{"hash":"1720746892554991698","title":"DNA damage response and translation regulation","description":"The cluster shows enrichment for translation-related processes (translation, positive regulation of cytoplasmic translation) alongside DNA damage and cell-cycle related terms (cell division, DNA repair, regulation of apoptotic process, negative regulation of DNA binding) and protein homeostasis (protein deubiquitination). This suggests a coordinated response that links protein synthesis capacity with genome maintenance and cell fate decisions under stress, with some stress- and hormone-related signals evident (dexamethasone stimulus, antibiotic response). The mix points to a theme of stress-induced regulation of translation and genome stability pathways.","confidence":"Medium","size":12,"edges":15,"triangles":0,"max_degree":5,"top_function":null,"members":[{"accession":"XP_026191947.1","go_terms":["GO:0071549","GO:0006281","GO:0006412"]},{"accession":"XP_022586523.1","go_terms":[]},{"accession":"XP_026193536.1","go_terms":["GO:0016579","GO:0042981","GO:0043392"]},{"accession":"XP_026191621.1","go_terms":["GO:0000747","GO:0042274","GO:0000055","GO:0042254","GO:1901001","GO:0002181","GO:1903833","GO:0051301","GO:0006400","GO:0090529","GO:0007049","GO:0006413","GO:0045901","GO:0006412","GO:0014009","GO:0001514","GO:0046677","GO:0000288","GO:2000767","GO:0006415","GO:0001732"]},{"accession":"XP_026194248.1","go_terms":["GO:0046718","GO:0051289","GO:1902600","GO:0044257","GO:0009060","GO:0071432","GO:1901143","GO:0032461","GO:0010992","GO:0008286","GO:0051291","GO:0006627","GO:0010815","GO:0042447","GO:0008340","GO:0018189","GO:0006122","GO:0016032","GO:0045861","GO:0050435","GO:0007120","GO:0090062"]},{"accession":"XP_022591577.1","go_terms":[]},{"accession":"XP_026191260.1","go_terms":[]},{"accession":"XP_026194085.1","go_terms":[]},{"accession":"XP_026191354.1","go_terms":["GO:0006403","GO:0000244","GO:0045292","GO:0000956","GO:0009845","GO:0080188","GO:2000630","GO:2000636","GO:0000492","GO:0051348","GO:0006986","GO:0000278","GO:0051301","GO:0072423","GO:1903220","GO:0000464","GO:0000354","GO:0034463","GO:0098789","GO:0006378","GO:0042868"]},{"accession":"XP_026192303.1","go_terms":["GO:0006461","GO:0009236"]},{"accession":"XP_026193848.1","go_terms":[]},{"accession":"XP_026190741.1","go_terms":["GO:0030261","GO:0048235","GO:0000294","GO:0034965"]}],"graph":[["XP_026194248.1","XP_022586523.1",0.682],["XP_026194248.1","XP_026190741.1",0.578],["XP_026194248.1","XP_026191947.1",0.761],["XP_026194248.1","XP_026193536.1",0.641],["XP_026194248.1","XP_026194085.1",0.855],["XP_026191947.1","XP_022591577.1",0.504],["XP_026191947.1","XP_026191621.1",0.542],["XP_026191260.1","XP_022586523.1",0.557],["XP_026191260.1","XP_026190741.1",0.525],["XP_026191260.1","XP_026193536.1",0.613],["XP_026191260.1","XP_026194085.1",0.721],["XP_022586523.1","XP_022591577.1",0.681],["XP_026190741.1","XP_022591577.1",0.581],["XP_026194085.1","XP_022591577.1",0.501],["XP_022591577.1","XP_026193536.1",0.553]],"all_go_terms":{"GO:0006281":1,"GO:0006412":2,"GO:0071549":1,"GO:0042981":1,"GO:0016579":1,"GO:0043392":1,"GO:0014009":1,"GO:0046677":1,"GO:2000767":1,"GO:1901001":1,"GO:0042254":1,"GO:0001732":1,"GO:0000288":1,"GO:0006415":1,"GO:0051301":2,"GO:0000747":1,"GO:0007049":1,"GO:0042274":1,"GO:0001514":1,"GO:0002181":1,"GO:0045901":1,"GO:0090529":1,"GO:1903833":1,"GO:0006413":1,"GO:0000055":1,"GO:0006400":1,"GO:0008286":1,"GO:0006122":1,"GO:0045861":1,"GO:0032461":1,"GO:0010815":1,"GO:0018189":1,"GO:0016032":1,"GO:0051289":1,"GO:0071432":1,"GO:0044257":1,"GO:0008340":1,"GO:0051291":1,"GO:0046718":1,"GO:0009060":1,"GO:1902600":1,"GO:0010992":1,"GO:0007120":1,"GO:1901143":1,"GO:0006627":1,"GO:0090062":1,"GO:0042447":1,"GO:0050435":1,"GO:2000630":1,"GO:0000354":1,"GO:0000244":1,"GO:0000956":1,"GO:0080188":1,"GO:0034463":1,"GO:0000464":1,"GO:2000636":1,"GO:0051348":1,"GO:0009845":1,"GO:0006403":1,"GO:0098789":1,"GO:0000278":1,"GO:0072423":1,"GO:0006986":1,"GO:0045292":1,"GO:0000492":1,"GO:1903220":1,"GO:0006378":1,"GO:0042868":1,"GO:0009236":1,"GO:0006461":1,"GO:0034965":1,"GO:0030261":1,"GO:0048235":1,"GO:0000294":1},"recipe_readded":["XP_022589863.2","XP_026192626.1","XP_022589551.1","XP_026190559.1","XP_026193289.1","XP_026190525.1","XP_026189999.1","XP_026190158.1"]}