:0048280":1,"GO:0043001":1,"GO:0043134":1,"GO:0042144":1,"GO:0016079":1,"GO:0090316":1,"GO:0060291":1,"GO:0042147":1,"GO:0098967":1,"GO:0006891":1,"GO:0035493":1,"GO:0072616":1,"GO:1900041":1,"GO:0071346":1,"GO:0007030":1,"GO:0050702":1,"GO:0007029":1,"GO:0016320":1,"GO:0008582":1,"GO:0045687":1,"GO:1900017":1,"GO:1900025":1,"GO:0007019":1,"GO:0051260":1,"GO:0051124":1,"GO:1900227":1,"GO:0071158":1,"GO:0070131":1,"GO:0033617":1,"GO:0044027":2,"GO:0090187":2,"GO:0071879":2,"GO:1903640":2,"GO:2000467":2,"GO:0090274":2,"GO:0007218":1,"GO:0007217":1,"GO:0097091":1,"GO:0099638":1,"GO:0035455":1,"GO:0035456":1,"GO:0044381":1,"GO:0030282":1,"GO:0009607":1,"GO:0060349":1,"GO:0046597":1,"GO:0050884":1,"GO:0042273":1,"GO:0006413":1,"GO:0071763":1},"recipe_readded":["NP_001247694.1","NP_001181733.1","NP_001028681.1","NP_001252795.1","XP_014969561.2","XP_002798536.1","XP_014985898.2","XP_001100040.1","NP_001248713.1","XP_028689839.1","XP_028709123.1","XP_001110818.2","NP_001181693.1","NP_001253489.1","XP_014969476.1","NP_001253116.1","XP_028703580.1","XP_014983187.1","XP_001113406.2","NP_001248229.1"]}